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From 1896 until 1902, Maximow authored numerous papers, concerning a variety of histologic problems, which established the background for his future work. In the later stages of his career, Maximow was primarily interested in the blood and the connective tissues. After demonstrating that all blood
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22 January] 1874 – December 4, 1928) was a
Russian-American scientist in the fields of Histology and Embryology whose team developed the hypothesis about the existence of "polyblasts". Maximow is renowned for his experimental work on the unitarian theory of
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in Saint
Petersburg, aged 17. During this time he completed his first scientific works, and he was awarded the gold medal for research on the "Histogenesis of experimentally induced amyloid degeneration of the liver in animals" published in the journal
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Maximow, Alexander A. (1909). "Untersuchungen über Blut und
Bindegewebe I. Die frühesten Entwicklungsstadien der Blut- und Bindegewebszellen beim Säugetierembryo, bis zum Anfang der Blutbilding in der Leber." Arch. Mikroskop. Anat. 73,
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cells develop from a common precursor cell, Maximow confirmed the unitarian theory of hematopoiesis. His other experimental work provided evidence confirming that lymphocytes of the blood and lymph nodes are undifferentiated cells.
580:
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and conducted his research with his sister
Claudia as congenial lab technician and co-worker at his side ("...(stand) ihm seine Schwester Claudia als kongeniale Laborantin und Mitarbeiterin zur Seite...")
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he could not arrange himself with living in communist Russia. He fled 1922 with his sister, his wife and his adopted son to the USA. From 1922 until his death in 1928, he served as a professor of
520:. Republished from Modern Trends in Human Leukemia VIII (1989), Ed. R. Neth, with kind permission by Springer Science and Business Media. Cell Ther Transplant. 2009;1:e.000033.01.
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Maximow, Alexander A. (1927). "Development of non-granular leucocytes (lymphocytes and monocytes) into polyblasts (macrophages) and fibroblasts in vitro".
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305:"Der Lymphozyt als gemeinsame Stammzelle der verschiedenen Blutelemente in der embryonalen Entwicklung und im postfetalen Leben der Säugetiere"
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Maximow, Alexander A. (1910). "Untersuchungen über Blut und
Bindegewebe. III. Die embryonale Histogenese des Knochenmarks der Säugetiere".
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248:," a book that became a standard text for medical students and ran to 12 editions. He also developed and introduced a unitarian theory of
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The
Lymphocyte as a stem cell common to different blood elements in embryonic development and during the post-fetal life of mammals
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He died on
December 4, 1928, in his sleep in Chicago after of a long-standing history of severe coronary arteriosclerosis.
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Konstantinov, Igor E. (2000). "In search of
Alexander A. Maximow: the man behind the Unitarian Theory of Hematopoiesis".
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Maximow, Alexander A. (1926). "Über undifferenzierte
Blutzellen und mesenchymale Keimlager im erwachsenen Organismus".
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Maximow, Alexander A. (1928). "Cultures of blood leucocytes. From lymphocyte and monocyte to connective tissue".
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175:: all blood cells develop from a common precursor cell. Maximow served as a Corresponding Member of the
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Maximow, Alexander A. (1924). "Relation of blood cells to connective tissues and endothelium."
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Friedenstein A. On stromal-hematopoietic interrelationships: Maximov's ideas and modern models
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Maximow, Alexander A. (1906). 'Über experimentelle
Erzeugung von Knochenmarkgewebe".
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Unitary theory of stem cells in adult organisms, in particular of the blood stem cell
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Military Academy of the General Staff of the Armed Forces of the Soviet Union alumni
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Cellular Therapy and Transplantation, Volume 1, Number 3, December 2009 - Focus:
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from 1903 until 1922. While he could teach and pursue his research after the
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Maximow, Alexander A. (1905). "Über Zellformen des lockeren Bindegewebes".
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267:. Bloom ultimately completed the work, which was first published in 1930.
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Maximow, Alexander A. (1927). "Morphology of the mesenchymal reactions".
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Alexander A. Maximow was born into an old and wealthy merchant family in
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Novik A.A., Ionova T.I., Gorodokin G., Smolyaninov A., Afanasyev B.V.
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Corresponding Members of the Russian Academy of Sciences (1917–1925)
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Russian Archives of pathology, clinical medicine and bacteriology
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Friedenstein A. Stromal-hematopoietic interrelationships:
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For four years before Maximow's death, fellow histologist
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University of Chicago Special Collections Research Center
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Maximow wrote "the world's most respected textbook in
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Corresponding Members of the USSR Academy of Sciences
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Weidenreich, Franz (1929). "Alexander A. Maximow †".
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378:Maximow, Alexander A. and William Bloom (1930).
537:Guide to the Alexander Maximow Papers 1902-1936
191:in Russia. From 1882 onwards he was a pupil of
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510:The Maximow 1909 centenary: A reappraisal
256:' origin and differentiation is based.
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16:Russian-American scientist (1874–1928)
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443:Perspectives in Biology and Medicine
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576:Academics from the Russian Empire
518:Maximov's ideas and modern models
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402:The University of Chicago Library
400:Biography of Alexander A. Maximow
201:Imperial Military Medical Academy
156:Alexander Alexandrowitsch Maximow
134:Imperial Military Medical Academy
83:Imperial Military Medical Academy
164:Александр Александрович Максимов
382:. Philadelphia: W. B. Saunders.
263:worked closely with him on the
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303:Maximow, Alexander A. (1909).
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596:University of Chicago faculty
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199:and in 1891 he entered the
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380:A textbook of histology
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360:Proc Soc Exp Biol Med
265:Textbook of Histology
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23:Alexander A. Maximow
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254:blood cells
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387:References
375:: 169–268.
365:: 570–572.
355:: 557–606.
335:: 533–563.
296:: 608–612.
286:: 680–757.
222:embryology
121:hematology
117:embryology
44:1874-02-03
246:histology
218:histology
183:Biography
113:histology
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325:: 1–113.
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291:Anat Anz
210:Freiburg
136:, Russia
109:Medicine
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539:at the
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230:anatomy
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467:S2CID
333:4 (4)
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
