774:. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. The enzyme acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.
40:
905:
227:
891:
877:
919:
5979:
693:
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic.
1348:
Huang YJ, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, Bilodeau AS, Bellemare A, Côté M, Herskovits P, Touati M, Turcotte C, Valeanu L, Lemée N, Wilgus H, Bégin I, Bhatia B, Rao K, Neveu N, Brochu E, Pierson J, Hockley DK, Cerasoli DM, Lenz DE, Karatzas CN, Langermann S (Aug 2007).
737:
The enzyme
Acetylcholin esterase, and its inhibition, plays a role in the development of myofascial trigger points and the associated myofascial pain syndrome. By injecting a mouse with acetylcholin esterase inhibitors and electrical stimulation, the muscle develops
598:) (BCHE), also known as cholinesterase, choline esterase II, BChE, BuChE, pseudocholinesterase (PCE), plasma cholinesterase (PChE), serum cholinesterase (SChE), butylcholinesterase, or (most formally) acylcholine acylhydrolase, is produced in the
572:) (ACHE), also known as AChE, choline esterase I, RBC cholinesterase, or erythrocyte cholinesterase, true cholinesterase, choline esterase I, or (most formally) acetylcholine acetylhydrolase, is found primarily in the
474:
triggers a contraction; but for the muscle to relax afterward, rather than remaining locked in a tense state, the acetylcholine must be broken down by a choline esterase. The main type for that purpose is
588:. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.
1294:
Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I (Aug 1991). "Atomic structure of acetylcholinesterase from
Torpedo californica: a prototypic acetylcholine-binding protein".
2218:
3742:
861:
pesticides. In addition to acute poisoning as described above, a semi-acute poisoning characterized by strong mental disturbances can occur. Also, prolonged exposure can cause
1781:
4385:
5460:
754:(or "anticholinesterase") suppresses the action of the enzyme. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent
5406:
4821:
3709:
2211:
1642:
Ali N, Hoque MA, Haque A, Salam KA, Karim MR, Rahman A, Islam K, Saud ZA, Khalek MA, Akhand AA, Hossain M, Mandal A, Karim MR, Miyataka H, Himeno S, Hossain K (2010).
3735:
2990:
3945:
3453:
2380:
4816:
2204:
3728:
3704:
2985:
3406:
4090:
2470:
3325:
2485:
1774:
4070:
2465:
270:
87:
2971:
5068:
4247:
2400:
5229:
4025:
3593:
3518:
3310:
2812:
2807:
2520:
2460:
667:
4886:
4685:
3995:
3305:
3300:
3010:
2995:
2500:
2495:
2440:
2430:
2390:
2270:
1767:
777:
Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the
5325:
4380:
3820:
3815:
3523:
3295:
3040:
2684:
2573:
2395:
2385:
1449:
3950:
3280:
2862:
2719:
2350:
2345:
2340:
2335:
2330:
2305:
2290:
4227:
4170:
4135:
4110:
4015:
3840:
3835:
3200:
2767:
2425:
2405:
5036:
4252:
2530:
2295:
5053:
4525:
3340:
1707:
1704:
ATSDR Case
Studies in Environmental Medicine: Cholinesterase Inhibitors, Including Insecticides and Chemical Warfare Nerve Agents
758:, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death (examples are some
5300:
3175:
2877:
2450:
2285:
1919:
1615:
Holmes JH, Kanfer I, Zwarenstein H (Aug 1978). "Effect of benzodiazepine derivatives on human blood cholinesterase in vitro".
6014:
1431:
1160:
1129:
275:
92:
6004:
5999:
5214:
682:. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants
5315:
5309:
5110:
4860:
2096:
2062:
2048:
1905:
294:
111:
5158:
2979:
2975:
2238:
1351:"Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning"
704:
The presence of ACHE in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by
5698:
5269:
5058:
3762:
2227:
1038:"Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease"
3751:
2057:
559:
282:
99:
5376:
5264:
3577:
1644:"Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh"
679:
5185:
5095:
5048:
4185:
3781:
3120:
3029:
2598:
629:. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with
5854:
5607:
5548:
3115:
2562:
1939:
1854:
5652:
5219:
5209:
4811:
3699:
2013:
1703:
731:
625:
The half-life of BCHE is approximately 10 to 14 days. BCHE levels may be reduced in patients with advanced
730:
Some early research points to genetic butylcholinesterase deficiency as a possible candidate component in
5612:
5504:
5129:
3875:
1517:"Lesions of rat skeletal muscle after local block of acetylcholinesterase and neuromuscular stimulation"
287:
255:
104:
72:
5969:
5198:
5194:
5190:
5106:
4939:
4199:
3925:
3795:
3429:
3369:
1802:
5955:
5942:
5929:
5916:
5903:
5890:
5877:
5839:
5366:
4922:
3130:
3100:
2548:
2134:
1914:
5849:
5803:
5746:
5114:
4963:
4877:
4785:
3673:
3421:
1753:
1743:
751:
739:
592:
566:
512:
335:
152:
1009:
5751:
4983:
4853:
3915:
2897:
2752:
1993:
1974:
1834:
1712:
1749:
1739:
1152:
1146:
6009:
5539:
5178:
4204:
2967:
2699:
2196:
2184:
2043:
1570:"Review of enigmatic MTrPs as a common cause of enigmatic musculoskeletal pain and dysfunction"
842:
709:
581:
546:) under that scheme mean the same thing (confusingly), and acetylcholinesterase is then called
471:
3720:
904:
5772:
5691:
5474:
5371:
5163:
5124:
4988:
4910:
4770:
4719:
4680:
3658:
3607:
3543:
3320:
3265:
2715:
2694:
2540:
2162:
2088:
1446:
805:
698:
511:(BCHE). The difference between the two types has to do with their respective preferences for
508:
488:
218:
1722:
5844:
5657:
5492:
5487:
5420:
5080:
4905:
4765:
4630:
4610:
4450:
4395:
4310:
4100:
3653:
3573:
3170:
2158:
1900:
1655:
1362:
1303:
1248:
1189:
660:
504:
476:
356:
352:
169:
45:
31:
22:
558:
then do not mean the same thing. But such usage is now outdated; the current, unambiguous
376:
340:
193:
157:
8:
5808:
5512:
5482:
5286:
5281:
5205:
5141:
4927:
4780:
4665:
4650:
4585:
4180:
3668:
3330:
3215:
3025:
2827:
1954:
1949:
1178:"Acetylcholinesterase, I. Large-scale purification, homogeneity, and amino Acid analysis"
826:
713:
173:
1759:
1659:
1366:
1307:
1252:
1193:
918:
5741:
5645:
5497:
4978:
4968:
4846:
4700:
4640:
4550:
4475:
4370:
4355:
4345:
3754:
3401:
3396:
3155:
3110:
2932:
2583:
2558:
2375:
2252:
2230:
2187:
1715:
showing the structure of acetylcholinesterase and interactions with various inhibitors.
1678:
1643:
1544:
1492:
1467:
1385:
1350:
1327:
1102:
1090:
973:
948:
467:
1426:(6th ed.). New Delhi: Jaypee Brothers Medical Publications (P) Ltd. p. 565.
1271:
1236:
1212:
1177:
876:
829:, anticholinesterases are also used for reversing medication induced paralysis during
491:(also called choline esterase II or plasma cholinesterase); it is found mainly in the
479:(also called choline esterase I or erythrocyte cholinesterase); it is found mainly in
6019:
5446:
5391:
5359:
5234:
4953:
4790:
4510:
4390:
4270:
3678:
3538:
3433:
3250:
3145:
3095:
2952:
2832:
1944:
1728:
1683:
1624:
1597:
1589:
1536:
1497:
1427:
1390:
1319:
1276:
1217:
1156:
1125:
1094:
1059:
978:
834:
233:
50:
4289:
4285:
4213:
2178:
1532:
1331:
1106:
942:
940:
562:
names and symbols are acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE).
5787:
5782:
5756:
5684:
5522:
5102:
5007:
5002:
4958:
4660:
4470:
4365:
4237:
3800:
3776:
3391:
3210:
3165:
2666:
1794:
1673:
1663:
1581:
1548:
1528:
1487:
1479:
1380:
1370:
1311:
1266:
1256:
1207:
1197:
1086:
1049:
968:
960:
890:
767:
708:, and presence of ACHE can confirm several common types of birth defect, including
480:
431:
347:
164:
1585:
1402:
666:
Clinically useful quantities of butyrylcholinesterase were synthesized in 2007 by
5834:
5818:
5731:
5624:
5438:
5354:
5349:
5344:
5257:
5252:
5012:
4890:
4315:
3551:
3508:
3205:
2942:
2867:
2847:
2638:
2602:
2100:
1859:
1468:"Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome"
1453:
1124:(5th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 546–9.
937:
854:
812:
683:
630:
311:
128:
4838:
4217:
4209:
1483:
964:
678:
An absence or mutation of the BCHE enzyme leads to a medical condition known as
386:
203:
39:
5983:
5872:
5813:
5597:
5592:
5587:
4973:
4948:
4944:
4917:
4495:
4145:
3940:
3885:
3547:
3150:
3090:
2852:
2630:
2626:
2614:
2320:
1355:
Proceedings of the
National Academy of Sciences of the United States of America
1241:
Proceedings of the
National Academy of Sciences of the United States of America
1237:"Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point"
1182:
Proceedings of the
National Academy of Sciences of the United States of America
1151:(6th ed.). Philadelphia, Penns.: Elsevier/Churchill Livingstone. pp.
924:
577:
520:
484:
4221:
5993:
5777:
5736:
5338:
5247:
4997:
4775:
4605:
4575:
4515:
4465:
4460:
4350:
4320:
4266:
4095:
3910:
3845:
3663:
3503:
3489:
3485:
3477:
3425:
3085:
3080:
2947:
2882:
2365:
2280:
2115:
1970:
1593:
1456:. Foundation for Blood Research (September 7, 2007). Retrieved on 2007-11-21.
882:
862:
822:
Cholinesterase levels can be used as an indirect marker of arsenic exposure.
705:
626:
516:
451:
226:
1569:
1516:
1375:
1315:
947:
Colović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM, Vasić VM (May 2013).
5726:
5465:
5396:
5119:
5040:
4690:
4620:
4615:
4530:
4340:
4330:
4281:
4262:
4060:
3980:
3970:
3567:
3563:
3497:
3493:
3445:
3437:
3255:
3220:
3135:
3035:
3020:
2957:
2887:
2837:
2742:
2707:
2678:
2674:
2670:
2658:
2475:
2435:
2410:
2080:
1687:
1668:
1601:
1540:
1501:
1394:
1221:
1077:
Whittaker M (1980). "Plasma cholinesterase variants and the anaesthetist".
1063:
982:
759:
720:
653:
646:
619:
611:
603:
530:
is sometimes used to refer specifically to butyrylcholinesterase, but this
492:
3055:
3050:
1323:
1280:
1261:
1202:
1098:
694:
The selection of an amide-based solution is recommended in such patients.
5950:
5885:
5721:
5640:
5411:
5305:
5168:
5134:
5072:
4795:
4760:
4740:
4655:
4645:
4600:
4580:
4500:
4430:
4420:
4410:
4405:
4375:
4165:
4160:
4150:
4140:
4085:
4050:
4040:
4035:
4030:
4020:
3960:
3935:
3930:
3850:
3683:
3648:
3628:
3555:
3533:
3528:
3513:
3473:
3449:
3416:
3385:
3377:
3359:
3335:
3285:
3270:
3260:
3230:
3225:
3190:
3075:
3070:
3045:
3015:
3000:
2857:
2817:
2802:
2797:
2792:
2787:
2757:
2737:
2662:
2650:
2634:
2618:
2588:
2490:
2455:
2445:
2315:
1881:
1719:
910:
794:
771:
652:
The 3D structure of acetylcholinesterase was first determined in 1991 by
459:
447:
323:
140:
1628:
697:
Elevation of plasma BCHE levels was observed in 90.5% of cases of acute
5617:
4755:
4735:
4695:
4670:
4635:
4625:
4570:
4560:
4555:
4545:
4520:
4485:
4440:
4435:
4415:
4400:
4360:
4325:
4257:
4242:
4232:
3985:
3975:
3920:
3880:
3865:
3643:
3623:
3588:
3481:
3469:
3457:
3364:
3353:
3349:
3290:
3185:
3180:
3160:
3065:
2937:
2892:
2872:
2822:
2777:
2727:
2723:
2711:
2642:
2622:
2610:
2568:
2525:
2515:
2510:
2505:
2480:
2415:
2355:
2300:
2275:
2260:
2027:
830:
786:
782:
755:
687:
595:
569:
443:
318:
135:
1054:
1037:
237:
54:
5924:
5898:
5530:
5329:
5242:
4869:
4595:
4590:
4565:
4540:
4535:
4505:
4455:
4445:
4425:
4295:
4080:
4075:
4065:
3890:
3870:
3860:
3855:
3810:
3461:
3441:
3411:
3381:
3373:
3275:
3235:
3195:
3140:
3060:
3005:
2962:
2907:
2782:
2772:
2747:
2703:
2654:
2646:
2606:
2593:
2420:
2370:
2325:
2310:
2035:
2031:
1815:
1811:
858:
850:
816:
808:
has some details on one sub-class of the phosphorus-based compounds.
724:
5978:
5575:
5570:
5565:
5386:
5021:
4873:
4749:
4675:
4490:
4480:
4300:
4055:
4045:
4005:
4000:
3990:
3955:
3905:
3900:
3805:
3637:
3583:
3559:
3315:
3245:
3105:
2842:
2762:
2731:
2689:
2578:
2076:
1877:
1873:
1005:
946:
838:
439:
1733:
5582:
5560:
5555:
5173:
4745:
4725:
4305:
4276:
4130:
4125:
4120:
4115:
4105:
4009:
3895:
3830:
3825:
3633:
3613:
3465:
3240:
3125:
2927:
2922:
2917:
2912:
2360:
2111:
896:
846:
798:
645:
successfully purified and crystallized acetylcholinesterase from
585:
466:
to return to its resting state after activation. For example, in
455:
411:
2226:
299:
116:
5937:
5707:
5602:
5535:
5428:
5026:
4934:
4335:
4155:
3965:
3750:
3341:
2902:
2553:
1790:
801:
790:
778:
615:
463:
435:
306:
123:
1617:
949:"Acetylcholinesterase inhibitors: pharmacology and toxicology"
5911:
5544:
5295:
5291:
4705:
2265:
763:
607:
599:
573:
531:
415:
5276:
5153:
5146:
5090:
5085:
2092:
5676:
2239:
1514:
3763:
1789:
1347:
1293:
1614:
1447:
FBR Resource Guide: Acetylcholinesterase-Amniotic Fluid
1015:
462:. These reactions are necessary to allow a cholinergic
4186:
3782:
3131:
Octatropine methylbromide (anisotropine methylbromide)
5967:
2183:
1465:
1119:
231:
Cartoon diagram of human butyrylcholinesterase. From
1234:
1641:
5164:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
4868:
1515:Mense S, Simons D, Hoheisel U, Quenzer B (2003).
1466:Harrington CT, Hafid NA, Waters KA (2022-05-06).
670:, through the use of genetically modified goats.
5991:
3321:Scopolamine butylbromide (hyoscine butylbromide)
1421:
3346:Tooltip Selective serotonin reuptake inhibitors
1343:
1341:
4681:Trimetaphan camsilate (trimethaphan camsylate)
1175:
959:(3). Bentham Science Publishers Ltd.: 315–35.
550:in contrast, producing the second oddity that
5692:
4854:
4822:Acetylcholine metabolism/transport modulators
3736:
3710:Acetylcholine metabolism/transport modulators
2212:
1775:
819:have an inhibitory effect on cholinesterase.
4817:Muscarinic acetylcholine receptor modulators
1338:
1235:Leuzinger W, Baker AL, Cauvin E (Feb 1968).
3705:Nicotinic acetylcholine receptor modulators
1574:Journal of Electromyography and Kinesiology
1169:
1120:Barash PG, Cullen BF, Stoelting RK (2006).
1029:
5699:
5685:
4861:
4847:
3743:
3729:
3281:3-Quinuclidinyl thiochromane-4-carboxylate
2244:Tooltip Muscarinic acetylcholine receptors
2219:
2205:
1782:
1768:
1287:
1228:
1070:
1000:
998:
996:
994:
992:
225:
3768:Tooltip Nicotinic acetylcholine receptors
1752:at the U.S. National Library of Medicine
1742:at the U.S. National Library of Medicine
1677:
1667:
1491:
1384:
1374:
1270:
1260:
1211:
1201:
1076:
1053:
972:
498:
4311:Candocuronium iodide (chandonium iodide)
1035:
1011:Dorland's Illustrated Medical Dictionary
673:
16:Esterase that lyses choline-based esters
5054:Ubiquitin carboxy-terminal hydrolase L1
1708:Department of Health and Human Services
989:
845:. Such compounds are used for killing
5992:
4191:Tooltip negative allosteric modulators
3787:Tooltip positive allosteric modulators
1920:Phenylethanolamine N-methyltransferase
1567:
1144:
5680:
5634:either deoxy- or ribo-
4842:
3724:
2200:
2182:
1763:
727:and other organophosphate poisoning.
32:acetylcholinesterase (Yt blood group)
5215:Protein serine/threonine phosphatase
1004:
868:
781:. The structural requirements are a
519:more quickly; the latter hydrolyses
503:The two types of cholinesterase are
450:neurotransmitters, such as breaking
5316:Cyclic nucleotide phosphodiesterase
5310:Clostridium perfringens alpha toxin
5111:Tartrate-resistant acid phosphatase
2063:Acetylserotonin O-methyltransferase
789:groups, a leaving group (such as a
770:). One counteracting medication is
13:
5159:Pyruvate dehydrogenase phosphatase
1403:"Nerve gas antidote made by goats"
1176:Leuzinger W, Baker AL (Feb 1967).
1091:10.1111/j.1365-2044.1980.tb03800.x
649:at Columbia University, New York.
14:
6031:
5059:4-hydroxybenzoyl-CoA thioesterase
4396:Dimethyltubocurarine (metocurine)
2943:Etybenzatropine (ethybenztropine)
2615:chlorphenamine (chlorpheniramine)
2599:Antihistamines (first-generation)
2376:Desmethylclozapine (norclozapine)
2228:Muscarinic acetylcholine receptor
1697:
849:in a range of products including
833:; as well as in the treatment of
5977:
3752:Nicotinic acetylcholine receptor
2058:Aralkylamine N-acetyltransferase
1424:Textbook of Medical Biochemistry
1422:Shinde R, Chatterjea MN (2005).
917:
903:
889:
875:
38:
5377:N-acetylglucosamine-6-sulfatase
5265:Sphingomyelin phosphodiesterase
4776:Meclofenoxate (centrophenoxine)
4101:Suxethonium (succinyldicholine)
4096:Suxamethonium (succinylcholine)
3664:Meclofenoxate (centrophenoxine)
3482:northiaden (desmethyldosulepin)
1635:
1608:
1561:
1533:10.1152/japplphysiol.00727.2002
1508:
1459:
1440:
1415:
1122:Handbook of Clinical Anesthesia
680:pseudocholinesterase deficiency
5186:Inositol-phosphate phosphatase
5049:Palmitoyl protein thioesterase
3121:N-Methyl-3-piperidyl benzilate
1138:
1113:
410:) catalyses the hydrolysis of
1:
5549:RNA-induced silencing complex
4812:Receptor/signaling modulators
4466:Hexamethonium (benzohexonium)
3700:Receptor/signaling modulators
3116:N-Ethyl-3-piperidyl benzilate
1940:Catechol-O-methyl transferase
1855:Histamine N-methyltransferase
1586:10.1016/j.jelekin.2003.09.018
931:
745:
487:membranes. The other type is
6015:Peripheral membrane proteins
5653:Serratia marcescens nuclease
5220:Dual-specificity phosphatase
5210:Protein tyrosine phosphatase
3556:cyamemazine (cyamepromazine)
2014:4-aminobutyrate transaminase
732:sudden infant death syndrome
636:
434:. Thus, it is either of two
7:
6005:Genes on human chromosome 3
6000:Genes on human chromosome 7
5706:
5130:Fructose 1,6-bisphosphatase
4546:Methorphan (racemethorphan)
3876:Bephenium hydroxynaphthoate
3370:Tetracyclic antidepressants
3261:Profenamine (ethopropazine)
2883:Dicycloverine (dicyclomine)
1568:Simons DG (February 2004).
1484:10.1016/j.ebiom.2022.104041
965:10.2174/1570159x11311030006
426:O = choline + a carboxylate
48:acetylcholinesterase. From
10:
6036:
3926:Dimethylphenylpiperazinium
3519:Tripitamine (tripitramine)
2743:Benzatropine (benztropine)
1014:, Elsevier, archived from
430:Several of these serve as
20:
5863:
5855:Michaelis–Menten kinetics
5827:
5796:
5765:
5714:
5633:
5521:
5473:
5459:
5437:
5419:
5405:
5385:
5367:Galactosamine-6 sulfatase
5324:
5228:
5067:
5035:
4923:6-phosphogluconolactonase
4885:
4804:
4718:
4179:
3775:
3761:
3692:
3606:
3422:Tricyclic antidepressants
2972:+beclometasone/formoterol
2549:3-Quinuclidinyl benzilate
2539:
2251:
2237:
2194:
2143:
2135:Choline acetyltransferase
2123:
2110:
2075:
2053:-amino acid decarboxylase
2026:
2002:
1982:
1969:
1928:
1915:Dopamine beta-hydroxylase
1910:-amino acid decarboxylase
1889:
1872:
1843:
1823:
1810:
1801:
953:Current Neuropharmacology
618:with one of its terminal
534:produces the oddity that
408:acylcholine acylhydrolase
382:
372:
367:
363:
346:
334:
329:
317:
305:
293:
281:
269:
261:
251:
246:
224:
217:
199:
189:
184:
180:
163:
151:
146:
134:
122:
110:
98:
86:
78:
68:
63:
37:
30:
5747:Diffusion-limited enzyme
5115:Purple acid phosphatases
4786:Phosphatidylethanolamine
3674:Phosphatidylethanolamine
1754:Medical Subject Headings
1744:Medical Subject Headings
1713:Movies at weizmann.ac.il
1036:Wang R, Tang XC (2005).
752:cholinesterase inhibitor
641:In 1968, Walo Leuzinger
614:syllables both refer to
515:: the former hydrolyses
21:Not to be confused with
4566:Morphanol (racemorphan)
4506:Laudexium (laudolissin)
3916:Desformylflustrabromine
2898:Diphemanil metilsulfate
2753:Benzilylcholine mustard
2700:Atypical antipsychotics
1994:Glutamate decarboxylase
1835:Histidine decarboxylase
1376:10.1073/pnas.0702756104
1316:10.1126/science.1678899
659:using protein from the
602:and found primarily in
591:Butyrylcholinesterase (
582:neuromuscular junctions
5540:Microprocessor complex
5179:Beta-propeller phytase
3544:Typical antipsychotics
3316:Scopolamine (hyoscine)
2991:Hexahydrosiladifenidol
2968:Glycopyrronium bromide
2185:Acetylcholine receptor
2044:Tryptophan hydroxylase
1731:Molecule of the Month
1669:10.1186/1476-069X-9-36
762:, and the nerve gases
719:BCHE can be used as a
710:abdominal wall defects
584:, and in other neural
565:Acetylcholinesterase (
499:Types and nomenclature
472:neuromuscular junction
5840:Eadie–Hofstee diagram
5773:Allosteric regulation
5475:Endodeoxyribonuclease
5372:Iduronate-2-sulfatase
5125:Glucose 6-phosphatase
4911:Butyrylcholinesterase
4771:Glycerophosphocholine
3659:Glycerophosphocholine
3462:dosulepin (dothiepin)
3266:Propantheline bromide
3141:Otenzepad (AF-DX 116)
2695:Atropine methonitrate
2163:Butyrylcholinesterase
2089:Nitric oxide synthase
1262:10.1073/pnas.59.2.620
1203:10.1073/pnas.57.2.446
699:myocardial infarction
674:Clinical significance
509:butyrylcholinesterase
489:butyrylcholinesterase
470:, acetylcholine at a
219:butyrylcholinesterase
5850:Lineweaver–Burk plot
5658:Micrococcal nuclease
5493:Deoxyribonuclease IV
5488:Deoxyribonuclease II
5421:Exodeoxyribonuclease
5081:Alkaline phosphatase
4906:Acetylcholinesterase
4766:Dimethylethanolamine
4631:Rapacuronium bromide
4611:Pipecuronium bromide
4451:Gantacurium chloride
4411:Dizocilpine (MK-801)
3996:MEM-63,908 (RG-3487)
3946:Ethoxysebacylcholine
3654:Dimethylethanolamine
3574:Umeclidinium bromide
3454:desmethyldesipramine
3171:Oxyphenonium bromide
2381:Ethoxysebacylcholine
2159:Acetylcholinesterase
1901:Tyrosine hydroxylase
1750:Pseudocholinesterase
1740:Acetylcholinesterase
1723:Acetylcholinesterase
1648:Environmental Health
661:Pacific electric ray
544:pseudocholinesterase
540:false cholinesterase
505:acetylcholinesterase
477:acetylcholinesterase
46:Pacific electric ray
23:Acetylcholinesterase
5513:UvrABC endonuclease
5483:Deoxyribonuclease I
5206:Protein phosphatase
5142:Protein phosphatase
4940:Bile salt-dependent
4928:PAF acetylhydrolase
4781:Phosphatidylcholine
4666:Threohydrobupropion
4651:Stercuronium iodide
4586:Pancuronium bromide
3669:Phosphatidylcholine
3331:Sofpironium bromide
3216:Pipenzolate bromide
3026:Ipratropium bromide
2828:Cimetropium bromide
1660:2010EnvHe...9...36A
1367:2007PNAS..10413603H
1308:1991Sci...253..872S
1253:1968PNAS...59..620L
1194:1967PNAS...57..446L
1148:Miller's Anesthesia
843:Alzheimer's disease
827:biochemical warfare
714:neural tube defects
556:true cholinesterase
548:true cholinesterase
5809:Enzyme superfamily
5742:Enzyme promiscuity
5646:Mung bean nuclease
5505:Restriction enzyme
5498:Restriction enzyme
4701:Vecuronium bromide
4641:Rocuronium bromide
4551:Methyllycaconitine
4476:Hydroxynorketamine
4371:Dextropropoxyphene
4356:Dehydronorketamine
4346:Dacuronium bromide
3402:Tiotropium bromide
3397:Timepidium bromide
3156:Oxitropium bromide
3111:Muscarinic toxin 7
2986:Hexahydrodifenidol
2933:Emepronium bromide
2584:Ambutonium bromide
2559:Aclidinium bromide
1452:2007-06-25 at the
1145:Miller RD (2005).
806:Lawesson's reagent
690:during a surgery.
468:muscle contraction
422:an acylcholine + H
406:; systematic name
5965:
5964:
5674:
5673:
5670:
5669:
5666:
5665:
5455:
5454:
5447:Oligonucleotidase
5392:deoxyribonuclease
5360:Steroid sulfatase
5235:Phosphodiesterase
4964:Hormone-sensitive
4836:
4835:
4830:
4829:
4791:Phosphorylcholine
4729:
4714:
4713:
4511:Levacetylmethadol
4391:Dihydrochandonium
4271:sodium thiopental
3941:Ethanol (alcohol)
3718:
3717:
3679:Phosphorylcholine
3617:
3602:
3601:
3539:Trospium chloride
3434:amitriptylinoxide
3407:Tiquizium bromide
3251:Prifinium bromide
3146:Otilonium bromide
3101:Methylscopolamine
3096:Methylhomatropine
2953:Fentonium bromide
2833:Clidinium bromide
2176:
2175:
2172:
2171:
2071:
2070:
2052:
2022:
2021:
1965:
1964:
1945:Monoamine oxidase
1909:
1868:
1867:
1795:neurotransmission
1433:978-93-5025-484-4
1162:978-0-443-06618-4
1131:978-0-7817-5745-4
1055:10.1159/000085387
869:Additional images
835:myasthenia gravis
785:atom bearing two
481:chemical synapses
432:neurotransmitters
396:
395:
392:
391:
213:
212:
209:
208:
6027:
5982:
5981:
5973:
5845:Hanes–Woolf plot
5788:Enzyme activator
5783:Enzyme inhibitor
5757:Enzyme catalysis
5701:
5694:
5687:
5678:
5677:
5523:Endoribonuclease
5509:
5503:
5471:
5470:
5417:
5416:
5403:
5402:
5103:Acid phosphatase
4984:Monoacylglycerol
4894:ester hydrolases
4863:
4856:
4849:
4840:
4839:
4723:
4661:Thiocolchicoside
4471:Hydroxybupropion
4366:Dextromethorphan
4238:Allopregnanolone
4192:
4188:
4091:Suberyldicholine
3801:6-Chloronicotine
3788:
3784:
3773:
3772:
3769:
3765:
3745:
3738:
3731:
3722:
3721:
3611:
3392:Tiemonium iodide
3347:
3343:
3211:Phenyltoloxamine
3166:Oxyphencyclimine
2667:phenyltoloxamine
2471:Suberyldicholine
2249:
2248:
2245:
2241:
2221:
2214:
2207:
2198:
2197:
2180:
2179:
2148:
2128:
2121:
2120:
2050:
2007:
1987:
1980:
1979:
1933:
1907:
1894:
1887:
1886:
1848:
1828:
1821:
1820:
1808:
1807:
1784:
1777:
1770:
1761:
1760:
1692:
1691:
1681:
1671:
1639:
1633:
1632:
1612:
1606:
1605:
1565:
1559:
1558:
1556:
1555:
1527:(6): 2494–2901.
1512:
1506:
1505:
1495:
1463:
1457:
1444:
1438:
1437:
1419:
1413:
1410:
1398:
1388:
1378:
1345:
1336:
1335:
1291:
1285:
1284:
1274:
1264:
1232:
1226:
1225:
1215:
1205:
1173:
1167:
1166:
1142:
1136:
1135:
1117:
1111:
1110:
1074:
1068:
1067:
1057:
1033:
1027:
1026:
1024:
1023:
1002:
987:
986:
976:
944:
921:
907:
893:
879:
857:pesticides, and
404:choline esterase
365:
364:
240:
229:
215:
214:
182:
181:
57:
42:
28:
27:
6035:
6034:
6030:
6029:
6028:
6026:
6025:
6024:
5990:
5989:
5988:
5976:
5968:
5966:
5961:
5873:Oxidoreductases
5859:
5835:Enzyme kinetics
5823:
5819:List of enzymes
5792:
5761:
5732:Catalytic triad
5710:
5705:
5675:
5662:
5629:
5517:
5507:
5501:
5464:
5451:
5439:Exoribonuclease
5433:
5410:
5394:
5390:
5381:
5355:Arylsulfatase L
5350:Arylsulfatase B
5345:Arylsulfatase A
5320:
5233:
5224:
5063:
5031:
4893:
4881:
4867:
4837:
4832:
4831:
4826:
4800:
4722:
4710:
4316:Chlorisondamine
4190:
4183:
4175:
3786:
3779:
3767:
3757:
3749:
3719:
3714:
3688:
3610:
3598:
3552:chlorprothixene
3509:Trihexyphenidyl
3345:
3326:Silahexacyclium
3206:Phenglutarimide
2868:Desfesoterodine
2848:Cyclobenzaprine
2639:diphenhydramine
2603:brompheniramine
2535:
2486:Thiopilocarpine
2243:
2233:
2225:
2190:
2177:
2168:
2144:
2139:
2124:
2106:
2067:
2018:
2003:
1998:
1983:
1961:
1929:
1924:
1890:
1864:
1860:Diamine oxidase
1844:
1839:
1824:
1797:
1788:
1700:
1695:
1640:
1636:
1613:
1609:
1566:
1562:
1553:
1551:
1513:
1509:
1464:
1460:
1454:Wayback Machine
1445:
1441:
1434:
1420:
1416:
1409:. 24 July 2007.
1401:
1361:(34): 13603–8.
1346:
1339:
1302:(5022): 872–9.
1292:
1288:
1233:
1229:
1174:
1170:
1163:
1143:
1139:
1132:
1118:
1114:
1075:
1071:
1034:
1030:
1021:
1019:
1003:
990:
945:
938:
934:
927:
922:
913:
908:
899:
894:
885:
880:
871:
855:organophosphate
813:benzodiazepines
804:. The entry on
748:
684:succinylcholine
676:
639:
631:succinylcholine
501:
425:
242:
232:
59:
49:
26:
17:
12:
11:
5:
6033:
6023:
6022:
6017:
6012:
6007:
6002:
5987:
5986:
5963:
5962:
5960:
5959:
5946:
5933:
5920:
5907:
5894:
5881:
5867:
5865:
5861:
5860:
5858:
5857:
5852:
5847:
5842:
5837:
5831:
5829:
5825:
5824:
5822:
5821:
5816:
5811:
5806:
5800:
5798:
5797:Classification
5794:
5793:
5791:
5790:
5785:
5780:
5775:
5769:
5767:
5763:
5762:
5760:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5718:
5716:
5712:
5711:
5704:
5703:
5696:
5689:
5681:
5672:
5671:
5668:
5667:
5664:
5663:
5661:
5660:
5655:
5650:
5649:
5648:
5637:
5635:
5631:
5630:
5628:
5627:
5622:
5621:
5620:
5615:
5610:
5605:
5595:
5590:
5585:
5580:
5579:
5578:
5573:
5568:
5563:
5553:
5552:
5551:
5542:
5527:
5525:
5519:
5518:
5516:
5515:
5510:
5495:
5490:
5485:
5479:
5477:
5468:
5457:
5456:
5453:
5452:
5450:
5449:
5443:
5441:
5435:
5434:
5432:
5431:
5425:
5423:
5414:
5400:
5383:
5382:
5380:
5379:
5374:
5369:
5364:
5363:
5362:
5357:
5352:
5347:
5334:
5332:
5322:
5321:
5319:
5318:
5313:
5303:
5298:
5289:
5284:
5279:
5274:
5273:
5272:
5262:
5261:
5260:
5255:
5245:
5239:
5237:
5226:
5225:
5223:
5222:
5217:
5212:
5203:
5202:
5201:
5183:
5182:
5181:
5171:
5166:
5161:
5156:
5151:
5150:
5149:
5139:
5138:
5137:
5127:
5122:
5117:
5100:
5099:
5098:
5093:
5088:
5077:
5075:
5065:
5064:
5062:
5061:
5056:
5051:
5045:
5043:
5033:
5032:
5030:
5029:
5024:
5018:
5017:
5016:
5015:
5010:
5005:
4994:
4993:
4992:
4991:
4989:Diacylglycerol
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4942:
4931:
4930:
4925:
4920:
4918:Pectinesterase
4915:
4914:
4913:
4908:
4901:Cholinesterase
4897:
4895:
4883:
4882:
4866:
4865:
4858:
4851:
4843:
4834:
4833:
4828:
4827:
4825:
4824:
4819:
4814:
4809:
4805:
4802:
4801:
4799:
4798:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4743:
4738:
4732:
4730:
4716:
4715:
4712:
4711:
4709:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4663:
4658:
4653:
4648:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4496:Kynurenic acid
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4290:κ-bungarotoxin
4286:α-bungarotoxin
4279:
4274:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4224:, many others)
4214:α-bungarotoxin
4207:
4202:
4196:
4194:
4177:
4176:
4174:
4173:
4168:
4163:
4158:
4153:
4148:
4146:Tribendimidine
4143:
4138:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4073:
4071:Sebacylcholine
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4013:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3888:
3886:Butyrylcholine
3883:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3792:
3790:
3770:
3759:
3758:
3748:
3747:
3740:
3733:
3725:
3716:
3715:
3713:
3712:
3707:
3702:
3697:
3693:
3690:
3689:
3687:
3686:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3631:
3626:
3620:
3618:
3604:
3603:
3600:
3599:
3597:
3596:
3591:
3586:
3581:
3571:
3548:chlorpromazine
3541:
3536:
3531:
3526:
3521:
3516:
3511:
3506:
3501:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3367:
3362:
3357:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3223:
3218:
3213:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3151:Oxapium iodide
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3091:Methylatropine
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3023:
3018:
3013:
3008:
3003:
2998:
2993:
2988:
2983:
2965:
2960:
2955:
2950:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2875:
2870:
2865:
2860:
2855:
2853:Cyclopentolate
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2697:
2692:
2687:
2682:
2631:dimenhydrinate
2627:cyproheptadine
2596:
2591:
2586:
2581:
2576:
2571:
2566:
2556:
2551:
2545:
2543:
2537:
2536:
2534:
2533:
2528:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2478:
2473:
2468:
2466:Sebacylcholine
2463:
2458:
2453:
2448:
2443:
2438:
2433:
2428:
2423:
2418:
2413:
2408:
2403:
2398:
2393:
2388:
2383:
2378:
2373:
2368:
2363:
2358:
2353:
2348:
2343:
2338:
2333:
2328:
2323:
2321:Butyrylcholine
2318:
2313:
2308:
2303:
2298:
2293:
2288:
2283:
2278:
2273:
2268:
2263:
2257:
2255:
2246:
2235:
2234:
2224:
2223:
2216:
2209:
2201:
2195:
2192:
2191:
2174:
2173:
2170:
2169:
2167:
2166:
2155:Cholinesterase
2151:
2149:
2141:
2140:
2138:
2137:
2131:
2129:
2118:
2108:
2107:
2105:
2104:
2085:
2083:
2073:
2072:
2069:
2068:
2066:
2065:
2060:
2055:
2046:
2040:
2038:
2024:
2023:
2020:
2019:
2017:
2016:
2010:
2008:
2000:
1999:
1997:
1996:
1990:
1988:
1977:
1967:
1966:
1963:
1962:
1960:
1959:
1958:
1957:
1952:
1942:
1936:
1934:
1926:
1925:
1923:
1922:
1917:
1912:
1903:
1897:
1895:
1884:
1870:
1869:
1866:
1865:
1863:
1862:
1857:
1851:
1849:
1841:
1840:
1838:
1837:
1831:
1829:
1818:
1805:
1799:
1798:
1787:
1786:
1779:
1772:
1764:
1758:
1757:
1747:
1737:
1734:Cholinesterase
1726:
1716:
1710:
1699:
1698:External links
1696:
1694:
1693:
1634:
1607:
1560:
1521:J Appl Physiol
1507:
1458:
1439:
1432:
1414:
1412:
1411:
1337:
1286:
1227:
1168:
1161:
1137:
1130:
1112:
1085:(2): 174–197.
1069:
1048:(1–2): 71–82.
1028:
988:
935:
933:
930:
929:
928:
925:Butyrylcholine
923:
916:
914:
909:
902:
900:
895:
888:
886:
881:
874:
870:
867:
747:
744:
740:trigger points
723:agent against
675:
672:
638:
635:
580:membranes, in
578:red blood cell
552:cholinesterase
536:cholinesterase
528:cholinesterase
523:more quickly.
521:butyrylcholine
500:
497:
485:red blood cell
428:
427:
423:
400:cholinesterase
394:
393:
390:
389:
384:
380:
379:
374:
370:
369:
361:
360:
350:
344:
343:
338:
332:
331:
327:
326:
321:
315:
314:
309:
303:
302:
297:
291:
290:
285:
279:
278:
273:
267:
266:
265:CHE1, CHE2, E1
263:
259:
258:
253:
249:
248:
244:
243:
230:
222:
221:
211:
210:
207:
206:
201:
197:
196:
191:
187:
186:
178:
177:
167:
161:
160:
155:
149:
148:
144:
143:
138:
132:
131:
126:
120:
119:
114:
108:
107:
102:
96:
95:
90:
84:
83:
80:
76:
75:
70:
66:
65:
61:
60:
43:
35:
34:
15:
9:
6:
4:
3:
2:
6032:
6021:
6018:
6016:
6013:
6011:
6010:Acetylcholine
6008:
6006:
6003:
6001:
5998:
5997:
5995:
5985:
5980:
5975:
5974:
5971:
5957:
5953:
5952:
5947:
5944:
5940:
5939:
5934:
5931:
5927:
5926:
5921:
5918:
5914:
5913:
5908:
5905:
5901:
5900:
5895:
5892:
5888:
5887:
5882:
5879:
5875:
5874:
5869:
5868:
5866:
5862:
5856:
5853:
5851:
5848:
5846:
5843:
5841:
5838:
5836:
5833:
5832:
5830:
5826:
5820:
5817:
5815:
5814:Enzyme family
5812:
5810:
5807:
5805:
5802:
5801:
5799:
5795:
5789:
5786:
5784:
5781:
5779:
5778:Cooperativity
5776:
5774:
5771:
5770:
5768:
5764:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5737:Oxyanion hole
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5719:
5717:
5713:
5709:
5702:
5697:
5695:
5690:
5688:
5683:
5682:
5679:
5659:
5656:
5654:
5651:
5647:
5644:
5643:
5642:
5639:
5638:
5636:
5632:
5626:
5623:
5619:
5616:
5614:
5611:
5609:
5606:
5604:
5601:
5600:
5599:
5596:
5594:
5591:
5589:
5586:
5584:
5581:
5577:
5574:
5572:
5569:
5567:
5564:
5562:
5559:
5558:
5557:
5554:
5550:
5546:
5543:
5541:
5537:
5534:
5533:
5532:
5529:
5528:
5526:
5524:
5520:
5514:
5511:
5506:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5480:
5478:
5476:
5472:
5469:
5467:
5462:
5458:
5448:
5445:
5444:
5442:
5440:
5436:
5430:
5427:
5426:
5424:
5422:
5418:
5415:
5413:
5408:
5404:
5401:
5398:
5393:
5388:
5384:
5378:
5375:
5373:
5370:
5368:
5365:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5342:
5341:
5340:
5339:arylsulfatase
5336:
5335:
5333:
5331:
5327:
5323:
5317:
5314:
5311:
5307:
5304:
5302:
5299:
5297:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5271:
5268:
5267:
5266:
5263:
5259:
5256:
5254:
5251:
5250:
5249:
5248:Phospholipase
5246:
5244:
5241:
5240:
5238:
5236:
5231:
5227:
5221:
5218:
5216:
5213:
5211:
5207:
5204:
5200:
5196:
5192:
5189:
5188:
5187:
5184:
5180:
5177:
5176:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5148:
5145:
5144:
5143:
5140:
5136:
5133:
5132:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5112:
5108:
5104:
5101:
5097:
5094:
5092:
5089:
5087:
5084:
5083:
5082:
5079:
5078:
5076:
5074:
5070:
5066:
5060:
5057:
5055:
5052:
5050:
5047:
5046:
5044:
5042:
5038:
5034:
5028:
5025:
5023:
5020:
5019:
5014:
5011:
5009:
5006:
5004:
5001:
5000:
4999:
4998:Phospholipase
4996:
4995:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4946:
4943:
4941:
4938:
4937:
4936:
4933:
4932:
4929:
4926:
4924:
4921:
4919:
4916:
4912:
4909:
4907:
4904:
4903:
4902:
4899:
4898:
4896:
4892:
4888:
4884:
4879:
4875:
4871:
4864:
4859:
4857:
4852:
4850:
4845:
4844:
4841:
4823:
4820:
4818:
4815:
4813:
4810:
4807:
4806:
4803:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4751:
4747:
4744:
4742:
4739:
4737:
4734:
4733:
4731:
4727:
4721:
4717:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4606:Phencyclidine
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4576:Nitrous oxide
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4516:Levomethadone
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4461:Hexafluronium
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4351:Decamethonium
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4321:Cisatracurium
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4291:
4287:
4283:
4282:Bungarotoxins
4280:
4278:
4275:
4272:
4268:
4267:pentobarbital
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4223:
4219:
4215:
4211:
4210:α-Neurotoxins
4208:
4206:
4203:
4201:
4198:
4197:
4195:
4189:
4182:
4178:
4172:
4169:
4167:
4164:
4162:
4159:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4011:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3911:Decamethonium
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3846:Acetylcholine
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3793:
3791:
3785:
3778:
3774:
3771:
3766:
3760:
3756:
3753:
3746:
3741:
3739:
3734:
3732:
3727:
3726:
3723:
3711:
3708:
3706:
3703:
3701:
3698:
3695:
3694:
3691:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3639:
3635:
3632:
3630:
3627:
3625:
3622:
3621:
3619:
3615:
3609:
3605:
3595:
3592:
3590:
3587:
3585:
3582:
3579:
3575:
3572:
3569:
3565:
3561:
3557:
3553:
3549:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3504:Tridihexethyl
3502:
3499:
3495:
3491:
3490:protriptyline
3487:
3486:nortriptyline
3483:
3479:
3478:nitroxazepine
3475:
3471:
3467:
3463:
3459:
3455:
3451:
3447:
3443:
3439:
3435:
3431:
3430:+perphenazine
3427:
3426:amitriptyline
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3387:
3383:
3379:
3375:
3371:
3368:
3366:
3363:
3361:
3358:
3355:
3351:
3344:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3086:Methoctramine
3084:
3082:
3081:Methantheline
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3056:Mamba toxin 7
3054:
3052:
3051:Mamba toxin 3
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3031:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2981:
2977:
2973:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2949:
2948:Fenpiverinium
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2733:
2729:
2725:
2721:
2717:
2713:
2709:
2705:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2683:
2680:
2676:
2672:
2668:
2664:
2660:
2656:
2652:
2648:
2644:
2640:
2636:
2632:
2628:
2624:
2620:
2616:
2612:
2608:
2604:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2570:
2567:
2564:
2560:
2557:
2555:
2552:
2550:
2547:
2546:
2544:
2542:
2538:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2382:
2379:
2377:
2374:
2372:
2369:
2367:
2366:cis-Dioxolane
2364:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2342:
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2284:
2282:
2281:Acetylcholine
2279:
2277:
2274:
2272:
2269:
2267:
2264:
2262:
2259:
2258:
2256:
2254:
2250:
2247:
2242:
2236:
2232:
2229:
2222:
2217:
2215:
2210:
2208:
2203:
2202:
2199:
2193:
2189:
2186:
2181:
2164:
2160:
2156:
2153:
2152:
2150:
2147:
2142:
2136:
2133:
2132:
2130:
2127:
2122:
2119:
2117:
2116:Acetylcholine
2113:
2109:
2102:
2098:
2094:
2090:
2087:
2086:
2084:
2082:
2078:
2074:
2064:
2061:
2059:
2056:
2054:
2047:
2045:
2042:
2041:
2039:
2037:
2033:
2029:
2025:
2015:
2012:
2011:
2009:
2006:
2001:
1995:
1992:
1991:
1989:
1986:
1981:
1978:
1976:
1972:
1968:
1956:
1953:
1951:
1948:
1947:
1946:
1943:
1941:
1938:
1937:
1935:
1932:
1927:
1921:
1918:
1916:
1913:
1911:
1904:
1902:
1899:
1898:
1896:
1893:
1888:
1885:
1883:
1879:
1875:
1871:
1861:
1858:
1856:
1853:
1852:
1850:
1847:
1842:
1836:
1833:
1832:
1830:
1827:
1822:
1819:
1817:
1813:
1809:
1806:
1804:
1800:
1796:
1792:
1785:
1780:
1778:
1773:
1771:
1766:
1765:
1762:
1755:
1751:
1748:
1745:
1741:
1738:
1736:
1735:
1730:
1727:
1725:
1724:
1721:
1717:
1714:
1711:
1709:
1705:
1702:
1701:
1689:
1685:
1680:
1675:
1670:
1665:
1661:
1657:
1653:
1649:
1645:
1638:
1630:
1626:
1623:(2): 367–70.
1622:
1618:
1611:
1603:
1599:
1595:
1591:
1587:
1583:
1580:(1): 95–107.
1579:
1575:
1571:
1564:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1522:
1518:
1511:
1503:
1499:
1494:
1489:
1485:
1481:
1477:
1473:
1469:
1462:
1455:
1451:
1448:
1443:
1435:
1429:
1425:
1418:
1408:
1404:
1400:
1399:
1396:
1392:
1387:
1382:
1377:
1372:
1368:
1364:
1360:
1356:
1352:
1344:
1342:
1333:
1329:
1325:
1321:
1317:
1313:
1309:
1305:
1301:
1297:
1290:
1282:
1278:
1273:
1268:
1263:
1258:
1254:
1250:
1246:
1242:
1238:
1231:
1223:
1219:
1214:
1209:
1204:
1199:
1195:
1191:
1188:(2): 446–51.
1187:
1183:
1179:
1172:
1164:
1158:
1154:
1150:
1149:
1141:
1133:
1127:
1123:
1116:
1108:
1104:
1100:
1096:
1092:
1088:
1084:
1080:
1073:
1065:
1061:
1056:
1051:
1047:
1043:
1042:Neuro-Signals
1039:
1032:
1018:on 2014-01-11
1017:
1013:
1012:
1007:
1001:
999:
997:
995:
993:
984:
980:
975:
970:
966:
962:
958:
954:
950:
943:
941:
936:
926:
920:
915:
912:
906:
901:
898:
892:
887:
884:
883:Acetylcholine
878:
873:
872:
866:
864:
863:birth defects
860:
856:
852:
848:
844:
840:
836:
832:
828:
823:
820:
818:
814:
809:
807:
803:
800:
796:
792:
788:
784:
780:
775:
773:
769:
765:
761:
757:
753:
743:
741:
735:
733:
728:
726:
722:
717:
715:
711:
707:
706:amniocentesis
702:
700:
695:
691:
689:
685:
681:
671:
669:
664:
662:
658:
655:
650:
648:
647:electric eels
644:
634:
632:
628:
627:liver disease
623:
622:substituted.
621:
620:methyl groups
617:
613:
609:
605:
601:
597:
594:
589:
587:
583:
579:
575:
571:
568:
563:
561:
557:
553:
549:
545:
541:
537:
533:
529:
524:
522:
518:
517:acetylcholine
514:
510:
506:
496:
494:
490:
486:
482:
478:
473:
469:
465:
461:
457:
453:
452:acetylcholine
449:
445:
441:
437:
433:
421:
420:
419:
417:
413:
409:
405:
402:(EC 3.1.1.8,
401:
388:
385:
381:
378:
375:
371:
366:
362:
359:
358:
354:
351:
349:
345:
342:
339:
337:
333:
328:
325:
322:
320:
316:
313:
310:
308:
304:
301:
298:
296:
292:
289:
286:
284:
280:
277:
274:
272:
268:
264:
260:
257:
254:
250:
245:
239:
235:
228:
223:
220:
216:
205:
202:
198:
195:
192:
188:
183:
179:
176:
175:
171:
168:
166:
162:
159:
156:
154:
150:
145:
142:
139:
137:
133:
130:
127:
125:
121:
118:
115:
113:
109:
106:
103:
101:
97:
94:
91:
89:
85:
81:
77:
74:
71:
67:
62:
56:
52:
47:
41:
36:
33:
29:
24:
19:
5951:Translocases
5948:
5935:
5922:
5909:
5896:
5886:Transferases
5883:
5870:
5727:Binding site
5508:}}
5502:{{
5466:Endonuclease
5397:ribonuclease
5337:
5120:Nucleotidase
5041:Thioesterase
4900:
4691:Tubocurarine
4621:Promegestone
4616:Progesterone
4531:Mecamylamine
4341:Cyclopropane
4331:Coronaridine
4263:Barbiturates
4248:Anatruxonium
4218:α-cobratoxin
4061:Sazetidine A
3981:JNJ-39393406
3971:Ispronicline
3568:thioridazine
3564:mesoridazine
3498:trimipramine
3494:quinupramine
3446:clomipramine
3438:butriptyline
3256:Procyclidine
3221:Piperidolate
3136:Orphenadrine
3036:Isopropamide
3021:Imidafenacin
2980:+neostigmine
2976:+indacaterol
2958:Fesoterodine
2888:Dihexyverine
2838:Cloperastine
2708:fluperlapine
2679:triprolidine
2675:propiomazine
2671:promethazine
2659:phenindamine
2476:Talsaclidine
2436:Oxotremorine
2411:Methacholine
2401:LY-2,033,298
2154:
2145:
2125:
2004:
1984:
1930:
1891:
1845:
1825:
1793:involved in
1732:
1718:
1651:
1647:
1637:
1620:
1616:
1610:
1577:
1573:
1563:
1552:. Retrieved
1524:
1520:
1510:
1475:
1472:eBioMedicine
1471:
1461:
1442:
1423:
1417:
1406:
1358:
1354:
1299:
1295:
1289:
1247:(2): 620–3.
1244:
1240:
1230:
1185:
1181:
1171:
1147:
1140:
1121:
1115:
1082:
1078:
1072:
1045:
1041:
1031:
1020:, retrieved
1016:the original
1010:
956:
952:
824:
821:
810:
776:
760:snake venoms
749:
736:
729:
721:prophylactic
718:
703:
696:
692:
677:
665:
656:
654:Joel Sussman
651:
642:
640:
624:
604:blood plasma
590:
564:
555:
551:
547:
543:
539:
535:
527:
525:
502:
493:blood plasma
429:
407:
403:
399:
397:
355:
262:Alt. symbols
172:
79:Alt. symbols
18:
5722:Active site
5641:Nuclease S1
5412:Exonuclease
5306:Lecithinase
5135:Calcineurin
5073:Phosphatase
4979:Lipoprotein
4969:Endothelial
4796:Pirisudanol
4761:Cyprodenate
4741:Adafenoxate
4656:Surugatoxin
4646:Sevoflurane
4601:Pentolinium
4581:Norketamine
4501:Laudanosine
4431:Erythravine
4421:Encenicline
4406:Dipyrandium
4376:Dextrorphan
4222:α-conotoxin
4181:Antagonists
4166:WAY-317,538
4161:Varenicline
4151:Tropisetron
4141:Tebanicline
4086:SSR-180,711
4051:Rivanicline
4041:Pozanicline
4036:PNU-282,987
4031:PNU-120,596
4026:PHA-709,829
4021:PHA-543,613
3961:Galantamine
3936:Epiboxidine
3931:Epibatidine
3851:Altinicline
3684:Pirisudanol
3649:Cyprodenate
3629:Adafenoxate
3594:Zamifenacin
3578:+vilanterol
3534:Tropicamide
3529:Tropatepine
3514:Trimebutine
3474:lofepramine
3450:desipramine
3417:Tolterodine
3386:mirtazapine
3378:maprotiline
3360:Telenzepine
3336:Solifenacin
3311:SCH-217,443
3286:Revefenacin
3271:Propiverine
3231:Piroheptine
3226:Pirenzepine
3191:Penthienate
3076:Mepenzolate
3071:Meladrazine
3046:Hyoscyamine
3030:+salbutamol
3016:Homatropine
3001:Hexocyclium
2858:Darifenacin
2818:CAR-302,668
2813:CAR-302,537
2808:CAR-302,368
2803:CAR-302,282
2798:CAR-302,196
2793:CAR-301,060
2788:CAR-226,086
2758:Benzydamine
2738:Benactyzine
2716:+fluoxetine
2663:pheniramine
2651:mequitazine
2635:dimetindene
2619:cinnarizine
2589:Anisodamine
2563:+formoterol
2541:Antagonists
2521:WAY-132,983
2491:Vedaclidine
2461:SDZ 210-086
2456:Sabcomeline
2446:Pilocarpine
2316:Bethanechol
2146:catabolism:
2005:catabolism:
1931:catabolism:
1882:epinephrine
1846:catabolism:
1720:Proteopedia
1079:Anaesthesia
911:Acetic acid
825:Outside of
795:thiocyanate
772:pralidoxime
756:neurotoxins
668:PharmAthene
507:(ACHE) and
460:acetic acid
448:cholinergic
398:The enzyme
377:Swiss-model
247:Identifiers
194:Swiss-model
64:Identifiers
44:Diagram of
5994:Categories
5925:Isomerases
5899:Hydrolases
5766:Regulation
4954:Pancreatic
4891:Carboxylic
4756:Citicoline
4736:Acetyl-coA
4720:Precursors
4696:Vanoxerine
4686:Tropeinium
4671:Toxiferine
4636:Reboxetine
4626:Radafaxine
4571:Neramexane
4561:Mivacurium
4556:Metocurine
4521:Malouetine
4486:Isoflurane
4441:Fazadinium
4436:Esketamine
4416:Doxacurium
4401:Dioscorine
4361:Desflurane
4326:Coclaurine
4258:Atracurium
4243:Amantadine
4233:Alcuronium
3986:Levamisole
3976:Ivermectin
3921:Dianicline
3881:Butinoline
3866:Anatoxin-a
3755:modulators
3644:Citicoline
3624:Acetyl-coA
3608:Precursors
3589:Xanomeline
3470:imipramine
3458:dibenzepin
3365:Terodiline
3354:paroxetine
3350:femoxetine
3306:SCH-72,788
3301:SCH-57,790
3291:Rociverine
3186:PD-0298029
3181:PD-102,807
3161:Oxybutynin
3066:Mebeverine
3011:HL-031,120
2996:Hexbutinol
2938:Etanautine
2893:Difemerine
2873:Dexetimide
2823:Caramiphen
2778:Bornaprine
2728:tenilapine
2724:quetiapine
2712:olanzapine
2643:doxylamine
2623:clemastine
2611:captodiame
2569:Abediterol
2526:Xanomeline
2516:VU-0238429
2511:VU-0152100
2506:VU-0152099
2501:VU-0090157
2496:VU-0029767
2481:Tazomeline
2441:PD-151,832
2431:Ocvimeline
2416:Milameline
2391:LY-593,039
2356:Cevimeline
2301:Alvameline
2276:Aceclidine
2271:AC-260,584
2261:77-LH-28-1
2231:modulators
2188:modulators
2126:anabolism:
2028:tryptophan
1985:anabolism:
1892:anabolism:
1826:anabolism:
1554:2023-09-24
1022:2015-09-24
932:References
831:anesthesia
787:lipophilic
783:phosphorus
746:Inhibitors
688:mivacurium
513:substrates
444:hydrolysis
373:Structures
368:Search for
357:q26.1-26.2
330:Other data
190:Structures
185:Search for
147:Other data
5804:EC number
5531:RNase III
5389:(includes
5330:Sulfatase
5243:Autotaxin
5107:Prostatic
4959:Lysosomal
4874:esterases
4870:Hydrolase
4596:Pentamine
4591:Pempidine
4541:Methadone
4536:Memantine
4456:Halothane
4446:Gallamine
4426:Enflurane
4381:Diadonium
4296:Bupropion
4081:SIB-1553A
4076:SIB-1508Y
4066:SB-206553
3891:Carbachol
3871:AR-R17779
3861:Anatabine
3856:Anabasine
3821:A-867,744
3816:A-582,941
3811:A-366,833
3524:Tropacine
3442:cidoxepin
3412:Tofenacin
3382:mianserin
3374:amoxapine
3296:RU-47,213
3276:Quinidine
3236:Pizotifen
3196:Pethidine
3061:Mazaticol
3041:J-104,129
3006:Himbacine
2963:Flavoxate
2908:Drofenine
2783:Camylofin
2773:Biperiden
2748:Benzilone
2704:clozapine
2685:AQ-RA 741
2655:perlapine
2647:meclizine
2607:buclizine
2594:Anisodine
2579:AF-DX 384
2574:AF-DX 250
2421:Muscarine
2396:L-689,660
2386:Itameline
2371:Clozapine
2326:Carbachol
2311:Arecoline
2049:Aromatic
2036:melatonin
2032:serotonin
1971:glutamate
1906:Aromatic
1816:histamine
1812:histidine
1803:monoamine
1654:(1): 36.
1594:1050-6411
859:carbamate
851:sheep dip
817:temazepam
797:), and a
725:nerve gas
637:Discovery
526:The term
446:of these
336:EC number
312:NM_000055
271:NCBI gene
153:EC number
129:NM_015831
88:NCBI gene
6020:EC 3.1.1
5828:Kinetics
5752:Cofactor
5715:Activity
5625:RNase T1
5387:Nuclease
5022:Cutinase
4808:See also
4750:lecithin
4726:prodrugs
4676:Tramadol
4526:ME-18-MC
4491:Ketamine
4481:Ibogaine
4301:BW284C51
4056:RJR-2429
4046:Pyrantel
4006:Nicotine
4001:Morantel
3991:Lobeline
3956:EVP-6124
3951:EVP-4473
3906:Cytisine
3901:Cotinine
3806:A-84,543
3777:Agonists
3696:See also
3638:lecithin
3614:prodrugs
3584:WIN-2299
3560:loxapine
3246:Pridinol
3106:Metixene
2863:DAU-5884
2843:CS-27349
2763:Bevonium
2732:zotepine
2720:rilapine
2690:Atropine
2351:CDD-0102
2346:CDD-0098
2341:CDD-0097
2336:CDD-0078
2331:CDD-0034
2306:AQRA-741
2291:AF150(S)
2253:Agonists
2077:arginine
1878:dopamine
1874:tyrosine
1688:20618979
1602:14759755
1541:12576409
1502:35533499
1450:Archived
1407:BBC News
1395:17660298
1332:28833513
1222:16591490
1107:32806785
1064:15956816
1006:Elsevier
983:24179466
839:glaucoma
815:, e.g.,
799:terminal
586:synapses
440:catalyze
387:InterPro
241:.
204:InterPro
58:.
5984:Biology
5938:Ligases
5708:Enzymes
5598:RNase E
5593:RNase Z
5588:RNase A
5583:RNase P
5556:RNase H
5174:Phytase
4974:Hepatic
4949:Lingual
4945:Gastric
4746:Choline
4306:BW-A444
4284:(e.g.,
4277:BNC-210
4265:(e.g.,
4228:ABT-126
4212:(e.g.,
4171:XY-4083
4136:TC-6683
4131:TC-5619
4126:TC-5214
4121:TC-2216
4116:TC-1827
4111:TC-1734
4106:TC-1698
4016:NS-1738
4010:tobacco
3896:Choline
3841:ABT-894
3836:ABT-560
3831:ABT-418
3826:ABT-202
3634:Choline
3546:(e.g.,
3466:doxepin
3424:(e.g.,
3372:(e.g.,
3348:(e.g.,
3241:Poldine
3201:pFHHSiD
3126:Nefopam
2928:EA-3834
2923:EA-3580
2918:EA-3443
2913:EA-3167
2768:BIBN 99
2702:(e.g.,
2601:(e.g.,
2426:NGX-267
2406:McNA343
2361:Choline
2112:choline
1791:Enzymes
1679:2911418
1656:Bibcode
1549:1829156
1493:9092508
1386:1934339
1363:Bibcode
1324:1678899
1304:Bibcode
1296:Science
1281:5238989
1249:Bibcode
1190:Bibcode
1099:6992635
974:3648782
897:Choline
847:insects
612:butyryl
596:3.1.1.8
570:3.1.1.7
456:choline
436:enzymes
414:-based
412:choline
383:Domains
341:3.1.1.8
319:UniProt
200:Domains
158:3.1.1.7
136:UniProt
5970:Portal
5912:Lyases
5536:Drosha
5461:3.1.21
5429:RecBCD
5407:3.1.11
5027:PETase
4935:Lipase
4336:Curare
4253:AQW051
4200:18-MAC
4156:UB-165
3966:GTS-21
3796:5-HIAA
3764:nAChRs
2903:Ditran
2554:4-DAMP
2531:YM-796
2296:AF267B
2240:mAChRs
1756:(MeSH)
1746:(MeSH)
1686:
1676:
1627:
1600:
1592:
1547:
1539:
1500:
1490:
1430:
1393:
1383:
1330:
1322:
1279:
1272:224717
1269:
1220:
1213:335526
1210:
1159:
1128:
1105:
1097:
1062:
981:
971:
841:, and
802:oxygen
791:halide
779:enzyme
657:et al.
643:et al.
616:butane
606:. The
464:neuron
416:esters
353:Chr. 3
324:P06276
307:RefSeq
300:177400
252:Symbol
170:Chr. 7
141:P22303
124:RefSeq
117:100740
69:Symbol
5864:Types
5545:Dicer
5500:;see
5326:3.1.6
5296:PDE4B
5292:PDE4A
5230:3.1.4
5199:IMPA3
5195:IMPA2
5191:IMPA1
5069:3.1.3
5037:3.1.2
4887:3.1.1
4724:(and
4706:Xenon
4205:18-MC
4184:(and
3780:(and
3612:(and
3342:SSRIs
2266:AC-42
1706:U.S.
1629:29327
1545:S2CID
1328:S2CID
1153:487–8
1103:S2CID
811:Some
764:sarin
608:butyl
600:liver
574:blood
532:usage
454:into
438:that
348:Locus
165:Locus
5956:list
5949:EC7
5943:list
5936:EC6
5930:list
5923:EC5
5917:list
5910:EC4
5904:list
5897:EC3
5891:list
5884:EC2
5878:list
5871:EC1
5463:-31:
5409:-16:
5395:and
5301:PDE5
5287:PDE3
5282:PDE2
5277:PDE1
5169:PTEN
5154:OCRL
5147:PP2A
5096:ALPP
5091:ALPL
5086:ALPI
4880:3.1)
4386:DHβE
4187:NAMs
3783:PAMs
3176:PBID
2878:DIBD
2451:RS86
2286:AF30
2101:NOS3
2097:NOS2
2093:NOS1
1975:GABA
1684:PMID
1625:PMID
1598:PMID
1590:ISSN
1537:PMID
1498:PMID
1428:ISBN
1391:PMID
1320:PMID
1277:PMID
1218:PMID
1157:ISBN
1126:ISBN
1095:PMID
1060:PMID
979:PMID
766:and
712:and
610:and
560:HGNC
554:and
538:and
483:and
458:and
442:the
295:OMIM
283:HGNC
256:BCHE
238:1P0I
112:OMIM
100:HGNC
73:ACHE
55:1EA5
5618:4/5
3432:),
2718:),
1729:PDB
1674:PMC
1664:doi
1582:doi
1529:doi
1488:PMC
1480:doi
1381:PMC
1371:doi
1359:104
1312:doi
1300:253
1267:PMC
1257:doi
1208:PMC
1198:doi
1087:doi
1050:doi
969:PMC
961:doi
793:or
686:or
576:on
288:983
276:590
234:PDB
174:q22
105:108
51:PDB
5996::
5576:2C
5571:2B
5566:2A
5547::
5538::
5328::
5208::
5197:,
5193:,
5109:)/
5071::
5039::
5008:A2
5003:A1
4889::
4878:EC
4872::
4288:,
4269:,
4220:,
4216:,
3566:,
3562:,
3558:,
3554:,
3550:,
3496:,
3492:,
3488:,
3484:,
3480:,
3476:,
3472:,
3468:,
3464:,
3460:,
3456:,
3452:,
3448:,
3444:,
3440:,
3436:,
3384:,
3380:,
3376:,
3352:,
2978:,
2974:,
2730:,
2726:,
2722:,
2710:,
2706:,
2677:,
2673:,
2669:,
2665:,
2661:,
2657:,
2653:,
2649:,
2645:,
2641:,
2637:,
2633:,
2629:,
2625:,
2621:,
2617:,
2613:,
2609:,
2605:,
2161:,
2099:,
2095:,
2081:NO
1814:→
1682:.
1672:.
1662:.
1650:.
1646:.
1621:21
1619:.
1596:.
1588:.
1578:14
1576:.
1572:.
1543:.
1535:.
1525:94
1523:.
1519:.
1496:.
1486:.
1478:.
1476:80
1474:.
1470:.
1405:.
1389:.
1379:.
1369:.
1357:.
1353:.
1340:^
1326:.
1318:.
1310:.
1298:.
1275:.
1265:.
1255:.
1245:59
1243:.
1239:.
1216:.
1206:.
1196:.
1186:57
1184:.
1180:.
1155:.
1101:.
1093:.
1083:35
1081:.
1058:.
1046:14
1044:.
1040:.
1008:,
991:^
977:.
967:.
957:11
955:.
951:.
939:^
865:.
853:,
837:,
768:VX
750:A
742:.
734:.
716:.
701:.
663:.
633:.
593:EC
567:EC
495:.
418::
236::
93:43
82:YT
53::
5972::
5958:)
5954:(
5945:)
5941:(
5932:)
5928:(
5919:)
5915:(
5906:)
5902:(
5893:)
5889:(
5880:)
5876:(
5700:e
5693:t
5686:v
5613:3
5608:2
5603:1
5561:1
5399:)
5312:)
5308:(
5294:/
5270:1
5258:D
5253:C
5232::
5113:/
5105:(
5013:B
4947:/
4876:(
4862:e
4855:t
4848:v
4752:)
4748:(
4728:)
4292:)
4273:)
4193:)
4012:)
4008:(
3789:)
3744:e
3737:t
3730:v
3640:)
3636:(
3616:)
3580:)
3576:(
3570:)
3500:)
3428:(
3388:)
3356:)
3032:)
3028:(
2982:)
2970:(
2734:)
2714:(
2681:)
2565:)
2561:(
2220:e
2213:t
2206:v
2165:)
2157:(
2114:→
2103:)
2091:(
2079:→
2051:L
2034:→
2030:→
1973:→
1955:B
1950:A
1908:L
1880:→
1876:→
1783:e
1776:t
1769:v
1690:.
1666::
1658::
1652:9
1631:.
1604:.
1584::
1557:.
1531::
1504:.
1482::
1436:.
1397:.
1373::
1365::
1334:.
1314::
1306::
1283:.
1259::
1251::
1224:.
1200::
1192::
1165:.
1134:.
1109:.
1089::
1066:.
1052::
1025:.
985:.
963::
542:(
424:2
25:.
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