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A longstanding research interest of the Doyle group is the development of nickel-catalyzed C–C bond forming reactions that utilize unconventional cross-coupling electrophiles, such as epoxides, aziridines, imminium ions, and oxocarbenium ions. The group has developed and mechanistically interrogated
336:
The group has also been involved in the development of nucleophilic fluorination chemistry allowing the creation of pharmaceutically relevant molecules with sp-C-F and sp-C-F bonds. These methods have employed both transition metal and photoredox catalysis, and the group has developed new reagents
315:
In July 2008, Doyle was appointed as an assistant professor of chemistry at
Princeton University. She was promoted to the rank of associate professor with tenure in 2013, and to full Professor with an endowed chair, the A. Barton Hepburn Professor of Chemistry, in 2017. In 2021, she moved to the
333:'s group, the Doyle lab identified a new cross-coupling paradigm which allows the combination of photoredox and nickel catalysis. The Doyle lab has subsequently applied Nickel/photoredox catalysis to methodologies involving both unconventional and traditional cross-coupling electrophiles.
711:
Shields, Benjamin J.; Stevens, Jason; Li, Jun; Parasram, Marvin; Damani, Farhan; Martinez
Alvarado, Jesus I.; Janey, Jacob M.; Adams, Ryan P.; Doyle, Abigail G. (2021-02-03). "Bayyesian reaction optimization as a tool for chemical synthesis".
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340:
Recently, the Doyle group has worked in the area of data science-driven analysis of chemical reactions, including the implementation of machine learning algorithms to model and predict reaction outcome in organic chemistry.
365:
National
Fresenius Award (Phi Lamba Upsilon, 2014), Presidential Early Career Award for Scientists and Engineers (PECASE, 2014) BMS Unrestricted Grant in Synthetic Organic Chemistry (2016).
954:
763:Żurański, Andrzej M.; Martinez Alvarado, Jesus I.; Shields, Benjamin J.; Doyle, Abigail G. (2021-03-31). "Predicting Reaction Yields via Supervised Learning".
233:, where she holds the Saul Winstein Chair in Organic Chemistry. Her research focuses on the development of new chemical transformations in organic chemistry.
934:
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421:"Enantioselective Alkylations of Tributyltin Enolates Catalyzed by Cr(salen)Cl: Access to Enantiomerically Enriched All-Carbon Quaternary Centers"
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Zuo, Zhiwei; Ahneman, Derek T.; Chu, Lingling; Terrett, Jack A.; Doyle, Abigail G.; MacMillan, David W. C. (2014-07-25).
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new ligands and pre-catalysts for nickel, which have helped to enable these transformations. In collaboration with
919:
468:"Enantioselective Alkylation of Acyclic α,α-Disubstituted Tributyltin Enolates Catalyzed by a Cr(salen) Complex"
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Ahneman, Derek T.; Estrada, Jesus G. J.; Lin, Shishi; Dreher, Spencer D.; Doyle, Abigail G. (2018-02-15).
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Some key awards of Doyle's independent career include the Alfred P. Sloan
Foundation Fellowship (
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591:"Merging photoredox with nickel catalysis: Coupling of α-carboxyl sp3-carbons with aryl halides"
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837:"2014 Arthur C. Cope Scholar Awards: Abigail G. Doyle | Chemical & Engineering News"
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Recipients of the
Presidential Early Career Award for Scientists and Engineers
656:"Predicting reaction performance in C–N cross-coupling using machine learning"
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Reisman, Sarah E.; Doyle, Abigail G.; Jacobsen, Eric N. (2008-06-01).
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515:"Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions"
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Engaging alkyl halides and oxocarbenium ions in asymmetric catalysis
396:"Welcome Professor Abigail Doyle | UCLA Chemistry and Biochemistry"
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287:
320:, where she holds the Saul Winstein Chair in Organic Chemistry.
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After beginning graduate studies in the lab of Justin DuBois at
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861:"Abigail Doyle | Princeton University Department of Chemistry"
361:, 2014), Bayer Early Excellence in Science Award (2013),
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for mild and selective deoxyfluorination reactions.
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Harvard
Graduate School of Arts and Sciences alumni
419:Doyle, Abigail G.; Jacobsen, Eric N. (2005-01-01).
261:. Doyle studied chemistry as an undergraduate at
906:
353:, 2012), Amgen Young Investigator Award (2012),
466:Doyle, Abigail G.; Jacobsen, Eric N. (2007).
465:
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294:. She also worked on the development of an
241:Doyle was born in Princeton, NJ in 1980 to
236:
679:
630:
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935:American people of German-Jewish descent
519:Journal of the American Chemical Society
425:Journal of the American Chemical Society
393:
278:, Doyle completed her Ph.D. under Prof.
265:, graduating with A.B. and A.M. degrees
472:Angewandte Chemie International Edition
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318:University of California, Los Angeles
231:University of California, Los Angeles
143:University of California, Los Angeles
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259:United States Ambassador to Germany
229:is a professor of chemistry at the
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394:Jennings, Penny (Jun 30, 2021).
368:She is currently Senior Editor,
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765:Accounts of Chemical Research
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371:Accounts of Chemical Research
925:Princeton University faculty
777:10.1021/acs.accounts.0c00770
355:Arthur C. Cope Scholar Award
298:addition of nucleophiles to
183:Other academic advisors
104:Arthur C. Cope Scholar Award
7:
10:
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950:21st-century American Jews
940:Jewish American scientists
734:10.1038/s41586-021-03213-y
351:Alfred P. Sloan Foundation
255:University of Pennsylvania
359:American Chemical Society
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237:Early life and education
129:Organometallic chemistry
16:American organic chemist
865:chemistry.princeton.edu
681:10.1126/science.aar5169
615:10.1126/science.1255525
920:Harvard College alumni
579:, Princeton University
484:10.1002/anie.200604901
400:www.chemistry.ucla.edu
282:, where she developed
227:Abigail Gutmann Doyle
46:Princeton, New Jersey
292:Cr(salen)Cl catalyst
288:tributyltin enolates
147:Princeton University
108:Elias J. Corey Award
835:Ritter, Stephen K.
726:2021Natur.590...89S
672:2018Sci...360..186A
607:2014Sci...345..437Z
276:Stanford University
575:2017-11-14 at the
363:Phi Lambda Upsilon
311:Independent career
263:Harvard University
58:Harvard University
666:(6385): 186–190.
601:(6195): 437–440.
531:10.1021/ja801514m
525:(23): 7198–7199.
478:(20): 3701–3705.
437:10.1021/ja043601p
345:Awards and honors
300:oxocarbenium ions
286:alkylations with
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125:Organic Chemistry
115:Scientific career
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296:enantioselective
284:enantioselective
280:Eric N. Jacobsen
243:Michael W. Doyle
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193:Notable students
177:Eric N. Jacobsen
172:Doctoral advisor
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84:Michael W. Doyle
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892:. Retrieved
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257:and current
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139:Institutions
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945:1980 births
841:cen.acs.org
247:Amy Gutmann
197:Julia Kalow
90:Amy Gutmann
909:Categories
894:2018-09-02
870:2020-10-27
846:2018-09-02
821:2018-09-02
405:2021-07-01
378:References
35:1980-04-30
885:"Editors"
811:sloan.org
793:232483029
750:231804657
698:206666015
623:0036-8075
539:0002-7863
492:1521-3773
445:0002-7863
271:in 2002.
251:president
133:Catalysis
785:33788552
742:33536653
690:29449509
641:24903563
573:Archived
557:18479086
500:17407117
453:15631449
324:Research
92:(mother)
86:(father)
722:Bibcode
668:Bibcode
660:Science
632:4296524
603:Bibcode
595:Science
548:2574628
253:of the
207:Website
77:Parents
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714:Nature
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306:Career
165:(2008)
163:
154:Thesis
121:Fields
100:Awards
48:, U.S.
789:S2CID
746:S2CID
694:S2CID
216:.ucla
214:.chem
212:doyle
781:PMID
738:PMID
686:PMID
637:PMID
619:ISSN
553:PMID
535:ISSN
496:PMID
488:ISSN
449:PMID
441:ISSN
245:and
218:.edu
29:Born
773:doi
730:doi
718:590
676:doi
664:360
627:PMC
611:doi
599:345
543:PMC
527:doi
523:130
480:doi
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429:127
70:PhD
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