267:(PABA). PABA is needed in enzymatic reactions that produce folic acid, which acts as a coenzyme in the synthesis of purines and pyrimidines, the building-blocks of DNA. Mammals do not synthesize their own folic acid so they are unaffected by PABA inhibitors, which selectively kill bacteria. Sulfanilamide drugs are not like the antibiotics used to treat infections. Instead, they work by changing the DNA inside cancer cells to keep them from growing and multiplying. Antitumor antibiotics are a class of antimetabolite drugs that are cell cycle nonspecific. They act by binding with DNA molecules and preventing RNA (ribonucleic acid) synthesis, a key step in the creation of proteins, which are necessary for cancer cell survival.
33:
533:
109:, as they interfere with DNA production and therefore cell division and tumor growth. Because cancer cells spend more time dividing than other cells, inhibiting cell division harms tumor cells more than other cells. Antimetabolite drugs are commonly used to treat leukemia, cancers of the breast, ovary, and the gastrointestinal tract, as well as other types of cancers. In the
495:. This means these are the same bases as above, but with an added sugar group. For the nucleoside analogues either the base or the sugar component can be altered. They are similar enough to the molecules used to build cellular DNA that they are incorporated by the cell into its DNA, but different enough that after being added the cell's DNA they stop cell growth.
517:. This means these molecules look exactly like the pieces used to build DNA in a cell and can be incorporated into a growing cell's DNA. However, because they are analogues and therefore slightly different from regular nucleotides, causing the cell's growth to be halted and the cell to die.
407:. This means that these molecules are structurally similar enough to the basic components of DNA that they can be substituted in. However, since they are slightly different from the normal bases after they are incorporated into the DNA, the DNA production is halted and the cell dies.
116:
Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation.
794:
Mashita T, Kowada T, Takahashi H, Matsui T, Mizukami S (June 2019). "Light-Wavelength-Based
Quantitative Control of Dihydrofolate Reductase Activity by Using a Photochromic Isostere of an Inhibitor".
243:, the cell death process. Because of this mode of action, most antimetabolites have high cell cycle specificity and can target arrest of cancer cell DNA replication.
2658:
589:
Peters GJ, van der Wilt CL, van
Moorsel CJ, Kroep JR, Bergman AM, Ackland SP (2000). "Basis for effective combination cancer chemotherapy with antimetabolites".
662:
Matera C, Gomila AM, Camarero N, Libergoli M, Soler C, Gorostiza P (November 2018). "Photoswitchable
Antimetabolite for Targeted Photoactivated Chemotherapy".
645:
110:
718:
1070:
2718:
1770:
1599:
1579:
1564:
2795:
204:, chemicals that become the building-blocks of DNA. They prevent these substances from becoming incorporated into DNA during the
729:
1986:
1039:
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1063:
573:
2353:
1505:
1461:
1339:
1048:
1264:
985:
2763:
1056:
532:
1780:
17:
2399:
1401:
1291:
212:), stopping normal development and cell division. Anti-metabolites also affect RNA synthesis. However, because
715:
2321:
2304:
2179:
1943:
1321:
362:
235:
that participate in essential biosynthetic processes and subsequent incorporation of these biomolecules into
2053:
1649:
623:
2255:
270:
Anthracyclines are anti-tumor antibiotics that interfere with enzymes involved in copying DNA during the
64:. Such substances are often similar in structure to the metabolite that they interfere with, such as the
1645:
1615:
1435:
1540:
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2501:
2491:
776:
887:
2790:
2673:
2606:
2576:
2194:
1444:
1001:
Leumann CJ (April 2002). "DNA analogues: from supramolecular principles to biological properties".
627:
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2476:
2191:
1677:
1525:
1452:
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2546:
2279:
2121:
1043:
264:
73:
1828:
1475:
358:
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2103:
1624:
221:
8:
2511:
2411:
2390:
2111:
1933:
1765:
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1392:
927:"The use of antimetabolites as adjunctive therapy in the surgical treatment of pterygium"
498:
480:
444:
1569:
1078:
953:
926:
907:
863:
838:
819:
697:
120:
Examples of cancer drug antimetabolites include, but are not limited to the following:
1014:
903:
888:"Surgical Approaches and Antimetabolite Use in Dacryocystorhinostomy: A Meta-Analysis"
602:
2693:
2267:
1101:
1018:
981:
958:
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811:
726:
689:
606:
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260:
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911:
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803:
679:
671:
598:
166:
106:
2137:
2099:
1890:
1312:
1227:
839:"National survey of antimetabolite use in glaucoma surgery in the United Kingdom"
733:
722:
410:
2757:
2291:
1882:
1376:
1127:
1097:
1084:
463:
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343:
197:
132:
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1961:
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2016:
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89:
37:
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Gage-White L, LaMear WR, Paleri V, Robson A, Bearn (August 1, 2003).
514:
422:
418:
377:
312:
240:
213:
40:(bottom) is an antimetabolite that interferes with the metabolism of
376:(5-FU), is currently being tested for its effectiveness of managing
2637:
2601:
2541:
2309:
2247:
2027:
1923:
1895:
1574:
1411:
452:
354:
347:
77:
588:
527:(vitamin B9) which is needed to build DNA and allow cells to grow.
1530:
1431:
1245:
1106:
456:
205:
342:(MMC), are commonly used in America and Japan as an addition to
1170:
414:
232:
217:
189:
227:
Due to their efficiency, these drugs are the most widely used
836:
661:
510:
492:
885:
793:
769:
303:
Anti-tumor antibiotics that are not anthracyclines include:
837:
Siriwardena D, Edmunds B, Wormald RP, Khaw PT (July 2004).
969:
640:
638:
636:
239:, inhibits their normal tumor cell function and triggers
725:
in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds)
220:
is used instead), inhibition of thymidine synthesis via
76:
can occur, and the presence of antimetabolites can have
566:
Oxford dictionary of biochemistry and molecular biology
224:
selectively inhibits DNA synthesis over RNA synthesis.
113:
antimetabolite cancer drugs are classified under L01B.
924:
633:
357:
of operative sites. Thus, its use following external
111:
763:
The
Organic Chemistry of Drug Design and Drug Action
60:, which is another chemical that is part of normal
657:
655:
368:Intraoperative antimetabolite application, namely
787:
2782:
745:
568:. Oxford : Oxford University Press. p. 43.
399:) – structures that can substitute for a normal
727:Cancer Management: A Multidisciplinary Approach
652:
739:
27:Chemical that inhibits the use of a metabolite
1064:
994:
451:, the smaller bases incorporated into DNA as
925:Kareem AA, Farhood QK, Alhammami HA (2012).
417:, the larger bases incorporated into DNA as
353:Antimetabolites have been shown to decrease
1071:
1057:
952:
942:
862:
760:
716:"Principles of Oncologic Pharmacotherapy"
683:
626:at the U.S. National Library of Medicine
980:. New York: John Wiley & Sons, Inc.
664:Journal of the American Chemical Society
388:Main categories of these drugs include:
263:synthesis in bacteria by competing with
31:
1000:
975:
748:Medicinal Chemistry of Anticancer Drugs
231:. Competition for the binding sites of
14:
2783:
523:– chemicals that block the actions of
1052:
563:
216:is used in DNA but not in RNA (where
1003:Bioorganic & Medicinal Chemistry
892:Otolaryngology–Head and Neck Surgery
843:The British Journal of Ophthalmology
361:, a procedure for the management of
277:Examples of anthracyclines include:
1340:ribonucleotide reductase inhibitors
447:– mimic the structure of metabolic
413:– mimic the structure of metabolic
100:
24:
1506:Ribonucleotide reductase inhibitor
1462:Ribonucleotide reductase inhibitor
80:effects on cells, such as halting
25:
2807:
1265:Dihydrofolate reductase inhibitor
1033:
750:(2nd ed.). Elsevier Science.
188:Anti-metabolites masquerade as a
88:, so these compounds are used in
746:Avendano C, Menendez CJ (2015).
531:
346:, a surgical procedure to treat
918:
879:
830:
591:Pharmacology & Therapeutics
505:alternatives that consist of a
487:alternatives that consist of a
105:Antimetabolites can be used in
68:that interfere with the use of
2796:Antineoplastic antimetabolites
1402:Thymidylate synthase inhibitor
1292:Thymidylate synthase inhibitor
754:
708:
624:Antineoplastic+Antimetabolites
617:
582:
557:
338:Antimetabolites, particularly
246:
13:
1:
1322:Adenosine deaminase inhibitor
1163:Block microtubule disassembly
1015:10.1016/S0968-0896(01)00348-0
904:10.1016/S0194-5998(03)01253-1
777:"Types of Chemotherapy Drugs"
646:"How Chemotherapy Drugs Work"
603:10.1016/S0163-7258(00)00086-3
550:
363:nasolacrimal duct obstruction
333:
251:Antimetabolites may also be
7:
538:
95:
10:
2812:
978:A Study of Antimetabolites
648:. American Cancer Society.
2741:
2622:Omacetaxine mepesuccinate
2502:Ciltacabtagene autoleucel
2492:Brexucabtagene autoleucel
2438:
2389:
2169:
2162:
2098:
2052:
1985:
1942:
1779:
1764:
1644:
1614:
1539:
1524:
1495:
1391:
1311:
1254:
1237:
1226:
1162:
1115:
1096:
976:Woolley DW (March 1987).
2674:Talimogene laherparepvec
2607:Nadofaragene firadenovec
2577:Lisocabtagene maraleucel
1526:Topoisomerase inhibitors
1445:DNA polymerase inhibitor
628:Medical Subject Headings
383:
2477:Axicabtagene ciloleucel
1081:chemotherapeutic agents
855:10.1136/bjo.2003.034256
365:, is being researched.
2659:Sitimagene ceradenovec
2557:Idecabtagene vicleucel
2122:Methyl aminolevulinate
1044:University of Nebraska
931:Clinical Ophthalmology
808:10.1002/cbic.201800816
714:Takimoto CH, Calvo E.
265:para-aminobenzoic acid
74:competitive inhibition
45:
2133:Porphyrin derivatives
1829:Melphalan flufenamide
1476:Hypomethylating agent
1085:antineoplastic agents
781:SEER Training Modules
761:Silverman RB (2004).
359:dacryocystorhinostomy
259:drugs, which inhibit
35:
2462:Asparagine depleters
2391:Receptor antagonists
2305:+abiraterone acetate
676:10.1021/jacs.8b08249
499:nucleotide analogues
481:nucleoside analogues
445:pyrimidine analogues
222:thymidylate synthase
2512:Denileukin diftitox
2412:Retinoid X receptor
2112:Aminolevulinic acid
1934:Triethylenemelamine
1766:Crosslinking of DNA
1497:Deoxyribonucleotide
1436:+gimeracil/oteracil
944:10.2147/OPTH.S38388
670:(46): 15764–15773.
52:is a chemical that
2768:Never to phase III
1570:Etirinotecan pegol
732:2013-10-04 at the
721:2020-05-03 at the
46:
2778:
2777:
2737:
2736:
2694:Tigilanol tiglate
2171:Enzyme inhibitors
2094:
2093:
2090:
2089:
1790:Nitrogen mustards
1760:
1759:
1520:
1519:
1222:
1221:
802:(11): 1382–1386.
575:978-0-19-854768-6
564:Smith AL (1997).
16:(Redirected from
2803:
2699:Tisagenlecleucel
2456:Arsenic trioxide
2167:
2166:
2100:Photosensitizers
1891:Alkyl sulfonates
1805:Cyclophosphamide
1777:
1776:
1716:Anthracenediones
1537:
1536:
1511:Hydroxycarbamide
1252:
1251:
1235:
1234:
1113:
1112:
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1066:
1059:
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597:(2–3): 227–253.
586:
580:
579:
561:
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411:purine analogues
167:Hydroxycarbamide
107:cancer treatment
101:Cancer treatment
21:
2811:
2810:
2806:
2805:
2804:
2802:
2801:
2800:
2791:Antimetabolites
2781:
2780:
2779:
2774:
2773:
2758:Clinical trials
2733:
2439:Other/ungrouped
2434:
2385:
2158:
2138:Porfimer sodium
2086:
2048:
1981:
1938:
1768:
1756:
1640:
1610:
1528:
1516:
1491:
1387:
1307:
1243:
1241:antimetabolites
1239:
1238:DNA precursors/
1230:
1228:DNA replication
1218:
1158:
1128:Vinca alkaloids
1104:
1092:
1077:
1036:
1031:
1030:
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995:
988:
974:
970:
923:
919:
884:
880:
835:
831:
792:
788:
775:
774:
770:
765:(2nd ed.).
759:
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734:Wayback Machine
723:Wayback Machine
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491:analogue and a
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336:
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18:Antimetabolites
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2292:PARP inhibitor
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2019:
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1997:
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1944:Platinum-based
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1659:Anthracyclines
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1377:Mercaptopurine
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1094:
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1079:Intracellular
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1068:
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1053:
1047:
1046:
1035:
1034:External links
1032:
1029:
1028:
1009:(4): 841–854.
993:
986:
968:
917:
878:
849:(7): 873–876.
829:
786:
768:
753:
738:
736:. 11 ed. 2008.
707:
651:
632:
616:
581:
574:
555:
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552:
549:
548:
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540:
537:
529:
528:
518:
496:
478:
477:
476:
475:
474:
464:5-Fluorouracil
442:
441:
440:
393:base analogues
385:
382:
374:5-fluorouracil
344:trabeculectomy
335:
332:
331:
330:
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198:mercaptopurine
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133:Mercaptopurine
129:
102:
99:
97:
94:
50:antimetabolite
26:
9:
6:
4:
3:
2:
2808:
2797:
2794:
2792:
2789:
2788:
2786:
2767:
2765:
2762:
2761:
2759:
2756:
2753:
2750:
2748:
2745:
2744:
2740:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2649:
2646:
2644:
2640:
2639:
2635:
2633:
2632:Tabelecleucel
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2592:Lurbinectedin
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2472:
2468:
2464:
2463:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2443:
2441:
2437:
2430:
2426:
2425:
2421:
2418:
2414:
2413:
2409:
2406:
2402:
2401:
2397:
2396:
2394:
2392:
2388:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2357:
2355:
2351:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2324:
2323:
2319:
2316:
2313:
2311:
2308:
2306:
2303:
2300:
2298:
2294:
2293:
2289:
2286:
2282:
2281:
2277:
2274:
2270:
2269:
2265:
2262:
2258:
2257:
2253:
2249:
2246:
2244:
2241:
2239:
2236:
2234:
2231:
2230:
2229:
2228:
2224:
2221:
2218:
2216:
2213:
2211:
2208:
2206:
2203:
2201:
2197:
2196:
2193:
2189:
2186:
2182:
2181:
2177:
2176:
2174:
2172:
2168:
2165:
2161:
2154:
2151:
2149:
2146:
2144:
2141:
2139:
2135:
2134:
2130:
2128:
2125:
2123:
2120:
2118:
2115:
2113:
2110:
2109:
2107:
2105:
2101:
2097:
2082:
2079:
2077:
2074:
2072:
2069:
2067:
2063:
2060:
2059:
2057:
2055:
2054:Intercalation
2051:
2044:
2041:
2039:
2036:
2034:
2030:
2029:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2007:
2003:
2002:
1998:
1996:
1993:
1992:
1990:
1988:
1984:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1962:Dicycloplatin
1960:
1958:
1955:
1953:
1950:
1949:
1947:
1945:
1941:
1935:
1932:
1930:
1927:
1925:
1922:
1920:
1917:
1915:
1911:
1910:
1906:
1903:
1901:
1897:
1894:
1892:
1888:
1887:
1884:
1881:
1879:
1876:
1874:
1871:
1868:
1864:
1861:
1859:
1856:
1854:
1851:
1849:
1845:
1844:
1841:
1838:
1836:
1835:Prednimustine
1833:
1830:
1826:
1823:
1821:
1818:
1815:
1812:
1810:
1806:
1803:
1801:
1798:
1796:
1793:
1791:
1787:
1786:
1784:
1782:
1778:
1775:
1772:
1767:
1763:
1753:
1750:
1748:
1745:
1743:
1740:
1738:
1735:
1732:
1729:
1727:
1724:
1722:
1718:
1717:
1713:
1710:
1707:
1705:
1702:
1700:
1697:
1695:
1692:
1690:
1687:
1685:
1682:
1679:
1675:
1672:
1670:
1667:
1665:
1661:
1660:
1656:
1655:
1653:
1651:
1650:Intercalation
1647:
1643:
1636:
1633:
1631:
1627:
1626:
1622:
1621:
1619:
1617:
1613:
1606:
1603:
1601:
1598:
1596:
1593:
1591:
1588:
1586:
1583:
1581:
1578:
1576:
1573:
1571:
1568:
1566:
1563:
1561:
1558:
1556:
1552:
1551:
1547:
1546:
1544:
1542:
1538:
1535:
1532:
1527:
1523:
1512:
1508:
1507:
1503:
1502:
1500:
1498:
1494:
1487:
1484:
1482:
1478:
1477:
1473:
1472:
1468:
1464:
1463:
1459:
1458:
1454:
1453:+daunorubicin
1451:
1447:
1446:
1442:
1441:
1437:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1417:Doxifluridine
1415:
1413:
1410:
1408:
1404:
1403:
1399:
1398:
1396:
1394:
1390:
1383:
1380:
1378:
1374:
1373:
1369:
1367:
1366:Rabacfosadine
1364:
1362:
1359:
1356:
1353:
1351:
1348:
1346:
1342:
1341:
1337:
1333:
1332:
1328:
1324:
1323:
1319:
1318:
1316:
1314:
1310:
1303:
1300:
1298:
1294:
1293:
1289:
1286:
1283:
1281:
1278:
1276:
1273:
1271:
1267:
1266:
1262:
1261:
1259:
1257:
1253:
1250:
1247:
1242:
1236:
1233:
1229:
1225:
1214:
1210:
1209:
1205:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1179:
1177:
1173:
1172:
1168:
1167:
1165:
1161:
1154:
1151:
1149:
1146:
1144:
1141:
1139:
1136:
1134:
1130:
1129:
1125:
1124:
1122:
1119:
1114:
1111:
1108:
1103:
1099:
1095:
1090:
1086:
1082:
1074:
1069:
1067:
1062:
1060:
1055:
1054:
1051:
1045:
1041:
1038:
1037:
1024:
1020:
1016:
1012:
1008:
1004:
997:
989:
987:9780471960300
983:
979:
972:
964:
960:
955:
950:
945:
940:
937:: 1849–1854.
936:
932:
928:
921:
913:
909:
905:
901:
897:
893:
889:
882:
874:
870:
865:
860:
856:
852:
848:
844:
840:
833:
825:
821:
817:
813:
809:
805:
801:
797:
790:
782:
778:
772:
764:
757:
749:
742:
735:
731:
728:
724:
720:
717:
711:
703:
699:
695:
691:
686:
681:
677:
673:
669:
665:
658:
656:
647:
641:
639:
637:
629:
625:
620:
612:
608:
604:
600:
596:
592:
585:
577:
571:
567:
560:
556:
546:
543:
542:
536:
534:
526:
522:
519:
516:
512:
508:
504:
500:
497:
494:
490:
486:
482:
479:
473:
469:
465:
461:
460:
458:
454:
450:
446:
443:
439:
435:
431:
427:
426:
424:
420:
416:
412:
409:
408:
406:
405:nucleic acids
402:
398:
394:
391:
390:
389:
381:
379:
375:
371:
366:
364:
360:
356:
351:
349:
345:
341:
329:
326:
324:
321:
319:
316:
314:
311:
309:
308:Actinomycin-D
306:
305:
304:
299:
296:
294:
291:
289:(Adriamycin®)
288:
285:
283:
280:
279:
278:
275:
273:
268:
266:
262:
261:dihydrofolate
258:
257:sulfanilamide
254:
244:
242:
238:
237:nucleic acids
234:
230:
225:
223:
219:
215:
211:
207:
203:
199:
195:
191:
184:
181:
178:
175:
173:
170:
168:
165:
162:
159:
157:
154:
152:
149:
146:
143:
140:
137:
134:
130:
127:
123:
122:
121:
118:
114:
112:
108:
93:
91:
87:
86:cell division
83:
79:
75:
71:
67:
63:
59:
56:the use of a
55:
51:
43:
39:
34:
30:
19:
2679:Tazemetostat
2643:Alitretinoin
2636:
2547:Estramustine
2527:Elsamitrucin
2517:Eflornithine
2471:Pegaspargase
2467:Asparaginase
2460:
2429:Testolactone
2422:
2410:
2398:
2352:
2337:Panobinostat
2320:
2290:
2278:
2266:
2254:
2225:
2190:
2178:
2131:
2127:Padeliporfin
2066:Dactinomycin
2062:Streptomyces
2043:Temozolomide
2038:Mitozolomide
2026:
2017:Mitobronitol
2006:Procarbazine
1999:
1987:Nonclassical
1912:
1889:
1883:Streptozocin
1848:Nitrosoureas
1846:
1820:Chlorambucil
1814:Trofosfamide
1800:Chlormethine
1795:Bendamustine
1788:
1726:Mitoxantrone
1721:Losoxantrone
1714:
1674:Daunorubicin
1657:
1623:
1560:Camptothecin
1548:
1504:
1474:
1460:
1443:
1427:Fluorouracil
1407:Capecitabine
1400:
1370:
1334:
1320:
1290:
1285:Pralatrexate
1275:Methotrexate
1263:
1240:
1206:
1169:
1126:
1006:
1002:
996:
977:
971:
934:
930:
920:
895:
891:
881:
846:
842:
832:
799:
795:
789:
780:
771:
762:
756:
747:
741:
710:
667:
663:
619:
594:
590:
584:
565:
559:
545:Antinutrient
530:
507:nucleic acid
489:nucleic acid
430:Azathioprine
387:
367:
352:
337:
328:Phototrexate
323:Mitoxantrone
302:
282:Daunorubicin
276:
269:
250:
226:
194:azathioprine
187:
183:Phototrexate
172:Methotrexate
139:Capecitabine
126:Fluorouracil
119:
115:
104:
92:for cancer.
90:chemotherapy
49:
47:
38:methotrexate
29:
2754:from market
2724:Vorasidenib
2704:Trabectedin
2689:Tiazofurine
2684:Tebentafusp
2669:Tagraxofusp
2627:Plitidepsin
2597:Mitoguazone
2537:Epacadostat
2507:Demecolcine
2451:Aflibercept
2424:Sex steroid
2297:Fuzuloparib
2238:Carfilzomib
2210:Palbociclib
2200:Abemaciclib
2153:Verteporfin
2117:Efaproxiral
2033:Dacarbazine
1995:Altretamine
1977:Satraplatin
1972:Oxaliplatin
1952:Carboplatin
1929:Triaziquone
1900:Mannosulfan
1878:Ranimustine
1858:Fotemustine
1699:Pirarubicin
1684:Doxorubicin
1678:+cytarabine
1664:Aclarubicin
1625:Podophyllum
1550:Camptotheca
1481:Azacitidine
1467:Gemcitabine
1422:Floxuridine
1355:Fludarabine
1350:Clofarabine
1336:Halogenated
1327:Pentostatin
1302:Raltitrexed
1270:Aminopterin
1213:Ixabepilone
1208:Epothilones
1176:Cabazitaxel
1153:Vinorelbine
1138:Vincristine
1133:Vinblastine
1118:microtubule
898:(2): P205.
796:ChemBioChem
685:2445/126377
521:antifolates
503:nucleotides
468:Gemcitabine
449:pyrimidines
438:Fludarabine
434:Thiopurines
401:nucleobases
397:nucleobases
370:mitomycin C
340:mitomycin C
318:Mitomycin-C
287:Doxorubicin
253:antibiotics
247:Antibiotics
229:cytostatics
161:Gemcitabine
156:Fludarabine
151:Floxuridine
82:cell growth
66:antifolates
2785:Categories
2719:Verdinexor
2714:Venetoclax
2617:Oblimersen
2612:Navitoclax
2587:Lucanthone
2582:Lonidamine
2572:Lifileucel
2567:Ivosidenib
2562:Imetelstat
2532:Enasidenib
2522:Elesclomol
2487:Bexarotene
2482:Belzutifan
2417:Bexarotene
2405:Atrasentan
2380:Umbralisib
2375:Idelalisib
2365:Copanlisib
2347:Vorinostat
2342:Romidepsin
2332:Entinostat
2327:Belinostat
2285:Masoprocol
2273:Tiazofurin
2261:Anagrelide
2233:Bortezomib
2220:Seliciclib
2215:Ribociclib
2195:inhibitors
2185:Tipifarnib
2148:Temoporfin
2143:Talaporfin
2081:Plicamycin
2076:Mitomycins
2022:Pipobroman
2001:Hydrazines
1967:Nedaplatin
1919:Carboquone
1914:Aziridines
1905:Treosulfan
1853:Carmustine
1840:Uramustine
1809:Ifosfamide
1781:Alkylating
1742:Bisantrene
1731:Pixantrone
1704:Valrubicin
1694:Idarubicin
1689:Epirubicin
1635:Teniposide
1590:Lurtotecan
1585:Irinotecan
1486:Decitabine
1450:Cytarabine
1393:Pyrimidine
1382:Tioguanine
1372:Thiopurine
1361:Nelarabine
1345:Cladribine
1297:Pemetrexed
1280:Pemetrexed
1256:Folic acid
1196:Paclitaxel
1148:Vinflunine
551:References
525:folic acid
515:phosphates
513:, and 1–3
485:nucleoside
472:Cytarabine
462:Examples:
428:Examples:
372:(MMC) and
334:Other uses
298:Idarubicin
293:Epirubicin
272:cell cycle
255:, such as
210:cell cycle
202:pyrimidine
177:Pemetrexed
145:Cytarabine
70:folic acid
62:metabolism
58:metabolite
42:folic acid
2764:Phase III
2752:Withdrawn
2729:Vosaroxin
2709:Veliparib
2664:Sotorasib
2654:Selinexor
2648:Tretinoin
2638:Retinoids
2552:Glasdegib
2497:Celecoxib
2446:Adagrasib
2370:Duvelisib
2360:Alpelisib
2315:Rucaparib
2302:Niraparib
2243:Oprozomib
2205:Alvocidib
2071:Bleomycin
2028:Triazenes
2012:Etoglucid
1957:Cisplatin
1873:Nimustine
1867:Semustine
1863:Lomustine
1825:Melphalan
1752:Menogaril
1747:Crisnatol
1737:Amsacrine
1709:Zorubicin
1669:Amrubicin
1630:Etoposide
1605:Topotecan
1600:Silatecan
1595:Rubitecan
1580:Gimatecan
1565:Cositecan
1555:Belotecan
1231:inhibitor
1201:Tesetaxel
1191:Ortataxel
1186:Larotaxel
1181:Docetaxel
1143:Vindesine
423:guanosine
419:adenosine
395:(altered
378:pterygium
313:Bleomycin
241:apoptosis
214:thymidine
179:(Alimta®)
163:(Gemzar®)
141:(Xeloda®)
36:The drug
2602:Mitotane
2542:Eribulin
2310:Olaparib
2248:Ixazomib
1924:Thiotepa
1896:Busulfan
1575:Exatecan
1412:Carmofur
1120:assembly
1083: /
1040:Overview
1023:11836090
963:23152665
912:72098513
873:15205228
824:58567138
816:30656808
730:Archived
719:Archived
702:53043366
694:30346152
611:11008002
539:See also
453:cytosine
355:fibrosis
348:glaucoma
208:(of the
147:(Ara-C®)
96:Function
72:; thus,
54:inhibits
1531:S phase
1432:Tegafur
1246:S phase
1171:Taxanes
1107:M phase
954:3497463
864:1772249
457:thymine
415:purines
233:enzymes
206:S phase
200:) or a
2747:WHO-EM
2356:(Pi3K)
1313:Purine
1116:Block
1021:
984:
961:
951:
910:
871:
861:
822:
814:
700:
692:
630:(MeSH)
609:
572:
470:, and
436:, and
218:uracil
190:purine
135:(6-MP)
128:(5-FU)
2268:IMPDI
2163:Other
908:S2CID
820:S2CID
698:S2CID
511:sugar
493:sugar
384:Types
78:toxic
44:(top)
2354:PIKI
2322:HDAC
1771:CCNS
1019:PMID
982:ISBN
959:PMID
869:PMID
812:PMID
690:PMID
607:PMID
570:ISBN
509:, a
455:and
421:and
84:and
2400:ERA
2256:PhI
2227:PrI
2192:CDK
2104:PDT
1102:MIs
1098:SPs
1089:L01
1042:at
1011:doi
949:PMC
939:doi
900:doi
896:129
859:PMC
851:doi
804:doi
680:hdl
672:doi
668:140
599:doi
403:in
48:An
2787::
2760::
2280:LI
2180:FI
1646:II
1616:II
1438:))
1017:.
1007:10
1005:.
957:.
947:.
933:.
929:.
906:.
894:.
890:.
867:.
857:.
847:88
845:.
841:.
818:.
810:.
800:20
798:.
779:.
696:.
688:.
678:.
666:.
654:^
635:^
605:.
595:87
593:.
501:–
483:–
466:,
459:.
432:,
425:.
380:.
350:.
274:.
196:,
131:6-
124:5-
2650:)
2641:(
2473:)
2469:/
2465:(
2431:)
2427:(
2419:)
2415:(
2407:)
2403:(
2382:)
2358:(
2349:)
2325:(
2317:)
2295:(
2287:)
2283:(
2275:)
2271:(
2263:)
2259:(
2222:)
2198:(
2187:)
2183:(
2155:)
2136:(
2102:/
2083:)
2064:(
2045:)
2031:(
2008:)
2004:(
1916::
1907:)
1898:(
1893::
1869:)
1865:(
1850::
1831:)
1827:(
1816:)
1807:(
1792::
1773:)
1769:(
1733:)
1719:(
1711:)
1680:)
1676:(
1662:(
1648:+
1637:)
1628:(
1607:)
1553:(
1541:I
1533:)
1529:(
1513:)
1509:(
1488:)
1479:(
1469:)
1465:(
1455:)
1448:(
1434:(
1405:(
1384:)
1375:(
1357:)
1343:(
1338:/
1329:)
1325:(
1304:)
1295:(
1287:)
1268:(
1248:)
1244:(
1215:)
1211:(
1203:)
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192:(
20:)
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