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Vasopressin

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942: 919: 564: 841: 816: 5929: 3150:) to increase the blood pressure while sparing the use of catecholamines. These argipressins have much shorter elimination half-life (around 20 minutes) comparing to synthetic non-arginine vasopresines with much longer elimination half-life of many hours. Further, argipressins act on V1a, V1b, and V2 receptors which consequently lead to higher eGFR and lower vascular resistance in the lungs. A number of injectable arginine vasopressins are currently in clinical use in the United States and in Europe. 5884: 1193: 948: 847: 724: 65: 5914: 5899: 2569: 2549: 56: 699:
InChI=1S/C46H65N15O12S2 /c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
647: 2293:), stimulates secretion, even in the face of decreased osmolality of the plasma: it supersedes osmolality, but with a milder effect. In other words, vasopressin secretion is also stimulated in the presence of hypoosmolality (hyponatremia) when the arterial blood volume is low by the unloading of 3431:
Evidence for an effect of AVP on monogamy vs polygamy comes from experimental studies in several species, which indicate that the precise distribution of vasopressin and vasopressin receptors in the brain is associated with species-typical patterns of social behavior. In particular, there are
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is very similar to that of the vasopressins: It is also a nonapeptide with a disulfide bridge and its amino acid sequence differs at only two positions. The two genes are located on the same chromosome separated by a relatively small distance of less than 15,000 bases in most species. The
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that secrete vasopressin are adjacent to magnocellular neurons that secrete oxytocin, and are similar in many respects. The similarity of the two peptides can cause some cross-reactions: oxytocin has a slight antidiuretic function, and high levels of AVP can cause uterine contractions.
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Increasing the water permeability of distal convoluted tubule (DCT) and cortical collecting tubules (CCT), as well as outer and inner medullary collecting duct (OMCD & IMCD) in the kidney, thus allowing water reabsorption and excretion of more concentrated urine, i.e.,
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of collecting tubule and collecting duct epithelial cells. Aquaporins allow water to move down their osmotic gradient and out of the nephron, increasing the amount of water re-absorbed from the filtrate (forming urine) back into the bloodstream. This effect is mediated by
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Höglund OV, Hagman R, Olsson K, Olsson U, Lagerstedt AS (October 2014). "Intraoperative changes in blood pressure, heart rate, plasma vasopressin, and urinary noradrenalin during elective ovariohysterectomy in dogs: repeatability at removal of the 1st and 2nd ovary".
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and causes the kidneys to reabsorb solute-free water and return it to the circulation from the tubules of the nephron, thus returning the tonicity of the body fluids toward normal. An incidental consequence of this renal reabsorption of water is concentrated
748:, ADH, ARVP, AVP-NPII, AVRP, VP, AVP gene, AVP (gene), Prepro-AVP-NP II, arginine vasopressin gene, vasopressin gene, prepro-arginine-vasopressin-neurophysin II gene, vasopressin-neurophysin II-copeptin, vasopressin-neurophysin 2-copeptin, prepro-AVP2 2320:
within neurosecretory granules that are found within Herring bodies, localized swellings of the axons and nerve terminals. These carry the peptide directly to the posterior pituitary gland, where it is stored until released into the blood.
3514:: When the blood flow through the juxtaglomerular apparatus decreases, blood pressure is considered low, and the adrenal cortex secretes aldosterone to increase sodium reabsorption in the collecting duct, thereby increasing blood pressure. 3374:
but also a number of other tumors. A variety of diseases affecting the brain or the lung (infections, bleeding) can be the driver behind SIADH. A number of drugs have been associated with SIADH, such as certain antidepressants
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consistent differences between monogamous species and polygamous species in the distribution of AVP receptors, and sometimes in the distribution of vasopressin-containing axons, even when closely related species are compared.
2147:. Vasopressin stimulates sodium chloride reabsorption in the thick ascending limb of the nephron by activating signaling pathways. Vasopressin increases the traffic of NKCC2 to the membrane and phosphorylates some 955: 854: 4728:
Goldmann A, Hoehne C, Fritz GA, Unger J, Ahlers O, Nachtigall I, et al. (September 2008). "Combined vs. Isoflurane/Fentanyl anesthesia for major abdominal surgery: Effects on hormones and hemodynamics".
4610:"Vasopressin stimulation of adrenocorticotropin hormone (ACTH) in humans. In vivo bioassay of corticotropin-releasing factor (CRF) which provides evidence for CRF mediation of the diurnal rhythm of ACTH" 8149: 8458: 5761:
Iovino M, Messana T, De Pergola G, Iovino E, Dicuonzo F, Guastamacchia E, et al. (2018). "The Role of Neurohypophyseal Hormones Vasopressin and Oxytocin in Neuropsychiatric Disorders".
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Decreased AVP release (neurogenic — i.e. due to alcohol intoxication or tumour) or decreased renal sensitivity to AVP (nephrogenic, i.e. by mutation of V2 receptor or AQP) leads to
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sites on the cytoplasmic N-terminal of the NKCC2 located in the membrane, increasing its activity. Increased NKCC2 activity aids in water reabsorption in the collecting duct through
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Joo KW, Jeon US, Kim GH, Park J, Oh YK, Kim YS, et al. (October 2004). "Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2".
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Wang XM, Dayanithi G, Lemos JR, Nordmann JJ, Treistman SN (November 1991). "Calcium currents and peptide release from neurohypophysial terminals are inhibited by ethanol".
8451: 3980: 2085:. Vasopressin also increases the concentration of calcium in the collecting duct cells, by episodic release from intracellular stores. Vasopressin, acting through 3469: 3363: 3358: 8546: 2185:
Recent evidence suggests that vasopressin may have analgesic effects. The analgesia effects of vasopressin were found to be dependent on both stress and sex.
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ventral forebrain regions have been shown to facilitate and coordinate reward circuits during partner preference formation, critical for pair bond formation.
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Matsukawa T, Miyamoto T (March 2011). "Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial natriuretic peptide in humans".
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Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW, Sterns RH (November 2007). "Hyponatremia treatment guidelines 2007: expert panel recommendations".
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The physiological stimulus for secretion of vasopressin is increased osmolality of the plasma, monitored by the hypothalamus. A decreased arterial
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Melville RJ, Forsling ML, Frizis HI, LeQuesne LP (December 1985). "Stimulus for vasopressin release during elective intra-abdominal operations".
2510:(AQP2) channels (water channels). This allows water to be reabsorbed down an osmotic gradient, and so the urine is more concentrated. Release of 2250:(alcohol) reduces the calcium-dependent secretion of AVP by blocking voltage-gated calcium channels in neurohypophyseal nerve terminals in rats. 9042: 8953: 8948: 8804: 8799: 7685: 3048: 5353: 8541: 8536: 4589:
Garrahy A, Thompston CJ (2019). "General Principles, Diabetes, Metabolism, Obesity, Gastrointestinal Hormones, Aging, Endocrine Toxicology".
3604: 3066: 9106: 9101: 9057: 8658: 8653: 8608: 8558: 8526: 8506: 8496: 7605: 3586: 2921: 2089:, also increases transcription of the aquaporin-2 gene, thus increasing the total number of aquaporin-2 molecules in collecting duct cells. 671: 9126: 8943: 8814: 8794: 8643: 8638: 8618: 7732: 6284: 6256: 6153: 4918:
Moran WH, Miltenberger FW, Shuayb WA, Zimmermann B (July 1964). "The Relationship of Antidiuretic Hormone Secretion to Surgical Stress".
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Baum S, Nusbaum M (March 1971). "The control of gastrointestinal hemorrhage by selective mesenteric arterial infusion of vasopressin".
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Acher R, Chauvet J (July 1995). "The neurohypophysial endocrine regulatory cascade: precursors, mediators, receptors, and effectors".
1813: 8928: 5883: 1806: 9072: 8854: 8849: 8834: 8578: 5217:"Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task" 8623: 7231: 6112: 3978: 2309: 2213: 182: 3936:
Lim MM, Young LJ (2004). "Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole".
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c1ccc(cc1)C2C(=O)N(C(=O)N(C(=O)N(CSSC(C(=O)N(C(=O)N2)Cc3ccc(cc3)O)N)C(=O)N4CCC4C(=O)N(CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
3262:, sensitivity to the drug, asthma, seizures, heart failure, a comatose state, migraine headaches, and cardiovascular disease. 9209: 9199: 6354: 5863: 5820: 5408: 5367: 5060: 4573: 4007: 3747: 3715: 3633: 5078:"Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice" 3569: 7850: 6036: 2232:
in order to reduce Per2 protein levels in the cell. At the same time, Per2 also inhibits the transcription factors for the
17: 5913: 3548: 3508:: When the atrium stretches, blood pressure is considered to be increased and sodium is excreted to lower blood pressure. 3250:
The use of lysine vasopressin is contraindicated in the presence of hypersensitivity to beef or pork proteins, increased
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There are other sources of AVP, beyond the hypothalamic magnocellular neurons. For example, AVP is also synthesized by
3407:). Finally, it can occur without a clear explanation. Hyponatremia can be treated pharmaceutically through the use of 4657:
Day TA, Sibbald JR (June 1990). "Noxious somatic stimuli excite neurosecretory vasopressin cells via A1 cell group".
2657: 2325: 691: 5898: 941: 8869: 8725: 6457: 2450: 2392: 3813:"The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior" 3732: 8973: 8678: 7725: 7595: 6880: 6031: 5168:"The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors" 3573: 3552: 3485: 3408: 2485: 2221: 2113: 2017:
and reduced urine volume. AVP released in high concentrations may also raise blood pressure by inducing moderate
918: 341: 4164:"Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC" 3111:
is used in conditions featuring low vasopressin secretion, as well as for control of bleeding (in some forms of
7178: 6780: 6563: 6186: 6122: 6016: 5826: 2494: 2086: 1932:). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the 1651: 3100:
Vasopressin has off-label uses and is used in the treatment of vasodilatory shock, gastrointestinal bleeding,
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Chapman IM, Professor of Medicine, Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital.
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Vasopressin agonists are used therapeutically in various conditions, and its long-acting synthetic analogue
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Nussey SS, Page SR, Ang VT, Jenkins JS (March 1988). "The response of plasma oxytocin to surgical stress".
3520:: In response to stretching of the right atrium wall, heart rate increases, lowering venous blood pressure. 3376: 757: 463: 9214: 7224: 7156: 6865: 6117: 6097: 2473: 543: 532: 7718: 7105: 6960: 6885: 6875: 6743: 6625: 5264:"Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules" 3505: 2259: 954: 853: 9219: 8237: 7924: 7855: 7630: 7188: 7115: 7072: 7032: 6860: 6800: 6773: 6765: 6748: 5856: 3449: 3371: 3289: 2333: 2301: 2256:
II stimulates AVP secretion, in keeping with its general pressor and pro-volumic effects on the body.
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and its synthetic version was used in human AVP deficiency, although it has been largely replaced by
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expression which is managed by major clock controlled genes. In this circadian circuit known as the
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AVP also may have a variety of neurological effects on the brain. It may influence pair-bonding in
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inhibits AVP secretion, in part by inhibiting Angiotensin II-induced stimulation of AVP secretion.
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Haas M, Glick SM (May 1978). "Radioimmunoassayable plasma vasopressin associated with surgery".
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Kanwar S, Woodman RC, Poon MC, Murohara T, Lefer AM, Davenpeck KL, et al. (October 1995).
3167: 3112: 2101: 283: 216: 9239: 8282: 8199: 7814: 7120: 7039: 6198: 5392: 5384: 5119:"Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression" 4984: 3235: 3093:
Vasopressin is used to manage anti-diuretic hormone deficiency. Vasopressin is used to treat
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depends on the mode of administration and ranges from thirty minutes to two hours. It has a
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The AVP that is measured in peripheral blood is almost all derived from secretion from the
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of ten to twenty minutes. It is widely distributed throughout the body and remains in the
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS (December 2004).
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Wiltshire T, Maixner W, Diatchenko L (December 2011). "Relax, you won't feel the pain".
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Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides
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for evaluation of surgical techniques. Plasma vasopressin concentration is elevated by
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Li C, Wang W, Summer SN, Westfall TD, Brooks DP, Falk S, et al. (February 2008).
5329: 5304: 4634: 4609: 4468: 4451: 4419: 4402: 3190:. Arginin vasopressins for use in septic shock are intended for intravenous use only. 1521: 1516: 1511: 1506: 1501: 1496: 1491: 1486: 1481: 1476: 1471: 1466: 1461: 1456: 1451: 1446: 1441: 1436: 1431: 1426: 1421: 1416: 1411: 1406: 1401: 1396: 1391: 1386: 1381: 1376: 1371: 1366: 1361: 1356: 1351: 1346: 1341: 1336: 1331: 1326: 1310: 1305: 1300: 1295: 1290: 1285: 1269: 1264: 1259: 1254: 1249: 1244: 1239: 1234: 9145: 8482: 8467: 7999: 7973: 7319: 7258: 7140: 7135: 7049: 6908: 6266: 5955: 5816: 5778: 5743: 5684: 5649: 5601: 5525: 5490: 5455: 5404: 5363: 5334: 5285: 5236: 5197: 5140: 5135: 5118: 5099: 5056: 5033: 4968: 4927: 4892: 4849: 4814: 4779: 4738: 4710: 4706: 4674: 4670: 4639: 4569: 4546: 4508: 4473: 4424: 4387: 4375: 4340: 4283: 4278: 4261: 4242: 4193: 4144: 4103: 4062: 4013: 4003: 3953: 3918: 3891: 3842: 3785: 3743: 3711: 3680: 3629: 3517: 2523: 2490: 2105: 737: 223: 5696: 5537: 5303:
Kaufmann JE, Oksche A, Wollheim CB, Günther G, Rosenthal W, Vischer UM (July 2000).
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effects on pain perception and cognitive function. Vasopressin also plays a role in
8696: 8403: 8360: 8154: 7741: 7161: 6903: 6829: 6796: 6233: 6228: 5790: 5770: 5733: 5723: 5712:"A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin" 5676: 5641: 5593: 5517: 5482: 5445: 5437: 5396: 5324: 5316: 5275: 5228: 5187: 5179: 5130: 5089: 5023: 5015: 4980: 4958: 4884: 4841: 4806: 4769: 4702: 4666: 4629: 4621: 4538: 4485: 4463: 4414: 4367: 4330: 4322: 4295: 4273: 4232: 4224: 4183: 4175: 4134: 4093: 4052: 4044: 3945: 3881: 3873: 3832: 3824: 3777: 3670: 3662: 3453: 3239: 2833: 2419: 2236:
gene in order to regulate its expression, the expression of vasopressin, and other
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American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM (January 1999).
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Costa A, Rossi E, Scicchitano BM, Coletti D, Moresi V, Adamo S (September 2014).
3828: 3293: 3281: 3124: 2588:(nonapeptides). The amino acid sequence of arginine vasopressin (argipressin) is 2500: 2464: 2353: 2349: 2329: 2317: 2136: 2104:
as it travels down the concentration gradient created by removing water from the
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Increasing permeability of the inner medullary portion of the collecting duct to
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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synergistically with CRH to produce ACTH (by itself it is a weak secretagogue).
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Gutt CN, Oniu T, Mehrabi A, Schemmer P, Kashfi A, Kraus T, et al. (2004).
4542: 3311: 3303: 3271: 3255: 3147: 2629: 2072:. This occurs through increased transcription and insertion of water channels ( 1979: 1953: 1110: 6491: 5117:
Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu SB, Young WS (August 2007).
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of the kidneys (especially the cortical and outer medullary collecting ducts)
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This article is about the natural peptide in humans. For the medication, see
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cysteine-type endopeptidase inhibitor activity involved in apoptotic process
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Collège des enseignants d'endocrinologie, diabète et maladie (2012-01-30).
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related to low levels of antidiuretic hormone. It is available as Pressyn.
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and some related animals, whereas arginine vasopressin is found in humans.
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of body fluids. It is released from the posterior pituitary in response to
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Lolait SJ, Stewart LQ, Jessop DS, Young WS, O'Carroll AM (February 2007).
4947:"Circulatory and respiratory complications of carbon dioxide insufflation" 4896: 4853: 4783: 4678: 4643: 4512: 4477: 4428: 4287: 4162:
Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V (January 2013).
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secretion in response to stress; social interpretation of olfactory cues
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A third function is possible. Some AVP may be released directly into the
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Forsling ML, Montgomery H, Halpin D, Windle RJ, Treacher DF (May 1998).
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Vasopressin released from posterior pituitary is associated with nausea.
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Young LJ (October 2009). "The neuroendocrinology of the social brain".
4774: 4757: 3523: 3396: 3346: 3285: 3231: 3011: 3007: 2872: 2673: 2605: 2585: 2568: 2557: 2515: 2304:(except in cases of AVP-secreting tumours). Vasopressin is produced by 1901: 926: 823: 773: 619: 443: 8204: 7690: 6795: 4963: 4946: 4625: 2548: 55: 9067: 9027: 9002: 8913: 8893: 8819: 8769: 8744: 8706: 8691: 8668: 8648: 8633: 8628: 8613: 8603: 8551: 8521: 8273: 8077: 7983: 7896: 7615: 7600: 7446: 7436: 7419: 7276: 7054: 6518: 6447: 6329: 6241: 6176: 6102: 5597: 3441: 3227: 3207: 3199: 3175: 2988: 2908: 2864: 2774: 2753: 2734: 2716: 2601: 2552:
Chemical structure of the arginine vasopressin (argipressin) with an
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Alberts B, Bray D, Hopkin K, Johnson AD, Lewis J, Roberts K (2014).
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Transactions of the American Clinical and Climatological Association
3651:"Vasopressin and oxytocin gene expression in the human hypothalamus" 9012: 8839: 8779: 8673: 8591: 8568: 8531: 8194: 8058: 7963: 7774: 7590: 7569: 7564: 7508: 6669: 6568: 6550: 6508: 6486: 6409: 6401: 6382: 6364: 6293: 6171: 6064: 6026: 5004:"The physiologic effects of pneumoperitoneum in the morbidly obese" 4121:
Knepper MA, Kim GH, Fernández-Llama P, Ecelbarger CA (March 1999).
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The most common side effects during treatment with vasopressin are
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in place of the arginine as the eighth amino acid, and is found in
2617: 2609: 2593: 2589: 2573: 2553: 2427: 2423: 2265: 2206: 2200: 2028:. The high-density distributions of vasopressin receptor AVPr1a in 2005: 1925: 1894: 1837: 492: 423: 251: 134:
Antidiuretic hormone (ADH); arginine vasopressin (AVP); argipressin
4756:
Furuya K, Shimizu R, Hirabayashi Y, Ishii R, Fukuda H (May 1993).
646: 9141: 8997: 8923: 8809: 8563: 8394: 8310: 7906: 7891: 7881: 7871: 7824: 7794: 7635: 7620: 7240: 7000: 6573: 6540: 6535: 6527: 6414: 6349: 6220: 5978: 5621: 5076:
Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ (March 2004).
4917: 3419:
Vasopressin was elucidated and synthesized for the first time by
3307: 3299: 3053: 2860: 2813: 2730: 2621: 2613: 2581: 2459: 2401: 2247: 1941: 1898: 1890: 1663: 1618: 1536: 1532: 658: 230: 8466: 3768:
Babar SM (October 2013). "SIADH associated with ciprofloxacin".
3733:"Oxytocin and Vasopressin: Genetics and Behavioral Implications" 3391:(used to induce and stimulate labor), and the chemotherapy drug 3364:
Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH)
2167:
Vasopressin released within the brain may have several actions:
1337:
negative regulation of release of cytochrome c from mitochondria
761: 8829: 7901: 7829: 7556: 6697: 6659: 6478: 6419: 3649:
Sukhov RR, Walker LC, Rance NE, Price DL, Young WS 3rd (1993).
3445: 3367: 3338: 3211: 3203: 3187: 3138:
patients not responding to fluid resuscitation or infusions of
3134:
Vasopressin infusions are also used as second line therapy for
2970: 2703: 2641: 2561: 2410: 2148: 2120: 1905: 1821: 1573: 523: 303: 268: 5841: 5355:
Tietz Textbook of Clinical Chemistry and Molecular Diagnostics
4874: 4608:
Salata RA, Jarrett DB, Verbalis JG, Robinson AG (March 1988).
4259: 1201: 8123: 7929: 7469: 7198: 6965: 6809: 6730: 6705: 6616: 6588: 6321: 5760: 5302: 5214: 5116: 4755: 4607: 4123:"Regulation of thick ascending limb transport by vasopressin" 3366:
in turn can be caused by a number of problems. Some forms of
3219: 3183: 3019: 2942: 2665:
Comparison of vasopressin and oxytocin neuropeptide families:
2468: 2414: 2406: 2343: 2229: 2225: 2025: 2014: 1960: 637: 503: 299: 264: 3859: 3317:
vasopressor effect may be higher with the concurrent use of
548: 7130: 5947: 5389:
Scientific Foundations of Biochemistry in Clinical Practice
4213:"Molecular regulation of NKCC2 in the thick ascending limb" 2890: 2856: 2217: 2093: 1913: 483: 109: 97: 91: 4498: 4357: 1985:
It has a very short half-life, between 16 and 24 minutes.
1422:
positive regulation of cytosolic calcium ion concentration
7695: 5426:"Molecular mechanisms of antidiuretic effect of oxytocin" 5261: 4691: 4501:
The Journal of Pharmacology and Experimental Therapeutics
4311:"What Is Nausea? A Historical Analysis of Changing Views" 3251: 2722: 2645: 2048: 1963:
from the hypothalamus, and may play an important role in
1462:
positive regulation of prostaglandin biosynthetic process
115: 5892:: DES 1-6 BOVINE NEUROPHYSIN II COMPLEX WITH VASOPRESSIN 5763:
Endocrine, Metabolic & Immune Disorders Drug Targets
5165: 5050: 4727: 3470:
Syndrome of inappropriate antidiuretic hormone secretion
3359:
Syndrome of inappropriate antidiuretic hormone secretion
3127:
in certain conditions. Use of vasopressin analogues for
2143:
The hormone vasopressin also stimulates the activity of
1924:
into the circulation in response to extracellular fluid
1017: 5075: 4944: 2560:
position. Lysine vasopressin differs only in having a
2224:. Per2 subsequently inhibits the transcription factors 1978:
Vasopressin induces differentiation of stem cells into
1417:
positive regulation of systemic arterial blood pressure
4449: 3648: 1372:
positive regulation of peptidyl-serine phosphorylation
5996: 4566:
Endocrinologie, diabétologie et maladies métaboliques
4161: 2543: 2243:
Many factors influence the secretion of vasopressin:
2131:
which aids in proper water reabsorption later in the
1182: 118: 112: 94: 85: 5709: 5423: 4831: 4030: 3742:(3rd ed.). Berlin: Springer. pp. 573–607. 3730: 2576:. Differs from AVP at only the 3rd and 8th position. 1912:, and is converted to AVP. It then travels down the 1522:
negative regulation of transmission of nerve impulse
1442:
positive regulation of cell population proliferation
106: 103: 88: 4082:"Regulation of renal urea transport by vasopressin" 411: 100: 27:
Mammalian hormone released from the pituitary gland
5351: 3565: 3563: 3561: 3544: 3542: 3540: 3119:) and in extreme cases of bedwetting by children. 8328: 4528: 3908: 2316:(SON). It then travels down the axon through the 964: 863: 9191: 4588: 4210: 4079: 3724: 391: 8348: 8272: 8132: 5617: 5615: 4211:Ares GR, Caceres PS, Ortiz PA (December 2011). 4033:"Vasopressin and the Regulation of Aquaporin-2" 3558: 3537: 2336:to the anterior pituitary, where it stimulates 366: 7686:Pituitary adenylate cyclase-activating peptide 5472: 4002:(Third ed.). Philadelphia, PA: Elsevier. 3570:GRCm38: Ensembl release 89: ENSMUSG00000037727 2933:Cys-Tyr-Ile-Asn/Gln-Asn-Cys-Pro-Leu/Val-Gly-NH 2159:channels by creating a hypo-osmotic filtrate. 2100:, which facilitates its reabsorption into the 2063:Vasopressin has three main effects which are: 1367:generation of precursor metabolites and energy 8452: 7726: 7606:Cocaine- and amphetamine-regulated transcript 7225: 6781: 5963: 5922:: BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN 5857: 5808: 5430:Journal of the American Society of Nephrology 4127:Journal of the American Society of Nephrology 3997: 2499:Basolateral membrane of the cells lining the 2348:Vasopressin concentration is used to measure 2220:protein accumulates and is phosphorylated by 2096:by regulating the cell surface expression of 5754: 5703: 5612: 5555: 5553: 5551: 5549: 5547: 5507: 5466: 5417: 5296: 5208: 5159: 5110: 5069: 4524: 4522: 4351: 4204: 4155: 4114: 4073: 2328:of the PVN, transported and released at the 2171:Vasopressin is released into the brain in a 1467:positive regulation of cellular pH reduction 1407:G protein-coupled receptor signaling pathway 7239: 5583: 5577: 5255: 5001: 4601: 3763: 3761: 3759: 3549:GRCh38: Ensembl release 89: ENSG00000101200 2272: 2268:inhibits secretion of antidiuretic hormone. 349:1-{carbonyl}-L-p rolyl-L-arginylglycinamide 8459: 8445: 8265: 7733: 7719: 7232: 7218: 6788: 6774: 5970: 5956: 5864: 5850: 5710:Mavani GP, DeVita MV, Michelis MF (2015). 4656: 4302: 4031:Wilson JL, Miranda CA, Knepper MA (2013). 3853: 3642: 2364:Types of AVP receptors and their actions: 2344:Vasopressin during surgery and anaesthesia 1517:multicellular organismal water homeostasis 1447:positive regulation of glutamate secretion 562: 451: 43:generally, of which it is but one example. 8382: 5737: 5727: 5660: 5635: 5544: 5449: 5382: 5328: 5279: 5191: 5134: 5093: 5027: 4962: 4796: 4773: 4633: 4519: 4467: 4418: 4334: 4308: 4277: 4236: 4187: 4138: 4097: 4056: 3929: 3885: 3866:European Journal of Translational Myology 3836: 3674: 2636:-terminus of the sequence converted to a 2162: 1427:negative regulation of female receptivity 1402:regulation of signaling receptor activity 471: 5907:: UNCOMPLEXED DES 1-6 BOVINE NEUROPHYSIN 5815:(7th ed.). Philadelphia: Saunders. 5352:Burtis CA, Ashwood ER, Bruns DE (2012). 3935: 3756: 3710:. Glenview, IL: Pearson Education, Inc. 3625:Dorland's Illustrated Medical Dictionary 3621: 3234:. The most severe adverse reactions are 2640:. Lysine vasopressin (lypressin) has a 2567: 2547: 1357:negative regulation of apoptotic process 3615: 3158:Vasopressin is administered through an 2628:, with the cysteine residues forming a 2310:paraventricular nucleus of hypothalamus 2214:transcription-translation feedback loop 1982:and promotes heart muscle homeostasis. 1512:positive regulation of vasoconstriction 1121:paraventricular nucleus of hypothalamus 558: 431: 183:paraventricular nucleus of hypothalamus 14: 9192: 4403:"Molecular bases for circadian clocks" 4400: 4080:Sands JM, Blount MA, Klein JD (2011). 3909:Cuzzo B, Padala SA, Lappin SL (2024). 3705: 3060:Cys-Phe-Trp-Thr-Ser-Cys-Pro-Ile-Gly-NH 3042:Cys-Tyr-Phe-Arg-Asn-Cys-Pro-Ile-Gly-NH 3026:Cys-Ile-Ile-Arg-Asn-Cys-Pro-Arg-Gly-NH 2995:Cys-Phe-Ile-Arg-Asn-Cys-Pro-Lys-Gly-NH 2977:Cys-Phe-Val-Arg-Asn-Cys-Pro-Thr-Gly-NH 2959:Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH 2915:Cys-Tyr-Ile-Ser-Asn-Cys-Pro-Gln-Gly-NH 2897:Cys-Tyr-Ile-Ser-Asn-Cys-Pro-Ile-Gly-NH 2879:Cys-Tyr-Ile-Gln-Ser-Cys-Pro-Ile-Gly-NH 2844:Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Ile-Gly-NH 2820:Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Pro-Gly-NH 2741:Cys-Phe-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH 2710:Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH 1377:positive regulation of gene expression 8440: 7740: 7714: 7213: 6769: 5951: 5845: 5666: 5475:Nephrology, Dialysis, Transplantation 5309:The Journal of Clinical Investigation 5002:Nguyen NT, Wolfe BM (February 2005). 4614:The Journal of Clinical Investigation 3810: 3767: 3699: 969: 930: 925: 868: 827: 822: 531: 511: 4811:10.1001/archsurg.1978.01370170059011 4037:Clinical and Experimental Nephrology 3998:Boron WR, Boulpaep EL (2016-05-05). 3245: 2438:; social recognition, circadian tau 2332:, from which it travels through the 2326:parvocellular neurosecretory neurons 2306:magnocellular neurosecretory neurons 1975:, and maternal responses to stress. 1487:regulation of renal sodium excretion 151: 3395:. It has also been associated with 3274:- may lower the antidiuretic effect 3153: 1452:response to organic cyclic compound 491: 382: 24: 5801: 5401:10.1016/B978-0-7506-0167-2.50010-8 5387:. In Williams DL, Marks V (eds.). 5385:"Polyuria and Disorders of Thirst" 5020:10.1097/01.sla.0000151791.93571.70 4846:10.1111/j.1365-2265.1988.tb01213.x 4659:The American Journal of Physiology 4591:Encyclopedia of Endocrine Diseases 3950:10.1016/j.neuroscience.2003.12.008 3731:Caldwell HK, Young WS III (2006). 3226:, pounding sensation in the head, 3123:and related analogues are used as 2544:Structure and relation to oxytocin 2194: 1457:positive regulation of cell growth 25: 9256: 5812:Brenner & Rector's the kidney 5775:10.2174/1871530318666180220104900 3426: 3314:may lower the antidiuretic effect 1250:neurohypophyseal hormone activity 6458:5-Methoxy-N,N-dimethyltryptamine 5927: 5912: 5897: 5882: 5624:The American Journal of Medicine 5136:10.1111/j.1601-183X.2006.00281.x 4707:10.1111/j.1532-950X.2014.12264.x 4671:10.1152/ajpregu.1990.258.6.R1516 4279:10.1113/expphysiol.1998.sp004124 4043:(6): 10.1007/s10157-013–0789-5. 3655:Journal of Comparative Neurology 3486:Vasopressin receptor antagonists 3435: 3409:vasopressin receptor antagonists 3206:, chest pain, abdominal cramps, 2123:absorption across the ascending 1296:clathrin-coated vesicle membrane 1265:V1B vasopressin receptor binding 1260:V1A vasopressin receptor binding 1191: 953: 946: 940: 917: 852: 845: 839: 814: 722: 597: 591: 81: 63: 54: 7596:Calcitonin gene-related peptide 5871: 5669:Frontiers in Neuroendocrinology 5510:Frontiers in Neuroendocrinology 5501: 5376: 5345: 5044: 4995: 4938: 4911: 4868: 4825: 4790: 4762:Canadian Journal of Anaesthesia 4749: 4721: 4685: 4650: 4582: 4557: 4492: 4443: 4394: 4253: 4024: 3991: 3972: 3902: 3804: 3345:(excess urine production), and 3319:ganglionic blocking medications 3265: 3193: 2114:outer medullary collecting duct 704:Key:KBZOIRJILGZLEJ-LGYYRGKSSA-N 7979:Norepinephrine (noradrenaline) 7179:Fractional excretion of sodium 5809:Rector FC, Brenner BM (2004). 4877:The British Journal of Surgery 3597: 3579: 3370:can cause SIADH, particularly 3104:and ventricular fibrillation. 3082: 1950:peripheral vascular resistance 1492:hyperosmotic salinity response 1202:More reference expression data 1171:More reference expression data 609: 603: 585: 13: 1: 9225:Vasopressin receptor agonists 5281:10.1182/blood.V86.7.2760.2760 4469:10.1016/s0092-8674(00)80959-9 4420:10.1016/s0092-8674(00)80566-8 4217:Am. J. Physiol. Renal Physiol 3770:The Annals of Pharmacotherapy 3738:. In Lajtha A, Lim R (eds.). 3530: 3377:serotonin reuptake inhibitors 3324: 3296:may raise the diuretic effect 2189: 2129:countercurrent multiplication 1988: 1270:neuropeptide hormone activity 938: 837: 9210:Posterior pituitary hormones 9200:Genes on human chromosome 20 7611:Delta-sleep-inducing peptide 5977: 5646:10.1016/j.amjmed.2007.09.001 4327:10.1016/j.autneu.2016.07.003 4180:10.1016/j.ajpath.2012.09.014 3981:"Central Diabetes Insipidus" 3829:10.1016/j.neuron.2010.03.005 2668: 2430:aggregation, and release of 2359: 2205:Vasopressin is regulated by 1412:maternal aggressive behavior 7: 7157:Effective renal plasma flow 7001:Intracellular fluid/Cytosol 5681:10.1016/j.yfrne.2009.06.002 5233:10.1016/j.yhbeh.2004.07.004 4229:10.1152/ajprenal.00396.2011 3628:(32nd ed.). Elsevier. 3463: 2474:Adrenocorticotropic hormone 2047:, has the same function in 2004:Vasopressin regulates the 1999: 1145:nucleus of stria terminalis 10: 9261: 7106:Glomerular filtration rate 7098:Assessment and measurement 6961:Atrial natriuretic peptide 6626:Insulin-like growth factor 5566:. F.A. Davis Company. 2017 4543:10.1152/ajpregu.00324.2010 4401:Dunlap JC (January 1999). 3506:Atrial natriuretic peptide 3414: 3356: 3230:, sweating, paleness, and 3086: 2786:Vertebrate Oxytocin Family 2534:"-vaptan" diuretics, i.e. 2514:and surface expression of 2413:, peripheral vasculature, 2260:Atrial natriuretic peptide 2198: 2035:A very similar substance, 1992: 1362:protein kinase C signaling 1255:signaling receptor binding 575:Chemical and physical data 38: 31: 9159: 9086: 9028:Vasotocin (argiprestocin) 9023:Vasopressin (argipressin) 8972: 8914:Vasotocin (argiprestocin) 8909:Vasopressin (argipressin) 8868: 8770:Vasotocin (argiprestocin) 8765:Vasopressin (argipressin) 8724: 8715: 8552:Vasotocin (argiprestocin) 8481: 8321: 8309: 8255: 8232: 8223: 8122: 8099: 8090: 8070: 7992: 7951: 7942: 7915: 7864: 7838: 7785:Glutamic acid (glutamate) 7780:Aspartic acid (aspartate) 7767: 7758: 7748: 7631:Gastrin-releasing peptide 7578: 7555: 7524: 7468: 7459: 7402: 7379: 7351: 7328: 7275: 7266: 7251: 7189:Tubuloglomerular feedback 7171: 7116:Augmented renal clearance 7096: 7073:Bicarbonate buffer system 7031: 6989: 6943: 6936: 6894: 6848: 6817: 6807: 6797:Physiology of the kidneys 6729: 6696: 6678: 6650: 6615: 6587: 6549: 6526: 6517: 6477: 6470: 6438: 6400: 6363: 6320: 6292: 6283: 6265: 6219: 6152: 6078: 6055: 6007: 5985: 5877: 5123:Genes, Brain and Behavior 4049:10.1007/s10157-013-0789-5 3917:. StatPearls Publishing. 3911:"Physiology, Vasopressin" 3605:"Mouse PubMed Reference:" 3587:"Human PubMed Reference:" 3450:major depressive disorder 3381:tricyclic antidepressants 3372:small cell lung carcinoma 3352: 3290:tricyclic antidepressants 3186:and excreted through the 3075: 3006:Geography & imperial 2948: 2784: 2671: 2334:hypophyseal portal system 2302:posterior pituitary gland 2058: 1944:. Second, AVP constricts 1936:from the filtrate in the 1852: 1847: 1843: 1836: 1820: 1814:Chr 2: 130.42 – 130.42 Mb 1801: 1786: 1782: 1765: 1761: 1754: 1739: 1735: 1718: 1714: 1707: 1694: 1690: 1675: 1671: 1662: 1649: 1645: 1630: 1626: 1617: 1604: 1600: 1585: 1581: 1572: 1557: 1550: 1546: 1530: 1220: 1216: 1199: 1190: 1181: 1168: 1117: 1108: 1055: 1046: 1016: 1008: 1004: 987: 974: 937: 916: 907: 903: 886: 873: 836: 813: 804: 800: 755: 752: 742: 735: 730: 721: 716: 687: 667: 657: 635: 618: 579: 574: 542: 522: 502: 482: 462: 442: 422: 402: 377: 357: 337: 332: 322: 309: 292: 282: 274: 257: 245: 229: 196: 188: 171: 163: 138: 130: 76: 71: 62: 53: 7969:Epinephrine (adrenaline) 7078:Respiratory compensation 6835:Clearance of medications 5360:Elsevier Health Sciences 3782:10.1177/1060028013502457 3708:Anatomy & physiology 3512:Renin-angiotensin system 3333:, a condition featuring 3182:. It is degraded by the 3089:Vasopressin (medication) 2281:, (such as can occur in 2273:Production and secretion 2110:cortical collecting duct 1472:response to testosterone 1063:internal globus pallidus 39:Not to be confused with 34:Vasopressin (medication) 7184:BUN-to-creatinine ratio 6919:Countercurrent exchange 5729:10.3389/fmed.2015.00019 5082:Neuropsychopharmacology 4731:Medical Science Monitor 4266:Experimental Physiology 3811:Insel TR (March 2010). 3164:intramuscular injection 3102:ventricular tachycardia 2374:Second messenger system 2177:suprachiasmatic nucleus 1920:, and is released from 1382:renal water homeostasis 1235:protein kinase activity 1141:suprachiasmatic nucleus 8944:ORG-52186 (SCH-740935) 8666:Catabolism inhibitors: 8404:Carbonyl sulfide (COS) 8005:N-Methylphenethylamine 7681:Pancreatic polypeptide 6453:N,N-Dimethyltryptamine 6430:Pancreatic polypeptide 5522:10.1006/frne.1995.1009 5442:10.1681/ASN.2007010029 5095:10.1038/sj.npp.1300360 5053:Essential Cell Biology 4889:10.1002/bjs.1800721215 4834:Clinical Endocrinology 3987:. Merck & Co. Inc. 3878:10.4081/bam.2014.3.217 3440:Vasopressin has shown 3383:), the anticonvulsant 3168:subcutaneous injection 3113:von Willebrand disease 2577: 2572:Chemical structure of 2565: 2518:through exocytosis of 2163:Central nervous system 2102:medullary interstitium 1807:Chr 20: 3.08 – 3.08 Mb 8145:2-AGE (noladin ether) 7121:Renal clearance ratio 7040:Darrow Yannet diagram 5716:Frontiers in Medicine 5630:(11 Suppl 1): S1–21. 5393:Butterworth-Heinemann 5221:Hormones and Behavior 3667:10.1002/cne.903370210 3236:myocardial infarction 2855:Most marsupials, all 2658:magnocellular neurons 2580:The vasopressins are 2571: 2551: 2512:von Willebrand factor 2436:von Willebrand factor 2199:Further information: 1993:Further information: 1893:synthesized from the 1397:membrane organization 1342:ERK1 and ERK2 cascade 830:Chromosome 20 (human) 298:Predominantly in the 263:Predominantly in the 8472:vasopressin receptor 8356:Carbon monoxide (CO) 7626:Galanin-like peptide 7146:Hemodialysis product 7126:Urea reduction ratio 7111:Creatinine clearance 6951:Antidiuretic hormone 6801:acid–base physiology 5383:Donaldson D (1994). 5184:10.1210/en.2006-1309 4665:(6 Pt 2): R1516-20. 4309:Magtanong E (2017). 3622:Anderson DA (2012). 3481:Vasopressin receptor 2838:northern tree shrews 2520:Weibel-Palade bodies 2456:Phosphatidylinositol 2398:Phosphatidylinositol 1952:and raises arterial 1879:arginine vasopressin 1871:antidiuretic hormone 1477:response to nicotine 1286:extracellular region 1153:lateral hypothalamus 1149:ventromedial nucleus 1095:right adrenal cortex 971:2 F1|2 63.24 cM 932:Chromosome 2 (mouse) 18:Arginine vasopressin 8674:Bestatin (ubenimex) 8361:Hydrogen sulfide (H 8215:Virodhamine (O-AEA) 7022:Transcellular fluid 7006:Extracellular fluid 6924:Filtration fraction 6739:Natriuretic peptide 6057:Posterior pituitary 6042:Somatostatin (GHIH) 5395:. pp. 76–102. 5055:. Garland Science. 4799:Archives of Surgery 4568:. Elsevier Masson. 4360:Nature Neuroscience 4140:10.1681/ASN.V103628 3421:Vincent du Vigneaud 3180:extracellular fluid 3131:commenced in 1970. 3037:Striped cone snail 2584:consisting of nine 2338:corticotropic cells 2127:. This adds to the 1918:posterior pituitary 1916:terminating in the 1507:response to ethanol 1437:locomotory behavior 1387:signal transduction 1352:cell-cell signaling 1301:extracellular space 50: 9215:Neuroendocrinology 8418:Sulfur dioxide (SO 8329:Cholinergic system 8031:Phenylethanolamine 8010:N-Methyltryptamine 7974:NAS (normelatonin) 7761:inhibitory systems 7759:Major excitatory / 7083:Renal compensation 7012:Interstitial fluid 6080:Anterior pituitary 5487:10.1093/ndt/gfh413 4775:10.1007/BF03009513 4695:Veterinary Surgery 4000:Medical Physiology 3496:Anterior pituitary 3331:diabetes insipidus 3224:water intoxication 3172:duration of action 3160:intravenous device 3129:esophageal varices 3095:diabetes insipidus 2676:Vasopressin Family 2578: 2566: 2314:supraoptic nucleus 2175:by neurons of the 2119:Acute increase of 2037:lysine vasopressin 1948:, which increases 1652:ENSMUSG00000037727 1320:Biological process 1279:Cellular component 1228:Molecular function 1125:supraoptic nucleus 1091:anterior pituitary 179:Supraoptic nucleus 46: 9187: 9186: 9167:Carrier proteins: 9155: 9154: 9146:lithium carbonate 9134:Other inhibitors: 8686: 8542:PF-06655075 (PF1) 8434: 8433: 8430: 8429: 8378: 8377: 8370:Nitric oxide (NO) 8344: 8343: 8317: 8305: 8304: 8301: 8300: 8251: 8250: 8247: 8246: 8118: 8117: 8114: 8113: 8086: 8085: 8000:3-Iodothyronamine 7938: 7937: 7742:Neurotransmitters 7708: 7707: 7704: 7703: 7455: 7454: 7207: 7206: 7141:Dialysis adequacy 7136:Standardized Kt/V 7092: 7091: 7050:Davenport diagram 7033:Acid–base balance 6932: 6931: 6909:Renal plasma flow 6763: 6762: 6759: 6758: 6646: 6645: 6466: 6465: 6396: 6395: 6148: 6147: 5945: 5944: 5822:978-0-7216-0164-9 5410:978-0-7506-0167-2 5369:978-1-4557-5942-2 5062:978-0-8153-4455-1 5008:Annals of Surgery 4964:10.1159/000077038 4951:Digestive Surgery 4768:(5 Pt 1): 435–9. 4626:10.1172/JCI113382 4575:978-2-294-72233-2 4009:978-1-4557-4377-3 3749:978-0-387-30348-2 3717:978-0-321-86158-0 3706:Marieb E (2014). 3635:978-1-4160-6257-8 3518:Bainbridge reflex 3337:(increased blood 3246:Contraindications 3080: 3079: 2953:VP/OT Superfamily 2834:New World monkeys 2796:-Gln-Asn-Cys-Pro- 2764:-Gln-Asn-Cys-Pro- 2686:-Gln-Asn-Cys-Pro- 2651:The structure of 2564:in this position. 2541: 2540: 2524:endothelial cells 2491:Adenylate cyclase 2106:connecting tubule 2098:urea transporters 1969:sexual motivation 1863: 1862: 1859: 1858: 1832: 1831: 1797: 1796: 1776: 1775: 1750: 1749: 1729: 1728: 1703: 1702: 1684: 1683: 1658: 1657: 1639: 1638: 1613: 1612: 1594: 1593: 1542: 1541: 1497:maternal behavior 1432:grooming behavior 1392:apoptotic process 1306:secretory granule 1212: 1211: 1208: 1207: 1177: 1176: 1164: 1163: 1102: 1101: 1000: 999: 899: 898: 712: 711: 663:1.6±0.1 g/cm 648:Interactive image 544:CompTox Dashboard 16:(Redirected from 9252: 9220:Renal physiology 8722: 8721: 8697:o-Phenanthroline 8684: 8461: 8454: 8447: 8438: 8437: 8409:Nitrous oxide (N 8380: 8379: 8349:Gasotransmitters 8346: 8345: 8326: 8325: 8316: 8270: 8269: 8263: 8262: 8230: 8229: 8165:Anandamide (AEA) 8133:Endocannabinoids 8130: 8129: 8097: 8096: 7984:Serotonin (5-HT) 7949: 7948: 7768:Glutamate system 7765: 7764: 7756: 7755: 7735: 7728: 7721: 7712: 7711: 7466: 7465: 7273: 7272: 7234: 7227: 7220: 7211: 7210: 7162:Extraction ratio 7065:Winters' formula 6941: 6940: 6904:Renal blood flow 6830:Pharmacokinetics 6815: 6814: 6790: 6783: 6776: 6767: 6766: 6524: 6523: 6519:Digestive system 6475: 6474: 6290: 6289: 6229:Thyroid hormones 6005: 6004: 5994: 5993: 5972: 5965: 5958: 5949: 5948: 5931: 5916: 5901: 5886: 5866: 5859: 5852: 5843: 5842: 5837: 5835: 5834: 5825:. Archived from 5795: 5794: 5758: 5752: 5751: 5741: 5731: 5707: 5701: 5700: 5664: 5658: 5657: 5639: 5619: 5610: 5609: 5598:10.1148/98.3.497 5581: 5575: 5574: 5572: 5571: 5565: 5557: 5542: 5541: 5505: 5499: 5498: 5470: 5464: 5463: 5453: 5421: 5415: 5414: 5391:(2nd ed.). 5380: 5374: 5373: 5362:. p. 1833. 5358:(5th ed.). 5349: 5343: 5342: 5332: 5300: 5294: 5293: 5283: 5259: 5253: 5252: 5212: 5206: 5205: 5195: 5163: 5157: 5156: 5138: 5114: 5108: 5107: 5097: 5073: 5067: 5066: 5048: 5042: 5041: 5031: 4999: 4993: 4992: 4966: 4942: 4936: 4935: 4915: 4909: 4908: 4872: 4866: 4865: 4829: 4823: 4822: 4794: 4788: 4787: 4777: 4753: 4747: 4746: 4725: 4719: 4718: 4689: 4683: 4682: 4654: 4648: 4647: 4637: 4605: 4599: 4598: 4586: 4580: 4579: 4561: 4555: 4554: 4526: 4517: 4516: 4496: 4490: 4489: 4471: 4447: 4441: 4440: 4422: 4398: 4392: 4391: 4355: 4349: 4348: 4338: 4306: 4300: 4299: 4281: 4257: 4251: 4250: 4240: 4208: 4202: 4201: 4191: 4159: 4153: 4152: 4142: 4118: 4112: 4111: 4101: 4077: 4071: 4070: 4060: 4028: 4022: 4021: 3995: 3989: 3988: 3976: 3970: 3969: 3933: 3927: 3926: 3906: 3900: 3899: 3889: 3857: 3851: 3850: 3840: 3808: 3802: 3801: 3765: 3754: 3753: 3737: 3728: 3722: 3721: 3703: 3697: 3696: 3678: 3646: 3640: 3639: 3619: 3613: 3612: 3601: 3595: 3594: 3583: 3577: 3567: 3556: 3546: 3454:bipolar disorder 3397:fluoroquinolones 3341:concentration), 3240:hypersensitivity 3154:Pharmacokinetics 3125:vasoconstrictors 3033:Arg-Connopressin 3002:Lys-Connopressin 2669: 2501:collecting ducts 2420:Vasoconstriction 2367: 2366: 2173:circadian rhythm 2019:vasoconstriction 1995:Renal physiology 1845: 1844: 1816: 1809: 1792: 1780: 1779: 1771: 1759: 1758: 1755:RefSeq (protein) 1745: 1733: 1732: 1724: 1712: 1711: 1688: 1687: 1669: 1668: 1643: 1642: 1624: 1623: 1598: 1597: 1579: 1578: 1548: 1547: 1332:vasoconstriction 1240:hormone activity 1218: 1217: 1204: 1195: 1188: 1187: 1173: 1113: 1111:Top expressed in 1106: 1105: 1051: 1049:Top expressed in 1044: 1043: 1023: 1022: 1006: 1005: 996: 983: 972: 957: 950: 944: 933: 921: 905: 904: 895: 882: 871: 856: 849: 843: 832: 818: 802: 801: 796: 747: 740: 726: 714: 713: 650: 630: 628: 611: 605: 599: 593: 587: 567: 566: 552: 550: 535: 515: 495: 475: 455: 435: 415: 395: 385: 384: 370: 314: 155: 125: 124: 121: 120: 117: 114: 111: 108: 105: 102: 99: 96: 93: 90: 87: 67: 58: 51: 49: 45: 21: 9260: 9259: 9255: 9254: 9253: 9251: 9250: 9249: 9245:Stress hormones 9190: 9189: 9188: 9183: 9151: 9082: 8977: 8968: 8873: 8864: 8729: 8711: 8517:Lipo-oxytocin-1 8477: 8465: 8435: 8426: 8421: 8412: 8398: 8374: 8364: 8340: 8297: 8243: 8219: 8110: 8082: 8066: 7988: 7944:Biogenic amines 7934: 7911: 7860: 7834: 7760: 7744: 7739: 7709: 7700: 7656:Neuropeptide VF 7651:Neuropeptide SF 7646:Neuropeptide FF 7641:Neuropeptide AF 7574: 7551: 7520: 7461: 7451: 7398: 7375: 7347: 7324: 7293: 7268:Opioid peptides 7262: 7247: 7238: 7208: 7203: 7167: 7088: 7027: 6985: 6937:Other functions 6928: 6914:Ultrafiltration 6890: 6844: 6840:Urine flow rate 6803: 6794: 6764: 6755: 6725: 6692: 6674: 6642: 6611: 6583: 6545: 6513: 6462: 6434: 6392: 6359: 6316: 6279: 6261: 6245: 6237: 6215: 6199:Adrenal medulla 6192:Androstenedione 6144: 6074: 6051: 5999: 5988: 5981: 5976: 5946: 5941: 5938: 5932: 5923: 5917: 5908: 5902: 5893: 5887: 5873: 5870: 5840: 5832: 5830: 5823: 5804: 5802:Further reading 5799: 5798: 5759: 5755: 5708: 5704: 5665: 5661: 5637:10.1.1.499.7585 5620: 5613: 5582: 5578: 5569: 5567: 5563: 5559: 5558: 5545: 5506: 5502: 5471: 5467: 5422: 5418: 5411: 5381: 5377: 5370: 5350: 5346: 5321:10.1172/JCI9516 5301: 5297: 5260: 5256: 5213: 5209: 5164: 5160: 5115: 5111: 5074: 5070: 5063: 5049: 5045: 5000: 4996: 4943: 4939: 4916: 4912: 4873: 4869: 4830: 4826: 4795: 4791: 4754: 4750: 4737:(9): CR445-52. 4726: 4722: 4690: 4686: 4655: 4651: 4606: 4602: 4587: 4583: 4576: 4562: 4558: 4527: 4520: 4497: 4493: 4448: 4444: 4399: 4395: 4372:10.1038/nn.2987 4356: 4352: 4307: 4303: 4258: 4254: 4223:(6): F1143–59. 4209: 4205: 4160: 4156: 4119: 4115: 4078: 4074: 4029: 4025: 4010: 3996: 3992: 3977: 3973: 3934: 3930: 3907: 3903: 3858: 3854: 3809: 3805: 3776:(10): 1359–63. 3766: 3757: 3750: 3735: 3729: 3725: 3718: 3704: 3700: 3647: 3643: 3636: 3620: 3616: 3603: 3602: 3598: 3585: 3584: 3580: 3568: 3559: 3547: 3538: 3533: 3466: 3438: 3429: 3417: 3361: 3355: 3327: 3294:fludrocortisone 3282:chloropropamide 3268: 3248: 3196: 3156: 3091: 3085: 3063: 3045: 3029: 2998: 2980: 2962: 2936: 2918: 2900: 2882: 2847: 2823: 2803: 2771: 2744: 2713: 2693: 2627: 2546: 2465:Pituitary gland 2451:AVPR1B or AVPR3 2362: 2354:noxious stimuli 2350:surgical stress 2346: 2330:median eminence 2275: 2240:gene products. 2203: 2197: 2195:Gene regulation 2192: 2165: 2137:collecting duct 2078:apical membrane 2061: 2002: 1997: 1991: 1965:social behavior 1930:hyperosmolality 1854:View/Edit Mouse 1849:View/Edit Human 1812: 1805: 1802:Location (UCSC) 1788: 1767: 1741: 1720: 1633:ENSG00000101200 1526: 1502:penile erection 1482:social behavior 1347:water transport 1315: 1274: 1200: 1169: 1160: 1155: 1151: 1147: 1143: 1139: 1137:median eminence 1135: 1131: 1129:arcuate nucleus 1127: 1123: 1109: 1098: 1093: 1089: 1085: 1081: 1077: 1073: 1069: 1065: 1061: 1047: 991: 978: 970: 960: 959: 958: 951: 931: 908:Gene location ( 890: 877: 869: 859: 858: 857: 850: 828: 805:Gene location ( 794:AVP - orthologs 756: 743: 736: 708: 705: 700: 695: 694: 683: 680: 675: 674: 653: 626: 624: 614: 608: 602: 596: 590: 570: 546: 538: 518: 498: 478: 458: 438: 418: 398: 381: 373: 353: 350: 345: 344: 312: 284:Protein binding 276:Pharmacokinetic 220: 213: 206: 159: 84: 80: 44: 37: 28: 23: 22: 15: 12: 11: 5: 9258: 9248: 9247: 9242: 9237: 9232: 9227: 9222: 9217: 9212: 9207: 9202: 9185: 9184: 9182: 9181: 9163: 9161: 9157: 9156: 9153: 9152: 9150: 9149: 9139: 9137:Demeclocycline 9130: 9129: 9124: 9119: 9114: 9109: 9104: 9099: 9090: 9088: 9084: 9083: 9081: 9080: 9075: 9070: 9065: 9060: 9055: 9050: 9045: 9040: 9031: 9030: 9025: 9020: 9015: 9010: 9005: 9000: 8995: 8990: 8981: 8979: 8975: 8970: 8969: 8967: 8966: 8957: 8956: 8951: 8946: 8941: 8936: 8931: 8926: 8917: 8916: 8911: 8906: 8901: 8896: 8891: 8886: 8877: 8875: 8871: 8866: 8865: 8863: 8862: 8857: 8852: 8847: 8842: 8837: 8832: 8827: 8822: 8817: 8812: 8807: 8802: 8797: 8792: 8787: 8782: 8773: 8772: 8767: 8762: 8757: 8752: 8747: 8742: 8733: 8731: 8727: 8719: 8713: 8712: 8710: 8709: 8704: 8702:Phosphoramidon 8699: 8694: 8689: 8681: 8676: 8671: 8662: 8661: 8656: 8651: 8646: 8641: 8636: 8631: 8626: 8621: 8616: 8611: 8606: 8594: 8582: 8581: 8576: 8571: 8566: 8561: 8549: 8544: 8539: 8534: 8529: 8524: 8519: 8514: 8509: 8504: 8499: 8487: 8485: 8479: 8478: 8464: 8463: 8456: 8449: 8441: 8432: 8431: 8428: 8427: 8425: 8424: 8419: 8415: 8410: 8406: 8401: 8396: 8392: 8386: 8384: 8376: 8375: 8373: 8372: 8367: 8362: 8358: 8352: 8350: 8342: 8341: 8339: 8338: 8332: 8330: 8323: 8319: 8318: 8314: 8307: 8306: 8303: 8302: 8299: 8298: 8296: 8295: 8290: 8285: 8279: 8277: 8267: 8260: 8253: 8252: 8249: 8248: 8245: 8244: 8242: 8241: 8233: 8227: 8221: 8220: 8218: 8217: 8212: 8207: 8202: 8197: 8192: 8187: 8182: 8177: 8172: 8167: 8162: 8157: 8152: 8147: 8142: 8136: 8134: 8127: 8120: 8119: 8116: 8115: 8112: 8111: 8109: 8108: 8100: 8094: 8088: 8087: 8084: 8083: 8081: 8080: 8074: 8072: 8068: 8067: 8065: 8064: 8056: 8048: 8043: 8038: 8036:Phenethylamine 8033: 8028: 8020: 8012: 8007: 8002: 7996: 7994: 7990: 7989: 7987: 7986: 7981: 7976: 7971: 7966: 7961: 7955: 7953: 7946: 7940: 7939: 7936: 7935: 7933: 7932: 7927: 7921: 7919: 7913: 7912: 7910: 7909: 7904: 7899: 7894: 7889: 7884: 7879: 7874: 7868: 7866: 7865:Glycine system 7862: 7861: 7859: 7858: 7853: 7848: 7842: 7840: 7836: 7835: 7833: 7832: 7827: 7822: 7817: 7812: 7810:Kynurenic acid 7807: 7802: 7797: 7792: 7787: 7782: 7777: 7771: 7769: 7762: 7753: 7746: 7745: 7738: 7737: 7730: 7723: 7715: 7706: 7705: 7702: 7701: 7699: 7698: 7693: 7688: 7683: 7678: 7673: 7668: 7666:Neuropeptide Y 7663: 7661:Neuropeptide S 7658: 7653: 7648: 7643: 7638: 7633: 7628: 7623: 7618: 7613: 7608: 7603: 7598: 7593: 7588: 7582: 7580: 7576: 7575: 7573: 7572: 7567: 7561: 7559: 7553: 7552: 7550: 7549: 7544: 7539: 7534: 7528: 7526: 7522: 7521: 7519: 7518: 7517: 7516: 7511: 7503: 7502: 7501: 7496: 7491: 7480: 7474: 7472: 7463: 7457: 7456: 7453: 7452: 7450: 7449: 7444: 7439: 7434: 7429: 7428: 7427: 7417: 7412: 7406: 7404: 7400: 7399: 7397: 7396: 7394:Leu-enkephalin 7391: 7389:Met-enkephalin 7385: 7383: 7377: 7376: 7374: 7373: 7368: 7363: 7357: 7355: 7349: 7348: 7346: 7345: 7340: 7334: 7332: 7326: 7325: 7323: 7322: 7320:β-Neoendorphin 7317: 7315:α-Neoendorphin 7312: 7307: 7302: 7297: 7296: 7295: 7291: 7281: 7279: 7270: 7264: 7263: 7255: 7253: 7249: 7248: 7237: 7236: 7229: 7222: 7214: 7205: 7204: 7202: 7201: 7196: 7191: 7186: 7181: 7175: 7173: 7169: 7168: 7166: 7165: 7159: 7150: 7149: 7148: 7138: 7133: 7128: 7123: 7118: 7113: 7108: 7102: 7100: 7094: 7093: 7090: 7089: 7087: 7086: 7085: 7080: 7075: 7067: 7062: 7052: 7047: 7042: 7037: 7035: 7029: 7028: 7026: 7025: 7019: 7014: 7008: 6995: 6993: 6987: 6986: 6984: 6983: 6981:Prostaglandins 6978: 6973: 6971:Erythropoietin 6968: 6963: 6958: 6953: 6947: 6945: 6938: 6934: 6933: 6930: 6929: 6927: 6926: 6921: 6916: 6911: 6906: 6900: 6898: 6892: 6891: 6889: 6888: 6883: 6878: 6873: 6868: 6863: 6858: 6852: 6850: 6846: 6845: 6843: 6842: 6837: 6832: 6827: 6821: 6819: 6812: 6805: 6804: 6793: 6792: 6785: 6778: 6770: 6761: 6760: 6757: 6756: 6754: 6753: 6752: 6751: 6746: 6735: 6733: 6727: 6726: 6724: 6723: 6718: 6713: 6708: 6702: 6700: 6694: 6693: 6691: 6690: 6684: 6682: 6676: 6675: 6673: 6672: 6667: 6662: 6656: 6654: 6652:Adipose tissue 6648: 6647: 6644: 6643: 6641: 6640: 6639: 6638: 6633: 6622: 6620: 6613: 6612: 6610: 6609: 6604: 6599: 6597:Enteroglucagon 6593: 6591: 6585: 6584: 6582: 6581: 6576: 6571: 6566: 6561: 6555: 6553: 6547: 6546: 6544: 6543: 6538: 6532: 6530: 6521: 6515: 6514: 6512: 6511: 6506: 6501: 6500: 6499: 6497:Beta thymosins 6494: 6483: 6481: 6472: 6468: 6467: 6464: 6463: 6461: 6460: 6455: 6450: 6444: 6442: 6436: 6435: 6433: 6432: 6427: 6422: 6417: 6412: 6406: 6404: 6398: 6397: 6394: 6393: 6391: 6390: 6385: 6380: 6375: 6369: 6367: 6361: 6360: 6358: 6357: 6352: 6347: 6342: 6337: 6332: 6326: 6324: 6318: 6317: 6315: 6314: 6309: 6304: 6298: 6296: 6287: 6281: 6280: 6278: 6277: 6271: 6269: 6263: 6262: 6260: 6259: 6254: 6249: 6248: 6247: 6243: 6239: 6235: 6225: 6223: 6217: 6216: 6214: 6213: 6212: 6211: 6209:Norepinephrine 6206: 6196: 6195: 6194: 6189: 6184: 6179: 6174: 6169: 6162:Adrenal cortex 6158: 6156: 6150: 6149: 6146: 6145: 6143: 6142: 6137: 6136: 6135: 6130: 6125: 6120: 6115: 6105: 6100: 6095: 6090: 6084: 6082: 6076: 6075: 6073: 6072: 6067: 6061: 6059: 6053: 6052: 6050: 6049: 6044: 6039: 6034: 6029: 6024: 6019: 6013: 6011: 6002: 5991: 5983: 5982: 5975: 5974: 5967: 5960: 5952: 5943: 5942: 5940: 5939: 5933: 5926: 5924: 5918: 5911: 5909: 5903: 5896: 5894: 5888: 5881: 5878: 5875: 5874: 5869: 5868: 5861: 5854: 5846: 5839: 5838: 5821: 5805: 5803: 5800: 5797: 5796: 5769:(4): 341–347. 5753: 5702: 5659: 5611: 5592:(3): 497–505. 5576: 5543: 5500: 5481:(10): 2480–6. 5465: 5416: 5409: 5375: 5368: 5344: 5295: 5254: 5207: 5158: 5109: 5068: 5061: 5043: 5014:(2): 219–226. 4994: 4937: 4910: 4883:(12): 979–82. 4867: 4824: 4805:(5): 597–600. 4789: 4748: 4720: 4684: 4649: 4600: 4581: 4574: 4556: 4518: 4491: 4442: 4393: 4366:(12): 1496–7. 4350: 4315:Auton Neurosci 4301: 4252: 4203: 4154: 4113: 4072: 4023: 4008: 3990: 3971: 3928: 3901: 3852: 3803: 3755: 3748: 3723: 3716: 3698: 3661:(2): 295–306. 3641: 3634: 3614: 3596: 3578: 3557: 3535: 3534: 3532: 3529: 3528: 3527: 3521: 3515: 3509: 3503: 3498: 3493: 3488: 3483: 3478: 3473: 3465: 3462: 3437: 3434: 3428: 3427:Animal studies 3425: 3416: 3413: 3357:Main article: 3354: 3351: 3326: 3323: 3322: 3321: 3315: 3312:norepinephrine 3304:demeclocycline 3297: 3275: 3267: 3264: 3256:kidney failure 3247: 3244: 3195: 3192: 3155: 3152: 3148:norepinephrine 3140:catecholamines 3087:Main article: 3084: 3081: 3078: 3077: 3073: 3072: 3069: 3064: 3061: 3057: 3056: 3051: 3046: 3043: 3039: 3038: 3035: 3030: 3027: 3023: 3022: 3004: 2999: 2996: 2992: 2991: 2986: 2981: 2978: 2974: 2973: 2968: 2963: 2960: 2956: 2955: 2946: 2945: 2940: 2939:Various tocins 2937: 2934: 2930: 2929: 2924: 2919: 2916: 2912: 2911: 2906: 2901: 2898: 2894: 2893: 2888: 2883: 2880: 2876: 2875: 2853: 2848: 2845: 2841: 2840: 2830: 2824: 2821: 2817: 2816: 2812:Most mammals, 2810: 2804: 2801: 2789: 2788: 2782: 2781: 2778: 2772: 2769: 2757: 2756: 2750: 2745: 2742: 2738: 2737: 2720: 2714: 2711: 2707: 2706: 2700: 2694: 2691: 2679: 2678: 2630:disulfide bond 2625: 2545: 2542: 2539: 2538: 2532: 2526: 2504: 2497: 2488: 2482: 2481: 2479: 2477: 2471: 2462: 2453: 2447: 2446: 2444: 2439: 2417: 2404: 2395: 2389: 2388: 2385: 2382: 2379: 2376: 2371: 2361: 2358: 2345: 2342: 2274: 2271: 2270: 2269: 2263: 2257: 2251: 2196: 2193: 2191: 2188: 2187: 2186: 2183: 2180: 2164: 2161: 2141: 2140: 2117: 2090: 2060: 2057: 2001: 1998: 1990: 1987: 1980:cardiomyocytes 1954:blood pressure 1938:kidney tubules 1869:, also called 1861: 1860: 1857: 1856: 1851: 1841: 1840: 1834: 1833: 1830: 1829: 1827: 1825: 1818: 1817: 1810: 1803: 1799: 1798: 1795: 1794: 1784: 1783: 1777: 1774: 1773: 1763: 1762: 1756: 1752: 1751: 1748: 1747: 1737: 1736: 1730: 1727: 1726: 1716: 1715: 1709: 1705: 1704: 1701: 1700: 1692: 1691: 1685: 1682: 1681: 1673: 1672: 1666: 1660: 1659: 1656: 1655: 1647: 1646: 1640: 1637: 1636: 1628: 1627: 1621: 1615: 1614: 1611: 1610: 1602: 1601: 1595: 1592: 1591: 1583: 1582: 1576: 1570: 1569: 1564: 1559: 1555: 1554: 1544: 1543: 1540: 1539: 1528: 1527: 1525: 1524: 1519: 1514: 1509: 1504: 1499: 1494: 1489: 1484: 1479: 1474: 1469: 1464: 1459: 1454: 1449: 1444: 1439: 1434: 1429: 1424: 1419: 1414: 1409: 1404: 1399: 1394: 1389: 1384: 1379: 1374: 1369: 1364: 1359: 1354: 1349: 1344: 1339: 1334: 1329: 1323: 1321: 1317: 1316: 1314: 1313: 1308: 1303: 1298: 1293: 1288: 1282: 1280: 1276: 1275: 1273: 1272: 1267: 1262: 1257: 1252: 1247: 1242: 1237: 1231: 1229: 1225: 1224: 1214: 1213: 1210: 1209: 1206: 1205: 1197: 1196: 1185: 1179: 1178: 1175: 1174: 1166: 1165: 1162: 1161: 1159: 1158: 1154: 1150: 1146: 1142: 1138: 1134: 1130: 1126: 1122: 1118: 1115: 1114: 1103: 1100: 1099: 1097: 1096: 1092: 1088: 1084: 1080: 1076: 1072: 1068: 1067:gastric mucosa 1064: 1060: 1056: 1053: 1052: 1040: 1039: 1031: 1020: 1014: 1013: 1010:RNA expression 1002: 1001: 998: 997: 989: 985: 984: 976: 973: 968: 962: 961: 952: 945: 939: 935: 934: 929: 923: 922: 914: 913: 901: 900: 897: 896: 888: 884: 883: 875: 872: 867: 861: 860: 851: 844: 838: 834: 833: 826: 820: 819: 811: 810: 798: 797: 754: 750: 749: 741: 733: 732: 728: 727: 719: 718: 710: 709: 707: 706: 703: 701: 698: 690: 689: 688: 685: 684: 682: 681: 678: 670: 669: 668: 665: 664: 661: 655: 654: 652: 651: 643: 641: 633: 632: 622: 616: 615: 612: 606: 600: 594: 588: 583: 577: 576: 572: 571: 569: 568: 555: 553: 540: 539: 537: 536: 528: 526: 520: 519: 517: 516: 508: 506: 500: 499: 497: 496: 488: 486: 480: 479: 477: 476: 468: 466: 460: 459: 457: 456: 448: 446: 440: 439: 437: 436: 428: 426: 420: 419: 417: 416: 408: 406: 400: 399: 397: 396: 388: 386: 375: 374: 372: 371: 363: 361: 355: 354: 352: 351: 348: 340: 339: 338: 335: 334: 330: 329: 326: 320: 319: 316: 307: 306: 296: 290: 289: 286: 280: 279: 272: 271: 261: 255: 254: 249: 243: 242: 233: 227: 226: 218: 211: 204: 200: 194: 193: 190: 189:Target tissues 186: 185: 176: 169: 168: 161: 160: 158: 157: 144: 142: 136: 135: 132: 128: 127: 78: 74: 73: 69: 68: 60: 59: 26: 9: 6: 4: 3: 2: 9257: 9246: 9243: 9241: 9238: 9236: 9235:Antidiuretics 9233: 9231: 9228: 9226: 9223: 9221: 9218: 9216: 9213: 9211: 9208: 9206: 9205:Neuropeptides 9203: 9201: 9198: 9197: 9195: 9179: 9175: 9171: 9168: 9165: 9164: 9162: 9158: 9147: 9143: 9140: 9138: 9135: 9132: 9131: 9128: 9125: 9123: 9120: 9118: 9115: 9113: 9110: 9108: 9105: 9103: 9100: 9098: 9095: 9092: 9091: 9089: 9085: 9079: 9076: 9074: 9071: 9069: 9066: 9064: 9061: 9059: 9056: 9054: 9051: 9049: 9046: 9044: 9041: 9039: 9036: 9033: 9032: 9029: 9026: 9024: 9021: 9019: 9016: 9014: 9011: 9009: 9006: 9004: 9001: 8999: 8996: 8994: 8991: 8989: 8986: 8983: 8982: 8980: 8978: 8971: 8965: 8962: 8959: 8958: 8955: 8952: 8950: 8947: 8945: 8942: 8940: 8937: 8935: 8932: 8930: 8927: 8925: 8922: 8919: 8918: 8915: 8912: 8910: 8907: 8905: 8902: 8900: 8897: 8895: 8892: 8890: 8887: 8885: 8882: 8879: 8878: 8876: 8874: 8867: 8861: 8858: 8856: 8853: 8851: 8848: 8846: 8843: 8841: 8838: 8836: 8833: 8831: 8828: 8826: 8823: 8821: 8818: 8816: 8813: 8811: 8808: 8806: 8803: 8801: 8798: 8796: 8793: 8791: 8788: 8786: 8783: 8781: 8778: 8775: 8774: 8771: 8768: 8766: 8763: 8761: 8758: 8756: 8753: 8751: 8748: 8746: 8743: 8741: 8738: 8735: 8734: 8732: 8730: 8723: 8720: 8718: 8714: 8708: 8705: 8703: 8700: 8698: 8695: 8693: 8690: 8688: 8682: 8680: 8677: 8675: 8672: 8670: 8667: 8664: 8663: 8660: 8657: 8655: 8652: 8650: 8647: 8645: 8642: 8640: 8637: 8635: 8632: 8630: 8627: 8625: 8622: 8620: 8617: 8615: 8612: 8610: 8607: 8605: 8602: 8598: 8597:Tocinoic acid 8595: 8593: 8590: 8587: 8584: 8583: 8580: 8577: 8575: 8572: 8570: 8567: 8565: 8562: 8560: 8557: 8553: 8550: 8548: 8545: 8543: 8540: 8538: 8535: 8533: 8530: 8528: 8525: 8523: 8520: 8518: 8515: 8513: 8510: 8508: 8505: 8503: 8500: 8498: 8495: 8492: 8489: 8488: 8486: 8484: 8480: 8476: 8473: 8469: 8462: 8457: 8455: 8450: 8448: 8443: 8442: 8439: 8423: 8416: 8414: 8407: 8405: 8402: 8400: 8393: 8391: 8388: 8387: 8385: 8381: 8371: 8368: 8366: 8359: 8357: 8354: 8353: 8351: 8347: 8337: 8336:Acetylcholine 8334: 8333: 8331: 8327: 8324: 8322:Miscellaneous 8320: 8315: 8312: 8308: 8294: 8291: 8289: 8286: 8284: 8281: 8280: 8278: 8275: 8271: 8268: 8264: 8261: 8258: 8254: 8239: 8235: 8234: 8231: 8228: 8226: 8225:Neurosteroids 8222: 8216: 8213: 8211: 8208: 8206: 8203: 8201: 8198: 8196: 8193: 8191: 8188: 8186: 8183: 8181: 8178: 8176: 8173: 8171: 8168: 8166: 8163: 8161: 8158: 8156: 8153: 8151: 8148: 8146: 8143: 8141: 8138: 8137: 8135: 8131: 8128: 8125: 8121: 8106: 8102: 8101: 8098: 8095: 8093: 8092:Neuropeptides 8089: 8079: 8076: 8075: 8073: 8069: 8063: 8061: 8057: 8055: 8053: 8049: 8047: 8044: 8042: 8039: 8037: 8034: 8032: 8029: 8027: 8025: 8021: 8019: 8017: 8013: 8011: 8008: 8006: 8003: 8001: 7998: 7997: 7995: 7991: 7985: 7982: 7980: 7977: 7975: 7972: 7970: 7967: 7965: 7962: 7960: 7957: 7956: 7954: 7950: 7947: 7945: 7941: 7931: 7928: 7926: 7923: 7922: 7920: 7918: 7914: 7908: 7905: 7903: 7900: 7898: 7895: 7893: 7890: 7888: 7885: 7883: 7880: 7878: 7875: 7873: 7870: 7869: 7867: 7863: 7857: 7854: 7852: 7849: 7847: 7844: 7843: 7841: 7837: 7831: 7828: 7826: 7823: 7821: 7818: 7816: 7813: 7811: 7808: 7806: 7803: 7801: 7798: 7796: 7793: 7791: 7788: 7786: 7783: 7781: 7778: 7776: 7773: 7772: 7770: 7766: 7763: 7757: 7754: 7751: 7747: 7743: 7736: 7731: 7729: 7724: 7722: 7717: 7716: 7713: 7697: 7694: 7692: 7689: 7687: 7684: 7682: 7679: 7677: 7674: 7672: 7669: 7667: 7664: 7662: 7659: 7657: 7654: 7652: 7649: 7647: 7644: 7642: 7639: 7637: 7634: 7632: 7629: 7627: 7624: 7622: 7619: 7617: 7614: 7612: 7609: 7607: 7604: 7602: 7599: 7597: 7594: 7592: 7589: 7587: 7584: 7583: 7581: 7577: 7571: 7568: 7566: 7563: 7562: 7560: 7558: 7554: 7548: 7545: 7543: 7540: 7538: 7535: 7533: 7530: 7529: 7527: 7523: 7515: 7512: 7510: 7507: 7506: 7504: 7500: 7497: 7495: 7492: 7490: 7487: 7486: 7484: 7481: 7479: 7476: 7475: 7473: 7471: 7467: 7464: 7462:neuropeptides 7458: 7448: 7445: 7443: 7440: 7438: 7435: 7433: 7430: 7426: 7423: 7422: 7421: 7418: 7416: 7413: 7411: 7408: 7407: 7405: 7401: 7395: 7392: 7390: 7387: 7386: 7384: 7382: 7378: 7372: 7369: 7367: 7364: 7362: 7359: 7358: 7356: 7354: 7350: 7344: 7343:Endomorphin-2 7341: 7339: 7338:Endomorphin-1 7336: 7335: 7333: 7331: 7327: 7321: 7318: 7316: 7313: 7311: 7308: 7306: 7305:Big dynorphin 7303: 7301: 7298: 7294: 7288: 7287: 7286: 7283: 7282: 7280: 7278: 7274: 7271: 7269: 7265: 7261: 7260: 7254: 7250: 7246: 7245:neuropeptides 7242: 7235: 7230: 7228: 7223: 7221: 7216: 7215: 7212: 7200: 7197: 7195: 7192: 7190: 7187: 7185: 7182: 7180: 7177: 7176: 7174: 7170: 7163: 7160: 7158: 7154: 7153:PAH clearance 7151: 7147: 7144: 7143: 7142: 7139: 7137: 7134: 7132: 7129: 7127: 7124: 7122: 7119: 7117: 7114: 7112: 7109: 7107: 7104: 7103: 7101: 7099: 7095: 7084: 7081: 7079: 7076: 7074: 7071: 7070: 7068: 7066: 7063: 7060: 7056: 7053: 7051: 7048: 7046: 7043: 7041: 7038: 7036: 7034: 7030: 7023: 7020: 7018: 7015: 7013: 7009: 7007: 7004: 7003: 7002: 6998: 6994: 6992: 6991:Fluid balance 6988: 6982: 6979: 6977: 6974: 6972: 6969: 6967: 6964: 6962: 6959: 6957: 6954: 6952: 6949: 6948: 6946: 6942: 6939: 6935: 6925: 6922: 6920: 6917: 6915: 6912: 6910: 6907: 6905: 6902: 6901: 6899: 6897: 6893: 6887: 6884: 6882: 6881:Oligopeptides 6879: 6877: 6874: 6872: 6869: 6867: 6864: 6862: 6859: 6857: 6854: 6853: 6851: 6847: 6841: 6838: 6836: 6833: 6831: 6828: 6826: 6823: 6822: 6820: 6816: 6813: 6811: 6806: 6802: 6798: 6791: 6786: 6784: 6779: 6777: 6772: 6771: 6768: 6750: 6747: 6745: 6742: 6741: 6740: 6737: 6736: 6734: 6732: 6728: 6722: 6721:Prostaglandin 6719: 6717: 6714: 6712: 6709: 6707: 6704: 6703: 6701: 6699: 6695: 6689: 6686: 6685: 6683: 6681: 6677: 6671: 6668: 6666: 6663: 6661: 6658: 6657: 6655: 6653: 6649: 6637: 6634: 6632: 6629: 6628: 6627: 6624: 6623: 6621: 6618: 6614: 6608: 6605: 6603: 6600: 6598: 6595: 6594: 6592: 6590: 6586: 6580: 6577: 6575: 6572: 6570: 6567: 6565: 6562: 6560: 6557: 6556: 6554: 6552: 6548: 6542: 6539: 6537: 6534: 6533: 6531: 6529: 6525: 6522: 6520: 6516: 6510: 6507: 6505: 6502: 6498: 6495: 6493: 6490: 6489: 6488: 6485: 6484: 6482: 6480: 6476: 6473: 6469: 6459: 6456: 6454: 6451: 6449: 6446: 6445: 6443: 6441: 6437: 6431: 6428: 6426: 6423: 6421: 6418: 6416: 6413: 6411: 6408: 6407: 6405: 6403: 6399: 6389: 6386: 6384: 6381: 6379: 6376: 6374: 6371: 6370: 6368: 6366: 6362: 6356: 6353: 6351: 6348: 6346: 6343: 6341: 6338: 6336: 6333: 6331: 6328: 6327: 6325: 6323: 6319: 6313: 6310: 6308: 6305: 6303: 6300: 6299: 6297: 6295: 6291: 6288: 6286: 6282: 6276: 6273: 6272: 6270: 6268: 6264: 6258: 6255: 6253: 6250: 6246: 6240: 6238: 6232: 6231: 6230: 6227: 6226: 6224: 6222: 6218: 6210: 6207: 6205: 6202: 6201: 6200: 6197: 6193: 6190: 6188: 6185: 6183: 6180: 6178: 6175: 6173: 6170: 6168: 6165: 6164: 6163: 6160: 6159: 6157: 6155: 6151: 6141: 6138: 6134: 6131: 6129: 6126: 6124: 6121: 6119: 6116: 6114: 6111: 6110: 6109: 6106: 6104: 6101: 6099: 6096: 6094: 6091: 6089: 6086: 6085: 6083: 6081: 6077: 6071: 6068: 6066: 6063: 6062: 6060: 6058: 6054: 6048: 6045: 6043: 6040: 6038: 6035: 6033: 6030: 6028: 6025: 6023: 6020: 6018: 6015: 6014: 6012: 6010: 6006: 6003: 6001: 5998:Hypothalamic– 5995: 5992: 5990: 5984: 5980: 5973: 5968: 5966: 5961: 5959: 5954: 5953: 5950: 5936: 5930: 5925: 5921: 5915: 5910: 5906: 5900: 5895: 5891: 5885: 5880: 5879: 5876: 5867: 5862: 5860: 5855: 5853: 5848: 5847: 5844: 5829:on 2016-03-03 5828: 5824: 5818: 5814: 5813: 5807: 5806: 5792: 5788: 5784: 5780: 5776: 5772: 5768: 5764: 5757: 5749: 5745: 5740: 5735: 5730: 5725: 5721: 5717: 5713: 5706: 5698: 5694: 5690: 5686: 5682: 5678: 5674: 5670: 5663: 5655: 5651: 5647: 5643: 5638: 5633: 5629: 5625: 5618: 5616: 5607: 5603: 5599: 5595: 5591: 5587: 5580: 5562: 5561:"Vasopressin" 5556: 5554: 5552: 5550: 5548: 5539: 5535: 5531: 5527: 5523: 5519: 5516:(3): 237–89. 5515: 5511: 5504: 5496: 5492: 5488: 5484: 5480: 5476: 5469: 5461: 5457: 5452: 5447: 5443: 5439: 5436:(2): 225–32. 5435: 5431: 5427: 5420: 5412: 5406: 5402: 5398: 5394: 5390: 5386: 5379: 5371: 5365: 5361: 5357: 5356: 5348: 5340: 5336: 5331: 5326: 5322: 5318: 5315:(1): 107–16. 5314: 5310: 5306: 5299: 5291: 5287: 5282: 5277: 5274:(7): 2760–6. 5273: 5269: 5265: 5258: 5250: 5246: 5242: 5238: 5234: 5230: 5227:(5): 638–45. 5226: 5222: 5218: 5211: 5203: 5199: 5194: 5189: 5185: 5181: 5178:(2): 849–56. 5177: 5173: 5172:Endocrinology 5169: 5162: 5154: 5150: 5146: 5142: 5137: 5132: 5129:(6): 540–51. 5128: 5124: 5120: 5113: 5105: 5101: 5096: 5091: 5088:(3): 483–93. 5087: 5083: 5079: 5072: 5064: 5058: 5054: 5047: 5039: 5035: 5030: 5025: 5021: 5017: 5013: 5009: 5005: 4998: 4990: 4986: 4982: 4978: 4974: 4970: 4965: 4960: 4957:(2): 95–105. 4956: 4952: 4948: 4941: 4933: 4929: 4925: 4921: 4914: 4906: 4902: 4898: 4894: 4890: 4886: 4882: 4878: 4871: 4863: 4859: 4855: 4851: 4847: 4843: 4840:(3): 277–82. 4839: 4835: 4828: 4820: 4816: 4812: 4808: 4804: 4800: 4793: 4785: 4781: 4776: 4771: 4767: 4763: 4759: 4752: 4744: 4740: 4736: 4732: 4724: 4716: 4712: 4708: 4704: 4700: 4696: 4688: 4680: 4676: 4672: 4668: 4664: 4660: 4653: 4645: 4641: 4636: 4631: 4627: 4623: 4620:(3): 766–74. 4619: 4615: 4611: 4604: 4597:(2): 969–974. 4596: 4592: 4585: 4577: 4571: 4567: 4560: 4552: 4548: 4544: 4540: 4537:(3): R624–9. 4536: 4532: 4525: 4523: 4514: 4510: 4507:(2): 705–11. 4506: 4502: 4495: 4487: 4483: 4479: 4475: 4470: 4465: 4461: 4457: 4453: 4446: 4438: 4434: 4430: 4426: 4421: 4416: 4413:(2): 271–90. 4412: 4408: 4404: 4397: 4389: 4385: 4381: 4377: 4373: 4369: 4365: 4361: 4354: 4346: 4342: 4337: 4332: 4328: 4324: 4320: 4316: 4312: 4305: 4297: 4293: 4289: 4285: 4280: 4275: 4272:(3): 409–18. 4271: 4267: 4263: 4256: 4248: 4244: 4239: 4234: 4230: 4226: 4222: 4218: 4214: 4207: 4199: 4195: 4190: 4185: 4181: 4177: 4174:(1): 96–106. 4173: 4169: 4168:Am. J. Pathol 4165: 4158: 4150: 4146: 4141: 4136: 4133:(3): 628–34. 4132: 4128: 4124: 4117: 4109: 4105: 4100: 4095: 4091: 4087: 4083: 4076: 4068: 4064: 4059: 4054: 4050: 4046: 4042: 4038: 4034: 4027: 4019: 4015: 4011: 4005: 4001: 3994: 3986: 3982: 3975: 3967: 3963: 3959: 3955: 3951: 3947: 3943: 3939: 3932: 3924: 3920: 3916: 3912: 3905: 3897: 3893: 3888: 3883: 3879: 3875: 3871: 3867: 3863: 3856: 3848: 3844: 3839: 3834: 3830: 3826: 3823:(6): 768–79. 3822: 3818: 3814: 3807: 3799: 3795: 3791: 3787: 3783: 3779: 3775: 3771: 3764: 3762: 3760: 3751: 3745: 3741: 3734: 3727: 3719: 3713: 3709: 3702: 3694: 3690: 3686: 3682: 3677: 3672: 3668: 3664: 3660: 3656: 3652: 3645: 3637: 3631: 3627: 3626: 3618: 3610: 3606: 3600: 3592: 3588: 3582: 3575: 3571: 3566: 3564: 3562: 3554: 3550: 3545: 3543: 3541: 3536: 3525: 3522: 3519: 3516: 3513: 3510: 3507: 3504: 3502: 3499: 3497: 3494: 3492: 3489: 3487: 3484: 3482: 3479: 3477: 3474: 3471: 3468: 3467: 3461: 3459: 3458:schizophrenia 3455: 3451: 3447: 3443: 3436:Human studies 3433: 3424: 3422: 3412: 3410: 3406: 3402: 3401:ciprofloxacin 3398: 3394: 3390: 3386: 3385:carbamazepine 3382: 3378: 3373: 3369: 3365: 3360: 3350: 3348: 3344: 3340: 3336: 3335:hypernatremia 3332: 3320: 3316: 3313: 3309: 3305: 3301: 3298: 3295: 3291: 3287: 3283: 3279: 3278:carbamazepine 3276: 3273: 3270: 3269: 3263: 3261: 3257: 3253: 3243: 3241: 3237: 3233: 3229: 3225: 3221: 3218:, trembling, 3217: 3213: 3209: 3205: 3201: 3191: 3189: 3185: 3181: 3177: 3173: 3169: 3165: 3161: 3151: 3149: 3145: 3141: 3137: 3132: 3130: 3126: 3122: 3118: 3117:haemophilia A 3114: 3110: 3105: 3103: 3098: 3096: 3090: 3074: 3070: 3068: 3065: 3059: 3058: 3055: 3052: 3050: 3047: 3041: 3040: 3036: 3034: 3031: 3025: 3024: 3021: 3017: 3013: 3009: 3005: 3003: 3000: 2994: 2993: 2990: 2987: 2985: 2982: 2976: 2975: 2972: 2969: 2967: 2964: 2958: 2957: 2954: 2952: 2947: 2944: 2941: 2938: 2932: 2931: 2928: 2925: 2923: 2920: 2914: 2913: 2910: 2907: 2905: 2902: 2896: 2895: 2892: 2889: 2887: 2884: 2878: 2877: 2874: 2870: 2866: 2862: 2858: 2854: 2852: 2849: 2843: 2842: 2839: 2835: 2831: 2829: 2825: 2819: 2818: 2815: 2811: 2808: 2805: 2799: 2795: 2791: 2790: 2787: 2783: 2779: 2776: 2773: 2767: 2763: 2759: 2758: 2755: 2751: 2749: 2746: 2740: 2739: 2736: 2732: 2728: 2724: 2721: 2718: 2715: 2709: 2708: 2705: 2701: 2698: 2695: 2689: 2685: 2681: 2680: 2677: 2675: 2670: 2667: 2666: 2662: 2659: 2654: 2649: 2647: 2643: 2639: 2638:primary amide 2635: 2631: 2623: 2619: 2615: 2611: 2607: 2603: 2599: 2595: 2591: 2587: 2583: 2575: 2570: 2563: 2559: 2555: 2550: 2537: 2533: 2531: 2527: 2525: 2521: 2517: 2513: 2509: 2506:Insertion of 2505: 2502: 2498: 2496: 2492: 2489: 2487: 2484: 2483: 2480: 2478: 2475: 2472: 2470: 2466: 2463: 2461: 2457: 2454: 2452: 2449: 2448: 2445: 2443: 2440: 2437: 2433: 2429: 2425: 2421: 2418: 2416: 2412: 2408: 2405: 2403: 2399: 2396: 2394: 2391: 2390: 2386: 2383: 2380: 2377: 2375: 2372: 2369: 2368: 2365: 2357: 2355: 2351: 2341: 2339: 2335: 2331: 2327: 2322: 2319: 2315: 2311: 2307: 2303: 2298: 2296: 2295:baroreceptors 2292: 2291:heart failure 2288: 2284: 2280: 2267: 2264: 2261: 2258: 2255: 2252: 2249: 2246: 2245: 2244: 2241: 2239: 2235: 2231: 2227: 2223: 2219: 2215: 2211: 2209: 2202: 2184: 2181: 2178: 2174: 2170: 2169: 2168: 2160: 2158: 2154: 2150: 2146: 2138: 2134: 2133:distal tubule 2130: 2126: 2125:loop of Henle 2122: 2118: 2115: 2111: 2107: 2103: 2099: 2095: 2091: 2088: 2084: 2079: 2075: 2071: 2066: 2065: 2064: 2056: 2054: 2050: 2046: 2042: 2038: 2033: 2031: 2027: 2022: 2020: 2016: 2011: 2010:hypertonicity 2007: 1996: 1986: 1983: 1981: 1976: 1974: 1970: 1966: 1962: 1957: 1955: 1951: 1947: 1943: 1939: 1935: 1931: 1927: 1926:hypertonicity 1923: 1919: 1915: 1911: 1907: 1903: 1900: 1896: 1892: 1888: 1884: 1880: 1876: 1872: 1868: 1855: 1850: 1846: 1842: 1839: 1835: 1828: 1826: 1823: 1819: 1815: 1811: 1808: 1804: 1800: 1793: 1791: 1785: 1781: 1778: 1772: 1770: 1764: 1760: 1757: 1753: 1746: 1744: 1738: 1734: 1731: 1725: 1723: 1717: 1713: 1710: 1708:RefSeq (mRNA) 1706: 1699: 1698: 1693: 1689: 1686: 1680: 1679: 1674: 1670: 1667: 1665: 1661: 1654: 1653: 1648: 1644: 1641: 1635: 1634: 1629: 1625: 1622: 1620: 1616: 1609: 1608: 1603: 1599: 1596: 1590: 1589: 1584: 1580: 1577: 1575: 1571: 1568: 1565: 1563: 1560: 1556: 1553: 1549: 1545: 1538: 1534: 1529: 1523: 1520: 1518: 1515: 1513: 1510: 1508: 1505: 1503: 1500: 1498: 1495: 1493: 1490: 1488: 1485: 1483: 1480: 1478: 1475: 1473: 1470: 1468: 1465: 1463: 1460: 1458: 1455: 1453: 1450: 1448: 1445: 1443: 1440: 1438: 1435: 1433: 1430: 1428: 1425: 1423: 1420: 1418: 1415: 1413: 1410: 1408: 1405: 1403: 1400: 1398: 1395: 1393: 1390: 1388: 1385: 1383: 1380: 1378: 1375: 1373: 1370: 1368: 1365: 1363: 1360: 1358: 1355: 1353: 1350: 1348: 1345: 1343: 1340: 1338: 1335: 1333: 1330: 1328: 1325: 1324: 1322: 1319: 1318: 1312: 1309: 1307: 1304: 1302: 1299: 1297: 1294: 1292: 1289: 1287: 1284: 1283: 1281: 1278: 1277: 1271: 1268: 1266: 1263: 1261: 1258: 1256: 1253: 1251: 1248: 1246: 1243: 1241: 1238: 1236: 1233: 1232: 1230: 1227: 1226: 1223: 1222:Gene ontology 1219: 1215: 1203: 1198: 1194: 1189: 1186: 1184: 1180: 1172: 1167: 1156: 1152: 1148: 1144: 1140: 1136: 1132: 1128: 1124: 1120: 1119: 1116: 1112: 1107: 1104: 1094: 1090: 1086: 1082: 1078: 1074: 1071:apex of heart 1070: 1066: 1062: 1058: 1057: 1054: 1050: 1045: 1042: 1041: 1038: 1036: 1032: 1030: 1029: 1025: 1024: 1021: 1019: 1015: 1011: 1007: 1003: 995: 990: 986: 982: 977: 967: 963: 956: 949: 943: 936: 928: 924: 920: 915: 911: 906: 902: 894: 889: 885: 881: 876: 866: 862: 855: 848: 842: 835: 831: 825: 821: 817: 812: 808: 803: 799: 795: 791: 787: 783: 779: 775: 771: 767: 763: 759: 751: 746: 739: 734: 729: 725: 720: 715: 702: 697: 696: 693: 686: 677: 676: 673: 666: 662: 660: 656: 649: 645: 644: 642: 639: 634: 623: 621: 617: 584: 582: 578: 573: 565: 561: 560:DTXSID0048349 557: 556: 554: 545: 541: 534: 530: 529: 527: 525: 521: 514: 510: 509: 507: 505: 501: 494: 490: 489: 487: 485: 481: 474: 470: 469: 467: 465: 461: 454: 450: 449: 447: 445: 441: 434: 430: 429: 427: 425: 421: 414: 410: 409: 407: 405: 401: 394: 390: 389: 387: 380: 376: 369: 365: 364: 362: 360: 356: 347: 346: 343: 336: 331: 327: 325: 321: 318:10–20 minutes 317: 315: 308: 305: 301: 297: 295: 291: 287: 285: 281: 277: 273: 270: 266: 262: 260: 256: 253: 250: 248: 244: 241: 237: 234: 232: 228: 225: 221: 214: 207: 201: 199: 195: 191: 187: 184: 180: 177: 175: 170: 166: 165:Physiological 162: 154: 149: 146: 145: 143: 141: 137: 133: 129: 123: 79: 77:Pronunciation 75: 72:Clinical data 70: 66: 61: 57: 52: 42: 35: 30: 19: 9240:Nonapeptides 9166: 9133: 9094:Antagonists: 9093: 9043:JNJ-17079166 9035:Antagonists: 9034: 9022: 9018:Terlipressin 8988:Desmopressin 8984: 8960: 8954:TASP-0390325 8949:TASP-0233278 8921:Antagonists: 8920: 8908: 8904:Terlipressin 8884:Desmopressin 8880: 8805:JNJ-17308616 8800:JNJ-17079166 8777:Antagonists: 8776: 8764: 8760:Terlipressin 8736: 8665: 8601:Non-peptide: 8600: 8588: 8586:Antagonists: 8585: 8556:Non-peptide: 8555: 8493: 8490: 8390:Acetaldehyde 8059: 8051: 8023: 8015: 7993:Trace amines 7671:Neurophysins 7499:Neurokinin B 7494:Neurokinin A 7330:Endomorphins 7256: 6950: 6856:Solvent drag 6849:Reabsorption 6504:Thymopoietin 6440:Pineal gland 6425:Somatostatin 6388:Progesterone 6335:Progesterone 6302:Testosterone 6285:Gonadal axis 6257:Thyroid axis 6154:Adrenal axis 6069: 6009:Hypothalamus 5934: 5919: 5904: 5889: 5831:. Retrieved 5827:the original 5811: 5766: 5762: 5756: 5719: 5715: 5705: 5675:(4): 425–8. 5672: 5668: 5662: 5627: 5623: 5589: 5585: 5579: 5568:. Retrieved 5513: 5509: 5503: 5478: 5474: 5468: 5433: 5429: 5419: 5388: 5378: 5354: 5347: 5312: 5308: 5298: 5271: 5267: 5257: 5224: 5220: 5210: 5175: 5171: 5161: 5126: 5122: 5112: 5085: 5081: 5071: 5052: 5046: 5011: 5007: 4997: 4954: 4950: 4940: 4923: 4919: 4913: 4880: 4876: 4870: 4837: 4833: 4827: 4802: 4798: 4792: 4765: 4761: 4751: 4734: 4730: 4723: 4701:(7): 852–9. 4698: 4694: 4687: 4662: 4658: 4652: 4617: 4613: 4603: 4594: 4590: 4584: 4565: 4559: 4534: 4530: 4504: 4500: 4494: 4462:(1): 57–68. 4459: 4455: 4445: 4410: 4406: 4396: 4363: 4359: 4353: 4318: 4314: 4304: 4269: 4265: 4255: 4220: 4216: 4206: 4171: 4167: 4157: 4130: 4126: 4116: 4089: 4085: 4075: 4040: 4036: 4026: 3999: 3993: 3984: 3974: 3944:(1): 35–45. 3941: 3938:Neuroscience 3937: 3931: 3914: 3904: 3869: 3865: 3855: 3820: 3816: 3806: 3773: 3769: 3739: 3726: 3707: 3701: 3658: 3654: 3644: 3624: 3617: 3608: 3599: 3590: 3581: 3501:Hypothalamus 3439: 3430: 3418: 3405:moxifloxacin 3362: 3328: 3266:Interactions 3254:and chronic 3249: 3197: 3194:Side effects 3157: 3136:septic shock 3133: 3121:Terlipressin 3115:and in mild 3109:desmopressin 3106: 3099: 3092: 3049:Cephalotocin 2951:Invertebrate 2949: 2797: 2793: 2785: 2780:Non-mammals 2765: 2761: 2748:Phenypressin 2687: 2683: 2672: 2664: 2663: 2650: 2633: 2579: 2530:desmopressin 2387:Antagonists 2363: 2347: 2323: 2318:infundibulum 2299: 2279:blood volume 2276: 2242: 2237: 2233: 2207: 2204: 2166: 2142: 2083:V2 receptors 2070:antidiuresis 2062: 2053:desmopressin 2044: 2040: 2036: 2034: 2030:prairie vole 2023: 2003: 1984: 1977: 1973:pair bonding 1958: 1910:hypothalamus 1886: 1882: 1878: 1874: 1870: 1866: 1864: 1787: 1766: 1740: 1719: 1695: 1676: 1650: 1631: 1605: 1586: 1566: 1561: 1075:human kidney 1059:hypothalamus 1033: 1026: 992:130,424,474 979:130,422,540 753:External IDs 533:ChEMBL373742 311:Elimination 240:desmopressin 41:vasopressors 29: 9170:Neurophysin 9008:Ornipressin 8993:Felypressin 8934:Brezivaptan 8899:Ornipressin 8889:Felypressin 8825:Relcovaptan 8755:Selepressin 8750:Ornipressin 8740:Felypressin 8717:Vasopressin 8687:-Methionine 8537:PF-06478939 8512:Demoxytocin 8395:Ammonia (NH 8266:Nucleosides 8026:-Octopamine 8018:-Octopamine 7930:T-HCA (GHC) 7887:Hypotaurine 7839:GABA system 7790:Glutathione 7676:Neurotensin 7586:Angiotensin 7525:Neuromedins 7514:Physalaemin 7489:Substance P 7483:Tachykinins 7478:Bradykinins 7425:Hemorphin-4 7410:Adrenorphin 7381:Enkephalins 7371:γ-Endorphin 7366:β-Endorphin 7361:α-Endorphin 7300:Dynorphin B 7290:Dynorphin A 7285:Dynorphin A 7194:Natriuresis 7059:Delta ratio 7045:Base excess 6956:Aldosterone 6688:Osteocalcin 6665:Adiponectin 6492:Thymosin α1 6267:Parathyroid 6167:Aldosterone 6070:Vasopressin 5872:PDB gallery 3872:(3): 3790. 3399:(including 3393:vincristine 3083:Medical use 3067:Octopressin 2909:Bony fishes 2873:coelacanths 2697:Argipressin 2586:amino acids 2556:at the 8th 2508:aquaporin-2 2442:Felypressin 2432:factor VIII 2426:breakdown, 2254:Angiotensin 2157:aquaporin 2 2076:) into the 2074:Aquaporin-2 1934:circulation 1887:argipressin 1867:vasopressin 1133:optic nerve 1083:left testis 731:Identifiers 631: g·mol 333:Identifiers 247:Antagonists 236:Felypressin 192:System-wide 131:Other names 48:Vasopressin 9194:Categories 9107:RWJ-339489 9102:Ribuvaptan 9097:Balovaptan 9063:Satavaptan 9058:RWJ-351647 9053:Mozavaptan 9048:Lixivaptan 9038:Conivaptan 8939:Nelivaptan 8845:WAY-267464 8790:Conivaptan 8785:Balovaptan 8659:WAY-162720 8654:SSR-126768 8609:Cligosiban 8574:WAY-267464 8527:Nacartocin 8507:Cargutocin 8502:Carbetocin 8497:Aspartocin 8475:modulators 8383:Candidates 8257:Nucleobase 8046:Tryptamine 8041:Synephrine 7952:Monoamines 7917:GHB system 7750:Amino acid 7505:amphibian 7442:Spinorphin 7432:Nociceptin 7415:Amidorphin 7353:Endorphins 7310:Leumorphin 7277:Dynorphins 7069:Buffering 6997:Body water 6976:Calcitriol 6896:Filtration 6716:Calcitriol 6602:Peptide YY 6252:Calcitonin 6204:Adrenaline 6133:Lipotropin 6128:Endorphins 5833:2008-12-08 5570:2017-03-13 4926:: 99–108. 3915:StatPearls 3864:. review. 3576:, May 2017 3555:, May 2017 3531:References 3524:Baroreflex 3349:(thirst). 3347:polydipsia 3325:Deficiency 3286:clofibrate 3232:flatulence 3012:pond snail 3008:cone snail 2922:Glumitocin 2869:lungfishes 2865:amphibians 2754:marsupials 2735:marsupials 2699:(AVP, ADH) 2674:Vertebrate 2558:amino acid 2516:P-selectin 2312:(PVN) and 2190:Regulation 1989:Physiology 1946:arterioles 1902:prohormone 1037:(ortholog) 891:3,084,724 878:3,082,556 774:HomoloGene 636:3D model ( 620:Molar mass 513:CHEBI:9937 473:Y87Y826H08 444:ChemSpider 404:IUPHAR/BPS 368:11000-17-2 359:CAS Number 342:IUPAC name 294:Metabolism 259:Metabolism 9127:YM-222546 9068:Tolvaptan 9003:Lypressin 8985:Agonists: 8894:Lypressin 8881:Agonists: 8820:PF-184563 8815:LY-307174 8795:FR-218944 8745:Lypressin 8737:Agonists: 8707:Puromycin 8692:Leupeptin 8669:Amastatin 8649:Retosiban 8644:Nolasiban 8639:L-372,662 8634:L-371,257 8629:L-368,899 8619:Erlosiban 8614:Epelsiban 8604:Barusiban 8522:Merotocin 8491:Agonists: 8274:Adenosine 8078:Histamine 8062:-Tyramine 8054:-Tyramine 7897:Sarcosine 7877:β-Alanine 7872:α-Alanine 7616:FMRFamide 7601:Carnosine 7485:: mammal 7447:Valorphin 7437:Opiorphin 7420:Hemorphin 7055:Anion gap 6825:Clearance 6818:Secretion 6808:Creating 6487:Thymosins 6448:Melatonin 6330:Estradiol 6177:Cortisone 6103:Prolactin 6000:pituitary 5987:Endocrine 5632:CiteSeerX 5586:Radiology 4989:223606053 4388:205434100 4092:: 82–92. 4018:951680737 3442:nootropic 3228:diarrhoea 3208:heartburn 3200:dizziness 3176:half life 2989:Earthworm 2984:Annetocin 2886:Seritocin 2851:Mesotocin 2775:Vasotocin 2717:Lypressin 2536:tolvaptan 2384:Agonists 2378:Locations 2360:Receptors 2287:nephrosis 2283:cirrhosis 2153:threonine 2045:lypressin 1790:NP_033862 1769:NP_000481 1743:NM_009732 1722:NM_000490 1552:Orthologs 782:GeneCards 324:Excretion 313:half-life 252:Diuretics 198:Receptors 9122:VMAX-382 9117:VMAX-372 9112:VMAX-367 9087:Unsorted 9078:YM-35471 9013:TC OT 39 8964:TASP-699 8961:Ligands: 8860:YM-35471 8840:TC OT 39 8780:Atosiban 8592:Atosiban 8589:Peptide: 8569:TC OT 39 8532:Oxytocin 8494:Peptide: 8483:Oxytocin 8468:Oxytocin 8313:-derived 8259:-derived 8240:instead. 8195:Oleamide 8126:-derived 8107:instead. 7964:Dopamine 7775:Agmatine 7752:-derived 7591:Bombesin 7509:Kassinin 7259:hormones 7252:Hormones 7241:Peptides 6944:Hormones 6866:Chloride 6680:Skeleton 6670:Resistin 6569:Secretin 6551:Duodenum 6509:Thymulin 6410:Glucagon 6402:Pancreas 6383:Estrogen 6365:Placenta 6172:Cortisol 6065:Oxytocin 6027:Dopamine 5979:Hormones 5783:29468985 5748:25853137 5697:31960688 5689:19596026 5654:17981159 5538:12739464 5495:15280526 5460:18057218 5339:10880054 5249:38444963 5241:15555506 5202:17122081 5153:29923520 5145:17083331 5104:14647484 5038:15650630 4985:ProQuest 4973:15010588 4932:14175989 4905:43764321 4862:37668345 4743:18758414 4715:25130060 4551:21123762 4437:14991100 4380:22119947 4345:27450627 4321:: 5–17. 4247:21900458 4198:23123217 4149:10073614 4108:21686211 4067:23584881 3966:16210017 3958:15051143 3923:30252325 3896:26913138 3847:20346754 3798:36759747 3790:24259701 3693:35174328 3572:– 3551:– 3491:Copeptin 3476:Oxytocin 3464:See also 3389:oxytocin 3343:polyuria 3260:polyuria 3216:vomiting 3144:dopamine 3071:Octopus 3016:sea hare 2966:Inotocin 2904:Isotocin 2861:reptiles 2828:Oxytocin 2807:Oxytocin 2792:Cys-Tyr- 2760:Cys-Tyr- 2731:warthogs 2682:Cys-Tyr- 2653:oxytocin 2632:and the 2582:peptides 2574:oxytocin 2554:arginine 2428:platelet 2424:glycogen 2381:Actions 2266:Cortisol 2216:(TTFL), 2201:AVP gene 2006:tonicity 2000:Function 1942:nephrons 1922:vesicles 1895:AVP gene 1838:Wikidata 1531:Sources: 1311:dendrite 1087:amygdala 1079:monocyte 424:DrugBank 231:Agonists 140:ATC code 9142:Lithium 8998:LIT-001 8929:ABT-558 8924:ABT-436 8810:LIT-001 8564:LIT-001 8311:Vitamin 8205:RVD-Hpα 8160:AA-5-HT 7907:Taurine 7892:Proline 7882:Glycine 7825:Proline 7795:Glycine 7691:RVD-Hpα 7636:Ghrelin 7621:Galanin 7557:Orexins 6886:Protein 6876:Glucose 6574:Motilin 6541:Ghrelin 6536:Gastrin 6528:Stomach 6415:Insulin 6350:Relaxin 6345:Inhibin 6340:Activin 6312:Inhibin 6221:Thyroid 5791:3465601 5739:4371647 5606:5101576 5530:7556852 5451:2396735 5290:7545469 5193:2040022 5029:1356906 4981:3369276 4920:Surgery 4897:4084755 4854:3168310 4784:8390330 4679:2360697 4644:2830315 4513:1941619 4486:6916996 4478:9989497 4429:9988221 4336:5203950 4296:2295415 4288:9639350 4238:3233874 4189:3532715 4099:3116377 4058:3775849 3887:4756744 3838:2847497 3685:8277003 3676:9883978 3574:Ensembl 3553:Ensembl 3472:(SIADH) 3415:History 3308:heparin 3300:lithium 3272:alcohol 3188:kidneys 3142:(e.g., 3054:Octopus 2814:ratfish 2800:-Gly-NH 2768:-Gly-NH 2733:, some 2704:mammals 2690:-Gly-NH 2460:calcium 2402:calcium 2308:in the 2248:Ethanol 1940:of the 1908:in the 1906:neurons 1899:peptide 1891:hormone 1889:, is a 1664:UniProt 1619:Ensembl 1558:Species 1537:QuickGO 1291:cytosol 1012:pattern 738:Aliases 659:Density 581:Formula 433:DB00067 379:PubChem 304:kidneys 269:kidneys 174:tissues 172:Source 156:) 150: ( 148:H01BA01 9230:Orgasm 9160:Others 9073:YM-471 8855:YM-471 8850:YM-218 8835:SRX251 8830:SRX246 8579:WJ0679 8276:system 8150:2-ALPI 8071:Others 7902:Serine 7830:Serine 7470:Kinins 7403:Others 7017:Plasma 6861:Sodium 6698:Kidney 6660:Leptin 6619:/other 6479:Thymus 6420:Amylin 6294:Testis 6187:DHEA-S 5989:glands 5819:  5789:  5781:  5746:  5736:  5722:: 19. 5695:  5687:  5652:  5634:  5604:  5536:  5528:  5493:  5458:  5448:  5407:  5366:  5337:  5330:314363 5327:  5288:  5247:  5239:  5200:  5190:  5151:  5143:  5102:  5059:  5036:  5026:  4987:  4979:  4971:  4930:  4903:  4895:  4860:  4852:  4819:646620 4817:  4782:  4741:  4713:  4677:  4642:  4635:442524 4632:  4572:  4549:  4511:  4484:  4476:  4435:  4427:  4386:  4378:  4343:  4333:  4294:  4286:  4245:  4235:  4196:  4186:  4147:  4106:  4096:  4065:  4055:  4016:  4006:  3964:  3956:  3921:  3894:  3884:  3845:  3835:  3817:Neuron 3796:  3788:  3746:  3714:  3691:  3683:  3673:  3632:  3456:, and 3446:autism 3368:cancer 3353:Excess 3339:sodium 3212:nausea 3204:angina 3170:. 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Index

Arginine vasopressin
Vasopressin (medication)
vasopressors


/ˌvzˈprɛsɪn/
ATC code
H01BA01
WHO
Physiological
tissues
Supraoptic nucleus
paraventricular nucleus of hypothalamus
Receptors
V1A
V1B
V2
OXTR
Agonists
Felypressin
desmopressin
Antagonists
Diuretics
Metabolism
liver
kidneys
Pharmacokinetic
Protein binding
Metabolism
liver

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