40:
510:
487:
31:
2274:
2262:
740:
of women with high-grade and low-grade precancerous conditions. After three months of treatment, 82.6% of the women who had high-grade disease had normal cervical conditions, confirmed by smears and biopsies. Lopinavir has been shown to impair protein synthesis via AMP-activated protein kinase
621:
InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
579:
796:
717:(CSF). Anecdotal reports state that lopinavir cannot be detected in the CSF; however, a study of paired CSF-plasma samples from 26 patients receiving lopinavir/ritonavir found lopinavir CSF levels above the
1659:
1633:
1551:
1653:
682:, especially among children living with HIV. Lopinavir and ritonavir can be taken as a tablet or an oral solution, a preferred option in children. In the early stages of
1843:
1848:
1075:"Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture"
1794:
1266:
2233:
153:
1430:
1800:
111:
1858:
1778:
1863:
1811:
1212:
776:
60:
1833:
1817:
678:
It was patented in 1995 and approved for medical use in 2000. Considered now as second-line therapy in the West, it is still prescribed in
593:
2186:
2181:
1828:
1838:
2105:
1749:
664:
2204:
2095:
1853:
1190:
846:"Systems and Clinical Pharmacology of COVID-19 Therapeutic Candidates: A Clinical and Translational Medicine Perspective"
2314:
1868:
1073:
de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van
Nieuwkoop S, Bestebroer TM, et al. (August 2014).
1424:
1205:
828:
656:
638:
613:
128:
2304:
2221:
1878:
1762:
1888:
1873:
1536:
1524:
296:
187:
92:
893:
Kaletra (lopinavir/ritonavir) capsules; (lopinavir/ritonavir) oral solution. Prescribing information. April 2009
39:
1768:
1198:
742:
505:
406:
2299:
1973:
967:"Protein phosphatase 1 regulates Human Cytomegalovirus protein translation by restraining AMPK signaling"
466:
2294:
2252:
455:
106:
779:
injectable formulation of lopinavir is under clinical trial aiming at monthly dosing (NCT05850728).
2045:
1955:
1936:
1823:
1784:
698:
Side effects, interactions, and contraindications have only been evaluated in the drug combination
482:
965:
Stecher C, Marinkov S, Mayr-Harting L, Katic A, Kastner MT, Rieder-Rommer FJ, et al. (2021).
904:
Capparelli EV, Holland D, Okamoto C, Gragg B, Durelle J, Marquie-Beck J, et al. (June 2005).
2209:
1805:
906:"Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV"
772:. In this trial the medication was started typically around 13 days after the start of symptoms.
139:
2309:
1883:
1024:
Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, et al. (November 2014).
243:
1991:
1026:"1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription"
818:
2080:
1893:
1773:
1643:
1242:
952:
750:
733:
330:
2319:
1963:
1789:
1638:
1396:
415:
395:
265:
1220:
8:
1898:
1757:
1629:
1547:
1346:
1225:
1179:
765:
714:
699:
672:
321:
171:
146:
922:
905:
736:(HPV). The study used the equivalent of one tablet twice a day applied topically to the
509:
486:
1152:
1125:
1101:
1074:
1050:
1025:
1001:
966:
935:
870:
845:
2040:
1703:
1157:
1106:
1055:
1006:
988:
927:
875:
824:
215:
202:
84:
70:
2065:
1147:
1137:
1096:
1086:
1045:
1037:
996:
978:
939:
917:
865:
857:
522:
225:
166:
2239:
355:
312:--4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
2266:
2141:
2100:
1260:
253:
233:
2324:
2278:
2215:
1221:
892:
861:
844:
Perazzolo, Simone; Zhu; Lin, Weixian; Nguyen, Alexander; Ho, Rodney JY (2021).
983:
2288:
1981:
1731:
1566:
1452:
992:
660:
498:
1126:"A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19"
2035:
2025:
1606:
1596:
1414:
1371:
1366:
1361:
1323:
1303:
1233:
1161:
1110:
1059:
1010:
931:
879:
761:
161:
1142:
22:
2161:
2136:
2075:
2060:
2055:
1719:
1686:
1601:
1581:
1376:
1356:
1335:
1282:
1250:
1091:
78:
1072:
375:
2166:
2146:
2131:
2126:
2090:
2085:
1999:
1944:
1914:
1726:
1714:
1709:
1681:
1621:
1611:
1586:
1571:
1561:
1510:
1505:
1493:
1477:
1467:
1447:
1409:
1319:
1307:
1299:
687:
652:
601:
O=C(N(Cc1ccccc1)(O)C(NC(=O)(N2C(=O)NCCC2)C(C)C)Cc3ccccc3)COc4c(cccc4C)C
555:
386:
1041:
30:
2176:
2156:
2151:
2121:
2050:
2030:
1919:
1676:
1591:
1576:
1499:
1472:
1457:
1404:
1381:
1294:
953:
HIV drug used to reverse effects of virus that causes cervical cancer
749:) activation, a mechanism that is similar to the antiviral effect of
668:
341:
278:
64:
1124:
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. (May 2020).
2171:
1556:
769:
757:
713:
Reports are contradictory regarding lopinavir penetration into the
683:
435:
366:
123:
578:
2070:
1616:
1386:
964:
2020:
2015:
737:
732:
A 2014 study indicates that lopinavir is effective against the
446:
110:
1330:
903:
746:
569:
258:
2273:
471:
1844:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
1289:
1277:
718:
679:
426:
1849:
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
1023:
1314:
1229:
1795:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide
710:
Lopinavir is highly bound to plasma proteins (98–99%).
690:
virus in the hope of disturbing its protease activity.
2250:
843:
702:. They include nausea, vomiting, and stomach aches.
2286:
1801:Dolutegravir/emtricitabine/tenofovir alafenamide
686:pandemics, lopinavir was repurposed against the
354:
1859:Emtricitabine/rilpivirine/tenofovir alafenamide
1779:Bictegravir/emtricitabine/tenofovir alafenamide
816:
329:
1864:Emtricitabine/rilpivirine/tenofovir disoproxil
1350:(Integrase strand transfer inhibitors (INSTI))
1812:Dolutegravir/lamivudine/tenofovir alafenamide
1206:
1123:
1834:Efavirenz/emtricitabine/tenofovir disoproxil
1818:Dolutegravir/lamivudine/tenofovir disoproxil
127:
955:University of Manchester, 17 February 2014.
760:replication in the low-micromolar range in
1829:Doravirine/lamivudine/tenofovir disoproxil
1213:
1199:
508:
485:
394:
38:
29:
1839:Efavirenz/lamivudine/tenofovir disoproxil
1151:
1141:
1100:
1090:
1049:
1000:
982:
921:
869:
414:
2106:Zinc finger protein transcription factor
481:
374:
83:
2287:
823:. John Wiley & Sons. p. 510.
810:
499:
196:
101:
1194:
1079:Antimicrobial Agents and Chemotherapy
797:"FDA Approved Drug Products: Kaletra"
454:
209:
118:
69:
1186:. U.S. National Library of Medicine.
886:
165:
1854:Emtricitabine/tenofovir alafenamide
1130:The New England Journal of Medicine
923:10.1097/01.aids.0000171409.38490.48
434:
345:
13:
1869:Emtricitabine/tenofovir disoproxil
14:
2336:
1172:
667:with another protease inhibitor,
2272:
2260:
2242:. Formerly or rarely used agent.
1879:Lamivudine/nevirapine/zidovudine
1763:Abacavir/dolutegravir/lamivudine
768:was found not to work in severe
539:
533:
2046:Epigallocatechin gallate (EGCG)
1889:Lamivudine/tenofovir disoproxil
1874:Lamivudine/nevirapine/stavudine
1117:
1030:British Journal of Pharmacology
817:Fischer J, Ganellin CR (2006).
756:Lopinavir was found to inhibit
705:
693:
626:Key:KJHKTHWMRKYKJE-SUGCFTRWSA-N
1769:Abacavir/lamivudine/zidovudine
1066:
1017:
958:
946:
897:
837:
789:
545:
527:
1:
820:Analogue-based Drug Discovery
782:
7:
1644:Tenofovir alafenamide (TAF)
727:
10:
2341:
1639:Tenofovir disoproxil (TDF)
862:10.1016/j.xphs.2020.11.019
659:class. It is used against
517:Chemical and physical data
2315:Drugs developed by AbbVie
2199:
2114:
2008:
1990:
1972:
1954:
1935:
1928:
1907:
1748:
1695:
1669:
1660:Discovery and development
1652:
1535:
1523:
1486:
1440:
1431:Discovery and development
1423:
1395:
1345:
1267:Discovery and development
1259:
1241:
984:10.3389/fmicb.2021.698603
971:Frontiers in Microbiology
634:
609:
589:
567:
554:
521:
516:
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465:
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365:
340:
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292:
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264:
252:
242:
232:
224:
186:
181:
152:
138:
91:
77:
59:
51:
46:
37:
28:
1956:Transcription inhibitors
1908:Pharmacokinetic boosters
1824:Dolutegravir/rilpivirine
1785:Cabotegravir/rilpivirine
1425:Protease Inhibitors (PI)
71:International Drug Names
2305:HIV protease inhibitors
2240:initial regimen options
1806:Dolutegravir/lamivudine
1283:Enfuvirtide (ENF, T-20)
1261:Entry/fusion inhibitors
1184:Drug Information Portal
2081:Portmanteau inhibitors
1974:Translation inhibitors
1884:Lamivudine/raltegravir
1654:Non-nucleoside (NNRTI)
1612:Islatravir (EFdA, ISL)
665:fixed-dose combination
2096:Synergistic enhancers
1894:Lamivudine/zidovudine
1774:Atazanavir/cobicistat
1750:Combined formulations
1587:Zidovudine (AZT, ZDV)
1525:Reverse-transcriptase
1397:Maturation inhibitors
1143:10.1056/NEJMoa2001282
751:protein phosphatase 1
734:human papilloma virus
1937:Uncoating inhibitors
1790:Darunavir/cobicistat
1630:Nucleotide analogues
1548:Nucleoside analogues
1347:Integrase inhibitors
1226:antiretroviral drugs
1092:10.1128/AAC.03011-14
1929:Experimental agents
1899:Lopinavir/ritonavir
1758:Abacavir/lamivudine
1732:Elsulfavirine (ESV)
1567:Emtricitabine (FTC)
1453:Fosamprenavir (FPV)
766:lopinavir/ritonavir
745:) and eEF2 kinase (
724:in 77% of samples.
715:cerebrospinal fluid
700:lopinavir/ritonavir
673:lopinavir/ritonavir
205:(Prescription only)
25:
2300:Secondary alcohols
2226:Never to phase III
1372:Elvitegravir (EVG)
1367:Dolutegravir (DTG)
1362:Cabotegravir (CAB)
657:protease inhibitor
21:
2295:CYP3A4 inhibitors
2248:
2247:
2195:
2194:
2041:Diarylpyrimidines
1744:
1743:
1740:
1739:
1720:Rilpivirine (RPV)
1704:diarylpyrimidines
1687:Delavirdine (DLV)
1582:Zalcitabine (ddC)
1539:nucleotide (NRTI)
1519:
1518:
1377:Raltegravir (RAL)
1357:Bictegravir (BIC)
1336:Fostemsavir (FTR)
1251:Lenacapavir (LEN)
1243:Capsid inhibitors
1136:(19): 1787–1799.
1042:10.1111/bph.12863
646:
645:
580:Interactive image
467:CompTox Dashboard
213:
200:
121:
104:
16:Chemical compound
2332:
2277:
2276:
2265:
2264:
2263:
2256:
2066:Hydroxycarbamide
1933:
1932:
1727:Doravirine (DOR)
1715:Etravirine (ETR)
1710:Dapivirine (DPV)
1682:Nevirapine (NVP)
1667:
1666:
1572:Lamivudine (3TC)
1562:Didanosine (ddI)
1533:
1532:
1506:Tipranavir (TPV)
1494:Atazanavir (ATV)
1478:Saquinavir (SQV)
1468:Nelfinavir (NFV)
1448:Amprenavir (APV)
1438:
1437:
1320:Ibalizumab (IBA)
1215:
1208:
1201:
1192:
1191:
1187:
1166:
1165:
1155:
1145:
1121:
1115:
1114:
1104:
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1070:
1064:
1063:
1053:
1021:
1015:
1014:
1004:
986:
962:
956:
950:
944:
943:
925:
901:
895:
890:
884:
883:
873:
856:(3): 1002–1017.
841:
835:
834:
814:
808:
807:
805:
803:
793:
642:
641:
582:
562:
547:
541:
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42:
33:
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20:
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2329:
2285:
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2271:
2261:
2259:
2251:
2249:
2244:
2243:
2231:
2216:Clinical trials
2191:
2142:Dexelvucitabine
2110:
2101:Tre recombinase
2004:
1986:
1968:
1964:Tat antagonists
1950:
1924:
1903:
1736:
1691:
1677:Efavirenz (EFV)
1656:
1648:
1577:Stavudine (d4T)
1538:
1526:
1515:
1500:Darunavir (DRV)
1482:
1473:Ritonavir (RTV)
1463:Lopinavir (LPV)
1458:Indinavir (IDV)
1427:
1419:
1391:
1349:
1341:
1295:Maraviroc (MVC)
1263:
1255:
1237:
1222:Antiviral drugs
1219:
1178:
1175:
1170:
1169:
1122:
1118:
1071:
1067:
1036:(22): 5059–75.
1022:
1018:
963:
959:
951:
947:
902:
898:
891:
887:
842:
838:
831:
815:
811:
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469:
461:
441:
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401:
381:
361:
344:
336:
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300:
299:
267:
244:Protein binding
234:Bioavailability
226:Pharmacokinetic
220:
177:
141:
134:
17:
12:
11:
5:
2338:
2328:
2327:
2322:
2317:
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2307:
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2297:
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2174:
2169:
2164:
2159:
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2144:
2139:
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2129:
2124:
2118:
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2112:
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2109:
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2103:
2098:
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2083:
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2068:
2063:
2058:
2053:
2048:
2043:
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2028:
2023:
2018:
2012:
2010:
2006:
2005:
2003:
2002:
1996:
1994:
1988:
1987:
1985:
1984:
1978:
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1970:
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1967:
1966:
1960:
1958:
1952:
1951:
1949:
1948:
1941:
1939:
1930:
1926:
1925:
1923:
1922:
1917:
1915:Cobicistat (c)
1911:
1909:
1905:
1904:
1902:
1901:
1896:
1891:
1886:
1881:
1876:
1871:
1866:
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1604:
1599:
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1589:
1584:
1579:
1574:
1569:
1564:
1559:
1557:Abacavir (ABC)
1543:
1541:
1537:Nucleoside and
1530:
1521:
1520:
1517:
1516:
1514:
1513:
1508:
1503:
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1195:
1189:
1188:
1174:
1173:External links
1171:
1168:
1167:
1116:
1085:(8): 4875–84.
1065:
1016:
957:
945:
896:
885:
836:
829:
809:
787:
786:
784:
781:
729:
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695:
692:
661:HIV infections
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179:
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175:
172:with ritonavir
158:
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150:
149:
144:
142:administration
136:
135:
133:
132:
115:
97:
95:
89:
88:
81:
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2310:Phenol ethers
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2115:Failed agents
2113:
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1982:Trichosanthin
1980:
1979:
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1975:
1971:
1965:
1962:
1961:
1959:
1957:
1953:
1946:
1943:
1942:
1940:
1938:
1934:
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1920:Ritonavir (r)
1918:
1916:
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1900:
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500:ECHA InfoCard
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47:Clinical data
45:
41:
36:
32:
27:
19:
2236:
2036:Cyanovirin-N
2026:Calanolide A
1702:
1696:2 generation
1670:1 generation
1657:
1628:
1607:Elvucitabine
1597:Apricitabine
1546:
1487:2 generation
1462:
1441:1 generation
1428:
1415:Fipravirimat
1329:
1324:Semzuvolimab
1313:
1304:Cenicriviroc
1288:
1276:
1264:
1183:
1133:
1129:
1119:
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1078:
1068:
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812:
800:. Retrieved
791:
774:
755:
753:inhibitors.
731:
712:
709:
706:Pharmacology
697:
694:Side effects
677:
648:
647:
636:
309:
305:
283:Mostly fecal
273:5 to 6 hours
266:Elimination
188:Legal status
182:Legal status
93:License data
18:
2320:Pyrimidones
2237:recommended
2212:from market
2162:Lersivirine
2137:Capravirine
2076:Miltefosine
2061:Griffithsin
2056:Fosdevirine
1602:Censavudine
1232:(primarily
1180:"Lopinavir"
850:J Pharm Sci
777:long-acting
764:. In 2020,
563: g·mol
506:100.281.362
331:192725-17-0
288:Identifiers
79:MedlinePlus
52:Other names
2289:Categories
2167:Lodenosine
2147:Droxinavir
2132:Brecanavir
2127:Atevirdine
2091:Seliciclib
2086:Scytovirin
2000:Elipovimab
1945:TRIM5alpha
1622:Stampidine
1527:inhibitors
1511:TMC-310911
1410:BMS-955176
1308:Leronlimab
1300:Vicriviroc
977:: 698603.
783:References
688:SARS-CoV-2
653:retroviral
651:is an anti
568:3D model (
556:Molar mass
416:2494G1JF75
387:ChemSpider
322:CAS Number
297:IUPAC name
254:Metabolism
2222:Phase III
2210:Withdrawn
2187:Telinavir
2182:Palinavir
2177:Mozenavir
2157:Emivirine
2152:Lasinavir
2122:Aplaviroc
2051:Foscarnet
2031:Ceragenin
1592:Amdoxovir
1405:Bevirimat
1382:BI 224436
993:1664-302X
669:ritonavir
649:Lopinavir
456:ChEMBL729
279:Excretion
268:half-life
140:Routes of
129:Lopinavir
65:Drugs.com
23:Lopinavir
2267:Medicine
2172:Loviride
1162:32187464
1111:24841269
1060:25073485
1011:34335531
932:15905676
880:33248057
802:30 April
770:COVID-19
758:MERS-CoV
738:cervices
728:Research
684:COVID-19
639:(verify)
367:DrugBank
170:) (
154:ATC code
147:By mouth
124:DailyMed
2279:Viruses
2253:Portals
2071:KP-1461
1617:Racivir
1387:MK-2048
1153:7121492
1102:4136071
1051:4253456
1002:8320725
940:3162858
871:7689305
655:of the
561:628.814
523:Formula
376:DB01601
342:PubChem
238:Unknown
164: (
162:J05AR10
126::
109::
85:a602015
55:ABT-378
2205:WHO-EM
2021:BIT225
2016:Abzyme
1947:(gene)
1634:NtRTIs
1529:(RTIs)
1160:
1150:
1109:
1099:
1058:
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1009:
999:
991:
938:
930:
878:
868:
827:
594:SMILES
447:ChEMBL
436:D01425
248:98-99%
216:℞-only
214:
201:
122:
112:by INN
105:
2325:Ureas
2009:Other
1992:BNAbs
1552:NRTIs
1331:gp120
936:S2CID
747:eEF2K
663:as a
614:InChI
570:JSmol
396:83706
356:92727
259:Liver
2234:DHHS
1290:CCR5
1278:gp41
1158:PMID
1107:PMID
1056:PMID
1007:PMID
989:ISSN
928:PMID
910:AIDS
876:PMID
825:ISBN
804:2004
743:AMPK
680:LMIC
427:KEGG
407:UNII
228:data
61:AHFS
1315:CD4
1234:J05
1230:HIV
1148:PMC
1138:doi
1134:382
1097:PMC
1087:doi
1046:PMC
1038:doi
1034:171
997:PMC
979:doi
918:doi
866:PMC
858:doi
854:110
675:).
472:EPA
346:CID
203:POM
167:WHO
107:EMA
2291::
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210:US
197:UK
119:US
102:EU
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