148:: The gametocytes, flagellated microgametocytes (males) and the unflagellated megagametocytes (females) are ingested during bloodmeal by mosquitoes, which then enter into the cyst phase, sporozoites, and undergo a series of asexual reproduction. After a span of 10-18 days, the sporozoite moves to the mosquito's salivary gland. In a subsequent blood meal on another human, anticoagulant saliva is injected along with the sporozoites, which then migrate to the liver, initiating a new cycle.
898:
103:
841:
69:
95:. Malaria is recorded as the most common disease in Sub-Saharan Africa, and some Asian countries with the highest number of deaths. Studies have shown the increased prevalence of this disease since 2015. This protozoan has several other subspecies, with some causing diseases in humans with over 91,000 death in 2021 from malaria (
55:
form. They are often different from the cyst stage, which is a protective, dormant form of the protozoa. Trophozoites are often found in the host's body fluids and tissues and in many cases, they are the form of the protozoan that causes disease in the host. In the protozoan,
291:
López-Soto F, León-Sicairos N, Reyes-López M, Serrano-Luna J, Ordaz-Pichardo C, Piña-Vázquez C, et al. (December 2009). "Use and endocytosis of iron-containing proteins by
Entamoeba histolytica trophozoites".
565:
Billker O, Lindo V, Panico M, Etienne AE, Paxton T, Dell A, et al. (March 1998). "Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito".
60:
it invades the intestinal mucosa of its host, causing dysentery, which aid in the trophozoites traveling to the liver and leading to the production of hepatic abscesses.
138:
in the early trophozoite phase, which cause the malaria symptoms in humans. These mature and go through sexual reproduction, known as gametogenesis to produce the
708:
196:
colonizes and proliferates in the small intestine. Trophozoites develop during the course of the infection into cysts which is the infectious life stage.
142:(occurring in male and female forms) in the late trophozoite phase in the bloodstream that are picked up by other mosquitoes during blood meals.d
882:
134:
which enter into the blood of the individual (Erythrocytic Cycle). The schizonts mature and divide asexually to form thousands of
939:
387:
518:"Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells"
224:
722:
Gazzinelli RT, Kalantari P, Fitzgerald KA, Golenbock DT (November 2014). "Innate sensing of malaria parasites".
126:
into the bloodstream during a bloodmeal. The sporozoites travel to the liver where they invade liver cells (
875:
932:
516:
Mitchell CM, McLemore L, Westerberg K, Astronomo R, Smythe K, Gardella C, et al. (August 2014).
405:"Are malaria elimination efforts on right track? An analysis of gains achieved and challenges ahead"
963:
665:
Rajagopalan PK (2019-04-02). "Malaria
Remains Unshaken and the Mighty Mosquito Remains Unbeaten".
481:
Kooij TW, Matuschewski K (December 2007). "Triggers and tricks of
Plasmodium sexual development".
370:"Pan American Health Organization (PAHO) Regional Office of the World Health Organization (WHO)".
335:
White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM (February 2014). "Malaria".
968:
868:
169:
925:
99:) alone, which is a 77% increase from 2020 as reported by the World Health Organization (WHO).
958:
702:
41:
574:
301:
130:) in the Exo-erythrocytic Cycle. The sporozoites in the infected liver cells ruptures into
803:
Einarsson E, Ma'ayeh S, Svärd SG (December 2016). "An up-date on
Giardia and giardiasis".
8:
578:
305:
747:
690:
647:
598:
542:
517:
431:
404:
268:
241:
173:
92:
348:
913:
856:
820:
785:
739:
694:
682:
639:
634:
617:
590:
547:
498:
436:
383:
352:
317:
273:
220:
122:: The infected female mosquito (usually Anopheles species) bites a human and injects
751:
651:
812:
777:
731:
674:
629:
602:
582:
537:
529:
490:
463:
426:
416:
375:
344:
309:
263:
253:
160:
108:
379:
313:
192:
467:
172:
the trophozoite undergoes schizogony (asexual reproduction) and develops into a
909:
852:
52:
816:
678:
494:
421:
290:
258:
214:
952:
789:
686:
165:
533:
824:
743:
643:
551:
502:
440:
356:
321:
277:
51:
group. The complementary form of the trophozoite state is the thick-walled
594:
239:
765:
242:"Entamoeba histolytica: adhesins and lectins in the trophozoite surface"
102:
781:
177:
139:
127:
123:
31:, animal) is the activated, feeding stage in the life cycle of certain
897:
721:
240:
Aguirre García M, Gutiérrez-Kobeh L, López
Vancell R (February 2015).
848:
135:
735:
68:
905:
515:
131:
32:
586:
84:
47:
36:
618:"Immunity to asexual blood stage malaria and vaccine approaches"
16:
Activated, feeding stage in the life cycle of certain protozoa
840:
334:
216:
Protozoa: Structure, Classification, Growth, and
Development
454:
Walker NF, Nadjm B, Whitty CJ (February 2014). "Malaria".
802:
564:
374:. London: Palgrave Macmillan UK. 2018. p. 584.
616:Wipasa J, Elliott S, Xu H, Good MF (October 2002).
615:
219:. University of Texas Medical Branch at Galveston.
115:The Malaria lifecycle is divided into two phases:
707:: CS1 maint: DOI inactive as of September 2024 (
480:
453:
950:
766:"Malaria: Control, Elimination, and Eradication"
933:
876:
664:
940:
926:
883:
869:
633:
541:
430:
420:
267:
257:
76:
101:
67:
951:
402:
212:
206:
892:
835:
63:
152:
13:
522:The Journal of Infectious Diseases
14:
980:
294:Infection, Genetics and Evolution
213:Yaeger RG (1996). Baron S (ed.).
896:
839:
667:Journal of Communicable Diseases
635:10.1046/j.1440-1711.2002.01107.x
91:, that is carried by the female
805:Current Opinion in Microbiology
796:
758:
715:
658:
609:
558:
483:Current Opinion in Microbiology
509:
474:
447:
409:Infectious Diseases of Poverty
396:
363:
328:
284:
233:
190:The trophozoite life stage of
1:
380:10.1007/978-1-349-94186-5_904
349:10.1016/s0140-6736(13)60024-0
199:
912:. You can help Knowledge by
855:. You can help Knowledge by
314:10.1016/j.meegid.2009.05.018
7:
622:Immunology and Cell Biology
468:10.1016/j.mpmed.2013.11.011
10:
985:
891:
834:
724:Nature Reviews. Immunology
403:Dhiman S (February 2019).
183:
164:is the causative agent of
83:The causative organism of
817:10.1016/j.mib.2016.07.019
679:10.24321/0019.5138.201906
495:10.1016/j.mib.2007.09.015
422:10.1186/s40249-019-0524-x
259:10.3390/molecules20022802
904:This article related to
770:Human Parasitic Diseases
372:The Grants Register 2018
681:(inactive 2024-09-12).
170:apicomplexan life cycle
851:-related article is a
112:
97:Plasmodium falciparium
89:Plasmodium falciparium
78:Plasmodium falciparium
73:
534:10.1093/infdis/jiu176
105:
71:
58:Entamoeba histolytica
42:Plasmodium falciparum
579:1998Natur.392..289B
306:2009InfGE...9.1038L
782:10.4137/hpd.s16590
113:
93:Anopheles mosquito
74:
921:
920:
864:
863:
573:(6673): 289–292.
389:978-1-137-59209-5
343:(9918): 723–735.
72:Malaria Lifecycle
64:Life cycle stages
45:and those of the
976:
942:
935:
928:
900:
893:
885:
878:
871:
843:
836:
829:
828:
800:
794:
793:
762:
756:
755:
719:
713:
712:
706:
698:
662:
656:
655:
637:
613:
607:
606:
562:
556:
555:
545:
513:
507:
506:
478:
472:
471:
451:
445:
444:
434:
424:
400:
394:
393:
367:
361:
360:
332:
326:
325:
300:(6): 1038–1050.
288:
282:
281:
271:
261:
252:(2): 2802–2815.
237:
231:
230:
210:
161:Balantidium coli
154:Balantidium coli
109:Balantidium coli
87:is a protozoan,
27:, nourishment +
984:
983:
979:
978:
977:
975:
974:
973:
964:Eukaryote stubs
949:
948:
947:
946:
890:
889:
833:
832:
801:
797:
776:: 11–15. 2016.
764:
763:
759:
736:10.1038/nri3742
730:(11): 744–757.
720:
716:
700:
699:
663:
659:
614:
610:
563:
559:
514:
510:
479:
475:
452:
448:
401:
397:
390:
369:
368:
364:
333:
329:
289:
285:
238:
234:
227:
211:
207:
202:
188:
176:which contains
157:
81:
66:
17:
12:
11:
5:
982:
972:
971:
969:Parasite stubs
966:
961:
945:
944:
937:
930:
922:
919:
918:
901:
888:
887:
880:
873:
865:
862:
861:
844:
831:
830:
795:
757:
714:
657:
628:(5): 401–414.
608:
557:
528:(4): 651–655.
508:
489:(6): 547–553.
473:
462:(2): 100–106.
446:
395:
388:
362:
327:
283:
232:
225:
204:
203:
201:
198:
187:
182:
156:
151:
150:
149:
143:
106:Life cycle of
80:
75:
65:
62:
15:
9:
6:
4:
3:
2:
981:
970:
967:
965:
962:
960:
957:
956:
954:
943:
938:
936:
931:
929:
924:
923:
917:
915:
911:
907:
902:
899:
895:
894:
886:
881:
879:
874:
872:
867:
866:
860:
858:
854:
850:
845:
842:
838:
837:
826:
822:
818:
814:
810:
806:
799:
791:
787:
783:
779:
775:
771:
767:
761:
753:
749:
745:
741:
737:
733:
729:
725:
718:
710:
704:
696:
692:
688:
684:
680:
676:
672:
668:
661:
653:
649:
645:
641:
636:
631:
627:
623:
619:
612:
604:
600:
596:
592:
588:
587:10.1038/32667
584:
580:
576:
572:
568:
561:
553:
549:
544:
539:
535:
531:
527:
523:
519:
512:
504:
500:
496:
492:
488:
484:
477:
469:
465:
461:
457:
450:
442:
438:
433:
428:
423:
418:
414:
410:
406:
399:
391:
385:
381:
377:
373:
366:
358:
354:
350:
346:
342:
338:
331:
323:
319:
315:
311:
307:
303:
299:
295:
287:
279:
275:
270:
265:
260:
255:
251:
247:
243:
236:
228:
226:9780963117212
222:
218:
217:
209:
205:
197:
195:
194:
186:
181:
179:
175:
171:
167:
166:balantidiasis
163:
162:
155:
147:
144:
141:
137:
133:
129:
125:
121:
118:
117:
116:
111:
110:
104:
100:
98:
94:
90:
86:
79:
70:
61:
59:
54:
50:
49:
44:
43:
38:
34:
30:
26:
22:
959:Parasitology
914:expanding it
903:
857:expanding it
846:
808:
804:
798:
773:
769:
760:
727:
723:
717:
703:cite journal
673:(1): 43–49.
670:
666:
660:
625:
621:
611:
570:
566:
560:
525:
521:
511:
486:
482:
476:
459:
455:
449:
412:
408:
398:
371:
365:
340:
336:
330:
297:
293:
286:
249:
245:
235:
215:
208:
191:
189:
184:
159:
158:
153:
145:
119:
114:
107:
96:
88:
82:
77:
57:
46:
40:
28:
24:
20:
18:
140:gametocytes
128:hepatocytes
124:sporozoites
21:trophozoite
953:Categories
200:References
178:merozoites
136:merozoites
906:parasites
849:eukaryote
811:: 47–52.
790:1179-5700
695:134359453
687:0019-5138
415:(1): 14.
246:Molecules
168:. In the
132:schizonts
39:-causing
825:27501461
752:23050925
744:25324127
652:24675596
644:12225376
552:24652495
503:18006365
456:Medicine
441:30760324
357:23953767
322:19539057
278:25671365
174:schizont
146:Mosquito
35:such as
33:protozoa
603:2584314
595:9521324
575:Bibcode
543:4172039
432:6375178
302:Bibcode
269:6272351
193:Giardia
185:Giardia
85:malaria
48:Giardia
37:malaria
823:
788:
750:
742:
693:
685:
650:
642:
601:
593:
567:Nature
550:
540:
501:
439:
429:
386:
355:
337:Lancet
320:
276:
266:
223:
908:is a
847:This
748:S2CID
691:S2CID
648:S2CID
599:S2CID
120:Human
25:trope
910:stub
853:stub
821:PMID
786:ISSN
740:PMID
709:link
683:ISSN
640:PMID
591:PMID
548:PMID
499:PMID
437:PMID
384:ISBN
353:PMID
318:PMID
274:PMID
221:ISBN
53:cyst
29:zoon
23:(G.
813:doi
778:doi
732:doi
675:doi
630:doi
583:doi
571:392
538:PMC
530:doi
526:210
491:doi
464:doi
427:PMC
417:doi
376:doi
345:doi
341:383
310:doi
264:PMC
254:doi
955::
819:.
809:34
807:.
784:.
772:.
768:.
746:.
738:.
728:14
726:.
705:}}
701:{{
689:.
671:51
669:.
646:.
638:.
626:80
624:.
620:.
597:.
589:.
581:.
569:.
546:.
536:.
524:.
520:.
497:.
487:10
485:.
460:42
458:.
435:.
425:.
411:.
407:.
382:.
351:.
339:.
316:.
308:.
296:.
272:.
262:.
250:20
248:.
244:.
180:.
19:A
941:e
934:t
927:v
916:.
884:e
877:t
870:v
859:.
827:.
815::
792:.
780::
774:8
754:.
734::
711:)
697:.
677::
654:.
632::
605:.
585::
577::
554:.
532::
505:.
493::
470:.
466::
443:.
419::
413:8
392:.
378::
359:.
347::
324:.
312::
304::
298:9
280:.
256::
229:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.