1829:
315:
292:
214:
189:
566:
321:
220:
42:
3388:
1398:
1708:
2038:. There have also been a few cases of reported hearing loss and skin disorders unrelated to ODDD. Ultimately, GJA1 has low tolerance for deviations from its original sequence, with mutations resulting in loss- or gain-of-channel function that lead to disease phenotypes. It is paradoxical, however, that patients with an array of somatic mutations in
1815:
1659:
gene encoding this tail is highly conserved, indicating that it is either resistant to mutations or becomes lethal when mutated. Meanwhile, the N-terminal domain is involved in channel gating and oligomerization and, thus, may control the switch between the channel's open and closed states. The
2372:
Boyadjiev SA, Jabs EW, LaBuda M, Jamal JE, Torbergsen T, Ptácek LJ, Rogers RC, Nyberg-Hansen R, Opjordsmoen S, Zeller CB, Stine OC, Stalker HJ, Zori RT, Shapiro RE (May 1999). "Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23".
68:
2141:
treatments, while silencing its gene increases radiosensitivity. As a result, GJA1 may serve as a target for improving the success of radiotherapeutic treatment of cancer. As a biomarker, GJA1 could also be used to screen young males for risk of testis cancer.
2175:, which function similarly to GJA1. However, both approaches still require a system to target the diseased tissue to avoid inducing developmental abnormalities elsewhere. Thus, a more effective approach entails designing a
328:
227:
2852:
Ghosh S, Kumar A, Chandna S (Jul 2015). "Connexin-43 downregulation in G2/M phase enriched tumour cells causes extensive low-dose hyper-radiosensitivity (HRS) associated with mitochondrial apoptotic events".
2887:
Boros-Rausch, A., Shynlova, O., & Lye, S. J. (2021). "A Broad-Spectrum
Chemokine Inhibitor Blocks Inflammation-Induced Myometrial Myocyte-Macrophage Crosstalk and Myometrial Contraction".
2003:
cells. GJA1 has also been observed to localize to the mitochondria, where it promotes cell survival by downregulating the intrinsic apoptotic pathway during conditions of oxidative stress.
2408:
Fishman GI, Eddy RL, Shows TB, Rosenthal L, Leinwand LA (May 1991). "The human connexin gene family of gap junction proteins: distinct chromosomal locations but similar structures".
2171:, such as danegaptide, have reached clinical trials for treating cardiac pathologies by enhancing GJA1 expression. Alternatively, drugs could target complementary connexins, such as
1863:
gap junctions and is purported to play a crucial role in the synchronized contraction of the heart. Despite its key role in the heart and other vital organs, GJA1 has a short
1664:
loops facilitate proper channel docking. Moreover, two extracellular loops form disulfide bonds that interact with two hexamers to form a complete gap junction channel.
1655:
elements, and other proteins. As a result, the C-terminal tail is central to functions such as regulating pH gating and channel assembly. Notably, the DNA region of the
2475:
Cheng JC, Chang HM, Fang L, Sun YP, Leung PC (Jul 2015). "TGF-β1 up-regulates connexin43 expression: a potential mechanism for human trophoblast cell differentiation".
1489:
3054:"Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation"
2644:
4212:
5122:
2137:, though its role as a gap junction protein may also be involved. Moreover, the cytoprotective effects of this protein can promote tumor cell survival in
4857:
4109:
4042:
1914:, where its gap junction function promotes the maturation and activation of these cells and, by extension, the cross-communication necessary to mount an
1129:
1110:
150:
2152:(T3) downregulates the expression of GJA1. This is assumed to be a key mechanism why the conduction velocity in myocardial tissue is reduced in
3093:
Schubert AL, Schubert W, Spray DC, Lisanti MP (May 2002). "Connexin family members target to lipid raft domains and interact with caveolin-1".
2019:
2354:
2336:
3445:
1844:, which are intercellular channels that connect adjacent cells to permit the exchange of low molecular weight molecules, such as small
1329:
1336:
5053:
5036:
5031:
5026:
5021:
2456:
5058:
4156:
3428:
1884:
3003:"Minor perturbations of thyroid homeostasis and major cardiovascular endpoints-Physiological mechanisms and clinical evidence"
3367:
3282:
2319:
1509:
5664:
5659:
5110:
4291:
65:
2652:
5008:
4029:
2298:
4794:
314:
1828:
291:
3387:
5387:
4386:
4164:
3480:
2323:
2302:
2275:
2031:
1876:
1644:
1859:
GJA1 is the most ubiquitously expressed connexin and is detected in most cell types. It is the major protein in
5409:
2535:"Connexin 43 a check-point component of cell proliferation implicated in a wide range of human testis diseases"
1871:
in the heart and may be highly abundant or compensated with other connexins. GJA1 is also largely involved in
1676:
1174:
1497:
5618:
3529:
2595:"Connexin 43 expression on peripheral blood eosinophils: role of gap junctions in transendothelial migration"
1155:
4984:
3896:
2023:
1766:
1684:
213:
188:
130:
3130:"The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein"
5259:
2208:
2133:. Its role in controlling cell motility and polarity was thought to contribute to cancer development and
1596:
1556:
17:
3437:
3421:
2035:
1802:
1493:
327:
226:
5613:
3823:
3360:
320:
219:
117:
5603:
3864:
3740:
3406:
2245:
2062:
1572:
138:
2593:
Vliagoftis H, Ebeling C, Ilarraza R, Mahmudi-Azer S, Abel M, Adamko D, Befus AD, Moqbel R (2014).
5608:
1312:
1291:
1265:
1244:
5639:
3631:
3618:
3605:
3585:
3572:
3537:
2168:
1762:
1672:
3414:
2118:
1717:
1688:
121:, AVSD3, CMDR, CX43, EKVP, GJAL, HLHS1, HSS, ODDD, PPKCA, gap junction protein alpha 1, EKVP3
3052:
Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J (May 2003).
3512:
3353:
3141:
2102:
1979:
While it is a channel protein, GJA1 can also perform channel-independent functions. In the
1973:
1957:
1945:
1648:
1632:
1476:
202:
1575:. As a result of its function, GJA1 is implicated in many biological processes, including
158:
8:
1849:
1713:
3145:
2559:
2534:
5669:
4979:
3855:
3502:
3167:
3029:
3002:
2983:
2940:
2827:
2732:
2621:
2594:
2572:
2500:
2157:
2110:
2070:
2061:
Notably, GJA1 expression has been associated with a wide variety of cancers, including
1576:
1568:
162:
3154:
3129:
2814:
2797:
1790:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
662:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
4017:
3315:
3278:
3249:
3208:
3159:
3110:
3075:
3034:
2987:
2975:
2932:
2911:"A homozygous GJA1 gene mutation causes a Hallermann-Streiff/ODDD spectrum phenotype"
2870:
2819:
2778:
2724:
2626:
2564:
2492:
2425:
2421:
2390:
2130:
2126:
2114:
2106:
2082:
1888:
1832:
Connexin 43 distribution in the rat myocardium (gap junctions between cardiomyocytes)
1809:
1797:
1484:
110:
58:
2944:
2909:
Pizzuti A, Flex E, Mingarelli R, Salpietro C, Zelante L, Dallapiccola B (Mar 2004).
2831:
2736:
2576:
2504:
1426:
4786:
3767:
3305:
3239:
3198:
3171:
3149:
3102:
3065:
3024:
3014:
2967:
2922:
2862:
2809:
2768:
2714:
2616:
2606:
2554:
2546:
2484:
2417:
2382:
2149:
2146:
2055:
2043:
2027:
1773:
1472:
613:
gap junction channel activity involved in cell communication by electrical coupling
407:
338:
282:
237:
2719:
2702:
1450:
142:
5322:
3462:
2971:
2866:
2773:
2756:
2122:
1961:
1588:
1438:
382:
166:
2359:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2341:
National Center for
Biotechnology Information, U.S. National Library of Medicine
608:
gap junction channel activity involved in cardiac conduction electrical coupling
5118:
3805:
3294:"Connexin expression and turnover : implications for cardiac excitability"
3244:
3227:
2958:
Delmar M, Makita N (May 2012). "Cardiac connexins, mutations and arrhythmias".
2153:
1988:
1969:
1880:
1560:
483:
2550:
5653:
5072:
4745:
3272:
3019:
2086:
2051:
1992:
1953:
1868:
1785:
1661:
1628:
594:
5105:
5003:
3336:
3310:
3293:
657:
543:
421:
5425:
4816:
3319:
3253:
3212:
3203:
3186:
3114:
3079:
3070:
3053:
3038:
2979:
2936:
2874:
2823:
2782:
2728:
2630:
2568:
2496:
2394:
2386:
2184:
2138:
2094:
2090:
2078:
2047:
1949:
1915:
1903:
1841:
1652:
1584:
1552:
565:
400:
179:
3163:
2896:
2611:
2429:
1376:
1371:
5355:
5350:
5345:
5340:
5227:
5066:
3441:
2164:
2098:
2074:
2000:
1984:
1941:
1926:
1892:
1853:
1616:
1219:
1200:
3228:"Association of connexin43 with a receptor protein tyrosine phosphatase"
2533:
Chevallier D, Carette D, Segretain D, Gilleron J, Pointis G (Apr 2013).
1930:
960:
cell communication by electrical coupling involved in cardiac conduction
41:
5335:
4701:
4069:
4037:
2239:
2134:
2066:
1934:
1922:
1907:
1692:
1640:
1624:
1620:
1564:
299:
196:
146:
3106:
2927:
2910:
2488:
1867:(only two to four hours), indicating that the protein undergoes daily
87:
5420:
5330:
2592:
2196:
2191:
to knock down only mutant GJA1 mRNA, thus allowing the expression of
2188:
2180:
1980:
1864:
1778:
1636:
1074:
366:
353:
265:
252:
154:
3436:
2798:"Connexin43 mRNA contains a functional internal ribosome entry site"
1933:, to promote uterine muscle contraction and excitation during human
5433:
4781:
3760:
3755:
3750:
3745:
3677:
3672:
2270:
2192:
2011:
1896:
1837:
1548:
1433:
1360:
3051:
2532:
5560:
5317:
5153:
3654:
3649:
3644:
1744:
1612:
1592:
1537:
1186:
1141:
1059:
1055:
2757:"Channel-independent influence of connexin 43 on cell migration"
134:
5237:
5232:
4966:
4961:
4907:
4902:
4718:
4706:
4696:
4691:
4679:
4674:
4669:
4556:
4551:
4546:
4438:
4374:
4369:
4364:
4359:
4354:
4349:
4344:
4279:
4274:
4264:
4259:
4254:
4205:
4200:
4190:
4185:
4062:
4057:
4052:
4047:
3953:
3948:
3943:
3933:
3928:
3918:
3913:
3843:
3838:
3833:
3828:
3731:
3726:
3721:
3716:
3704:
3699:
3694:
3689:
3598:
3565:
3560:
3555:
3550:
2250:
2046:, even though connexin-43 is the most abundant protein forming
1965:
1919:
1911:
1872:
1600:
1580:
1504:
1397:
1344:
1096:
574:
3345:
3225:
2908:
1660:
transmembrane domains form the gap junction channel while the
850:
positive regulation of cell communication by chemical coupling
5471:
5402:
5397:
5392:
5309:
5296:
5291:
5286:
5281:
5276:
5271:
5222:
5215:
5210:
5205:
5200:
5195:
5190:
5185:
5180:
5168:
5163:
5158:
5148:
5143:
5138:
5133:
5048:
4992:
4949:
4944:
4939:
4934:
4929:
4924:
4919:
4897:
4892:
4887:
4882:
4877:
4872:
4867:
4848:
4843:
4838:
4833:
4821:
4738:
4733:
4728:
4713:
4651:
4646:
4641:
4632:
4627:
4613:
4608:
4599:
4594:
4589:
4580:
4575:
4566:
4561:
4528:
4523:
4518:
4513:
4504:
4495:
4490:
4485:
4476:
4471:
4466:
4461:
4452:
4447:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
4269:
4239:
4234:
4229:
4224:
4195:
4144:
4139:
4134:
4129:
4119:
4114:
4094:
4079:
4074:
3989:
3984:
3979:
3974:
3958:
3938:
3923:
3884:
3879:
3874:
3869:
3777:
3772:
3495:
3490:
3485:
3187:"Casein kinase 1 regulates connexin-43 gap junction assembly"
2257:
2233:
2176:
1996:
1860:
3092:
5551:
5546:
5541:
5531:
5526:
5521:
5511:
5506:
5501:
5496:
5491:
5486:
5481:
5466:
5461:
5456:
5451:
5446:
5380:
5375:
5370:
5365:
5360:
5266:
5254:
5249:
5244:
5175:
5128:
5092:
5087:
5082:
5077:
4804:
4622:
4180:
3517:
3507:
3340:
2703:"Syndromic and non-syndromic disease-linked Cx43 mutations"
2227:
2221:
2215:
2172:
2015:
1845:
1739:
1680:
1544:
1466:
1445:
1421:
1879:
1 (TGF-β1) was observed to induce GJA1 expression via the
1707:
1635:
four times, leaving its C- and N-terminals exposed to the
995:
positive regulation of I-kappaB kinase/NF-kappaB signaling
950:
positive regulation of cytosolic calcium ion concentration
4124:
4084:
2407:
1756:
3337:
Page for
Connexin-43 internal ribosome entry site (IRES)
3226:
Giepmans BN, Feiken E, Gebbink MF, Moolenaar WH (2003).
2457:"Entrez Gene: GJA1 gap junction protein, alpha 1, 43kDa"
2371:
890:
negative regulation of cardiac muscle cell proliferation
390:
2649:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
2645:"Protein sequence of human GJA1 (Uniprot ID: P17302)"
970:
negative regulation of endothelial cell proliferation
555:
2754:
860:
negative regulation of cell population proliferation
2795:
1999:and heart development, as well as wound-healing in
3291:
3000:
2761:Biochimica et Biophysica Acta (BBA) - Biomembranes
2315:
2313:
2311:
2294:
2292:
2290:
3127:
2851:
2474:
1040:cellular response to parathyroid hormone stimulus
337:
236:
5651:
5594:
2696:
2694:
2692:
2690:
2207:Gap junction protein, alpha 1 has been shown to
2167:, an antiarrhythmic peptide-based drug, and its
1035:regulation of transmembrane transporter activity
825:regulation of bicellular tight junction assembly
820:positive regulation of protein catabolic process
2847:
2845:
2843:
2841:
2750:
2748:
2746:
2688:
2686:
2684:
2682:
2680:
2678:
2676:
2674:
2672:
2670:
2588:
2586:
2308:
2287:
1701:Connexin-43 internal ribosome entry site (IRES)
930:negative regulation of DNA biosynthetic process
925:positive regulation of behavioral fear response
2528:
2526:
2524:
2522:
2520:
2518:
2516:
2514:
2470:
2468:
2466:
2320:GRCm38: Ensembl release 89: ENSMUSG00000050953
3422:
3361:
3292:Saffitz JE, Laing JG, Yamada KA (Apr 2000).
3219:
3178:
3086:
3045:
2957:
2902:
2838:
2743:
2667:
2583:
885:positive regulation of glomerular filtration
3270:
3184:
3121:
2755:Kameritsch P, Pogoda K, Pohl U (Aug 2012).
2511:
2463:
2365:
2299:GRCh38: Ensembl release 89: ENSG00000152661
915:atrial cardiac muscle cell action potential
3429:
3415:
3368:
3354:
2796:Schiavi A, Hudder A, Werner R (Dec 1999).
2401:
1706:
1396:
4013:
3458:
3309:
3243:
3202:
3153:
3069:
3028:
3018:
2926:
2813:
2772:
2718:
2620:
2610:
2558:
1025:cell communication by electrical coupling
2451:
2449:
2447:
2445:
2443:
2441:
2439:
2006:
1925:directly physically couple with uterine
1827:
1669:connexin-43 internal ribosome entry site
1639:. The C-terminal tail is composed of 50
1631:domains. The protein passes through the
935:positive regulation of insulin secretion
835:cellular response to mechanical stimulus
5582:
3801:
3001:Müller P, Leow MK, Dietrich JW (2022).
2042:most often do not present with cardiac
2014:in this gene have been associated with
1902:Furthermore, GJA1 is expressed in many
880:positive regulation of vasoconstriction
14:
5652:
3396:: Connexin 43 Carboxyl Terminal Domain
1940:In addition, GJA1 can be found in the
1918:response. It has also been shown that
628:ion transmembrane transporter activity
5581:
4766:
4012:
3800:
3457:
3410:
3349:
2700:
2436:
1995:. This function has been observed in
784:integral component of plasma membrane
342:
303:
298:
241:
200:
195:
3007:Frontiers in Cardiovascular Medicine
2539:Cellular and Molecular Life Sciences
1968:development through controlling the
1647:sites, as well as binding sites for
1402:connexin 43 carboxyl terminal domain
855:negative regulation of wound healing
4795:Calcium-activated chloride channels
3277:. New York: Springer. p. 574.
3191:The Journal of Biological Chemistry
3058:The Journal of Biological Chemistry
2034:; and heart malformations, such as
940:regulation of calcium ion transport
436:dorsal motor nucleus of vagus nerve
24:
3865:Amiloride-sensitive cation channel
3263:
3128:Giepmans BN, Moolenaar WH (1998).
875:negative regulation of cell growth
663:disordered domain specific binding
638:transmembrane transporter activity
25:
5681:
4767:
3328:
3232:Cell Communication & Adhesion
1599:(ODDD), heart malformations, and
1540:that in humans is encoded by the
769:Golgi-associated vesicle membrane
3386:
3185:Cooper CD, Lampe PD (Nov 2002).
564:
326:
319:
313:
290:
225:
218:
212:
187:
40:
5388:Voltage-dependent anion channel
3481:Inositol trisphosphate receptor
3375:
2994:
2951:
2881:
2789:
2637:
2276:Hypoplastic left heart syndrome
2202:
1960:, where it plays a key role in
1877:transforming growth factor-beta
1840:family, GJA1 is a component of
1645:post-translational modification
1555:, which allow for gap junction
980:protein complex oligomerization
900:neuron projection morphogenesis
618:protein domain specific binding
5410:General bacterial porin family
2477:Journal of Cellular Physiology
2347:
2329:
1895:cell differentiation into the
1687:(IRES) allows cap independent
1010:response to lipopolysaccharide
910:response to fluid shear stress
774:endoplasmic reticulum membrane
739:integral component of membrane
575:More reference expression data
544:More reference expression data
460:Region I of hippocampus proper
13:
1:
3155:10.1016/S0960-9822(07)00375-2
2960:Current Opinion in Cardiology
2815:10.1016/S0014-5793(99)01699-3
2720:10.1016/j.febslet.2013.12.022
2599:BioMed Research International
2281:
2054:and are essential for normal
2026:, which is linked to cardiac
1461:Available protein structures:
895:chronic inflammatory response
653:gap junction channel activity
311:
210:
27:Protein-coding gene in humans
2972:10.1097/HCO.0b013e328352220e
2867:10.1016/j.canlet.2015.03.046
2774:10.1016/j.bbamem.2011.11.016
2422:10.1016/0888-7543(91)90507-B
2024:sudden infant death syndrome
1983:, the protein regulates the
1685:internal ribosome entry site
1606:
1522:Gap junction alpha-1 protein
709:mitochondrial outer membrane
7:
5665:Cis-regulatory RNA elements
5660:Genes on human chromosome 6
3271:Harris AL, Locke D (2009).
2264:
2032:Hallermann–Streiff syndrome
2020:craniometaphyseal dysplasia
1987:network and, by extension,
1929:through GJA1, transferring
1875:development. For instance,
1823:
1597:oculodentodigital dysplasia
1557:intercellular communication
975:ion transmembrane transport
965:response to peptide hormone
10:
5686:
4829:Chloride Channel Accessory
3438:Membrane transport protein
3245:10.1080/cac.10.4-6.201.205
2897:doi: 10.3390/cells11010128
2195:GJA1 and retaining normal
2036:viscero-atrial heterotaxia
1691:during conditions such as
658:signal transducer activity
5635:
5590:
5577:
5418:
5307:
5103:
5001:
4977:
4779:
4775:
4762:
4385:
4290:
4155:
4028:
4024:
4008:
3895:
3854:
3824:Epithelial sodium channel
3816:
3812:
3796:
3528:
3473:
3469:
3453:
3381:
2551:10.1007/s00018-012-1121-3
2355:"Mouse PubMed Reference:"
2337:"Human PubMed Reference:"
1808:
1796:
1784:
1772:
1755:
1750:
1738:
1730:
1725:
1705:
1700:
1551:, GJA1 is a component of
1503:
1483:
1465:
1460:
1456:
1444:
1432:
1420:
1412:
1407:
1395:
1390:
1375:
1370:
1366:
1359:
1343:
1330:Chr 6: 121.44 – 121.45 Mb
1324:
1309:
1305:
1288:
1284:
1277:
1262:
1258:
1241:
1237:
1230:
1217:
1213:
1198:
1194:
1185:
1172:
1168:
1153:
1149:
1140:
1127:
1123:
1108:
1104:
1095:
1080:
1073:
1069:
1053:
1015:response to retinoic acid
593:
589:
572:
563:
554:
541:
490:
481:
428:
419:
389:
381:
377:
360:
347:
310:
289:
280:
276:
259:
246:
209:
186:
177:
173:
128:
125:
115:
108:
103:
84:
79:
62:
57:
52:
48:
39:
34:
3741:Cation channels of sperm
3020:10.3389/fcvm.2022.942971
2246:Tight junction protein 1
2063:nasopharyngeal carcinoma
1337:Chr 10: 56.25 – 56.28 Mb
432:external globus pallidus
3311:10.1161/01.res.86.7.723
1619:. GJA1 contains a long
985:endothelium development
920:transmembrane transport
3204:10.1074/jbc.M209427200
3071:10.1074/jbc.M213283200
2387:10.1006/geno.1999.5814
1833:
1547:on chromosome 6. As a
1030:epididymis development
344:10 B4|10 28.64 cM
3817:Constitutively active
2701:Laird DW (Apr 2014).
2119:endometrial carcinoma
2103:adrenocortical tumors
2007:Clinical significance
1958:primary spermatocytes
1831:
1718:sequence conservation
1649:transcription factors
1627:domain, and multiple
845:gap junction assembly
734:extracellular exosome
714:endoplasmic reticulum
305:Chromosome 10 (mouse)
3298:Circulation Research
2156:, thereby promoting
1974:blood-testis barrier
1946:seminiferous tubules
1850:secondary messengers
1633:phospholipid bilayer
1005:response to ischemia
203:Chromosome 6 (human)
80:List of PDB id codes
53:Available structures
5584:By gating mechanism
3197:(47): 44962–44968.
3146:1998CBio....8..931G
3064:(20): 18682–18688.
2612:10.1155/2014/803257
1836:As a member of the
1714:secondary structure
1611:GJA1 is a 43.0 kDa
1000:signal transduction
955:cell-cell signaling
905:response to glucose
704:multivesicular body
5111:TRP cation channel
5009:CNG cation channel
4292:Tandem pore domain
3503:Ryanodine receptor
3274:Connexins, A Guide
2183:oligonucleotides,
2158:cardiac arrhythmia
2111:cervical carcinoma
2071:hemangiopericytoma
1889:signaling pathways
1834:
1577:muscle contraction
1175:ENSMUSG00000050953
840:vascular transport
830:cell communication
815:muscle contraction
808:Biological process
672:Cellular component
633:PDZ domain binding
623:SH3 domain binding
601:Molecular function
5647:
5646:
5631:
5630:
5627:
5626:
5619:Stretch-activated
5596:Ion channel class
5573:
5572:
5569:
5568:
4758:
4757:
4754:
4753:
4030:Calcium-activated
4018:Potassium channel
4004:
4003:
4000:
3999:
3792:
3791:
3788:
3787:
3404:
3403:
3284:978-1-934115-46-6
3107:10.1021/bi0121656
3101:(18): 5754–5764.
2928:10.1002/humu.9220
2655:on 5 October 2015
2489:10.1002/jcp.24902
2131:testicular cancer
2127:thyroid carcinoma
2115:ovarian carcinoma
2107:renal cell cancer
2083:esophageal cancer
1821:
1820:
1528:), also known as
1519:
1518:
1515:
1514:
1510:structure summary
1386:
1385:
1382:
1381:
1355:
1354:
1320:
1319:
1299:
1298:
1273:
1272:
1252:
1251:
1226:
1225:
1207:
1206:
1181:
1180:
1162:
1161:
1136:
1135:
1117:
1116:
1065:
1064:
870:heart development
865:apoptotic process
799:intercalated disc
585:
584:
581:
580:
550:
549:
537:
536:
475:
474:
373:
372:
272:
271:
99:
98:
95:
94:
63:Ortholog search:
16:(Redirected from
5677:
5592:
5591:
5579:
5578:
4787:Chloride channel
4777:
4776:
4764:
4763:
4157:Inward-rectifier
4026:
4025:
4010:
4009:
3814:
3813:
3798:
3797:
3768:Two-pore channel
3471:
3470:
3455:
3454:
3431:
3424:
3417:
3408:
3407:
3390:
3370:
3363:
3356:
3347:
3346:
3323:
3313:
3288:
3258:
3257:
3247:
3238:(4–6): 201–205.
3223:
3217:
3216:
3206:
3182:
3176:
3175:
3157:
3125:
3119:
3118:
3090:
3084:
3083:
3073:
3049:
3043:
3042:
3032:
3022:
2998:
2992:
2991:
2955:
2949:
2948:
2930:
2906:
2900:
2885:
2879:
2878:
2849:
2836:
2835:
2817:
2793:
2787:
2786:
2776:
2767:(8): 1993–2001.
2752:
2741:
2740:
2722:
2713:(8): 1339–1348.
2698:
2665:
2664:
2662:
2660:
2651:. Archived from
2641:
2635:
2634:
2624:
2614:
2590:
2581:
2580:
2562:
2545:(7): 1207–1220.
2530:
2509:
2508:
2483:(7): 1558–1566.
2472:
2461:
2460:
2453:
2434:
2433:
2405:
2399:
2398:
2369:
2363:
2362:
2351:
2345:
2344:
2333:
2327:
2317:
2306:
2296:
2163:Currently, only
2150:triiodothyronine
2056:action potential
1972:proteins in the
1710:
1698:
1697:
1615:composed of 382
1458:
1457:
1400:
1388:
1387:
1368:
1367:
1339:
1332:
1315:
1303:
1302:
1294:
1282:
1281:
1278:RefSeq (protein)
1268:
1256:
1255:
1247:
1235:
1234:
1211:
1210:
1192:
1191:
1166:
1165:
1147:
1146:
1121:
1120:
1102:
1101:
1071:
1070:
794:connexin complex
648:connexin binding
591:
590:
577:
568:
561:
560:
546:
486:
484:Top expressed in
479:
478:
424:
422:Top expressed in
417:
416:
396:
395:
379:
378:
369:
356:
345:
330:
323:
317:
306:
294:
278:
277:
268:
255:
244:
229:
222:
216:
205:
191:
175:
174:
169:
167:GJA1 - orthologs
120:
113:
90:
77:
76:
71:
50:
49:
44:
32:
31:
21:
5685:
5684:
5680:
5679:
5678:
5676:
5675:
5674:
5650:
5649:
5648:
5643:
5623:
5586:
5565:
5414:
5313:
5303:
5099:
4997:
4973:
4771:
4750:
4664:
4541:
4398:
4381:
4286:
4250:
4220:
4176:
4168:
4151:
4105:
4020:
3996:
3969:
3908:
3891:
3850:
3808:
3784:
3667:
3639:
3626:
3613:
3593:
3580:
3545:
3524:
3465:
3463:Calcium channel
3449:
3435:
3405:
3400:
3397:
3391:
3377:
3374:
3331:
3326:
3285:
3266:
3264:Further reading
3261:
3224:
3220:
3183:
3179:
3140:(16): 931–934.
3134:Current Biology
3126:
3122:
3091:
3087:
3050:
3046:
2999:
2995:
2956:
2952:
2907:
2903:
2886:
2882:
2850:
2839:
2794:
2790:
2753:
2744:
2699:
2668:
2658:
2656:
2643:
2642:
2638:
2591:
2584:
2531:
2512:
2473:
2464:
2455:
2454:
2437:
2406:
2402:
2370:
2366:
2353:
2352:
2348:
2335:
2334:
2330:
2318:
2309:
2297:
2288:
2284:
2267:
2205:
2147:thyroid hormone
2123:prostate cancer
2009:
1962:spermatogenesis
1891:, resulting in
1826:
1721:
1675:present in the
1609:
1589:spermatogenesis
1573:differentiation
1559:(GJIC) between
1403:
1377:View/Edit Mouse
1372:View/Edit Human
1335:
1328:
1325:Location (UCSC)
1311:
1290:
1264:
1243:
1156:ENSG00000152661
1049:
1020:decidualization
803:
754:plasma membrane
749:Golgi apparatus
729:fascia adherens
667:
643:protein binding
573:
542:
533:
528:
524:
520:
516:
512:
508:
504:
500:
496:
482:
471:
466:
462:
458:
454:
450:
446:
444:parietal pleura
442:
438:
434:
420:
364:
351:
343:
333:
332:
331:
324:
304:
281:Gene location (
263:
250:
242:
232:
231:
230:
223:
201:
178:Gene location (
129:
116:
109:
86:
64:
28:
23:
22:
15:
12:
11:
5:
5683:
5673:
5672:
5667:
5662:
5645:
5644:
5636:
5633:
5632:
5629:
5628:
5625:
5624:
5622:
5621:
5616:
5611:
5606:
5600:
5598:
5588:
5587:
5575:
5574:
5571:
5570:
5567:
5566:
5564:
5563:
5558:
5557:
5556:
5555:
5554:
5549:
5544:
5536:
5535:
5534:
5529:
5524:
5516:
5515:
5514:
5509:
5504:
5499:
5494:
5489:
5484:
5476:
5475:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
5430:
5428:
5416:
5415:
5413:
5412:
5407:
5406:
5405:
5400:
5395:
5385:
5384:
5383:
5378:
5373:
5368:
5363:
5358:
5353:
5348:
5343:
5338:
5327:
5325:
5311:
5305:
5304:
5302:
5301:
5300:
5299:
5294:
5289:
5284:
5279:
5274:
5264:
5263:
5262:
5257:
5247:
5242:
5241:
5240:
5235:
5230:
5220:
5219:
5218:
5213:
5208:
5203:
5198:
5193:
5188:
5183:
5173:
5172:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5126:
5115:
5113:
5101:
5100:
5098:
5097:
5096:
5095:
5090:
5085:
5080:
5075:
5063:
5062:
5061:
5056:
5051:
5041:
5040:
5039:
5034:
5029:
5024:
5013:
5011:
4999:
4998:
4996:
4995:
4989:
4987:
4985:Proton channel
4975:
4974:
4972:
4971:
4970:
4969:
4964:
4954:
4953:
4952:
4947:
4942:
4937:
4932:
4927:
4922:
4912:
4911:
4910:
4905:
4900:
4895:
4890:
4885:
4880:
4875:
4870:
4860:
4855:
4854:
4853:
4852:
4851:
4846:
4841:
4836:
4826:
4825:
4824:
4819:
4809:
4808:
4807:
4791:
4789:
4773:
4772:
4760:
4759:
4756:
4755:
4752:
4751:
4749:
4748:
4743:
4742:
4741:
4736:
4731:
4721:
4716:
4711:
4710:
4709:
4704:
4699:
4694:
4684:
4683:
4682:
4677:
4672:
4662:
4657:
4656:
4655:
4654:
4649:
4644:
4637:
4636:
4635:
4630:
4625:
4618:
4617:
4616:
4611:
4604:
4603:
4602:
4597:
4592:
4585:
4584:
4583:
4578:
4571:
4570:
4569:
4564:
4559:
4554:
4549:
4539:
4534:
4533:
4532:
4531:
4526:
4521:
4516:
4509:
4508:
4507:
4500:
4499:
4498:
4493:
4488:
4481:
4480:
4479:
4474:
4469:
4464:
4457:
4456:
4455:
4450:
4443:
4442:
4441:
4436:
4431:
4426:
4421:
4416:
4411:
4406:
4396:
4391:
4389:
4383:
4382:
4380:
4379:
4378:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4296:
4294:
4288:
4287:
4285:
4284:
4283:
4282:
4277:
4272:
4267:
4262:
4257:
4248:
4244:
4243:
4242:
4237:
4232:
4227:
4218:
4210:
4209:
4208:
4203:
4198:
4193:
4188:
4183:
4174:
4170:
4166:
4161:
4159:
4153:
4152:
4150:
4149:
4148:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4103:
4099:
4098:
4097:
4089:
4088:
4087:
4082:
4077:
4067:
4066:
4065:
4060:
4055:
4050:
4045:
4034:
4032:
4022:
4021:
4006:
4005:
4002:
4001:
3998:
3997:
3995:
3994:
3993:
3992:
3987:
3982:
3977:
3967:
3963:
3962:
3961:
3956:
3951:
3946:
3941:
3936:
3931:
3926:
3921:
3916:
3906:
3901:
3899:
3893:
3892:
3890:
3889:
3888:
3887:
3882:
3877:
3872:
3861:
3859:
3852:
3851:
3849:
3848:
3847:
3846:
3841:
3836:
3831:
3820:
3818:
3810:
3809:
3806:Sodium channel
3794:
3793:
3790:
3789:
3786:
3785:
3783:
3782:
3781:
3780:
3775:
3765:
3764:
3763:
3758:
3753:
3748:
3737:
3736:
3735:
3734:
3729:
3724:
3719:
3709:
3708:
3707:
3702:
3697:
3692:
3682:
3681:
3680:
3675:
3665:
3660:
3659:
3658:
3657:
3652:
3647:
3637:
3629:
3624:
3616:
3611:
3603:
3602:
3601:
3591:
3583:
3578:
3570:
3569:
3568:
3563:
3558:
3553:
3543:
3534:
3532:
3526:
3525:
3523:
3522:
3521:
3520:
3515:
3510:
3500:
3499:
3498:
3493:
3488:
3477:
3475:
3467:
3466:
3451:
3450:
3434:
3433:
3426:
3419:
3411:
3402:
3401:
3399:
3398:
3392:
3385:
3382:
3379:
3378:
3373:
3372:
3365:
3358:
3350:
3344:
3343:
3334:
3330:
3329:External links
3327:
3325:
3324:
3304:(7): 723–728.
3289:
3283:
3267:
3265:
3262:
3260:
3259:
3218:
3177:
3120:
3085:
3044:
2993:
2966:(3): 236–241.
2950:
2915:Human Mutation
2901:
2880:
2855:Cancer Letters
2837:
2808:(3): 118–122.
2788:
2742:
2666:
2636:
2582:
2510:
2462:
2435:
2416:(1): 250–256.
2400:
2364:
2346:
2328:
2307:
2285:
2283:
2280:
2279:
2278:
2273:
2266:
2263:
2262:
2261:
2254:
2248:
2243:
2237:
2231:
2225:
2219:
2204:
2201:
2154:thyrotoxicosis
2052:cardiomyocytes
2048:gap junctional
2008:
2005:
1989:cell migration
1970:tight junction
1852:, to maintain
1825:
1822:
1819:
1818:
1813:
1806:
1805:
1800:
1794:
1793:
1788:
1782:
1781:
1776:
1770:
1769:
1760:
1753:
1752:
1748:
1747:
1742:
1736:
1735:
1732:
1728:
1727:
1723:
1722:
1711:
1703:
1702:
1683:of GJA1. This
1608:
1605:
1517:
1516:
1513:
1512:
1507:
1501:
1500:
1487:
1481:
1480:
1470:
1463:
1462:
1454:
1453:
1448:
1442:
1441:
1436:
1430:
1429:
1424:
1418:
1417:
1414:
1410:
1409:
1405:
1404:
1401:
1393:
1392:
1384:
1383:
1380:
1379:
1374:
1364:
1363:
1357:
1356:
1353:
1352:
1350:
1348:
1341:
1340:
1333:
1326:
1322:
1321:
1318:
1317:
1307:
1306:
1300:
1297:
1296:
1286:
1285:
1279:
1275:
1274:
1271:
1270:
1260:
1259:
1253:
1250:
1249:
1239:
1238:
1232:
1228:
1227:
1224:
1223:
1215:
1214:
1208:
1205:
1204:
1196:
1195:
1189:
1183:
1182:
1179:
1178:
1170:
1169:
1163:
1160:
1159:
1151:
1150:
1144:
1138:
1137:
1134:
1133:
1125:
1124:
1118:
1115:
1114:
1106:
1105:
1099:
1093:
1092:
1087:
1082:
1078:
1077:
1067:
1066:
1063:
1062:
1051:
1050:
1048:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
990:response to pH
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
811:
809:
805:
804:
802:
801:
796:
791:
786:
781:
779:Golgi membrane
776:
771:
766:
761:
759:early endosome
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
694:focal adhesion
691:
686:
681:
675:
673:
669:
668:
666:
665:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
570:
569:
558:
552:
551:
548:
547:
539:
538:
535:
534:
532:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
488:
487:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
413:
412:
404:
393:
387:
386:
383:RNA expression
375:
374:
371:
370:
362:
358:
357:
349:
346:
341:
335:
334:
325:
318:
312:
308:
307:
302:
296:
295:
287:
286:
274:
273:
270:
269:
261:
257:
256:
248:
245:
240:
234:
233:
224:
217:
211:
207:
206:
199:
193:
192:
184:
183:
171:
170:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
9:
6:
4:
3:
2:
5682:
5671:
5668:
5666:
5663:
5661:
5658:
5657:
5655:
5642:
5641:
5634:
5620:
5617:
5615:
5614:Voltage-gated
5612:
5610:
5607:
5605:
5602:
5601:
5599:
5597:
5593:
5589:
5585:
5580:
5576:
5562:
5559:
5553:
5550:
5548:
5545:
5543:
5540:
5539:
5537:
5533:
5530:
5528:
5525:
5523:
5520:
5519:
5517:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5479:
5477:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5440:
5439:
5437:
5436:
5435:
5432:
5431:
5429:
5427:
5424:
5422:
5417:
5411:
5408:
5404:
5401:
5399:
5396:
5394:
5391:
5390:
5389:
5386:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5333:
5332:
5329:
5328:
5326:
5324:
5321:
5319:
5315:
5306:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5269:
5268:
5265:
5261:
5258:
5256:
5253:
5252:
5251:
5248:
5246:
5243:
5239:
5236:
5234:
5231:
5229:
5226:
5225:
5224:
5221:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5178:
5177:
5174:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5131:
5130:
5127:
5124:
5120:
5117:
5116:
5114:
5112:
5109:
5107:
5102:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5076:
5074:
5071:
5070:
5069:
5068:
5064:
5060:
5057:
5055:
5052:
5050:
5047:
5046:
5045:
5042:
5038:
5035:
5033:
5030:
5028:
5025:
5023:
5020:
5019:
5018:
5015:
5014:
5012:
5010:
5007:
5005:
5000:
4994:
4991:
4990:
4988:
4986:
4983:
4981:
4976:
4968:
4965:
4963:
4960:
4959:
4958:
4955:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4917:
4916:
4913:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4865:
4864:
4861:
4859:
4856:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4831:
4830:
4827:
4823:
4820:
4818:
4815:
4814:
4813:
4810:
4806:
4803:
4802:
4801:
4798:
4797:
4796:
4793:
4792:
4790:
4788:
4785:
4783:
4778:
4774:
4770:
4769:Miscellaneous
4765:
4761:
4747:
4746:Shaker (gene)
4744:
4740:
4737:
4735:
4732:
4730:
4727:
4726:
4725:
4722:
4720:
4719:minK/ISK-like
4717:
4715:
4712:
4708:
4705:
4703:
4700:
4698:
4695:
4693:
4690:
4689:
4688:
4685:
4681:
4678:
4676:
4673:
4671:
4668:
4667:
4666:
4659:
4658:
4653:
4650:
4648:
4645:
4643:
4640:
4639:
4638:
4634:
4631:
4629:
4626:
4624:
4621:
4620:
4619:
4615:
4612:
4610:
4607:
4606:
4605:
4601:
4598:
4596:
4593:
4591:
4588:
4587:
4586:
4582:
4579:
4577:
4574:
4573:
4572:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4548:
4545:
4544:
4543:
4536:
4535:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4511:
4510:
4506:
4503:
4502:
4501:
4497:
4494:
4492:
4489:
4487:
4484:
4483:
4482:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4459:
4458:
4454:
4451:
4449:
4446:
4445:
4444:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4401:
4400:
4393:
4392:
4390:
4388:
4387:Voltage-gated
4384:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4302:
4301:
4298:
4297:
4295:
4293:
4289:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4252:
4251:
4245:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4222:
4221:
4214:
4211:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4178:
4177:
4171:
4169:
4163:
4162:
4160:
4158:
4154:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4107:
4106:
4100:
4096:
4093:
4092:
4090:
4086:
4083:
4081:
4078:
4076:
4073:
4072:
4071:
4068:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4040:
4039:
4036:
4035:
4033:
4031:
4027:
4023:
4019:
4016:
4011:
4007:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3972:
3971:
3964:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3911:
3910:
3903:
3902:
3900:
3898:
3897:Voltage-gated
3894:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3867:
3866:
3863:
3862:
3860:
3857:
3853:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3826:
3825:
3822:
3821:
3819:
3815:
3811:
3807:
3804:
3799:
3795:
3779:
3776:
3774:
3771:
3770:
3769:
3766:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3743:
3742:
3739:
3738:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3714:
3713:
3710:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3687:
3686:
3683:
3679:
3676:
3674:
3671:
3670:
3669:
3662:
3661:
3656:
3653:
3651:
3648:
3646:
3643:
3642:
3641:
3633:
3630:
3628:
3620:
3617:
3615:
3607:
3604:
3600:
3597:
3596:
3595:
3587:
3584:
3582:
3574:
3571:
3567:
3564:
3562:
3559:
3557:
3554:
3552:
3549:
3548:
3547:
3539:
3536:
3535:
3533:
3531:
3530:Voltage-gated
3527:
3519:
3516:
3514:
3511:
3509:
3506:
3505:
3504:
3501:
3497:
3494:
3492:
3489:
3487:
3484:
3483:
3482:
3479:
3478:
3476:
3472:
3468:
3464:
3461:
3456:
3452:
3447:
3443:
3439:
3432:
3427:
3425:
3420:
3418:
3413:
3412:
3409:
3395:
3389:
3384:
3383:
3380:
3371:
3366:
3364:
3359:
3357:
3352:
3351:
3348:
3342:
3338:
3335:
3333:
3332:
3321:
3317:
3312:
3307:
3303:
3299:
3295:
3290:
3286:
3280:
3276:
3275:
3269:
3268:
3255:
3251:
3246:
3241:
3237:
3233:
3229:
3222:
3214:
3210:
3205:
3200:
3196:
3192:
3188:
3181:
3173:
3169:
3165:
3161:
3156:
3151:
3147:
3143:
3139:
3135:
3131:
3124:
3116:
3112:
3108:
3104:
3100:
3096:
3089:
3081:
3077:
3072:
3067:
3063:
3059:
3055:
3048:
3040:
3036:
3031:
3026:
3021:
3016:
3012:
3008:
3004:
2997:
2989:
2985:
2981:
2977:
2973:
2969:
2965:
2961:
2954:
2946:
2942:
2938:
2934:
2929:
2924:
2920:
2916:
2912:
2905:
2899:PMID 35011690
2898:
2894:
2890:
2884:
2876:
2872:
2868:
2864:
2860:
2856:
2848:
2846:
2844:
2842:
2833:
2829:
2825:
2821:
2816:
2811:
2807:
2803:
2799:
2792:
2784:
2780:
2775:
2770:
2766:
2762:
2758:
2751:
2749:
2747:
2738:
2734:
2730:
2726:
2721:
2716:
2712:
2708:
2704:
2697:
2695:
2693:
2691:
2689:
2687:
2685:
2683:
2681:
2679:
2677:
2675:
2673:
2671:
2654:
2650:
2646:
2640:
2632:
2628:
2623:
2618:
2613:
2608:
2604:
2600:
2596:
2589:
2587:
2578:
2574:
2570:
2566:
2561:
2556:
2552:
2548:
2544:
2540:
2536:
2529:
2527:
2525:
2523:
2521:
2519:
2517:
2515:
2506:
2502:
2498:
2494:
2490:
2486:
2482:
2478:
2471:
2469:
2467:
2458:
2452:
2450:
2448:
2446:
2444:
2442:
2440:
2431:
2427:
2423:
2419:
2415:
2411:
2404:
2396:
2392:
2388:
2384:
2380:
2376:
2368:
2360:
2356:
2350:
2342:
2338:
2332:
2325:
2321:
2316:
2314:
2312:
2304:
2300:
2295:
2293:
2291:
2286:
2277:
2274:
2272:
2269:
2268:
2259:
2255:
2252:
2249:
2247:
2244:
2241:
2238:
2235:
2232:
2229:
2226:
2223:
2220:
2217:
2214:
2213:
2212:
2210:
2200:
2198:
2194:
2190:
2186:
2182:
2178:
2174:
2170:
2166:
2161:
2159:
2155:
2151:
2148:
2143:
2140:
2136:
2132:
2128:
2124:
2120:
2116:
2112:
2108:
2104:
2100:
2096:
2092:
2088:
2087:breast cancer
2084:
2080:
2076:
2072:
2068:
2064:
2059:
2058:propagation.
2057:
2053:
2049:
2045:
2041:
2037:
2033:
2029:
2025:
2021:
2017:
2013:
2004:
2002:
1998:
1994:
1990:
1986:
1982:
1977:
1975:
1971:
1967:
1963:
1959:
1955:
1954:spermatogonia
1951:
1950:Sertoli cells
1947:
1943:
1938:
1936:
1932:
1928:
1924:
1921:
1917:
1913:
1909:
1905:
1900:
1898:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1862:
1857:
1855:
1851:
1847:
1843:
1842:gap junctions
1839:
1830:
1817:
1814:
1811:
1807:
1804:
1801:
1799:
1795:
1792:
1789:
1787:
1783:
1780:
1777:
1775:
1771:
1768:
1764:
1761:
1758:
1754:
1749:
1746:
1743:
1741:
1737:
1733:
1729:
1724:
1719:
1715:
1709:
1704:
1699:
1696:
1694:
1690:
1686:
1682:
1678:
1674:
1670:
1665:
1663:
1662:extracellular
1658:
1654:
1650:
1646:
1643:and includes
1642:
1638:
1634:
1630:
1629:transmembrane
1626:
1622:
1618:
1614:
1604:
1602:
1598:
1594:
1591:, as well as
1590:
1586:
1583:development,
1582:
1578:
1574:
1570:
1569:proliferation
1566:
1562:
1558:
1554:
1553:gap junctions
1550:
1546:
1543:
1539:
1535:
1531:
1527:
1523:
1511:
1508:
1506:
1502:
1499:
1495:
1491:
1488:
1486:
1482:
1478:
1474:
1471:
1468:
1464:
1459:
1455:
1452:
1449:
1447:
1443:
1440:
1437:
1435:
1431:
1428:
1425:
1423:
1419:
1415:
1411:
1406:
1399:
1394:
1389:
1378:
1373:
1369:
1365:
1362:
1358:
1351:
1349:
1346:
1342:
1338:
1334:
1331:
1327:
1323:
1316:
1314:
1308:
1304:
1301:
1295:
1293:
1287:
1283:
1280:
1276:
1269:
1267:
1261:
1257:
1254:
1248:
1246:
1240:
1236:
1233:
1231:RefSeq (mRNA)
1229:
1222:
1221:
1216:
1212:
1209:
1203:
1202:
1197:
1193:
1190:
1188:
1184:
1177:
1176:
1171:
1167:
1164:
1158:
1157:
1152:
1148:
1145:
1143:
1139:
1132:
1131:
1126:
1122:
1119:
1113:
1112:
1107:
1103:
1100:
1098:
1094:
1091:
1088:
1086:
1083:
1079:
1076:
1072:
1068:
1061:
1057:
1052:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
945:ATP transport
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
812:
810:
807:
806:
800:
797:
795:
792:
790:
789:cell junction
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
744:late endosome
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
719:membrane raft
717:
715:
712:
710:
707:
705:
702:
700:
699:mitochondrion
697:
695:
692:
690:
687:
685:
682:
680:
677:
676:
674:
671:
670:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
562:
559:
557:
553:
545:
540:
529:
525:
521:
517:
514:body of femur
513:
510:hair follicle
509:
505:
501:
497:
493:
492:
489:
485:
480:
477:
467:
463:
459:
456:skin of thigh
455:
451:
447:
443:
440:hair follicle
439:
435:
431:
430:
427:
423:
418:
415:
414:
411:
409:
405:
403:
402:
398:
397:
394:
392:
388:
384:
380:
376:
368:
363:
359:
355:
350:
340:
336:
329:
322:
316:
309:
301:
297:
293:
288:
284:
279:
275:
267:
262:
258:
254:
249:
239:
235:
228:
221:
215:
208:
204:
198:
194:
190:
185:
181:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
5637:
5604:Ligand-gated
5595:
5583:
5441:
5426:Gap junction
5419:
5308:
5104:
5065:
5043:
5016:
5002:
4978:
4956:
4914:
4862:
4828:
4811:
4799:
4780:
4768:
4723:
4686:
4660:
4537:
4394:
4299:
4246:
4216:
4172:
4101:
4014:
3965:
3904:
3802:
3711:
3684:
3663:
3635:
3622:
3609:
3589:
3576:
3541:
3474:Ligand-gated
3459:
3442:ion channels
3393:
3301:
3297:
3273:
3235:
3231:
3221:
3194:
3190:
3180:
3137:
3133:
3123:
3098:
3095:Biochemistry
3094:
3088:
3061:
3057:
3047:
3010:
3006:
2996:
2963:
2959:
2953:
2918:
2914:
2904:
2892:
2888:
2883:
2861:(1): 46–59.
2858:
2854:
2805:
2802:FEBS Letters
2801:
2791:
2764:
2760:
2710:
2707:FEBS Letters
2706:
2659:18 September
2657:. Retrieved
2653:the original
2648:
2639:
2602:
2598:
2542:
2538:
2480:
2476:
2413:
2409:
2403:
2381:(1): 34–40.
2378:
2374:
2367:
2358:
2349:
2340:
2331:
2206:
2203:Interactions
2185:transfection
2162:
2144:
2139:radiotherapy
2095:glioblastoma
2091:mesothelioma
2079:colon cancer
2060:
2039:
2010:
1978:
1942:Leydig cells
1939:
1916:inflammatory
1904:immune cells
1901:
1858:
1835:
1720:of IRES_Cx43
1695:and stress.
1668:
1666:
1656:
1653:cytoskeleton
1610:
1595:, including
1585:inflammation
1563:to regulate
1541:
1533:
1529:
1525:
1521:
1520:
1310:
1289:
1263:
1242:
1218:
1199:
1173:
1154:
1128:
1109:
1089:
1084:
764:gap junction
530:otic placode
498:cumulus cell
494:ciliary body
406:
399:
264:121,449,727
251:121,435,595
126:External IDs
85:
29:
5609:Light-gated
4091:IK channel
3376:PDB gallery
2169:derivatives
2165:rotigaptide
2099:lung cancer
2075:liver tumor
2044:arrhythmias
2001:endothelial
1985:microtubule
1908:eosinophils
1893:trophoblast
1854:homeostasis
1726:Identifiers
1689:translation
1673:RNA element
1641:amino acids
1617:amino acids
1530:connexin 43
1408:Identifiers
464:skin of hip
452:human penis
365:56,278,609
352:56,253,426
104:Identifiers
18:Connexin-43
5654:Categories
4812:Bestrophin
4070:SK channel
4038:BK channel
3712:γ-subunits
3685:β-subunits
3668:δ-subunits
3013:: 942971.
2921:(3): 286.
2895:(1): 128.
2605:: 803257.
2326:, May 2017
2305:, May 2017
2282:References
2240:Caveolin 1
2135:metastasis
2067:meningioma
2028:arrhythmia
1923:macrophage
1906:, such as
1812:structures
1803:SO:0000243
1791:GO:0043022
1751:Other data
1712:Predicted
1693:heat shock
1625:N-terminal
1621:C-terminal
1565:cell death
1473:structures
1416:Connexin43
1391:Connexin43
410:(ortholog)
147:HomoloGene
5670:Connexins
5640:disorders
5638:see also
5421:Cytoplasm
5331:Aquaporin
4800:Anoctamin
4623:11.1/hERG
2988:205620477
2197:phenotype
2189:infection
2181:antisense
2050:pores in
2012:Mutations
1981:cytoplasm
1873:embryonic
1865:half-life
1779:Eukaryota
1774:Domain(s)
1734:IRES_Cx43
1637:cytoplasm
1623:tail, an
1607:Structure
1581:embryonic
1439:IPR013124
1313:NP_034418
1292:NP_000156
1266:NM_010288
1245:NM_000165
1075:Orthologs
1045:transport
679:cytoplasm
155:GeneCards
5434:Connexin
4714:minK/ISK
3320:10764404
3254:14681016
3213:12270943
3115:11980479
3080:12637502
3039:36046184
2980:22382502
2945:13345970
2937:14974090
2875:25843295
2832:26020820
2824:10618489
2783:22155212
2737:20651016
2729:24434540
2631:25110696
2577:11855947
2569:22918484
2560:11113700
2505:28968035
2497:25560303
2410:Genomics
2395:10331943
2375:Genomics
2322:–
2301:–
2271:Connexin
2265:See also
2209:interact
2193:wildtype
2179:through
1993:polarity
1948:between
1927:myocytes
1897:placenta
1869:turnover
1838:connexin
1824:Function
1593:diseases
1549:connexin
1536:), is a
1490:RCSB PDB
1434:InterPro
1361:Wikidata
1054:Sources:
724:lysosome
689:membrane
684:endosome
506:gastrula
5561:Innexin
5318:solutes
3172:6434044
3164:9707407
3142:Bibcode
3030:9420854
2622:4109672
2430:1646158
2324:Ensembl
2303:Ensembl
2256:PTPmu (
1937:onset.
1920:uterine
1912:T cells
1763:Cis-reg
1745:RF00487
1679:of the
1613:protein
1601:cancers
1538:protein
1427:PF03508
1187:UniProt
1142:Ensembl
1081:Species
1060:QuickGO
526:condyle
522:decidua
468:decidua
385:pattern
243:6q22.31
111:Aliases
3858:-gated
3856:Proton
3632:T-type
3619:R-type
3606:Q-type
3586:P-type
3573:N-type
3538:L-type
3318:
3281:
3252:
3211:
3170:
3162:
3113:
3078:
3037:
3027:
2986:
2978:
2943:
2935:
2873:
2830:
2822:
2781:
2735:
2727:
2629:
2619:
2575:
2567:
2557:
2503:
2495:
2428:
2393:
2251:CSNK1D
2211:with:
2129:, and
1966:testis
1731:Symbol
1677:5' UTR
1671:is an
1587:, and
1571:, and
1505:PDBsum
1479:
1469:
1451:1.A.24
1413:Symbol
1347:search
1345:PubMed
1220:P23242
1201:P17302
1097:Entrez
556:BioGPS
135:121014
5472:GJA10
5323:Porin
5223:TRPML
4993:HVCN1
4687:KCNIP
4542:α7-12
3446:TC 1A
3168:S2CID
2984:S2CID
2941:S2CID
2889:Cells
2828:S2CID
2733:S2CID
2573:S2CID
2501:S2CID
2258:PTPRM
2253:, and
2234:MAPK7
2187:, or
2177:miRNA
1997:brain
1935:labor
1861:heart
1561:cells
1130:14609
1090:Mouse
1085:Human
1056:Amigo
518:molar
448:vulva
408:Mouse
401:Human
348:Start
283:Mouse
247:Start
180:Human
143:95713
5552:GJD4
5547:GJD3
5542:GJD2
5532:GJC3
5527:GJC2
5522:GJC1
5512:GJB7
5507:GJB6
5502:GJB5
5497:GJB4
5492:GJB3
5487:GJB2
5482:GJB1
5467:GJA9
5462:GJA8
5457:GJA5
5452:GJA4
5447:GJA3
5442:GJA1
5267:TRPV
5250:TRPP
5245:TRPN
5176:TRPM
5129:TRPC
5119:TRPA
4957:CLNS
4915:CLIC
4863:CLCN
4858:CFTR
4805:ANO1
4724:MiRP
4652:12.3
4647:12.2
4642:12.1
4633:11.3
4628:11.2
4614:10.2
4609:10.1
4399:α1-6
4213:GIRK
3627:α2.3
3614:α2.1
3581:α2.2
3394:1r5s
3341:Rfam
3316:PMID
3279:ISBN
3250:PMID
3209:PMID
3160:PMID
3111:PMID
3076:PMID
3035:PMID
2976:PMID
2933:PMID
2871:PMID
2820:PMID
2779:PMID
2765:1818
2725:PMID
2661:2015
2627:PMID
2603:2014
2565:PMID
2493:PMID
2426:PMID
2391:PMID
2228:Cx45
2222:Cx40
2216:Cx37
2173:Cx40
2145:The
2040:GJA1
2016:ODDD
1991:and
1964:and
1952:and
1944:and
1931:Ca²⁺
1910:and
1885:ERK1
1883:and
1881:Smad
1848:and
1846:ions
1816:PDBe
1767:IRES
1759:type
1740:Rfam
1716:and
1681:mRNA
1667:The
1657:GJA1
1545:gene
1542:GJA1
1534:Cx43
1526:GJA1
1498:PDBj
1494:PDBe
1477:ECOD
1467:Pfam
1446:TCDB
1422:Pfam
1111:2697
502:iris
391:Bgee
339:Band
300:Chr.
238:Band
197:Chr.
159:GJA1
131:OMIM
118:GJA1
88:2LL2
69:RCSB
66:PDBe
35:GJA1
5316:(+
5154:4AP
5067:HCN
4600:9.3
4595:9.2
4590:9.1
4581:8.2
4576:8.1
4567:7.5
4562:7.4
4557:7.3
4552:7.2
4547:7.1
4529:6.4
4524:6.3
4519:6.2
4514:6.1
4505:5.1
4496:4.3
4491:4.2
4486:4.1
4477:3.4
4472:3.3
4467:3.2
4462:3.1
4453:2.2
4448:2.1
4439:1.8
4434:1.7
4429:1.6
4424:1.5
4419:1.4
4414:1.3
4409:1.2
4404:1.1
4300:K2P
4280:7.1
4275:6.2
4270:6.1
4265:5.1
4260:4.2
4255:4.1
4240:3.4
4235:3.3
4230:3.2
4225:3.1
4206:2.6
4201:2.4
4196:2.3
4191:2.2
4186:2.1
4181:1.1
4167:ATP
4145:5.1
4140:4.2
4135:4.1
4130:3.1
4125:2.3
4120:2.2
4115:2.1
4110:1.1
4095:IK1
4085:SK3
4080:SK2
4075:SK1
3954:1.9
3949:1.8
3944:1.7
3939:1.6
3934:1.5
3929:1.4
3924:1.3
3919:1.2
3914:1.1
3803:Na:
3655:3.3
3650:3.2
3645:3.1
3599:2.1
3566:1.4
3561:1.3
3556:1.2
3551:1.1
3460:Ca:
3339:at
3306:doi
3240:doi
3199:doi
3195:277
3150:doi
3103:doi
3066:doi
3062:278
3025:PMC
3015:doi
2968:doi
2923:doi
2863:doi
2859:363
2810:doi
2806:464
2769:doi
2715:doi
2711:588
2617:PMC
2607:doi
2555:PMC
2547:doi
2485:doi
2481:230
2418:doi
2383:doi
1956:or
1887:/2
1810:PDB
1757:RNA
1485:PDB
361:End
260:End
163:OMA
151:136
139:MGI
59:PDB
5656::
5538:D
5518:C
5478:B
5438:A
5320:):
5073:FC
4967:1B
4962:1A
4950:L1
4908:KB
4903:KA
4782:Cl
4375:18
4370:17
4365:16
4360:15
4355:13
4350:12
4345:10
4249:ir
4219:ir
4175:ir
4104:Ca
4063:β4
4058:β3
4053:β2
4048:β1
4043:α1
4015:K:
3966:Na
3959:7A
3905:Na
3732:γ4
3727:γ3
3722:γ2
3717:γ1
3705:β4
3700:β3
3695:β2
3690:β1
3636:Ca
3623:Ca
3610:Ca
3590:Ca
3577:Ca
3542:Ca
3440::
3314:.
3302:86
3300:.
3296:.
3248:.
3236:10
3234:.
3230:.
3207:.
3193:.
3189:.
3166:.
3158:.
3148:.
3136:.
3132:.
3109:.
3099:41
3097:.
3074:.
3060:.
3056:.
3033:.
3023:.
3009:.
3005:.
2982:.
2974:.
2964:27
2962:.
2939:.
2931:.
2919:23
2917:.
2913:.
2893:11
2891:.
2869:.
2857:.
2840:^
2826:.
2818:.
2804:.
2800:.
2777:.
2763:.
2759:.
2745:^
2731:.
2723:.
2709:.
2705:.
2669:^
2647:.
2625:.
2615:.
2601:.
2597:.
2585:^
2571:.
2563:.
2553:.
2543:70
2541:.
2537:.
2513:^
2499:.
2491:.
2479:.
2465:^
2438:^
2424:.
2414:10
2412:.
2389:.
2379:58
2377:.
2357:.
2339:.
2310:^
2289:^
2260:).
2199:.
2160:.
2125:,
2121:,
2117:,
2113:,
2109:,
2105:,
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2097:,
2093:,
2089:,
2085:,
2081:,
2077:,
2073:,
2069:,
2065:,
2030:;
2022:;
2018:;
1976:.
1899:.
1856:.
1798:SO
1786:GO
1765:;
1651:,
1603:.
1579:,
1567:,
1496:;
1492:;
1475:/
1058:/
367:bp
354:bp
266:bp
253:bp
161:;
157::
153:;
149::
145:;
141::
137:;
133::
5423::
5403:3
5398:2
5393:1
5381:9
5376:8
5371:7
5366:6
5361:5
5356:4
5351:3
5346:2
5341:1
5336:0
5314:O
5312:2
5310:H
5297:6
5292:5
5287:4
5282:3
5277:2
5272:1
5260:2
5255:1
5238:3
5233:2
5228:1
5216:8
5211:7
5206:6
5201:5
5196:4
5191:3
5186:2
5181:1
5169:7
5164:6
5159:5
5149:4
5144:3
5139:2
5134:1
5125:)
5123:1
5121:(
5108::
5106:M
5093:4
5088:3
5083:2
5078:1
5059:3
5054:2
5049:1
5044:β
5037:4
5032:3
5027:2
5022:1
5017:α
5006::
5004:M
4982::
4980:H
4945:6
4940:5
4935:4
4930:3
4925:2
4920:1
4898:7
4893:6
4888:5
4883:4
4878:3
4873:2
4868:1
4849:4
4844:3
4839:2
4834:1
4822:2
4817:1
4784::
4739:3
4734:2
4729:1
4707:4
4702:3
4697:2
4692:1
4680:3
4675:2
4670:1
4665:β
4663:v
4661:K
4540:v
4538:K
4397:v
4395:K
4340:9
4335:7
4330:6
4325:5
4320:4
4315:3
4310:2
4305:1
4247:K
4217:K
4215:/
4173:K
4165:K
4102:K
3990:4
3985:3
3980:2
3975:1
3970:β
3968:v
3909:α
3907:v
3885:4
3880:3
3875:2
3870:1
3844:δ
3839:γ
3834:β
3829:α
3778:2
3773:1
3761:4
3756:3
3751:2
3746:1
3678:2
3673:1
3666:2
3664:α
3640:α
3638:v
3634:/
3625:v
3621:/
3612:v
3608:/
3594:α
3592:v
3588:/
3579:v
3575:/
3546:α
3544:v
3540:/
3518:3
3513:2
3508:1
3496:3
3491:2
3486:1
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3423:t
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3369:e
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3355:v
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3308::
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3256:.
3242::
3215:.
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3138:8
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2970::
2947:.
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165::
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