Knowledge

Etacrynic acid

Source ๐Ÿ“

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As of September 19, 2018, the price for the generic equivalent was $ 10.01 per tablet from West-ward Pharmaceuticals Corp., Edenbridge Pharmaceuticals, LLC and Oceanside Pharmaceuticals. As of July 22, 2020 the price decreased to $ 3.45 with availability from additional generic manufacturers. As of
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National Average Drug Acquisition Cost data from the Centers for Medicare and Medicaid Services shows that the average price paid by retail pharmacies for an Edecrin 25 MG tablet was $ 5.24 as 11/28/13 by Bausch Health US, LLC, formerly Valeant Pharmaceuticals. The price from Bausch Health US, LLC
605:. A con with ethacrynic acid compared to the other loop diuretic drugs such as furosemide is that it has a significantly steep dose-response curve, which means the drug's dosing is very important as small variance in dose can cause a significant difference in the biological response. 707:. Loss of potassium ions is less marked but chances of hypochloremic alkalosis are greater. The dose response curve of ethacrynic acid is steeper than that of furosemide and, in general, it is less manageable; dose range is 50โ€“150 mg. 1540: 1351:
The Division has uncovered price-fixing, bid-rigging, and customer-allocation schemes in one of the most important markets for the health and wallets of American consumers: the
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It is known whether this apparent price fixing is actively being investigated, but the United States Department of Justice Antitrust Division Spring Update 2021 notes:
2293: 687:) and liver damage when administered in extremely high dosages. On oral administration, it produces diarrhea; intestinal bleeding may occur at higher doses. 106: 1348:"The Division remains committed to rooting out illegal conduct that corrupts critical healthcare markets. That work is more important now than ever before. 493: 1418: 1569: 1548: 62: 2122: 1414: 1410: 507: 730:
The ethacrynic acid tablet market had U.S. sales of approximately $ 17 million for the 12 months ending April 2020 according to IQVIA.
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Bosher SK (1980). "The nature of the ototoxic actions of ethacrynic acid upon the mammalian endolymph system. I. Functional aspects".
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when a stronger agent is required. It is available as a pill or injected form. The pill is used to treat edema associated with
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and may thus be used in individuals with sulfa allergies in whom the sulfonamide loop diuretics would be contraindicated.
552: 2091: 1625: 1334: 683:, which may manifest as muscle cramps or weakness. It has also been known to cause reversible or permanent hearing loss ( 1515: 1406: 1945: 566: 527: 2236: 2043: 745:
February 17, 2021 the average price paid by pharmacies was $ 5.69 per 25 MG tablet with 10 generic manufacturers.
2205: 2072: 676:, ethacrynic acid can cause frequent urination, but this usually resolves after taking the drug for a few weeks. 178: 136: 17: 2263: 249: 2298: 1662: 419: 300: 737:
In 2015, Valeant was involved in a number of controversies surrounding drug price hikes and the use of a
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industry. Indeed, nearly 90% of all prescriptions in the United States are filled with generic drugs."
574: 369: 1766: 711: 660:. The injected form is used to rapidly remove water from the body when needed โ€“ for example in acute 2077: 1858: 1770: 653: 637: 594: 535:
InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
396: 2268: 2224: 1618: 94: 52: 2273: 1935: 1854: 1647: 609: 160: 2283: 2278: 1973: 1775: 1689: 719: 349: 240: 2003: 1327:                        5.69 1316:                        5.69 1305:                        5.69 1294:                        5.69 1283:                        5.69 1272:                        5.69 1261:                        5.69 1250:                        5.69 1239:                        5.69 1228:                        5.69 1217:                        5.08 1206:                        5.08 1195:                        5.08 1184:                        5.08 1173:                        5.08 1162:                        5.08 1151:                        5.08 1140:                        5.08 1129:                        5.08 1118:                        5.08 1107:                        3.45 1096:                        3.45 1085:                        3.45 1074:                        3.45 1063:                        3.45 1052:                        3.45 1041:                        3.45 1030:                        3.45 1019:                        3.45 1008:                        5.76 997:                        5.76 986:                        5.76 975:                        5.76 964:                        5.76 953:                        5.76 942:                        5.76 931:                        5.76 920:                        9.81 909:                        9.81 898:                        9.81 887:                        9.81 876:                        9.81 865:                        9.81 854:                        9.81 843:                        9.81 309: 289: 72: 8: 1819: 1789: 195: 423: 400: 204: 2165: 1844: 1824: 1611: 1492: 1467: 738: 657: 1335:
https://data.medicaid.gov/dataset/d5eaf378-dcef-5779-83de-acdd8347d68e/data?conditions
2159: 2133: 1497: 1448: 1388: 86: 832:                      10.01 821:                      10.01 810:                      10.01 799:                      10.01 788:                      10.01 777:                      10.01 722:. This family of enzymes has been shown to have a high rate of genetic variability. 620:
Ethacrynic acid is a phenoxyacetic acid derivative, and contains an ฮฑ,ฮฒ-unsaturated
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Somberg JC, Molnar J (January 2009). "The pleiotropic effects of ethacrynic acid".
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associated with cancer or edema, and management of hospitalized children with
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Ethacrynic Acid 25 MG Tablet National Average Drug Acquisition Cost
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Ethacrynic acid and its glutathione-adduct are potent inhibitors of
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Datey KK, Deshmukh SN, Dalvi CP, Purandare NM (July 1967).
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Unlike the other loop diuretics, etacrynic acid is not a
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Ethacrynic acid is a diuretic that is used to treat
248: 734:increased to $ 21.72 per tablet as of 5/18/2016. 2255: 228: 203: 2294:World Anti-Doping Agency prohibited substances 725: 718:family members, which are enzymes involved in 1619: 1370: 1340: 1333:Up to date price information can be found at 1468:"Hepatocellular damage with ethacrynic acid" 1364: 144:In general: โ„ž (Prescription only) 1626: 1612: 1459: 1424: 422: 399: 288: 38: 1491: 308: 395: 268: 85: 14: 2256: 1430: 690: 615: 515:O=C(O)COc1c(Cl)c(Cl)c(cc1)C(=O)C(=C)CC 413: 1607: 1411:FDA site for NDA 016093 injected form 368: 348: 71: 1399: 118: 1633: 741:for the distribution of its drugs. 695:Ethacrynic acid acts by inhibiting 650:accumulation of liquid in the belly 328: 219: 24: 667: 25: 2310: 1415:FDA site for NDA 016092 oral form 1409:. Last updated February 2005 per 1421:, each accessed January 16, 2016 1373:American Journal of Therapeutics 1244:Edenbridge Pharmaceuticals, Llc 1222:West-ward Pharmaceuticals Corp. 1123:Edenbridge Pharmaceuticals, Llc 1112:West-ward Pharmaceuticals Corp. 1024:Edenbridge Pharmaceuticals, Llc 1013:West-ward Pharmaceuticals Corp. 936:Edenbridge Pharmaceuticals, Llc 925:West-ward Pharmaceuticals Corp. 848:Edenbridge Pharmaceuticals, Llc 837:West-ward Pharmaceuticals Corp. 782:Edenbridge Pharmaceuticals, Llc 771:West-ward Pharmaceuticals Corp. 453: 447: 2206:Hydrochlorothiazide/triamterene 2073:Vasopressin receptor inhibitors 1233:Upsher-smith Laboratories, Llc 1211:Upsher-smith Laboratories, Llc 679:Ethacrynic acid can also cause 540:Key:AVOLMBLBETYQHX-UHFFFAOYSA-N 1587: 1562: 1533: 1520:Upsher-Smith Laboratories, LLC 1508: 1321:Amneal Pharmaceuticals Ny Llc 1200:Amneal Pharmaceuticals Ny Llc 1090:Amneal Pharmaceuticals Ny Llc 1002:Amneal Pharmaceuticals Ny Llc 914:Amneal Pharmaceuticals Ny Llc 826:Amneal Pharmaceuticals Ny Llc 627: 459: 441: 13: 1: 2289:Carbonic anhydrase inhibitors 1358: 1385:10.1097/MJT.0b013e3181961264 1299:Lupin Pharmaceuticals, Inc. 1277:Sciegen Pharmaceuticals Inc 1178:Lupin Pharmaceuticals, Inc. 1156:Sciegen Pharmaceuticals Inc 1068:Lupin Pharmaceuticals, Inc. 1057:Sciegen Pharmaceuticals Inc 980:Lupin Pharmaceuticals, Inc. 969:Sciegen Pharmaceuticals Inc 892:Lupin Pharmaceuticals, Inc. 881:Sciegen Pharmaceuticals Inc 7: 726:United States price history 10: 2315: 1341:Price fixing investigation 1310:Oceanside Pharmaceuticals 1189:Oceanside Pharmaceuticals 1079:Oceanside Pharmaceuticals 991:Oceanside Pharmaceuticals 903:Oceanside Pharmaceuticals 793:Oceanside Pharmaceuticals 431:Chemical and physical data 2214: 2198: 2144: 2071: 2034: 1972: 1944: 1930: 1853: 1761: 1684: 1661: 1646: 1445:10.3109/00016488009127156 1266:Par Pharmaceutical, Inc. 1145:Par Pharmaceutical, Inc. 1046:Par Pharmaceutical, Inc. 958:Par Pharmaceutical, Inc. 870:Par Pharmaceutical, Inc. 815:Par Pharmaceutical, Inc. 548: 523: 503: 481: 468: 435: 430: 411: 379: 359: 339: 319: 299: 279: 259: 239: 214: 194: 174: 169: 159: 151: 135: 130: 105: 93: 79: 61: 51: 46: 37: 654:congenital heart disease 638:congestive heart failure 595:congestive heart failure 593:caused by diseases like 73:International Drug Names 1974:Aldosterone antagonists 1472:British Medical Journal 701:ascending loop of Henle 1484:10.1136/bmj.3.5558.152 1433:Acta Oto-Laryngologica 2264:Disulfiram-like drugs 720:xenobiotic metabolism 2299:Vinylidene compounds 2199:Combination products 2004:Potassium canrenoate 1407:Etacrynic acid Label 681:low potassium levels 2166:mercurial diuretics 1820:Hydrochlorothiazide 1790:Bendroflumethiazide 750: 691:Mechanism of action 616:Structural features 587:high blood pressure 34: 2241:Never to phase III 1845:Trichlormethiazide 1825:Hydroflumethiazide 748: 739:specialty pharmacy 658:nephrotic syndrome 30: 2251: 2250: 2134:Lithium carbonate 2036:Osmotic diuretics 2030: 2029: 1932:Potassium-sparing 1926: 1925: 1545:data.medicaid.gov 1331: 1330: 560: 559: 494:Interactive image 381:CompTox Dashboard 27:Chemical compound 16:(Redirected from 2306: 1942: 1941: 1835:Methyclothiazide 1805:Cyclopenthiazide 1659: 1658: 1628: 1621: 1614: 1605: 1604: 1599: 1598: 1597:. 10 March 2021. 1591: 1585: 1584: 1582: 1581: 1576:. 5 October 2015 1566: 1560: 1559: 1557: 1556: 1547:. 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414:ECHA InfoCard 410: 402: 398: 397:DTXSID3025257 394: 393: 391: 382: 378: 371: 367: 366: 364: 362: 358: 351: 347: 346: 344: 342: 338: 331: 327: 326: 324: 322: 318: 311: 307: 306: 304: 302: 298: 291: 287: 286: 284: 282: 278: 271: 267: 266: 264: 262: 258: 251: 247: 246: 244: 242: 238: 231: 227: 226: 224: 217: 213: 206: 202: 201: 199: 197: 193: 184: 183: 180: 173: 168: 164: 162: 158: 154: 150: 143: 142: 140: 138: 134: 129: 121: 116: 113: 112: 110: 108: 104: 100: 98: 92: 88: 84: 82: 78: 74: 70: 68: 64: 60: 56: 54: 50: 47:Clinical data 45: 41: 36: 19: 2284:Chloroarenes 2279:Acetic acids 2164: 2121: 2090: 2014:Nonsteroidal 2012: 1981: 1946:ESC blockers 1913:Quinethazone 1840:Polythiazide 1717: 1652: 1648:Sulfonamides 1589: 1578:. 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Retrieved 1522:. 2020-06-23 1519: 1510: 1475: 1471: 1461: 1436: 1432: 1426: 1401: 1379:(1): 102โ€“4. 1376: 1372: 1366: 1353:generic drug 1350: 1347: 1344: 1332: 764: 759: 755:Company Name 754: 743: 736: 732: 729: 716:-transferase 713: 712:glutathione 709: 705:macula densa 694: 678: 671: 631: 622:ketone group 619: 607: 578: 570: 562: 561: 550:   137:Legal status 131:Legal status 2227:from market 2190:Cicletanine 2185:Theobromine 2179:Meralluride 2156:Isopropanol 1964:Triamterene 1883:Clorexolone 1873:Clofenamide 1857:(primarily 1728:Indacrinone 818:11/14/2018 807:10/10/2018 685:ototoxicity 628:Medical use 610:sulfonamide 477: gยทmol 420:100.000.349 186:acetic acid 170:Identifiers 81:MedlinePlus 53:Trade names 2258:Categories 2108:Satavaptan 2103:Mozavaptan 2098:Conivaptan 2020:Finerenone 1999:Eplerenone 1908:Metolazone 1893:Indapamide 1888:Fenquizone 1830:Mebutizide 1753:Torasemide 1743:Piretanide 1733:Muzolimine 1713:Bumetanide 1703:Furosemide 1580:2021-03-14 1555:2021-03-14 1526:2021-03-14 1417:per index 1359:References 1324:2/17/2021 1313:2/17/2021 1302:2/17/2021 1291:2/17/2021 1280:2/17/2021 1269:2/17/2021 1258:2/17/2021 1247:2/17/2021 1236:2/17/2021 1225:2/17/2021 1214:9/16/2020 1203:8/19/2020 1192:8/19/2020 1181:8/19/2020 1170:8/19/2020 1159:8/19/2020 1148:8/19/2020 1137:8/19/2020 1126:8/19/2020 1115:8/19/2020 1104:7/29/2020 1093:7/22/2020 1082:7/22/2020 1071:7/22/2020 1060:7/22/2020 1049:7/22/2020 1038:7/22/2020 1027:7/22/2020 1016:7/22/2020 1005:5/20/2020 994:5/20/2020 983:5/20/2020 972:5/20/2020 961:5/20/2020 950:5/20/2020 939:5/20/2020 928:5/20/2020 917:4/22/2020 906:4/22/2020 895:4/22/2020 884:4/22/2020 873:4/22/2020 862:4/22/2020 851:4/22/2020 840:4/22/2020 829:2/27/2019 796:9/19/2018 785:9/19/2018 774:9/19/2018 482:3D model ( 470:Molar mass 350:CHEBI:4876 310:M5DP350VZV 281:ChemSpider 241:IUPHAR/BPS 196:CAS Number 179:IUPAC name 2237:Phase III 2225:Withdrawn 2113:Tolvaptan 1994:Canrenone 1954:Amiloride 1903:Meticrane 1898:Mefruside 1878:Clopamide 1815:Epitizide 1763:Thiazides 1738:Ozolinone 1708:Azosemide 1635:Diuretics 642:cirrhosis 370:ChEMBL456 95:Routes of 67:Drugs.com 2175:Mersalyl 2058:Glycerol 2053:Mannitol 1959:Benzamil 1918:Xipamide 1795:Butizide 1785:Altizide 1723:Etozolin 1393:19142157 703:and the 674:diuretic 591:swelling 589:and the 553:(verify) 261:DrugBank 165:> 98% 107:ATC code 101:Oral, IV 2152:Ethanol 2092:Vaptans 1690:Na-K-Cl 1502:6028103 1493:1842848 1453:7446061 581:, is a 579:Edecrin 437:Formula 270:DB00903 216:PubChem 205:58-54-8 123:) 117: ( 115:C03CC01 87:a682857 57:Edecrin 2220:WHO-EM 2123:Others 1500:  1490:  1451:  1391:  601:, and 508:SMILES 475:303.14 361:ChEMBL 330:D00313 2145:Other 1767:Na-Cl 1651:(and 697:NKCC2 672:As a 634:edema 569:) or 528:InChI 484:JSmol 341:ChEBI 2160:2M2B 2080:and 2063:Urea 1934:(at 1686:Loop 1665:(at 1498:PMID 1449:PMID 1419:here 1413:and 1389:PMID 644:and 575:USAN 321:KEGG 301:UNII 290:3163 250:7179 230:3278 155:data 63:AHFS 2078:DCT 1859:DCT 1771:DCT 1769:at 1692:at 1639:C03 1488:PMC 1480:doi 1441:doi 1381:doi 656:or 567:INN 386:EPA 220:CID 120:WHO 2260:: 2233:: 2177:, 2173:, 2158:, 2154:, 2082:CD 2044:DL 2042:, 2040:PT 1936:CD 1694:AL 1667:PT 1572:. 1543:. 1518:. 1496:. 1486:. 1474:. 1470:. 1447:. 1437:89 1435:. 1387:. 1377:16 1375:. 648:, 640:, 624:. 597:, 454:Cl 451:12 445:13 2181:) 2169:( 2084:) 2076:( 2046:) 2038:( 1938:) 1861:) 1778:) 1773:, 1765:( 1696:) 1688:( 1669:) 1655:) 1641:) 1637:( 1627:e 1620:t 1613:v 1583:. 1558:. 1529:. 1504:. 1482:: 1476:3 1455:. 1443:: 1395:. 1383:: 714:S 573:( 565:( 486:) 463:4 460:O 457:2 448:H 442:C 388:) 384:( 65:/ 20:)

Index

Ethacrynic acid

Trade names
AHFS
Drugs.com
International Drug Names
MedlinePlus
a682857
Routes of
administration

ATC code
C03CC01
WHO
Legal status
Pharmacokinetic
Protein binding
IUPAC name
CAS Number
58-54-8
PubChem
3278
IUPHAR/BPS
7179
DrugBank
DB00903
ChemSpider
3163
UNII
M5DP350VZV
KEGG
D00313

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