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Access to COVID-19 Tools Accelerator

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42: 1616: 1725:, production, and globally-equitable access to COVID-19 tests, therapies, and vaccines. It is a framework for collaboration, not a new organization or a decision-making body. In March 2020, G20 leaders had called for a cross-discipline support structure to enable partners to share resources and knowledge and in April 2020 it was launched by WHO, European Commission, France and the Bill & Melinda Gates Foundation. On 24 April 2020 pro-tem Chair 1865:. The manufacturers of three vaccines closest to global distribution – Pfizer, Moderna, and AstraZeneca – predicted a manufacturing capacity of 5.3 billion doses in 2021, which could be used to vaccinate about 3 billion people (as the vaccines require two doses for a protective effect against COVID-19). Due to the high demand in preorders from rich countries for 2021, people in low-income 1818:(GLoPID-R) which was working closely with the WHO and member states to identify priorities for funding specific research needed for a COVID-19 vaccine, coordinating among the international funding and research organizations to maintain updated information on vaccine progress and avoid duplicate funding. 1885:
in many countries focusing on a COVID-19 vaccine. According to CEPI, the general geographic distribution of COVID-19 vaccine development involves organizations in North America having about 40% of the world's COVID-19 vaccine research, compared with 30% in Asia and Australia, 26% in Europe, and a few
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The ACT Accelerator comprises four pillars, each managed by two to three collaborating partners:1) Vaccines (also called "COVAX" pillar), 2) Diagnostics, 3) Therapeutics and 4) Health Systems Connector. Diagnostics are the most important medical technology available to monitor and control the spread
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The COVAX administration, governments, and vaccine manufacturers have been criticized for lack of transparency and accountability over fair pricing and equitable allocation of COVID-19 vaccines to developing countries where financial and vaccination resources are limited, and government corruption
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billion fund in a global partnership between public, private, philanthropic, and civil society organizations for accelerated research and clinical testing of nine COVID-19 vaccine candidates, with the 2020–21 goal of supporting several candidate vaccines for full development to licensing. By early
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Over 2020 throughout the pandemic, CEPI funded the development of nine COVID-19 vaccine candidates in a portfolio deliberately made diverse across different vaccine technologies to minimize the typically high risk of failure inherent in vaccine development. As of December 2020, CEPI supported the
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In examining the founding principles of participation, transparency, and accountability, one study found lacking clarity on the roles and responsibilities of the stakeholders, questions about potential conflicts of interest, unclear accountability with no ACT-A wide accountability framework and
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analyzes needs and resources in some 100 countries to identify problems, capacity, and requirements for access to and implementation of COVID-19 tools across world regions. The COVAX pillar has the goal of facilitating licensure of several COVID-19 vaccines, influencing equitable pricing, and
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doses, 245 million treatments, and 500 million tests that the initiative deemed necessary to end the pandemic and speed economic global recovery. In September 2020, ACT Accelerator partners committed to provide 120 million COVID-19 rapid tests for low- and middle-income countries.
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may not receive vaccinations from these manufacturers until 2023 or 2024, increasing the use of the COVAX initiative to supply vaccines equitably. Emphasizing the need for broad distribution of safe, effective vaccines against COVID-19, especially across developing countries,
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COVAX is designed to assist vaccine purchases and distribution for poor and middle-income countries unable to compete in the open market and avoid inequities for vaccine access. However, by December 2020, more than 10 billion vaccine doses had been preordered mostly by
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Moon, Suerie; Armstrong, Jana; Hutler, Brian; Upshur, Ross; Katz, Rachel; Atuire, Caesar; Bhan, Anant; Emanuel, Ezekiel; Faden, Ruth; Ghimire, Prakash; Greco, Dirceu; Ho, Calvin WL; Kochhar, Sonali; Schaefer, G Owen; Shamsi-Gooshki, Ehsan (11 December 2021).
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of COVID-19, to avoid repeated lockdowns, which threaten economies and ways of life. Testing supports healthcare services to be managed and COVID-19 transmission to be suppressed. The therapeutics pillar is a research effort to discover and develop promising
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billion had been raised for the overall ACT Accelerator, with nine vaccine candidates being funded by COVAX and CEPI – the world's largest COVID-19 vaccine portfolio – with 189 countries committed to the eventual deployment plan. See table above.
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GloPID-R Members and other major players involved in infectious disease outbreaks worldwide reacted rapidly to this emerging epidemic, working closely with WHO to identify the specific funding research priorities needed to tackle the
2059:, had difficulty obtaining vaccine deliveries, despite having a factory for making COVID-19 vaccines within the country. Half of South African citizens live in poverty, and may receive a vaccine only by participating as volunteers in 3268:"Global equitable access to COVID-19 vaccines estimated to generate economic benefits of at least US$ 153 billion in 2020–21, and US$ 466 billion by 2025, in 10 major economies, according to new report by the Eurasia Group" 1833:
On 10 September 2020 the UN and the European Union co-hosted the inaugural meeting of the Facilitation Council of the ACT-Accelerator, which had received $ 2.7 billion of the $ 35 billion necessary to secure the 2 billion
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million to the ACT Accelerator to "support the delivery of new COVID-19 tests, treatments, and vaccines, particularly in low- and middle-income countries" during 2021, making the Foundation's total donation of
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providing equal access for up to 2 billion doses by the end of 2021 to protect frontline healthcare workers and people with high-risk of COVID-19 infection, particularly in low-to-middle income countries.
41: 3337: 3241: 3422: 1218: 3399: 3267: 1254: 1208: 1815: 1577: 1126: 703: 688: 1213: 1274: 2140:; Armstrong, Jana; Hutler, Brian; Upshur, Ross; Katz, Rachel; Atuire, Caesar; Bhan, Anant; Emanuel, Ezekiel; Faden, Ruth; Ghimire, Prakash; Greco, Dirceu (29 January 2022). 1279: 3193: 1597: 1461: 1424: 2305: 3360: 1602: 1414: 683: 2037:
announced it would provide five Southeast Asian countries of Cambodia, Laos, Myanmar, Thailand and Vietnam priority access to the vaccine once it was fully developed.
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million by May. Belgium, Norway, Switzerland, Germany, and the Netherlands have been major contributors to the CEPI effort for COVID-19 vaccine research in Europe.
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On 22 July 2020, China announced that it planned to provide a US$ 1 billion loan to make its vaccine accessible for countries in Latin America and the
1419: 1328: 1259: 1168: 809: 799: 794: 715: 506: 355: 204: 3242:"Bill and Melinda Gates call for collaboration, continued innovation to overcome challenges of delivering COVID-19 scientific breakthroughs to the world" 1644: 1501: 1434: 764: 754: 501: 422: 391: 379: 350: 271: 240: 228: 199: 120: 3293: 3095:
3 trials, completion of regulatory and quality requirements for at least three vaccines, and enhancing global manufacturing capacity for three vaccines.
1582: 1441: 1269: 1244: 774: 769: 644: 530: 525: 518: 417: 410: 386: 374: 367: 266: 259: 235: 223: 216: 115: 108: 3333: 3121: 1249: 804: 513: 494: 405: 362: 343: 254: 211: 192: 103: 1592: 1548: 1308: 1163: 816: 749: 698: 489: 446: 434: 338: 295: 283: 187: 144: 132: 2096: 1767: 1694: 1538: 1481: 1399: 1343: 1323: 1146: 924: 482: 470: 441: 429: 331: 319: 290: 278: 180: 168: 139: 127: 3216: 3391: 936: 477: 465: 458: 326: 314: 307: 175: 163: 156: 1338: 1333: 1303: 1203: 1178: 919: 453: 302: 151: 1677:(WHO) on 24 April. As of January 2022, it was the largest international effort to achieve equitable access to COVID-19 health technologies. 1198: 2545: 2031: 1770:, CEPI was formed. It is working with international health authorities and vaccine developers to create vaccines for preventing epidemics. 1476: 1446: 1429: 1318: 634: 1663:
Global Collaboration to Accelerate the Development, Production and Equitable Access to New COVID-19 diagnostics, therapeutics and vaccines
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During 2020, major changes in the overall effort of developing COVID-19 vaccines were the increasing number of collaborations of the
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had withdrawn its financial support of the WHO and ACT Accelerator in 2020, the United States reasserted its support of the WHO and
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comprising only 14% of the world's population like the United Kingdom, Canada, and the United States. poorer countries, such as
2471: 1382: 671: 3186:"Bill Gates thinks there are 8 to 10 promising coronavirus vaccine candidates and one could be ready in as little as 9 months" 2244: 2581: 1745:
for COVID-19 infection and illness. It involves monitoring over 1,700 clinical trials, and was part of the effort to provide
1543: 1496: 988: 873: 3311: 3008: 1394: 693: 3294:"Over US$ 2 billion raised to support equitable access to COVID vaccines with additional US$ 5 billion needed in 2021" 2920: 3522: 2653: 2365: 1630: 892: 868: 594: 584: 2895: 2763:"How COVID vaccines are being divvied up around the world Canada leads the pack in terms of doses secured per capita" 2606:"Governing the Access to COVID-19 Tools Accelerator: towards greater participation, transparency, and accountability" 2142:"Governing the Access to COVID-19 Tools Accelerator: towards greater participation, transparency, and accountability" 1451: 606: 84: 3144: 3076:
CEPI estimates that developing up to three vaccines in the next 12–18 months will require an investment of at least
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May 2020, the United Kingdom, Canada, Belgium, Norway, Switzerland, Germany and the Netherlands had already donated
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Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
1982: 1722: 1082: 1072: 1040: 1035: 1025: 978: 973: 963: 851: 73: 2306:"WHO Director-General's opening remarks at the launch of the Access to COVID-19 Tools Accelerator" 1924: 1878: 1375: 1077: 1062: 1030: 666: 68: 3087:
1 clinical trials of eight vaccine candidates, progression of up to six candidates through Phase
2537: 1067: 1011: 710: 3361:"'A global challenge': PM Trudeau commits $ 850 million to global fight against COVID-19" 2052: 1934:
million in support of CEPI for research and public educational support on COVID-19 vaccines.
1506: 1092: 931: 2516:"CEPI and SK bioscience extend collaboration to develop 'next generation' COVID-19 vaccine" 1811: 1779: 968: 914: 8: 3454:"Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis" 3392:"China's Xi announces $ 2B for coronavirus response as WHO faces calls for investigation" 3334:"CEPI collaborates with the Institut Pasteur in a consortium to develop COVID-19 vaccine" 2830:"Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis" 1750: 1734: 2571: 2291: 2236: 1882: 1749:
for up to 2.9 million patients in low-income countries and facilitates future access to
3488: 3453: 3149: 3062: 3035: 2986: 2864: 2829: 2786: 2630: 2605: 2174: 2141: 1866: 1726: 1670: 1119: 654: 649: 3052: 2713:"U.S. says it won't join WHO-linked effort to develop, distribute coronavirus vaccine" 2686:"Leaders pledge 'quantum leap' towards fully funding COVID-19 vaccines and treatments" 2621: 2334: 2157: 3493: 3475: 3423:"Mexico says China plans $ 1 billion loan to ease Latam access to virus vaccine" 3154: 3067: 2990: 2978: 2970: 2869: 2851: 2790: 2778: 2762: 2635: 2179: 2161: 1862: 33: 3217:"Bill and Melinda Gates Foundation announces $ 250 million COVID vaccine commitment" 3114:"Special Report: Countries, companies risk billions in race for coronavirus vaccine" 2269: 1969:
million investment in a COVID-19 vaccine research consortium via CEPI involving the
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billion for COVID-19 vaccines and preparedness. On 18 May 2020, China had pledged
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billion in pledges from forty countries to support rapid development of vaccines.
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By December 2020, more than 10 billion vaccine doses had been pre-ordered by
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billion to support overall efforts by the WHO for programs against COVID-19.
1754: 1746: 720: 2663: 3527: 3497: 3071: 2982: 2873: 2782: 2639: 2183: 2097:"G20 launches initiative for health tools needed to combat the coronavirus" 2056: 1830:
started the ACT Together Fund in order to raise money for the Accelerator.
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Yamey G, Schäferhoff M, Hatchett R, Pate M, Zhao F, McDade KK (May 2020).
2732:"U.S., staying in WHO, to join COVID vaccine push for poor nations: Fauci" 2137: 1775: 3389: 3310:. Coalition for Epidemic Preparedness Innovation (CEPI). 30 April 2020. 3214: 2366:"Investing in diagnostics to manage the course of the COVID-19 pandemic" 2034: 1737:
accepted to act as Special Envoys to the ACT Accelerator from the WHO.
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on 24 April 2020. A call to action was published simultaneously by the
1363: 958: 725: 60: 3470: 2846: 1985:, bringing CEPI's total investment in COVID-19 vaccine development to 2024: 1855: 1803: 1097: 948: 3143:
Sanger DE, Kirkpatrick DD, Zimmer C, Thomas K, Wee SL (2 May 2020).
2472:"Why we need a "portfolio approach" to COVID-19 vaccine development" 2070: 1895: 1881:
with national governments, and the diversity and growing number of
1714: 54: 3336:. Coalition for Epidemic Preparedness Innovations. 19 March 2020. 2449:"Our portfolio: partnerships to develop vaccines against COVID-19" 1761: 3215:
Haley Yamada; Jon Schlosberg; Seni Tienabeso (10 December 2020).
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Global Research Collaboration for Infectious Disease Preparedness
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Steenhuysen J, Eisler P, Martell A, Nebehay S (27 April 2020).
3111: 1974: 1791: 1706: 3145:"With Pressure Growing, Global Race for a Vaccine Intensifies" 2921:"Why is no one safe until everyone is safe during a pandemic?" 2812:"COVAX: Ensuring global equitable access to COVID-19 vaccines" 2397:. Coalition for Epidemic Preparedness Innovations (CEPI). 2020 1753:
therapies in low- and middle-income countries. The pillar for
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dedicated to vaccine research and distribution, was donating
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Yuliya Talmazan; Keir Simmons; Laura Saravia (18 May 2020).
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and governments, to raise financial support of accelerated
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uses the slogan, "No one is safe until everyone is safe."
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The ACT Accelerator is a multinational collaboration, and
2949:"Evolution of the COVID-19 vaccine development landscape" 2896:"For Covid-19 Vaccines, Some Are Too Rich — and Too Poor" 2602: 2136: 1666: 2947:
Le TT, Cramer JP, Chen R, Mayhew S (4 September 2020).
2335:"The ACT-Accelerator: frequently asked questions (FAQ)" 2221: 1937:
In December 2020, the Gates Foundation donated another
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The ACT-Accelerator was launched on 24 April 2020. The
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Rauhala, Emily; Abutaleb, Yasmeen (2 September 2020).
1957: 2419: 2006:
million to the WHO's live streaming effort to raise
2946: 2894:Matt Apuzzo; Selam Gebrekidan (28 December 2020). 2729: 2443: 2441: 2439: 2437: 1923:million to CEPI. The Gates Foundation, a private 3518:International responses to the COVID-19 pandemic 3509: 2071:Limited transparency of roles and accountability 2828:So, Anthony D; Woo, Joshua (15 December 2020). 2710: 2486: 2264: 2262: 1774:vaccine research organizations and programs of 1768:Coalition for Epidemic Preparedness Innovations 1762:Coalition for Epidemic Preparedness Innovations 1695:Coalition for Epidemic Preparedness Innovations 2434: 3036:"Ensuring global access to COVID‑19 vaccines" 2760: 2414: 2412: 1729:announced it, simultaneously to the WHO. Sir 1638: 3009:"EU spearheads $ 8 billion virus fundraiser" 2469: 2463: 2259: 2114:"Access to COVID-19 Tools (ACT) Accelerator" 1999:May 2020, the Canadian government committed 1766:In 2017, a multinational organization named 40: 2360: 2358: 2356: 2231: 2229: 2095: 1810:(NVX-CoV2373), SK bioscience (GBP510), and 3308:"CEPI: Our vaccine and platform portfolio" 3208: 3107: 3105: 3103: 2756: 2754: 2752: 2409: 2387: 2329: 2327: 2325: 2323: 2321: 2319: 2108: 2106: 1645: 1631: 3487: 3469: 3300: 3234: 3061: 3051: 2964: 2942: 2940: 2938: 2913: 2889: 2887: 2885: 2883: 2863: 2845: 2629: 2173: 1844:Trump administration of the United States 1786:), Clover Biopharmaceuticals (SCB-2019), 3326: 3183: 3002: 3000: 2508: 2353: 2226: 2132: 2130: 3100: 2749: 2723: 2316: 2103: 2091: 2089: 1371:Neurological and psychological symptoms 3510: 3433:from the original on 25 September 2020 3358: 3352: 3260: 3136: 2935: 2880: 2530: 2247:from the original on 25 September 2020 1946:billion toward the COVID-19 response. 1886:projects in South America and Africa. 1669:initiative announced by pro-tem Chair 3451: 3083:billion. This estimate includes Phase 3027: 2997: 2827: 2823: 2821: 2730:Stephanie Nebehay (21 January 2021). 2584:from the original on 12 February 2023 2298: 2127: 1879:multinational pharmaceutical industry 3006: 2538:"GloPID: Novel coronavirus COVID-19" 2395:"COVAX: CEPI's response to COVID-19" 2086: 1659:Access to COVID-19 Tools Accelerator 3420: 3246:Bill & Melinda Gates Foundation 2494:"CEPI's COVID-19 vaccine portfolio" 1661:(ACT Accelerator or ACT-A), or the 13: 3445: 3340:from the original on 22 March 2020 2818: 2761:Asher Mullard (30 November 2020). 2470:Nick Jackson (28 September 2020). 1958:National governments contributions 14: 3539: 3015:from the original on 29 June 2020 1850:on 21 January 2021 following the 3402:from the original on 18 May 2020 3371:from the original on 10 May 2020 3196:from the original on 16 May 2020 3165:from the original on 11 May 2020 3124:from the original on 15 May 2020 2420:"New vaccines for a safer world" 2040: 1962:In May 2020, France announced a 1908:As of May 2020 CEPI organized a 1614: 3414: 3383: 3314:from the original on 7 May 2020 3286: 3177: 2804: 2704: 2678: 2646: 2596: 2564: 2548:from the original on 2 May 2020 3452:So AD, Woo J (December 2020). 2284: 2237:"What is the ACT Accelerator?" 2215: 2190: 2076:receding role of governments. 16:G20 COVID-19 global initiative 1: 3053:10.1016/S0140-6736(20)30763-7 2953:Nature Reviews Drug Discovery 2622:10.1016/S0140-6736(21)02344-8 2572:"What is the ACT Accelerator" 2292:"What is the ACT Accelerator" 2158:10.1016/S0140-6736(21)02344-8 2079: 2045: 1814:. CEPI is an observer of the 1680: 1889: 1395:Alzheimer's disease patients 920:Misinformation and hesitancy 7: 1894:In May 2020, the WHO had a 1821: 1687:multistakeholder initiative 10: 3544: 3184:Hamilton IA (1 May 2020). 2966:10.1038/d41573-020-00151-8 2775:10.1038/d41586-020-03370-6 3523:World Health Organization 3296:. Gavi. 13 November 2020. 3272:World Health Organization 2923:. GAVI. 14 September 2020 2659:United Nations Foundation 2577:World Health Organization 2373:World Health Organization 2339:World Health Organization 2310:World Health Organization 2241:World Health Organization 2222:GAVI the Vaccine Alliance 2121:World Health Organization 1828:United Nations Foundation 1743:COVID-19 drug development 1691:World Health Organization 1675:World Health Organization 704:World Health Organization 2814:. Gavi. 17 October 2022. 2272:. GAVI. 1 September 2020 1983:University of Pittsburgh 1723:research and development 874:Public health mitigation 558:By country and territory 3359:Aiello R (4 May 2020). 2518:. CEPI. 9 December 2020 1925:charitable organization 1883:biotechnology companies 1376:Post-exertional malaise 716:Undercounting of deaths 3421:Ore D (23 July 2020). 3274:(WHO). 4 December 2020 1790:(Zorecimeran/CVnCoV), 1701:the Vaccine Alliance, 1534:Science and technology 1410:Death rates by country 624:International response 46: 3221:ABC News - Technology 3007:Wake D (4 May 2020). 2312:(WHO). 24 April 2020. 2123:(WHO). 24 April 2020. 2053:high-income countries 1973:, Themis Bioscience ( 1949:As of December 2020, 1559:Xenophobia and racism 1425:Emergency evacuations 44: 1867:developing countries 1812:Hong Kong University 1780:University of Oxford 1294:Association football 915:Operation Warp Speed 2717:The Washington Post 2692:. 10 September 2020 2654:"ACT Together Fund" 2030:On 24 August 2020, 1863:developed countries 1856:President Joe Biden 1751:monoclonal antibody 1735:Ngozi Okonjo-Iweala 1492:Other health issues 1019:Variants of concern 3150:The New York Times 3046:(10234): 1405–06. 2900:The New York Times 2616:(10323): 487–494. 2152:(10323): 487–494. 1727:Mohammed al-Jadaan 1671:Mohammed al-Jadaan 984:Oxford–AstraZeneca 822:federal government 733:National responses 47: 3471:10.1136/bmj.m4750 3248:. 9 December 2020 3011:. Yahoo Finance. 2847:10.1136/bmj.m4750 2666:on 18 August 2021 2375:(WHO). 1 May 2020 1798:(MV-SARS-CoV-2), 1655: 1654: 1420:Domestic violence 1329:Gridiron football 1164:Financial markets 937:Vaccine passports 684:Social distancing 645:International aid 34:COVID-19 pandemic 3535: 3502: 3501: 3491: 3473: 3449: 3443: 3442: 3440: 3438: 3418: 3412: 3411: 3409: 3407: 3387: 3381: 3380: 3378: 3376: 3356: 3350: 3349: 3347: 3345: 3330: 3324: 3323: 3321: 3319: 3304: 3298: 3297: 3290: 3284: 3283: 3281: 3279: 3264: 3258: 3257: 3255: 3253: 3238: 3232: 3231: 3229: 3227: 3212: 3206: 3205: 3203: 3201: 3190:Business Insider 3181: 3175: 3174: 3172: 3170: 3140: 3134: 3133: 3131: 3129: 3109: 3098: 3097: 3094: 3090: 3086: 3082: 3079: 3065: 3055: 3031: 3025: 3024: 3022: 3020: 3004: 2995: 2994: 2968: 2944: 2933: 2932: 2930: 2928: 2917: 2911: 2910: 2908: 2906: 2891: 2878: 2877: 2867: 2849: 2825: 2816: 2815: 2808: 2802: 2801: 2799: 2797: 2758: 2747: 2746: 2744: 2742: 2727: 2721: 2720: 2708: 2702: 2701: 2699: 2697: 2682: 2676: 2675: 2673: 2671: 2662:. Archived from 2650: 2644: 2643: 2633: 2600: 2594: 2593: 2591: 2589: 2568: 2562: 2561: 2555: 2553: 2534: 2528: 2527: 2525: 2523: 2512: 2506: 2505: 2503: 2501: 2490: 2484: 2483: 2481: 2479: 2467: 2461: 2460: 2458: 2456: 2445: 2432: 2431: 2429: 2427: 2416: 2407: 2406: 2404: 2402: 2391: 2385: 2384: 2382: 2380: 2370: 2362: 2351: 2350: 2348: 2346: 2331: 2314: 2313: 2302: 2296: 2295: 2288: 2282: 2281: 2279: 2277: 2270:"What is COVAX?" 2266: 2257: 2256: 2254: 2252: 2233: 2224: 2219: 2213: 2212: 2210: 2208: 2194: 2188: 2187: 2177: 2134: 2125: 2124: 2118: 2110: 2101: 2100: 2099:. 25 April 2020. 2093: 2019: 2016: 2012: 2009: 2005: 2002: 1998: 1991: 1988: 1971:Institut Pasteur 1968: 1965: 1952: 1945: 1940: 1933: 1930: 1922: 1919: 1914: 1911: 1904: 1901: 1836:COVID-19 vaccine 1796:Institut Pasteur 1647: 1640: 1633: 1619: 1618: 1127:Arts and culture 943:Current vaccines 869:Drug repurposing 864:Drug development 841:Medical response 21: 20: 3543: 3542: 3538: 3537: 3536: 3534: 3533: 3532: 3508: 3507: 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Index

a series
COVID-19 pandemic
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
COVID-19
SARS-CoV-2
Cases
Deaths
Timeline
2019
January
responses
February
responses
March
responses
April
responses
May
responses
June
responses
July
responses
August
responses
September
responses
October
responses
November

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

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