777:
754:
1346:
1015:
51:
42:
6084:
1516:
1147:. Reviews of research dating from the 1980s show there is some effect in reducing the number and duration of lesions if aciclovir is applied at an early stage of an outbreak. Research shows effectiveness of topical aciclovir in both the early and late stages of the outbreak as well as improving methodologically and in terms of statistical certainty from previous studies. Aciclovir trials show that this agent has no role in preventing
1414:
1358:
6124:
6112:
3784:
3478:
1477:
administration is necessary if high concentrations are required. When orally administered, peak plasma concentration occurs after 1–2 hours. According to the
Biopharmaceutical Classification System, aciclovir is a Class III drug, i.e., soluble with low intestinal permeability. Aciclovir has a high
1271:
in up to 5% to 10% of patients because of precipitation of aciclovir crystals in the kidney. Aciclovir crystalline nephropathy is more common when aciclovir is given as a rapid infusion and in patients with dehydration and preexisting renal impairment. Adequate hydration, a slower rate of infusion,
1605:
In 2009, acyclovir in combination with hydrocortisone cream, marketed as Xerese, was approved in the United States for the early treatment of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time in adults and children (six
1186:
Aciclovir is excreted in the breast milk, therefore it is recommended that caution should be used in breast-feeding women. It has been shown in limited test studies that the nursing infant is exposed to approximately 0.3 mg/kg/day following oral administration of aciclovir to the mother. If
3684:
1307:: In-vitro replication studies have found a synergistic, dose-dependent antiviral activity against HSV-1 and HSV-2 when given with aciclovir. However, this effect has not been clinically established and more studies need to be done to evaluate the true potential of this synergy.
1113:
and acyclovir act by inhibiting viral DNA replication, but as of 2016 there was little evidence that they are effective against
Epstein–Barr virus, they are expensive, they risk causing resistance to antiviral agents, and (in 1% to 10% of cases) can cause unpleasant
2610:"Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America"
1423:. When the virus was reproducing each well contained different amounts of the antiviral drug aciclovir. By counting the plaques (holes formed by the virus in the layer of cells) the potency of the aciclovir to the virus was calculated.
1175:
have failed to demonstrate birth defects. Studies in rats in which they were given the equivalent to 63 times the standard steady-state humans concentrations of the drug on day 10 of gestation showed head and tail anomalies.
3981:
3840:"The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues"
1550:. Since discovery in mid 1970s, it has been used as an effective drug for the treatment of infections caused by most known species of the herpesvirus family, including herpes simplex and varicella zoster viruses.
1167:
The CDC and others have declared that during severe recurrent or first episodes of genital herpes, aciclovir may be used. For severe HSV infections (especially disseminated HSV), IV aciclovir may also be used.
2188:
Elad S, Zadik Y, Hewson I, Hovan A, Correa ME, Logan R, et al. (August 2010). "A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on
Herpesviridea".
1400:
Resistance to aciclovir is rare in people with healthy immune systems, but is more common (up to 10%) in people with immunodeficiencies on chronic antiviral prophylaxis (transplant recipients, people with
1291:
or itch. When applied to the eye, aciclovir is commonly associated (≥1% of patients) with transient mild stinging. Infrequently (0.1–1% of patients), ophthalmic aciclovir is associated with superficial
1530:
with 1-benzoyloxy-2-chloromethoxyethane. The chlorine group at the 6-position of the heterocyclic ring is more reactive than the chlorine at the 2-position, hence it can be selectively replaced by an
2899:"High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study"
1135:
aciclovir is effective to treat severe medical conditions caused by different species of the herpes virus family, including severe localized infections of herpes virus, severe genital herpes,
3974:
1977:
Even with the highest maternal dosages, the dosage of acyclovir in milk is only about 1% of a typical infant dosage and would not be expected to cause any adverse effects in breastfed infants
1313:: Reports of increased half life of aciclovir, as well as decreased urinary excretion and renal clearance have been shown in studies where probenecid is given simultaneously with aciclovir.
4760:
1405:
due to HIV infection). Mechanisms of resistance in HSV include deficient viral thymidine kinase; and mutations to viral thymidine kinase or DNA polymerase, altering substrate sensitivity.
4723:
1538:. Finally, the remaining chlorine was replaced by the amino group of aciclovir using ammonia in methanol. This synthesis and other methods for preparing the compound have been reviewed.
1329:
has been reported in at least one patient who presented with extreme drowsiness and lethargy 30–60 days after receiving IV aciclovir; symptoms resolved when aciclovir was discontinued.
1584:
1337:
Aciclovir may be quantitated in plasma or serum to monitor for drug accumulation in patients with renal dysfunction or to confirm a diagnosis of poisoning in acute overdose victims.
348:
3967:
2532:"5th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice - biomedical prevention"
3476:, Schaeffer HJ, "Methods and compositions for treating viral infections and guanine acyclic nucleosides", published 1980-04-22, assigned to Burroughs Wellcome.
2657:
3769:
3811:
3166:
1287:
Aciclovir topical cream is commonly associated (≥1% of patients) with: dry or flaking skin or transient stinging/burning sensations. Infrequent adverse effects include
4930:
1121:
Aciclovir taken by mouth does not appear to decrease the risk of pain after shingles. In those with herpes of the eye, aciclovir may be more effective and safer than
1691:
6164:
273:
1870:
Rafailidis PI, Mavros MN, Kapaskelis A, Falagas ME (November 2010). "Antiviral treatment for severe EBV infections in apparently immunocompetent patients".
3196:
2697:
1002:
and is marketed under many brand names worldwide. In 2021, it was the 169th most commonly prescribed medication in the United States, with more than 3
1319:: Synergistic effects when administered with aciclovir and caution should be taken when administering aciclovir to patients receiving IV interferon.
2483:"Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials"
1619:
It was originally marketed as
Zovirax; patents expired in the 1990s and since then it is generic and is marketed under many brand names worldwide.
6021:
1734:
4923:
2973:
Chowdhury MA, Derar N, Hasan S, Hinch B, Ratnam S, Assaly R (2016). "Acyclovir-Induced
Neurotoxicity: A Case Report and Review of Literature".
1224:, sore throat, constipation, abdominal pain, hair loss, rash and weakness. Rare adverse effects (<0.1% of patients) include coma, seizures,
144:
1782:
de Clercq E, Field HJ (5 October 2005). "Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy".
1279:(9-CMMG) has been shown to play a role in neurological adverse events, particularly in older people and those with reduced renal function.
870:
3682:, Schaeffer HJ, "2-Amido-9-(2-acyloxyethoxymethyl)hypoxanthines", issued 27 March 1979, assigned to Burrough Wellcome Co.
1568:, S. Bittner and S. Gurwara on the adenosine analog acycloadenosine which showed promising antiviral activity. Later, Schaeffer joined
4916:
4340:
2646:
5489:
3757:
6014:
3801:
1964:
1669:
846:
1913:
4874:
3890:
3158:
2938:
Berry L, Venkatesan P (December 2014). "Aciclovir-induced neurotoxicity: Utility of CSF and serum CMMG levels in diagnosis".
2172:
2143:
2080:
1588:
995:
2466:
1848:
5631:
5404:
1253:
3064:
GlaxoSmithKline. Zovirax® (acyclovir sodium) for injection prescribing information. Research
Triangle Park, NC; 2003 Nov
967:. Greater care is recommended in those with poor liver or kidney function. It is generally considered safe for use in
6028:
4400:
3949:
3909:
3511:
3118:
2000:
1944:
1171:
Studies in mice, rabbits and rats (with doses more than 10 times the equivalent of that used in humans) given during
915:
890:
210:
6144:
6035:
4891:
1155:. This finding emphasizes the importance of testing simple, inexpensive non-ART strategies, such as aciclovir and
6052:
5961:
3959:
3417:
3188:
1784:
1564:, were the basis for the synthesis of aciclovir. It was codiscovered by Howard Schaeffer following his work with
469:
333:
191:
3074:
Bach MC (February 1987). "Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS".
6007:
3585:
Laport MS, Santos OC, Muricy G (January 2009). "Marine sponges: potential sources of new antimicrobial drugs".
266:
2708:
1204:(≥1% of patients) associated with systemic aciclovir therapy (oral or IV) include nausea, vomiting, diarrhea,
963:
Common side effects include nausea and diarrhea. Potentially serious side effects include kidney problems and
567:
5369:
4318:
3296:"Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy"
1276:
1156:
3134:
4333:
3763:
3717:
1546:
Aciclovir was seen as the start of a new era in antiviral therapy, as it is extremely selective and low in
1245:
772:
618:
5549:
3345:"Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy"
1075:
733:
1097:
Prevention of herpes viruses in immunocompromised people (such as people undergoing cancer chemotherapy)
6149:
6102:
5239:
3919:
Périgaud C, Gosselin G, Imbach JL (1992). "Nucleoside analogues as chemotherapeutic agents: a review".
3219:
2380:"Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis"
1249:
131:
3679:
3473:
3247:"Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management"
1726:
694:
5726:
2823:
Brigden D, Rosling AE, Woods NC (July 1982). "Renal function after acyclovir intravenous injection".
2044:
2016:
1579:. A U.S. patent on aciclovir listing Schaeffer as inventor was issued in 1979. Vince later invented
17:
3438:
Schaeffer HJ, Gurwara S, Vince R, Bittner S (April 1971). "Novel substrate of adenosine deaminase".
2246:
547:
6063:
5956:
5730:
5613:
5509:
5499:
5399:
4373:
3386:"Development and Optimization of Acyclovir Loaded Mucoadhesive Microspheres by Box -Behnken Design"
1565:
1140:
1106:
749:
3731:
2725:
Gartner LM, Morton J, Lawrence RA, Naylor AJ, O'Hare D, Schanler RJ, et al. (February 2005).
5494:
4879:
4326:
3881:
Harvey SC (1990). "Drug absorption, action and disposition". In
Remington JP, Gennaro AR (eds.).
2897:
Helldén A, Odar-Cederlöf I, Diener P, Barkholt L, Medin C, Svensson JO, et al. (June 2003).
1045:
247:
108:
2232:
Gershburg E, Pagano JS (August 2005). "Epstein-Barr virus infections: prospects for treatment".
5780:
5569:
5539:
5121:
5073:
4494:
4166:
2241:
1452:
1447:
1374:
1187:
nursing mothers have herpetic lesions near or on the breast, breast-feeding should be avoided.
1152:
1144:
1102:
1027:
953:
715:
413:
3016:
Pottage JC, Kessler HA, Goodrich JM, Chase R, Benson CA, Kapell K, et al. (August 1986).
1990:
6154:
6057:
5484:
4826:
4775:
4631:
1507:
1479:
1457:
1208:(with IV use only), injection site reactions (with IV use only) and headache. In high doses,
1201:
898:
InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
674:
558:
122:
4908:
5409:
4770:
4627:
4092:
3633:
1441:
1435:
1389:
1261:
1023:
937:
933:
627:
499:
435:
1602:
came into medical use in 1995. It is converted to aciclovir in the body after absorption.
607:
8:
5454:
5009:
4756:
4719:
4471:
4174:
2609:
1560:
1143:. It is also effective in systemic or traumatic herpes infections, eczema herpeticum and
976:
490:
258:
254:
166:
5721:
4667:
3637:
2352:
2327:
1361:
Mechanisms (HSV DNA polymerase inhibition and HSV DNA incorporation) of acyclovir action
776:
753:
4821:
3864:
3839:
3620:
Elion GB, Furman PA, Fyfe JA, de
Miranda P, Beauchamp L, Schaeffer HJ (December 1977).
3567:
3517:
3502:
3325:
3271:
3246:
2998:
2800:
2775:
2756:
2558:
2531:
2453:
2404:
2379:
2303:
2278:
2214:
2161:
1802:
1569:
1293:
1237:
1212:
have been reported. Infrequent adverse effects (0.1–1% of patients) include agitation,
999:
991:
262:
221:
3656:
3621:
3042:
3017:
2507:
2482:
1788:. Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11.
5813:
5362:
5336:
5291:
4992:
4034:
3994:
3945:
3905:
3886:
3869:
3661:
3602:
3507:
3455:
3366:
3361:
3344:
3329:
3317:
3312:
3295:
3276:
3114:
3091:
3047:
2990:
2955:
2920:
2879:
2875:
2840:
2836:
2805:
2748:
2621:
2590:
2563:
2512:
2458:
2409:
2357:
2308:
2259:
2206:
2168:
2139:
1996:
1960:
1940:
1887:
1807:
1661:
1576:
1213:
1087:
705:
385:
372:
360:
183:
5504:
3571:
3521:
3159:"Acyclovir (acyclovir) Capsule Acyclovir (acyclovir) Tablet [Genpharm Inc.]"
3002:
2498:
6159:
6087:
5912:
5800:
5083:
4293:
3928:
3859:
3851:
3651:
3641:
3622:"Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine"
3594:
3559:
3497:
3447:
3397:
3356:
3307:
3266:
3258:
3083:
3037:
3029:
2982:
2947:
2910:
2871:
2832:
2795:
2787:
2760:
2738:
2553:
2543:
2502:
2494:
2448:
2440:
2399:
2395:
2391:
2347:
2343:
2339:
2298:
2294:
2290:
2251:
2218:
2198:
2052:
2024:
1905:
1879:
1797:
1789:
1366:
1067:
964:
789:
395:
316:
306:
296:
286:
68:
3989:
2072:
1727:"Zovirax (acyclovir) dosing, indications, interactions, adverse effects, and more"
1506:
Details of the synthesis of aciclovir were first published by scientists from the
1014:
6116:
5940:
5902:
5897:
5564:
5419:
5316:
5212:
4997:
4970:
4648:
4410:
4364:
4360:
4247:
4064:
4039:
2986:
2428:
2102:
1844:
1555:
1470:
1381:
1345:
949:
524:
423:
403:
158:
5479:
5474:
5469:
4947:
3418:"Aciclovir Tablets BP 400mg - Summary of Product Characteristics (SmPC) - (emc)"
3087:
1151:
transmission, but it can help slow HIV disease progression in people not taking
50:
6128:
5976:
5922:
5887:
5159:
5149:
5134:
5004:
4943:
4885:
4437:
4352:
4209:
4189:
4071:
4029:
3998:
3626:
Proceedings of the
National Academy of Sciences of the United States of America
3598:
2548:
1385:
1268:
1205:
1035:
4348:
3932:
3402:
3385:
2951:
2202:
1883:
6138:
5971:
5892:
5559:
5554:
5459:
5331:
5286:
5225:
5144:
5129:
4975:
4939:
4803:
4602:
4382:
4298:
4199:
4194:
4179:
4107:
4103:
3788:
2481:
Spruance SL, Nett R, Marbury T, Wolff R, Johnson J, Spaulding T (July 2002).
2049:
World Health
Organization model list of essential medicines: 22nd list (2021)
1696:
1378:
1326:
1209:
1172:
1081:
972:
957:
857:
765:
3646:
3550:
Sepčić K (2000). "Bioactive Alkylpyridinium Compounds from Marine Sponges".
1388:. Its monophosphate form also incorporates into the viral DNA, resulting in
5981:
5966:
5917:
5686:
5355:
5311:
5265:
5250:
5245:
5235:
5230:
5220:
5197:
5139:
5111:
5061:
5049:
4987:
4982:
4842:
4613:
4490:
4428:
4356:
4303:
4257:
4157:
4128:
4096:
4044:
4020:
4002:
3873:
3606:
3280:
2994:
2959:
2924:
2809:
2752:
2743:
2726:
2678:
2625:
2594:
2567:
2516:
2444:
2413:
2361:
2312:
2263:
2210:
2021:
World Health Organization model list of essential medicines: 21st list 2019
1891:
1811:
1793:
1599:
1573:
1547:
1535:
1478:
distribution rate; protein binding is reported to range from 9 to 33%. The
1304:
1233:
1110:
311:
301:
291:
281:
3563:
3459:
3370:
3321:
3113:(8th ed.). Foster City, CA: Biomedical Publications. pp. 29–31.
3095:
3051:
2883:
2844:
2791:
2462:
33:
5930:
5907:
5579:
5321:
5306:
5281:
5255:
5187:
5182:
5172:
5100:
5095:
5090:
4956:
4851:
4743:
4709:
4695:
4690:
4485:
4446:
4442:
4433:
4272:
4227:
4222:
4138:
3665:
3262:
3033:
2915:
2898:
2255:
2138:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust.
1531:
1474:
1428:
1257:
1225:
1132:
1122:
1115:
1091:
1039:
177:
41:
3451:
2608:
Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H (April 2009).
2057:
2029:
587:
5986:
5935:
5843:
5795:
5609:
5599:
5594:
5584:
5464:
5326:
5301:
5296:
5202:
5192:
5177:
5078:
5044:
5039:
5034:
5019:
4965:
4856:
4813:
4733:
4682:
4672:
4643:
4607:
4591:
4581:
4540:
4525:
4460:
4242:
4133:
4080:
4060:
4011:
3990:
3189:"Aciclovir Tablets BP 400mg - Summary of Product Characteristics (SPC)"
1551:
1527:
1322:
1316:
1310:
1229:
1221:
1136:
1063:
1051:
941:
822:
598:
3855:
6069:
5853:
5833:
5790:
5785:
5765:
5760:
5701:
5671:
5651:
5604:
5589:
5574:
5260:
5106:
5066:
5056:
5024:
4847:
4798:
4748:
4738:
4728:
4639:
4596:
4586:
4561:
4515:
4500:
4349:
4252:
4237:
4232:
4143:
4118:
4114:
2776:"Antiviral drugs for viruses other than human immunodeficiency virus"
1757:
1515:
1350:
1241:
1183:
during pregnancy, especially during the second and third trimesters.
1180:
1126:
980:
968:
510:
448:
148:
2859:
5838:
5828:
5823:
5818:
5775:
5711:
5706:
5681:
5661:
5646:
5641:
5544:
5029:
5014:
4765:
4658:
4535:
4267:
4184:
4085:
4075:
3806:
1580:
1288:
1057:
945:
654:
647:
578:
205:
2896:
845:
721:
27:
Antiviral medication used against herpes, chickenpox, and shingles
5808:
5770:
5752:
5716:
5676:
5656:
5636:
5378:
4509:
4480:
4455:
4419:
4262:
3787:
This article incorporates text from this source, which is in the
3758:"Drug Approval Package: Acyclovir and Hydrocortisone NDA #022436"
2279:"Antiviral agents for infectious mononucleosis (glandular fever)"
1869:
1595:
1370:
1369:
to aciclovir monophosphate, which is then converted by host cell
1125:. It is not clear if aciclovir eye drops are more effective than
1105:
infections is less clear. It has not been found to be useful for
1070:
3698:
Vince R (2008). "A brief history of the development of Ziagen".
3018:"In vitro activity of ketoconazole against herpes simplex virus"
2860:"Acyclovir-induced renal failure. Clinical course and histology"
1486:) of aciclovir depends according to age group; neonates have a t
971:
with no harm having been observed. It appears to be safe during
5848:
5696:
5691:
5666:
5434:
5414:
4520:
4277:
1523:
1217:
685:
453:
3885:(18th ed.). Easton, Pa.: Mack Pub. Co. pp. 697–702.
1413:
1325:: Although administered often with aciclovir in HIV patients,
95:
4938:
1418:
836:
665:
428:
6123:
3437:
3384:
Karmoker JR, Hasan I, Ahmed N, Saifuddin M, Reza MS (2019).
2679:
Centers for Disease Control and Prevention. (January 2006).
2326:
Chen N, Li Q, Yang J, Zhou M, Zhou D, He L (February 2014).
2276:
1357:
956:
infection. It can be taken by mouth, applied as a cream, or
952:
infections following transplant and severe complications of
738:
5858:
3383:
3293:
3015:
2724:
2683:(9th ed.). Public Health Foundation. pp. 171–192.
2681:
Epidemiology and prevention of vaccine-preventable diseases
2328:"Antiviral treatment for preventing postherpetic neuralgia"
1402:
638:
89:
80:
71:
1937:
Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition
1384:. ACV-TP competitively inhibits and inactivates the viral
3619:
3539:. Belmont, CA: Wadsworth Publishing Company. p. 471.
3135:"VALTREX (valacyclovir hydrochloride) Caplets -GSKSource"
2277:
De Paor M, O'Brien K, Fahey T, Smith SM (December 2016).
2158:
2043:
2015:
1417:
Varicella zoster virus-produced plaques in monolayers of
1272:
and dosing based on renal function may reduce this risk.
1148:
984:
3732:"Valacyclovir Hydrochloride Monograph for Professionals"
2972:
2607:
2480:
2033:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1373:
to aciclovir triphosphate (ACV-TP, also known as aciclo-
996:
World Health Organization's List of Essential Medicines
983:. It works by decreasing the production of the virus's
5347:
3918:
3377:
6100:
3537:
Oceanography: An Invitation to Marine Science, 3rd ed
2858:
Sawyer MH, Webb DE, Balow JE, Straus SE (June 1988).
2857:
1847:. The American Society of Health-System Pharmacists.
1179:
Aciclovir is recommended by the CDC for treatment of
994:, and approved for medical use in 1981. It is on the
83:
77:
3492:
Vardanyan R, Hruby V (2016). "34: Antiviral Drugs".
2647:"PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS"
2187:
1469:
Aciclovir is poorly water-soluble and has poor oral
1094:(a chronic (long-term) form of herpes eye infection)
92:
86:
3390:
Dhaka University Journal of Pharmaceutical Sciences
2822:
566:
74:
3900:Huovinen P, Valtonen V (1994). Neuvonen PJ (ed.).
3584:
2160:
1587:drug for HIV patients. Elion was awarded the 1988
3904:(in Finnish). Helsinki: Kandidaattikustannus Oy.
3342:
1332:
477:2-amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-3
6136:
3899:
3837:
2373:
2371:
1572:and continued the development of aciclovir with
1427:Aciclovir is active against most species in the
546:
523:
6022:GlaxoSmithKline Services Unlimited v Commission
3738:. American Society of Health-System Pharmacists
3433:
3431:
3111:Disposition of toxic drugs and chemicals in man
2937:
2231:
1988:
498:
3939:
3491:
3343:Wagstaff AJ, Faulds D, Goa KL (January 1994).
3294:O'Brien JJ, Campoli-Richards DM (March 1989).
2529:
2325:
1781:
1777:
1775:
6165:World Health Organization essential medicines
5363:
4924:
4334:
3975:
2656:. Ranbaxy Australia Pty Ltd. 26 August 2011.
2368:
2167:(65 ed.). London: Pharmaceutical Press.
1939:. Jones & Bartlett Learning. p. 59.
1906:"Prescribing medicines in pregnancy database"
1534:, which was then converted to an amide using
3802:"Xerese- acyclovir and hydrocortisone cream"
3794:
3678:
3472:
3428:
2718:
2601:
2583:Treatment Guidelines from the Medical Letter
2270:
1084:HSV infections in immunocompromised patients
936:. It is primarily used for the treatment of
209:
3244:
3217:
2851:
2816:
2384:The Cochrane Database of Systematic Reviews
2332:The Cochrane Database of Systematic Reviews
2283:The Cochrane Database of Systematic Reviews
1863:
1772:
1591:, partly for the development of aciclovir.
1267:Intravenous aciclovir may cause reversible
5370:
5356:
4931:
4917:
4341:
4327:
3982:
3968:
3944:(5th ed.). Pearson Professional Ltd.
3838:Hazra S, Konrad M, Lavie A (August 2010).
3578:
3287:
3211:
1839:
1837:
1835:
1833:
1831:
1829:
1827:
1825:
1823:
1821:
775:
752:
606:
49:
40:
3863:
3655:
3645:
3543:
3501:
3401:
3360:
3311:
3270:
3041:
2914:
2799:
2773:
2767:
2742:
2727:"Breastfeeding and the use of human milk"
2557:
2547:
2536:Journal of the International AIDS Society
2506:
2452:
2403:
2377:
2351:
2302:
2245:
2234:The Journal of Antimicrobial Chemotherapy
2056:
2028:
1801:
1431:family. In descending order of activity:
626:
3724:
3534:
2692:
2690:
2429:"Acyclovir in recurrent herpes labialis"
2133:
1934:
1635:Subject to the same conditions as before
1490:of 4 hours, children 1–12 years have a t
1412:
1377:). ACV-TP is a very potent inhibitor of
1356:
1344:
1013:
6015:Christopher v. SmithKline Beecham Corp.
3410:
3224:Martindale: The Complete Drug Reference
2426:
2037:
2009:
1982:
1818:
1656:
1654:
1652:
1022:Aciclovir is used for the treatment of
748:
586:
182:
14:
6137:
3880:
3549:
3108:
2641:
2639:
2637:
2635:
2581:"Drugs for non-HIV viral infections".
2181:
2129:
2127:
2125:
2123:
1995:. John Wiley & Sons. p. 504.
1928:
1672:from the original on 23 September 2015
1609:
1340:
766:
366:
126:
5490:Recherche et Industrie Thérapeutiques
5351:
4912:
4322:
3963:
3814:from the original on 13 December 2019
3772:from the original on 13 December 2019
3718:"The Nobel Prize - Gertrude B. Elion"
3697:
3251:Antimicrobial Agents and Chemotherapy
3199:from the original on 22 February 2014
3169:from the original on 21 February 2014
3022:Antimicrobial Agents and Chemotherapy
2903:Nephrology, Dialysis, Transplantation
2687:
2487:Antimicrobial Agents and Chemotherapy
2051:. Geneva: World Health Organization.
2023:. Geneva: World Health Organization.
1737:from the original on 19 February 2014
1721:
1719:
1717:
1715:
1522:In the first step shown, 2,6-dichloro
714:
693:
673:
379:
200:
165:
157:
135:
3940:Rang HP, Dale MM, Ritter JM (2003).
3587:Current Pharmaceutical Biotechnology
3496:. Academic Press. pp. 706–708.
3073:
2083:from the original on 15 January 2024
1649:
1494:of 2–3 hours whereas adults have a t
1299:
720:
537:
315:
305:
295:
285:
5405:GlaxoSmithKline Pharmaceuticals Ltd
3883:Remington's Pharmaceutical Sciences
3245:Piret J, Boivin G (February 2011).
3181:
3102:
3076:The New England Journal of Medicine
2660:from the original on 20 August 2016
2632:
2152:
2120:
2103:"Acyclovir - Drug Usage Statistics"
1961:"Acyclovir use while Breastfeeding"
1464:
1254:thrombotic thrombocytopenic purpura
1195:
948:. Other uses include prevention of
653:
646:
514:
24:
3830:
3503:10.1016/B978-0-12-411492-0.00034-1
3226:. London, UK: Pharmaceutical Press
3218:Sweetman, S, ed. (7 August 2013).
3195:. Actavis UK Ltd. 20 August 2012.
3151:
2530:Mascolinli M, Kort R (June 2010).
2159:Joint Formulary Committee (2013).
1712:
1403:acquired immunodeficiency syndrome
1282:
1190:
990:Aciclovir was patented in 1974 by
25:
6176:
6029:United States v. Glaxo Group Ltd.
2614:MMWR. Recommendations and Reports
1967:from the original on 5 March 2016
1916:from the original on 8 April 2014
1755:
342:
232:
6122:
6110:
6083:
6082:
6036:United States v. GlaxoSmithKline
3782:
3362:10.2165/00003495-199447010-00009
3313:10.2165/00003495-198937030-00002
2975:American Journal of Therapeutics
2864:The American Journal of Medicine
2825:The American Journal of Medicine
2469:from the original on 2007-05-15.
2163:British National Formulary (BNF)
1514:
1365:Aciclovir is converted by viral
806:
800:
67:
6053:Drug Industry Documents Archive
3750:
3710:
3691:
3672:
3613:
3528:
3485:
3466:
3336:
3238:
3193:electronic Medicines Compendium
3165:. Genpharm Inc. November 2006.
3127:
3067:
3058:
3009:
2966:
2931:
2890:
2672:
2574:
2523:
2499:10.1128/aac.46.7.2238-2243.2002
2474:
2420:
2319:
2225:
2095:
2065:
1989:Fischer J, Ganellin CR (2006).
1953:
1851:from the original on 2015-01-05
1785:British Journal of Pharmacology
1629:
1408:
903:Key:MKUXAQIIEYXACX-UHFFFAOYSA-N
6008:Canada v. GlaxoSmithKline Inc.
3844:Journal of Medicinal Chemistry
3494:Synthesis of Best-Seller Drugs
3440:Journal of Medicinal Chemistry
2396:10.1002/14651858.CD002898.pub5
2344:10.1002/14651858.CD006866.pub3
2295:10.1002/14651858.CD011487.pub2
1898:
1749:
1684:
1333:Detection in biological fluids
1101:Its effectiveness in treating
1009:
812:
794:
355:
13:
1:
2774:Razonable RR (October 2011).
2378:Wilhelmus KR (January 2015).
2136:Australian Medicines Handbook
1992:Analogue-based Drug Discovery
1642:
1395:
1277:9-Carboxymethoxymethylguanine
1153:anti-retroviral therapy (ART)
862:256.5 °C (493.7 °F)
3764:Food and Drug Administration
2987:10.1097/MJT.0000000000000093
2940:Journal of Clinical Virology
2876:10.1016/0002-9343(88)90313-0
2837:10.1016/0002-9343(82)90087-0
1872:Journal of Clinical Virology
1501:
1162:
878:O=C2/N=C(\Nc1n(cnc12)COCCO)N
121:Acycloguanosine, acyclovir (
7:
3921:Nucleosides and Nucleotides
3088:10.1056/NEJM198702263160912
2707:. FDA. 2005. Archived from
2620:(RR-4): 1–207, quiz CE1–4.
1109:due to Epstein-Barr virus.
1076:Herpes simplex encephalitis
10:
6181:
3599:10.2174/138920109787048625
2549:10.1186/1758-2652-13-S1-S4
2427:Worrall G (January 1996).
2061:. WHO/MHP/HPS/EML/2021.02.
1554:isolated from a Caribbean
1541:
1250:toxic epidermal necrolysis
784:Chemical and physical data
456:(62–90% as unchanged drug)
6078:
6045:
5999:
5949:
5878:
5871:
5745:
5624:
5532:
5525:
5518:
5510:Smith, Kline & French
5445:
5429:
5392:
5385:
5274:
5211:
5158:
5120:
4955:
4869:
4835:
4812:
4791:
4784:
4708:
4681:
4657:
4626:
4574:
4554:
4470:
4409:
4399:
4390:
4381:
4372:
4286:
4208:
4165:
4156:
4053:
4019:
4010:
3933:10.1080/07328319208021748
3403:10.3329/dujps.v18i1.41421
2952:10.1016/j.jcv.2014.09.001
2589:(32): 23–32. April 2005.
2203:10.1007/s00520-010-0900-3
2191:Supportive Care in Cancer
2045:World Health Organization
2017:World Health Organization
1884:10.1016/j.jcv.2010.07.008
1606:years of age and older).
1275:The aciclovir metabolite
1050:Herpes simplex labialis (
1018:400 mg pills of aciclovir
911:
886:
866:
856:
834:
821:
788:
783:
764:
732:
704:
684:
664:
637:
617:
597:
577:
557:
534:
509:
489:
465:
460:
447:
434:
422:
412:
402:
394:
332:
327:
272:
246:
220:
190:
176:
143:
117:
107:
62:
57:
48:
39:
5500:S. E. Massengill Company
5400:GlaxoSmithKline Pakistan
1622:
1614:
1246:Stevens–Johnson syndrome
1216:, confusion, dizziness,
1141:herpesviral encephalitis
1107:infectious mononucleosis
6145:Anti-herpes virus drugs
5495:Reliant Pharmaceuticals
5377:
4792:Nucleic acid inhibitors
3647:10.1073/pnas.74.12.5716
2780:Mayo Clinic Proceedings
1589:Nobel Prize in Medicine
1296:or allergic reactions.
1046:Neonatal herpes simplex
1030:infections, including:
1006:million prescriptions.
998:. It is available as a
3902:Kliininen Farmakologia
2744:10.1542/peds.2004-2491
2654:TGA eBusiness Services
2445:10.1136/bmj.312.7022.6
2134:Rossi, S, ed. (2013).
1794:10.1038/sj.bjp.0706446
1448:Varicella zoster virus
1424:
1362:
1354:
1353:and aciclovir compared
1202:adverse drug reactions
1159:, in people with HIV.
1145:herpesviral meningitis
1028:varicella zoster virus
1019:
6058:GlaxoSmithKline Prize
5485:Human Genome Sciences
4827:Peginterferon alfa-2a
4776:Tenofovir alafenamide
3564:10.1081/TXR-100100318
3474:US patent 4199574
2792:10.4065/mcp.2011.0309
2073:"The Top 300 of 2021"
1910:Australian Government
1508:University at Buffalo
1480:elimination half-life
1458:Human cytomegalovirus
1416:
1360:
1348:
1017:
5455:Allen & Hanburys
5410:Stiefel Laboratories
4771:Tenofovir disoproxil
4757:Nucleotide analogues
4720:Nucleoside analogues
3810:. 12 December 2019.
3768:. 13 December 2019.
3422:www.medicines.org.uk
3263:10.1128/AAC.00615-10
3034:10.1128/aac.30.2.215
1442:Herpes simplex virus
1436:Herpes simplex virus
1024:herpes simplex virus
938:herpes simplex virus
934:antiviral medication
5010:Dihydrostreptomycin
4472:Pyrimidine analogue
4175:Silver sulfadiazine
3638:1977PNAS...74.5716E
3535:Garrison T (1999).
3452:10.1021/jm00286a024
1935:Hamilton R (2015).
1610:Society and culture
1561:Cryptotethya crypta
1341:Mechanism of action
1090:and herpes simplex
977:nucleoside analogue
375:(Prescription only)
351:(Prescription only)
36:
5962:Silas M. Burroughs
5505:SmithKline Beecham
5470:Burroughs Wellcome
4896:Never to phase III
4822:Interferon alfa 2b
3109:Baselt RC (2008).
2916:10.1093/ndt/gfg119
2256:10.1093/jac/dki240
1760:(in German). Kevin
1731:Medscape Reference
1570:Burroughs Wellcome
1453:Epstein–Barr virus
1425:
1363:
1355:
1294:punctate keratitis
1103:Epstein–Barr virus
1020:
1000:generic medication
992:Burroughs Wellcome
954:Epstein–Barr virus
164:Acyclovir topical
32:
6150:CYP1A2 inhibitors
6098:
6097:
5995:
5994:
5867:
5866:
5741:
5740:
5441:
5440:
5345:
5344:
5337:Sodium propionate
5292:Dibrompropamidine
4993:Chlortetracycline
4940:Ophthalmologicals
4906:
4905:
4865:
4864:
4704:
4703:
4622:
4621:
4570:
4569:
4550:
4549:
4316:
4315:
4312:
4311:
4158:Chemotherapeutics
4152:
4151:
4035:Chlortetracycline
3995:chemotherapeutics
3892:978-0-912734-04-0
3856:10.1021/jm1005379
3850:(15): 5792–5800.
3632:(12): 5716–5720.
2786:(10): 1009–1026.
2698:"Acyclovir label"
2174:978-0-85711-084-8
2145:978-0-9805790-9-3
1577:Gertrude B. Elion
1390:chain termination
1300:Drug interactions
1262:Cotard's syndrome
1088:Herpes of the eye
1068:immunocompromised
975:. Aciclovir is a
923:
922:
847:Interactive image
734:CompTox Dashboard
408:15–20% (by mouth)
383:
370:
358:
346:
236:
203:
138:
129:
16:(Redirected from
6172:
6127:
6126:
6115:
6114:
6113:
6106:
6086:
6085:
5913:Patrick Vallance
5876:
5875:
5605:Wellbutrin/Zyban
5530:
5529:
5523:
5522:
5390:
5389:
5372:
5365:
5358:
5349:
5348:
5213:Fluoroquinolones
5084:Benzylpenicillin
4933:
4926:
4919:
4910:
4909:
4836:Multiple/unknown
4789:
4788:
4785:Multiple/general
4555:Not TK activated
4407:
4406:
4397:
4396:
4388:
4387:
4379:
4378:
4343:
4336:
4329:
4320:
4319:
4294:Ingenol mebutate
4163:
4162:
4017:
4016:
3984:
3977:
3970:
3961:
3960:
3955:
3936:
3927:(2–4): 903–945.
3915:
3896:
3877:
3867:
3824:
3823:
3821:
3819:
3798:
3792:
3786:
3785:
3781:
3779:
3777:
3754:
3748:
3747:
3745:
3743:
3728:
3722:
3721:
3714:
3708:
3707:
3695:
3689:
3688:
3687:
3683:
3676:
3670:
3669:
3659:
3649:
3617:
3611:
3610:
3582:
3576:
3575:
3547:
3541:
3540:
3532:
3526:
3525:
3505:
3489:
3483:
3482:
3481:
3477:
3470:
3464:
3463:
3435:
3426:
3425:
3414:
3408:
3407:
3405:
3381:
3375:
3374:
3364:
3340:
3334:
3333:
3315:
3291:
3285:
3284:
3274:
3242:
3236:
3235:
3233:
3231:
3215:
3209:
3208:
3206:
3204:
3185:
3179:
3178:
3176:
3174:
3155:
3149:
3148:
3146:
3145:
3131:
3125:
3124:
3106:
3100:
3099:
3071:
3065:
3062:
3056:
3055:
3045:
3013:
3007:
3006:
2981:(3): e941–e943.
2970:
2964:
2963:
2935:
2929:
2928:
2918:
2909:(6): 1135–1141.
2894:
2888:
2887:
2870:(6): 1067–1071.
2855:
2849:
2848:
2820:
2814:
2813:
2803:
2771:
2765:
2764:
2746:
2722:
2716:
2715:
2713:
2702:
2694:
2685:
2684:
2676:
2670:
2669:
2667:
2665:
2651:
2643:
2630:
2629:
2605:
2599:
2598:
2578:
2572:
2571:
2561:
2551:
2527:
2521:
2520:
2510:
2493:(7): 2238–2243.
2478:
2472:
2470:
2456:
2424:
2418:
2417:
2407:
2375:
2366:
2365:
2355:
2323:
2317:
2316:
2306:
2289:(12): CD011487.
2274:
2268:
2267:
2249:
2229:
2223:
2222:
2185:
2179:
2178:
2166:
2156:
2150:
2149:
2131:
2118:
2117:
2115:
2113:
2099:
2093:
2092:
2090:
2088:
2069:
2063:
2062:
2060:
2041:
2035:
2034:
2032:
2013:
2007:
2006:
1986:
1980:
1979:
1974:
1972:
1963:. Mar 10, 2015.
1957:
1951:
1950:
1932:
1926:
1925:
1923:
1921:
1912:. 3 March 2014.
1902:
1896:
1895:
1867:
1861:
1860:
1858:
1856:
1841:
1816:
1815:
1805:
1779:
1770:
1769:
1767:
1765:
1753:
1747:
1746:
1744:
1742:
1723:
1710:
1709:
1707:
1705:
1688:
1682:
1681:
1679:
1677:
1658:
1636:
1633:
1518:
1473:(15–30%), hence
1465:Pharmacokinetics
1460:– least activity
1421:
1367:thymidine kinase
1196:Systemic therapy
1005:
928:, also known as
919:
918:
849:
829:
814:
808:
802:
796:
779:
768:
757:
756:
742:
740:
724:
718:
697:
677:
657:
650:
630:
610:
590:
570:
550:
540:
539:
527:
517:
516:
502:
439:
381:
378:
368:
365:
357:
354:
344:
341:
319:
309:
299:
289:
234:
231:
213:
202:
199:
186:
169:
161:
137:
134:
128:
125:
102:
101:
98:
97:
94:
91:
88:
85:
82:
79:
76:
73:
53:
44:
37:
35:
31:
21:
6180:
6179:
6175:
6174:
6173:
6171:
6170:
6169:
6135:
6134:
6133:
6121:
6111:
6109:
6101:
6099:
6094:
6074:
6041:
5991:
5945:
5941:Laurie Glimcher
5908:Manvinder Banga
5903:Roy M. Anderson
5898:Simon Dingemans
5880:
5863:
5737:
5620:
5514:
5447:
5437:
5425:
5420:ViiV Healthcare
5381:
5376:
5346:
5341:
5317:Povidone-iodine
5270:
5207:
5154:
5116:
5005:aminoglycosides
4998:Oxytetracycline
4971:Chloramphenicol
4951:
4944:anti-infectives
4937:
4907:
4902:
4901:
4886:Clinical trials
4861:
4831:
4808:
4780:
4700:
4677:
4653:
4649:Podophyllotoxin
4618:
4566:
4546:
4466:
4411:Purine analogue
4392:
4368:
4347:
4317:
4308:
4282:
4248:Podophyllotoxin
4204:
4148:
4072:Aminoglycosides
4065:Chloramphenicol
4049:
4040:Oxytetracycline
4023:and derivatives
4006:
3988:
3958:
3952:
3912:
3893:
3833:
3831:Further reading
3828:
3827:
3817:
3815:
3800:
3799:
3795:
3783:
3775:
3773:
3756:
3755:
3751:
3741:
3739:
3730:
3729:
3725:
3716:
3715:
3711:
3696:
3692:
3685:
3677:
3673:
3618:
3614:
3583:
3579:
3548:
3544:
3533:
3529:
3514:
3490:
3486:
3479:
3471:
3467:
3436:
3429:
3416:
3415:
3411:
3382:
3378:
3341:
3337:
3292:
3288:
3243:
3239:
3229:
3227:
3216:
3212:
3202:
3200:
3187:
3186:
3182:
3172:
3170:
3157:
3156:
3152:
3143:
3141:
3133:
3132:
3128:
3121:
3107:
3103:
3072:
3068:
3063:
3059:
3014:
3010:
2971:
2967:
2936:
2932:
2895:
2891:
2856:
2852:
2831:(1A): 182–185.
2821:
2817:
2772:
2768:
2723:
2719:
2711:
2700:
2696:
2695:
2688:
2677:
2673:
2663:
2661:
2649:
2645:
2644:
2633:
2606:
2602:
2580:
2579:
2575:
2542:(Suppl 1): S4.
2528:
2524:
2479:
2475:
2425:
2421:
2390:(1): CD002898.
2376:
2369:
2338:(2): CD006866.
2324:
2320:
2275:
2271:
2247:10.1.1.320.6721
2230:
2226:
2197:(8): 993–1006.
2186:
2182:
2175:
2157:
2153:
2146:
2132:
2121:
2111:
2109:
2101:
2100:
2096:
2086:
2084:
2071:
2070:
2066:
2042:
2038:
2014:
2010:
2003:
1987:
1983:
1970:
1968:
1959:
1958:
1954:
1947:
1933:
1929:
1919:
1917:
1904:
1903:
1899:
1868:
1864:
1854:
1852:
1843:
1842:
1819:
1780:
1773:
1763:
1761:
1758:"The Aciclovir"
1754:
1750:
1740:
1738:
1725:
1724:
1713:
1703:
1701:
1690:
1689:
1685:
1675:
1673:
1660:
1659:
1650:
1645:
1640:
1639:
1634:
1630:
1625:
1617:
1612:
1544:
1504:
1497:
1493:
1489:
1485:
1471:bioavailability
1467:
1444:type II (HSV-2)
1419:
1411:
1398:
1382:DNA replication
1343:
1335:
1302:
1285:
1283:Topical therapy
1198:
1193:
1191:Adverse effects
1165:
1038:(treatment and
1012:
1003:
950:cytomegalovirus
914:
912:
907:
904:
899:
894:
893:
882:
879:
874:
873:
852:
827:
817:
811:
805:
799:
760:
736:
728:
700:
680:
660:
633:
613:
593:
573:
553:
536:
530:
513:
505:
485:
482:
473:
472:
437:
414:Protein binding
404:Bioavailability
396:Pharmacokinetic
390:
323:
249:
242:
223:
216:
172:
113:Zovirax, others
70:
66:
28:
23:
22:
15:
12:
11:
5:
6178:
6168:
6167:
6162:
6157:
6152:
6147:
6132:
6131:
6119:
6096:
6095:
6093:
6092:
6079:
6076:
6075:
6073:
6072:
6067:
6060:
6055:
6049:
6047:
6043:
6042:
6040:
6039:
6032:
6025:
6018:
6011:
6003:
6001:
5997:
5996:
5993:
5992:
5990:
5989:
5984:
5979:
5977:Henry Wellcome
5974:
5969:
5964:
5959:
5957:Thomas Beecham
5953:
5951:
5947:
5946:
5944:
5943:
5938:
5933:
5928:
5925:
5923:Lynn Elsenhans
5920:
5915:
5910:
5905:
5900:
5895:
5890:
5888:Philip Hampton
5884:
5882:
5873:
5869:
5868:
5865:
5864:
5862:
5861:
5856:
5851:
5846:
5841:
5836:
5831:
5826:
5821:
5816:
5814:Goody's Powder
5811:
5806:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5755:
5749:
5747:
5743:
5742:
5739:
5738:
5736:
5735:
5724:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5639:
5634:
5628:
5626:
5622:
5621:
5619:
5618:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5536:
5534:
5527:
5520:
5516:
5515:
5513:
5512:
5507:
5502:
5497:
5492:
5487:
5482:
5480:Glaxo Wellcome
5477:
5472:
5467:
5462:
5457:
5451:
5449:
5443:
5442:
5439:
5438:
5433:
5431:
5427:
5426:
5424:
5423:
5417:
5412:
5407:
5402:
5396:
5394:
5387:
5383:
5382:
5375:
5374:
5367:
5360:
5352:
5343:
5342:
5340:
5339:
5334:
5329:
5324:
5319:
5314:
5309:
5304:
5299:
5294:
5289:
5284:
5278:
5276:
5272:
5271:
5269:
5268:
5263:
5258:
5253:
5248:
5243:
5240:+dexamethasone
5233:
5228:
5223:
5217:
5215:
5209:
5208:
5206:
5205:
5200:
5195:
5190:
5185:
5180:
5175:
5170:
5164:
5162:
5156:
5155:
5153:
5152:
5150:Sulfamethizole
5147:
5142:
5137:
5135:Sulfadicramide
5132:
5126:
5124:
5118:
5117:
5115:
5114:
5109:
5104:
5098:
5087:
5081:
5070:
5064:
5053:
5047:
5042:
5037:
5032:
5027:
5022:
5017:
5012:
5001:
4995:
4990:
4979:
4973:
4961:
4959:
4953:
4952:
4936:
4935:
4928:
4921:
4913:
4904:
4903:
4900:
4899:
4898:
4897:
4894:
4883:
4877:
4871:
4870:
4867:
4866:
4863:
4862:
4860:
4859:
4854:
4845:
4839:
4837:
4833:
4832:
4830:
4829:
4824:
4818:
4816:
4810:
4809:
4807:
4806:
4801:
4795:
4793:
4786:
4782:
4781:
4779:
4778:
4773:
4768:
4752:
4751:
4746:
4741:
4736:
4731:
4715:
4713:
4706:
4705:
4702:
4701:
4699:
4698:
4693:
4687:
4685:
4679:
4678:
4676:
4675:
4663:
4661:
4655:
4654:
4652:
4651:
4646:
4636:
4634:
4624:
4623:
4620:
4619:
4617:
4616:
4611:
4599:
4594:
4589:
4584:
4578:
4576:
4572:
4571:
4568:
4567:
4565:
4564:
4558:
4556:
4552:
4551:
4548:
4547:
4545:
4544:
4531:
4530:
4529:
4528:
4523:
4518:
4505:
4504:
4498:
4488:
4476:
4474:
4468:
4467:
4465:
4464:
4451:
4450:
4440:
4438:Valganciclovir
4431:
4415:
4413:
4404:
4394:
4385:
4376:
4370:
4369:
4346:
4345:
4338:
4331:
4323:
4314:
4313:
4310:
4309:
4307:
4306:
4301:
4296:
4290:
4288:
4284:
4283:
4281:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4214:
4212:
4206:
4205:
4203:
4202:
4197:
4192:
4190:Sulfamethizole
4187:
4182:
4177:
4171:
4169:
4160:
4154:
4153:
4150:
4149:
4147:
4146:
4141:
4136:
4131:
4122:
4121:
4111:
4110:
4100:
4099:
4089:
4088:
4083:
4078:
4068:
4067:
4057:
4055:
4051:
4050:
4048:
4047:
4042:
4037:
4032:
4030:Demeclocycline
4026:
4024:
4014:
4008:
4007:
3999:dermatological
3987:
3986:
3979:
3972:
3964:
3957:
3956:
3950:
3937:
3916:
3910:
3897:
3891:
3878:
3834:
3832:
3829:
3826:
3825:
3793:
3749:
3723:
3709:
3690:
3671:
3612:
3577:
3558:(2): 139–160.
3542:
3527:
3512:
3484:
3465:
3446:(4): 367–369.
3427:
3409:
3376:
3355:(1): 153–205.
3335:
3306:(3): 233–309.
3286:
3257:(2): 459–472.
3237:
3210:
3180:
3150:
3126:
3119:
3101:
3066:
3057:
3028:(2): 215–219.
3008:
2965:
2946:(4): 608–610.
2930:
2889:
2850:
2815:
2766:
2737:(2): 496–506.
2717:
2714:on 2017-09-08.
2686:
2671:
2631:
2600:
2573:
2522:
2473:
2419:
2367:
2318:
2269:
2240:(2): 277–281.
2224:
2180:
2173:
2151:
2144:
2119:
2094:
2064:
2036:
2008:
2001:
1981:
1952:
1945:
1927:
1897:
1878:(3): 151–157.
1862:
1817:
1771:
1748:
1711:
1683:
1647:
1646:
1644:
1641:
1638:
1637:
1627:
1626:
1624:
1621:
1616:
1613:
1611:
1608:
1574:pharmacologist
1543:
1540:
1520:
1519:
1503:
1500:
1495:
1491:
1487:
1483:
1466:
1463:
1462:
1461:
1455:
1450:
1445:
1439:
1438:type I (HSV-1)
1410:
1407:
1397:
1394:
1386:DNA polymerase
1349:Structures of
1342:
1339:
1334:
1331:
1301:
1298:
1284:
1281:
1269:nephrotoxicity
1210:hallucinations
1206:encephalopathy
1197:
1194:
1192:
1189:
1164:
1161:
1099:
1098:
1095:
1085:
1078:
1073:
1060:
1055:
1048:
1043:
1036:herpes simplex
1011:
1008:
921:
920:
909:
908:
906:
905:
902:
900:
897:
889:
888:
887:
884:
883:
881:
880:
877:
869:
868:
867:
864:
863:
860:
854:
853:
851:
850:
842:
840:
832:
831:
825:
819:
818:
815:
809:
803:
797:
792:
786:
785:
781:
780:
770:
762:
761:
759:
758:
745:
743:
730:
729:
727:
726:
710:
708:
702:
701:
699:
698:
690:
688:
682:
681:
679:
678:
670:
668:
662:
661:
659:
658:
651:
643:
641:
635:
634:
632:
631:
623:
621:
615:
614:
612:
611:
603:
601:
595:
594:
592:
591:
583:
581:
575:
574:
572:
571:
563:
561:
555:
554:
552:
551:
543:
541:
532:
531:
529:
528:
520:
518:
507:
506:
504:
503:
495:
493:
487:
486:
484:
483:
476:
468:
467:
466:
463:
462:
458:
457:
451:
445:
444:
441:
432:
431:
426:
420:
419:
416:
410:
409:
406:
400:
399:
392:
391:
389:
388:
376:
363:
352:
338:
336:
330:
329:
325:
324:
322:
321:
278:
276:
270:
269:
252:
250:administration
244:
243:
241:
240:
238:
228:
226:
218:
217:
215:
214:
196:
194:
188:
187:
180:
174:
173:
171:
170:
162:
153:
151:
141:
140:
130:), acyclovir (
119:
115:
114:
111:
105:
104:
64:
60:
59:
55:
54:
46:
45:
26:
9:
6:
4:
3:
2:
6177:
6166:
6163:
6161:
6158:
6156:
6153:
6151:
6148:
6146:
6143:
6142:
6140:
6130:
6125:
6120:
6118:
6108:
6107:
6104:
6091:
6090:
6081:
6080:
6077:
6071:
6068:
6066:
6065:
6061:
6059:
6056:
6054:
6051:
6050:
6048:
6044:
6038:
6037:
6033:
6031:
6030:
6026:
6024:
6023:
6019:
6017:
6016:
6012:
6010:
6009:
6005:
6004:
6002:
5998:
5988:
5985:
5983:
5980:
5978:
5975:
5973:
5972:John K. Smith
5970:
5968:
5965:
5963:
5960:
5958:
5955:
5954:
5952:
5948:
5942:
5939:
5937:
5934:
5932:
5929:
5927:Jesse Goodman
5926:
5924:
5921:
5919:
5916:
5914:
5911:
5909:
5906:
5904:
5901:
5899:
5896:
5894:
5893:Emma Walmsley
5891:
5889:
5886:
5885:
5883:
5877:
5874:
5870:
5860:
5857:
5855:
5852:
5850:
5847:
5845:
5842:
5840:
5837:
5835:
5832:
5830:
5827:
5825:
5822:
5820:
5817:
5815:
5812:
5810:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5756:
5754:
5751:
5750:
5748:
5744:
5734:
5733:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5629:
5627:
5623:
5617:
5616:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5585:Paxil/Seroxat
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5537:
5535:
5531:
5528:
5524:
5521:
5517:
5511:
5508:
5506:
5503:
5501:
5498:
5496:
5493:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5460:Beecham Group
5458:
5456:
5453:
5452:
5450:
5446:Predecessors,
5444:
5436:
5432:
5428:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5401:
5398:
5397:
5395:
5391:
5388:
5384:
5380:
5373:
5368:
5366:
5361:
5359:
5354:
5353:
5350:
5338:
5335:
5333:
5332:Sodium borate
5330:
5328:
5325:
5323:
5320:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5287:Chlorhexidine
5285:
5283:
5280:
5279:
5277:
5273:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5241:
5237:
5234:
5232:
5229:
5227:
5226:Ciprofloxacin
5224:
5222:
5219:
5218:
5216:
5214:
5210:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5165:
5163:
5161:
5157:
5151:
5148:
5146:
5145:Sulfafurazole
5143:
5141:
5138:
5136:
5133:
5131:
5130:Sulfacetamide
5128:
5127:
5125:
5123:
5119:
5113:
5110:
5108:
5105:
5102:
5099:
5097:
5093:
5092:
5088:
5085:
5082:
5080:
5076:
5075:
5071:
5068:
5065:
5063:
5059:
5058:
5054:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5007:
5006:
5002:
4999:
4996:
4994:
4991:
4989:
4985:
4984:
4983:tetracyclines
4980:
4977:
4976:Azidamfenicol
4974:
4972:
4968:
4967:
4963:
4962:
4960:
4958:
4954:
4949:
4945:
4941:
4934:
4929:
4927:
4922:
4920:
4915:
4914:
4911:
4895:
4893:
4890:
4889:
4887:
4884:
4881:
4878:
4876:
4873:
4872:
4868:
4858:
4855:
4853:
4849:
4846:
4844:
4841:
4840:
4838:
4834:
4828:
4825:
4823:
4820:
4819:
4817:
4815:
4811:
4805:
4804:Brincidofovir
4802:
4800:
4797:
4796:
4794:
4790:
4787:
4783:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4758:
4754:
4753:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4721:
4717:
4716:
4714:
4711:
4707:
4697:
4694:
4692:
4689:
4688:
4686:
4684:
4680:
4674:
4671:
4669:
4665:
4664:
4662:
4660:
4656:
4650:
4647:
4645:
4641:
4638:
4637:
4635:
4633:
4629:
4625:
4615:
4612:
4609:
4605:
4604:
4603:early protein
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4579:
4577:
4573:
4563:
4560:
4559:
4557:
4553:
4542:
4538:
4537:
4533:
4532:
4527:
4524:
4522:
4519:
4517:
4514:
4513:
4512:
4511:
4507:
4506:
4502:
4499:
4496:
4492:
4489:
4487:
4483:
4482:
4478:
4477:
4475:
4473:
4469:
4462:
4458:
4457:
4453:
4452:
4448:
4444:
4441:
4439:
4435:
4432:
4430:
4426:
4422:
4421:
4417:
4416:
4414:
4412:
4408:
4405:
4402:
4398:
4395:
4391:DNA-synthesis
4389:
4386:
4384:
4380:
4377:
4375:
4371:
4366:
4362:
4358:
4354:
4351:
4344:
4339:
4337:
4332:
4330:
4325:
4324:
4321:
4305:
4302:
4300:
4299:Metronidazole
4297:
4295:
4292:
4291:
4289:
4285:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4215:
4213:
4211:
4207:
4201:
4200:Sulfamerazine
4198:
4196:
4195:Sulfanilamide
4193:
4191:
4188:
4186:
4183:
4181:
4180:Sulfathiazole
4178:
4176:
4173:
4172:
4170:
4168:
4164:
4161:
4159:
4155:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4124:
4123:
4120:
4116:
4113:
4112:
4109:
4108:Virginiamycin
4105:
4104:Streptogramin
4102:
4101:
4098:
4094:
4091:
4090:
4087:
4084:
4082:
4079:
4077:
4073:
4070:
4069:
4066:
4062:
4059:
4058:
4056:
4052:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4027:
4025:
4022:
4018:
4015:
4013:
4009:
4004:
4000:
3996:
3992:
3985:
3980:
3978:
3973:
3971:
3966:
3965:
3962:
3953:
3951:0-443-07145-4
3947:
3943:
3938:
3934:
3930:
3926:
3922:
3917:
3913:
3911:951-8951-09-8
3907:
3903:
3898:
3894:
3888:
3884:
3879:
3875:
3871:
3866:
3861:
3857:
3853:
3849:
3845:
3841:
3836:
3835:
3813:
3809:
3808:
3803:
3797:
3790:
3789:public domain
3771:
3767:
3765:
3759:
3753:
3737:
3733:
3727:
3719:
3713:
3705:
3701:
3694:
3681:
3675:
3667:
3663:
3658:
3653:
3648:
3643:
3639:
3635:
3631:
3627:
3623:
3616:
3608:
3604:
3600:
3596:
3593:(1): 86–105.
3592:
3588:
3581:
3573:
3569:
3565:
3561:
3557:
3553:
3552:Toxin Reviews
3546:
3538:
3531:
3523:
3519:
3515:
3513:9780124114920
3509:
3504:
3499:
3495:
3488:
3475:
3469:
3461:
3457:
3453:
3449:
3445:
3441:
3434:
3432:
3423:
3419:
3413:
3404:
3399:
3395:
3391:
3387:
3380:
3372:
3368:
3363:
3358:
3354:
3350:
3346:
3339:
3331:
3327:
3323:
3319:
3314:
3309:
3305:
3301:
3297:
3290:
3282:
3278:
3273:
3268:
3264:
3260:
3256:
3252:
3248:
3241:
3225:
3221:
3214:
3198:
3194:
3190:
3184:
3168:
3164:
3160:
3154:
3140:
3139:gsksource.com
3136:
3130:
3122:
3120:9780962652370
3116:
3112:
3105:
3097:
3093:
3089:
3085:
3081:
3077:
3070:
3061:
3053:
3049:
3044:
3039:
3035:
3031:
3027:
3023:
3019:
3012:
3004:
3000:
2996:
2992:
2988:
2984:
2980:
2976:
2969:
2961:
2957:
2953:
2949:
2945:
2941:
2934:
2926:
2922:
2917:
2912:
2908:
2904:
2900:
2893:
2885:
2881:
2877:
2873:
2869:
2865:
2861:
2854:
2846:
2842:
2838:
2834:
2830:
2826:
2819:
2811:
2807:
2802:
2797:
2793:
2789:
2785:
2781:
2777:
2770:
2762:
2758:
2754:
2750:
2745:
2740:
2736:
2732:
2728:
2721:
2710:
2706:
2699:
2693:
2691:
2682:
2675:
2659:
2655:
2648:
2642:
2640:
2638:
2636:
2627:
2623:
2619:
2615:
2611:
2604:
2596:
2592:
2588:
2584:
2577:
2569:
2565:
2560:
2555:
2550:
2545:
2541:
2537:
2533:
2526:
2518:
2514:
2509:
2504:
2500:
2496:
2492:
2488:
2484:
2477:
2468:
2464:
2460:
2455:
2450:
2446:
2442:
2438:
2434:
2430:
2423:
2415:
2411:
2406:
2401:
2397:
2393:
2389:
2385:
2381:
2374:
2372:
2363:
2359:
2354:
2349:
2345:
2341:
2337:
2333:
2329:
2322:
2314:
2310:
2305:
2300:
2296:
2292:
2288:
2284:
2280:
2273:
2265:
2261:
2257:
2253:
2248:
2243:
2239:
2235:
2228:
2220:
2216:
2212:
2208:
2204:
2200:
2196:
2192:
2184:
2176:
2170:
2165:
2164:
2155:
2147:
2141:
2137:
2130:
2128:
2126:
2124:
2108:
2104:
2098:
2082:
2078:
2074:
2068:
2059:
2054:
2050:
2046:
2040:
2031:
2026:
2022:
2018:
2012:
2004:
2002:9783527607495
1998:
1994:
1993:
1985:
1978:
1966:
1962:
1956:
1948:
1946:9781284057560
1942:
1938:
1931:
1915:
1911:
1907:
1901:
1893:
1889:
1885:
1881:
1877:
1873:
1866:
1850:
1846:
1840:
1838:
1836:
1834:
1832:
1830:
1828:
1826:
1824:
1822:
1813:
1809:
1804:
1799:
1795:
1791:
1787:
1786:
1778:
1776:
1759:
1752:
1736:
1732:
1728:
1722:
1720:
1718:
1716:
1699:
1698:
1697:Health Canada
1693:
1692:"Skin health"
1687:
1671:
1667:
1663:
1657:
1655:
1653:
1648:
1632:
1628:
1620:
1607:
1603:
1601:
1597:
1592:
1590:
1586:
1582:
1578:
1575:
1571:
1567:
1563:
1562:
1557:
1553:
1549:
1539:
1537:
1533:
1529:
1525:
1517:
1513:
1512:
1511:
1509:
1499:
1481:
1476:
1472:
1459:
1456:
1454:
1451:
1449:
1446:
1443:
1440:
1437:
1434:
1433:
1432:
1430:
1422:
1415:
1406:
1404:
1393:
1391:
1387:
1383:
1380:
1376:
1372:
1368:
1359:
1352:
1347:
1338:
1330:
1328:
1327:neurotoxicity
1324:
1320:
1318:
1314:
1312:
1308:
1306:
1297:
1295:
1290:
1280:
1278:
1273:
1270:
1265:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1215:
1211:
1207:
1203:
1188:
1184:
1182:
1177:
1174:
1173:organogenesis
1169:
1160:
1158:
1157:cotrimoxazole
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1128:
1124:
1119:
1117:
1112:
1108:
1104:
1096:
1093:
1089:
1086:
1083:
1082:mucocutaneous
1079:
1077:
1074:
1072:
1069:
1065:
1061:
1059:
1056:
1053:
1049:
1047:
1044:
1041:
1037:
1033:
1032:
1031:
1029:
1025:
1016:
1007:
1001:
997:
993:
988:
986:
982:
978:
974:
973:breastfeeding
970:
966:
965:low platelets
961:
959:
955:
951:
947:
943:
939:
935:
931:
927:
917:
910:
901:
896:
895:
892:
885:
876:
875:
872:
865:
861:
859:
858:Melting point
855:
848:
844:
843:
841:
838:
833:
826:
824:
820:
793:
791:
787:
782:
778:
774:
771:
769:
767:ECHA InfoCard
763:
755:
751:
750:DTXSID1022556
747:
746:
744:
735:
731:
723:
722:RCSB PDB
717:
712:
711:
709:
707:
703:
696:
692:
691:
689:
687:
683:
676:
672:
671:
669:
667:
663:
656:
652:
649:
645:
644:
642:
640:
636:
629:
625:
624:
622:
620:
616:
609:
605:
604:
602:
600:
596:
589:
585:
584:
582:
580:
576:
569:
565:
564:
562:
560:
556:
549:
545:
544:
542:
535:PubChem
533:
526:
522:
521:
519:
512:
508:
501:
497:
496:
494:
492:
488:
480:
475:
474:
471:
464:
459:
455:
452:
450:
446:
442:
440:
433:
430:
427:
425:
421:
417:
415:
411:
407:
405:
401:
397:
393:
387:
377:
374:
364:
362:
353:
350:
340:
339:
337:
335:
331:
326:
318:
313:
308:
303:
298:
293:
288:
283:
280:
279:
277:
275:
271:
268:
264:
260:
256:
253:
251:
245:
239:
230:
229:
227:
225:
219:
212:
207:
198:
197:
195:
193:
189:
185:
181:
179:
175:
168:
163:
160:
155:
154:
152:
150:
146:
142:
133:
124:
120:
116:
112:
110:
106:
100:
65:
63:Pronunciation
61:
58:Clinical data
56:
52:
47:
43:
38:
30:
19:
6155:Nephrotoxins
6088:
6064:Side Effects
6062:
6034:
6027:
6020:
6013:
6006:
5982:Andrew Witty
5967:Mahlon Kline
5918:Vivienne Cox
5731:
5687:H5N1 vaccine
5614:
5448:acquisitions
5386:Subsidiaries
5312:Polihexanide
5266:Tosufloxacin
5251:Moxifloxacin
5246:Lomefloxacin
5236:Levofloxacin
5231:Gatifloxacin
5221:Besifloxacin
5198:Trifluridine
5167:
5140:Sulfafenazol
5122:Sulfonamides
5112:Fusidic acid
5091:polypeptides
5089:
5074:beta-lactams
5072:
5062:Erythromycin
5055:
5050:Micronomicin
5003:
4988:Tetracycline
4981:
4964:
4843:Filociclovir
4755:
4718:
4666:
4614:Tromantadine
4601:
4534:
4508:
4491:Trifluridine
4479:
4454:
4429:Valaciclovir
4424:
4418:
4304:Tirbanibulin
4258:Tromantadine
4217:
4167:Sulfonamides
4129:Fusidic acid
4125:
4097:Nadifloxacin
4045:Tetracycline
4021:Tetracycline
3942:Pharmacology
3941:
3924:
3920:
3901:
3882:
3847:
3843:
3816:. Retrieved
3805:
3796:
3774:. Retrieved
3761:
3752:
3740:. Retrieved
3735:
3726:
3712:
3703:
3699:
3693:
3674:
3629:
3625:
3615:
3590:
3586:
3580:
3555:
3551:
3545:
3536:
3530:
3493:
3487:
3468:
3443:
3439:
3421:
3412:
3393:
3389:
3379:
3352:
3348:
3338:
3303:
3299:
3289:
3254:
3250:
3240:
3228:. Retrieved
3223:
3213:
3201:. Retrieved
3192:
3183:
3171:. Retrieved
3162:
3153:
3142:. Retrieved
3138:
3129:
3110:
3104:
3079:
3075:
3069:
3060:
3025:
3021:
3011:
2978:
2974:
2968:
2943:
2939:
2933:
2906:
2902:
2892:
2867:
2863:
2853:
2828:
2824:
2818:
2783:
2779:
2769:
2734:
2730:
2720:
2709:the original
2704:
2680:
2674:
2662:. Retrieved
2653:
2617:
2613:
2603:
2586:
2582:
2576:
2539:
2535:
2525:
2490:
2486:
2476:
2436:
2432:
2422:
2387:
2383:
2335:
2331:
2321:
2286:
2282:
2272:
2237:
2233:
2227:
2194:
2190:
2183:
2162:
2154:
2135:
2110:. Retrieved
2106:
2097:
2085:. Retrieved
2076:
2067:
2058:10665/345533
2048:
2039:
2030:10665/325771
2020:
2011:
1991:
1984:
1976:
1969:. Retrieved
1955:
1936:
1930:
1918:. Retrieved
1909:
1900:
1875:
1871:
1865:
1853:. Retrieved
1783:
1762:. Retrieved
1751:
1739:. Retrieved
1730:
1702:. Retrieved
1700:. 9 May 2018
1695:
1686:
1674:. Retrieved
1665:
1631:
1618:
1604:
1600:valaciclovir
1593:
1566:Robert Vince
1559:
1548:cytotoxicity
1545:
1536:nitrous acid
1521:
1505:
1498:of 3 hours.
1468:
1426:
1409:Microbiology
1399:
1364:
1336:
1321:
1315:
1309:
1305:Ketoconazole
1303:
1286:
1274:
1266:
1234:crystalluria
1199:
1185:
1178:
1170:
1166:
1131:
1120:
1116:side effects
1111:Valaciclovir
1100:
1021:
989:
979:that mimics
962:
940:infections,
929:
925:
924:
913:
481:-purin-6-one
478:
436:Elimination
334:Legal status
328:Legal status
267:eye ointment
192:License data
29:
5931:Judy Lewent
5322:Propamidine
5307:Picloxydine
5282:Bibrocathol
5256:Norfloxacin
5188:Idoxuridine
5183:Ganciclovir
5173:Famciclovir
5101:Tyrothricin
5096:Polymyxin B
4966:amphenicols
4957:Antibiotics
4882:from market
4852:Taribavirin
4744:Telbivudine
4710:Hepatitis B
4696:Tecovirimat
4691:Methisazone
4486:Idoxuridine
4447:Famciclovir
4443:Penciclovir
4434:Ganciclovir
4383:Herpesvirus
4374:Baltimore I
4355:(primarily
4273:Ibacitabine
4228:Idoxuridine
4223:Penciclovir
4139:Tyrothricin
4012:Antibiotics
3991:Antibiotics
3818:12 December
3776:13 December
3396:(1): 1–12.
3220:"Aciclovir"
2471:– Editorial
2439:(7022): 6.
1845:"Acyclovir"
1676:6 September
1662:"Aciclovir"
1552:Nucleosides
1532:amino group
1475:intravenous
1429:herpesvirus
1420:MRC-5 cells
1258:anaphylaxis
1240:, fatigue,
1226:neutropenia
1133:Intravenous
1129:eye drops.
1123:idoxuridine
1092:blepharitis
1010:Medical use
830: g·mol
773:100.056.059
461:Identifiers
255:Intravenous
178:MedlinePlus
118:Other names
109:Trade names
6139:Categories
6000:Litigation
5987:Chris Gent
5936:Urs Rohner
5844:Parodontax
5652:Engerix-B
5465:Block Drug
5327:Resorcinol
5302:Nitrofural
5297:Hexamidine
5203:Vidarabine
5193:Interferon
5178:Fomivirsen
5160:Antivirals
5079:Ampicillin
5057:macrolides
5045:Netilmicin
5040:Gentamicin
5035:Tobramycin
5020:Framycetin
4857:Moroxydine
4814:Interferon
4734:Lamivudine
4683:Poxviridae
4673:Rifampicin
4644:Resiquimod
4608:Fomivirsen
4592:Letermovir
4582:Amenamevir
4541:Cytarabine
4526:Sorivudine
4495:+tipiracil
4461:Vidarabine
4353:antivirals
4243:Resiquimod
4210:Antivirals
4134:Bacitracin
4093:Quinolones
4081:Gentamicin
4061:Amphenicol
3706:: 127–134.
3700:Chemtracts
3680:US 4146715
3230:6 February
3203:5 February
3173:5 February
3144:2019-08-02
3082:(9): 547.
2731:Pediatrics
2664:6 February
2112:14 January
2087:14 January
1756:Kevin ES.
1741:5 February
1643:References
1594:A related
1396:Resistance
1323:Zidovudine
1317:Interferon
1311:Probenecid
1230:leukopenia
1222:arthralgia
1137:chickenpox
1064:chickenpox
1052:cold sores
1040:prevention
1026:(HSV) and
942:chickenpox
835:3D model (
823:Molar mass
706:PDB ligand
675:CHEBI:2453
628:X4HES1O11F
599:ChemSpider
559:IUPHAR/BPS
500:59277-89-3
491:CAS Number
470:IUPAC name
424:Metabolism
156:Acyclovir
6070:Study 329
5881:Directors
5879:Board of
5854:Sensodyne
5834:Nicorette
5791:Emergen-C
5786:ChapStick
5766:BC Powder
5761:Aquafresh
5702:Pandemrix
5672:Hepatyrix
5570:Flixonase
5550:Augmentin
5261:Ofloxacin
5168:Aciclovir
5107:Rifamycin
5067:Natamycin
5025:Kanamycin
4892:Phase III
4880:Withdrawn
4848:Ribavirin
4799:Cidofovir
4749:Clevudine
4739:Lobucavir
4729:Entecavir
4640:Imiquimod
4597:Maribavir
4587:Docosanol
4562:Foscarnet
4516:Brivudine
4501:Edoxudine
4425:Aciclovir
4403:activated
4393:inhibitor
4350:DNA virus
4253:Docosanol
4238:Imiquimod
4233:Edoxudine
4218:Aciclovir
4144:Mupirocin
4119:Rifaximin
4115:Rifamycin
3736:Drugs.com
3330:240858022
2242:CiteSeerX
1733:. WebMD.
1666:Drugs.com
1528:alkylated
1502:Chemistry
1351:guanosine
1242:hepatitis
1181:varicella
1163:Pregnancy
1127:brivudine
981:guanosine
969:pregnancy
930:acyclovir
926:Aciclovir
695:ChEMBL184
449:Excretion
443:2–4 hours
438:half-life
248:Routes of
222:Pregnancy
211:Acyclovir
167:Monograph
159:Monograph
149:Drugs.com
34:Aciclovir
18:Acyclovir
6117:Medicine
6089:Category
5839:NiQuitin
5829:Nicoderm
5824:Lucozade
5819:Horlicks
5801:Excedrin
5776:Caltrate
5722:Shingrix
5712:Rabavert
5707:Pediarix
5682:Infanrix
5662:FluLaval
5647:Cervarix
5642:Boostrix
5625:Vaccines
5600:Ventolin
5590:Serlipet
5580:Lamictal
5575:Hycamtin
5560:Beconase
5519:Products
5030:Amikacin
5015:Neomycin
4766:Adefovir
4668:assembly
4659:Vaccinia
4536:cytosine
4268:Lysozyme
4185:Mafenide
4086:Amikacin
4076:Neomycin
3874:20684612
3812:Archived
3807:DailyMed
3770:Archived
3742:17 March
3607:19149592
3572:84041855
3522:75449475
3281:21078929
3197:Archived
3167:Archived
3163:DailyMed
3003:32983100
2995:24942005
2960:25440915
2925:12748346
2810:21964179
2753:15687461
2658:Archived
2626:19357635
2595:15767977
2568:20519025
2517:12069980
2467:Archived
2414:25879115
2362:24500927
2353:10583132
2313:27933614
2264:16006448
2211:20544224
2107:ClinCalc
2081:Archived
2077:ClinCalc
2047:(2021).
2019:(2019).
1965:Archived
1920:22 April
1914:Archived
1892:20739216
1849:Archived
1812:16284630
1735:Archived
1704:13 April
1670:Archived
1581:abacavir
1289:erythema
1238:anorexia
1071:patients
1058:Shingles
1034:Genital
958:injected
946:shingles
932:, is an
916:(verify)
579:DrugBank
548:46506002
274:ATC code
259:by mouth
237: B3
224:category
206:DailyMed
6160:Purines
6129:Viruses
6103:Portals
5809:Geritol
5805:Flonase
5781:Centrum
5771:Biotene
5753:Actifed
5727:Twinrix
5717:Rotarix
5677:Hiberix
5657:Fluarix
5637:Bexsero
5595:Tagamet
5555:Avandia
5526:Current
5393:Current
4510:thymine
4481:uridine
4456:adenine
4420:guanine
4359:, also
4263:Inosine
3865:2936711
3634:Bibcode
3460:5553754
3371:7510619
3322:2653790
3272:3028810
3096:3468354
3052:3021048
2884:3376977
2845:6285711
2801:3184032
2761:5791615
2559:2880255
2463:8555890
2454:2349724
2405:4443501
2304:6463965
2219:2969472
1971:8 March
1803:1615839
1596:prodrug
1542:History
1371:kinases
1214:vertigo
1200:Common
828:225.208
790:Formula
588:DB00787
511:PubChem
359::
314: (
312:D06BB53
304: (
302:S01AD03
294: (
292:D06BB03
290:)
284: (
282:J05AB01
263:topical
208::
184:a681045
5872:People
5849:Ribena
5746:Former
5697:Menveo
5692:Kinrix
5667:Havrix
5632:Arexvy
5610:Zantac
5565:Boniva
5540:Advair
5533:Pharma
5435:Haleon
5430:Former
5415:Tesaro
4875:WHO-EM
4761:NtRTIs
4724:NARTIs
4521:FV-100
4278:Lysine
4126:other:
4054:Others
3948:
3908:
3889:
3872:
3862:
3686:
3666:202961
3664:
3657:431864
3654:
3605:
3570:
3520:
3510:
3480:
3458:
3369:
3328:
3320:
3279:
3269:
3117:
3094:
3050:
3043:180521
3040:
3001:
2993:
2958:
2923:
2882:
2843:
2808:
2798:
2759:
2751:
2624:
2593:
2566:
2556:
2515:
2508:127288
2505:
2461:
2451:
2412:
2402:
2360:
2350:
2311:
2301:
2262:
2244:
2217:
2209:
2171:
2142:
1999:
1943:
1890:
1855:Jan 1,
1810:
1800:
1764:25 May
1598:form,
1556:sponge
1524:purine
1260:, and
1218:oedema
1080:Acute
1062:Acute
1004:
944:, and
871:SMILES
686:ChEMBL
655:C06810
648:D00222
454:Kidney
386:℞-only
384:
371:
361:℞-only
347:
204:
103:
6046:Other
5950:Other
5757:Advil
5475:Glaxo
5422:(85%)
5275:Other
4712:(VII)
4575:Other
4365:D06BB
4361:S01AD
4287:Other
4001:use (
3766:(FDA)
3762:U.S.
3568:S2CID
3518:S2CID
3349:Drugs
3326:S2CID
3300:Drugs
2999:S2CID
2757:S2CID
2712:(PDF)
2701:(PDF)
2650:(PDF)
2215:S2CID
1623:Notes
1615:Names
1583:, an
1379:viral
891:InChI
837:JSmol
713:AC2 (
666:ChEBI
429:Liver
418:9–33%
5859:Tums
5732:more
5615:more
5545:Alli
4948:S01A
4363:and
3997:for
3993:and
3946:ISBN
3906:ISBN
3887:ISBN
3870:PMID
3820:2019
3778:2019
3744:2019
3662:PMID
3603:PMID
3508:ISBN
3456:PMID
3367:PMID
3318:PMID
3277:PMID
3232:2014
3205:2014
3175:2014
3115:ISBN
3092:PMID
3048:PMID
2991:PMID
2956:PMID
2921:PMID
2880:PMID
2841:PMID
2806:PMID
2749:PMID
2666:2014
2622:PMID
2591:PMID
2564:PMID
2513:PMID
2459:PMID
2410:PMID
2358:PMID
2336:2014
2309:PMID
2287:2016
2260:PMID
2207:PMID
2169:ISBN
2140:ISBN
2114:2024
2089:2024
1997:ISBN
1973:2016
1941:ISBN
1922:2014
1888:PMID
1857:2015
1808:PMID
1766:2017
1743:2014
1706:2024
1678:2015
1585:nRTI
1526:was
1139:and
716:PDBe
639:KEGG
619:UNII
608:1945
568:4829
525:2022
398:data
145:AHFS
132:USAN
5796:Eno
5379:GSK
4628:HPV
4357:J05
4003:D06
3929:doi
3860:PMC
3852:doi
3652:PMC
3642:doi
3595:doi
3560:doi
3498:doi
3448:doi
3398:doi
3357:doi
3308:doi
3267:PMC
3259:doi
3084:doi
3080:316
3038:PMC
3030:doi
2983:doi
2948:doi
2911:doi
2872:doi
2833:doi
2796:PMC
2788:doi
2739:doi
2735:115
2705:GSK
2554:PMC
2544:doi
2503:PMC
2495:doi
2449:PMC
2441:doi
2437:312
2433:BMJ
2400:PMC
2392:doi
2348:PMC
2340:doi
2299:PMC
2291:doi
2252:doi
2199:doi
2053:hdl
2025:hdl
1880:doi
1798:PMC
1790:doi
1496:1/2
1492:1/2
1488:1/2
1484:1/2
1375:GTP
1256:,
1149:HIV
1066:in
985:DNA
739:EPA
538:SID
515:CID
373:POM
317:WHO
310:),
307:WHO
300:),
297:WHO
287:WHO
123:BAN
96:ɪər
6141::
5729:…
5612:…
4942::
4888::
4632:MC
4401:TK
4117::
4106::
4095::
4074::
4063::
3925:11
3923:.
3868:.
3858:.
3848:53
3846:.
3842:.
3804:.
3760:.
3734:.
3704:21
3702:.
3660:.
3650:.
3640:.
3630:74
3628:.
3624:.
3601:.
3591:10
3589:.
3566:.
3556:19
3554:.
3516:.
3506:.
3454:.
3444:14
3442:.
3430:^
3420:.
3394:18
3392:.
3388:.
3365:.
3353:47
3351:.
3347:.
3324:.
3316:.
3304:37
3302:.
3298:.
3275:.
3265:.
3255:55
3253:.
3249:.
3222:.
3191:.
3161:.
3137:.
3090:.
3078:.
3046:.
3036:.
3026:30
3024:.
3020:.
2997:.
2989:.
2979:23
2977:.
2954:.
2944:61
2942:.
2919:.
2907:18
2905:.
2901:.
2878:.
2868:84
2866:.
2862:.
2839:.
2829:73
2827:.
2804:.
2794:.
2784:86
2782:.
2778:.
2755:.
2747:.
2733:.
2729:.
2703:.
2689:^
2652:.
2634:^
2618:58
2616:.
2612:.
2585:.
2562:.
2552:.
2540:13
2538:.
2534:.
2511:.
2501:.
2491:46
2489:.
2485:.
2465:.
2457:.
2447:.
2435:.
2431:.
2408:.
2398:.
2386:.
2382:.
2370:^
2356:.
2346:.
2334:.
2330:.
2307:.
2297:.
2285:.
2281:.
2258:.
2250:.
2238:56
2236:.
2213:.
2205:.
2195:18
2193:.
2122:^
2105:.
2079:.
2075:.
1975:.
1908:.
1886:.
1876:49
1874:.
1820:^
1806:.
1796:.
1774:^
1729:.
1714:^
1694:.
1668:.
1664:.
1651:^
1558:,
1510:.
1482:(t
1392:.
1264:.
1252:,
1248:,
1244:,
1236:,
1232:,
1228:,
1220:,
1118:.
987:.
960:.
804:11
719:,
380:US
367:UK
356:CA
349:S4
343:AU
265:,
261:,
257:,
233:AU
201:US
136:US
127:UK
90:oʊ
81:aɪ
72:eɪ
6105::
5371:e
5364:t
5357:v
5242:)
5238:(
5103:)
5094:(
5086:)
5077:(
5069:)
5060:(
5052:)
5008:(
5000:)
4986:(
4978:)
4969:(
4950:)
4946:(
4932:e
4925:t
4918:v
4850:/
4763::
4759:/
4726::
4722:/
4670::
4642:/
4630:/
4610:)
4606:(
4543:)
4539:(
4503:)
4497:)
4493:(
4484:(
4463:)
4459:(
4449:)
4445:/
4436:/
4427:/
4423:(
4367:)
4342:e
4335:t
4328:v
4005:)
3983:e
3976:t
3969:v
3954:.
3935:.
3931::
3914:.
3895:.
3876:.
3854::
3822:.
3791:.
3780:.
3746:.
3720:.
3668:.
3644::
3636::
3609:.
3597::
3574:.
3562::
3524:.
3500::
3462:.
3450::
3424:.
3406:.
3400::
3373:.
3359::
3332:.
3310::
3283:.
3261::
3234:.
3207:.
3177:.
3147:.
3123:.
3098:.
3086::
3054:.
3032::
3005:.
2985::
2962:.
2950::
2927:.
2913::
2886:.
2874::
2847:.
2835::
2812:.
2790::
2763:.
2741::
2668:.
2628:.
2597:.
2587:3
2570:.
2546::
2519:.
2497::
2443::
2416:.
2394::
2388:1
2364:.
2342::
2315:.
2293::
2266:.
2254::
2221:.
2201::
2177:.
2148:.
2116:.
2091:.
2055::
2027::
2005:.
1949:.
1924:.
1894:.
1882::
1859:.
1814:.
1792::
1768:.
1745:.
1708:.
1680:.
1054:)
1042:)
839:)
816:3
813:O
810:5
807:N
801:H
798:8
795:C
741:)
737:(
725:)
479:H
382::
369::
345::
320:)
235::
147:/
139:)
99:/
93:v
87:l
84:k
78:s
75:ˈ
69:/
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
