424:
401:
40:
744:
As of
September 19, 2018, the price for the generic equivalent was $ 10.01 per tablet from West-ward Pharmaceuticals Corp., Edenbridge Pharmaceuticals, LLC and Oceanside Pharmaceuticals. As of July 22, 2020 the price decreased to $ 3.45 with availability from additional generic manufacturers. As of
733:
National
Average Drug Acquisition Cost data from the Centers for Medicare and Medicaid Services shows that the average price paid by retail pharmacies for an Edecrin 25 MG tablet was $ 5.24 as 11/28/13 by Bausch Health US, LLC, formerly Valeant Pharmaceuticals. The price from Bausch Health US, LLC
605:. A con with ethacrynic acid compared to the other loop diuretic drugs such as furosemide is that it has a significantly steep dose-response curve, which means the drug's dosing is very important as small variance in dose can cause a significant difference in the biological response.
707:. Loss of potassium ions is less marked but chances of hypochloremic alkalosis are greater. The dose response curve of ethacrynic acid is steeper than that of furosemide and, in general, it is less manageable; dose range is 50โ150 mg.
1540:
1351:
The
Division has uncovered price-fixing, bid-rigging, and customer-allocation schemes in one of the most important markets for the health and wallets of American consumers: the
1594:
1345:
It is known whether this apparent price fixing is actively being investigated, but the United States
Department of Justice Antitrust Division Spring Update 2021 notes:
2293:
687:) and liver damage when administered in extremely high dosages. On oral administration, it produces diarrhea; intestinal bleeding may occur at higher doses.
106:
1348:"The Division remains committed to rooting out illegal conduct that corrupts critical healthcare markets. That work is more important now than ever before.
493:
1418:
1569:
1548:
62:
2122:
1414:
1410:
507:
730:
The ethacrynic acid tablet market had U.S. sales of approximately $ 17 million for the 12 months ending April 2020 according to IQVIA.
1431:
Bosher SK (1980). "The nature of the ototoxic actions of ethacrynic acid upon the mammalian endolymph system. I. Functional aspects".
636:
when a stronger agent is required. It is available as a pill or injected form. The pill is used to treat edema associated with
2288:
2219:
1693:
700:
612:
and may thus be used in individuals with sulfa allergies in whom the sulfonamide loop diuretics would be contraindicated.
552:
2091:
1625:
1334:
683:, which may manifest as muscle cramps or weakness. It has also been known to cause reversible or permanent hearing loss (
1515:
1406:
1945:
566:
527:
2236:
2043:
745:
February 17, 2021 the average price paid by pharmacies was $ 5.69 per 25 MG tablet with 10 generic manufacturers.
2205:
2072:
676:, ethacrynic acid can cause frequent urination, but this usually resolves after taking the drug for a few weeks.
178:
136:
17:
2263:
249:
2298:
1662:
419:
300:
737:
In 2015, Valeant was involved in a number of controversies surrounding drug price hikes and the use of a
380:
1931:
1355:
industry. Indeed, nearly 90% of all prescriptions in the United States are filled with generic drugs."
574:
369:
1766:
711:
660:. The injected form is used to rapidly remove water from the body when needed โ for example in acute
2077:
1858:
1770:
653:
637:
594:
535:
InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
396:
2268:
2224:
1618:
94:
52:
2273:
1935:
1854:
1647:
609:
160:
2283:
2278:
1973:
1775:
1689:
719:
349:
240:
2003:
1327: 5.69
1316: 5.69
1305: 5.69
1294: 5.69
1283: 5.69
1272: 5.69
1261: 5.69
1250: 5.69
1239: 5.69
1228: 5.69
1217: 5.08
1206: 5.08
1195: 5.08
1184: 5.08
1173: 5.08
1162: 5.08
1151: 5.08
1140: 5.08
1129: 5.08
1118: 5.08
1107: 3.45
1096: 3.45
1085: 3.45
1074: 3.45
1063: 3.45
1052: 3.45
1041: 3.45
1030: 3.45
1019: 3.45
1008: 5.76
997: 5.76
986: 5.76
975: 5.76
964: 5.76
953: 5.76
942: 5.76
931: 5.76
920: 9.81
909: 9.81
898: 9.81
887: 9.81
876: 9.81
865: 9.81
854: 9.81
843: 9.81
309:
289:
72:
8:
1819:
1789:
195:
423:
400:
204:
2165:
1844:
1824:
1611:
1492:
1467:
738:
657:
1335:
https://data.medicaid.gov/dataset/d5eaf378-dcef-5779-83de-acdd8347d68e/data?conditions
2159:
2133:
1497:
1448:
1388:
86:
832: 10.01
821: 10.01
810: 10.01
799: 10.01
788: 10.01
777: 10.01
722:. This family of enzymes has been shown to have a high rate of genetic variability.
620:
Ethacrynic acid is a phenoxyacetic acid derivative, and contains an ฮฑ,ฮฒ-unsaturated
2035:
1834:
1804:
1487:
1479:
1440:
1380:
1371:
Somberg JC, Molnar J (January 2009). "The pleiotropic effects of ethacrynic acid".
436:
152:
119:
2081:
2039:
1666:
1384:
661:
229:
2230:
2128:
1988:
1799:
652:
associated with cancer or edema, and management of hospitalized children with
602:
31:
1444:
1337:=ndc_description&conditions =%25ethacrynic%20acid%25&conditions =like
2257:
2170:
1867:
1809:
1747:
1685:
1675:
645:
598:
582:
412:
2013:
1982:
1912:
1839:
1638:
1483:
1392:
1352:
704:
586:
114:
1570:"Valeant's price-hike strategy goes far beyond two high-profile increases"
1501:
1452:
2189:
2184:
2178:
2155:
1963:
1882:
1872:
1727:
684:
680:
80:
269:
2107:
2102:
2097:
2019:
1998:
1907:
1892:
1887:
1829:
1752:
1742:
1732:
1712:
1702:
469:
280:
2112:
1993:
1953:
1902:
1897:
1877:
1814:
1737:
1707:
641:
215:
66:
1541:"NADAC (National Average Drug Acquisition Cost) | Data.Medicaid.gov"
749:
Ethacrynic Acid 25 MG Tablet
National Average Drug Acquisition Cost
710:
Ethacrynic acid and its glutathione-adduct are potent inhibitors of
2174:
2057:
2052:
1958:
1917:
1794:
1784:
1762:
1722:
1634:
1516:"Upsher-Smith Launches Ethacrynic Acid Tablets, USP - Upsher-Smith"
673:
329:
260:
1603:
492:
2151:
649:
39:
621:
360:
1595:"Generic Drugs Investigation Targets Anticompetitive Schemes"
696:
633:
590:
483:
340:
385:
2062:
1466:
Datey KK, Deshmukh SN, Dalvi CP, Purandare NM (July 1967).
1465:
320:
664:โ or when a person cannot take the medicine in pill form.
608:
Unlike the other loop diuretics, etacrynic acid is not a
632:
Ethacrynic acid is a diuretic that is used to treat
248:
734:increased to $ 21.72 per tablet as of 5/18/2016.
2255:
228:
203:
2294:World Anti-Doping Agency prohibited substances
725:
718:family members, which are enzymes involved in
1619:
1370:
1340:
1333:Up to date price information can be found at
1468:"Hepatocellular damage with ethacrynic acid"
1364:
144:In general: โ (Prescription only)
1626:
1612:
1459:
1424:
422:
399:
288:
38:
1491:
308:
395:
268:
85:
14:
2256:
1430:
690:
615:
515:O=C(O)COc1c(Cl)c(Cl)c(cc1)C(=O)C(=C)CC
413:
1607:
1411:FDA site for NDA 016093 injected form
368:
348:
71:
1399:
118:
1633:
741:for the distribution of its drugs.
695:Ethacrynic acid acts by inhibiting
650:accumulation of liquid in the belly
328:
219:
24:
667:
25:
2310:
1415:FDA site for NDA 016092 oral form
1409:. Last updated February 2005 per
1421:, each accessed January 16, 2016
1373:American Journal of Therapeutics
1244:Edenbridge Pharmaceuticals, Llc
1222:West-ward Pharmaceuticals Corp.
1123:Edenbridge Pharmaceuticals, Llc
1112:West-ward Pharmaceuticals Corp.
1024:Edenbridge Pharmaceuticals, Llc
1013:West-ward Pharmaceuticals Corp.
936:Edenbridge Pharmaceuticals, Llc
925:West-ward Pharmaceuticals Corp.
848:Edenbridge Pharmaceuticals, Llc
837:West-ward Pharmaceuticals Corp.
782:Edenbridge Pharmaceuticals, Llc
771:West-ward Pharmaceuticals Corp.
453:
447:
2206:Hydrochlorothiazide/triamterene
2073:Vasopressin receptor inhibitors
1233:Upsher-smith Laboratories, Llc
1211:Upsher-smith Laboratories, Llc
679:Ethacrynic acid can also cause
540:Key:AVOLMBLBETYQHX-UHFFFAOYSA-N
1587:
1562:
1533:
1520:Upsher-Smith Laboratories, LLC
1508:
1321:Amneal Pharmaceuticals Ny Llc
1200:Amneal Pharmaceuticals Ny Llc
1090:Amneal Pharmaceuticals Ny Llc
1002:Amneal Pharmaceuticals Ny Llc
914:Amneal Pharmaceuticals Ny Llc
826:Amneal Pharmaceuticals Ny Llc
627:
459:
441:
13:
1:
2289:Carbonic anhydrase inhibitors
1358:
1385:10.1097/MJT.0b013e3181961264
1299:Lupin Pharmaceuticals, Inc.
1277:Sciegen Pharmaceuticals Inc
1178:Lupin Pharmaceuticals, Inc.
1156:Sciegen Pharmaceuticals Inc
1068:Lupin Pharmaceuticals, Inc.
1057:Sciegen Pharmaceuticals Inc
980:Lupin Pharmaceuticals, Inc.
969:Sciegen Pharmaceuticals Inc
892:Lupin Pharmaceuticals, Inc.
881:Sciegen Pharmaceuticals Inc
7:
726:United States price history
10:
2315:
1341:Price fixing investigation
1310:Oceanside Pharmaceuticals
1189:Oceanside Pharmaceuticals
1079:Oceanside Pharmaceuticals
991:Oceanside Pharmaceuticals
903:Oceanside Pharmaceuticals
793:Oceanside Pharmaceuticals
431:Chemical and physical data
2214:
2198:
2144:
2071:
2034:
1972:
1944:
1930:
1853:
1761:
1684:
1661:
1646:
1445:10.3109/00016488009127156
1266:Par Pharmaceutical, Inc.
1145:Par Pharmaceutical, Inc.
1046:Par Pharmaceutical, Inc.
958:Par Pharmaceutical, Inc.
870:Par Pharmaceutical, Inc.
815:Par Pharmaceutical, Inc.
548:
523:
503:
481:
468:
435:
430:
411:
379:
359:
339:
319:
299:
279:
259:
239:
214:
194:
174:
169:
159:
151:
135:
130:
105:
93:
79:
61:
51:
46:
37:
654:congenital heart disease
638:congestive heart failure
595:congestive heart failure
593:caused by diseases like
73:International Drug Names
1974:Aldosterone antagonists
1472:British Medical Journal
701:ascending loop of Henle
1484:10.1136/bmj.3.5558.152
1433:Acta Oto-Laryngologica
2264:Disulfiram-like drugs
720:xenobiotic metabolism
2299:Vinylidene compounds
2199:Combination products
2004:Potassium canrenoate
1407:Etacrynic acid Label
681:low potassium levels
2166:mercurial diuretics
1820:Hydrochlorothiazide
1790:Bendroflumethiazide
750:
691:Mechanism of action
616:Structural features
587:high blood pressure
34:
2241:Never to phase III
1845:Trichlormethiazide
1825:Hydroflumethiazide
748:
739:specialty pharmacy
658:nephrotic syndrome
30:
2251:
2250:
2134:Lithium carbonate
2036:Osmotic diuretics
2030:
2029:
1932:Potassium-sparing
1926:
1925:
1545:data.medicaid.gov
1331:
1330:
560:
559:
494:Interactive image
381:CompTox Dashboard
27:Chemical compound
16:(Redirected from
2306:
1942:
1941:
1835:Methyclothiazide
1805:Cyclopenthiazide
1659:
1658:
1628:
1621:
1614:
1605:
1604:
1599:
1598:
1597:. 10 March 2021.
1591:
1585:
1584:
1582:
1581:
1576:. 5 October 2015
1566:
1560:
1559:
1557:
1556:
1547:. Archived from
1537:
1531:
1530:
1528:
1527:
1512:
1506:
1505:
1495:
1463:
1457:
1456:
1428:
1422:
1403:
1397:
1396:
1368:
751:
747:
556:
555:
496:
476:
461:
455:
449:
443:
426:
415:
404:
403:
389:
387:
372:
352:
332:
312:
292:
272:
252:
232:
222:
221:
207:
122:
89:
75:
42:
35:
33:
29:
21:
2314:
2313:
2309:
2308:
2307:
2305:
2304:
2303:
2254:
2253:
2252:
2247:
2246:
2231:Clinical trials
2210:
2194:
2140:
2075:
2067:
2026:
1968:
1922:
1849:
1776:Calcium-sparing
1774:
1757:
1680:
1650:
1642:
1632:
1602:
1593:
1592:
1588:
1579:
1577:
1568:
1567:
1563:
1554:
1552:
1539:
1538:
1534:
1525:
1523:
1514:
1513:
1509:
1478:(5558): 152โ3.
1464:
1460:
1439:(5โ6): 407โ18.
1429:
1425:
1404:
1400:
1369:
1365:
1361:
1343:
728:
693:
670:
668:Adverse effects
662:pulmonary edema
630:
618:
571:ethacrynic acid
551:
549:
544:
541:
536:
531:
530:
519:
516:
511:
510:
499:
474:
464:
458:
452:
446:
407:
383:
375:
355:
335:
315:
295:
275:
255:
235:
218:
210:
190:
187:
182:
181:
161:Protein binding
153:Pharmacokinetic
147:
126:
96:
28:
23:
22:
18:Ethacrynic acid
15:
12:
11:
5:
2312:
2302:
2301:
2296:
2291:
2286:
2281:
2276:
2271:
2269:Loop diuretics
2266:
2249:
2248:
2245:
2244:
2243:
2242:
2239:
2228:
2222:
2216:
2215:
2212:
2211:
2209:
2208:
2202:
2200:
2196:
2195:
2193:
2192:
2187:
2182:
2162:
2148:
2146:
2142:
2141:
2139:
2138:
2137:
2136:
2131:
2129:Demeclocycline
2118:
2117:
2116:
2115:
2110:
2105:
2100:
2087:
2085:
2069:
2068:
2066:
2065:
2060:
2055:
2049:
2047:
2032:
2031:
2028:
2027:
2025:
2024:
2023:
2022:
2009:
2008:
2007:
2006:
2001:
1996:
1991:
1989:Spironolactone
1978:
1976:
1970:
1969:
1967:
1966:
1961:
1956:
1950:
1948:
1939:
1928:
1927:
1924:
1923:
1921:
1920:
1915:
1910:
1905:
1900:
1895:
1890:
1885:
1880:
1875:
1870:
1864:
1862:
1855:Thiazide-likes
1851:
1850:
1848:
1847:
1842:
1837:
1832:
1827:
1822:
1817:
1812:
1807:
1802:
1800:Chlorothiazide
1797:
1792:
1787:
1781:
1779:
1759:
1758:
1756:
1755:
1750:
1745:
1740:
1735:
1730:
1725:
1720:
1718:Etacrynic acid
1715:
1710:
1705:
1699:
1697:
1682:
1681:
1679:
1678:
1672:
1670:
1656:
1653:etacrynic acid
1644:
1643:
1631:
1630:
1623:
1616:
1608:
1601:
1600:
1586:
1561:
1532:
1507:
1458:
1423:
1405:Merck and FDA
1398:
1362:
1360:
1357:
1342:
1339:
1329:
1328:
1325:
1322:
1318:
1317:
1314:
1311:
1307:
1306:
1303:
1300:
1296:
1295:
1292:
1289:
1288:Trupharma Llc
1285:
1284:
1281:
1278:
1274:
1273:
1270:
1267:
1263:
1262:
1259:
1256:
1255:Alvogen, Inc.
1252:
1251:
1248:
1245:
1241:
1240:
1237:
1234:
1230:
1229:
1226:
1223:
1219:
1218:
1215:
1212:
1208:
1207:
1204:
1201:
1197:
1196:
1193:
1190:
1186:
1185:
1182:
1179:
1175:
1174:
1171:
1168:
1167:Trupharma Llc
1164:
1163:
1160:
1157:
1153:
1152:
1149:
1146:
1142:
1141:
1138:
1135:
1134:Alvogen, Inc.
1131:
1130:
1127:
1124:
1120:
1119:
1116:
1113:
1109:
1108:
1105:
1102:
1101:Trupharma Llc
1098:
1097:
1094:
1091:
1087:
1086:
1083:
1080:
1076:
1075:
1072:
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1065:
1064:
1061:
1058:
1054:
1053:
1050:
1047:
1043:
1042:
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1036:
1035:Alvogen, Inc.
1032:
1031:
1028:
1025:
1021:
1020:
1017:
1014:
1010:
1009:
1006:
1003:
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995:
992:
988:
987:
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981:
977:
976:
973:
970:
966:
965:
962:
959:
955:
954:
951:
948:
947:Alvogen, Inc.
944:
943:
940:
937:
933:
932:
929:
926:
922:
921:
918:
915:
911:
910:
907:
904:
900:
899:
896:
893:
889:
888:
885:
882:
878:
877:
874:
871:
867:
866:
863:
860:
859:Alvogen, Inc.
856:
855:
852:
849:
845:
844:
841:
838:
834:
833:
830:
827:
823:
822:
819:
816:
812:
811:
808:
805:
804:Alvogen, Inc.
801:
800:
797:
794:
790:
789:
786:
783:
779:
778:
775:
772:
768:
767:
765:NADAC_Per_Unit
762:
760:Effective_Date
757:
727:
724:
692:
689:
669:
666:
629:
626:
617:
614:
603:kidney failure
585:used to treat
577:), trade name
563:Etacrynic acid
558:
557:
546:
545:
543:
542:
539:
537:
534:
526:
525:
524:
521:
520:
518:
517:
514:
506:
505:
504:
501:
500:
498:
497:
489:
487:
479:
478:
472:
466:
465:
462:
456:
450:
444:
439:
433:
432:
428:
427:
417:
409:
408:
406:
405:
392:
390:
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376:
374:
373:
365:
363:
357:
356:
354:
353:
345:
343:
337:
336:
334:
333:
325:
323:
317:
316:
314:
313:
305:
303:
297:
296:
294:
293:
285:
283:
277:
276:
274:
273:
265:
263:
257:
256:
254:
253:
245:
243:
237:
236:
234:
233:
225:
223:
212:
211:
209:
208:
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191:
189:
188:
185:
177:
176:
175:
172:
171:
167:
166:
163:
157:
156:
149:
148:
146:
145:
141:
139:
133:
132:
128:
127:
125:
124:
111:
109:
103:
102:
99:
97:administration
91:
90:
83:
77:
76:
69:
59:
58:
55:
49:
48:
44:
43:
32:Etacrynic acid
26:
9:
6:
4:
3:
2:
2311:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2275:
2274:Piceol ethers
2272:
2270:
2267:
2265:
2262:
2261:
2259:
2240:
2238:
2235:
2234:
2232:
2229:
2226:
2223:
2221:
2218:
2217:
2213:
2207:
2204:
2203:
2201:
2197:
2191:
2188:
2186:
2183:
2180:
2176:
2172:
2171:Chlormerodrin
2168:
2167:
2163:
2161:
2157:
2153:
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2015:
2011:
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2005:
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1995:
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1983:Spirolactones
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708:
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699:in the thick
698:
688:
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682:
677:
675:
665:
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659:
655:
651:
647:
646:renal disease
643:
639:
635:
625:
623:
613:
611:
606:
604:
600:
599:liver failure
596:
592:
588:
584:
583:loop diuretic
580:
576:
572:
568:
564:
554:
547:
538:
533:
532:
529:
522:
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473:
471:
467:
440:
438:
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429:
425:
421:
418:
416:
414:ECHA InfoCard
410:
402:
398:
397:DTXSID3025257
394:
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382:
378:
371:
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56:
54:
50:
47:Clinical data
45:
41:
36:
19:
2284:Chloroarenes
2279:Acetic acids
2164:
2121:
2090:
2014:Nonsteroidal
2012:
1981:
1946:ESC blockers
1913:Quinethazone
1840:Polythiazide
1717:
1652:
1648:Sulfonamides
1589:
1578:. Retrieved
1574:FiercePharma
1573:
1564:
1553:. Retrieved
1549:the original
1544:
1535:
1524:. Retrieved
1522:. 2020-06-23
1519:
1510:
1475:
1471:
1461:
1436:
1432:
1426:
1401:
1379:(1): 102โ4.
1376:
1372:
1366:
1353:generic drug
1350:
1347:
1344:
1332:
764:
759:
755:Company Name
754:
743:
736:
732:
729:
716:-transferase
713:
712:glutathione
709:
705:macula densa
694:
678:
671:
631:
622:ketone group
619:
607:
578:
570:
562:
561:
550:
137:Legal status
131:Legal status
2227:from market
2190:Cicletanine
2185:Theobromine
2179:Meralluride
2156:Isopropanol
1964:Triamterene
1883:Clorexolone
1873:Clofenamide
1857:(primarily
1728:Indacrinone
818:11/14/2018
807:10/10/2018
685:ototoxicity
628:Medical use
610:sulfonamide
477: gยทmol
420:100.000.349
186:acetic acid
170:Identifiers
81:MedlinePlus
53:Trade names
2258:Categories
2108:Satavaptan
2103:Mozavaptan
2098:Conivaptan
2020:Finerenone
1999:Eplerenone
1908:Metolazone
1893:Indapamide
1888:Fenquizone
1830:Mebutizide
1753:Torasemide
1743:Piretanide
1733:Muzolimine
1713:Bumetanide
1703:Furosemide
1580:2021-03-14
1555:2021-03-14
1526:2021-03-14
1417:per index
1359:References
1324:2/17/2021
1313:2/17/2021
1302:2/17/2021
1291:2/17/2021
1280:2/17/2021
1269:2/17/2021
1258:2/17/2021
1247:2/17/2021
1236:2/17/2021
1225:2/17/2021
1214:9/16/2020
1203:8/19/2020
1192:8/19/2020
1181:8/19/2020
1170:8/19/2020
1159:8/19/2020
1148:8/19/2020
1137:8/19/2020
1126:8/19/2020
1115:8/19/2020
1104:7/29/2020
1093:7/22/2020
1082:7/22/2020
1071:7/22/2020
1060:7/22/2020
1049:7/22/2020
1038:7/22/2020
1027:7/22/2020
1016:7/22/2020
1005:5/20/2020
994:5/20/2020
983:5/20/2020
972:5/20/2020
961:5/20/2020
950:5/20/2020
939:5/20/2020
928:5/20/2020
917:4/22/2020
906:4/22/2020
895:4/22/2020
884:4/22/2020
873:4/22/2020
862:4/22/2020
851:4/22/2020
840:4/22/2020
829:2/27/2019
796:9/19/2018
785:9/19/2018
774:9/19/2018
482:3D model (
470:Molar mass
350:CHEBI:4876
310:M5DP350VZV
281:ChemSpider
241:IUPHAR/BPS
196:CAS Number
179:IUPAC name
2237:Phase III
2225:Withdrawn
2113:Tolvaptan
1994:Canrenone
1954:Amiloride
1903:Meticrane
1898:Mefruside
1878:Clopamide
1815:Epitizide
1763:Thiazides
1738:Ozolinone
1708:Azosemide
1635:Diuretics
642:cirrhosis
370:ChEMBL456
95:Routes of
67:Drugs.com
2175:Mersalyl
2058:Glycerol
2053:Mannitol
1959:Benzamil
1918:Xipamide
1795:Butizide
1785:Altizide
1723:Etozolin
1393:19142157
703:and the
674:diuretic
591:swelling
589:and the
553:(verify)
261:DrugBank
165:> 98%
107:ATC code
101:Oral, IV
2152:Ethanol
2092:Vaptans
1690:Na-K-Cl
1502:6028103
1493:1842848
1453:7446061
581:, is a
579:Edecrin
437:Formula
270:DB00903
216:PubChem
205:58-54-8
123:)
117: (
115:C03CC01
87:a682857
57:Edecrin
2220:WHO-EM
2123:Others
1500:
1490:
1451:
1391:
601:, and
508:SMILES
475:303.14
361:ChEMBL
330:D00313
2145:Other
1767:Na-Cl
1651:(and
697:NKCC2
672:As a
634:edema
569:) or
528:InChI
484:JSmol
341:ChEBI
2160:2M2B
2080:and
2063:Urea
1934:(at
1686:Loop
1665:(at
1498:PMID
1449:PMID
1419:here
1413:and
1389:PMID
644:and
575:USAN
321:KEGG
301:UNII
290:3163
250:7179
230:3278
155:data
63:AHFS
2078:DCT
1859:DCT
1771:DCT
1769:at
1692:at
1639:C03
1488:PMC
1480:doi
1441:doi
1381:doi
656:or
567:INN
386:EPA
220:CID
120:WHO
2260::
2233::
2177:,
2173:,
2158:,
2154:,
2082:CD
2044:DL
2042:,
2040:PT
1936:CD
1694:AL
1667:PT
1572:.
1543:.
1518:.
1496:.
1486:.
1474:.
1470:.
1447:.
1437:89
1435:.
1387:.
1377:16
1375:.
648:,
640:,
624:.
597:,
454:Cl
451:12
445:13
2181:)
2169:(
2084:)
2076:(
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2038:(
1938:)
1861:)
1778:)
1773:,
1765:(
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1688:(
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1529:.
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1395:.
1383::
714:S
573:(
565:(
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463:4
460:O
457:2
448:H
442:C
388:)
384:(
65:/
20:)
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