323:
300:
222:
197:
581:
574:
2902:
329:
228:
9577:
42:
1625:. The FGFR3 receptor has a tyrosine kinase signaling pathway that is associated with many biological developments embryonically and in tissues. Studying the tyrosine kinase signaling pathway that FGFR3 displays has played a crucial role in the development of research of several cell activities such as cell proliferation and cellular resistance to anti-cancer medications.
1561:
mutations in FGFR3 that is often fatal during the perinatal period because the child cannot breathe. There are two types. TD type I is caused by a stop codon mutation that is located in part of the gene coding for the extracellular domain of the protein. TD type II is a result of a substitution in
1545:
caused by mutations in FGFR3 that make the resulting protein overactive. Individuals with these mutation have a head size that is larger than normal and are significantly shorter in height. Only a single copy of the mutated FGFR3 gene results in achondroplasia. It is generally caused by spontaneous
1465:
at nucleotide 1138 resulting from either a G>A or G>C. This point mutation in the FGFR3 gene causes hydrogen bonds to form between two arginine side chains leading to ligand-independent stabilization of FGFR3 dimers. Overactivity of FGFR3 inhibits chondrocyte proliferation and restricts long
68:
1449:
Simplification on the mutation 46 XX 4q16.3 (female), 46XY 4q16.3 (male). Gain of function mutations in this gene can develop dysfunctional proteins "impede cartilage growth and development and affect chondrocyte proliferation and calcification" which can lead to
2603:
Schweitzer DN, Graham JM, Lachman RS, Jabs EW, Okajima K, Przylepa KA, et al. (January 2001). "Subtle radiographic findings of achondroplasia in patients with
Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3".
1573:, a disorder characterized by craniosynostosis, is caused by protein changes on FGFR3. The specific pathogenic variant c.749C>G changes the protein p.Pro250Arg, in turn resulting in this condition. Characteristics of Muenke syndrome include
336:
235:
1374:
of FGFR-3. Since the different forms are found within different tissues the protein is responsible for multiple growth factor interactions. Gain of function mutations in FGFR3 inhibits
8854:
1530:(approximately 4%) and other gliomas and may be associated with slightly improved overall survival. The FGFR3-TACC3 fusion represents a possible therapeutic target in glioblastoma.
8874:
8864:
6643:
7019:
1508:, while some FGFR3 mutations are also associated with a better prognosis. Hence FGFR3 represents a potential therapeutic target for the treatment of bladder cancer.
4187:
2447:
8849:
3326:
7384:
1024:
158:
1005:
2942:
8619:
6694:
2092:
Oo HZ, Seiler R, Black PC, Daugaard M (October 2018). "Post-translational modifications in bladder cancer: Expanding the tumor target repertoire".
8558:
7735:
6927:
6636:
9518:
7660:
4177:
2901:
2516:"Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity"
9242:
9155:
9100:
9054:
8999:
8734:
8674:
7675:
7605:
7164:
6762:
6704:
6152:
5778:
3304:
1739:
1721:
9237:
9115:
9014:
8800:
8689:
8489:
8449:
8197:
8116:
7978:
7919:
7881:
7826:
7821:
7811:
7685:
7680:
7650:
7625:
7620:
7610:
7496:
7415:
7354:
7282:
7261:
7246:
7199:
6852:
9337:
9195:
9174:
9130:
9110:
9029:
9009:
8724:
8704:
8684:
8327:
8322:
7655:
7379:
6912:
6709:
3041:
2633:
Horton WA, Lunstrum GP (December 2002). "Fibroblast growth factor receptor 3 mutations in achondroplasia and related forms of dwarfism".
9160:
9150:
9105:
9059:
9049:
9004:
8828:
8795:
8775:
8739:
8729:
8679:
8639:
8111:
8091:
8058:
7939:
7841:
7690:
6629:
6202:
5363:
4157:
2849:
1914:"Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias"
2309:
Nissenbaum M, Chung SM, Rosenberg HK, Buck BE (August 1977). "Thanatophoric dwarfism. Two case reports and survey of the literature".
9120:
9019:
8914:
8818:
8770:
8763:
8749:
8694:
8664:
8144:
8134:
8086:
8068:
7997:
7831:
7670:
7615:
5019:
3343:
3319:
3235:
1406:
affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three
1285:
8859:
8549:
6075:
2990:
1618:
1278:
8154:
7871:
5710:
5501:
4750:
3253:
1898:
2617:
2562:"Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors"
8959:
7139:
6822:
6051:
5816:
5720:
4738:
4516:
9537:
9487:
9458:
9405:
7892:
7759:
5458:
4802:
4797:
4743:
4523:
3291:
3160:
2935:
2881:
1704:
1402:
sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their
9602:
9597:
9216:
9212:
9208:
9204:
6757:
6741:
5486:
4256:
4182:
3312:
3036:
2975:
65:
7485:
7271:
7188:
5854:
5845:
5545:
5535:
5530:
5285:
5275:
5270:
4197:
3090:
3080:
3075:
1683:
1546:
mutations in germ cells; roughly 80 percent of the time, parents with children that have this disorder are normal size.
9607:
9200:
5739:
5730:
2742:"Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity"
2810:
8889:
8008:
7568:
7179:
6352:
5521:
5250:
3070:
2800:
1659:
1422:, setting in motion a cascade of downstream signals which ultimately influence cell mitogenesis and differentiation.
1395:
322:
6837:
6781:
6772:
5424:
4486:
3179:
2928:
2258:
Karczeski B, Cutting GR (1993). Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJ, Stephens K, Amemiya A (eds.).
1429:
and plays a role in bone development and maintenance. The FGFR-3 protein plays a role in bone growth by regulating
9411:
5054:
4548:
4234:
1708:
1687:
1511:
299:
9498:
9474:
8614:
8170:
8033:
5356:
4693:
4229:
3223:
1426:
1069:
3334:
9464:
6508:
5569:
5190:
4662:
4657:
4602:
4336:
3785:
3202:
1050:
9508:
7904:
7786:
7776:
6000:
5932:
5923:
4884:
4607:
3231:
3105:
2971:
2805:
221:
196:
138:
2378:
8879:
6306:
6297:
6277:
6233:
6061:
4202:
2707:"Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors"
1634:
335:
234:
9567:
9493:
7319:
5744:
4914:
3339:
3245:
2998:
1654:
1360:
1542:
328:
227:
9401:
6609:
6596:
6583:
6570:
6557:
6544:
6531:
6493:
5349:
3780:
2874:
2295:
1469:
FGFR3 mutations are also linked with spermatocytic tumor, which occur more frequently in older men.
125:
7585:
7501:
7420:
7287:
7204:
6503:
6457:
6400:
5394:
5380:
4964:
3859:
3058:
3029:
3024:
2963:
2819:
2135:
Mata DA, Benhamida JK, Lin AL, Vanderbilt CM, Yang SR, Villafania LB, et al. (November 2020).
1594:
1419:
1242:
1238:
1230:
1200:
1196:
1182:
1178:
1174:
1170:
1155:
1151:
1143:
146:
2815:
2403:
Pal SK, Rosenberg JE, Hoffman-Censits JH, Berger R, Quinn DI, Galsky MD, et al. (July 2018).
1370:
The FGFR3 gene produces various forms of the FGFR-3 protein; the location varies depending on the
9185:
6932:
6807:
6405:
6118:
6109:
4928:
2980:
2951:
1899:"Entrez Gene: FGFR3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)"
1554:
1501:
5341:
2186:
1367:, location p16.3, is expressed in tissues such as the cartilage, brain, intestine, and kidneys.
1234:
1226:
1186:
1147:
1139:
9469:
9085:
8989:
8609:
8028:
7014:
6652:
5407:
4271:
4266:
4261:
4251:
3558:
3486:
2955:
2740:
Olsen SK, Ibrahimi OA, Raucci A, Zhang F, Eliseenkova AV, Yayon A, et al. (January 2004).
2004:"FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin"
9543:
7740:
7024:
6663:
6426:
6345:
6070:
5754:
3615:
3533:
1455:
1403:
17:
2352:
9483:
8869:
7801:
7750:
6498:
4852:
4565:
3286:
3155:
2867:
2753:
1770:
1759:"Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3"
1622:
1582:
1482:
1434:
210:
166:
1514:
of FGFR3 occur in bladder cancer that do not occur in normal cells and can be targeted by
8:
8624:
8038:
6462:
5768:
4879:
4698:
3012:
3007:
2705:
Hernández S, Toll A, Baselga E, Ribé A, Azua-Romeo J, Pujol RM, et al. (July 2007).
2448:"Novel FGFR3 Inhibitor May Be a New Treatment Option for Metastatic Urothelial Carcinoma"
2137:"Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions"
1526:
FGFR3-TACC3 fusions have been identified as the primary mitogenic drivers in a subset of
2757:
1774:
1437:
occurs and additional variants have been described, including those utilizing alternate
8302:
6655:
6395:
6142:
6133:
5961:
5952:
4286:
4020:
3002:
2658:
2586:
2561:
2429:
2404:
2334:
2283:
2163:
2136:
2117:
2069:
2044:
1938:
1913:
1845:
1820:
170:
2776:
2741:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
692:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
8929:
6186:
2920:
2835:
2826:
2781:
2728:
2693:
2650:
2621:
2591:
2537:
2493:
2434:
2326:
2265:
2168:
2109:
2074:
2025:
1984:
1943:
1850:
1798:
1793:
1758:
1602:
1515:
1462:
1383:
118:
58:
6621:
2338:
2121:
1963:"Fibroblast growth factor receptors, developmental corruption and malignant disease"
9347:
8479:
6441:
6436:
6410:
6338:
5463:
5449:
5059:
4792:
4713:
4276:
3469:
3395:
3019:
2771:
2761:
2718:
2683:
2662:
2642:
2613:
2581:
2573:
2527:
2483:
2424:
2416:
2318:
2158:
2148:
2101:
2064:
2056:
2015:
1974:
1933:
1925:
1840:
1832:
1788:
1778:
1558:
1478:
1451:
415:
346:
290:
245:
2105:
150:
6488:
6472:
6385:
5705:
5695:
5690:
5670:
5665:
5660:
5655:
5650:
5641:
5376:
5119:
3655:
3650:
3573:
2688:
2672:"[Hereditary skeletal dysplasias and FGFR3 and PTHR1 signaling pathways]"
2671:
2420:
1606:
1570:
1477:
Defects in the FGFR3 gene has been associated with several conditions, including
1415:
1371:
390:
174:
2207:
1821:"Advances in research on and diagnosis and treatment of achondroplasia in China"
1744:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1726:
National Center for
Biotechnology Information, U.S. National Library of Medicine
9581:
9533:
9454:
9396:
9090:
8939:
8934:
8048:
8043:
6689:
6679:
6674:
6526:
6467:
6181:
6176:
6171:
5555:
5372:
4904:
4326:
3837:
3640:
3192:
2746:
Proceedings of the
National Academy of Sciences of the United States of America
2322:
2153:
1763:
Proceedings of the
National Academy of Sciences of the United States of America
1574:
1538:
1505:
1407:
1379:
491:
2646:
2259:
1836:
580:
573:
9591:
9227:
9140:
9069:
9039:
8974:
8884:
8838:
8714:
8644:
8589:
8578:
8063:
7771:
7454:
7359:
7251:
6431:
6390:
5617:
5478:
4874:
4331:
3422:
3127:
3122:
3117:
2853:
2532:
2515:
1578:
609:
2766:
1979:
1962:
551:
429:
9553:
9523:
9262:
9252:
9145:
9044:
8899:
8719:
8654:
8569:
8073:
7876:
7715:
7710:
7630:
7580:
7394:
7148:
7129:
7108:
7079:
6802:
6797:
6380:
6162:
5873:
5864:
5608:
5230:
4538:
4528:
4059:
4025:
3111:
2785:
2732:
2723:
2706:
2697:
2654:
2625:
2595:
2541:
2488:
2471:
2438:
2269:
2172:
2113:
2078:
2029:
2020:
2003:
1988:
1961:
Kelleher FC, O'Sullivan H, Smyth E, McDermott R, Viterbo A (October 2013).
1947:
1854:
1783:
1598:
1590:
1527:
1430:
1364:
408:
187:
2497:
2060:
1802:
1617:
FGFR3 inhibitors are in early clinical trials as a cancer treatment, e.g.
1325:
1320:
9513:
9479:
9377:
9367:
9362:
9352:
9302:
9125:
9024:
8785:
8699:
8629:
8524:
8287:
8252:
8202:
8165:
8101:
7983:
7914:
7866:
7856:
7851:
7846:
7730:
7725:
7720:
7098:
7009:
6999:
6967:
6962:
6957:
6952:
6942:
6902:
6867:
6604:
6539:
6375:
5240:
4889:
4667:
4642:
4341:
3963:
3889:
3363:
2330:
1411:
1375:
1114:
1095:
2801:
2472:"Expression and biological activity of mouse fibroblast growth factor-9"
129:, ACH, CD333, CEK2, HSFGFR3EX, JTK4, fibroblast growth factor receptor 3
9332:
9297:
9292:
9282:
9272:
9190:
8979:
8954:
8944:
8790:
8744:
8604:
8430:
8399:
8368:
8337:
8282:
8257:
8237:
8222:
8212:
8106:
8023:
7816:
7796:
7695:
7640:
7635:
7459:
7364:
7349:
7144:
7103:
7075:
7044:
7004:
6907:
6862:
6857:
6832:
6827:
6817:
6730:
6724:
6714:
6287:
6282:
6272:
6267:
6258:
6207:
6123:
6013:
5170:
4894:
4575:
4316:
4192:
3825:
3820:
3815:
3670:
3454:
2618:
10.1002/1096-8628(20010101)98:1<75::AID-AJMG1010>3.0.CO;2-6
2045:"A place for precision medicine in bladder cancer: targeting the FGFRs"
1929:
1586:
1441:
8 rather than 9, but their full-length nature has not been determined.
1399:
307:
204:
154:
687:
95:
91:
87:
9357:
9327:
9322:
9317:
9312:
9307:
9287:
9277:
9267:
9257:
8949:
8909:
8805:
8780:
8539:
8534:
8529:
8519:
8514:
8509:
8499:
8420:
8358:
8292:
8272:
8267:
8262:
8247:
8242:
8232:
8227:
8121:
8096:
7861:
7781:
7700:
7645:
7535:
7474:
7464:
7369:
7256:
7054:
7049:
7039:
6947:
6937:
6922:
6897:
6892:
6882:
6877:
6872:
6578:
6552:
5009:
5004:
4999:
4989:
4984:
4979:
4974:
2577:
1873:
1819:
Wang Y, Liu Z, Liu Z, Zhao H, Zhou X, Cui Y, et al. (May 2013).
969:
374:
361:
273:
260:
162:
2043:
di
Martino E, Tomlinson DC, Williams SV, Knowles MA (October 2016).
1960:
9576:
9528:
9247:
8904:
8504:
8494:
8474:
8217:
8207:
7554:
7034:
6977:
6887:
6847:
6022:
5429:
5315:
5215:
5029:
5014:
4217:
4212:
4120:
3810:
2910:: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
2470:
Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM (January 1996).
2228:
1562:
a Lsy650Glu which is located in the tyrosine kinase area of FGFR3.
1498:
1309:
8409:
8378:
8347:
8311:
2469:
2042:
9503:
8924:
8389:
7791:
6752:
5371:
5265:
5260:
5255:
5155:
4969:
4959:
4786:
4765:
4760:
4728:
4533:
4453:
4448:
4443:
4438:
4433:
4351:
4044:
3884:
3879:
3874:
3869:
3864:
3335:
2840:
2830:
2402:
1911:
1345:
1081:
1036:
954:
950:
1418:
domain. The extracellular portion of the protein interacts with
940:
transmembrane receptor protein tyrosine kinase signaling pathway
142:
9416:
9080:
8969:
8894:
8599:
8594:
8018:
8013:
7967:
7963:
7959:
7955:
7951:
7947:
7943:
7595:
7134:
6812:
6591:
6361:
6311:
5999:
5574:
5510:
5505:
5205:
5165:
5150:
5134:
5129:
5109:
5104:
5039:
4847:
4817:
4781:
4772:
4585:
4553:
4417:
4412:
4382:
4361:
4321:
4281:
4147:
4125:
4084:
4008:
4003:
3998:
3993:
3988:
3983:
3852:
3847:
3842:
3790:
3775:
3645:
3635:
3598:
3593:
3511:
3506:
3263:
3258:
1293:
991:
910:
positive regulation of tyrosine phosphorylation of STAT protein
589:
41:
2859:
1757:
Keegan K, Johnson DE, Williams LT, Hayman MJ (February 1991).
9448:
9444:
9440:
9436:
9432:
9428:
9424:
9420:
9135:
9034:
8709:
8649:
8463:
8186:
8182:
8178:
8174:
7665:
7529:
7448:
7444:
7343:
7339:
7335:
7331:
7240:
7236:
7087:
6565:
6099:
5977:
5942:
5937:
5913:
5715:
5700:
5685:
5680:
5675:
5627:
5622:
5598:
5593:
5584:
5496:
5491:
5468:
5439:
5434:
5330:
5305:
5225:
5220:
5210:
5200:
5185:
5180:
5175:
5160:
5114:
5099:
5064:
5049:
5044:
5034:
4954:
4949:
4944:
4923:
4919:
4909:
4822:
4723:
4718:
4677:
4627:
4622:
4617:
4612:
4597:
4590:
4570:
4558:
4501:
4496:
4491:
4481:
4476:
4469:
4407:
4397:
4392:
4387:
4377:
4356:
4346:
4311:
4306:
4301:
4296:
4291:
4246:
4241:
4207:
4172:
4167:
4162:
4152:
4140:
4135:
4115:
4110:
4105:
4100:
4054:
3946:
3941:
3760:
3744:
3737:
3732:
3727:
3722:
3717:
3712:
3687:
3665:
3660:
3553:
3479:
3474:
3464:
3270:
3142:
3046:
2514:
Chellaiah A, Yuan W, Chellaiah M, Ornitz DM (December 1999).
1912:
Foldynova-Trantirkova S, Wilcox WR, Krejci P (January 2012).
1494:
840:
positive regulation of phosphatidylinositol 3-kinase activity
830:
fibroblast growth factor receptor apoptotic signaling pathway
2825:
Overview of all the structural information available in the
2513:
2308:
8919:
7525:
7521:
7517:
7513:
7509:
7505:
7440:
7436:
7432:
7428:
7424:
7327:
7323:
7315:
7311:
7307:
7303:
7299:
7295:
7291:
7232:
7228:
7224:
7220:
7216:
7212:
7208:
7160:
7156:
7152:
7118:
7083:
7064:
6217:
6147:
6094:
6085:
6046:
6037:
6027:
5908:
5899:
5889:
5835:
5826:
5811:
5802:
5792:
5787:
5763:
5564:
5416:
5393:
5325:
5320:
5310:
5300:
5295:
5290:
5245:
5235:
5195:
5124:
5094:
5089:
5084:
5079:
5074:
5069:
5024:
4994:
4899:
4867:
4862:
4842:
4832:
4827:
4812:
4807:
4708:
4703:
4672:
4652:
4647:
4637:
4632:
4511:
4464:
4424:
4079:
4074:
4069:
4064:
4049:
4040:
4035:
4030:
4015:
3973:
3968:
3958:
3953:
3936:
3931:
3926:
3921:
3916:
3911:
3906:
3901:
3896:
3832:
3805:
3800:
3795:
3770:
3765:
3702:
3697:
3692:
3682:
3677:
3630:
3625:
3620:
3610:
3605:
3588:
3583:
3578:
3568:
3563:
3548:
3543:
3538:
3528:
3523:
3518:
3501:
3496:
3491:
3442:
3410:
3405:
3400:
3383:
3378:
3373:
3368:
3207:
3197:
3175:
2602:
1756:
1642:
1638:
1438:
1352:
6330:
2560:
Duperret EK, Oh SJ, McNeal A, Prouty SM, Ridky TW (2014).
2134:
6248:
6243:
6238:
6212:
4837:
3449:
3437:
3432:
3427:
3417:
3390:
3358:
1905:
2739:
2704:
398:
2223:
2221:
673:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
648:
transmembrane receptor protein tyrosine kinase activity
9519:
Pituitary adenylate cyclase-activating peptide (PACAP)
2950:
2559:
1633:
Fibroblast growth factor receptor 3 has been shown to
9565:
6651:
2091:
905:
phosphatidylinositol-3-phosphate biosynthetic process
563:
2218:
1425:
This particular family member binds both acidic and
865:
positive regulation of cell population proliferation
658:
fibroblast growth factor-activated receptor activity
2191:
Genetic and Rare
Diseases Information Center (GARD)
2179:
900:
phosphatidylinositol phosphate biosynthetic process
850:
fibroblast growth factor receptor signaling pathway
9465:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
8323:Glial cell line-derived neurotrophic factor (GDNF)
7976:Cleavage products/derivatives with unknown target:
2811:GeneReviews/NIH/NCBI/UW entry on Hypochondroplasia
2001:
1700:
1698:
1696:
1679:
1677:
1675:
920:positive regulation of protein kinase B signaling
345:
244:
27:Gene involved in the most common form of dwarfism
9589:
9499:Macrophage-stimulating protein (MSP; HLP, HGFLP)
2806:GeneReviews/NIH/NCBI/UW entry on Muenke Syndrome
2669:
2257:
2253:
2251:
2249:
7140:Heparin-binding EGF-like growth factor (HB-EGF)
6823:Heparin-binding EGF-like growth factor (HB-EGF)
2509:
2507:
1693:
1672:
2635:Reviews in Endocrine & Metabolic Disorders
2632:
2465:
2463:
1818:
1705:GRCm38: Ensembl release 89: ENSMUSG00000054252
9551:Additional growth factor receptor modulators:
6637:
6346:
5357:
3320:
2936:
2875:
2839:(Fibroblast growth factor receptor 3) at the
2246:
1954:
845:positive regulation of phospholipase activity
7905:Insulin-like growth factor-2 (somatomedin A)
7787:Insulin-like growth factor-2 (somatomedin A)
7777:Insulin-like growth factor-1 (somatomedin C)
2504:
2396:
2202:
2200:
2085:
2036:
1414:membrane-spanning segment and a cytoplasmic
870:positive regulation of ERK1 and ERK2 cascade
2460:
1995:
1868:
1866:
1864:
1814:
1812:
1684:GRCh38: Ensembl release 89: ENSG00000068078
805:negative regulation of developmental growth
6644:
6630:
6353:
6339:
5364:
5350:
3327:
3313:
2943:
2929:
2882:
2868:
2850:United States National Library of Medicine
2302:
2002:Hafner C, Hartmann A, Vogt T (July 2007).
1750:
1549:
1454:and multiple types of skeletal dysplasia (
925:negative regulation of signal transduction
3344:list of human clusters of differentiation
2818:at the U.S. National Library of Medicine
2775:
2765:
2722:
2687:
2585:
2531:
2487:
2445:
2428:
2197:
2162:
2152:
2068:
2019:
1978:
1937:
1844:
1792:
1782:
693:transmembrane signaling receptor activity
9509:Migration-stimulating factor (MSF; PRG4)
2991:Receptor protein serine/threonine kinase
2848:This article incorporates text from the
2711:The Journal of Investigative Dermatology
2670:Bonaventure J, Silve C (November 2005).
2353:"Muenke syndrome (Concept Id: C1864436)"
2233:National Human Genome Research Institute
2008:The Journal of Investigative Dermatology
1861:
1825:Intractable & Rare Diseases Research
1809:
1461:In achondroplasia, the FGFR3 gene has a
935:negative regulation of apoptotic process
678:1-phosphatidylinositol-3-kinase activity
6838:Transforming growth factor alpha (TGFα)
14:
9590:
9412:Connective tissue growth factor (CTGF)
9475:Hepatoma-derived growth factor (HDGF)
6625:
6334:
5998:
5392:
5345:
3308:
2924:
2863:
2264:. University of Washington, Seattle.
739:integral component of plasma membrane
350:
311:
306:
249:
208:
203:
2606:American Journal of Medical Genetics
2214:. U.S. National Library of Medicine.
2141:Acta Neuropathologica Communications
1363:333). The gene, which is located on
1355:. FGFR3 has also been designated as
2520:The Journal of Biological Chemistry
2476:The Journal of Biological Chemistry
1880:. U.S. National Library of Medicine
1612:
1338:Fibroblast growth factor receptor 3
890:positive regulation of MAPK cascade
464:dorsal motor nucleus of vagus nerve
24:
2552:
1565:
1472:
25:
9619:
2794:
2049:Future Oncology (London, England)
1660:Fibroblast growth factor receptor
1533:
1488:
1396:fibroblast growth factor receptor
1348:that in humans is encoded by the
880:peptidyl-tyrosine phosphorylation
9575:
9494:Leukemia inhibitory factor (LIF)
2900:
1557:is a genetic disorder caused by
668:protein tyrosine kinase activity
653:fibroblast growth factor binding
579:
572:
522:lumbar subsegment of spinal cord
334:
327:
321:
298:
233:
226:
220:
195:
40:
8662:Negative allosteric modulators:
2889:
2371:
2345:
2229:"Learning about Achondroplasia"
2128:
1628:
1521:
1512:Post-translational modification
1504:are frequently associated with
8980:Gossypetin (3,5,7,8,3',4'-HHF)
8171:Platelet-derived growth factor
3254:Platelet-derived growth factor
3224:Tumor necrosis factor receptor
1891:
1732:
1714:
1427:basic fibroblast growth factor
714:integral component of membrane
590:More reference expression data
552:More reference expression data
13:
1:
9186:Placental growth factor (PGF)
6001:Non-receptor tyrosine kinases
2106:10.1016/j.urolonc.2018.09.001
1665:
319:
218:
9470:Glia maturation factor (GMF)
7979:Glypromate (GPE, (1-3)IGF-1)
3292:Insulin-like growth factor 2
3161:Insulin-like growth factor 1
2421:10.1158/2159-8290.CD-18-0229
1444:
1378:proliferation and underlies
7:
9603:Clusters of differentiation
9598:Genes on human chromosome 4
6360:
3340:clusters of differentiation
2976:Ciliary neurotrophic factor
2379:"Orphanet: Muenke syndrome"
1648:
1389:
915:skeletal system development
875:protein autophosphorylation
795:chondrocyte differentiation
10:
9624:
9402:Colony-stimulating factors
9394:Additional growth factors:
3037:Bone morphogenetic protein
2689:10.1051/medsci/20052111954
2446:James Nam (May 31, 2018).
2323:10.1177/000992287701600803
2154:10.1186/s40478-020-01058-6
1655:Cluster of differentiation
1493:Mutations of FGFR3, FGFR3–
1394:FGFR-3 is a member of the
1361:cluster of differentiation
9608:Tyrosine kinase receptors
9386:
9173:
9068:
8837:
8750:SNA-120 (pegylated K252a)
8577:
8568:
8548:
8462:
8439:
8408:
8377:
8346:
8310:
8301:
8153:
7996:
7929:
7922:(against IGF-1 and IGF-2)
7891:
7884:(against IGF-1 and IGF-2)
7758:
7749:
7567:
7544:
7484:
7403:
7270:
7187:
7178:
7117:
7063:
6976:
6780:
6771:
6740:
6662:
6517:
6509:Michaelis–Menten kinetics
6481:
6450:
6419:
6368:
6296:
6257:
6226:
6195:
6161:
6132:
6108:
6084:
6060:
6036:
6012:
6008:
5994:
5970:
5951:
5922:
5898:
5882:
5863:
5844:
5825:
5801:
5777:
5753:
5729:
5640:
5607:
5583:
5554:
5520:
5477:
5448:
5415:
5406:
5402:
5395:Receptor tyrosine kinases
5388:
5143:
4937:
4686:
4370:
4093:
3753:
3351:
3279:
3244:
3222:
3188:
3171:
3151:
3138:
3101:
3066:
3057:
2989:
2962:
2895:
1837:10.5582/irdr.2013.v2.2.45
1740:"Mouse PubMed Reference:"
1722:"Human PubMed Reference:"
1543:dominant genetic disorder
1420:fibroblast growth factors
1324:
1319:
1315:
1308:
1292:
1273:
1260:
1256:
1223:
1219:
1212:
1193:
1169:
1136:
1132:
1125:
1112:
1108:
1093:
1089:
1080:
1067:
1063:
1048:
1044:
1035:
1022:
1018:
1003:
999:
990:
975:
968:
964:
948:
860:chondrocyte proliferation
820:endochondral ossification
683:identical protein binding
608:
604:
587:
571:
562:
549:
526:medial vestibular nucleus
498:
489:
436:
427:
397:
389:
385:
368:
355:
318:
297:
288:
284:
267:
254:
217:
194:
185:
181:
136:
133:
123:
116:
111:
84:
79:
62:
57:
52:
48:
39:
34:
7586:Hepatocyte growth factor
7145:Neuregulins (heregulins)
7076:Neuregulins (heregulins)
7020:Trastuzumab duocarmazine
6733:(against angiopoietin 2)
6727:(against angiopoietin 3)
6401:Diffusion-limited enzyme
3143:Hepatocyte growth factor
3071:Fibroblast growth factor
3059:Receptor tyrosine kinase
2964:Type I cytokine receptor
2820:Medical Subject Headings
2533:10.1074/jbc.274.49.34785
1410:-like domains, a single
885:endochondral bone growth
688:receptor tyrosine kinase
514:dorsal tegmental nucleus
468:internal globus pallidus
460:external globus pallidus
6933:Depatuxizumab mafodotin
5408:Growth factor receptors
3180:Epidermal growth factor
2956:growth factor receptors
2767:10.1073/pnas.0307287101
2647:10.1023/A:1020914026829
2261:Thanatophoric Dysplasia
2212:Genetics Home Reference
1878:Genetics Home Reference
1555:Thanatophoric dysplasia
1550:Thanatophoric dysplasia
1286:Chr 5: 33.88 – 33.89 Mb
855:protein phosphorylation
633:protein kinase activity
9556:(neurotrophin mixture)
9544:Wnt signaling proteins
9225:Allosteric modulators:
8945:Norwogonin (5,7,8-THF)
7165:5 (tomoregulin, TMEFF)
7015:Trastuzumab deruxtecan
6653:Growth factor receptor
2724:10.1038/sj.jid.5700705
2489:10.1074/jbc.271.3.1726
2452:Cancer Therapy Advisor
2021:10.1038/sj.jid.5700772
1784:10.1073/pnas.88.4.1095
530:ventral tegmental area
510:deep cerebellar nuclei
9484:T-cell growth factors
7741:Telisotuzumab vedotin
7025:Trastuzumab emtansine
6494:Eadie–Hofstee diagram
6427:Allosteric regulation
2061:10.2217/fon-2016-0042
1980:10.1093/carcin/bgt254
1456:osteochondrodysplasia
1279:Chr 4: 1.79 – 1.81 Mb
759:endoplasmic reticulum
8069:EVT-901 (SAR-127963)
7802:Mecasermin rinfabate
6504:Lineweaver–Burk plot
5479:PDGF receptor family
3232:Nerve growth factors
3106:Nerve growth factors
2972:Nerve growth factors
2816:FGFR3+protein,+human
1623:urothelial carcinoma
1577:synostosis (usually
1483:seborrheic keratosis
1435:Alternative splicing
930:cell differentiation
749:extracellular region
623:transferase activity
506:skin of external ear
352:5 B2|5 17.83 cM
313:Chromosome 5 (mouse)
211:Chromosome 4 (human)
80:List of PDB id codes
53:Available structures
5883:ROS receptor family
5417:EGF receptor family
2758:2004PNAS..101..935O
2405:"FGFR3 Alterations"
2311:Clinical Pediatrics
1775:1991PNAS...88.1095K
1609:are also possible.
1595:developmental delay
1583:midfacial retrusion
810:cell-cell signaling
790:bone mineralization
764:cytoplasmic vesicle
452:gingival epithelium
9235:Kinase inhibitors:
9098:Kinase inhibitors:
8997:Kinase inhibitors:
8672:Kinase inhibitors:
8487:Kinase inhibitors:
8447:Kinase inhibitors:
8428:Kinase inhibitors:
8397:Kinase inhibitors:
8366:Kinase inhibitors:
8335:Kinase inhibitors:
8195:Kinase inhibitors:
7809:Kinase inhibitors:
7603:Kinase inhibitors:
7392:Kinase inhibitors:
7385:Aprutumab ixadotin
7032:Kinase inhibitors:
6845:Kinase inhibitors:
6702:Kinase inhibitors:
6463:Enzyme superfamily
6396:Enzyme promiscuity
2852:, which is in the
1930:10.1002/humu.21636
1599:Turribrachycephaly
1070:ENSMUSG00000054252
815:bone morphogenesis
783:Biological process
702:Cellular component
628:nucleotide binding
616:Molecular function
9563:
9562:
9169:
9168:
8930:N-Acetylserotonin
8829:ReN-1820 (TrkAd5)
8458:
8457:
7992:
7991:
7937:Binding proteins:
7596:Dihexa (PNB-0408)
7563:
7562:
7174:
7173:
7088:6 (neuroglycan C)
6808:EGF (urogastrone)
6786:
6619:
6618:
6328:
6327:
6324:
6323:
6320:
6319:
5990:
5989:
5986:
5985:
5636:
5635:
5339:
5338:
3302:
3301:
3218:
3217:
2918:
2917:
2676:Médecine/Sciences
2094:Urologic Oncology
1516:immunotherapeutic
1463:missense mutation
1384:hypochondroplasia
1335:
1334:
1331:
1330:
1304:
1303:
1269:
1268:
1250:
1249:
1208:
1207:
1163:
1162:
1121:
1120:
1102:
1101:
1076:
1075:
1057:
1056:
1031:
1030:
1012:
1011:
960:
959:
895:apoptotic process
744:transport vesicle
600:
599:
596:
595:
558:
557:
545:
544:
483:
482:
381:
380:
280:
279:
175:FGFR3 - orthologs
107:
106:
103:
102:
63:Ortholog search:
16:(Redirected from
9615:
9580:
9579:
9571:
9375:Decoy receptors:
9348:Alacizumab pegol
8826:Decoy receptors:
8575:
8574:
8480:Stem cell factor
8421:Persephin (PSPN)
8359:Neurturin (NRTN)
8308:
8307:
8145:LEVI-04 (p75-Fc)
8142:Decoy receptors:
7756:
7755:
7185:
7184:
6784:
6778:
6777:
6646:
6639:
6632:
6623:
6622:
6499:Hanes–Woolf plot
6442:Enzyme activator
6437:Enzyme inhibitor
6411:Enzyme catalysis
6355:
6348:
6341:
6332:
6331:
6010:
6009:
5996:
5995:
5450:Insulin receptor
5413:
5412:
5404:
5403:
5390:
5389:
5377:tyrosine kinases
5366:
5359:
5352:
5343:
5342:
3329:
3322:
3315:
3306:
3305:
3271:Stem cell factor
3236:Low affinity/p75
3064:
3063:
2945:
2938:
2931:
2922:
2921:
2904:
2884:
2877:
2870:
2861:
2860:
2789:
2779:
2769:
2736:
2726:
2701:
2691:
2666:
2629:
2599:
2589:
2578:10.4161/cc.28492
2546:
2545:
2535:
2526:(49): 34785–94.
2511:
2502:
2501:
2491:
2467:
2458:
2455:
2442:
2432:
2409:Cancer Discovery
2400:
2394:
2393:
2391:
2389:
2375:
2369:
2368:
2366:
2364:
2349:
2343:
2342:
2306:
2300:
2299:
2293:
2289:
2287:
2279:
2277:
2276:
2255:
2244:
2243:
2241:
2239:
2225:
2216:
2215:
2204:
2195:
2194:
2187:"Achondroplasia"
2183:
2177:
2176:
2166:
2156:
2132:
2126:
2125:
2089:
2083:
2082:
2072:
2040:
2034:
2033:
2023:
1999:
1993:
1992:
1982:
1973:(10): 2198–205.
1958:
1952:
1951:
1941:
1909:
1903:
1902:
1895:
1889:
1888:
1886:
1885:
1870:
1859:
1858:
1848:
1816:
1807:
1806:
1796:
1786:
1754:
1748:
1747:
1736:
1730:
1729:
1718:
1712:
1702:
1691:
1681:
1613:As a drug target
1603:cloverleaf skull
1559:gain-of-function
1479:craniosynostosis
1452:craniosynostosis
1317:
1316:
1288:
1281:
1264:
1254:
1253:
1245:
1217:
1216:
1213:RefSeq (protein)
1203:
1167:
1166:
1158:
1130:
1129:
1106:
1105:
1087:
1086:
1061:
1060:
1042:
1041:
1016:
1015:
997:
996:
966:
965:
774:receptor complex
606:
605:
592:
583:
576:
569:
568:
554:
502:ventricular zone
494:
492:Top expressed in
487:
486:
432:
430:Top expressed in
425:
424:
404:
403:
387:
386:
377:
364:
353:
338:
331:
325:
314:
302:
286:
285:
276:
263:
252:
237:
230:
224:
213:
199:
183:
182:
177:
128:
121:
98:
77:
76:
71:
50:
49:
44:
32:
31:
21:
9623:
9622:
9618:
9617:
9616:
9614:
9613:
9612:
9588:
9587:
9586:
9574:
9566:
9564:
9559:
9504:Midkine (NEGF2)
9382:
9165:
9064:
8833:
8771:ABT-110 (PG110)
8564:
8544:
8454:
8435:
8404:
8373:
8342:
8297:
8149:
8087:ABT-110 (PG110)
7988:
7925:
7887:
7745:
7559:
7540:
7480:
7477:(against FGF23)
7399:
7266:
7170:
7113:
7059:
6972:
6783:
6767:
6736:
6658:
6650:
6620:
6615:
6527:Oxidoreductases
6513:
6489:Enzyme kinetics
6477:
6473:List of enzymes
6446:
6415:
6386:Catalytic triad
6364:
6359:
6329:
6316:
6292:
6253:
6222:
6191:
6157:
6128:
6104:
6080:
6056:
6032:
6004:
5982:
5966:
5947:
5918:
5894:
5878:
5859:
5840:
5821:
5797:
5773:
5749:
5725:
5632:
5603:
5579:
5550:
5516:
5473:
5444:
5398:
5384:
5373:Protein kinases
5370:
5340:
5335:
5139:
4933:
4682:
4366:
4089:
3749:
3347:
3333:
3303:
3298:
3280:Other/ungrouped
3275:
3240:
3214:
3184:
3167:
3147:
3134:
3097:
3053:
2985:
2958:
2949:
2919:
2914:
2911:
2905:
2891:
2888:
2797:
2792:
2555:
2553:Further reading
2550:
2549:
2512:
2505:
2468:
2461:
2401:
2397:
2387:
2385:
2377:
2376:
2372:
2362:
2360:
2351:
2350:
2346:
2307:
2303:
2291:
2290:
2281:
2280:
2274:
2272:
2256:
2247:
2237:
2235:
2227:
2226:
2219:
2206:
2205:
2198:
2185:
2184:
2180:
2133:
2129:
2100:(12): 858–866.
2090:
2086:
2055:(19): 2243–63.
2041:
2037:
2000:
1996:
1959:
1955:
1910:
1906:
1897:
1896:
1892:
1883:
1881:
1872:
1871:
1862:
1817:
1810:
1755:
1751:
1738:
1737:
1733:
1720:
1719:
1715:
1703:
1694:
1682:
1673:
1668:
1651:
1631:
1615:
1607:frontal bossing
1571:Muenke syndrome
1568:
1566:Muenke syndrome
1552:
1536:
1524:
1502:fusion proteins
1491:
1475:
1473:Disease linkage
1447:
1416:tyrosine kinase
1392:
1326:View/Edit Mouse
1321:View/Edit Human
1284:
1277:
1274:Location (UCSC)
1262:
1241:
1237:
1233:
1229:
1225:
1199:
1195:
1189:
1185:
1181:
1177:
1173:
1154:
1150:
1146:
1142:
1138:
1051:ENSG00000068078
944:
825:bone maturation
800:phosphorylation
778:
734:plasma membrane
719:Golgi apparatus
697:
643:protein binding
638:kinase activity
588:
578:
577:
550:
541:
538:mammillary body
536:
532:
528:
524:
520:
516:
512:
508:
504:
490:
479:
476:skin of abdomen
474:
470:
466:
462:
458:
454:
450:
446:
442:
428:
372:
359:
351:
341:
340:
339:
332:
312:
289:Gene location (
271:
258:
250:
240:
239:
238:
231:
209:
186:Gene location (
137:
124:
117:
86:
64:
28:
23:
22:
15:
12:
11:
5:
9621:
9611:
9610:
9605:
9600:
9585:
9584:
9561:
9560:
9558:
9557:
9547:
9546:
9541:
9534:Thrombopoietin
9531:
9526:
9521:
9516:
9511:
9506:
9501:
9496:
9491:
9477:
9472:
9467:
9462:
9455:Erythropoietin
9452:
9414:
9409:
9399:
9397:Adrenomedullin
9390:
9388:
9384:
9383:
9381:
9380:
9371:
9370:
9365:
9360:
9355:
9350:
9341:
9340:
9335:
9330:
9325:
9320:
9315:
9310:
9305:
9300:
9295:
9290:
9285:
9280:
9275:
9270:
9265:
9260:
9255:
9250:
9245:
9240:
9231:
9230:
9221:
9220:
9198:
9193:
9188:
9179:
9177:
9171:
9170:
9167:
9166:
9164:
9163:
9158:
9153:
9148:
9143:
9138:
9133:
9128:
9123:
9118:
9113:
9108:
9103:
9094:
9093:
9088:
9083:
9074:
9072:
9066:
9065:
9063:
9062:
9057:
9052:
9047:
9042:
9037:
9032:
9027:
9022:
9017:
9012:
9007:
9002:
8993:
8992:
8983:
8982:
8977:
8972:
8963:
8962:
8957:
8952:
8947:
8942:
8937:
8932:
8927:
8922:
8917:
8912:
8907:
8902:
8897:
8892:
8887:
8882:
8877:
8872:
8867:
8862:
8860:4'-DMA-7,8-DHF
8857:
8852:
8843:
8841:
8835:
8834:
8832:
8831:
8822:
8821:
8809:
8808:
8803:
8798:
8793:
8788:
8783:
8778:
8773:
8754:
8753:
8747:
8742:
8737:
8732:
8727:
8722:
8717:
8712:
8707:
8702:
8697:
8692:
8687:
8682:
8677:
8668:
8667:
8658:
8657:
8652:
8647:
8642:
8633:
8632:
8627:
8622:
8620:Gambogic amide
8617:
8612:
8607:
8602:
8597:
8592:
8583:
8581:
8572:
8566:
8565:
8563:
8562:
8554:
8552:
8546:
8545:
8543:
8542:
8537:
8532:
8527:
8522:
8517:
8512:
8507:
8502:
8497:
8492:
8483:
8482:
8477:
8468:
8466:
8460:
8459:
8456:
8455:
8453:
8452:
8443:
8441:
8437:
8436:
8434:
8433:
8424:
8423:
8414:
8412:
8406:
8405:
8403:
8402:
8393:
8392:
8390:Artemin (ARTN)
8383:
8381:
8375:
8374:
8372:
8371:
8362:
8361:
8352:
8350:
8344:
8343:
8341:
8340:
8331:
8330:
8325:
8316:
8314:
8305:
8299:
8298:
8296:
8295:
8290:
8285:
8276:
8275:
8270:
8265:
8260:
8255:
8250:
8245:
8240:
8235:
8230:
8225:
8220:
8215:
8210:
8205:
8200:
8191:
8190:
8168:
8159:
8157:
8151:
8150:
8148:
8147:
8138:
8137:
8125:
8124:
8119:
8114:
8109:
8104:
8099:
8094:
8089:
8077:
8076:
8071:
8066:
8061:
8052:
8051:
8046:
8041:
8036:
8031:
8026:
8021:
8016:
8011:
8002:
8000:
7994:
7993:
7990:
7989:
7987:
7986:
7981:
7972:
7971:
7933:
7931:
7927:
7926:
7924:
7923:
7917:
7908:
7907:
7897:
7895:
7889:
7888:
7886:
7885:
7879:
7874:
7869:
7864:
7859:
7854:
7849:
7844:
7835:
7834:
7829:
7824:
7819:
7814:
7805:
7804:
7799:
7794:
7789:
7784:
7779:
7774:
7764:
7762:
7753:
7747:
7746:
7744:
7743:
7738:
7733:
7728:
7723:
7718:
7713:
7704:
7703:
7698:
7693:
7688:
7683:
7678:
7673:
7668:
7663:
7658:
7653:
7648:
7643:
7638:
7633:
7628:
7623:
7618:
7613:
7608:
7599:
7598:
7589:
7588:
7583:
7573:
7571:
7565:
7564:
7561:
7560:
7558:
7557:
7548:
7546:
7542:
7541:
7539:
7538:
7533:
7499:
7490:
7488:
7482:
7481:
7479:
7478:
7468:
7467:
7462:
7457:
7452:
7418:
7409:
7407:
7401:
7400:
7398:
7397:
7388:
7387:
7382:
7373:
7372:
7367:
7362:
7357:
7352:
7347:
7285:
7276:
7274:
7268:
7267:
7265:
7264:
7259:
7254:
7249:
7244:
7202:
7193:
7191:
7182:
7176:
7175:
7172:
7171:
7169:
7168:
7142:
7137:
7132:
7123:
7121:
7115:
7114:
7112:
7111:
7106:
7101:
7092:
7091:
7069:
7067:
7061:
7060:
7058:
7057:
7052:
7047:
7042:
7037:
7028:
7027:
7022:
7017:
7012:
7007:
7002:
6993:
6992:
6982:
6980:
6974:
6973:
6971:
6970:
6965:
6960:
6955:
6950:
6945:
6940:
6935:
6930:
6925:
6916:
6915:
6910:
6905:
6900:
6895:
6890:
6885:
6880:
6875:
6870:
6865:
6860:
6855:
6850:
6841:
6840:
6835:
6830:
6825:
6820:
6815:
6810:
6805:
6800:
6790:
6788:
6775:
6769:
6768:
6766:
6765:
6760:
6755:
6746:
6744:
6738:
6737:
6735:
6734:
6728:
6718:
6717:
6712:
6707:
6698:
6697:
6695:Angiopoietin 3
6692:
6690:Angiopoietin 2
6683:
6682:
6680:Angiopoietin 4
6677:
6675:Angiopoietin 1
6668:
6666:
6660:
6659:
6649:
6648:
6641:
6634:
6626:
6617:
6616:
6614:
6613:
6600:
6587:
6574:
6561:
6548:
6535:
6521:
6519:
6515:
6514:
6512:
6511:
6506:
6501:
6496:
6491:
6485:
6483:
6479:
6478:
6476:
6475:
6470:
6465:
6460:
6454:
6452:
6451:Classification
6448:
6447:
6445:
6444:
6439:
6434:
6429:
6423:
6421:
6417:
6416:
6414:
6413:
6408:
6403:
6398:
6393:
6388:
6383:
6378:
6372:
6370:
6366:
6365:
6358:
6357:
6350:
6343:
6335:
6326:
6325:
6322:
6321:
6318:
6317:
6315:
6314:
6309:
6303:
6301:
6294:
6293:
6291:
6290:
6285:
6280:
6275:
6270:
6264:
6262:
6255:
6254:
6252:
6251:
6246:
6241:
6236:
6230:
6228:
6224:
6223:
6221:
6220:
6215:
6210:
6205:
6199:
6197:
6193:
6192:
6190:
6189:
6184:
6179:
6174:
6168:
6166:
6159:
6158:
6156:
6155:
6150:
6145:
6139:
6137:
6130:
6129:
6127:
6126:
6121:
6115:
6113:
6106:
6105:
6103:
6102:
6097:
6091:
6089:
6082:
6081:
6079:
6078:
6073:
6067:
6065:
6058:
6057:
6055:
6054:
6049:
6043:
6041:
6034:
6033:
6031:
6030:
6025:
6019:
6017:
6006:
6005:
5992:
5991:
5988:
5987:
5984:
5983:
5981:
5980:
5974:
5972:
5968:
5967:
5965:
5964:
5958:
5956:
5949:
5948:
5946:
5945:
5940:
5935:
5929:
5927:
5920:
5919:
5917:
5916:
5911:
5905:
5903:
5900:AATYK receptor
5896:
5895:
5893:
5892:
5886:
5884:
5880:
5879:
5877:
5876:
5870:
5868:
5861:
5860:
5858:
5857:
5851:
5849:
5842:
5841:
5839:
5838:
5832:
5830:
5823:
5822:
5820:
5819:
5814:
5808:
5806:
5799:
5798:
5796:
5795:
5790:
5784:
5782:
5775:
5774:
5772:
5771:
5766:
5760:
5758:
5751:
5750:
5748:
5747:
5742:
5736:
5734:
5727:
5726:
5724:
5723:
5718:
5713:
5708:
5703:
5698:
5693:
5688:
5683:
5678:
5673:
5668:
5663:
5658:
5653:
5647:
5645:
5638:
5637:
5634:
5633:
5631:
5630:
5625:
5620:
5614:
5612:
5605:
5604:
5602:
5601:
5596:
5590:
5588:
5581:
5580:
5578:
5577:
5572:
5567:
5561:
5559:
5556:VEGF receptors
5552:
5551:
5549:
5548:
5543:
5538:
5533:
5527:
5525:
5518:
5517:
5515:
5514:
5508:
5499:
5494:
5489:
5483:
5481:
5475:
5474:
5472:
5471:
5466:
5461:
5455:
5453:
5446:
5445:
5443:
5442:
5437:
5432:
5427:
5421:
5419:
5410:
5400:
5399:
5386:
5385:
5369:
5368:
5361:
5354:
5346:
5337:
5336:
5334:
5333:
5328:
5323:
5318:
5313:
5308:
5303:
5298:
5293:
5288:
5283:
5278:
5273:
5268:
5263:
5258:
5253:
5248:
5243:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5203:
5198:
5193:
5188:
5183:
5178:
5173:
5168:
5163:
5158:
5153:
5147:
5145:
5141:
5140:
5138:
5137:
5132:
5127:
5122:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5057:
5052:
5047:
5042:
5037:
5032:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4941:
4939:
4935:
4934:
4932:
4931:
4926:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4872:
4871:
4870:
4865:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4810:
4805:
4800:
4795:
4790:
4784:
4775:
4770:
4769:
4768:
4763:
4753:
4748:
4747:
4746:
4741:
4731:
4726:
4721:
4716:
4711:
4706:
4701:
4696:
4690:
4688:
4684:
4683:
4681:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4595:
4594:
4593:
4588:
4578:
4573:
4568:
4563:
4562:
4561:
4556:
4551:
4541:
4536:
4531:
4526:
4521:
4520:
4519:
4514:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4473:
4472:
4467:
4457:
4451:
4446:
4441:
4436:
4427:
4422:
4421:
4420:
4415:
4410:
4400:
4395:
4390:
4385:
4380:
4374:
4372:
4368:
4367:
4365:
4364:
4359:
4354:
4349:
4344:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4269:
4264:
4259:
4254:
4249:
4244:
4239:
4238:
4237:
4232:
4222:
4221:
4220:
4215:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4144:
4143:
4138:
4128:
4123:
4118:
4113:
4108:
4103:
4097:
4095:
4091:
4090:
4088:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4052:
4047:
4038:
4033:
4028:
4023:
4018:
4013:
4012:
4011:
4006:
4001:
3996:
3991:
3986:
3976:
3971:
3966:
3961:
3956:
3951:
3950:
3949:
3944:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3899:
3894:
3893:
3892:
3887:
3882:
3877:
3872:
3867:
3857:
3856:
3855:
3850:
3845:
3835:
3830:
3829:
3828:
3823:
3818:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3757:
3755:
3751:
3750:
3748:
3747:
3742:
3741:
3740:
3735:
3730:
3725:
3720:
3715:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3674:
3673:
3668:
3663:
3658:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3602:
3601:
3596:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3515:
3514:
3509:
3499:
3494:
3489:
3484:
3483:
3482:
3477:
3472:
3467:
3457:
3452:
3447:
3446:
3445:
3435:
3430:
3425:
3420:
3415:
3414:
3413:
3408:
3403:
3393:
3388:
3387:
3386:
3381:
3376:
3371:
3366:
3355:
3353:
3349:
3348:
3332:
3331:
3324:
3317:
3309:
3300:
3299:
3297:
3296:
3295:
3294:
3283:
3281:
3277:
3276:
3274:
3273:
3268:
3267:
3266:
3261:
3250:
3248:
3246:Ig superfamily
3242:
3241:
3239:
3238:
3228:
3226:
3220:
3219:
3216:
3215:
3213:
3212:
3211:
3210:
3205:
3200:
3189:
3186:
3185:
3183:
3182:
3172:
3169:
3168:
3166:
3165:
3164:
3163:
3152:
3149:
3148:
3146:
3145:
3139:
3136:
3135:
3133:
3132:
3131:
3130:
3125:
3120:
3110:high affinity
3102:
3099:
3098:
3096:
3095:
3094:
3093:
3088:
3083:
3078:
3067:
3061:
3055:
3054:
3052:
3051:
3050:
3049:
3044:
3034:
3033:
3032:
3027:
3017:
3016:
3015:
3010:
2995:
2993:
2987:
2986:
2984:
2983:
2981:Erythropoietin
2978:
2968:
2966:
2960:
2959:
2948:
2947:
2940:
2933:
2925:
2916:
2915:
2913:
2912:
2906:
2899:
2896:
2893:
2892:
2887:
2886:
2879:
2872:
2864:
2845:
2844:
2823:
2813:
2808:
2803:
2796:
2795:External links
2793:
2791:
2790:
2737:
2702:
2682:(11): 954–61.
2667:
2630:
2600:
2572:(10): 1551–9.
2556:
2554:
2551:
2548:
2547:
2503:
2482:(3): 1726–31.
2459:
2457:
2456:
2415:(7): 812–821.
2395:
2370:
2344:
2301:
2245:
2217:
2196:
2178:
2127:
2084:
2035:
1994:
1967:Carcinogenesis
1953:
1918:Human Mutation
1904:
1890:
1860:
1808:
1749:
1731:
1713:
1692:
1670:
1669:
1667:
1664:
1663:
1662:
1657:
1650:
1647:
1630:
1627:
1614:
1611:
1567:
1564:
1551:
1548:
1539:Achondroplasia
1535:
1534:Achondroplasia
1532:
1523:
1520:
1506:bladder cancer
1490:
1489:Bladder cancer
1487:
1474:
1471:
1446:
1443:
1408:immunoglobulin
1398:family, where
1391:
1388:
1380:achondroplasia
1333:
1332:
1329:
1328:
1323:
1313:
1312:
1306:
1305:
1302:
1301:
1299:
1297:
1290:
1289:
1282:
1275:
1271:
1270:
1267:
1266:
1258:
1257:
1251:
1248:
1247:
1221:
1220:
1214:
1210:
1209:
1206:
1205:
1191:
1190:
1164:
1161:
1160:
1134:
1133:
1127:
1123:
1122:
1119:
1118:
1110:
1109:
1103:
1100:
1099:
1091:
1090:
1084:
1078:
1077:
1074:
1073:
1065:
1064:
1058:
1055:
1054:
1046:
1045:
1039:
1033:
1032:
1029:
1028:
1020:
1019:
1013:
1010:
1009:
1001:
1000:
994:
988:
987:
982:
977:
973:
972:
962:
961:
958:
957:
946:
945:
943:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
786:
784:
780:
779:
777:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
729:focal adhesion
726:
721:
716:
711:
705:
703:
699:
698:
696:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
619:
617:
613:
612:
602:
601:
598:
597:
594:
593:
585:
584:
566:
560:
559:
556:
555:
547:
546:
543:
542:
540:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
496:
495:
484:
481:
480:
478:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
434:
433:
421:
420:
412:
401:
395:
394:
391:RNA expression
383:
382:
379:
378:
370:
366:
365:
357:
354:
349:
343:
342:
333:
326:
320:
316:
315:
310:
304:
303:
295:
294:
282:
281:
278:
277:
269:
265:
264:
256:
253:
248:
242:
241:
232:
225:
219:
215:
214:
207:
201:
200:
192:
191:
179:
178:
135:
131:
130:
122:
114:
113:
109:
108:
105:
104:
101:
100:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
9:
6:
4:
3:
2:
9620:
9609:
9606:
9604:
9601:
9599:
9596:
9595:
9593:
9583:
9578:
9573:
9572:
9569:
9555:
9552:
9549:
9548:
9545:
9542:
9539:
9535:
9532:
9530:
9527:
9525:
9522:
9520:
9517:
9515:
9512:
9510:
9507:
9505:
9502:
9500:
9497:
9495:
9492:
9489:
9485:
9481:
9478:
9476:
9473:
9471:
9468:
9466:
9463:
9460:
9456:
9453:
9450:
9446:
9442:
9438:
9434:
9430:
9426:
9422:
9418:
9415:
9413:
9410:
9407:
9403:
9400:
9398:
9395:
9392:
9391:
9389:
9385:
9379:
9376:
9373:
9372:
9369:
9366:
9364:
9361:
9359:
9356:
9354:
9351:
9349:
9346:
9343:
9342:
9339:
9336:
9334:
9331:
9329:
9326:
9324:
9321:
9319:
9316:
9314:
9311:
9309:
9306:
9304:
9301:
9299:
9296:
9294:
9291:
9289:
9286:
9284:
9281:
9279:
9276:
9274:
9271:
9269:
9266:
9264:
9261:
9259:
9256:
9254:
9251:
9249:
9246:
9244:
9241:
9239:
9236:
9233:
9232:
9229:
9228:Cyclotraxin B
9226:
9223:
9222:
9218:
9214:
9210:
9206:
9202:
9199:
9197:
9194:
9192:
9189:
9187:
9184:
9181:
9180:
9178:
9176:
9172:
9162:
9159:
9157:
9154:
9152:
9149:
9147:
9144:
9142:
9141:Larotrectinib
9139:
9137:
9134:
9132:
9129:
9127:
9124:
9122:
9119:
9117:
9114:
9112:
9109:
9107:
9104:
9102:
9099:
9096:
9095:
9092:
9089:
9087:
9084:
9082:
9079:
9076:
9075:
9073:
9071:
9067:
9061:
9058:
9056:
9053:
9051:
9048:
9046:
9043:
9041:
9040:Larotrectinib
9038:
9036:
9033:
9031:
9028:
9026:
9023:
9021:
9018:
9016:
9013:
9011:
9008:
9006:
9003:
9001:
8998:
8995:
8994:
8991:
8988:
8985:
8984:
8981:
8978:
8976:
8975:Cyclotraxin B
8973:
8971:
8968:
8965:
8964:
8961:
8958:
8956:
8953:
8951:
8948:
8946:
8943:
8941:
8938:
8936:
8933:
8931:
8928:
8926:
8923:
8921:
8918:
8916:
8913:
8911:
8908:
8906:
8903:
8901:
8898:
8896:
8893:
8891:
8888:
8886:
8885:Amitriptyline
8883:
8881:
8878:
8876:
8873:
8871:
8868:
8866:
8863:
8861:
8858:
8856:
8853:
8851:
8848:
8845:
8844:
8842:
8840:
8836:
8830:
8827:
8824:
8823:
8820:
8817:
8814:
8811:
8810:
8807:
8804:
8802:
8799:
8797:
8794:
8792:
8789:
8787:
8784:
8782:
8779:
8777:
8774:
8772:
8769:
8765:
8762:
8761:Against TrkA:
8759:
8756:
8755:
8751:
8748:
8746:
8743:
8741:
8738:
8736:
8733:
8731:
8728:
8726:
8723:
8721:
8718:
8716:
8715:Larotrectinib
8713:
8711:
8708:
8706:
8703:
8701:
8698:
8696:
8693:
8691:
8688:
8686:
8683:
8681:
8678:
8676:
8673:
8670:
8669:
8666:
8663:
8660:
8659:
8656:
8653:
8651:
8648:
8646:
8645:Dexamethasone
8643:
8641:
8638:
8635:
8634:
8631:
8628:
8626:
8623:
8621:
8618:
8616:
8613:
8611:
8608:
8606:
8603:
8601:
8598:
8596:
8593:
8591:
8590:Amitriptyline
8588:
8585:
8584:
8582:
8580:
8576:
8573:
8571:
8567:
8560:
8556:
8555:
8553:
8551:
8547:
8541:
8538:
8536:
8533:
8531:
8528:
8526:
8523:
8521:
8518:
8516:
8513:
8511:
8508:
8506:
8503:
8501:
8498:
8496:
8493:
8491:
8488:
8485:
8484:
8481:
8478:
8476:
8473:
8470:
8469:
8467:
8465:
8461:
8451:
8448:
8445:
8444:
8442:
8438:
8432:
8429:
8426:
8425:
8422:
8419:
8416:
8415:
8413:
8411:
8407:
8401:
8398:
8395:
8394:
8391:
8388:
8385:
8384:
8382:
8380:
8376:
8370:
8367:
8364:
8363:
8360:
8357:
8354:
8353:
8351:
8349:
8345:
8339:
8336:
8333:
8332:
8329:
8326:
8324:
8321:
8318:
8317:
8315:
8313:
8309:
8306:
8304:
8300:
8294:
8291:
8289:
8286:
8284:
8281:
8278:
8277:
8274:
8271:
8269:
8266:
8264:
8261:
8259:
8256:
8254:
8251:
8249:
8246:
8244:
8241:
8239:
8236:
8234:
8231:
8229:
8226:
8224:
8221:
8219:
8216:
8214:
8211:
8209:
8206:
8204:
8201:
8199:
8196:
8193:
8192:
8188:
8184:
8180:
8176:
8172:
8169:
8167:
8164:
8161:
8160:
8158:
8156:
8152:
8146:
8143:
8140:
8139:
8136:
8133:
8130:
8127:
8126:
8123:
8120:
8118:
8115:
8113:
8110:
8108:
8105:
8103:
8100:
8098:
8095:
8093:
8090:
8088:
8085:
8082:
8079:
8078:
8075:
8072:
8070:
8067:
8065:
8064:Dexamethasone
8062:
8060:
8057:
8054:
8053:
8050:
8047:
8045:
8042:
8040:
8037:
8035:
8032:
8030:
8027:
8025:
8022:
8020:
8017:
8015:
8012:
8010:
8007:
8004:
8003:
8001:
7999:
7995:
7985:
7982:
7980:
7977:
7974:
7973:
7969:
7965:
7961:
7957:
7953:
7949:
7945:
7941:
7938:
7935:
7934:
7932:
7928:
7921:
7918:
7916:
7913:
7910:
7909:
7906:
7902:
7899:
7898:
7896:
7894:
7890:
7883:
7880:
7878:
7875:
7873:
7870:
7868:
7865:
7863:
7860:
7858:
7855:
7853:
7850:
7848:
7845:
7843:
7840:
7837:
7836:
7833:
7830:
7828:
7825:
7823:
7820:
7818:
7815:
7813:
7810:
7807:
7806:
7803:
7800:
7798:
7795:
7793:
7790:
7788:
7785:
7783:
7780:
7778:
7775:
7773:
7772:des(1-3)IGF-1
7769:
7766:
7765:
7763:
7761:
7757:
7754:
7752:
7748:
7742:
7739:
7737:
7736:Telisotuzumab
7734:
7732:
7729:
7727:
7724:
7722:
7719:
7717:
7714:
7712:
7709:
7706:
7705:
7702:
7699:
7697:
7694:
7692:
7689:
7687:
7684:
7682:
7679:
7677:
7674:
7672:
7669:
7667:
7664:
7662:
7659:
7657:
7654:
7652:
7649:
7647:
7644:
7642:
7639:
7637:
7634:
7632:
7629:
7627:
7624:
7622:
7619:
7617:
7614:
7612:
7609:
7607:
7604:
7601:
7600:
7597:
7594:
7593:Potentiators:
7591:
7590:
7587:
7584:
7582:
7578:
7575:
7574:
7572:
7570:
7566:
7556:
7553:
7550:
7549:
7547:
7543:
7537:
7534:
7531:
7527:
7523:
7519:
7515:
7511:
7507:
7503:
7500:
7498:
7495:
7492:
7491:
7489:
7487:
7483:
7476:
7473:
7470:
7469:
7466:
7463:
7461:
7458:
7456:
7455:Selpercatinib
7453:
7450:
7446:
7442:
7438:
7434:
7430:
7426:
7422:
7419:
7417:
7414:
7411:
7410:
7408:
7406:
7402:
7396:
7393:
7390:
7389:
7386:
7383:
7381:
7378:
7375:
7374:
7371:
7368:
7366:
7363:
7361:
7360:Selpercatinib
7358:
7356:
7353:
7351:
7348:
7345:
7341:
7337:
7333:
7329:
7325:
7321:
7317:
7313:
7309:
7305:
7301:
7297:
7293:
7289:
7286:
7284:
7281:
7278:
7277:
7275:
7273:
7269:
7263:
7260:
7258:
7255:
7253:
7252:Selpercatinib
7250:
7248:
7245:
7242:
7238:
7234:
7230:
7226:
7222:
7218:
7214:
7210:
7206:
7203:
7201:
7198:
7195:
7194:
7192:
7190:
7186:
7183:
7181:
7177:
7166:
7162:
7158:
7154:
7150:
7146:
7143:
7141:
7138:
7136:
7133:
7131:
7128:
7125:
7124:
7122:
7120:
7116:
7110:
7107:
7105:
7102:
7100:
7097:
7094:
7093:
7089:
7085:
7081:
7077:
7074:
7071:
7070:
7068:
7066:
7062:
7056:
7053:
7051:
7048:
7046:
7043:
7041:
7038:
7036:
7033:
7030:
7029:
7026:
7023:
7021:
7018:
7016:
7013:
7011:
7008:
7006:
7003:
7001:
6998:
6995:
6994:
6991:
6987:
6984:
6983:
6981:
6979:
6975:
6969:
6966:
6964:
6961:
6959:
6956:
6954:
6951:
6949:
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6928:Depatuxizumab
6926:
6924:
6921:
6918:
6917:
6914:
6911:
6909:
6906:
6904:
6901:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6879:
6876:
6874:
6871:
6869:
6866:
6864:
6861:
6859:
6856:
6854:
6851:
6849:
6846:
6843:
6842:
6839:
6836:
6834:
6831:
6829:
6826:
6824:
6821:
6819:
6816:
6814:
6811:
6809:
6806:
6804:
6801:
6799:
6795:
6792:
6791:
6789:
6787:
6779:
6776:
6774:
6770:
6764:
6761:
6759:
6756:
6754:
6751:
6748:
6747:
6745:
6743:
6739:
6732:
6729:
6726:
6723:
6720:
6719:
6716:
6713:
6711:
6708:
6706:
6703:
6700:
6699:
6696:
6693:
6691:
6688:
6685:
6684:
6681:
6678:
6676:
6673:
6670:
6669:
6667:
6665:
6661:
6657:
6654:
6647:
6642:
6640:
6635:
6633:
6628:
6627:
6624:
6611:
6607:
6606:
6601:
6598:
6594:
6593:
6588:
6585:
6581:
6580:
6575:
6572:
6568:
6567:
6562:
6559:
6555:
6554:
6549:
6546:
6542:
6541:
6536:
6533:
6529:
6528:
6523:
6522:
6520:
6516:
6510:
6507:
6505:
6502:
6500:
6497:
6495:
6492:
6490:
6487:
6486:
6484:
6480:
6474:
6471:
6469:
6468:Enzyme family
6466:
6464:
6461:
6459:
6456:
6455:
6453:
6449:
6443:
6440:
6438:
6435:
6433:
6432:Cooperativity
6430:
6428:
6425:
6424:
6422:
6418:
6412:
6409:
6407:
6404:
6402:
6399:
6397:
6394:
6392:
6391:Oxyanion hole
6389:
6387:
6384:
6382:
6379:
6377:
6374:
6373:
6371:
6367:
6363:
6356:
6351:
6349:
6344:
6342:
6337:
6336:
6333:
6313:
6310:
6308:
6305:
6304:
6302:
6299:
6295:
6289:
6286:
6284:
6281:
6279:
6276:
6274:
6271:
6269:
6266:
6265:
6263:
6260:
6256:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6231:
6229:
6225:
6219:
6216:
6214:
6211:
6209:
6206:
6204:
6201:
6200:
6198:
6194:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6169:
6167:
6164:
6160:
6154:
6151:
6149:
6146:
6144:
6141:
6140:
6138:
6135:
6131:
6125:
6122:
6120:
6117:
6116:
6114:
6111:
6107:
6101:
6098:
6096:
6093:
6092:
6090:
6087:
6083:
6077:
6074:
6072:
6069:
6068:
6066:
6063:
6059:
6053:
6050:
6048:
6045:
6044:
6042:
6039:
6035:
6029:
6026:
6024:
6021:
6020:
6018:
6015:
6011:
6007:
6003:(EC 2.7.10.2)
6002:
5997:
5993:
5979:
5976:
5975:
5973:
5971:uncategorised
5969:
5963:
5960:
5959:
5957:
5954:
5950:
5944:
5941:
5939:
5936:
5934:
5931:
5930:
5928:
5925:
5921:
5915:
5912:
5910:
5907:
5906:
5904:
5901:
5897:
5891:
5888:
5887:
5885:
5881:
5875:
5872:
5871:
5869:
5866:
5865:MuSK receptor
5862:
5856:
5853:
5852:
5850:
5847:
5843:
5837:
5834:
5833:
5831:
5828:
5827:PTK7 receptor
5824:
5818:
5815:
5813:
5810:
5809:
5807:
5804:
5800:
5794:
5791:
5789:
5786:
5785:
5783:
5780:
5776:
5770:
5767:
5765:
5762:
5761:
5759:
5756:
5752:
5746:
5743:
5741:
5738:
5737:
5735:
5732:
5728:
5722:
5719:
5717:
5714:
5712:
5709:
5707:
5704:
5702:
5699:
5697:
5694:
5692:
5689:
5687:
5684:
5682:
5679:
5677:
5674:
5672:
5669:
5667:
5664:
5662:
5659:
5657:
5654:
5652:
5649:
5648:
5646:
5643:
5639:
5629:
5626:
5624:
5621:
5619:
5616:
5615:
5613:
5610:
5606:
5600:
5597:
5595:
5592:
5591:
5589:
5586:
5582:
5576:
5573:
5571:
5568:
5566:
5563:
5562:
5560:
5557:
5553:
5547:
5544:
5542:
5539:
5537:
5534:
5532:
5529:
5528:
5526:
5523:
5519:
5512:
5509:
5507:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5484:
5482:
5480:
5476:
5470:
5467:
5465:
5462:
5460:
5457:
5456:
5454:
5451:
5447:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5422:
5420:
5418:
5414:
5411:
5409:
5405:
5401:
5397:(EC 2.7.10.1)
5396:
5391:
5387:
5382:
5378:
5374:
5367:
5362:
5360:
5355:
5353:
5348:
5347:
5344:
5332:
5329:
5327:
5324:
5322:
5319:
5317:
5314:
5312:
5309:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5177:
5174:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5152:
5149:
5148:
5146:
5142:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4942:
4940:
4936:
4930:
4927:
4925:
4921:
4918:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4869:
4866:
4864:
4861:
4860:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4804:
4801:
4799:
4796:
4794:
4791:
4788:
4785:
4783:
4779:
4776:
4774:
4771:
4767:
4764:
4762:
4759:
4758:
4757:
4754:
4752:
4749:
4745:
4742:
4740:
4737:
4736:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4691:
4689:
4685:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4592:
4589:
4587:
4584:
4583:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4560:
4557:
4555:
4552:
4550:
4547:
4546:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4518:
4515:
4513:
4510:
4509:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4471:
4468:
4466:
4463:
4462:
4461:
4458:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4431:
4428:
4426:
4423:
4419:
4416:
4414:
4411:
4409:
4406:
4405:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4375:
4373:
4369:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4236:
4233:
4231:
4228:
4227:
4226:
4223:
4219:
4216:
4214:
4211:
4210:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4142:
4139:
4137:
4134:
4133:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4098:
4096:
4092:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3981:
3980:
3977:
3975:
3972:
3970:
3967:
3965:
3962:
3960:
3957:
3955:
3952:
3948:
3945:
3943:
3940:
3939:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3862:
3861:
3858:
3854:
3851:
3849:
3846:
3844:
3841:
3840:
3839:
3836:
3834:
3831:
3827:
3824:
3822:
3819:
3817:
3814:
3813:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3758:
3756:
3752:
3746:
3743:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3710:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3653:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3600:
3597:
3595:
3592:
3591:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3513:
3510:
3508:
3505:
3504:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3462:
3461:
3458:
3456:
3453:
3451:
3448:
3444:
3441:
3440:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3412:
3409:
3407:
3404:
3402:
3399:
3398:
3397:
3394:
3392:
3389:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3361:
3360:
3357:
3356:
3354:
3350:
3345:
3341:
3337:
3330:
3325:
3323:
3318:
3316:
3311:
3310:
3307:
3293:
3290:
3289:
3288:
3285:
3284:
3282:
3278:
3272:
3269:
3265:
3262:
3260:
3257:
3256:
3255:
3252:
3251:
3249:
3247:
3243:
3237:
3233:
3230:
3229:
3227:
3225:
3221:
3209:
3206:
3204:
3201:
3199:
3196:
3195:
3194:
3191:
3190:
3187:
3181:
3177:
3174:
3173:
3170:
3162:
3159:
3158:
3157:
3154:
3153:
3150:
3144:
3141:
3140:
3137:
3129:
3126:
3124:
3121:
3119:
3116:
3115:
3114:
3113:
3107:
3104:
3103:
3100:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3073:
3072:
3069:
3068:
3065:
3062:
3060:
3056:
3048:
3045:
3043:
3040:
3039:
3038:
3035:
3031:
3028:
3026:
3023:
3022:
3021:
3018:
3014:
3011:
3009:
3006:
3005:
3004:
3000:
2997:
2996:
2994:
2992:
2988:
2982:
2979:
2977:
2973:
2970:
2969:
2967:
2965:
2961:
2957:
2953:
2946:
2941:
2939:
2934:
2932:
2927:
2926:
2923:
2909:
2903:
2898:
2897:
2894:
2885:
2880:
2878:
2873:
2871:
2866:
2865:
2862:
2858:
2857:
2855:
2854:public domain
2851:
2842:
2838:
2837:
2832:
2828:
2824:
2821:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2798:
2787:
2783:
2778:
2773:
2768:
2763:
2759:
2755:
2752:(4): 935–40.
2751:
2747:
2743:
2738:
2734:
2730:
2725:
2720:
2717:(7): 1664–6.
2716:
2712:
2708:
2703:
2699:
2695:
2690:
2685:
2681:
2677:
2673:
2668:
2664:
2660:
2656:
2652:
2648:
2644:
2640:
2636:
2631:
2627:
2623:
2619:
2615:
2611:
2607:
2601:
2597:
2593:
2588:
2583:
2579:
2575:
2571:
2567:
2563:
2558:
2557:
2543:
2539:
2534:
2529:
2525:
2521:
2517:
2510:
2508:
2499:
2495:
2490:
2485:
2481:
2477:
2473:
2466:
2464:
2453:
2449:
2444:
2443:
2440:
2436:
2431:
2426:
2422:
2418:
2414:
2410:
2406:
2399:
2384:
2380:
2374:
2358:
2354:
2348:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2305:
2297:
2285:
2271:
2267:
2263:
2262:
2254:
2252:
2250:
2234:
2230:
2224:
2222:
2213:
2209:
2203:
2201:
2192:
2188:
2182:
2174:
2170:
2165:
2160:
2155:
2150:
2146:
2142:
2138:
2131:
2123:
2119:
2115:
2111:
2107:
2103:
2099:
2095:
2088:
2080:
2076:
2071:
2066:
2062:
2058:
2054:
2050:
2046:
2039:
2031:
2027:
2022:
2017:
2014:(7): 1572–3.
2013:
2009:
2005:
1998:
1990:
1986:
1981:
1976:
1972:
1968:
1964:
1957:
1949:
1945:
1940:
1935:
1931:
1927:
1923:
1919:
1915:
1908:
1900:
1894:
1879:
1875:
1869:
1867:
1865:
1856:
1852:
1847:
1842:
1838:
1834:
1830:
1826:
1822:
1815:
1813:
1804:
1800:
1795:
1790:
1785:
1780:
1776:
1772:
1769:(4): 1095–9.
1768:
1764:
1760:
1753:
1745:
1741:
1735:
1727:
1723:
1717:
1710:
1706:
1701:
1699:
1697:
1689:
1685:
1680:
1678:
1676:
1671:
1661:
1658:
1656:
1653:
1652:
1646:
1644:
1640:
1636:
1626:
1624:
1620:
1610:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1563:
1560:
1556:
1547:
1544:
1540:
1531:
1529:
1528:glioblastomas
1519:
1517:
1513:
1509:
1507:
1503:
1500:
1496:
1486:
1484:
1480:
1470:
1467:
1466:bone length.
1464:
1459:
1457:
1453:
1442:
1440:
1436:
1432:
1428:
1423:
1421:
1417:
1413:
1409:
1405:
1401:
1397:
1387:
1385:
1381:
1377:
1373:
1368:
1366:
1362:
1358:
1354:
1351:
1347:
1343:
1339:
1327:
1322:
1318:
1314:
1311:
1307:
1300:
1298:
1295:
1291:
1287:
1283:
1280:
1276:
1272:
1265:
1259:
1255:
1252:
1246:
1244:
1240:
1236:
1232:
1228:
1222:
1218:
1215:
1211:
1204:
1202:
1198:
1192:
1188:
1184:
1180:
1176:
1172:
1168:
1165:
1159:
1157:
1153:
1149:
1145:
1141:
1135:
1131:
1128:
1126:RefSeq (mRNA)
1124:
1117:
1116:
1111:
1107:
1104:
1098:
1097:
1092:
1088:
1085:
1083:
1079:
1072:
1071:
1066:
1062:
1059:
1053:
1052:
1047:
1043:
1040:
1038:
1034:
1027:
1026:
1021:
1017:
1014:
1008:
1007:
1002:
998:
995:
993:
989:
986:
983:
981:
978:
974:
971:
967:
963:
956:
952:
947:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
787:
785:
782:
781:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
706:
704:
701:
700:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
611:
610:Gene ontology
607:
603:
591:
586:
582:
575:
570:
567:
565:
561:
553:
548:
537:
534:hair follicle
533:
529:
525:
521:
517:
513:
509:
505:
501:
500:
497:
493:
488:
485:
475:
471:
467:
463:
459:
455:
451:
447:
443:
440:skin of thigh
439:
438:
435:
431:
426:
423:
422:
419:
417:
413:
411:
410:
406:
405:
402:
400:
396:
392:
388:
384:
376:
371:
367:
363:
358:
348:
344:
337:
330:
324:
317:
309:
305:
301:
296:
292:
287:
283:
275:
270:
266:
262:
257:
247:
243:
236:
229:
223:
216:
212:
206:
202:
198:
193:
189:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
132:
127:
120:
115:
110:
99:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
9554:Cerebrolysin
9550:
9524:Pleiotrophin
9480:Interleukins
9393:
9374:
9344:
9263:Fruquintinib
9253:Cabozantinib
9234:
9224:
9182:
9146:Lestaurtinib
9097:
9077:
9045:Lestaurtinib
8996:
8986:
8967:Antagonists:
8966:
8900:Deoxygedunin
8855:3,7,8,2'-THF
8846:
8825:
8816:Against NGF:
8815:
8812:
8768:Against NGF:
8767:
8760:
8757:
8720:Lestaurtinib
8671:
8661:
8655:Testosterone
8637:Antagonists:
8636:
8586:
8486:
8471:
8446:
8427:
8417:
8396:
8386:
8365:
8355:
8334:
8319:
8279:
8194:
8162:
8141:
8132:Against NGF:
8131:
8128:
8084:Against NGF:
8083:
8080:
8074:Testosterone
8056:Antagonists:
8055:
8005:
7975:
7936:
7911:
7900:
7877:Teprotumumab
7838:
7808:
7767:
7716:Ficlatuzumab
7711:Emibetuzumab
7707:
7661:JNJ-38877605
7631:Cabozantinib
7602:
7592:
7581:Fosgonimeton
7576:
7551:
7493:
7471:
7412:
7404:
7395:Infigratinib
7391:
7376:
7279:
7196:
7130:Betacellulin
7126:
7109:Seribantumab
7095:
7072:
7031:
6996:
6990:Unknown/none
6989:
6985:
6919:
6844:
6803:Betacellulin
6798:Amphiregulin
6793:
6785:(ErbB1/HER1)
6749:
6721:
6701:
6687:Antagonists:
6686:
6671:
6664:Angiopoietin
6605:Translocases
6602:
6589:
6576:
6563:
6550:
6540:Transferases
6537:
6524:
6381:Binding site
6227:SRC-B family
6196:SRC-A family
5953:RET receptor
5924:AXL receptor
5846:RYK receptor
5803:DDR receptor
5779:ROR receptor
5755:TIE receptor
5731:LTK receptor
5642:EPH receptor
5609:Trk receptor
5585:HGF receptor
5540:
5522:FGF receptor
5280:
4857:
4777:
4755:
4733:
4580:
4543:
4506:
4459:
4429:
4402:
4224:
4130:
3978:
3707:
3459:
3109:
3085:
2907:
2847:
2846:
2834:
2749:
2745:
2714:
2710:
2679:
2675:
2641:(4): 381–5.
2638:
2634:
2612:(1): 75–91.
2609:
2605:
2569:
2565:
2523:
2519:
2479:
2475:
2451:
2412:
2408:
2398:
2386:. Retrieved
2382:
2373:
2361:. Retrieved
2356:
2347:
2317:(8): 690–7.
2314:
2310:
2304:
2273:. Retrieved
2260:
2236:. Retrieved
2232:
2211:
2208:"FGFR3 gene"
2190:
2181:
2144:
2140:
2130:
2097:
2093:
2087:
2052:
2048:
2038:
2011:
2007:
1997:
1970:
1966:
1956:
1924:(1): 29–41.
1921:
1917:
1907:
1893:
1882:. Retrieved
1877:
1874:"FGFR3 gene"
1831:(2): 45–50.
1828:
1824:
1766:
1762:
1752:
1743:
1734:
1725:
1716:
1632:
1629:Interactions
1616:
1591:hearing loss
1569:
1553:
1537:
1525:
1522:Glioblastoma
1518:antibodies.
1510:
1492:
1476:
1468:
1460:
1448:
1431:ossification
1424:
1393:
1369:
1365:chromosome 4
1356:
1349:
1341:
1337:
1336:
1261:
1243:NP_001341739
1239:NP_001341738
1231:NP_001156685
1224:
1201:NM_001359037
1197:NM_001359036
1194:
1183:NM_001205270
1179:NM_001163217
1175:NM_001163216
1171:NM_001163215
1156:NM_001354810
1152:NM_001354809
1144:NM_001163213
1137:
1113:
1094:
1068:
1049:
1023:
1004:
984:
979:
835:MAPK cascade
754:cell surface
414:
407:
134:External IDs
85:
29:
9514:Oncomodulin
9378:Aflibercept
9368:Ranibizumab
9363:Ramucirumab
9353:Bevacizumab
9345:Antibodies:
9303:Regorafenib
9243:Altiratinib
9156:ONO-5390556
9126:Entrectinib
9101:Altiratinib
9055:ONO-5390556
9025:Entrectinib
9000:Altiratinib
8786:Frunevetmab
8758:Antibodies:
8735:ONO-5390556
8700:Entrectinib
8675:Altiratinib
8630:Tavilermide
8525:Quizartinib
8464:SCF (c-Kit)
8288:Ramucirumab
8280:Antibodies:
8253:Quizartinib
8203:Avapritinib
8166:Becaplermin
8102:Frunevetmab
8081:Antibodies:
7984:Trofinetide
7915:Dusigitumab
7912:Antibodies:
7867:Robatumumab
7857:Figitumumab
7852:Dalotuzumab
7847:Cixutumumab
7839:Antibodies:
7731:Rilotumumab
7726:Onartuzumab
7721:Flanvotumab
7708:Antibodies:
7676:PF-04217903
7606:Altiratinib
7569:HGF (c-Met)
7472:Antibodies:
7377:Antibodies:
7099:Duligotumab
7096:Antibodies:
7010:Trastuzumab
7000:Ertumaxomab
6997:Antibodies:
6968:Zalutumumab
6963:Panitumumab
6958:Nimotuzumab
6953:Necitumumab
6943:Imgatuzumab
6920:Antibodies:
6903:Osimertinib
6868:Dacomitinib
6763:Dapiclermin
6722:Antibodies:
6705:Altiratinib
6376:Active site
3287:Somatomedin
3156:Somatomedin
2999:TGF pathway
2890:PDB gallery
2292:|work=
1412:hydrophobic
1376:chondrocyte
663:ATP binding
472:optic nerve
448:skin of arm
444:skin of hip
373:33,894,412
360:33,879,018
112:Identifiers
9592:Categories
9333:Vandetanib
9298:Rebastinib
9293:Pegaptanib
9283:Nintedanib
9273:Lenvatinib
9238:Agerafenib
9191:Ripretinib
9116:CH-7057288
9015:CH-7057288
8880:7,8,3'-THF
8875:7,8,2'-THF
8801:Ranevetmab
8791:Fulranumab
8745:Rebastinib
8690:CH-7057288
8605:Cenegermin
8490:Agerafenib
8450:Agerafenib
8431:Vandetanib
8400:Vandetanib
8369:Vandetanib
8338:Vandetanib
8283:Olaratumab
8258:Ripretinib
8238:Nintedanib
8223:Lenvatinib
8213:Crenolanib
8198:Agerafenib
8117:Ranevetmab
8107:Fulranumab
8024:Cenegermin
7998:LNGF (p75)
7920:Xentuzumab
7882:Xentuzumab
7827:NVP-AEW541
7822:NVP-ADW742
7817:Linsitinib
7812:BMS-754807
7797:Mecasermin
7696:Tivantinib
7686:PHA-665752
7681:PF-2341066
7651:Golvatinib
7641:Crizotinib
7636:Capmatinib
7626:BMS-777607
7621:Amuvatinib
7497:Ersofermin
7460:Sprifermin
7416:Ersofermin
7365:Sprifermin
7355:Repifermin
7350:Palifermin
7283:Ersofermin
7262:Velafermin
7247:Repifermin
7200:Ersofermin
7119:ErbB4/HER4
7104:Patritumab
7065:ErbB3/HER3
7045:Mubritinib
7005:Pertuzumab
6978:ErbB2/HER2
6908:Vandetanib
6863:Canertinib
6858:Brigatinib
6853:Agerafenib
6833:Nepidermin
6828:Murodermin
6818:Epiregulin
6773:EGF (ErbB)
6731:Nesvacumab
6725:Evinacumab
6715:Rebastinib
6656:modulators
6579:Isomerases
6553:Hydrolases
6420:Regulation
3342:(see also
2566:Cell Cycle
2275:2018-11-17
2147:(1): 186.
1884:2018-09-27
1711:, May 2017
1690:, May 2017
1666:References
1587:strabismus
1497:and FGFR3–
1400:amino acid
418:(ortholog)
272:1,808,872
259:1,793,293
155:HomoloGene
9358:Icrucumab
9338:WHI-P 154
9328:Tivozanib
9323:Toceranib
9318:Sunitinib
9313:Sorafenib
9308:Semaxanib
9288:Pazopanib
9278:Motesanib
9268:Lapatinib
9258:Cediranib
9196:Telbermin
9183:Agonists:
9131:GZ-389988
9111:CE-245677
9078:Agonists:
9030:GZ-389988
9010:CE-245677
8910:Diosmetin
8847:Agonists:
8813:Aptamers:
8806:Tanezumab
8781:Fasinumab
8725:Milciclib
8705:GZ-389988
8685:CE-245677
8587:Agonists:
8540:Toceranib
8535:Sunitinib
8530:Sorafenib
8520:Pazopanib
8515:Nilotinib
8510:Masitinib
8500:Dasatinib
8472:Agonists:
8418:Agonists:
8387:Agonists:
8356:Agonists:
8328:Liatermin
8320:Agonists:
8303:RET (GFL)
8293:Tovetumab
8273:Toceranib
8268:Sorafenib
8263:Sunitinib
8248:Radotinib
8243:Pazopanib
8233:Motesanib
8228:Masitinib
8163:Agonists:
8129:Aptamers:
8122:Tanezumab
8097:Fasinumab
8006:Agonists:
7862:Ganitumab
7782:IGF-1 LR3
7701:Volitinib
7656:INCB28060
7646:Foretinib
7552:Agonists:
7536:Trafermin
7494:Agonists:
7475:Burosumab
7465:Trafermin
7413:Agonists:
7380:Aprutumab
7370:Trafermin
7332:10 (KGF2)
7280:Agonists:
7257:Trafermin
7237:10 (KGF2)
7197:Agonists:
7127:Agonists:
7073:Agonists:
7055:Tucatinib
7050:Neratinib
7040:Lapatinib
6948:Matuzumab
6938:Futuximab
6923:Cetuximab
6913:WHI-P 154
6898:Neratinib
6893:Lapatinib
6883:Grandinin
6878:Gefitinib
6873:Erlotinib
6750:Agonists:
6710:CE-245677
6672:Agonists:
6458:EC number
2952:Receptors
2388:March 18,
2363:March 18,
2294:ignored (
2284:cite book
1579:bilateral
1445:Mutations
1235:NP_075254
1227:NP_000133
1187:NM_008010
1148:NM_022965
1140:NM_000142
970:Orthologs
709:cytoplasm
163:GeneCards
9540:instead)
9529:Renalase
9490:instead)
9461:instead)
9408:instead)
9248:Axitinib
9217:D (FIGF)
9161:PLX-7486
9151:ONO-4474
9106:AZD-6918
9060:PLX-7486
9050:ONO-4474
9005:AZD-6918
8987:Ligands:
8905:Deprenyl
8865:7,3'-DHF
8796:MEDI-578
8776:ASP-6294
8740:PLX-7486
8730:ONO-4474
8680:AZD-6918
8640:ALE-0540
8561:instead.
8505:Imatinib
8495:Axitinib
8475:Ancestim
8440:Unsorted
8218:Imatinib
8208:Axitinib
8112:MEDI-578
8092:ASP-6294
8059:ALE-0540
7901:Agonists
7842:AVE-1642
7768:Agonists
7691:SU-11274
7577:Agonists
7555:FGF15/19
7545:Unsorted
7510:2 (bFGF)
7429:2 (bFGF)
7296:2 (bFGF)
7213:2 (bFGF)
7035:Afatinib
6986:Agonists
6888:Icotinib
6848:Afatinib
6794:Agonists
6482:Kinetics
6406:Cofactor
6369:Activity
3336:Proteins
3003:TGF-beta
2786:14732692
2733:17255960
2698:16274647
2655:12424440
2626:11426459
2596:24626198
2542:10574949
2439:29848605
2383:Orphanet
2339:30837380
2270:20301540
2238:July 15,
2173:33168106
2122:53041768
2114:30342880
2079:27381494
2030:17568799
1989:23880303
1948:22045636
1855:25343101
1707:–
1686:–
1649:See also
1635:interact
1499:BAIAP2L1
1390:Function
1310:Wikidata
949:Sources:
724:membrane
9582:Biology
9417:Ephrins
9121:DS-6051
9020:DS-6051
8925:LM22A-4
8915:DMAQ-B1
8870:7,8-DHF
8850:3,7-DHF
8819:RBM-004
8764:GBR-900
8695:DS-6051
8665:VM-902A
8135:RBM-004
7832:OSl-906
7792:Insulin
7671:MK-2461
7616:AMG-458
6753:Axokine
6592:Ligases
6362:Enzymes
5383:2.7.10)
5144:301–350
4938:251–300
4890:CD240CE
4687:201–250
4371:151–200
4094:101–150
3020:Activin
2841:PDBe-KB
2831:UniProt
2754:Bibcode
2663:7425804
2587:4050160
2498:8576175
2430:6716598
2164:7653727
2070:5066128
1939:3240715
1846:4204580
1803:1847508
1771:Bibcode
1709:Ensembl
1688:Ensembl
1575:coronal
1372:isoform
1346:protein
1344:) is a
1082:UniProt
1037:Ensembl
976:Species
955:QuickGO
769:nucleus
393:pattern
119:Aliases
9568:Portal
9387:Others
9081:BNN-20
8970:ANA-12
8895:BNN-20
8615:DHEA-S
8600:BNN-27
8595:BNN-20
8034:DHEA-S
8019:BNN-27
8014:BNN-20
7930:Others
7135:Epigen
6813:Epigen
6566:Lyases
6300:family
6261:family
6165:family
6136:family
6112:family
6088:family
6064:family
6040:family
6016:family
5955:family
5926:family
5914:AATYK2
5902:family
5867:family
5848:family
5829:family
5805:family
5781:family
5757:family
5733:family
5644:family
5611:family
5587:family
5575:VEGFR3
5570:VEGFR2
5565:VEGFR1
5558:family
5524:family
5511:PDGFRB
5506:PDGFRA
5452:family
5151:CD300A
5110:CDw293
4895:CD240D
4756:CD213a
4734:CDw210
4699:CD202b
4673:CDw199
4668:CDw198
4322:CD140b
3754:51–100
2836:P22607
2822:(MeSH)
2784:
2777:327120
2774:
2731:
2696:
2661:
2653:
2624:
2594:
2584:
2540:
2496:
2437:
2427:
2359:. NCBI
2357:MedGen
2337:
2331:872478
2329:
2268:
2171:
2161:
2120:
2112:
2077:
2067:
2028:
1987:
1946:
1936:
1853:
1843:
1801:
1791:
1619:BGJ398
1605:, and
1593:, and
1404:ligand
1342:FGFR-3
1296:search
1294:PubMed
1115:Q61851
1096:P22607
992:Entrez
564:BioGPS
251:4p16.3
143:134934
9536:(see
9486:(see
9457:(see
9404:(see
9136:K252a
9035:K252a
8710:K252a
8650:FX007
8410:GFRα4
8379:GFRα3
8348:GFRα2
8312:GFRα1
7940:IGFBP
7893:IGF-2
7872:R1507
7760:IGF-1
7666:K252a
7486:FGFR4
7405:FGFR3
7272:FGFR2
7189:FGFR1
6518:Types
6312:ZAP70
5978:STYK1
5943:TYRO3
5909:AATYK
5716:EPHB6
5711:EPHB5
5706:EPHB4
5701:EPHB3
5696:EPHB2
5691:EPHB1
5686:EPHA8
5681:EPHA7
5676:EPHA6
5671:EPHA5
5666:EPHA4
5661:EPHA3
5656:EPHA2
5651:EPHA1
5628:NTRK3
5623:NTRK2
5618:NTRK1
5546:FGFR4
5541:FGFR3
5536:FGFR2
5531:FGFR1
5502:PDGFR
5487:CSF1R
5469:INSRR
5459:IGF1R
5440:ERBB4
5435:ERBB3
5430:ERBB2
5331:CD350
5326:CD349
5321:CD344
5316:CD340
5311:CD339
5306:CD338
5301:CD337
5296:CD336
5291:CD335
5286:CD334
5281:CD333
5276:CD332
5271:CD331
5266:CD329
5261:CD328
5256:CD327
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