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in 1963. Solid-phase synthesis routes enable manufacturing of relatively long peptide sequences by avoiding isolation and purification of synthetic intermediates. This iterative process allows for the preparation of more complex peptides for use as active pharmaceutical ingredients (APIs), novel drug
575:
Vanderpool, Darin; Johnson, Ted O.; Ping, Chen; Bergqvist, Simon; Alton, Gordon; Phonephaly, Soneprasith; Rui, Eugene; Luo, Chun; Deng, Ya-Li; Grant, Stephan; Quenzer, Terri; Margosiak, Steve; Register, James; Brown, Ed; Ermolieff, Jacques (2009). "Vanderpool, Darin, et al. "Characterization of the
375:
Phillips, Chris; Roberts, Lee R.; Schade, Markus; Bazin, Richard; Bent, Andrew; Davies, Nichola L.; Moore, Rob; Pannifer, Andrew D.; Pickford, Andrew R.; Prior, Stephen H.; Read, Christopher M.; Scott, Andrew; Brown, David G.; Xu, Bin; Irving, Stephen L. (2011). "Design and
Structure of Stapled
411:
Zhang, Hongtao; Curreli, Francesca; Waheed, Abdul A.; Mercredi, Peter Y.; Mehta, Mansi; Bhargava, Pallavi; Scacalossi, Daniel; Tong, Xiaohe; Lee, Shawn; Cooper, Alan; Summers, Michael F.; Freed, Eric O.; Debnath, Asim K. (2013).
464:"Sharma, Rajesh K., et al. "Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors." Cancer research 69.10 (2009): 4319-4326"
195:, CPC Scientific was founded in 2001 by Dr. Shawn Lee, Ph.D. Product lines initially included research-grade custom peptides, catalog peptides, and Fmoc-protected amino acids. In 2006, CPC Scientific opened a GMP (
49:
479:"Mentinova, Marija, and Scott A. McLuckey. "Covalent modification of gaseous peptide ions with N-hydroxysuccinimide ester reagent ions." Journal of the American Chemical Society 132.51 (2010): 18248-18257"
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therapeutics, and general research applications. CPC Scientific has published some research articles that describe peptide synthesis methodologies, including a technique called hydrocarbon stapling.
326:
Capon, Daniel J.; Kaneko, Naoki; Yoshimori, Takayuki; Shimada, Takashi; Wurm, Florian M.; Hwang, Peter K.; Tong, Xiaohe; Adams, Staci A.; Simmons, Graham; Sato, Taka-Aki; Tanaka, Koichi (2011).
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207:(FDA) and the company began supplying pharmaceutical-grade peptides to companies in the United States. On March 17, 2016, CPC Scientific passed a fourth U.S. FDA inspection.
612:"Ardiani, Andressa, et al. "Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process." Cancer research 74.7 (2014): 1945-1957"
183:. The company provides a number of products and services to academic researchers and pharmaceutical industries, including research- and GMP-grade custom peptides.
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to stabilize alpha-helix and beta-sheet secondary structures. Products manufactured by CPC Scientific have also been cited in scientific journals.
328:"Capon, Daniel J., et al. "Flexible antibodies with nonprotein hinges." Proceedings of the Japan Academy, Series B 87.9 (2011): 603-616"
672:
528:"Sun, Tzu-Lin, et al. "Membrane permeability of hydrocarbon-cross-linked peptides." Biophysical Journal 104.9 (2013): 1923-1932"
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and began producing GMP-grade peptides for use in clinical applications. By 2011, the GMP facility was inspected by the U.S.
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Curreli, F.; Haque, K.; Xie, L.; Qiu, Q.; Xu, J.; Yong, W.; Tong, X.; Debnath, A. K. (2015).
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Shawn Lee (Chairman and
Founder), Irvine Skeoch (COO), Xiaohe Tong (Chief Technical Officer)
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CHK1 allosteric inhibitor binding site." Biochemistry 48.41 (2009): 9823-9830".
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Sun, Tzu-Lin; Sun, Yen; Lee, Chang-Chun; Huang, Huey W. (2013).
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CPC Scientific manufactures most of their products by way of
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Technology companies based in the San
Francisco Bay Area
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