652:
indomethacin (5 mg/kg) . Hyperforin turned out to be a novel type of 5-lipoxygenase inhibitor with high effectivity in vivo and suppressed oxidative bursts in polymorphonuclear cells at 1.8 μmol/L in vitro . Inhibition of IFN-γ production, strong downregulation of CXCR3 expression on activated T cells, and downregulation of matrix metalloproteinase 9 expression caused
Cabrelle et al. to test the effectivity of hyperforin in a rat model of experimental allergic encephalomyelitis (EAE). Hyperforin attenuated the symptoms significantly, and the authors discussed hyperforin as a putative therapeutic molecule for the treatment of autoimmune inflammatory diseases sustained by Th1 cells.
503:
effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Sulfido-peptide leukotrienes (LTC4, LTD4, LTE4, also known as the slow-releasing substances of anaphylaxis) and LTB4, a chemoattractant for neutrophils and eosinophils, can be measured in a number of biological fluids including bronchoalveolar lavage fluid (BALF) from asthmatic patients.
602:
cyclooxygenase-1 and 5-lipoxygenase . Moreover, this species attenuated the expression of iNOS in periodontal tissue, which may contribute to the attenuation of the formation of nitrotyrosine, an indication of nitrosative stress . In this context, a combination of several active constituents of
Hypericum species is the carrier of their anti-inflammatory activity.
601:
These researches are according to an investigation of the effect of H. perforatum on the NF-κB inflammation factor, conducted by Bork et al. (1999), in which hyperforin provided a potent inhibition of TNFα-induced activation of NF-κB . Another important activity for hyperforin is a dual inhibitor of
651:
Anti-inflammatory mechanisms of hyperforin have been described as inhibition of cyclooxygenase-1 (but not COX-2) and 5-lipoxygenase at low concentrations of 0.3 μmol/L and 1.2 μmol/L, respectively , and of PGE2 production in vitro and in vivo with superior efficiency (ED50 = 1 mg/kg) compared to
502:
Zileuton is a specific inhibitor of 5-lipoxygenase and thus inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. Leukotrienes are substances that induce numerous biological
742:
Jawien, J.; Gajda, M.; Rudling, M.; Mateuszuk, L.; Olszanecki, R.; Guzik, T. J.; Cichocki, T.; Chlopicki, S.; Korbut, R. (March 2006). "Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice".
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2402:
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870:
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2392:
2316:
382:
Singh, Rakesh Kumar; Tandon, Ruchi; Dastidar, Sunanda Ghosh; Ray, Abhijit (2013). "A review on leukotrienes and their receptors with reference to asthma".
1507:
863:
1883:
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1720:
559:
de Melo MS, Quintans Jde S, Araújo AA, Duarte MC, Bonjardim LR, Nogueira PC, Moraes VR, de Araújo-Júnior JX, Ribeiro EA, Quintans-Júnior LJ (2014).
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These modifiers have been shown to improve asthma symptoms, reduce asthma exacerbations and limit markers of inflammation such as
914:
1586:
1371:
990:
888:
450:
220:
255:
Some chemicals found in trace amounts in food, and some dietary supplements, also have been shown to inhibit 5-LOX, such as
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80:
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Antileukotrienes such as montelukast may be used in patients with asthma associated with allergic rhinitis.
138:) and consequently opposes the function of these inflammatory mediators; leukotrienes are produced by the
2235:
127:
347:
Scott JP, Peters-Golden M (September 2013). "Antileukotriene agents for the treatment of lung disease".
1154:
880:
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1839:
1696:
433:
Al-Ahmad, Mona; Hassab, Mohammed; Al Ansari, Ali (2020-12-21). "Allergic and Non-allergic
Rhinitis".
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1487:
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842:
838:
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561:"A systematic review for anti-inflammatory property of Clusiaceae family: a preclinical approach"
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8:
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797:"5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy"
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166:. Leukotriene receptor antagonists are sometimes colloquially referred to as
139:
878:
229:
will inhibit the synthetic pathway of leukotriene metabolism; drugs such as
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fluid. This demonstrates that they have anti-inflammatory properties.
237:(FLAP) inhibit functioning of 5-lipoxygenase and may help in treating
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2397:
2288:
2253:
1456:
1446:
1421:
1084:
961:
936:
256:
200:
16:
Medication class that inhibits leukotriene synthesis and/or activity.
211:
There are two main approaches to block the actions of leukotrienes.
195:, can be used to treat these diseases. They are less effective than
2624:
2588:
2502:
2435:
2326:
2283:
1990:
1779:
1379:
1270:
905:
264:
249:
186:
41:
2561:
2364:
2218:
1567:
1092:
884:
621:"Topical application of St. John's wort (Hypericum perforatum)"
558:
292:
230:
159:
1562:
1096:
554:
552:
550:
437:. Cham: Springer International Publishing. pp. 241–252.
199:
for treating asthma, but more effective for treating certain
155:
76:
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214:
163:
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508:
2179:
2116:
1943:
614:
612:
610:
432:
2340:
1929:
618:
381:
46:
Leukotriene modifier; Leukotriene receptor antagonist
2513:
2413:
2375:
1650:
794:
607:
492:. Cornerstone Therapeutics Inc. June 2012. p. 1
279:
Antagonism of cysteinyl-leukotriene type 1 receptors
244:
Examples of 5-LOX inhibitors include drugs, such as
2236:
1508:
Fluticasone furoate/umeclidinium bromide/vilanterol
619:Wölfle U, Seelinger G, Schempp CM (February 2014).
291:block the actions of cysteinyl leukotrienes at the
699:Frieri M (2015). "Mast Cell Activation Syndrome".
346:
1840:
1697:
342:
340:
338:
2718:
2604:
2572:
2451:
477:
475:
473:
2540:
1683:
1493:Beclometasone/formoterol/glycopyrronium bromide
790:
788:
786:
784:
782:
692:
795:Bishayee K, Khuda-Bukhsh AR (September 2013).
375:
335:
1636:
1533:Indacaterol/glycopyrronium bromide/mometasone
864:
470:
1503:Budesonide/glycopyrronium bromide/formoterol
779:
295:receptor on target cells such as bronchial
2673:5-HPETE (arachidonic acid 5-hydroperoxide)
1643:
1629:
871:
857:
745:European Journal of Clinical Investigation
735:
535:. 3.6. University of Alberta. 30 June 2013
490:United States Food and Drug Administration
173:Leukotriene receptor antagonists, such as
841:at the U.S. National Library of Medicine
812:
636:
586:
576:
2187:Tooltip Cysteinyl leukotriene receptor E
2124:Tooltip Cysteinyl leukotriene receptor 2
1951:Tooltip Cysteinyl leukotriene receptor 1
663:
215:Inhibition of the 5-lipoxygenase pathway
118:, is a medication which functions as a
2719:
1934:Tooltip Cysteinyl leukotriene receptor
1372:Arachidonate 5-lipoxygenase inhibitors
801:Acta Biochim. Biophys. Sin. (Shanghai)
698:
185:, and 5-lipoxygenase inhibitors, like
1624:
852:
657:
221:Arachidonate 5-lipoxygenase inhibitor
2522:Tooltip Leukotriene B4 ω-hydroxylase
2418:Tooltip Arachidonate 15-lipoxygenase
2380:Tooltip Arachidonate 12-lipoxygenase
1568:Theophylline/ephedrine/phenobarbital
2241:Tooltip Arachidonate 5-lipoxygenase
435:Textbook of Clinical Otolaryngology
310:counts in the peripheral blood and
13:
1563:Theophylline/ephedrine/hydroxyzine
1528:Indacaterol/glycopyrronium bromide
565:Evid Based Complement Alternat Med
14:
2738:
2653:γ-Linolenic acid (gamolenic acid)
2307:Meclofenamic acid (meclofenamate)
1848:Tooltip Leukotriene B4 receptor 2
1705:Tooltip Leukotriene B4 receptor 1
1553:Salbutamol (albuterol)/budesonide
1523:Glycopyrronium bromide/formoterol
1518:Fluticasone propionate/salmeterol
832:
664:Fanta CH (March 2009). "Asthma".
235:5-lipoxygenase activating protein
2612:Tooltip Leukotriene D4 hydrolase
2581:Tooltip Leukotriene C4 hydrolase
2460:Tooltip Leukotriene A4 hydrolase
1390:Thromboxane receptor antagonists
757:10.1111/j.1365-2362.2006.01606.x
2705:Prostanoid signaling modulators
2549:Tooltip Leukotriene C4 synthase
1688:Tooltip Leukotriene B4 receptor
1573:Umeclidinium bromide/vilanterol
136:cysteinyl leukotriene receptors
116:leukotriene receptor antagonist
1543:Ipratropium bromide/salbutamol
1513:Fluticasone furoate/vilanterol
1128:Orciprenaline (metaproterenol)
225:Drugs that inhibit the enzyme
1:
2698:Receptor/signaling modulators
1483:Aclidinium bromide/formoterol
971:Levosalbutamol (levalbuterol)
349:Am. J. Respir. Crit. Care Med
329:
206:
85: • Receptors:
1118:Isoprenaline (isoproterenol)
443:10.1007/978-3-030-54088-3_22
396:10.3109/02770903.2013.823447
7:
1093:+theophylline/phenobarbital
881:obstructive airway diseases
317:
128:arachidonate 5-lipoxygenase
75: • Enzymes:
10:
2743:
483:"Zyflo (Zileuton tablets)"
361:10.1164/rccm.201301-0023PP
218:
152:microvascular permeability
2689:
2637:
2602:
2570:
2538:
2511:
2449:
2411:
2373:
2234:
2217:
2177:
2114:
1941:
1927:
1838:
1695:
1681:
1664:
1581:
1475:
1439:
1411:
1388:
1370:
1342:
1332:
1269:
1246:
1198:
1145:
1077:
1035:
989:
913:
900:
713:10.1007/s12016-015-8487-6
533:Human Metabolome Database
97:
92:
68:
50:
40:
35:
26:
21:
1488:Beclometasone/formoterol
1097:theophylline/hydroxyzine
1037:Ultra-long-acting β
843:Medical Subject Headings
701:Clin Rev Allergy Immunol
528:Hyperforin (HMDB0030463)
2727:Leukotriene antagonists
2658:Dihomo-γ-linolenic acid
1344:Leukotriene antagonists
839:Leukotriene+antagonists
1558:Theophylline/ephedrine
1538:Indacaterol/mometasone
1299:Choline theophyllinate
1218:Glycopyrronium bromide
1180:Fluticasone propionate
967:Salbutamol (albuterol)
638:10.1055/s-0033-1351019
312:bronchoalveolar lavage
2594:Serine-borate complex
1760:CGS-23131 (LY-223982)
1548:Mometasone/formoterol
1498:Budesonide/formoterol
1248:Mast cell stabilizers
1205:muscarinic antagonist
678:10.1056/NEJMra0804579
142:and serve to promote
2530:17-Octadecynoic acid
2300:Hypericum perforatum
1476:Combination products
1238:Umeclidinium bromide
246:meclofenamate sodium
192:Hypericum perforatum
112:leukotriene modifier
2625:Ubenimex (bestatin)
2503:Ubenimex (bestatin)
1223:Ipratropium bromide
915:Short-acting β
814:10.1093/abbs/gmt064
578:10.1155/2014/960258
301:receptor antagonism
144:bronchoconstriction
132:receptor antagonist
63:Receptor antagonism
52:Mechanism of action
2393:3-Methoxytropolone
2317:N-Stearoyldopamine
1608:Never to phase III
1233:Tiotropium bromide
1228:Oxitropium bromide
1213:Aclidinium bromide
991:Long-acting β
61: •
56: •
2714:
2713:
2633:
2632:
2302:(St. John's Wort)
2228:
2213:
2212:
2209:
2208:
1923:
1922:
1675:
1618:
1617:
1435:
1434:
1141:
1140:
452:978-3-030-54087-6
384:Journal of Asthma
130:) or leukotriene
104:
103:
70:Biological target
58:Enzyme inhibition
36:Class identifiers
2734:
2668:Arachidonic acid
2613:
2609:
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2523:
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1200:Anticholinergics
911:
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124:enzyme inhibitor
110:, also known as
83:
22:Antileukotrienes
19:
18:
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2407:
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2221:
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2186:
2183:
2173:
2154:
2146:
2138:
2123:
2120:
2110:
1981:
1973:
1965:
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1933:
1919:
1895:
1887:
1847:
1844:
1834:
1750:
1732:
1724:
1704:
1701:
1687:
1668:
1660:
1649:
1619:
1614:
1613:
1598:Clinical trials
1577:
1471:
1431:
1414:PDE4 inhibitors
1407:
1384:
1366:
1328:
1265:
1242:
1203:
1194:
1147:Glucocorticoids
1137:
1123:Methylephedrine
1073:
1040:
1031:
994:
985:
918:
896:
877:
835:
830:
793:
780:
740:
736:
697:
693:
672:(10): 1002–14.
662:
658:
631:(2–3): 109–20.
617:
608:
557:
548:
538:
536:
521:
520:
509:
495:
493:
485:
481:
480:
471:
453:
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380:
376:
345:
336:
332:
320:
283:Agents such as
281:
239:atherosclerosis
233:that block the
223:
217:
209:
197:corticosteroids
108:antileukotriene
84:
74:
60:
17:
12:
11:
5:
2740:
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2663:Diacylglycerol
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2013:
2008:
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1884:20-Hydroxy-LTB
1881:
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1787:
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1757:
1752:
1748:
1747:20-Carboxy-LTB
1740:
1739:
1734:
1730:
1726:
1722:
1721:20-Hydroxy-LTB
1718:
1709:
1707:
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1676:
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1473:
1472:
1470:
1469:
1464:
1459:
1454:
1449:
1443:
1441:
1440:Others/unknown
1437:
1436:
1433:
1432:
1430:
1429:
1424:
1418:
1416:
1409:
1408:
1406:
1405:
1400:
1394:
1392:
1386:
1385:
1383:
1382:
1376:
1374:
1368:
1367:
1365:
1364:
1359:
1354:
1348:
1346:
1337:
1330:
1329:
1327:
1326:
1321:
1316:
1311:
1306:
1301:
1296:
1291:
1286:
1281:
1275:
1273:
1267:
1266:
1264:
1263:
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1252:
1250:
1244:
1243:
1241:
1240:
1235:
1230:
1225:
1220:
1215:
1209:
1207:
1196:
1195:
1193:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1151:
1149:
1143:
1142:
1139:
1138:
1136:
1135:
1130:
1125:
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1115:
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1081:
1079:
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1072:
1071:
1066:
1061:
1056:
1051:
1045:
1043:
1038:
1033:
1032:
1030:
1029:
1024:
1019:
1010:
1005:
999:
997:
992:
987:
986:
984:
983:
978:
973:
964:
959:
954:
949:
944:
939:
934:
929:
923:
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916:
908:
898:
897:
876:
875:
868:
861:
853:
847:
846:
834:
833:External links
831:
829:
828:
807:(9): 709–719.
778:
751:(3): 141–146.
734:
707:(3): 353–365.
691:
656:
606:
546:
507:
469:
451:
425:
390:(9): 922–931.
374:
355:(5): 538–544.
333:
331:
328:
327:
326:
319:
316:
280:
277:
273:St John's wort
227:5-lipoxygenase
219:Main article:
216:
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208:
205:
102:
101:
95:
94:
90:
89:
72:
66:
65:
54:
48:
47:
44:
38:
37:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
2739:
2728:
2725:
2724:
2722:
2707:
2706:
2702:
2700:
2699:
2695:
2692:
2691:
2688:
2682:
2678:Leukotriene A
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2648:Linoleic acid
2646:
2643:
2642:
2640:
2636:
2626:
2623:
2621:
2618:
2617:
2615:
2610:
2601:
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2437:
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2416:
2410:
2404:
2401:
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2282:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2246:
2244:
2239:
2233:
2230:
2226:
2220:
2216:
2202:
2198:Leukotriene E
2196:
2193:
2192:
2190:
2185:
2176:
2170:
2167:
2165:
2162:
2159:
2158:
2155:
2151:Leukotriene E
2149:
2147:
2143:Leukotriene D
2141:
2139:
2135:Leukotriene C
2133:
2130:
2129:
2127:
2122:
2113:
2107:
2104:
2102:
2099:
2097:
2094:
2092:
2089:
2087:
2084:
2082:
2079:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2057:
2054:
2052:
2049:
2047:
2044:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2017:
2014:
2012:
2009:
2007:
2004:
2002:
1999:
1997:
1994:
1992:
1989:
1986:
1985:
1982:
1978:Leukotriene E
1976:
1974:
1970:Leukotriene D
1968:
1966:
1962:Leukotriene C
1960:
1957:
1956:
1954:
1949:
1940:
1937:
1932:
1926:
1916:
1913:
1911:
1908:
1906:
1903:
1900:
1899:
1896:
1892:Leukotriene B
1890:
1888:
1882:
1880:
1877:
1875:
1872:
1870:
1867:
1865:
1862:
1860:
1857:
1854:
1853:
1851:
1846:
1837:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1803:
1801:
1798:
1796:
1793:
1791:
1788:
1786:
1783:
1781:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1745:
1742:
1741:
1738:
1735:
1733:
1729:Leukotriene B
1727:
1725:
1719:
1717:
1714:
1711:
1710:
1708:
1703:
1694:
1691:
1686:
1680:
1677:
1673:
1667:
1663:
1659:
1656:
1653:
1646:
1641:
1639:
1634:
1632:
1627:
1626:
1623:
1607:
1605:
1602:
1601:
1599:
1596:
1593:
1590:
1588:
1585:
1584:
1580:
1574:
1571:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1534:
1531:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1509:
1506:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1480:
1478:
1474:
1468:
1465:
1463:
1460:
1458:
1455:
1453:
1450:
1448:
1445:
1444:
1442:
1438:
1428:
1425:
1423:
1420:
1419:
1417:
1415:
1412:Non-xanthine
1410:
1404:
1401:
1399:
1396:
1395:
1393:
1391:
1387:
1381:
1378:
1377:
1375:
1373:
1369:
1363:
1360:
1358:
1355:
1353:
1350:
1349:
1347:
1345:
1341:
1338:
1335:
1331:
1325:
1322:
1320:
1319:Proxyphylline
1317:
1315:
1314:Etamiphylline
1312:
1310:
1307:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1289:Aminophylline
1287:
1285:
1282:
1280:
1277:
1276:
1274:
1272:
1268:
1262:
1259:
1257:
1254:
1253:
1251:
1249:
1245:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1219:
1216:
1214:
1211:
1210:
1208:
1206:
1201:
1197:
1191:
1190:Triamcinolone
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1160:Betamethasone
1158:
1156:
1155:Beclometasone
1153:
1152:
1150:
1148:
1144:
1134:
1131:
1129:
1126:
1124:
1121:
1119:
1116:
1114:
1113:Hexoprenaline
1111:
1109:
1106:
1104:
1101:
1098:
1094:
1090:
1089:+theophylline
1086:
1083:
1082:
1080:
1076:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1046:
1044:
1042:
1034:
1028:
1025:
1023:
1020:
1018:
1014:
1011:
1009:
1006:
1004:
1001:
1000:
998:
996:
988:
982:
979:
977:
974:
972:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
924:
922:
920:
912:
909:
907:
903:
899:
894:
890:
886:
882:
874:
869:
867:
862:
860:
855:
854:
851:
844:
840:
837:
836:
824:
820:
815:
810:
806:
802:
798:
791:
789:
787:
785:
783:
774:
770:
766:
762:
758:
754:
750:
746:
738:
730:
726:
722:
718:
714:
710:
706:
702:
695:
687:
683:
679:
675:
671:
667:
660:
653:
648:
644:
639:
634:
630:
626:
622:
615:
613:
611:
603:
598:
594:
589:
584:
579:
574:
570:
566:
562:
555:
553:
551:
534:
530:
527:
524:
518:
516:
514:
512:
504:
491:
484:
478:
476:
474:
466:
462:
458:
454:
448:
444:
440:
436:
429:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
378:
370:
366:
362:
358:
354:
350:
343:
341:
339:
334:
325:
324:Antihistamine
322:
321:
315:
313:
309:
304:
302:
298:
297:smooth muscle
294:
290:
286:
276:
274:
270:
266:
262:
258:
253:
251:
247:
242:
240:
236:
232:
228:
222:
212:
204:
202:
198:
194:
193:
188:
184:
180:
176:
171:
169:
165:
161:
158:secretion in
157:
153:
149:
145:
141:
140:immune system
137:
133:
129:
125:
121:
117:
113:
109:
100:
96:
91:
88:
82:
78:
73:
71:
67:
64:
59:
55:
53:
49:
45:
43:
39:
34:
31:
30:
25:
20:
2703:
2696:
2644:
2488:JNJ-26993135
2483:Fosinoprilat
2333:
2299:
2269:Caffeic acid
2194:
2161:Antagonists:
2160:
2131:
1988:Antagonists:
1987:
1958:
1902:Antagonists:
1901:
1855:
1744:Antagonists:
1743:
1712:
1452:Ensifentrine
1324:Theophylline
1309:Enprofylline
1284:Ambuphylline
1256:Cromoglicate
1133:Racephedrine
1017:Arformoterol
804:
800:
748:
744:
737:
704:
700:
694:
669:
666:N Engl J Med
665:
659:
650:
628:
624:
600:
568:
564:
537:. Retrieved
532:
529:
526:
501:
494:. Retrieved
489:
464:
434:
428:
387:
383:
377:
352:
348:
305:
282:
261:caffeic acid
254:
243:
224:
210:
190:
172:
167:
148:inflammation
115:
111:
107:
105:
93:Legal status
27:
2645:Precursors:
2468:Acebilustat
2342:inhibitors:
2312:Minocycline
2101:Zafirlukast
2046:Montelukast
1652:Leukotriene
1594:from market
1427:Roflumilast
1403:Seratrodast
1362:Zafirlukast
1352:Montelukast
1304:Doxofylline
1294:Bamifylline
1175:Flunisolide
1170:Ciclesonide
1103:Epinephrine
1059:Indacaterol
1008:Clenbuterol
981:Tulobuterol
976:Terbutaline
902:Adrenergics
539:12 December
496:12 December
289:zafirlukast
285:montelukast
203:disorders.
179:zafirlukast
175:montelukast
120:leukotriene
99:In Wikidata
2620:Cilastatin
2557:Azelastine
2322:Timegadine
2294:Hyperforin
2225:inhibitors
2091:Tomelukast
2086:Tipelukast
2071:SKF-104353
2066:Ritolukast
2061:Pranlukast
2056:Pobilukast
2036:Masilukast
2021:ICI-198615
2011:Cinalukast
1820:Ticolubant
1790:Moxilubant
1765:CGS-25019C
1658:modulators
1467:Omalizumab
1462:Fenspiride
1398:Ramatroban
1357:Pranlukast
1336:inhibition
1334:Eicosanoid
1279:Acefylline
1261:Nedocromil
1185:Mometasone
1165:Budesonide
1108:Etafedrine
1069:Vilanterol
1064:Olodaterol
1054:Carmoterol
1049:Abediterol
1027:Salmefamol
1022:Salmeterol
1013:Formoterol
1003:Bambuterol
957:Reproterol
952:Procaterol
947:Pirbuterol
942:Isoetarine
932:Carbuterol
927:Bitolterol
879:Drugs for
625:Planta Med
571:: 960258.
330:References
308:eosinophil
269:hyperforin
207:Approaches
183:pranlukast
29:Drug class
2498:SC-57461A
2473:Captopril
2441:PD-146176
2398:Baicalein
2289:Fenleuton
2254:Baicalein
2195:Agonists:
2132:Agonists:
2096:Verlukast
2031:LY-170680
2026:Iralukast
2016:FPL-55712
1959:Agonists:
1915:ZK-158252
1910:LY-255283
1905:CP-195543
1856:Agonists:
1830:ZK-158252
1810:SB-209247
1785:LY-293111
1775:CP-195543
1770:CP-105696
1755:Amelubant
1737:LY-255283
1713:Agonists:
1655:signaling
1604:Phase III
1592:Withdrawn
1457:Eprozinol
1447:Amlexanox
1422:Ibudilast
1271:Xanthines
1085:Ephedrine
962:Rimiterol
937:Fenoterol
906:inhalants
523:"Enzymes"
461:234142758
404:0277-0903
257:baicalein
201:mast cell
122:-related
2721:Category
2693:See also
2589:Acivicin
2436:Luteolin
2355:BAYx1005
2327:Zileuton
2284:Curcumin
2279:CJ-13610
2169:BAYu9916
2164:BAYu9773
2081:Sulukast
2051:ONO-1078
2006:BAYx7195
2001:BAYu9916
1996:BAYu9773
1991:Ablukast
1879:15-HpETE
1869:12-HpETE
1815:SC-53228
1805:RP-69698
1800:RG-14893
1795:ONO-4057
1780:Etalocib
1666:Receptor
1380:Zileuton
1041:agonists
995:agonists
919:agonists
823:23752617
773:44897529
765:16506957
721:25944644
686:19264689
647:24214835
597:24976853
420:11433313
412:23859232
369:23822826
318:See also
265:curcumin
250:zileuton
187:zileuton
168:leukasts
42:Synonyms
2493:SA-6541
2264:BW-B70C
2106:ZD-3523
2076:SR-2640
1874:15-HETE
1859:12-HETE
1825:U-75302
1716:12-HETE
1672:ligands
729:5723622
588:4058220
87:CysLTRs
2638:Others
2562:MK-886
2478:DG-051
2426:2-TEDC
2414:15-LOX
2388:2-TEDC
2376:12-LOX
2365:MK-886
2360:MK-591
2350:AM-679
2345:AM-103
2259:BW-A4C
2249:2-TEDC
2219:Enzyme
2041:MK-571
1864:12-HHT
1587:WHO-EM
885:asthma
845:(MeSH)
821:
771:
763:
727:
719:
684:
645:
595:
585:
459:
449:
418:
410:
402:
367:
293:CysLT1
231:MK-886
181:, and
160:asthma
154:, and
2237:5-LOX
2180:CysLT
2117:CysLT
1944:CysLT
1930:CysLT
1078:Other
769:S2CID
725:S2CID
486:(PDF)
457:S2CID
416:S2CID
156:mucus
77:5-LOX
2336:FLAP
889:COPD
819:PMID
761:PMID
717:PMID
682:PMID
643:PMID
593:PMID
569:2014
541:2014
498:2014
447:ISBN
408:PMID
400:ISSN
365:PMID
299:via
287:and
271:and
248:and
189:and
164:COPD
162:and
114:and
81:FLAP
2605:LTD
2573:LTC
2541:LTC
2514:LTB
2452:LTA
2431:CDC
2403:CDC
2274:CDC
1841:BLT
1698:BLT
1684:BLT
893:R03
809:doi
753:doi
709:doi
674:doi
670:360
633:doi
583:PMC
573:doi
439:doi
392:doi
357:doi
353:188
106:An
2723::
1600::
1095:,
1091:,
904:,
883::
817:.
805:45
803:.
799:.
781:^
767:.
759:.
749:36
747:.
723:.
715:.
705:54
703:.
680:.
668:.
649:.
641:.
629:80
627:.
623:.
609:^
599:.
591:.
581:.
567:.
563:.
549:^
531:.
525:.
510:^
500:.
488:.
472:^
463:.
455:.
445:.
414:.
406:.
398:.
388:50
386:.
363:.
351:.
337:^
303:.
275:.
267:,
263:,
259:,
252:.
241:.
177:,
170:.
150:,
146:,
79:;
2680:4
2607:4
2577:H
2575:4
2545:S
2543:4
2518:H
2516:4
2456:H
2454:4
2227:)
2223:(
2200:4
2182:E
2153:4
2145:4
2137:4
2119:2
1980:4
1972:4
1964:4
1946:1
1894:4
1886:4
1843:2
1749:4
1731:4
1723:4
1700:1
1674:)
1670:(
1644:e
1637:t
1630:v
1202:/
1099:)
1087:(
1039:2
1015:/
993:2
969:/
917:2
895:)
891:(
887:/
872:e
865:t
858:v
825:.
811::
775:.
755::
731:.
711::
688:.
676::
635::
575::
543:.
441::
422:.
394::
371:.
359::
134:(
126:(
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