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Beta blocker

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572:, representing the 51 largest orchestras in the United States, revealed 27% of its musicians had used beta blockers and 70% obtained them from friends, not physicians. Beta blockers are inexpensive, said to be relatively safe, and on one hand, seem to improve musicians' performances on a technical level, while some, such as Barry Green, the author of "The Inner Game of Music" and Don Greene, a former Olympic diving coach who teaches Juilliard students to overcome their stage fright naturally, say the performances may be perceived as "soulless and inauthentic". 588:. Starting them around the time of other types of surgery, however, may worsen outcomes. For non-cardiac surgery, the use of beta blockers to prevent adverse effects may reduce the risk of atrial fibrillation and myocardial infarctions (very low certainty evidence), however, there is moderate certainty evidence that this approach may increase the risk of hypotension. Low-certainty evidence suggests that beta blockers used perioperatively in non-cardiac surgeries may increase the risk of bradycardia. 1793: 7786: 7807: 51: 1006: 401:
arrhythmias such as atrial fibrillation and heart failure. They are also used in the management of other heart diseases, such as hypertrophic obstructive cardiomyopathy, mitral valve stenosis or prolapse, and dissecting aneurysm. Additionally, beta blockers find applications in vascular surgery, the treatment of anxiety states, cases of thyrotoxicosis, glaucoma, migraines, and esophageal varices.
1769:. It is thought that highly lipophilic beta blockers are able to readily cross into the brain, moderately lipophilic beta blockers are able to cross to a lesser degree, and low lipophilicity or hydrophilic beta blockers are minimally able to cross. More lipophilic beta-blockers are known to suppress melatonin release by 50-80%. The preceding beta blockers also vary in their 1304:
life-threatening arrhythmia in certain patients. By slowing the conduction through the AV node, preferential conduction through the accessory pathway is favored. If the patient happens to develop atrial flutter, this could lead to a 1:1 conduction with very fast ventricular rate, or worse, ventricular fibrillation in the case of atrial fibrillation.
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cardiac tissue remodeling, all of which decrease the efficiency of cardiac contraction and contribute to the low ejection fraction. Beta blockers counter this inappropriately high sympathetic activity, eventually leading to an improved ejection fraction, despite an initial reduction in ejection fraction.
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Accordingly, nonselective beta blockers are expected to have antihypertensive effects. The primary antihypertensive mechanism of beta blockers is unclear, but may involve reduction in cardiac output (due to negative chronotropic and inotropic effects). It may also be due to reduction in renin release
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actions, but have minimal effect on resting subjects. That is, they reduce the effect of excitement or physical exertion on heart rate and force of contraction, and also tremor, and breakdown of glycogen. Beta blockers can have a constricting effect on the bronchi of the lungs, possibly worsening or
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Also referred to as intrinsic sympathomimetic effect, this term is used particularly with beta blockers that can show both agonism and antagonism at a given beta receptor, depending on the concentration of the agent (beta blocker) and the concentration of the antagonized agent (usually an endogenous
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therapy in congestive heart failure, although at doses typically much lower than those indicated for other conditions. Beta blockers are only indicated in cases of compensated, stable congestive heart failure; in cases of acute decompensated heart failure, beta blockers will cause a further decrease
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A 2014 Cochrane review found that in individuals with mild-to-moderate hypertension, non-selective beta blockers led to a reduction of -10/-7mmHg (systolic/diastolic) without increased rates of adverse events. At higher doses, it was found to increase the rate of adverse effects such as a reduction
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van der Vring JA, Daniëls MC, Holwerda NJ, Withagen PJ, Schelling A, Cleophas TJ, Hendriks MG (June 1999). "Combination of calcium channel blockers and beta blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel
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Beta blockers are utilized in the treatment of various conditions related to the heart and vascular system, as well as several other medical conditions. Common heart-related conditions for which beta blockers are well-established include angina pectoris, acute coronary syndromes, hypertension, and
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Trials have shown beta blockers reduce the absolute risk of death by 4.5% over a 13-month period. In addition to reducing the risk of mortality, the numbers of hospital visits and hospitalizations were also reduced in the trials. A 2020 Cochrane review found minimal evidence to support the use of
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Some pre-clinical and clinical research suggests that some beta blockers may be beneficial for cancer treatment. However, other studies do not show a correlation between cancer survival and beta blocker usage. Also, a 2017 meta-analysis failed to show any benefit for the use of beta blockers in
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and beta blocker labetalol is especially useful for treatment of concomitant tachycardia and hypertension induced by methamphetamine. The phenomenon of "unopposed alpha stimulation" has not been reported with the use of beta blockers for treatment of methamphetamine toxicity. Other appropriate
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volume and increasing the oxygen-carrying capacity of the blood. Heart failure characteristically involves increased catecholamine activity on the heart, which is responsible for several deleterious effects, including increased oxygen demand, propagation of inflammatory mediators, and abnormal
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Unless a pacemaker is present, beta blockers can severely depress conduction in the AV node, resulting in a reduction of heart rate and cardiac output. One should be very cautious with the use of beta blockers in tachycardia patients with Wolff-Parkinson-White Syndrome, as it can result in
936:(angiotensin receptor blockers) actually decrease the risk of diabetes. Clinical guidelines in Great Britain, but not in the United States, call for avoiding diuretics and beta blockers as first-line treatment of hypertension due to the risk of diabetes. 518:
A 2017 Cochrane review on the use of beta blockers in hypertension found a modest reduction in cardiovascular disease but little to no change in mortality It suggested that the effects of beta blockers are inferior to other anti-hypertensive medications.
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Leizorovicz A, Lechat P, Cucherat M, Bugnard F (February 2002). "Bisoprolol for the treatment of chronic heart failure: a meta-analysis on individual data of two placebo-controlled studies—CIBIS and CIBIS II. Cardiac Insufficiency Bisoprolol Study".
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Livingstone E, Hollestein LM, van Herk-Sukel MP, van de Poll-Franse L, Nijsten T, Schadendorf D, de Vries E (December 2013). "β-Blocker use and all-cause mortality of melanoma patients: results from a population-based Dutch cohort study".
2854:"Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group" 437:
Beta blockers are known primarily for their reductive effect on heart rate, although this is not the only mechanism of action of importance in congestive heart failure. Beta blockers, in addition to their sympatholytic
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Morales DR, Jackson C, Lipworth BJ, Donnan PT, Guthrie B (April 2014). "Adverse respiratory effect of acute β-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials".
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Cardwell CR, Coleman HG, Murray LJ, O'Sullivan JM, Powe DG (June 2014). "Beta-blocker usage and prostate cancer survival: a nested case-control study in the UK Clinical Practice Research Datalink cohort".
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Agents with ISA should not be used for patients with any kind of angina as it can aggravate or after myocardial infarctions. They may also be less effective than other beta blockers in the management of
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Volz-Zang C, Eckrich B, Jahn P, Schneidrowski B, Schulte B, Palm D (1994). "Esmolol, an ultrashort-acting, selective beta 1-adrenoceptor antagonist: pharmacodynamic and pharmacokinetic properties".
3691:, Pucci, G., Ranalli, M. G., Battista, F., & Schillaci, G. (2015). Effects of β-Blockers With and Without Vasodilating Properties on Central Blood Pressure. Hypertension, HYPERTENSIONAHA-115. 413:, as they have the potential to worsen the condition due to their effect of decreasing cardiac contractility, studies in the late 1990s showed their efficacy at reducing morbidity and mortality. 3011: 721: 6004: 4268:
Richards JR, Albertson TE, Derlet RW, Lange RA, Olson KR, Horowitz BZ (May 2015). "Treatment of toxicity from amphetamines, related derivatives, and analogues: a systematic clinical review".
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Richards JR, Albertson TE, Derlet RW, Lange RA, Olson KR, Horowitz BZ (May 2015). "Treatment of toxicity from amphetamines, related derivatives, and analogues: a systematic clinical review".
913:-blockers have fewer metabolic side effects in diabetic patients; however, the fast heart rate that serves as a warning sign for insulin-induced low blood sugar may be masked, resulting in 5393: 472:
of target) with a gradual escalation of the dose. The heart of the patient must adjust to decreasing stimulation by catecholamines and find a new equilibrium at a lower adrenergic drive.
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receptors. By far the greatest effect of beta blockers remains in the heart. Newer, third-generation beta blockers can cause vasodilation through blockade of alpha-adrenergic receptors.
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response (pounding heart, cold/clammy hands, increased respiration, sweating, etc.) are significantly reduced, thus enabling anxious individuals to concentrate on the task at hand.
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beta-blockers, β-blockers, beta-adrenergic blocking agents, beta antagonists, beta-adrenergic antagonists, beta-adrenoreceptor antagonists, beta adrenergic receptor antagonists, BB
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A 2017 Cochrane review on the use of beta blockers to prevent aortic dissections in people with Marfan syndrome was unable to draw definitive conclusions due to lack of evidence.
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adrenergic receptors can cause vascular smooth muscle dilation, beta blockers may cause some vasoconstriction. However, this effect tends to be small because the activity of β
2931:"Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study" 488:. This results an increase in heart rate and blood pressure, therefore increasing myocardial oxygen demand. Beta blockers competitively inhibit catecholamines acting on the β 2516: 5974: 3947: 2346:"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)" 6397:
Boehm I, Morelli J, Nairz K, Silva Hasembank Keller P, Heverhagen JT (November 2016). "Beta blockers and intravenous roentgen contrast materials: Which risks do exist?".
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Richards JR, Hollander JE, Ramoska EA, Fareed FN, Sand IC, Izquierdo Gómez MM, Lange RA (May 2017). "β-Blockers, Cocaine, and the Unopposed α-Stimulation Phenomenon".
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properties of beta blockers allow the lifesaving property of heart rate control. Beta blockers are readily titrated to optimal rate control in many pathologic states.
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and cardiovascular mortality. The review identified that beta blockers likely had little to no impact on short-term all-cause mortality and cardiovascular mortality.
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receptor will inhibit cAMP from phosphorylating, and it will decrease the ionotrophic and chronotropic effect. Note that drugs may be cardioselective, or act on β
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and tissue perfusion by means of leaving the alpha-adrenergic system stimulation unopposed. Beta blockers with lipophilic properties and CNS penetration such as
868:-selective (often termed "cardioselective") agents, but receptor selectivity diminishes at higher doses. Beta blockade, especially of the beta-1 receptor at the 6359: 2206:
is the only agent indicated for the control of tremor, portal hypertension, and esophageal variceal bleeding, and used in conjunction with α-blocker therapy in
7738: 6818: 4647: 2241:. However, there is limited evidence supporting the efficacy of supplemental beta blocker use in addition to antipsychotic drugs for treating schizophrenia. 98: 334:(adrenaline). Beta blockers interfere with the binding to the receptor of epinephrine and other stress hormones and weaken the effects of stress hormones. 1237:) asthma guidelines recommend against the use of non-selective beta blockers in asthmatics, while allowing for the use of cardio selective beta blockers. 692:
Because they promote lower heart rates and reduce tremors, beta blockers have been used in professional sports where high accuracy is required, including
8408: 8908: 4601: 3003: 864:-adrenergic receptor antagonist activity (bronchospasm, peripheral vasoconstriction, alteration of glucose and lipid metabolism) are less common with β 6437:
by Gerald Klickstein, March 11, 2010 (A blog post that considers "whether beta-blockers are safe, effective, and appropriate for performers to use.")
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in comparison to other anti hypertensive medications. The review found no suitable evidence to support the current guidelines recommending its use.
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Zipursky JS, Macdonald EM, Luo J, Gomes T, Mamdani MM, Paterson JM, Juurlink DN (June 2017). "Lipophilic β-Blockers and Suicide in the Elderly".
5385: 6079:"Inhibition of β2-adrenergic receptor reduces triple-negative breast cancer brain metastases: The potential benefit of perioperative β-blockade" 9773: 9753: 8401: 6128:"Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice" 4377: 4120: 1705:
Most beta blockers are lipophilic and can cross into the brain, but there are a number of exceptions. Highly lipophilic beta blockers include
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Beta blockers must not be used in the treatment of selective alpha-adrenergic agonist overdose. The blockade of only beta receptors increases
7837: 8824: 7976: 4788: 4243: 3688: 6808: 4717: 1784:(or cardioselectivity), resulting in further differences in pharmacological profiles and suitability in different contexts between them. 1525:
Antianginal effects result from negative chronotropic and inotropic effects, which decrease cardiac workload and oxygen demand. Negative
4856: 7589: 2276: 857:, are more likely than other less lipophilic beta blockers to cause sleep disturbances, such as insomnia, vivid dreams and nightmares. 459:
beta blockers in congestive heart failure in children, however did identify that from the data available, that they may be of benefit.
7549: 10481: 9808: 9061: 4368: 5009: 4930: 4683: 4578: 2391: 11139: 7830: 2508: 492:-adrenergic receptors, thus reducing these detrimental effects and resulting in reduced myocardial oxygen consumption and demand. 8817: 6502: 6452: 5458: 4822: 1016: 5966: 5914: 5888: 4142:
Elliott WJ, Meyer PM (January 2007). "Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis".
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or no intervention, it found that beta blockers probably reduced the short-term risk of reinfarction and the long-term risk of
2469:"Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity" 621:
There are few non-cardiovascular uses for adrenergic antagonists. Alpha-adrenergic antagonists are also used for treatment of
11103: 8359: 7162: 6752: 6028:"Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients" 5646: 5055: 5021: 4982: 4942: 4906: 4868: 4832: 4798: 4729: 4693: 4659: 3712: 3541:"Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery" 2836: 2444: 2403: 1173: 5524: 5491: 7449: 7442: 1074: 580:
Low certainty evidence indicates that the use of beta blockers around the time of cardiac surgery may decrease the risk of
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Weinstein RS, Cole S, Knaster HB, Dahlbert T (February 1985). "Beta blocker overdose with propranolol and with atenolol".
1283:, and tremors. Diligent blood glucose level monitoring is necessary for a patient with diabetes mellitus on beta blocker. 684:
may be more favorable for such purposes due to the possibility of "unopposed α-stimulation" with selective beta blockers.
11130: 3489:"Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing cardiac surgery" 1046: 4312: 7192: 7055: 2971: 1908:-selective beta blockers are also known as cardioselective beta blockers. Pharmacologically, the beta-blockade of the β 1770: 933: 4040: 3473: 1532:
The antiarrhythmic effects of beta blockers arise from sympathetic nervous system blockade—resulting in depression of
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are located mainly in the lungs, gastrointestinal tract, liver, uterus, vascular smooth muscle, and skeletal muscle.
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Kim HY, Jung YJ, Lee SH, Jung HJ, Pak K (2017). "Is Beta-Blocker Use Beneficial in Breast Cancer? A Meta-Analysis".
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Safi S, Sethi NJ, Nielsen EE, Feinberg J, Jakobsen JC, Gluud C, et al. (Cochrane Heart Group) (December 2019).
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Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH, et al. (Cochrane Hypertension Group) (January 2017).
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A 2007 study revealed diuretics and beta blockers used for hypertension increase a patient's risk of developing
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Shek E, Bardhan S, Cheine MV, Ahonen J, Wahlbeck, et al. (Cochrane Schizophrenia Group) (September 1996).
5244:"Effects of Prolonged Use of β-Adrenoblockers on Melatonin Secretion, Sleep Quality, and Vascular Brain Damage" 2584:"Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology" 1913: 1691: 1674:. Conversely, central nervous system-related benefits of beta blockers may include prevention and treatment of 1316: 1031: 7822: 4344: 1060: 10139: 8257: 5291:"Treatment of a patient with a circadian sleep-wake disorder using a combination of melatonin and metoprolol" 5104: 4068: 2238: 17: 5940: 5187:
Stoschitzky, K.; Sakotnik, A.; Lercher, P.; Zweiker, R.; Maier, R.; Liebmann, P.; Lindner, W. (April 1999).
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blockers) can be prescribed at the least possible dose to those with mild to moderate respiratory symptoms.
11176: 11094: 8593: 7943: 7044: 6826: 6467:, August 20, 2008. (Discusses the use of propranolol by a North Korean pistol shooter in the 2008 Olympics) 3539:
Blessberger H, Lewis SR, Pritchard MW, Fawcett LJ, Domanovits H, Schlager O, et al. (September 2019).
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Blessberger H, Lewis SR, Pritchard MW, Fawcett LJ, Domanovits H, Schlager O, et al. (September 2019).
1563: 1324: 1315:, used in the treatment of overdose, increases the strength of heart contractions, increases intracellular 1275:
Beta blockers' inhibition on epinephrine's effect can somewhat exacerbate hypoglycemia by interfering with
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A 2014 Cochrane review investigated the use of beta blockers in the maintenance of chronic type B thoracic
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Therapeutic administration of beta blockers for congestive heart failure ought to begin at very low doses (
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James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. (February 2014).
11181: 9973: 9523: 9263: 8851: 8563: 8393: 8085: 7655: 6716: 6495: 6434: 3593:"First-line beta-blockers versus other antihypertensive medications for chronic type B aortic dissection" 2218:
Beta blockers, due to their antagonism at beta-1 adrenergic receptors, inhibit both the synthesis of new
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may be useful for treating CNS and cardiovascular toxicity from a methamphetamine overdose. The mixed
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Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J, et al. (March 2000).
9446: 8621: 8485: 8475: 6524: 6474: 4112: 3943: 1403:) exhibit intrinsic sympathomimetic activity (ISA). These agents are capable of exerting low-level 410: 389: 260: 180: 10094: 264: 8364: 7360: 7038: 6889: 6757: 1611: 1562:
Blockade of the sympathetic nervous system on renin release leads to reduced aldosterone via the
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and is considered by many to be one of the most important contributions to clinical medicine and
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Tyrer P (January 1992). "Anxiolytics not acting at the benzodiazepine receptor: beta blockers".
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effect on the heart and increases cardiac conduction velocity and automaticity. Stimulation of β
11171: 9859: 9551: 9541: 9112: 8869: 8787: 8727: 8700: 8599: 8284: 7397: 7152: 6488: 5078: 1917: 1916:. The function of cAMP as a second messenger in the cardiac cell is that it phosphorylates the 1667: 1615: 1515: 1351: 607: 535:. However, many controlled trials in the past 25 years indicate beta blockers are effective in 234: 5136:
Cojocariu SA, Maștaleru A, Sascău RA, Stătescu C, Mitu F, Leon-Constantin MM (February 2021).
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Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, et al. (August 1995).
2432: 10058: 9834: 9477: 8057: 7082: 7018: 6863: 5915:"DailyMed - BETAPACE- sotalol hydrochloride tablet BETAPACE AF- sotalol hydrochloride tablet" 3728:
Hollingsworth JM, Canales BK, Rogers MA, Sukumar S, Yan P, Kuntz GM, Dahm P (December 2016).
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Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y, et al. (Cochrane Heart Group) (July 2020).
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Intermediate lipophilicity: metoprolol, bisoprolol, carvedilol, acebutolol, timolol, pindolol
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effects. Central nervous system-related side effects and risks of beta blockers may include
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Low lipophilicity (also known as hydrophilic beta blockers): atenolol, nadolol, and sotalol
1796: 1655: 1566:, with a resultant decrease in blood pressure due to decreased sodium and water retention. 973: 944: 818: 713: 311: 223: 214:, are a class of medications that are predominantly used to manage abnormal heart rhythms ( 1067: 8: 10396: 10262: 9738: 9644: 9041: 8947: 8840: 8731: 8717: 8636: 8459: 8248: 7766: 7502: 7288: 7067: 6894: 4574: 4459:"Cardioselective beta-blockers in patients with reactive airway disease: a meta-analysis" 3281:"Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension" 2929:
Packer M, Fowler MB, Roecker EB, Coats AJ, Katus HA, Krum H, et al. (October 2002).
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and others are selective for one of the three known types of beta receptors, designated β
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Effects of β-Blockers With and Without Vasodilating Properties on Central Blood Pressure
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Reinhart, Marcia; Puil, Lorri; Salzwedel, Douglas M.; Wright, James M. (July 13, 2023).
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Chan KK, Lai P, Wright JM, et al. (Cochrane Hypertension Group) (February 2014).
2674:"First-line diuretics versus other classes of antihypertensive drugs for hypertension" 2600: 2583: 1924:
to increase intracellular calcium levels and cause contraction. Beta-blockade of the β
1027: 10827: 10802: 10722: 9600: 9350: 9215: 7806: 7761: 7544: 7534: 7437: 7267: 7223: 7207: 7011: 7001: 6944: 6934: 6449:, October 17, 2004. (Discusses the use of beta blockers among professional musicians) 6414: 6340: 6332: 6295: 6264: 6229: 6193: 6174: 6157: 6108: 6059: 5870: 5804: 5767: 5744: 5620: 5563: 5432: 5428: 5328: 5310: 5275: 5263: 5216: 5208: 5169: 5051: 5017: 4978: 4938: 4902: 4864: 4828: 4794: 4769: 4725: 4689: 4655: 4556: 4521: 4480: 4439: 4285: 4281: 4216: 4159: 4093: 4022: 3881: 3846: 3842: 3808: 3759: 3708: 3671: 3622: 3570: 3518: 3433: 3429: 3398: 3362: 3310: 3251: 3217: 3187: 3127: 3105: 3056: 3004:"Use of beta-blockers and ivabradine in heart failure with reduced ejection fraction" 2952: 2911: 2875: 2832: 2809: 2760: 2711: 2693: 2654: 2605: 2556: 2490: 2440: 2399: 2367: 2326: 2321: 2296: 2207: 1639: 1635: 1556: 1407:
activity at the β-adrenergic receptor while simultaneously acting as a receptor site
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drugs to administer during hypertensive crisis resulting from stimulant overdose are
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Koo HK, Lawrence KA, Musini VM, et al. (Cochrane Heart Group) (November 2017).
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Relative contraindications, or contraindications specific to certain beta-blockers:
484:. During a myocardial infarction, systemic stress causes an increase in circulating 10797: 10361: 10204: 10003: 9581: 9343: 9333: 8894: 7879: 7857: 7771: 7594: 7519: 7507: 7432: 7298: 7177: 6966: 6406: 6383: 6371: 6324: 6276: 6256: 6221: 6185: 6147: 6139: 6098: 6090: 6049: 6039: 5860: 5852: 5796: 5734: 5610: 5602: 5555: 5424: 5318: 5302: 5255: 5200: 5159: 5149: 4761: 4575:"Toxicity, Beta-blocker: Treatment & Medication – eMedicine Emergency Medicine" 4548: 4511: 4470: 4431: 4416: 4414: 4386: 4277: 4206: 4198: 4151: 4012: 3873: 3838: 3798: 3790: 3749: 3741: 3661: 3657: 3653: 3612: 3608: 3604: 3560: 3552: 3508: 3500: 3425: 3390: 3352: 3348: 3344: 3300: 3296: 3292: 3177: 3173: 3169: 3095: 3091: 3087: 3046: 2983: 2942: 2903: 2865: 2799: 2795: 2791: 2750: 2746: 2742: 2701: 2689: 2685: 2644: 2640: 2636: 2595: 2548: 2480: 2357: 2316: 2308: 1679: 1623: 1552: 1541: 1404: 1198: 1108: 965: 826: 141: 90: 55: 7238: 6143: 5638: 4752:
Ahrens RC (1990). "Skeletal muscle tremor and the influence of adrenergic drugs".
2226:. The neuropsychiatric side effects of some beta blockers (e.g. sleep disruption, 9595: 8903: 8809: 8170: 7811: 7756: 7625: 7620: 7459: 7392: 7387: 7273: 7219: 7060: 6951: 6904: 6126:
Kokolus KM, Zhang Y, Sivik JM, Schmeck C, Zhu J, Repasky EA, et al. (2018).
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Elman MJ, Sugar J, Fiscella R, Deutsch TA, Noth J, Nyberg M, et al. (1998).
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receptors in the heart only, but still have instrinsic sympathomimetic activity.
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effect to reduce sympathetic activity (for those beta blockers that do cross the
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and public performances. The application to stage fright was first recognized in
540: 539:, though the mechanism of action is not known. The physiological symptoms of the 350: 186: 8433: 6225: 5606: 4411: 2485: 2468: 10707: 10376: 10341: 10062: 9818: 9728: 9481: 9346: 9066: 9021: 8370: 8121: 8103: 7852: 7790: 7690: 7685: 7539: 7529: 7479: 7464: 7454: 7355: 7350: 7340: 7278: 7250: 7202: 7197: 6929: 6884: 6880: 6763: 6410: 6189: 6077:
Choy C, Raytis JL, Smith DD, Duenas M, Neman J, Jandial R, Lew MW (June 2016).
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Wong GW, Wright JM, et al. (Cochrane Hypertension Group) (February 2014).
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Acebutolol, pindolol, labetalol, mepindolol, oxprenolol, celiprolol, penbutolol
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Classical musicians have commonly used beta blockers since the 1970s to reduce
693: 630: 248: 6375: 6328: 4765: 3794: 3556: 3504: 2312: 11165: 10857: 10697: 10381: 10325: 10282: 9943: 9867: 9733: 9672: 9561: 9450: 9362: 9116: 9036: 9031: 8975: 8962: 8642: 8627: 8608: 8573: 8554: 8526: 8450: 8217: 8131: 8042: 7870: 7853: 7722: 7695: 7554: 7372: 7283: 7263: 7259: 7122: 7050: 6939: 6854: 6336: 5314: 5267: 5243: 5212: 5154: 4304: 4202: 3937:"The World Anti-Doping Code: The 2006 Prohibited List International Standard" 3877: 2870: 2853: 2697: 2362: 2345: 1607: 1460: 1411:. These agents, therefore, may be useful in individuals exhibiting excessive 1292: 1188: 1152: 960: 782: 626: 485: 451: 426: 385: 361: 241: 6044: 5415:
Rosendorff C (June 1993). "Beta-blocking agents with vasodilator activity".
5188: 3974:"Olympics: North Korea's Kim Jong-su loses medals after positive drugs test" 3381:
Schneier FR (September 2006). "Clinical practice. Social anxiety disorder".
2907: 1490:
Beta blockers inhibit these normal epinephrine- and norepinephrine-mediated
1338:
receptor-blocking effects of nonselective beta blockers may be treated with
1245: 10882: 10867: 10812: 10307: 10129: 10074: 10066: 10038: 9998: 9917: 9883: 9698: 9493: 9485: 9466: 9454: 9338: 9207: 9183: 8778: 8680: 8613: 8302: 8225: 8111: 8047: 7981: 7961: 7861: 7680: 7599: 7335: 7293: 7127: 7117: 7028: 6582: 6515: 6463: 6418: 6360:"Beta-blocker supplementation of standard drug treatment for schizophrenia" 6344: 6317:"Beta-blocker supplementation of standard drug treatment for schizophrenia" 6316: 6268: 6233: 6197: 6161: 6112: 6063: 5874: 5808: 5748: 5624: 5332: 5220: 5173: 4525: 4484: 4443: 4289: 4220: 4163: 4097: 4026: 4001:"The effect of propranolol versus placebo on resident surgical performance" 3885: 3850: 3812: 3763: 3675: 3626: 3574: 3522: 3402: 3366: 3314: 3255: 3221: 3191: 3109: 3060: 2956: 2915: 2879: 2813: 2764: 2715: 2658: 2560: 2539:
blockers. The Netherlands Working Group on Cardiovascular Research (WCN)".
2371: 2330: 2223: 2150: 2082:
Carvedilol, propranolol > oxprenolol > labetalol, metoprolol, timolol
1526: 1440: 1359: 1269: 1249: 1146: 989: 969: 940: 887: 881: 877: 869: 762: 739: 611: 555: 354: 219: 103: 86: 8423: 5856: 5567: 5436: 5204: 4773: 4560: 4435: 3437: 2609: 2494: 11007: 10982: 10977: 10972: 10862: 10837: 10822: 10807: 10772: 10757: 10737: 10732: 10702: 10682: 10657: 10642: 10587: 10532: 10461: 10456: 10451: 10411: 10406: 10312: 10297: 10267: 10257: 10242: 10213: 10184: 10028: 10018: 9993: 9983: 9948: 9891: 9854: 9783: 9778: 9758: 9723: 9659: 9634: 9624: 9605: 9566: 9436: 9313: 9308: 9268: 9243: 9233: 9223: 9193: 9188: 9163: 9138: 9132: 9097: 9056: 9051: 9016: 9001: 8996: 8942: 8932: 8913: 8874: 8773: 8757: 8723: 8713: 8675: 8632: 8568: 8507: 8470: 8455: 8340: 8328: 8116: 8052: 8015: 7971: 7951: 7933: 7923: 7564: 7474: 7214: 7167: 7112: 6995: 6961: 6587: 6094: 4367: 3904:"Golf: O'Grady says players use beta-blockers: Drugs 'helped win majors'" 3394: 2731:"Calcium channel blockers versus other classes of drugs for hypertension" 2729:
Zhu J, Chen N, Zhou M, Guo J, Zhu C, Zhou J, et al. (January 2022).
2203: 2195: 2168: 2142: 2001: 1820: 1714: 1627: 1412: 1343: 1323:. It is, therefore, useful in patients with beta blocker cardiotoxicity. 1280: 1103: 1098: 873: 850: 786: 778: 774: 729: 725: 657: 450:
secretion, which in turn reduces the heart oxygen demand by lowering the
346: 342: 331: 244: 59: 11072: 11062: 11052: 11037: 11032: 11017: 10997: 10992: 10967: 10962: 10947: 10927: 10922: 10917: 10887: 10877: 10872: 10842: 10832: 10792: 10782: 10762: 10712: 10692: 10672: 10667: 10647: 10632: 10627: 10617: 10597: 10592: 10582: 10577: 10572: 10552: 10537: 10527: 10507: 10486: 10471: 10446: 10441: 10436: 10421: 10416: 10401: 10386: 10371: 10366: 10356: 10346: 10302: 10287: 10277: 10252: 10247: 10228: 10218: 10199: 10194: 10174: 10169: 10159: 10154: 10144: 10134: 10124: 10114: 10109: 10053: 10043: 10033: 10023: 9963: 9953: 9933: 9928: 9913: 9887: 9879: 9875: 9849: 9844: 9793: 9788: 9768: 9763: 9718: 9708: 9703: 9693: 9654: 9639: 9629: 9590: 9576: 9472: 9462: 9423: 9418: 9408: 9403: 9393: 9378: 9354: 9328: 9318: 9303: 9298: 9288: 9283: 9253: 9238: 9211: 9173: 9159: 9155: 9151: 9128: 9124: 9087: 9046: 9026: 9006: 8991: 8957: 8937: 8889: 8884: 8793: 8783: 8747: 8742: 8690: 8502: 8494: 8336: 8310: 8270: 8265: 8202: 8187: 8149: 8020: 8010: 7928: 7918: 7742: 7713: 7671: 7640: 7635: 7574: 7569: 7559: 7497: 7483: 7423: 7378: 7326: 7246: 7242: 7183: 7143: 7098: 7094: 6984: 6920: 6870: 6835: 6831: 6733: 6728: 6706: 6669: 6649: 6644: 6639: 6624: 6597: 6573: 6568: 6558: 6553: 6543: 6538: 6533: 6396: 5841:"Changing beta-blockers in heart failure: when is a class not a class?" 5559: 2778:
Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH (January 2017).
2623:
Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH (January 2017).
2183:(preventive treatment before and primary treatment after heart attacks) 2180: 2176: 2164: 2124: 2120: 2116: 1996: 1963: 1957: 1952: 1936: 1871: 1865: 1840: 1825: 1792: 1738: 1734: 1730: 1722: 1706: 1695: 1583: 1551:, in particular, has additional antiarrhythmic properties and prolongs 1533: 1400: 1392: 1384: 1355: 1163: 981: 952: 905:, which work together to increase plasma glucose. Therefore, blocking β 854: 838: 681: 638: 564: 528: 422: 418: 414: 238: 215: 41: 6480: 6260: 5723:"β-Blockers in hypertension: studies and meta-analyses over the years" 5306: 5242:
Tikhomirova, O. V.; Zybina, N. N.; Kozhevnikova, V. V. (May 1, 2022).
5010:"Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment" 3745: 3158:"Beta-blockers for suspected or diagnosed acute myocardial infarction" 898:
breakdown (glycogenolysis) in the liver and pancreatic release of the
199: 11067: 11057: 11042: 11022: 11012: 10987: 10957: 10937: 10932: 10912: 10907: 10902: 10852: 10847: 10817: 10787: 10777: 10742: 10727: 10687: 10677: 10662: 10652: 10637: 10612: 10607: 10602: 10567: 10562: 10542: 10512: 10476: 10431: 10426: 10391: 10351: 10292: 10272: 10233: 10179: 10164: 10149: 10119: 10080: 10048: 10013: 10008: 9978: 9923: 9905: 9901: 9871: 9863: 9803: 9743: 9713: 9688: 9649: 9615: 9571: 9509: 9440: 9432: 9413: 9398: 9388: 9383: 9368: 9358: 9323: 9293: 9278: 9273: 9258: 9248: 9227: 9198: 9178: 9167: 9120: 9107: 9102: 9092: 9082: 9011: 8952: 8923: 8879: 8798: 8670: 8665: 8660: 8531: 8518: 8465: 8318: 8192: 8182: 8126: 8093: 7986: 7966: 7956: 7913: 7908: 7650: 7630: 7604: 7579: 7514: 7492: 7320: 7233: 7107: 6738: 6684: 6679: 6674: 6664: 6634: 6548: 4187:"NICE removes beta blockers as first line treatment for hypertension" 3051: 3034: 2219: 2138: 2134: 2105: 2037: 2017: 1968: 1947: 1850: 1835: 1758: 1750: 1742: 1726: 1683: 1663: 1651: 1631: 1595: 1579: 1484: 1444: 1396: 1203: 1178: 977: 956: 810: 794: 677: 669: 614:. These antagonists have a been proven to relieve the pain caused by 377: 330:
and lead to stress responses, especially when they are stimulated by
127: 4898:
Improving Oral Health for the Elderly: An Interdisciplinary Approach
2537: 1005: 735:
For similar reasons, beta blockers have also been used by surgeons.
515:
in heart rate, without a corresponding reduction in blood pressure.
10952: 10942: 10892: 10767: 10752: 10747: 10557: 10522: 10517: 10491: 10466: 10333: 10223: 10189: 10070: 9968: 9958: 9938: 9909: 9895: 9839: 9813: 9798: 9680: 9610: 9499: 9489: 9373: 9219: 9203: 9147: 8983: 8918: 8579: 8559: 8425: 8306: 8207: 8197: 7991: 7751: 7615: 7611: 7584: 7023: 6956: 6875: 6654: 6629: 6578: 6210: 3642:"Beta-blockers for preventing aortic dissection in Marfan syndrome" 2295:
Freemantle N, Cleland J, Young P, Mason J, Harrison J (June 1999).
2227: 2160: 1942: 1877: 1746: 1710: 1675: 1659: 1647: 1388: 1312: 1193: 921:. Therefore, beta blockers are to be used cautiously in diabetics. 902: 895: 806: 798: 758: 649: 645: 430: 365: 1279:
and mask signs of hypoglycemia such as tachycardia, palpitations,
1023: 618:, and also the infarction size, which correlates with heart rate. 11047: 11027: 11002: 10897: 10622: 10547: 9988: 9556: 9504: 9458: 8685: 7727: 7645: 7310: 7077: 6899: 6849: 6659: 6602: 6592: 6563: 5545: 5186: 4491: 3727: 3124:
Goodman & Gilman's: The Pharmacological Basic of Therapeutics
2851: 2191: 2172: 2146: 2101: 2097: 1973: 1889: 1883: 1860: 1766: 1762: 1754: 1718: 1687: 1548: 1506:
receptors is overshadowed by the more dominant vasoconstricting α
899: 822: 766: 705: 665: 547: 511:
Beta blockers are widely used for the treatment of hypertension.
496: 369: 73: 5135: 4450: 3538: 3486: 3418:
Progress in Neuro-Psychopharmacology & Biological Psychiatry
2892: 2437:
Pharmacotherapeutics for advanced practice: a practical approach
2023: 434:
in ejection fraction, worsening the patient's current symptoms.
10317: 9664: 9546: 8967: 8429: 7409: 7072: 5766:. Berlin, Heidelberg: Springer Berlin Heidelberg. p. 523. 4296: 1439:
receptors by epinephrine and norepinephrine induces a positive
1211: 1157: 754: 373: 368:
have shown that although beta blockers are more effective than
323: 319: 315: 6290:
Joseph S (1997). "Chapter 3, Schizoid Personality Disorder.".
3863: 3824: 3822: 376:
and total cardiovascular events, they are not as effective as
50: 7709: 7419: 6914: 5241: 3073: 2466: 1745:, and low lipophilicity or hydrophilic beta blockers include 1472: 1452: 1234: 842: 447: 307: 155: 4538: 4420: 4267: 3857: 3828: 3330: 2777: 2622: 9748: 7413: 6455:
by Blair Tindall. A condensed version of the above article.
5138:"Neuropsychiatric Consequences of Lipophilic Beta-Blockers" 4041:"Musicians Use Beta Blockers as Performance-Enabling Drugs" 3819: 3704:
The Modern Role of Beta-Blockers in Cardiovascular Medicine
2671: 2294: 1610:(fat solubility) and in turn in their ability to cross the 701: 341:
synthesized the first clinically significant beta blockers—
5716: 5714: 5712: 4084:
Cruickshank JM (2010). "Beta-blockers and heart failure".
2389: 2247:
are not contraindicated in those receiving beta blockers.
5786: 5720: 3998: 2113:
Agents specifically labeled for congestive heart failure
872:, inhibits renin release, thus decreasing the release of 6125: 5380: 5378: 5376: 5374: 5372: 5370: 5368: 5366: 5364: 5362: 4456: 3934: 3776: 3700: 3155: 3076:"Beta-blockers for congestive heart failure in children" 2928: 2343: 1853:(has intrinsic sympathomimetic activity and additional α 570:
International Conference of Symphony Orchestra Musicians
6357: 6292:
Personality Disorders: New Symptom-Focused Drug Therapy
5889:"DailyMed - BREVIBLOC- esmolol hydrochloride injection" 5709: 5360: 5358: 5356: 5354: 5352: 5350: 5348: 5346: 5344: 5342: 4457:
Salpeter SR, Ormiston TM, Salpeter EE (November 2002).
4263: 4261: 3035:"Beta-blockers: new standard therapy for heart failure" 2430: 2237:
Beta blockers have also been used for the treatment of
833:/β-antagonist therapy is also commonly associated with 480:
Beta blockers are indicated for the treatment of acute
6019: 5881: 4236:"Methamphetamine Toxicity: Treatment & Management" 4227: 2157:
Agents specifically labeled for myocardial infarction
6819:
Anatomical Therapeutic Chemical Classification System
6076: 5079:"Labetalol Hydrochloride Monograph for Professionals" 4500:"Glucose counterregulatory responses to hypoglycemia" 4005:
Transactions of the American Ophthalmological Society
2188:
Agents specifically labeled for migraine prophylaxis
2062:
Agents organized by lipid solubility (lipophilicity)
1370: 644:
Beta blockers are used to treat acute cardiovascular
546:
Musicians, public speakers, actors, and professional
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Frishman WH, Cheng-Lai A, Nawarskas J, eds. (2005).
1569: 1233:
The 2007 National Heart, Lung, and Blood Institute (
409:
Although beta blockers were once contraindicated in
287:
are located mainly in the heart and in the kidneys.
4233: 3534: 3532: 2094:Agents specifically labeled for cardiac arrhythmia 2054:Agents with intrinsic sympathomimetic action (ISA) 1601: 1430: 495:A 2019 Cochrane review compared beta blockers with 425:are specifically indicated as adjuncts to standard 8839: 5289:Gehrman, Philip R.; Anafi, Ron C. (October 2021). 4966: 3965: 2439:. Lippincott Williams & Wilkins. p. 205. 1268:Epinephrine signals early warning of the upcoming 753:associated with the use of beta blockers include: 446:at the kidneys. Beta blockers cause a decrease in 5989: 5721:Larochelle P, Tobe SW, Lacourcière Y (May 2014). 5189:"Influence of beta-blockers on melatonin release" 4890: 4319: 3639: 3032: 1618:. Beta blockers with greater blood–brain barrier 1354:. Other antidotes for beta blocker poisoning are 1327:is usually reserved for patients unresponsive to 995: 708:. Beta blockers are banned in some sports by the 11163: 5016:. Vol. 2. Blackwell Science. p. 1564. 3529: 3326: 3324: 2426: 2424: 2422: 1260:β-blocker-induced worsening asthma and/or COPD. 568:in 1976, and by 1987, a survey conducted by the 5131: 5129: 5127: 5125: 5123: 5121: 5119: 5117: 5085:. American Society of Health-System Pharmacists 4928: 4681: 4497: 4361: 4113:"Beta-Adrenoceptor Antagonists (Beta-Blockers)" 4110:Beta-Adrenoceptor Antagonists (Beta-Blockers); 3935:World Anti-Doping Agency (September 19, 2005). 3250:. Treasure Island (FL): StatPearls Publishing. 3216:. Treasure Island (FL): StatPearls Publishing. 2385: 2383: 2381: 527:Officially, beta blockers are not approved for 62:, the first clinically successful beta blocker. 8285: 6246: 5050:. Vol. 6. Blackwell Science. p. 76. 4469:(9). American College of Physicians: 715–725. 4378:The Journal of Allergy and Clinical Immunology 3777:Giovannitti JA, Thoms SM, Crawford JJ (2015). 3203: 3201: 2728: 2048: 1721:, moderately lipophilic beta blockers include 1252:where it exerts greater efficacy on reversing 550:have been known to use beta blockers to avoid 475: 349:; it revolutionized the medical management of 8825: 8409: 7838: 6802: 6496: 6315:Cheine, M.; Ahonen, J.; Wahlbeck, K. (2001). 5967:"Metiprapanol – metipranolol solution/ drops" 5764:Pharmacology of Antihypertensive Therapeutics 5511: 5509: 5478: 5476: 4964: 4685:Harrison's Nephrology and Acid-Base Disorders 3590: 3321: 2419: 1939:(has intrinsic sympathomimetic activity, ISA) 1334:People experiencing bronchospasm due to the β 919:beta blocker-induced hypoglycemia unawareness 8218:Non-selective α-adrenergic receptor blockers 6817:Major chemical drug groups – based upon the 5761: 5288: 5114: 4969:100 Questions and Answers about Hypertension 4652:The Adrenergic Receptors in the 21st Century 4178: 4141: 4135: 4077: 3770: 3721: 3586: 3584: 3374: 3274: 3272: 3151: 3149: 3147: 3145: 3143: 3026: 2922: 2886: 2845: 2820: 2378: 1174:Chronic obstructive pulmonary disease (COPD) 1127:Long QT syndrome: sotalol is contraindicated 1032:introducing citations to additional sources 687: 6321:The Cochrane Database of Systematic Reviews 5973:. U.S. National Library of Medicine – NIH. 4745: 4648:"Adrenergic Receptors in Clinical Medicine" 4645: 4532: 4083: 3646:The Cochrane Database of Systematic Reviews 3597:The Cochrane Database of Systematic Reviews 3545:The Cochrane Database of Systematic Reviews 3493:The Cochrane Database of Systematic Reviews 3337:The Cochrane Database of Systematic Reviews 3285:The Cochrane Database of Systematic Reviews 3198: 3162:The Cochrane Database of Systematic Reviews 3080:The Cochrane Database of Systematic Reviews 2784:The Cochrane Database of Systematic Reviews 2735:The Cochrane Database of Systematic Reviews 2678:The Cochrane Database of Systematic Reviews 2629:The Cochrane Database of Systematic Reviews 2531: 2431:Barranger K, Vivian E, Peterson AM (2006). 2337: 2288: 1586:) exhibit mixed antagonism of both β- and α 606:Adrenergic antagonists are mostly used for 404: 360:For the treatment of primary hypertension, 8832: 8818: 8416: 8402: 7845: 7831: 6809: 6795: 6503: 6489: 6032:Journal of Cardiovascular Disease Research 5834: 5832: 5830: 5828: 5826: 5506: 5473: 5414: 4498:Sprague JE, Arbeláez AM (September 2011). 4073:. Adelaide: Australian Medicines Handbook. 3457: 3455: 3278: 3241: 2575: 2460: 2277:Discovery and development of beta-blockers 2065:High lipophilicity: propranolol, labetalol 2043: 1298: 845:. Due to the high penetration across the 218:), and to protect the heart from a second 49: 6473:at the U.S. National Library of Medicine 6151: 6102: 6053: 6043: 5864: 5738: 5614: 5588: 5548:European Journal of Clinical Pharmacology 5322: 5193:European Journal of Clinical Pharmacology 5163: 5153: 4716:Lewis KP, Gonzalez RM, Balonov K (2009). 4636:USMLE WORLD 2009 Step1, Pharmacology, Q85 4599: 4515: 4474: 4390: 4369:National Heart, Lung, and Blood Institute 4210: 4016: 3897: 3895: 3802: 3753: 3665: 3616: 3581: 3564: 3512: 3356: 3304: 3269: 3207: 3181: 3140: 3099: 3050: 3033:Pritchett AM, Redfield MM (August 2002). 2987: 2946: 2869: 2831:. Philadelphia: Saunders. pp. 6–18. 2803: 2754: 2705: 2648: 2599: 2581: 2484: 2361: 2320: 2131:Agents specifically labeled for glaucoma 2088: 1886:(not considered a "typical beta blocker") 1808:Nonselective beta blockers display both β 326:, and other tissues that are part of the 306:Beta receptors are found on cells of the 5539: 4996:beta blockers dilation of blood vessels. 4718:"Vasoactive Amines and Inotropic Agents" 4062: 4060: 4058: 3380: 2969: 2501: 1960:(has intrinsic sympathomimetic activity) 1880:(has intrinsic sympathomimetic activity) 1874:(has intrinsic sympathomimetic activity) 1868:(has intrinsic sympathomimetic activity) 1791: 1256:β-blocker-induced bronchospasm than the 1248:can somewhat mitigate β-blocker-induced 1022:Relevant discussion may be found on the 263:. Some block activation of all types of 6510: 6364:Cochrane Database of Systematic Reviews 5845:The British Journal of General Practice 5838: 5823: 4931:"Beta Antagonist (Blocker) Medications" 4820: 4476:10.7326/0003-4819-137-9-200211050-00035 4066: 3916:from the original on September 25, 2015 3461: 3452: 2435:. In Arcangelo VP, Peterson AM (eds.). 1979:Nebivolol and bisoprolol are the most β 1376:compound, such as norepinephrine). See 909:-adrenoceptors lowers plasma glucose. β 14: 11164: 7796:Pharmacological classification systems 7163:Selective estrogen receptor modulators 6289: 5789:Journal of Clinical Psychopharmacology 5248:Neuroscience and Behavioral Physiology 5105:"Coreg - Food and Drug Administration" 5047:Lecture notes on clinical pharmacology 4786: 4751: 4688:. McGraw-Hill Companies. p. 215. 4315:from the original on October 13, 2007. 4302: 4234:Richards JR, Derlet RW, Albertson TE. 3953:from the original on February 11, 2017 3901: 3892: 3014:from the original on December 22, 2015 2179:(after left ventricular dysfunction), 2007: 1986: 1895: 1803: 890:can occur with beta blockade because β 237:that block the receptor sites for the 226:). They are also widely used to treat 27:Medications for abnormal heart rhythms 8813: 8397: 7826: 7443:Non-steroidal anti-inflammatory drugs 6790: 6484: 6399:European Journal of Internal Medicine 6025: 6007:from the original on October 18, 2017 5997:"Drugs to Prevent Migraine in Adults" 5977:from the original on October 18, 2017 5697:from the original on October 18, 2017 5693:. U.S. National Library of Medicine. 5649:from the original on October 18, 2017 5645:. U.S. National Library of Medicine. 5527:from the original on October 18, 2017 5523:. U.S. National Library of Medicine. 5494:from the original on October 18, 2017 5490:. U.S. National Library of Medicine. 5461:from the original on October 18, 2017 5457:. U.S. National Library of Medicine. 5396:from the original on October 18, 2017 5007: 4184: 4055: 3971: 3415: 1415:with sustained beta blocker therapy. 442:activity in the heart, influence the 132: 6294:. Psychology Press. pp. 45–56. 5043: 4854: 4720:. In O'Donnell JM, Nácul FE (eds.). 3928: 2826: 1564:renin–angiotensin–aldosterone system 1263: 999: 943:, reduces coronary blood flow, left 849:, lipophilic beta blockers, such as 841:therapy is commonly associated with 769:, cold extremities, exacerbation of 7056:Angiotensin II receptor antagonists 5921:. U.S. National Library of Medicine 5895:. U.S. National Library of Medicine 5589:Sinha SS, Gurm HS (February 2014). 4602:"Beta-Adrenergic Blocker Poisoning" 4581:from the original on March 17, 2009 4123:from the original on August 8, 2011 3383:The New England Journal of Medicine 2519:from the original on March 27, 2010 2473:The New England Journal of Medicine 1912:receptors in the heart will act on 934:angiotensin II receptor antagonists 24: 6001:pharmacist.therapeuticresearch.com 5762:Ganten D, Mulrow PJ, eds. (1990). 5727:The Canadian Journal of Cardiology 5417:Journal of Hypertension Supplement 5390:pharmacist.therapeuticresearch.com 5386:"Comparison of Oral Beta-Blockers" 5295:Journal of Clinical Sleep Medicine 4901:. New York: Springer. p. 87. 4827:. Pearson Education. p. 394. 4246:from the original on April 9, 2016 3464:"Better Playing Through Chemistry" 2948:10.1161/01.CIR.0000035653.72855.BF 1771:intrinsic sympathomimetic activity 1371:Intrinsic sympathomimetic activity 1291:Abrupt withdrawal can result in a 1286: 894:-adrenoceptors normally stimulate 745: 25: 11193: 6428: 4342: 3980:. Guardian News and Media Limited 3701:John Malcolm Cruickshank (2010). 860:Adverse effects associated with β 7805: 7785: 7784: 6441:Better Playing Through Chemistry 6390: 6351: 6308: 6283: 6240: 6204: 6168: 6119: 6070: 5429:10.1097/00004872-199306003-00009 4935:The Encyclopedia of Men's Health 4929:Rothfeld GS, Romaine DS (2005). 4722:Surgical Intensive Care Medicine 4282:10.1016/j.drugalcdep.2015.01.040 3843:10.1016/j.drugalcdep.2015.01.040 3333:"Beta-blockers for hypertension" 2972:"Beta blockers in heart failure" 2780:"Beta-blockers for hypertension" 2625:"Beta-blockers for hypertension" 2213: 1602:Blood–brain barrier permeability 1431:β-Adrenergic receptor antagonism 1380:for a more general description. 1240:Cardio selective beta blocker (β 1015:relies largely or entirely on a 1004: 732:and was stripped of his medals. 11140:Monoamine metabolism modulators 8542:acetylcholinesterase inhibitors 8281:Endothelin receptor antagonists 8142:Tyrosine hydroxylase inhibitors 7193:Hypothalamic–pituitary hormones 6003:. Therapeutic Research Center. 5959: 5933: 5907: 5780: 5755: 5679: 5661: 5631: 5582: 5443: 5408: 5392:. Therapeutic Research Center. 5282: 5235: 5180: 5097: 5071: 5037: 5001: 4958: 4922: 4884: 4848: 4814: 4790:Sport and exercise pharmacology 4780: 4709: 4682:Jameson JL, Loscalzo J (2010). 4675: 4639: 4630: 4593: 4504:Pediatric Endocrinology Reviews 4104: 4033: 3992: 3694: 3682: 3633: 3480: 3409: 3235: 3116: 3067: 2996: 2963: 2771: 2722: 2665: 1983:cardioselective beta blockers. 1574:-Adrenergic receptor antagonism 1451:receptors on the kidney causes 1365: 1119:Second or third degree AV block 710:International Olympic Committee 506: 395: 8290:Tooltip Pulmonary hypertension 8258:Serotonin receptor antagonists 6459:In Defense of the Beta Blocker 4965:Manger WM, Gifford RW (2001). 4861:Encyclopedia of Heart Diseases 4793:. Human Kinetics. p. 19. 4303:Handly M (December 16, 2016). 3658:10.1002/14651858.CD011103.pub2 3609:10.1002/14651858.CD010426.pub2 3462:Tindall B (October 17, 2004). 3349:10.1002/14651858.CD002003.pub5 3297:10.1002/14651858.CD007452.pub2 3174:10.1002/14651858.CD012484.pub2 3092:10.1002/14651858.CD007037.pub4 2796:10.1002/14651858.cd002003.pub5 2747:10.1002/14651858.CD003654.pub6 2690:10.1002/14651858.CD008161.pub3 2641:10.1002/14651858.CD002003.pub5 2616: 1692:post-traumatic stress disorder 1463:relaxation, induces tremor in 1222:Wolff–Parkinson–White syndrome 996:Contraindications and cautions 801:(hair loss), abnormal vision, 13: 1: 11122:Monoamine reuptake inhibitors 11095:Receptor/signaling modulators 8594:Carbonic anhydrase inhibitors 8175:-Adrenergic receptor blockers 7944:Adrenergic release inhibitors 7901:-Adrenergic receptor agonists 6945:Thrombolytics / fibrinolytics 6453:Musicians using beta blockers 6144:10.1080/2162402X.2017.1405205 4973:. Blackwell Science. p.  4654:. Humana Press. p. 135. 4553:10.1016/S0196-0644(85)81081-7 4156:10.1016/S0140-6736(07)60108-1 4070:Australian Medicines Handbook 2588:Texas Heart Institute Journal 2282: 2239:schizoid personality disorder 2230:) may be due to this effect. 1700:obsessive–compulsive disorder 672:, and other drugs. Combined α 380:, medications inhibiting the 364:of studies which mostly used 8086:Monoamine oxidase inhibitors 7656:Wakefulness-promoting agents 5801:10.1097/JCP.0000000000000695 4646:Michel MC, Insel PA (2006). 4541:Annals of Emergency Medicine 4011:: 283–91, discussion 291–4. 3430:10.1016/0278-5846(92)90004-X 2989:10.18773/austprescr.2000.138 2396:Current Cardiovascular Drugs 2125:sustained-release metoprolol 1606:Beta blockers vary in their 1594:, which provides additional 1134:: sotalol is contraindicated 1095:Absolute contraindications: 533:Food and Drug Administration 222:after a first heart attack ( 7: 10205:Deoxyepinephrine (epinine, 9582:Deoxyepinephrine (epinine, 9429:Tetracyclic antidepressants 8895:Deoxyepinephrine (epinine, 6435:Musicians and beta-blockers 6226:10.1016/j.canep.2014.03.011 5607:10.1136/openhrt-2013-000010 4463:Annals of Internal Medicine 4430:(4). Elsevier BV: 779–786. 4345:"Propranolol hydrochloride" 4270:Drug and Alcohol Dependence 3972:Scott M (August 15, 2008). 3866:J Cardiovasc Pharmacol Ther 3707:. Shelton, Conn: PMPH-USA. 3242:Iqbal AH, Jamal SF (2023). 3045:(8): 839–845, quiz 845–46. 2486:10.1056/NEJM199508103330605 2250: 2078:membrane stabilizing effect 2049:Pharmacological differences 1307: 476:Acute myocardial infarction 10: 11198: 11131:Monoamine releasing agents 7306:Intravenous immunoglobulin 6411:10.1016/j.ejim.2016.08.003 6190:10.1016/j.ejca.2013.07.141 6178:European Journal of Cancer 5740:10.1016/j.cjca.2014.02.012 5260:10.1007/s11055-022-01270-y 4392:10.1016/j.jaci.2007.09.029 2553:10.1177/000331979905000602 2392:"Beta-Adrenergic Blockers" 2262:Sympathetic nervous system 2028:selective antagonist and β 1578:Some beta blockers (e.g., 1540:conduction, and prolonged 575: 522: 328:sympathetic nervous system 303:are located in fat cells. 257:sympathetic nervous system 11085: 10500: 10102: 10093: 9827: 9534: 9522: 9447:Tricyclic antidepressants 9075: 8862: 8850: 8766: 8699: 8651: 8592: 8540: 8516: 8493: 8484: 8441: 8354: 8279: 8256: 8246: 8216: 8169: 8162: 8140: 8102: 8084: 8077: 8070: 8029: 8000: 7942: 7895: 7888: 7869: 7780: 7736: 7708: 7664: 7473: 7408: 7371: 7319: 7232: 7176: 7136: 7093: 6977: 6913: 6825: 6747: 6715: 6693: 6611: 6523: 6376:10.1002/14651858.CD000234 6329:10.1002/14651858.CD000234 4863:. Elsevier. p. 160. 4766:10.3109/02770909009073289 3795:10.2344/0003-3006-62.1.31 3557:10.1002/14651858.CD013438 3505:10.1002/14651858.CD013435 2398:. Current Science Group. 2313:10.1136/bmj.318.7200.1730 2222:and its secretion by the 1787: 1626:therapeutic benefits and 1614:and exert effects in the 1495:causing asthma symptoms. 1455:release. Stimulation of β 1383:Some beta blockers (e.g. 1228: 688:Performance-enhancing use 656:, for instance caused by 558:, and tremor during both 253:adrenergic beta receptors 198: 193: 179: 174: 154: 140: 126: 121: 109: 97: 82: 72: 67: 48: 39: 34: 7361:Topoisomerase inhibitors 7045:renin–angiotensin system 7039:Calcium channel blockers 6475:Medical Subject Headings 6471:beta-Adrenergic+Blockers 5839:Aronson JK (June 2008). 5691:pubchem.ncbi.nlm.nih.gov 5643:pubchem.ncbi.nlm.nih.gov 5521:pubchem.ncbi.nlm.nih.gov 5488:pubchem.ncbi.nlm.nih.gov 5455:pubchem.ncbi.nlm.nih.gov 5155:10.3390/medicina57020155 4937:. Amaranth. p. 48. 4724:. Springer. p. 47. 4203:10.1136/bmj.333.7557.8-a 3944:World Anti-Doping Agency 3878:10.1177/1074248416681644 3244:"Essential Hypertension" 3208:Farzam K, Jan A (2023). 2871:10.1001/jama.283.10.1295 2363:10.1001/jama.2013.284427 1799:, the first beta blocker 1514:from the kidneys, and a 915:hypoglycemia unawareness 591: 444:renin–angiotensin system 421:, and sustained-release 411:congestive heart failure 405:Congestive heart failure 390:calcium channel blockers 382:renin–angiotensin system 261:fight-or-flight response 9860:Atypical antipsychotics 9113:Atypical antipsychotics 8701:Prostaglandin analogues 6045:10.4103/0975-3583.85261 5012:. In Schlant RC (ed.). 4305:"Toxicity, Amphetamine" 4043:. WQXR. August 16, 2013 3039:Mayo Clinic Proceedings 2908:10.1067/mhj.2002.120768 2044:Comparative information 1346:, which are safer than 1329:pharmacological therapy 1299:Bradycardia or AV block 1169:Cerebrovascular disease 1142:Abrupt discontinuations 835:orthostatic hypotension 676:and beta blockers like 235:competitive antagonists 10059:Typical antipsychotics 9542:(R)-3-Nitrobiphenyline 9478:Typical antipsychotics 7856:(and closely related) 7153:Hormonal contraception 7083:Bile acid sequestrants 6864:Proton-pump inhibitors 6827:gastrointestinal tract 4824:Anatomy and Physiology 2896:American Heart Journal 2089:Indication differences 1800: 1616:central nervous system 1516:central nervous system 1352:cardiovascular disease 1319:, and decreases renal 751:Adverse drug reactions 608:cardiovascular disease 482:myocardial infarctions 265:β-adrenergic receptors 11149:Monoamine neurotoxins 8035:nicotinic antagonists 6026:Fares A (July 2011). 5945:www.evaluategroup.com 5857:10.3399/bjgp08X299317 5205:10.1007/s002280050604 4754:The Journal of Asthma 4650:. In Perez DM (ed.). 4436:10.1378/chest.13-1235 4185:Mayor S (July 2006). 4067:Rossi S, ed. (2006). 3126:. McGraw-Hill. 2018. 2976:Australian Prescriber 2582:Stapleton MP (1997). 2509:"Sir James Black, OM" 2272:Adrenergic antagonist 2171:(immediate release), 2167:(immediate release), 1795: 1656:visual hallucinations 1630:, as well as adverse 1598:vasodilating action. 1538:atrioventricular node 1522:, e.g. propranolol). 616:myocardial infarction 357:of the 20th century. 301:-adrenergic receptors 293:-adrenergic receptors 285:-adrenergic receptors 259:, which mediates the 10718:Dichloroisoprenaline 8738:Latanoprostene bunod 8653:Beta blocking agents 8486:Parasympathomimetics 8002:Imidazoline receptor 7762:Radiopharmaceuticals 7550:Antiparkinson agents 6095:10.3892/or.2016.4710 5733:(5 Suppl): S16–S22. 4086:Indian Heart Journal 3395:10.1056/NEJMcp060145 1797:Dichloroisoprenaline 1779:-adrenergic receptor 1592:adrenergic receptors 1028:improve this article 945:ventricular function 819:erectile dysfunction 728:tested positive for 720:silver medalist and 714:2008 Summer Olympics 224:secondary prevention 11177:Scottish inventions 10397:Phenylpropanolamine 10263:Ethylnorepinephrine 9739:Phenylpropanolamine 9645:Ethylnorepinephrine 9042:Phenylpropanolamine 8948:Ethylnorepinephrine 8841:Adrenergic receptor 7545:Antimigraine agents 7535:Antidementia agents 7438:Anti-inflammatories 7128:Medicated dressings 7068:Antihyperlipidemics 6895:Diabetes medication 6214:Cancer Epidemiology 4821:Martini FH (2005). 4609:Courses.ahc.umn.edu 3831:Drug Alcohol Depend 3476:on August 26, 2015. 2970:Fletcher P (2000). 2829:Drugs for the Heart 2307:(7200): 1730–1737. 2267:Adrenergic receptor 1857:-blocking activity) 1847:-blocking activity) 1832:-blocking activity) 1804:Nonselective agents 1668:Parkinson's disease 1612:blood–brain barrier 1520:blood–brain barrier 1321:vascular resistance 1132:torsades de pointes 847:blood–brain barrier 722:10-metre air pistol 586:atrial fibrillation 552:performance anxiety 501:all-cause mortality 251:(noradrenaline) on 228:high blood pressure 11182:British inventions 8381:Never to phase III 7398:Immunosuppressants 7268:Antimycobacterials 7224:Antithyroid agents 7208:Mineralocorticoids 7012:Cardiac stimulants 7002:Cardiac glycosides 6994:cardiac therapy / 6890:Anti-obesity drugs 6774:Never to phase III 6446:The New York Times 6443:by Blair Tindall, 5560:10.1007/BF00191900 4399:on August 28, 2021 3469:The New York Times 2515:. March 23, 2010. 1922:ryanodine receptor 1801: 1545:refractory periods 1483:receptors induces 1479:. Stimulation of β 1459:receptors induces 1217:Vasospastic angina 1208:Reynaud phenomenon 815:sexual dysfunction 771:Raynaud's syndrome 582:heart dysrhythmias 233:Beta blockers are 11159: 11158: 11152: 11143: 11134: 11125: 11116: 11107: 11098: 11081: 11080: 10828:Iodocyanopindolol 10803:Hydroxytertatolol 10723:Dihydroalprenolol 10336: 10328: 10320: 10237: 10089: 10088: 9683: 9675: 9667: 9619: 9601:Dihydroergotamine 9518: 9517: 9351:hydroxynefazodone 9216:dihydroergotamine 8986: 8978: 8970: 8927: 8807: 8806: 8588: 8587: 8428:preparations and 8391: 8390: 8350: 8349: 8242: 8241: 8238: 8237: 8234: 8233: 8158: 8157: 8066: 8065: 8031:Ganglion-blocking 7858:antihypertensives 7820: 7819: 7723:Ophthalmologicals 7433:Anabolic steroids 7336:Anticancer agents 7299:Ectoparasiticides 7019:Antihypertensives 6967:Antifibrinolytics 6784: 6783: 6461:by Carl Elliott, 6261:10.1159/000455143 6184:(18): 3863–3871. 5307:10.5664/jcsm.9410 5301:(10): 2121–2124. 5057:978-0-632-05077-2 5023:978-0-07-912951-2 5014:Hurst's the Heart 4984:978-0-632-04481-8 4944:978-0-8160-5177-9 4908:978-0-387-74337-0 4870:978-0-12-406061-6 4834:978-0-8053-5947-3 4800:978-0-87322-937-1 4787:Reents S (2000). 4731:978-0-387-77892-1 4695:978-0-07-166339-7 4661:978-1-58829-423-4 4150:(9557): 201–207. 3746:10.1136/bmj.i6112 3714:978-1-60795-108-7 3389:(10): 1029–1036. 2941:(17): 2194–2199. 2864:(10): 1295–1302. 2838:978-1-4160-6158-8 2446:978-0-7817-5784-3 2405:978-1-57340-221-7 2208:phaeochromocytoma 2012:-selective agents 1991:-selective agents 1900:-selective agents 1843:(has additional α 1828:(has additional α 1557:potassium channel 1555:duration through 1350:in patients with 1264:Diabetes mellitus 1115:Cardiogenic shock 1093: 1092: 1078: 926:diabetes mellitus 917:. This is termed 537:anxiety disorders 247:(adrenaline) and 205: 204: 111:Biological target 68:Class identifiers 16:(Redirected from 11189: 11146: 11137: 11128: 11119: 11110: 11101: 11089: 10798:Hydroxycarteolol 10362:Methoxyphenamine 10334: 10326: 10321:-DOPA (levodopa) 10318: 10235: 10209:-methyldopamine) 10100: 10099: 10004:Phenoxybenzamine 9681: 9673: 9668:-DOPA (levodopa) 9665: 9617: 9586:-methyldopamine) 9532: 9531: 9344:Phenylpiperazine 9334:Phenoxybenzamine 8984: 8976: 8971:-DOPA (levodopa) 8968: 8925: 8909:Dexisometheptene 8899:-methyldopamine) 8860: 8859: 8834: 8827: 8820: 8811: 8810: 8491: 8490: 8443:Sympathomimetics 8418: 8411: 8404: 8395: 8394: 8291: 8287: 8254: 8253: 8167: 8166: 8082: 8081: 8075: 8074: 7893: 7892: 7886: 7885: 7880:vasoconstriction 7847: 7840: 7833: 7824: 7823: 7809: 7788: 7787: 7772:Senotherapeutics 7626:Neuroprotectives 7621:Mood stabilizers 7520:Anti-ADHD agents 7460:Muscle relaxants 7393:Immunostimulants 7388:Immunomodulators 7220:Thyroid hormones 7158:Fertility agents 7061:Renin inhibitors 6952:Antihemorrhagics 6919:forming organs ( 6905:Dietary minerals 6811: 6804: 6797: 6788: 6787: 6505: 6498: 6491: 6482: 6481: 6423: 6422: 6394: 6388: 6387: 6355: 6349: 6348: 6312: 6306: 6305: 6287: 6281: 6280: 6244: 6238: 6237: 6208: 6202: 6201: 6172: 6166: 6165: 6155: 6123: 6117: 6116: 6106: 6089:(6): 3135–3142. 6083:Oncology Reports 6074: 6068: 6067: 6057: 6047: 6023: 6017: 6016: 6014: 6012: 5993: 5987: 5986: 5984: 5982: 5963: 5957: 5956: 5954: 5952: 5937: 5931: 5930: 5928: 5926: 5911: 5905: 5904: 5902: 5900: 5885: 5879: 5878: 5868: 5851:(551): 387–389. 5836: 5821: 5820: 5784: 5778: 5777: 5759: 5753: 5752: 5742: 5718: 5707: 5706: 5704: 5702: 5683: 5677: 5676: 5665: 5659: 5658: 5656: 5654: 5635: 5629: 5628: 5618: 5586: 5580: 5579: 5543: 5537: 5536: 5534: 5532: 5513: 5504: 5503: 5501: 5499: 5480: 5471: 5470: 5468: 5466: 5447: 5441: 5440: 5412: 5406: 5405: 5403: 5401: 5382: 5337: 5336: 5326: 5286: 5280: 5279: 5239: 5233: 5232: 5184: 5178: 5177: 5167: 5157: 5133: 5112: 5111: 5109: 5101: 5095: 5094: 5092: 5090: 5075: 5069: 5068: 5066: 5064: 5044:Reid JL (2001). 5041: 5035: 5034: 5032: 5030: 5008:Hurst J (1997). 5005: 4999: 4998: 4993: 4991: 4972: 4962: 4956: 4955: 4953: 4951: 4926: 4920: 4919: 4917: 4915: 4888: 4882: 4881: 4879: 4877: 4855:Khan MI (2006). 4852: 4846: 4845: 4843: 4841: 4818: 4812: 4811: 4809: 4807: 4784: 4778: 4777: 4749: 4743: 4742: 4740: 4738: 4713: 4707: 4706: 4704: 4702: 4679: 4673: 4672: 4670: 4668: 4643: 4637: 4634: 4628: 4627: 4625: 4623: 4618:on March 3, 2016 4617: 4611:. Archived from 4606: 4597: 4591: 4590: 4588: 4586: 4571: 4565: 4564: 4536: 4530: 4529: 4519: 4495: 4489: 4488: 4478: 4454: 4448: 4447: 4418: 4409: 4408: 4406: 4404: 4395:. Archived from 4394: 4365: 4359: 4358: 4356: 4354: 4349: 4340: 4317: 4316: 4300: 4294: 4293: 4265: 4256: 4255: 4253: 4251: 4231: 4225: 4224: 4214: 4182: 4176: 4175: 4139: 4133: 4132: 4130: 4128: 4108: 4102: 4101: 4081: 4075: 4074: 4064: 4053: 4052: 4050: 4048: 4037: 4031: 4030: 4020: 3996: 3990: 3989: 3987: 3985: 3969: 3963: 3962: 3960: 3958: 3952: 3941: 3932: 3926: 3925: 3923: 3921: 3899: 3890: 3889: 3861: 3855: 3854: 3826: 3817: 3816: 3806: 3774: 3768: 3767: 3757: 3725: 3719: 3718: 3698: 3692: 3686: 3680: 3679: 3669: 3652:(11): CD011103. 3637: 3631: 3630: 3620: 3588: 3579: 3578: 3568: 3536: 3527: 3526: 3516: 3484: 3478: 3477: 3472:. Archived from 3459: 3450: 3449: 3413: 3407: 3406: 3378: 3372: 3370: 3360: 3328: 3319: 3318: 3308: 3276: 3267: 3266: 3264: 3262: 3239: 3233: 3232: 3230: 3228: 3205: 3196: 3195: 3185: 3168:(12): CD012484. 3153: 3138: 3137: 3120: 3114: 3113: 3103: 3071: 3065: 3064: 3054: 3052:10.4065/77.8.839 3030: 3024: 3023: 3021: 3019: 3008:www.uptodate.com 3000: 2994: 2993: 2991: 2967: 2961: 2960: 2950: 2926: 2920: 2919: 2890: 2884: 2883: 2873: 2849: 2843: 2842: 2827:Opie LH (2009). 2824: 2818: 2817: 2807: 2775: 2769: 2768: 2758: 2726: 2720: 2719: 2709: 2669: 2663: 2662: 2652: 2620: 2614: 2613: 2603: 2579: 2573: 2572: 2535: 2529: 2528: 2526: 2524: 2505: 2499: 2498: 2488: 2464: 2458: 2457: 2455: 2453: 2428: 2417: 2416: 2414: 2412: 2387: 2376: 2375: 2365: 2341: 2335: 2334: 2324: 2292: 1680:essential tremor 1624:neuropsychiatric 1553:action potential 1467:, and increases 1435:Stimulation of β 1199:Pheochromocytoma 1111:to beta blockers 1109:Hypersensitivity 1088: 1085: 1079: 1077: 1036: 1008: 1000: 966:antihypertensive 827:lipid metabolism 821:, alteration of 724:bronze medalist 654:sympathomimetics 531:use by the U.S. 471: 470: 466: 189: 170: 164: 150: 142:Consumer Reports 136: 56:Skeletal formula 53: 32: 31: 21: 11197: 11196: 11192: 11191: 11190: 11188: 11187: 11186: 11162: 11161: 11160: 11155: 11077: 10496: 10085: 9823: 9596:Dexmedetomidine 9527: 9514: 9347:antidepressants 9071: 8904:Desglymidodrine 8855: 8846: 8838: 8808: 8803: 8762: 8706: 8695: 8647: 8597: 8584: 8536: 8512: 8480: 8437: 8424:Drugs used for 8422: 8392: 8387: 8386: 8371:Clinical trials 8346: 8289: 8275: 8230: 8212: 8174: 8154: 8136: 8104:VMAT inhibitors 8098: 8062: 8025: 7996: 7938: 7900: 7878: 7873: 7865: 7851: 7821: 7816: 7812:Medicine portal 7776: 7732: 7704: 7699: 7691:Cough medicines 7686:Bronchodilators 7667: 7660: 7540:Antidepressants 7530:Anticonvulsants 7478: 7469: 7465:Bisphosphonates 7455:Corticosteroids 7417: 7404: 7376: 7367: 7351:Spindle poisons 7341:Antimetabolites 7324: 7315: 7237: 7228: 7203:Glucocorticoids 7198:Corticosteroids 7179: 7172: 7139: 7132: 7089: 7007:Antiarrhythmics 6980: 6973: 6930:Antithrombotics 6918: 6909: 6885:Antipropulsives 6881:Antidiarrhoeals 6858: 6829: 6821: 6815: 6785: 6780: 6779: 6764:Clinical trials 6743: 6722:- + β-selective 6720: 6711: 6698: 6689: 6616: 6607: 6527:, non-selective 6519: 6509: 6431: 6426: 6395: 6391: 6356: 6352: 6323:(3): CD000234. 6313: 6309: 6302: 6288: 6284: 6245: 6241: 6209: 6205: 6173: 6169: 6138:(3): e1405205. 6124: 6120: 6075: 6071: 6024: 6020: 6010: 6008: 5995: 5994: 5990: 5980: 5978: 5965: 5964: 5960: 5950: 5948: 5939: 5938: 5934: 5924: 5922: 5913: 5912: 5908: 5898: 5896: 5887: 5886: 5882: 5837: 5824: 5785: 5781: 5774: 5760: 5756: 5719: 5710: 5700: 5698: 5685: 5684: 5680: 5667: 5666: 5662: 5652: 5650: 5637: 5636: 5632: 5587: 5583: 5544: 5540: 5530: 5528: 5515: 5514: 5507: 5497: 5495: 5482: 5481: 5474: 5464: 5462: 5449: 5448: 5444: 5413: 5409: 5399: 5397: 5384: 5383: 5340: 5287: 5283: 5240: 5236: 5185: 5181: 5134: 5115: 5107: 5103: 5102: 5098: 5088: 5086: 5077: 5076: 5072: 5062: 5060: 5058: 5042: 5038: 5028: 5026: 5024: 5006: 5002: 4989: 4987: 4985: 4963: 4959: 4949: 4947: 4945: 4927: 4923: 4913: 4911: 4909: 4895:, eds. (2008). 4889: 4885: 4875: 4873: 4871: 4857:"Beta-Blockers" 4853: 4849: 4839: 4837: 4835: 4819: 4815: 4805: 4803: 4801: 4785: 4781: 4750: 4746: 4736: 4734: 4732: 4714: 4710: 4700: 4698: 4696: 4680: 4676: 4666: 4664: 4662: 4644: 4640: 4635: 4631: 4621: 4619: 4615: 4604: 4600:John Gualtier. 4598: 4594: 4584: 4582: 4573: 4572: 4568: 4537: 4533: 4496: 4492: 4455: 4451: 4419: 4412: 4402: 4400: 4385:(5): S94–S138. 4366: 4362: 4352: 4350: 4347: 4341: 4320: 4301: 4297: 4266: 4259: 4249: 4247: 4232: 4228: 4183: 4179: 4140: 4136: 4126: 4124: 4117:CV Pharmacology 4111: 4109: 4105: 4082: 4078: 4065: 4056: 4046: 4044: 4039: 4038: 4034: 3997: 3993: 3983: 3981: 3970: 3966: 3956: 3954: 3950: 3939: 3933: 3929: 3919: 3917: 3909:The Independent 3900: 3893: 3862: 3858: 3827: 3820: 3775: 3771: 3726: 3722: 3715: 3699: 3695: 3687: 3683: 3638: 3634: 3603:(2): CD010426. 3589: 3582: 3551:(9): CD013438. 3537: 3530: 3499:(9): CD013435. 3485: 3481: 3460: 3453: 3414: 3410: 3379: 3375: 3343:(1): CD002003. 3329: 3322: 3291:(2): CD007452. 3277: 3270: 3260: 3258: 3240: 3236: 3226: 3224: 3210:"Beta Blockers" 3206: 3199: 3154: 3141: 3134: 3122: 3121: 3117: 3086:(7): CD007037. 3072: 3068: 3031: 3027: 3017: 3015: 3002: 3001: 2997: 2968: 2964: 2927: 2923: 2891: 2887: 2850: 2846: 2839: 2825: 2821: 2790:(1): CD002003. 2776: 2772: 2741:(1): CD003654. 2727: 2723: 2684:(7): CD008161. 2670: 2666: 2635:(1): CD002003. 2621: 2617: 2580: 2576: 2536: 2532: 2522: 2520: 2507: 2506: 2502: 2465: 2461: 2451: 2449: 2447: 2429: 2420: 2410: 2408: 2406: 2388: 2379: 2342: 2338: 2293: 2289: 2285: 2253: 2245:Contrast agents 2234:breast cancer. 2216: 2091: 2051: 2046: 2034: 2031: 2027: 2014: 2011: 1993: 1990: 1982: 1931: 1927: 1911: 1907: 1902: 1899: 1856: 1846: 1831: 1815: 1811: 1806: 1790: 1778: 1644:sleep disorders 1604: 1589: 1576: 1573: 1509: 1505: 1501: 1482: 1477:skeletal muscle 1465:skeletal muscle 1458: 1450: 1438: 1433: 1425:tachyarrhythmia 1378:partial agonist 1373: 1368: 1342:drugs, such as 1340:anticholinergic 1337: 1310: 1301: 1289: 1287:Hyperthyroidism 1266: 1243: 1231: 1226: 1189:Hepatic disease 1089: 1083: 1080: 1037: 1035: 1021: 1009: 998: 912: 908: 893: 867: 863: 832: 748: 746:Adverse effects 718:50-metre pistol 690: 675: 662:methamphetamine 631:panic disorders 623:ureteric stones 598:aortic aneurysm 594: 578: 541:fight-or-flight 525: 509: 491: 478: 468: 464: 463: 441: 407: 398: 351:angina pectoris 300: 292: 284: 278: 274: 270: 210:, also spelled 185: 166: 160: 146: 63: 28: 23: 22: 15: 12: 11: 5: 11195: 11185: 11184: 11179: 11174: 11157: 11156: 11154: 11153: 11144: 11135: 11126: 11117: 11108: 11099: 11086: 11083: 11082: 11079: 11078: 11076: 11075: 11070: 11065: 11060: 11055: 11050: 11045: 11040: 11035: 11030: 11025: 11020: 11015: 11010: 11005: 11000: 10995: 10990: 10985: 10980: 10975: 10970: 10965: 10960: 10955: 10950: 10945: 10940: 10935: 10930: 10925: 10920: 10915: 10910: 10905: 10900: 10895: 10890: 10885: 10880: 10875: 10870: 10865: 10860: 10855: 10850: 10845: 10840: 10835: 10830: 10825: 10820: 10815: 10810: 10805: 10800: 10795: 10790: 10785: 10780: 10775: 10770: 10765: 10760: 10755: 10750: 10745: 10740: 10735: 10730: 10725: 10720: 10715: 10710: 10708:Dexpropranolol 10705: 10700: 10695: 10690: 10685: 10680: 10675: 10670: 10665: 10660: 10655: 10650: 10645: 10640: 10635: 10630: 10625: 10620: 10615: 10610: 10605: 10600: 10595: 10590: 10585: 10580: 10575: 10570: 10565: 10560: 10555: 10550: 10545: 10540: 10535: 10530: 10525: 10520: 10515: 10510: 10504: 10502: 10498: 10497: 10495: 10494: 10489: 10484: 10479: 10474: 10469: 10464: 10459: 10454: 10449: 10444: 10439: 10434: 10429: 10424: 10419: 10414: 10409: 10404: 10399: 10394: 10389: 10384: 10379: 10377:Norepinephrine 10374: 10369: 10364: 10359: 10354: 10349: 10344: 10342:Levosalbutamol 10339: 10331: 10329:-Phenylalanine 10323: 10315: 10310: 10305: 10300: 10295: 10290: 10285: 10280: 10275: 10270: 10265: 10260: 10255: 10250: 10245: 10240: 10231: 10226: 10221: 10216: 10211: 10202: 10197: 10192: 10187: 10182: 10177: 10172: 10167: 10162: 10157: 10152: 10147: 10142: 10137: 10132: 10127: 10122: 10117: 10112: 10106: 10104: 10097: 10091: 10090: 10087: 10086: 10084: 10083: 10078: 10063:chlorpromazine 10056: 10051: 10046: 10041: 10036: 10031: 10026: 10021: 10016: 10011: 10006: 10001: 9996: 9991: 9986: 9981: 9976: 9971: 9966: 9961: 9956: 9951: 9946: 9941: 9936: 9931: 9926: 9921: 9899: 9857: 9852: 9847: 9842: 9837: 9831: 9829: 9825: 9824: 9822: 9821: 9819:Xylometazoline 9816: 9811: 9806: 9801: 9796: 9791: 9786: 9781: 9776: 9771: 9766: 9761: 9756: 9751: 9746: 9741: 9736: 9731: 9729:Norepinephrine 9726: 9721: 9716: 9711: 9706: 9701: 9696: 9691: 9686: 9678: 9676:-Phenylalanine 9670: 9662: 9657: 9652: 9647: 9642: 9637: 9632: 9627: 9622: 9613: 9608: 9603: 9598: 9593: 9588: 9579: 9574: 9569: 9564: 9559: 9554: 9549: 9544: 9538: 9536: 9529: 9525: 9520: 9519: 9516: 9515: 9513: 9512: 9507: 9502: 9497: 9482:chlorpromazine 9475: 9470: 9444: 9426: 9421: 9416: 9411: 9406: 9401: 9396: 9391: 9386: 9381: 9376: 9371: 9366: 9341: 9336: 9331: 9326: 9321: 9316: 9311: 9306: 9301: 9296: 9291: 9286: 9281: 9276: 9271: 9266: 9261: 9256: 9251: 9246: 9241: 9236: 9231: 9201: 9196: 9191: 9186: 9181: 9176: 9171: 9141: 9136: 9110: 9105: 9100: 9095: 9090: 9085: 9079: 9077: 9073: 9072: 9070: 9069: 9067:Xylometazoline 9064: 9059: 9054: 9049: 9044: 9039: 9034: 9029: 9024: 9022:Norepinephrine 9019: 9014: 9009: 9004: 8999: 8994: 8989: 8981: 8979:-Phenylalanine 8973: 8965: 8960: 8955: 8950: 8945: 8940: 8935: 8930: 8921: 8916: 8911: 8906: 8901: 8892: 8887: 8882: 8877: 8872: 8866: 8864: 8857: 8853: 8848: 8847: 8837: 8836: 8829: 8822: 8814: 8805: 8804: 8802: 8801: 8796: 8791: 8781: 8776: 8770: 8768: 8764: 8763: 8761: 8760: 8755: 8745: 8740: 8735: 8721: 8710: 8708: 8704: 8697: 8696: 8694: 8693: 8688: 8683: 8678: 8673: 8668: 8663: 8657: 8655: 8649: 8648: 8646: 8645: 8640: 8630: 8625: 8611: 8605: 8603: 8590: 8589: 8586: 8585: 8583: 8582: 8577: 8571: 8566: 8557: 8552: 8546: 8544: 8538: 8537: 8535: 8534: 8529: 8523: 8521: 8514: 8513: 8511: 8510: 8505: 8499: 8497: 8488: 8482: 8481: 8479: 8478: 8473: 8468: 8463: 8453: 8447: 8445: 8439: 8438: 8421: 8420: 8413: 8406: 8398: 8389: 8388: 8385: 8384: 8383: 8382: 8379: 8368: 8362: 8356: 8355: 8352: 8351: 8348: 8347: 8345: 8344: 8322: 8295: 8293: 8277: 8276: 8274: 8273: 8268: 8262: 8260: 8251: 8244: 8243: 8240: 8239: 8236: 8235: 8232: 8231: 8229: 8228: 8222: 8220: 8214: 8213: 8211: 8210: 8205: 8200: 8195: 8190: 8185: 8179: 8177: 8172: 8164: 8160: 8159: 8156: 8155: 8153: 8152: 8146: 8144: 8138: 8137: 8135: 8134: 8129: 8124: 8122:Methoserpidine 8119: 8114: 8108: 8106: 8100: 8099: 8097: 8096: 8090: 8088: 8079: 8072: 8068: 8067: 8064: 8063: 8061: 8060: 8055: 8050: 8045: 8039: 8037: 8027: 8026: 8024: 8023: 8018: 8013: 8007: 8005: 7998: 7997: 7995: 7994: 7989: 7984: 7979: 7974: 7969: 7964: 7959: 7954: 7948: 7946: 7940: 7939: 7937: 7936: 7931: 7926: 7921: 7916: 7911: 7905: 7903: 7898: 7890: 7883: 7871:Sympatholytics 7867: 7866: 7850: 7849: 7842: 7835: 7827: 7818: 7817: 7815: 7814: 7803: 7798: 7793: 7781: 7778: 7777: 7775: 7774: 7769: 7764: 7759: 7757:Contrast media 7754: 7748: 7746: 7734: 7733: 7731: 7730: 7725: 7719: 7717: 7710:sensory organs 7706: 7705: 7703: 7702: 7697: 7693: 7688: 7683: 7677: 7675: 7662: 7661: 7659: 7658: 7653: 7648: 7643: 7638: 7633: 7628: 7623: 7618: 7609: 7608: 7607: 7602: 7597: 7587: 7582: 7577: 7572: 7567: 7562: 7557: 7555:Antipsychotics 7552: 7547: 7542: 7537: 7532: 7527: 7525:Antiaddictives 7522: 7517: 7512: 7511: 7510: 7505: 7495: 7489: 7487: 7480:nervous system 7471: 7470: 7468: 7467: 7462: 7457: 7452: 7450:Antirheumatics 7447: 7446: 7445: 7435: 7429: 7427: 7406: 7405: 7403: 7402: 7401: 7400: 7395: 7384: 7382: 7369: 7368: 7366: 7365: 7364: 7363: 7358: 7356:Antineoplastic 7353: 7348: 7343: 7332: 7330: 7317: 7316: 7314: 7313: 7308: 7303: 7302: 7301: 7296: 7291: 7289:Antiprotozoals 7284:Antiparasitics 7281: 7276: 7271: 7264:Antibacterials 7260:Antimicrobials 7256: 7254: 7230: 7229: 7227: 7226: 7217: 7212: 7211: 7210: 7205: 7195: 7189: 7187: 7174: 7173: 7171: 7170: 7165: 7160: 7155: 7149: 7147: 7134: 7133: 7131: 7130: 7125: 7123:Antipsoriatics 7120: 7115: 7110: 7104: 7102: 7091: 7090: 7088: 7087: 7086: 7085: 7080: 7075: 7065: 7064: 7063: 7058: 7053: 7051:ACE inhibitors 7041: 7036: 7031: 7026: 7021: 7016: 7015: 7014: 7009: 7004: 6990: 6988: 6979:cardiovascular 6975: 6974: 6972: 6971: 6970: 6969: 6964: 6959: 6949: 6948: 6947: 6942: 6940:Anticoagulants 6937: 6926: 6924: 6911: 6910: 6908: 6907: 6902: 6897: 6892: 6887: 6878: 6873: 6868: 6867: 6866: 6861: 6856: 6852: 6841: 6839: 6823: 6822: 6814: 6813: 6806: 6799: 6791: 6782: 6781: 6778: 6777: 6776: 6775: 6772: 6761: 6755: 6749: 6748: 6745: 6744: 6742: 6741: 6736: 6731: 6725: 6723: 6718: 6713: 6712: 6710: 6709: 6703: 6701: 6696: 6691: 6690: 6688: 6687: 6682: 6677: 6672: 6667: 6662: 6657: 6652: 6647: 6642: 6637: 6632: 6627: 6621: 6619: 6614: 6609: 6608: 6606: 6605: 6600: 6595: 6590: 6585: 6576: 6571: 6566: 6561: 6556: 6551: 6546: 6541: 6536: 6530: 6528: 6521: 6520: 6508: 6507: 6500: 6493: 6485: 6479: 6478: 6468: 6456: 6450: 6438: 6430: 6429:External links 6427: 6425: 6424: 6389: 6350: 6307: 6300: 6282: 6255:(5): 264–268. 6239: 6220:(3): 279–285. 6203: 6167: 6132:Oncoimmunology 6118: 6069: 6038:(3): 153–155. 6018: 5988: 5958: 5947:. Evaluate Ltd 5932: 5906: 5880: 5822: 5795:(3): 381–384. 5779: 5772: 5754: 5708: 5678: 5660: 5630: 5601:(1): e000010. 5581: 5554:(5): 399–404. 5538: 5505: 5472: 5442: 5423:(4): S37–S40. 5407: 5338: 5281: 5254:(4): 500–504. 5234: 5199:(2): 111–115. 5179: 5113: 5096: 5070: 5056: 5036: 5022: 5000: 4983: 4957: 4943: 4921: 4907: 4883: 4869: 4847: 4833: 4813: 4799: 4779: 4744: 4730: 4708: 4694: 4674: 4660: 4638: 4629: 4592: 4566: 4547:(2): 161–163. 4531: 4510:(1): 463–475. 4490: 4449: 4410: 4360: 4318: 4295: 4257: 4226: 4177: 4134: 4103: 4092:(2): 101–110. 4076: 4054: 4032: 3991: 3964: 3927: 3891: 3872:(3): 239–249. 3856: 3818: 3769: 3720: 3713: 3693: 3681: 3632: 3580: 3528: 3479: 3451: 3408: 3373: 3320: 3268: 3234: 3197: 3139: 3132: 3115: 3066: 3025: 2995: 2982:(6): 120–123. 2962: 2921: 2902:(2): 301–307. 2885: 2844: 2837: 2819: 2770: 2721: 2664: 2615: 2594:(4): 336–342. 2574: 2547:(6): 447–454. 2530: 2500: 2479:(6): 352–354. 2459: 2445: 2433:"Hypertension" 2418: 2404: 2377: 2356:(5): 507–520. 2336: 2286: 2284: 2281: 2280: 2279: 2274: 2269: 2264: 2259: 2257:Alpha blockers 2252: 2249: 2215: 2212: 2201: 2200: 2199: 2198: 2186: 2185: 2184: 2155: 2154: 2153: 2129: 2128: 2127: 2111: 2110: 2109: 2090: 2087: 2086: 2085: 2084: 2083: 2074: 2073: 2072: 2069: 2066: 2060: 2059: 2058: 2050: 2047: 2045: 2042: 2041: 2040: 2033: 2032:agonist agents 2029: 2025: 2022: 2021: 2020: 2013: 2009: 2006: 2005: 2004: 1999: 1992: 1988: 1985: 1980: 1977: 1976: 1971: 1966: 1961: 1955: 1950: 1945: 1940: 1929: 1925: 1909: 1905: 1901: 1897: 1894: 1893: 1892: 1887: 1881: 1875: 1869: 1863: 1858: 1854: 1848: 1844: 1838: 1833: 1829: 1823: 1813: 1809: 1805: 1802: 1789: 1786: 1776: 1622:can have both 1603: 1600: 1587: 1575: 1571: 1568: 1507: 1503: 1499: 1480: 1469:glycogenolysis 1456: 1448: 1436: 1432: 1429: 1372: 1369: 1367: 1364: 1335: 1325:Cardiac pacing 1309: 1306: 1300: 1297: 1288: 1285: 1277:glycogenolysis 1265: 1262: 1241: 1230: 1227: 1225: 1224: 1219: 1214: 1209: 1206: 1201: 1196: 1191: 1186: 1184:Kidney failure 1181: 1176: 1171: 1166: 1161: 1155: 1149: 1143: 1136: 1135: 1128: 1121: 1120: 1117: 1112: 1106: 1101: 1094: 1091: 1090: 1043:"Beta blocker" 1026:. Please help 1012: 1010: 1003: 997: 994: 986:alpha blockers 949:cardiac output 941:blood pressure 930:ACE inhibitors 910: 906: 891: 876:. This causes 865: 861: 830: 803:hallucinations 747: 744: 689: 686: 673: 593: 590: 577: 574: 524: 521: 508: 505: 489: 486:catecholamines 477: 474: 439: 406: 403: 397: 394: 386:ACE inhibitors 372:in preventing 312:smooth muscles 298: 290: 282: 276: 272: 268: 249:norepinephrine 242:catecholamines 203: 202: 196: 195: 191: 190: 183: 177: 176: 175:External links 172: 171: 158: 152: 151: 148:Best Buy Drugs 144: 138: 137: 130: 124: 123: 119: 118: 116:beta receptors 113: 107: 106: 101: 95: 94: 84: 80: 79: 76: 70: 69: 65: 64: 54: 46: 45: 37: 36: 26: 9: 6: 4: 3: 2: 11194: 11183: 11180: 11178: 11175: 11173: 11172:Beta blockers 11170: 11169: 11167: 11151: 11150: 11145: 11142: 11141: 11136: 11133: 11132: 11127: 11124: 11123: 11118: 11115: 11114: 11113:Serotonergics 11109: 11106: 11105: 11104:Dopaminergics 11100: 11097: 11096: 11093: 11088: 11087: 11084: 11074: 11071: 11069: 11066: 11064: 11061: 11059: 11056: 11054: 11051: 11049: 11046: 11044: 11041: 11039: 11036: 11034: 11031: 11029: 11026: 11024: 11021: 11019: 11016: 11014: 11011: 11009: 11006: 11004: 11001: 10999: 10996: 10994: 10991: 10989: 10986: 10984: 10981: 10979: 10976: 10974: 10971: 10969: 10966: 10964: 10961: 10959: 10956: 10954: 10951: 10949: 10946: 10944: 10941: 10939: 10936: 10934: 10931: 10929: 10926: 10924: 10921: 10919: 10916: 10914: 10911: 10909: 10906: 10904: 10901: 10899: 10896: 10894: 10891: 10889: 10886: 10884: 10881: 10879: 10876: 10874: 10871: 10869: 10866: 10864: 10861: 10859: 10858:Levobetaxolol 10856: 10854: 10851: 10849: 10846: 10844: 10841: 10839: 10836: 10834: 10831: 10829: 10826: 10824: 10821: 10819: 10816: 10814: 10811: 10809: 10806: 10804: 10801: 10799: 10796: 10794: 10791: 10789: 10786: 10784: 10781: 10779: 10776: 10774: 10771: 10769: 10766: 10764: 10761: 10759: 10756: 10754: 10751: 10749: 10746: 10744: 10741: 10739: 10736: 10734: 10731: 10729: 10726: 10724: 10721: 10719: 10716: 10714: 10711: 10709: 10706: 10704: 10701: 10699: 10698:Cyanopindolol 10696: 10694: 10691: 10689: 10686: 10684: 10681: 10679: 10676: 10674: 10671: 10669: 10666: 10664: 10661: 10659: 10656: 10654: 10651: 10649: 10646: 10644: 10641: 10639: 10636: 10634: 10631: 10629: 10626: 10624: 10621: 10619: 10616: 10614: 10611: 10609: 10606: 10604: 10601: 10599: 10596: 10594: 10591: 10589: 10586: 10584: 10581: 10579: 10576: 10574: 10571: 10569: 10566: 10564: 10561: 10559: 10556: 10554: 10551: 10549: 10546: 10544: 10541: 10539: 10536: 10534: 10531: 10529: 10526: 10524: 10521: 10519: 10516: 10514: 10511: 10509: 10506: 10505: 10503: 10499: 10493: 10490: 10488: 10485: 10483: 10480: 10478: 10475: 10473: 10470: 10468: 10465: 10463: 10460: 10458: 10455: 10453: 10450: 10448: 10445: 10443: 10440: 10438: 10435: 10433: 10430: 10428: 10425: 10423: 10420: 10418: 10415: 10413: 10410: 10408: 10405: 10403: 10400: 10398: 10395: 10393: 10390: 10388: 10385: 10383: 10382:Orciprenaline 10380: 10378: 10375: 10373: 10370: 10368: 10365: 10363: 10360: 10358: 10355: 10353: 10350: 10348: 10345: 10343: 10340: 10338: 10332: 10330: 10324: 10322: 10316: 10314: 10311: 10309: 10306: 10304: 10301: 10299: 10296: 10294: 10291: 10289: 10286: 10284: 10283:Hexoprenaline 10281: 10279: 10276: 10274: 10271: 10269: 10266: 10264: 10261: 10259: 10256: 10254: 10251: 10249: 10246: 10244: 10241: 10239: 10232: 10230: 10227: 10225: 10222: 10220: 10217: 10215: 10212: 10210: 10208: 10203: 10201: 10198: 10196: 10193: 10191: 10188: 10186: 10183: 10181: 10178: 10176: 10173: 10171: 10168: 10166: 10163: 10161: 10158: 10156: 10153: 10151: 10148: 10146: 10143: 10141: 10138: 10136: 10133: 10131: 10128: 10126: 10123: 10121: 10118: 10116: 10113: 10111: 10108: 10107: 10105: 10101: 10098: 10096: 10092: 10082: 10079: 10076: 10072: 10068: 10064: 10060: 10057: 10055: 10052: 10050: 10047: 10045: 10042: 10040: 10037: 10035: 10032: 10030: 10027: 10025: 10022: 10020: 10017: 10015: 10012: 10010: 10007: 10005: 10002: 10000: 9997: 9995: 9992: 9990: 9987: 9985: 9982: 9980: 9977: 9975: 9972: 9970: 9967: 9965: 9962: 9960: 9957: 9955: 9952: 9950: 9947: 9945: 9944:Esmirtazapine 9942: 9940: 9937: 9935: 9932: 9930: 9927: 9925: 9922: 9919: 9915: 9911: 9907: 9903: 9900: 9897: 9893: 9889: 9885: 9881: 9877: 9873: 9869: 9868:brexpiprazole 9865: 9861: 9858: 9856: 9853: 9851: 9848: 9846: 9843: 9841: 9838: 9836: 9833: 9832: 9830: 9826: 9820: 9817: 9815: 9812: 9810: 9807: 9805: 9802: 9800: 9797: 9795: 9792: 9790: 9787: 9785: 9782: 9780: 9777: 9775: 9772: 9770: 9767: 9765: 9762: 9760: 9757: 9755: 9752: 9750: 9747: 9745: 9742: 9740: 9737: 9735: 9734:Oxymetazoline 9732: 9730: 9727: 9725: 9722: 9720: 9717: 9715: 9712: 9710: 9707: 9705: 9702: 9700: 9697: 9695: 9692: 9690: 9687: 9685: 9679: 9677: 9671: 9669: 9663: 9661: 9658: 9656: 9653: 9651: 9648: 9646: 9643: 9641: 9638: 9636: 9633: 9631: 9628: 9626: 9623: 9621: 9614: 9612: 9609: 9607: 9604: 9602: 9599: 9597: 9594: 9592: 9589: 9587: 9585: 9580: 9578: 9575: 9573: 9570: 9568: 9565: 9563: 9562:Apraclonidine 9560: 9558: 9555: 9553: 9550: 9548: 9545: 9543: 9540: 9539: 9537: 9533: 9530: 9528: 9521: 9511: 9508: 9506: 9503: 9501: 9498: 9495: 9491: 9487: 9483: 9479: 9476: 9474: 9471: 9468: 9464: 9460: 9456: 9452: 9451:amitriptyline 9448: 9445: 9442: 9438: 9434: 9430: 9427: 9425: 9422: 9420: 9417: 9415: 9412: 9410: 9407: 9405: 9402: 9400: 9397: 9395: 9392: 9390: 9387: 9385: 9382: 9380: 9377: 9375: 9372: 9370: 9367: 9364: 9363:triazoledione 9360: 9356: 9352: 9348: 9345: 9342: 9340: 9337: 9335: 9332: 9330: 9327: 9325: 9322: 9320: 9317: 9315: 9312: 9310: 9307: 9305: 9302: 9300: 9297: 9295: 9292: 9290: 9287: 9285: 9282: 9280: 9277: 9275: 9272: 9270: 9267: 9265: 9262: 9260: 9257: 9255: 9252: 9250: 9247: 9245: 9242: 9240: 9237: 9235: 9232: 9229: 9225: 9221: 9217: 9213: 9209: 9205: 9202: 9200: 9197: 9195: 9192: 9190: 9187: 9185: 9182: 9180: 9177: 9175: 9172: 9169: 9165: 9161: 9157: 9153: 9149: 9145: 9144:Beta blockers 9142: 9140: 9137: 9134: 9130: 9126: 9122: 9118: 9117:brexpiprazole 9114: 9111: 9109: 9106: 9104: 9101: 9099: 9096: 9094: 9091: 9089: 9086: 9084: 9081: 9080: 9078: 9074: 9068: 9065: 9063: 9060: 9058: 9055: 9053: 9050: 9048: 9045: 9043: 9040: 9038: 9037:Phenylephrine 9035: 9033: 9032:Oxymetazoline 9030: 9028: 9025: 9023: 9020: 9018: 9015: 9013: 9010: 9008: 9005: 9003: 9000: 8998: 8995: 8993: 8990: 8988: 8982: 8980: 8974: 8972: 8966: 8964: 8963:Isometheptene 8961: 8959: 8956: 8954: 8951: 8949: 8946: 8944: 8941: 8939: 8936: 8934: 8931: 8929: 8922: 8920: 8917: 8915: 8912: 8910: 8907: 8905: 8902: 8900: 8898: 8893: 8891: 8888: 8886: 8883: 8881: 8878: 8876: 8873: 8871: 8868: 8867: 8865: 8861: 8858: 8856: 8849: 8845: 8842: 8835: 8830: 8828: 8823: 8821: 8816: 8815: 8812: 8800: 8797: 8795: 8792: 8789: 8785: 8782: 8780: 8777: 8775: 8772: 8771: 8769: 8765: 8759: 8756: 8753: 8749: 8746: 8744: 8741: 8739: 8736: 8733: 8729: 8725: 8722: 8719: 8715: 8712: 8711: 8709: 8702: 8698: 8692: 8689: 8687: 8684: 8682: 8679: 8677: 8674: 8672: 8669: 8667: 8664: 8662: 8659: 8658: 8656: 8654: 8650: 8644: 8643:Methazolamide 8641: 8638: 8634: 8631: 8629: 8628:Diclofenamide 8626: 8623: 8619: 8615: 8612: 8610: 8609:Acetazolamide 8607: 8606: 8604: 8601: 8595: 8591: 8581: 8578: 8575: 8574:Physostigmine 8572: 8570: 8567: 8565: 8561: 8558: 8556: 8553: 8551: 8548: 8547: 8545: 8543: 8539: 8533: 8530: 8528: 8527:Acetylcholine 8525: 8524: 8522: 8520: 8515: 8509: 8506: 8504: 8501: 8500: 8498: 8496: 8492: 8489: 8487: 8483: 8477: 8474: 8472: 8469: 8467: 8464: 8461: 8457: 8454: 8452: 8451:Apraclonidine 8449: 8448: 8446: 8444: 8440: 8435: 8431: 8427: 8419: 8414: 8412: 8407: 8405: 8400: 8399: 8396: 8380: 8378: 8375: 8374: 8372: 8369: 8366: 8363: 8361: 8358: 8357: 8353: 8342: 8338: 8334: 8330: 8326: 8323: 8320: 8316: 8312: 8308: 8304: 8300: 8297: 8296: 8294: 8288: 8282: 8278: 8272: 8269: 8267: 8264: 8263: 8261: 8259: 8255: 8252: 8250: 8245: 8227: 8224: 8223: 8221: 8219: 8215: 8209: 8206: 8204: 8201: 8199: 8196: 8194: 8191: 8189: 8186: 8184: 8181: 8180: 8178: 8176: 8168: 8165: 8161: 8151: 8148: 8147: 8145: 8143: 8139: 8133: 8132:Syrosingopine 8130: 8128: 8125: 8123: 8120: 8118: 8115: 8113: 8110: 8109: 8107: 8105: 8101: 8095: 8092: 8091: 8089: 8087: 8083: 8080: 8076: 8073: 8069: 8059: 8056: 8054: 8051: 8049: 8046: 8044: 8043:Hexamethonium 8041: 8040: 8038: 8036: 8032: 8028: 8022: 8019: 8017: 8014: 8012: 8009: 8008: 8006: 8003: 7999: 7993: 7990: 7988: 7985: 7983: 7980: 7978: 7975: 7973: 7970: 7968: 7965: 7963: 7960: 7958: 7955: 7953: 7950: 7949: 7947: 7945: 7941: 7935: 7932: 7930: 7927: 7925: 7922: 7920: 7917: 7915: 7912: 7910: 7907: 7906: 7904: 7902: 7894: 7891: 7887: 7884: 7881: 7877: 7872: 7868: 7863: 7859: 7855: 7854:Sympatholytic 7848: 7843: 7841: 7836: 7834: 7829: 7828: 7825: 7813: 7808: 7804: 7802: 7799: 7797: 7794: 7792: 7783: 7782: 7779: 7773: 7770: 7768: 7765: 7763: 7760: 7758: 7755: 7753: 7750: 7749: 7747: 7744: 7740: 7735: 7729: 7726: 7724: 7721: 7720: 7718: 7715: 7711: 7707: 7701: 7694: 7692: 7689: 7687: 7684: 7682: 7681:Decongestants 7679: 7678: 7676: 7673: 7669: 7663: 7657: 7654: 7652: 7649: 7647: 7644: 7642: 7639: 7637: 7634: 7632: 7629: 7627: 7624: 7622: 7619: 7617: 7613: 7610: 7606: 7603: 7601: 7600:Dissociatives 7598: 7596: 7593: 7592: 7591: 7590:Hallucinogens 7588: 7586: 7583: 7581: 7578: 7576: 7573: 7571: 7568: 7566: 7563: 7561: 7558: 7556: 7553: 7551: 7548: 7546: 7543: 7541: 7538: 7536: 7533: 7531: 7528: 7526: 7523: 7521: 7518: 7516: 7513: 7509: 7506: 7504: 7501: 7500: 7499: 7496: 7494: 7491: 7490: 7488: 7485: 7481: 7476: 7472: 7466: 7463: 7461: 7458: 7456: 7453: 7451: 7448: 7444: 7441: 7440: 7439: 7436: 7434: 7431: 7430: 7428: 7425: 7421: 7415: 7411: 7407: 7399: 7396: 7394: 7391: 7390: 7389: 7386: 7385: 7383: 7380: 7374: 7370: 7362: 7359: 7357: 7354: 7352: 7349: 7347: 7344: 7342: 7339: 7338: 7337: 7334: 7333: 7331: 7328: 7322: 7318: 7312: 7309: 7307: 7304: 7300: 7297: 7295: 7294:Anthelmintics 7292: 7290: 7287: 7286: 7285: 7282: 7280: 7277: 7275: 7272: 7269: 7265: 7261: 7258: 7257: 7255: 7252: 7248: 7244: 7240: 7235: 7231: 7225: 7221: 7218: 7216: 7213: 7209: 7206: 7204: 7201: 7200: 7199: 7196: 7194: 7191: 7190: 7188: 7185: 7181: 7175: 7169: 7166: 7164: 7161: 7159: 7156: 7154: 7151: 7150: 7148: 7145: 7141: 7138:genitourinary 7135: 7129: 7126: 7124: 7121: 7119: 7118:Antipruritics 7116: 7114: 7111: 7109: 7106: 7105: 7103: 7100: 7096: 7092: 7084: 7081: 7079: 7076: 7074: 7071: 7070: 7069: 7066: 7062: 7059: 7057: 7054: 7052: 7049: 7048: 7047: 7046: 7042: 7040: 7037: 7035: 7034:Beta blockers 7032: 7030: 7027: 7025: 7022: 7020: 7017: 7013: 7010: 7008: 7005: 7003: 7000: 6999: 6998: 6997: 6992: 6991: 6989: 6986: 6982: 6976: 6968: 6965: 6963: 6960: 6958: 6955: 6954: 6953: 6950: 6946: 6943: 6941: 6938: 6936: 6935:Antiplatelets 6933: 6932: 6931: 6928: 6927: 6925: 6922: 6916: 6912: 6906: 6903: 6901: 6898: 6896: 6893: 6891: 6888: 6886: 6882: 6879: 6877: 6874: 6872: 6869: 6865: 6862: 6860: 6853: 6851: 6848: 6847: 6846: 6843: 6842: 6840: 6837: 6833: 6828: 6824: 6820: 6812: 6807: 6805: 6800: 6798: 6793: 6792: 6789: 6773: 6771: 6768: 6767: 6765: 6762: 6759: 6756: 6754: 6751: 6750: 6746: 6740: 6737: 6735: 6732: 6730: 6727: 6726: 6724: 6721: 6714: 6708: 6705: 6704: 6702: 6699: 6692: 6686: 6683: 6681: 6678: 6676: 6673: 6671: 6668: 6666: 6663: 6661: 6658: 6656: 6653: 6651: 6648: 6646: 6643: 6641: 6638: 6636: 6633: 6631: 6628: 6626: 6623: 6622: 6620: 6617: 6610: 6604: 6601: 6599: 6596: 6594: 6591: 6589: 6586: 6584: 6580: 6577: 6575: 6572: 6570: 6567: 6565: 6562: 6560: 6557: 6555: 6552: 6550: 6547: 6545: 6542: 6540: 6537: 6535: 6532: 6531: 6529: 6526: 6522: 6517: 6513: 6512:Beta blockers 6506: 6501: 6499: 6494: 6492: 6487: 6486: 6483: 6476: 6472: 6469: 6466: 6465: 6460: 6457: 6454: 6451: 6448: 6447: 6442: 6439: 6436: 6433: 6432: 6420: 6416: 6412: 6408: 6404: 6400: 6393: 6385: 6381: 6377: 6373: 6369: 6365: 6361: 6354: 6346: 6342: 6338: 6334: 6330: 6326: 6322: 6318: 6311: 6303: 6301:9780789001344 6297: 6293: 6286: 6278: 6274: 6270: 6266: 6262: 6258: 6254: 6250: 6243: 6235: 6231: 6227: 6223: 6219: 6215: 6207: 6199: 6195: 6191: 6187: 6183: 6179: 6171: 6163: 6159: 6154: 6149: 6145: 6141: 6137: 6133: 6129: 6122: 6114: 6110: 6105: 6100: 6096: 6092: 6088: 6084: 6080: 6073: 6065: 6061: 6056: 6051: 6046: 6041: 6037: 6033: 6029: 6022: 6006: 6002: 5998: 5992: 5976: 5972: 5968: 5962: 5946: 5942: 5936: 5920: 5916: 5910: 5894: 5890: 5884: 5876: 5872: 5867: 5862: 5858: 5854: 5850: 5846: 5842: 5835: 5833: 5831: 5829: 5827: 5818: 5814: 5810: 5806: 5802: 5798: 5794: 5790: 5783: 5775: 5773:9783642742095 5769: 5765: 5758: 5750: 5746: 5741: 5736: 5732: 5728: 5724: 5717: 5715: 5713: 5696: 5692: 5688: 5682: 5674: 5670: 5664: 5648: 5644: 5640: 5634: 5626: 5622: 5617: 5612: 5608: 5604: 5600: 5596: 5592: 5585: 5577: 5573: 5569: 5565: 5561: 5557: 5553: 5549: 5542: 5526: 5522: 5518: 5512: 5510: 5493: 5489: 5485: 5479: 5477: 5460: 5456: 5452: 5446: 5438: 5434: 5430: 5426: 5422: 5418: 5411: 5395: 5391: 5387: 5381: 5379: 5377: 5375: 5373: 5371: 5369: 5367: 5365: 5363: 5361: 5359: 5357: 5355: 5353: 5351: 5349: 5347: 5345: 5343: 5334: 5330: 5325: 5320: 5316: 5312: 5308: 5304: 5300: 5296: 5292: 5285: 5277: 5273: 5269: 5265: 5261: 5257: 5253: 5249: 5245: 5238: 5230: 5226: 5222: 5218: 5214: 5210: 5206: 5202: 5198: 5194: 5190: 5183: 5175: 5171: 5166: 5161: 5156: 5151: 5147: 5143: 5139: 5132: 5130: 5128: 5126: 5124: 5122: 5120: 5118: 5106: 5100: 5084: 5080: 5074: 5059: 5053: 5049: 5048: 5040: 5025: 5019: 5015: 5011: 5004: 4997: 4990:September 10, 4986: 4980: 4976: 4971: 4970: 4961: 4946: 4940: 4936: 4932: 4925: 4910: 4904: 4900: 4899: 4894: 4893:Northridge ME 4887: 4876:September 10, 4872: 4866: 4862: 4858: 4851: 4840:September 10, 4836: 4830: 4826: 4825: 4817: 4806:September 10, 4802: 4796: 4792: 4791: 4783: 4775: 4771: 4767: 4763: 4759: 4755: 4748: 4733: 4727: 4723: 4719: 4712: 4697: 4691: 4687: 4686: 4678: 4663: 4657: 4653: 4649: 4642: 4633: 4614: 4610: 4603: 4596: 4580: 4576: 4570: 4562: 4558: 4554: 4550: 4546: 4542: 4535: 4527: 4523: 4518: 4513: 4509: 4505: 4501: 4494: 4486: 4482: 4477: 4472: 4468: 4464: 4460: 4453: 4445: 4441: 4437: 4433: 4429: 4425: 4417: 4415: 4398: 4393: 4388: 4384: 4380: 4379: 4374: 4370: 4364: 4346: 4339: 4337: 4335: 4333: 4331: 4329: 4327: 4325: 4323: 4314: 4310: 4306: 4299: 4291: 4287: 4283: 4279: 4275: 4271: 4264: 4262: 4245: 4241: 4237: 4230: 4222: 4218: 4213: 4208: 4204: 4200: 4196: 4192: 4188: 4181: 4173: 4169: 4165: 4161: 4157: 4153: 4149: 4145: 4138: 4122: 4118: 4114: 4107: 4099: 4095: 4091: 4087: 4080: 4072: 4071: 4063: 4061: 4059: 4042: 4036: 4028: 4024: 4019: 4014: 4010: 4006: 4002: 3995: 3979: 3975: 3968: 3949: 3945: 3938: 3931: 3915: 3911: 3910: 3905: 3898: 3896: 3887: 3883: 3879: 3875: 3871: 3867: 3860: 3852: 3848: 3844: 3840: 3836: 3832: 3825: 3823: 3814: 3810: 3805: 3800: 3796: 3792: 3788: 3784: 3780: 3773: 3765: 3761: 3756: 3751: 3747: 3743: 3739: 3735: 3731: 3724: 3716: 3710: 3706: 3705: 3697: 3690: 3685: 3677: 3673: 3668: 3663: 3659: 3655: 3651: 3647: 3643: 3636: 3628: 3624: 3619: 3614: 3610: 3606: 3602: 3598: 3594: 3587: 3585: 3576: 3572: 3567: 3562: 3558: 3554: 3550: 3546: 3542: 3535: 3533: 3524: 3520: 3515: 3510: 3506: 3502: 3498: 3494: 3490: 3483: 3475: 3471: 3470: 3465: 3458: 3456: 3447: 3443: 3439: 3435: 3431: 3427: 3423: 3419: 3412: 3404: 3400: 3396: 3392: 3388: 3384: 3377: 3368: 3364: 3359: 3354: 3350: 3346: 3342: 3338: 3334: 3327: 3325: 3316: 3312: 3307: 3302: 3298: 3294: 3290: 3286: 3282: 3275: 3273: 3257: 3253: 3249: 3245: 3238: 3223: 3219: 3215: 3211: 3204: 3202: 3193: 3189: 3184: 3179: 3175: 3171: 3167: 3163: 3159: 3152: 3150: 3148: 3146: 3144: 3135: 3133:9781259584732 3129: 3125: 3119: 3111: 3107: 3102: 3097: 3093: 3089: 3085: 3081: 3077: 3070: 3062: 3058: 3053: 3048: 3044: 3040: 3036: 3029: 3013: 3009: 3005: 2999: 2990: 2985: 2981: 2977: 2973: 2966: 2958: 2954: 2949: 2944: 2940: 2936: 2932: 2925: 2917: 2913: 2909: 2905: 2901: 2897: 2889: 2881: 2877: 2872: 2867: 2863: 2859: 2855: 2848: 2840: 2834: 2830: 2823: 2815: 2811: 2806: 2801: 2797: 2793: 2789: 2785: 2781: 2774: 2766: 2762: 2757: 2752: 2748: 2744: 2740: 2736: 2732: 2725: 2717: 2713: 2708: 2703: 2699: 2695: 2691: 2687: 2683: 2679: 2675: 2668: 2660: 2656: 2651: 2646: 2642: 2638: 2634: 2630: 2626: 2619: 2611: 2607: 2602: 2597: 2593: 2589: 2585: 2578: 2570: 2566: 2562: 2558: 2554: 2550: 2546: 2542: 2534: 2518: 2514: 2513:The Telegraph 2510: 2504: 2496: 2492: 2487: 2482: 2478: 2474: 2470: 2463: 2448: 2442: 2438: 2434: 2427: 2425: 2423: 2407: 2401: 2397: 2393: 2386: 2384: 2382: 2373: 2369: 2364: 2359: 2355: 2351: 2347: 2340: 2332: 2328: 2323: 2318: 2314: 2310: 2306: 2302: 2298: 2291: 2287: 2278: 2275: 2273: 2270: 2268: 2265: 2263: 2260: 2258: 2255: 2254: 2248: 2246: 2242: 2240: 2235: 2231: 2229: 2225: 2221: 2214:Other effects 2211: 2209: 2205: 2197: 2193: 2190: 2189: 2187: 2182: 2178: 2174: 2170: 2166: 2162: 2159: 2158: 2156: 2152: 2148: 2144: 2140: 2136: 2133: 2132: 2130: 2126: 2122: 2118: 2115: 2114: 2112: 2107: 2103: 2099: 2096: 2095: 2093: 2092: 2081: 2080: 2079: 2075: 2070: 2067: 2064: 2063: 2061: 2056: 2055: 2053: 2052: 2039: 2036: 2035: 2019: 2016: 2015: 2003: 2000: 1998: 1995: 1994: 1984: 1975: 1972: 1970: 1967: 1965: 1962: 1959: 1956: 1954: 1951: 1949: 1946: 1944: 1941: 1938: 1935: 1934: 1933: 1923: 1919: 1915: 1891: 1888: 1885: 1882: 1879: 1876: 1873: 1870: 1867: 1864: 1862: 1859: 1852: 1849: 1842: 1839: 1837: 1834: 1827: 1824: 1822: 1819: 1818: 1817: 1798: 1794: 1785: 1783: 1780: 1772: 1768: 1764: 1760: 1756: 1752: 1748: 1744: 1740: 1736: 1732: 1728: 1724: 1720: 1716: 1712: 1708: 1703: 1701: 1697: 1693: 1689: 1685: 1681: 1677: 1673: 1669: 1665: 1661: 1657: 1653: 1649: 1645: 1641: 1637: 1633: 1629: 1625: 1621: 1617: 1613: 1609: 1608:lipophilicity 1599: 1597: 1593: 1585: 1581: 1567: 1565: 1560: 1558: 1554: 1550: 1546: 1543: 1539: 1536:function and 1535: 1530: 1528: 1523: 1521: 1517: 1511: 1496: 1493: 1488: 1486: 1478: 1474: 1470: 1466: 1462: 1461:smooth muscle 1454: 1446: 1442: 1428: 1426: 1422: 1416: 1414: 1410: 1406: 1402: 1398: 1394: 1390: 1386: 1381: 1379: 1363: 1361: 1357: 1353: 1349: 1348:beta agonists 1345: 1341: 1332: 1330: 1326: 1322: 1318: 1314: 1305: 1296: 1294: 1293:thyroid storm 1284: 1282: 1278: 1273: 1271: 1261: 1259: 1255: 1251: 1247: 1238: 1236: 1223: 1220: 1218: 1215: 1213: 1210: 1207: 1205: 1202: 1200: 1197: 1195: 1192: 1190: 1187: 1185: 1182: 1180: 1177: 1175: 1172: 1170: 1167: 1165: 1162: 1159: 1156: 1154: 1153:heart failure 1150: 1148: 1144: 1141: 1140: 1139: 1133: 1129: 1126: 1125: 1124: 1118: 1116: 1113: 1110: 1107: 1105: 1102: 1100: 1097: 1096: 1087: 1084:November 2022 1076: 1073: 1069: 1066: 1062: 1059: 1055: 1052: 1048: 1045: –  1044: 1040: 1039:Find sources: 1033: 1029: 1025: 1019: 1018: 1017:single source 1013:This section 1011: 1007: 1002: 1001: 993: 991: 987: 983: 979: 975: 974:nitroglycerin 971: 967: 962: 958: 954: 950: 946: 942: 937: 935: 931: 927: 922: 920: 916: 904: 901: 897: 889: 885: 883: 879: 875: 871: 858: 856: 852: 848: 844: 840: 836: 828: 824: 820: 816: 812: 808: 804: 800: 796: 792: 788: 784: 783:heart failure 780: 776: 772: 768: 764: 760: 756: 752: 743: 741: 736: 733: 731: 727: 723: 719: 715: 711: 707: 703: 699: 695: 685: 683: 679: 671: 667: 663: 659: 655: 651: 647: 642: 640: 636: 632: 628: 624: 619: 617: 613: 609: 604: 601: 599: 589: 587: 583: 573: 571: 567: 566: 561: 557: 553: 549: 544: 542: 538: 534: 530: 520: 516: 512: 504: 502: 498: 493: 487: 483: 473: 460: 456: 453: 452:extracellular 449: 445: 435: 432: 428: 427:ACE inhibitor 424: 420: 416: 412: 402: 393: 391: 387: 383: 379: 375: 371: 367: 363: 362:meta-analyses 358: 356: 352: 348: 344: 340: 335: 333: 329: 325: 321: 317: 313: 309: 304: 302: 294: 286: 266: 262: 258: 254: 250: 246: 243: 240: 236: 231: 229: 225: 221: 217: 213: 209: 208:Beta blockers 201: 197: 192: 188: 184: 182: 178: 173: 169: 163: 159: 157: 153: 149: 145: 143: 139: 135: 131: 129: 125: 122:Clinical data 120: 117: 114: 112: 108: 105: 102: 100: 96: 92: 88: 85: 81: 77: 75: 71: 66: 61: 57: 52: 47: 44: 43: 38: 35:Beta blockers 33: 30: 19: 18:Beta blockers 11147: 11138: 11129: 11120: 11111: 11102: 11091: 11090: 10883:Metipranolol 10868:Levomoprolol 10813:Idropranolol 10308:Isoprenaline 10206: 10130:Arformoterol 10075:thioridazine 10067:fluphenazine 10039:Spiroxatrine 9999:Phentolamine 9918:tandospirone 9884:paliperidone 9774:Tasipimidine 9754:Rezatomidine 9699:Medetomidine 9583: 9494:thioridazine 9486:fluphenazine 9467:trimipramine 9455:clomipramine 9339:Phentolamine 9208:acetergamine 9184:Corynanthine 9143: 8896: 8788:+latanoprost 8779:Guanethidine 8767:Other agents 8681:Metipranolol 8652: 8622:+brimonidine 8614:Brinzolamide 8600:sulfonamides 8564:Fluostigmine 8324: 8303:Aprocitentan 8298: 8226:Phentolamine 8112:Bietaserpine 8058:Trimethaphan 8048:Mecamylamine 7982:Guanethidine 7962:Debrisoquine 7876:α-adrenergic 7874:(antagonize 7595:Psychedelics 7565:Aphrodisiacs 7239:infestations 7215:Sex hormones 7168:Sex hormones 7113:Cicatrizants 7043: 7033: 7029:Vasodilators 6996:antianginals 6993: 6845:stomach acid 6844: 6583:Iodopindolol 6511: 6464:The Atlantic 6462: 6444: 6402: 6398: 6392: 6367: 6363: 6353: 6320: 6310: 6291: 6285: 6252: 6248: 6242: 6217: 6213: 6206: 6181: 6177: 6170: 6135: 6131: 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Retrieved 2395: 2353: 2349: 2339: 2304: 2300: 2290: 2243: 2236: 2232: 2224:pineal gland 2217: 2202: 2151:metipranolol 2076:Agents with 1978: 1903: 1816:antagonism. 1807: 1704: 1628:side effects 1620:permeability 1605: 1577: 1561: 1531: 1527:chronotropic 1524: 1512: 1497: 1489: 1441:chronotropic 1434: 1417: 1382: 1374: 1366:Pharmacology 1360:isoprenaline 1333: 1311: 1302: 1290: 1274: 1270:hypoglycemia 1267: 1258:nonselective 1257: 1253: 1250:bronchospasm 1239: 1232: 1147:bronchospasm 1137: 1122: 1081: 1071: 1064: 1057: 1050: 1038: 1014: 990:phentolamine 970:vasodilators 938: 923: 888:Hypoglycemia 886: 882:hyperkalemia 878:hyponatremia 870:macula densa 859: 763:bronchospasm 749: 740:stage fright 737: 734: 691: 652:) caused by 643: 620: 612:hypertension 605: 602: 595: 579: 563: 556:stage fright 545: 526: 517: 513: 510: 507:Hypertension 494: 479: 461: 457: 436: 408: 399: 396:Medical uses 359: 355:pharmacology 336: 305: 232: 220:heart attack 211: 207: 206: 194:Legal status 134:Drug Classes 87:Hypertension 40: 29: 11008:Spirendolol 10983:Propranolol 10978:Propafenone 10973:Pronethalol 10863:Levobunolol 10838:Isoxaprolol 10823:Indopanolol 10808:ICI-118,551 10773:Eugenodilol 10758:Ersentilide 10738:Draquinolol 10733:Diprafenone 10703:Dalbraminol 10683:Cicloprolol 10658:Carpindolol 10643:Butofilolol 10588:Bornaprolol 10533:Alprenoxime 10501:Antagonists 10462:Tulobuterol 10457:Tretoquinol 10452:Terbutaline 10412:Ractopamine 10407:Prenalterol 10313:Isoxsuprine 10298:Indacaterol 10268:Eugenodilol 10258:Etilevodopa 10243:Epinephrine 10234:Droxidopa ( 10214:Dipivefrine 10185:Clenbuterol 10029:Setiptiline 10019:Rauwolscine 9994:Pardoprunox 9984:Mirtazapine 9949:Fenmetozole 9892:risperidone 9855:Atipamezole 9828:Antagonists 9784:Tiamenidine 9779:Tetryzoline 9759:Rilmenidine 9724:Naphazoline 9660:Guanoxabenz 9635:Epinephrine 9625:Etilevodopa 9616:Droxidopa ( 9606:Dipivefrine 9567:Brimonidine 9437:maprotiline 9314:Pardoprunox 9309:Niguldipine 9269:Mepiprazole 9244:Hydroxyzine 9234:Etoperidone 9224:nicergoline 9194:Domesticine 9189:Dapiprazole 9164:eugenodilol 9139:Benoxathian 9133:risperidone 9098:Anisodamine 9076:Antagonists 9057:Tiamenidine 9052:Tetryzoline 9017:Naphazoline 9002:Methoxamine 8997:Metaraminol 8943:Etilevodopa 8933:Epinephrine 8924:Droxidopa ( 8914:Dipivefrine 8875:Amidephrine 8774:Dapiprazole 8758:Unoprostone 8728:+netarsudil 8724:Latanoprost 8714:Bimatoprost 8676:Levobunolol 8633:Dorzolamide 8569:Neostigmine 8555:Ecothiopate 8517:muscarinic/ 8508:Pilocarpine 8476:Epinephrine 8471:Dipivefrine 8456:Brimonidine 8367:from market 8341:Sotatercept 8329:Ambrisentan 8249:antagonists 8117:Deserpidine 8053:Pentolinium 8016:Rilmenidine 7972:Guanazodine 7952:Bethanidine 7934:Tiamenidine 7924:Guanoxabenz 7728:Otologicals 7700:antagonists 7666:respiratory 7641:Orexigenics 7636:Neurotoxins 7585:Euphoriants 7575:Entactogens 7570:Depressants 7560:Anxiolytics 7498:Anesthetics 7274:Antifungals 6871:Antiemetics 6859:antagonists 6760:from market 6588:Propranolol 6405:: e17–e18. 5981:October 18, 5951:October 18, 5925:November 9, 5899:November 9, 5701:October 18, 5687:"SR 59230A" 5653:October 18, 5531:October 18, 5498:October 18, 5465:October 18, 5451:"CARTEOLOL" 4950:October 23, 4914:October 23, 4403:December 9, 4197:(7557): 8. 3789:(1): 31–9. 3783:Anesth Prog 3261:October 31, 3227:October 31, 2935:Circulation 2204:Propranolol 2196:propranolol 2169:propranolol 2143:levobunolol 2002:ICI-118,551 1821:Propranolol 1782:selectivity 1715:propranolol 1492:sympathetic 1413:bradycardia 1344:ipratropium 1281:diaphoresis 1246:β2-agonists 1160:: see below 1130:History of 1104:Hypotension 1099:Bradycardia 874:aldosterone 851:propranolol 787:heart block 779:hypotension 775:bradycardia 730:propranolol 726:Kim Jong-su 658:amphetamine 347:pronethalol 343:propranolol 339:James Black 332:epinephrine 279:receptors. 245:epinephrine 200:In Wikidata 162:MedicineNet 60:propranolol 11166:Categories 11073:Xipranolol 11063:Toliprolol 11053:Tiprenolol 11038:Tienoxolol 11033:Tertatolol 11018:Sulfinalol 10998:Soquinolol 10993:Ronactolol 10968:Procinolol 10963:Primidolol 10948:Penbutolol 10928:Pacrinolol 10923:Oxprenolol 10918:Nipradilol 10888:Metoprolol 10878:Mepindolol 10873:Medroxalol 10843:Isamoltane 10833:Iprocrolol 10793:Flusoxolol 10783:Falintolol 10763:Esatenolol 10713:Diacetolol 10693:Cloranolol 10673:Celiprolol 10668:Carvedilol 10648:Capsinolol 10633:Butaxamine 10628:Bupranolol 10618:Bunitrolol 10598:Bucindolol 10593:Brefonalol 10583:Bopindolol 10578:Bisoprolol 10573:Bevantolol 10553:Arotinolol 10538:Amosulalol 10528:Alprenolol 10508:Acebutolol 10487:Zilpaterol 10472:Vilanterol 10447:Solabegron 10442:Salmeterol 10437:Salbutamol 10422:Reproterol 10417:Procaterol 10402:Pirbuterol 10387:Oxyfedrine 10372:Mirabegron 10367:Methyldopa 10357:Melevodopa 10347:Lubabegron 10303:Isoetarine 10288:Higenamine 10278:Formoterol 10253:Etilefrine 10248:Etafedrine 10229:Dopexamine 10219:Dobutamine 10200:Denopamine 10195:Corbadrine 10175:Carmoterol 10170:Carbuterol 10160:Broxaterol 10155:Bitolterol 10145:Bambuterol 10135:Arotinolol 10125:Arbutamine 10115:Alifedrine 10110:Abediterol 10054:Tolazoline 10044:Sunepitron 10034:Spegatrine 10024:Rotigotine 9964:Ketanserin 9954:Fluparoxan 9934:Cirazoline 9929:Buflomedil 9914:ipsapirone 9902:Azapirones 9888:quetiapine 9880:olanzapine 9876:lurasidone 9850:Aptazapine 9845:Amesergide 9794:Tolonidine 9789:Tizanidine 9769:Talipexole 9764:Romifidine 9719:Moxonidine 9709:Methyldopa 9704:Melevodopa 9694:Lofexidine 9655:Guanfacine 9640:Etilefrine 9630:Ergotamine 9591:Detomidine 9577:Corbadrine 9473:Trimazosin 9463:imipramine 9424:Tolazoline 9419:Tiodazosin 9409:Tamsulosin 9404:Talipexole 9394:Spegatrine 9379:Quinazosin 9355:nefazodone 9329:Phendioxan 9319:Pelanserin 9304:Niaprazine 9299:Neldazosin 9289:Naftopidil 9284:Moxisylyte 9254:Ketanserin 9239:Fenspiride 9212:ergotamine 9174:Buflomedil 9160:carvedilol 9156:arotinolol 9152:amosulalol 9129:quetiapine 9125:olanzapine 9088:Ajmalicine 9047:Synephrine 9027:Octopamine 9007:Methyldopa 8992:Melevodopa 8958:Indanidine 8938:Etilefrine 8890:Corbadrine 8885:Cirazoline 8844:modulators 8794:Omidenepag 8784:Netarsudil 8748:Travoprost 8743:Tafluprost 8691:Mepindolol 8550:Demecarium 8503:Aceclidine 8495:muscarinic 8337:Sitaxentan 8333:+tadalafil 8315:+tadalafil 8311:Macitentan 8271:Lidanserin 8266:Ketanserin 8203:Trimazosin 8188:Ketanserin 8150:Metirosine 8071:Peripheral 8021:Tolonidine 8011:Moxonidine 7977:Guancydine 7929:Methyldopa 7919:Guanfacine 7651:Stimulants 7631:Nootropics 7605:Deliriants 7580:Entheogens 7515:Anorectics 7493:Analgesics 7346:Alkylating 7279:Antivirals 7234:infections 7108:Emollients 6962:Coagulants 6832:metabolism 6734:Carvedilol 6729:Arotinolol 6707:Butaxamine 6700:-selective 6670:Metoprolol 6650:Celiprolol 6645:Bisoprolol 6640:Bevantolol 6625:Acebutolol 6618:-selective 6598:Tertatolol 6574:Penbutolol 6569:Oxprenolol 6559:Mepindolol 6554:Cloranolol 6544:Bupranolol 6539:Bopindolol 6534:Alprenolol 5595:Open Heart 5148:(2): 155. 5029:October 7, 3248:StatPearls 3214:StatPearls 2283:References 2181:bisoprolol 2177:carvedilol 2165:metoprolol 2121:carvedilol 2117:Bisoprolol 1997:Butaxamine 1964:Metoprolol 1958:Celiprolol 1953:Bisoprolol 1937:Acebutolol 1872:Penbutolol 1866:Oxprenolol 1841:Carvedilol 1826:Bucindolol 1739:metoprolol 1735:carvedilol 1731:bisoprolol 1723:acebutolol 1707:penbutolol 1696:aggression 1652:nightmares 1640:depression 1596:arteriolar 1584:carvedilol 1559:blockade. 1534:sinus node 1409:antagonist 1401:acebutolol 1393:penbutolol 1385:oxprenolol 1356:salbutamol 1164:Bronchitis 1138:Cautions: 1054:newspapers 982:furosemide 953:metoprolol 855:metoprolol 839:Carvedilol 811:nightmares 682:carvedilol 639:anesthesia 635:withdrawal 565:The Lancet 529:anxiolytic 423:metoprolol 419:carvedilol 415:Bisoprolol 239:endogenous 216:arrhythmia 212:β-blockers 91:arrhythmia 42:Drug class 11092:See also: 11068:Xibenolol 11058:Tolamolol 11043:Tilisolol 11023:Talinolol 11013:SR 59230A 10988:Ridazolol 10958:Practolol 10938:Pamatolol 10933:Pafenolol 10913:Nifenalol 10908:Nebivolol 10903:Nadoxolol 10853:Landiolol 10848:Labetalol 10818:Indenolol 10788:Flestolol 10778:Exaprolol 10743:Ecastolol 10728:Dilevalol 10688:Cinamolol 10678:Cetamolol 10663:Carteolol 10653:Carazolol 10638:Butidrine 10613:Bufuralol 10608:Bufetolol 10603:Bucumolol 10568:Betaxolol 10563:Befunolol 10543:Ancarolol 10513:Adaprolol 10477:Xamoterol 10432:Ritodrine 10427:Rimiterol 10392:PF-610355 10352:Mabuterol 10337:-Tyrosine 10293:Ibopamine 10273:Fenoterol 10180:Cimaterol 10165:Buphenine 10150:Befunolol 10120:Amibegron 10081:Yohimbine 10049:Terguride 10014:Piribedil 10009:Piperoxan 9979:Mianserin 9924:BRL-44408 9906:buspirone 9872:clozapine 9864:asenapine 9804:Vatinoxan 9744:Piperoxan 9714:Mivazerol 9689:Ibopamine 9684:-Tyrosine 9650:Guanabenz 9572:Clonidine 9510:Zolertine 9441:mianserin 9433:amoxapine 9414:Terazosin 9399:Spiperone 9389:Silodosin 9384:Quinidine 9369:Piperoxan 9359:trazodone 9324:Perlapine 9294:Nantenine 9279:Monatepil 9274:Metazosin 9259:L-765,314 9249:Indoramin 9228:terguride 9204:Ergolines 9199:Doxazosin 9179:Bunazosin 9168:labetalol 9121:clozapine 9108:Atiprosin 9103:Anisodine 9093:Alfuzosin 9083:Abanoquil 9012:Midodrine 8987:-Tyrosine 8953:Ibopamine 8880:Buspirone 8799:Ripasudil 8671:Carteolol 8666:Betaxolol 8661:Befunolol 8532:Carbachol 8519:nicotinic 8466:Clonidine 8377:Phase III 8365:Withdrawn 8325:selective 8319:Riociguat 8193:Indoramin 8183:Doxazosin 8127:Reserpine 8094:Pargyline 7987:Guanoclor 7967:Guanadrel 7957:Bretylium 7914:Guanabenz 7909:Clonidine 7801:ATC codes 7767:Dressings 7752:Antidotes 7616:Sedatives 7612:Hypnotics 7321:malignant 7178:endocrine 7024:Diuretics 6957:Platelets 6917:and blood 6876:Laxatives 6770:Phase III 6758:Withdrawn 6739:Labetalol 6685:Talinolol 6680:Practolol 6675:Nebivolol 6665:Landiolol 6635:Betaxolol 6549:Carteolol 6337:1469-493X 6011:April 30, 5400:April 30, 5315:1550-9389 5276:250708105 5268:1573-899X 5213:0031-6970 5083:Drugs.com 5063:March 11, 4622:March 28, 4250:April 20, 4242:. WebMD. 4127:August 8, 4047:March 11, 3920:March 28, 3740:: i6112. 2698:1469-493X 2541:Angiology 2523:March 25, 2220:melatonin 2139:carteolol 2135:Betaxolol 2106:landiolol 2038:Nebivolol 2018:SR 59230A 1969:Nebivolol 1948:Betaxolol 1851:Labetalol 1836:Carteolol 1759:labetalol 1751:carteolol 1743:nebivolol 1727:betaxolol 1684:akathisia 1664:psychosis 1632:cognitive 1580:labetalol 1485:lipolysis 1445:inotropic 1397:labetalol 1254:selective 1204:Psoriasis 1179:Emphysema 1024:talk page 978:diuretics 957:labetalol 829:. Mixed α 795:dizziness 712:. In the 678:labetalol 670:ephedrine 648:(e.g. in 560:auditions 378:diuretics 337:In 1964, 310:muscles, 255:, of the 128:Drugs.com 10953:Pindolol 10943:Pargolol 10893:Moprolol 10768:Esprolol 10753:Ericolol 10748:Epanolol 10558:Atenolol 10523:Afurolol 10518:Adimolol 10492:Zinterol 10467:Vibegron 10224:Dopamine 10190:Colterol 10103:Agonists 10071:loxapine 9969:Lisuride 9959:Idazoxan 9939:Efaroxan 9910:gepirone 9896:zotepine 9840:Adimolol 9814:Xylazine 9799:Urapidil 9611:Dopamine 9535:Agonists 9500:Urapidil 9490:loxapine 9374:Prazosin 9220:lisuride 9148:adimolol 8919:Dopamine 8863:Agonists 8752:+timolol 8732:+timolol 8718:+timolol 8637:+timolol 8618:+timolol 8580:Paraoxon 8560:Stigmine 8460:+timolol 8426:glaucoma 8307:Bosentan 8208:Urapidil 8198:Prazosin 8078:Indirect 8004:agonists 7992:Guanoxan 7646:Serenics 7311:Vaccines 7078:Fibrates 6900:Vitamins 6850:Antacids 6655:Epanolol 6630:Atenolol 6579:Pindolol 6419:27531627 6345:11686955 6269:28132057 6249:Oncology 6234:24786858 6198:23942335 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Index

Beta blockers
Drug class
Propranolol
Skeletal formula
propranolol
Synonyms
Hypertension
arrhythmia
ATC code
C07
Biological target
beta receptors
Drugs.com
Drug Classes
Consumer Reports
Best Buy Drugs
WebMD
MedicineNet
RxList
MeSH
D000319
In Wikidata
arrhythmia
heart attack
secondary prevention
high blood pressure
competitive antagonists
endogenous
catecholamines
epinephrine

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