214:
191:
2228:
2243:
417:
220:
2715:
36:
1030:
including those introduced by UV irradiation. The XPA protein appears to play a key role in NER at sites of damage as a scaffold for other repair proteins in order to ensure that the damages are appropriately excised. Among the repair proteins with which XPA interacts is a protein complex (including
1816:
Farndon PA, Morris DJ, Hardy C, McConville CM, Weissenbach J, Kilpatrick MW, Reis A (Sep 1994). "Analysis of 133 meioses places the genes for nevoid basal cell carcinoma (Gorlin) syndrome and
Fanconi anemia group C in a 2.6-cM interval and contributes to the fine map of 9q22.3".
62:
1684:
Tanaka K, Miura N, Satokata I, Miyamoto I, Yoshida MC, Satoh Y, Kondo S, Yasui A, Okayama H, Okada Y (Nov 1990). "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain".
1531:
Satokata I, Tanaka K, Yuba S, Okada Y (Mar 1992). "Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum".
2227:
227:
1563:"Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair"
1494:
Satokata I, Tanaka K, Okada Y (Mar 1992). "Molecular basis of group A xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene".
1465:
Morikawa K, Shirakawa M (Aug 2000). "Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA".
2111:"Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II"
2242:
1848:"The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor"
1366:
Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000).
740:
152:
721:
2080:
Lench NJ, Telford EA, Andersen SE, Moynihan TP, Robinson PA, Markham AF (Dec 1996). "An EST and STS-based YAC contig map of human chromosome 9q22.3".
1987:
Satokata I, Iwai K, Matsuda T, Okada Y, Tanaka K (Dec 1993). "Genomic characterization of the human DNA excision repair-controlling gene XPAC".
1125:
1651:"Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene"
1107:
59:
2236:: INTERACTIONS OF HUMAN NUCLEOTIDE EXCISION REPAIR PROTEIN XPA WITH RPA70 AND DNA: CHEMICAL SHIFT MAPPING AND 15N NMR RELAXATION STUDIES
949:
1440:
1423:
2648:
1143:
2622:
2207:
1732:"An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair"
1319:"An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair"
2144:
Hayashi T, Takao M, Tanaka K, Yasui A (Jun 1998). "ERCC1 mutations in UV-sensitive
Chinese hamster ovary (CHO) cell lines".
1090:
2283:
2338:
1424:"A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy"
2591:
2522:
213:
2606:
2051:
Topping RS, Myrand SP, Williams BL, Albert JC, States JC (Dec 1995). "Characterization of the human XPA promoter".
1027:
1094:
190:
1773:
Nagai A, Saijo M, Kuraoka I, Matsuda T, Kodo N, Nakatsu Y, Mimaki T, Mino M, Biggerstaff M, Wood RD (Jun 1995).
1268:
Nagai A, Saijo M, Kuraoka I, Matsuda T, Kodo N, Nakatsu Y, Mimaki T, Mino M, Biggerstaff M, Wood RD (Jun 1995).
1368:"XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription"
785:
2018:"The Japan Society of Human Genetics Award Lecture. Molecular analysis of xeroderma pigmentosum group A gene"
766:
2581:
2488:
132:
1054:
2510:
2334:
2327:
2251:: SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
2180:
1023:
226:
2200:
123:, XP1, XPAC, xeroderma pigmentosum, complementation group A, DNA damage recognition and repair factor
119:
1775:"Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein"
1270:"Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein"
219:
2505:
2427:
2276:
906:
140:
927:
902:
876:
855:
2617:
2527:
2322:
1062:
2383:
1936:"Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins"
1045:, a condition involving extreme sensitivity to sunlight and a high incidence of skin cancer.
1042:
2300:
2739:
2308:
2193:
1947:
1894:
1694:
1609:
1222:
8:
2718:
2405:
2269:
160:
1951:
1898:
1698:
1613:
1226:
1718:
1519:
1453:
1183:
1158:
164:
2157:
1756:
1731:
1667:
1650:
1579:
1562:
1478:
1343:
1318:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
580:
575:
570:
565:
560:
555:
550:
545:
540:
524:
519:
514:
509:
504:
499:
483:
478:
473:
468:
463:
458:
2601:
2161:
2132:
2097:
2068:
2064:
2039:
2004:
2000:
1975:
1970:
1935:
1922:
1917:
1882:
1869:
1834:
1804:
1761:
1710:
1672:
1637:
1632:
1597:
1584:
1549:
1545:
1511:
1482:
1445:
1399:
1348:
1299:
1250:
1245:
1210:
1188:
112:
52:
1523:
1457:
2153:
2122:
2089:
2060:
2029:
1996:
1965:
1955:
1912:
1902:
1859:
1826:
1794:
1786:
1751:
1743:
1722:
1702:
1662:
1627:
1617:
1574:
1541:
1503:
1474:
1435:
1389:
1379:
1338:
1330:
1289:
1281:
1240:
1230:
1178:
1170:
306:
237:
181:
20:
144:
2317:
1596:
Satokata I, Tanaka K, Miura N, Miyamoto I, Satoh Y, Kondo S, Okada Y (Dec 1990).
1174:
281:
168:
1130:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1112:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1940:
Proceedings of the
National Academy of Sciences of the United States of America
1887:
Proceedings of the
National Academy of Sciences of the United States of America
1602:
Proceedings of the
National Academy of Sciences of the United States of America
1215:
Proceedings of the
National Academy of Sciences of the United States of America
339:
2110:
1847:
2733:
2629:
2450:
445:
1960:
1907:
1622:
1235:
2596:
2565:
2515:
2498:
2445:
2398:
2127:
2093:
1864:
1830:
1790:
1747:
1486:
1449:
1403:
1384:
1367:
1334:
1285:
1192:
299:
2165:
2136:
2101:
2072:
2043:
2008:
1979:
1926:
1883:"Specific association between the human DNA repair proteins XPA and ERCC1"
1873:
1838:
1808:
1765:
1714:
1676:
1649:
Miura N, Miyamoto I, Asahina H, Satokata I, Tanaka K, Okada Y (Oct 1991).
1641:
1598:"Characterization of a splicing mutation in group A xeroderma pigmentosum"
1588:
1553:
1515:
1352:
1303:
1254:
1211:"Specific association between the human DNA repair proteins XPA and ERCC1"
989:
984:
416:
830:
811:
2532:
2353:
2292:
2034:
2017:
1507:
198:
148:
35:
1799:
1294:
89:
85:
81:
1706:
1441:
10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6
1394:
685:
265:
252:
156:
606:
nucleotide-excision repair involved in interstrand cross-link repair
2613:
973:
2560:
2312:
1881:
Li L, Elledge SJ, Peterson CA, Bales ES, Legerski RJ (May 1994).
1209:
Li L, Elledge SJ, Peterson CA, Bales ES, Legerski RJ (May 1994).
1144:"Entrez Gene: XPA xeroderma pigmentosum, complementation group A"
1005:
797:
752:
670:
666:
1774:
1365:
1269:
136:
2685:
2440:
2393:
2388:
1421:
957:
707:
546:
intrinsic apoptotic signaling pathway in response to DNA damage
425:
2185:
1561:
Miyamoto I, Miura N, Niwa H, Miyazaki J, Tanaka K (Jun 1992).
1041:
mutant individuals often show the severe clinical symptoms of
2700:
2695:
2690:
2680:
2673:
2668:
2663:
2658:
2653:
2643:
2638:
2493:
2457:
2378:
2373:
2368:
2358:
2261:
1157:
Sugitani N, Sivley RM, Perry KE, Capra JA, Chazin WJ (2016).
1058:
1035:
protein) that is capable of incising DNA at sites of damage.
1032:
621:
nucleotide-excision repair, preincision complex stabilization
2079:
1815:
1648:
2586:
2542:
2537:
2472:
2467:
2462:
2435:
2415:
2410:
2363:
2050:
1683:
1595:
1066:
1012:
1422:
Cleaver JE, Thompson LH, Richardson AS, States JC (1999).
1159:"XPA: A key scaffold for human nucleotide excision repair"
1026:(NER) is a major pathway for repairing a variety of bulky
2348:
1560:
1986:
1772:
1267:
1156:
591:
nucleotide-excision repair, preincision complex assembly
289:
2143:
1530:
2181:
GeneReviews/NIH/NCBI/UW entry on
Xeroderma Pigmentosum
1880:
1208:
656:
nucleotide-excision repair, DNA incision, 3'-to lesion
601:
nucleotide-excision repair, DNA incision, 5'-to lesion
406:
1729:
1316:
1845:
1779:
1493:
1274:
Biochemical and Biophysical Research Communications
1086:
1084:
1082:
626:nucleotide-excision repair, DNA damage recognition
1730:Li L, Lu X, Peterson CA, Legerski RJ (Oct 1995).
1464:
1317:Li L, Lu X, Peterson CA, Legerski RJ (Oct 1995).
236:
2731:
1846:Park CH, Mu D, Reardon JT, Sancar A (Mar 1995).
651:nucleotide-excision repair, DNA duplex unwinding
551:transcription-coupled nucleotide-excision repair
1079:
16:Protein-coding gene in the species Homo sapiens
1091:GRCm38: Ensembl release 89: ENSMUSG00000028329
2277:
2201:
1204:
1202:
2108:
1359:
1150:
1002:DNA repair protein complementing XP-A cells
510:nucleotide-excision repair factor 1 complex
2284:
2270:
2208:
2194:
1933:
1310:
1261:
1199:
2126:
2033:
1969:
1959:
1916:
1906:
1863:
1798:
1755:
1666:
1631:
1621:
1578:
1439:
1393:
1383:
1342:
1293:
1244:
1234:
1182:
576:global genome nucleotide-excision repair
561:cellular response to DNA damage stimulus
541:nucleotide-excision repair, DNA incision
2732:
2022:The Japanese Journal of Human Genetics
2015:
2265:
2189:
1136:
241:
202:
197:
2115:The Journal of Biological Chemistry
1852:The Journal of Biological Chemistry
1655:The Journal of Biological Chemistry
1567:The Journal of Biological Chemistry
1372:The Journal of Biological Chemistry
13:
2592:Proliferating Cell Nuclear Antigen
2523:Microhomology-mediated end joining
1414:
14:
2751:
2174:
1008:that in humans is encoded by the
469:protein homodimerization activity
2714:
2713:
2607:Meiotic recombination checkpoint
2241:
2226:
505:DNA replication factor A complex
415:
225:
218:
212:
189:
34:
2215:
2109:Selby CP, Sancar A (Jan 1997).
1048:
641:protein localization to nucleus
464:protein domain specific binding
2291:
1934:Park CH, Sancar A (May 1994).
1736:Molecular and Cellular Biology
1323:Molecular and Cellular Biology
1118:
1100:
426:More reference expression data
1:
2158:10.1016/s0921-8777(98)00013-5
1668:10.1016/S0021-9258(18)55060-2
1580:10.1016/S0021-9258(19)49821-9
1479:10.1016/s0921-8777(00)00031-8
1072:
571:multicellular organism growth
566:response to auditory stimulus
210:
2489:Transcription-coupled repair
2065:10.1016/0378-1119(95)00649-4
2001:10.1016/0378-1119(93)90493-M
1546:10.1016/0921-8777(92)90081-d
1175:10.1016/j.dnarep.2016.05.018
556:response to oxidative stress
19:For the ISO 639-3 code, see
7:
1018:
581:response to toxic substance
10:
2756:
2511:Non-homologous end joining
2335:Nucleotide excision repair
2328:Poly ADP ribose polymerase
1024:Nucleotide excision repair
596:nucleotide-excision repair
18:
2709:
2574:
2553:
2481:
2426:
2299:
2221:
1126:"Mouse PubMed Reference:"
1108:"Human PubMed Reference:"
988:
983:
979:
972:
956:
939:
924:
920:
899:
895:
888:
873:
869:
852:
848:
841:
828:
824:
809:
805:
796:
783:
779:
764:
760:
751:
738:
734:
719:
715:
706:
691:
684:
680:
664:
611:UV-damage excision repair
444:
440:
423:
414:
405:
397:
346:
337:
322:
318:
288:
280:
276:
259:
246:
209:
188:
179:
175:
130:
127:
117:
110:
105:
78:
73:
56:
51:
46:
42:
33:
28:
2506:Homology directed repair
2428:Homologous recombination
1961:10.1073/pnas.91.11.5017
1908:10.1073/pnas.91.11.5012
1623:10.1073/pnas.87.24.9908
1236:10.1073/pnas.91.11.5012
646:regulation of autophagy
2528:Postreplication repair
2323:Uracil-DNA glycosylase
2128:10.1074/jbc.272.3.1885
2094:10.1006/geno.1996.0616
1865:10.1074/jbc.270.9.4896
1831:10.1006/geno.1994.1528
1791:10.1006/bbrc.1995.1905
1748:10.1128/mcb.15.10.5396
1385:10.1074/jbc.M004936200
1335:10.1128/mcb.15.10.5396
1286:10.1006/bbrc.1995.1905
1063:Replication protein A1
1053:XPA has been shown to
950:Chr 4: 46.16 – 46.2 Mb
358:neural layer of retina
2016:Tanaka K (Mar 1993).
1043:xeroderma pigmentosum
2634:core protein complex
2309:Base excision repair
616:base-excision repair
500:intercellular bridge
243:4 B1|4 24.49 cM
204:Chromosome 4 (mouse)
74:List of PDB id codes
47:Available structures
2406:DNA mismatch repair
1952:1994PNAS...91.5017P
1899:1994PNAS...91.5012L
1699:1990Natur.348...73T
1614:1990PNAS...87.9908S
1227:1994PNAS...91.5012L
484:damaged DNA binding
370:ganglionic eminence
2035:10.1007/BF01891230
1508:10.1007/BF02265282
1163:DNA Repair (Amst.)
786:ENSMUSG00000028329
534:Biological process
493:Cellular component
452:Molecular function
2727:
2726:
2602:Adaptive response
2259:
2258:
2146:Mutation Research
1534:Mutation Research
1467:Mutation Research
999:
998:
995:
994:
968:
967:
935:
934:
914:
913:
884:
883:
863:
862:
837:
836:
818:
817:
792:
791:
773:
772:
747:
746:
728:
727:
676:
675:
459:metal ion binding
436:
435:
432:
431:
401:
400:
393:
392:
331:
330:
272:
271:
101:
100:
97:
96:
57:Ortholog search:
2747:
2717:
2716:
2286:
2279:
2272:
2263:
2262:
2245:
2230:
2210:
2203:
2196:
2187:
2186:
2169:
2140:
2130:
2105:
2076:
2047:
2037:
2012:
1983:
1973:
1963:
1930:
1920:
1910:
1877:
1867:
1842:
1812:
1802:
1769:
1759:
1742:(10): 5396–402.
1726:
1707:10.1038/348073a0
1680:
1670:
1645:
1635:
1625:
1592:
1582:
1557:
1527:
1490:
1461:
1443:
1408:
1407:
1397:
1387:
1363:
1357:
1356:
1346:
1329:(10): 5396–402.
1314:
1308:
1307:
1297:
1265:
1259:
1258:
1248:
1238:
1206:
1197:
1196:
1186:
1154:
1148:
1147:
1140:
1134:
1133:
1122:
1116:
1115:
1104:
1098:
1088:
981:
980:
952:
945:
930:
918:
917:
909:
893:
892:
889:RefSeq (protein)
879:
867:
866:
858:
846:
845:
822:
821:
803:
802:
777:
776:
758:
757:
732:
731:
713:
712:
682:
681:
442:
441:
428:
419:
412:
411:
362:ventricular zone
354:genital tubercle
342:
340:Top expressed in
335:
334:
316:
315:
295:
294:
278:
277:
268:
255:
244:
229:
222:
216:
205:
193:
177:
176:
171:
122:
115:
92:
71:
70:
65:
44:
43:
38:
26:
25:
21:Pirriya language
2755:
2754:
2750:
2749:
2748:
2746:
2745:
2744:
2730:
2729:
2728:
2723:
2705:
2575:Other/ungrouped
2570:
2549:
2477:
2422:
2318:DNA glycosylase
2301:Excision repair
2295:
2290:
2260:
2255:
2252:
2246:
2237:
2231:
2217:
2214:
2177:
2172:
1946:(11): 5017–21.
1858:(9): 4896–902.
1661:(29): 19786–9.
1608:(24): 9908–12.
1573:(17): 12182–7.
1473:(3–4): 257–75.
1417:
1415:Further reading
1412:
1411:
1378:(45): 34931–7.
1364:
1360:
1315:
1311:
1266:
1262:
1207:
1200:
1155:
1151:
1142:
1141:
1137:
1124:
1123:
1119:
1106:
1105:
1101:
1089:
1080:
1075:
1051:
1021:
990:View/Edit Mouse
985:View/Edit Human
948:
943:
940:Location (UCSC)
926:
905:
901:
875:
854:
767:ENSG00000136936
660:
529:
488:
479:protein binding
424:
389:
386:proximal tubule
384:
380:
376:
374:muscle of thigh
372:
368:
364:
360:
356:
352:
338:
327:
263:
250:
242:
232:
231:
230:
223:
203:
180:Gene location (
169:XPA - orthologs
131:
118:
111:
80:
58:
24:
17:
12:
11:
5:
2753:
2743:
2742:
2725:
2724:
2722:
2721:
2710:
2707:
2706:
2704:
2703:
2698:
2693:
2688:
2683:
2678:
2677:
2676:
2671:
2666:
2661:
2656:
2651:
2646:
2641:
2626:
2625:
2620:
2610:
2609:
2604:
2599:
2594:
2589:
2584:
2578:
2576:
2572:
2571:
2569:
2568:
2563:
2557:
2555:
2551:
2550:
2548:
2547:
2546:
2545:
2540:
2530:
2525:
2520:
2519:
2518:
2508:
2503:
2502:
2501:
2496:
2485:
2483:
2482:Other pathways
2479:
2478:
2476:
2475:
2470:
2465:
2460:
2455:
2454:
2453:
2443:
2438:
2432:
2430:
2424:
2423:
2421:
2420:
2419:
2418:
2413:
2403:
2402:
2401:
2396:
2391:
2386:
2381:
2376:
2371:
2366:
2361:
2356:
2351:
2346:
2332:
2331:
2330:
2325:
2320:
2305:
2303:
2297:
2296:
2289:
2288:
2281:
2274:
2266:
2257:
2256:
2254:
2253:
2247:
2240:
2238:
2232:
2225:
2222:
2219:
2218:
2213:
2212:
2205:
2198:
2190:
2184:
2183:
2176:
2175:External links
2173:
2171:
2170:
2141:
2121:(3): 1885–90.
2106:
2088:(2): 199–205.
2077:
2048:
2013:
1995:(1–2): 345–8.
1984:
1931:
1893:(11): 5012–6.
1878:
1843:
1813:
1770:
1727:
1693:(6296): 73–6.
1681:
1646:
1593:
1558:
1528:
1496:Human Genetics
1491:
1462:
1428:Human Mutation
1418:
1416:
1413:
1410:
1409:
1358:
1309:
1260:
1221:(11): 5012–6.
1198:
1149:
1135:
1117:
1099:
1077:
1076:
1074:
1071:
1050:
1047:
1020:
1017:
997:
996:
993:
992:
987:
977:
976:
970:
969:
966:
965:
963:
961:
954:
953:
946:
941:
937:
936:
933:
932:
922:
921:
915:
912:
911:
897:
896:
890:
886:
885:
882:
881:
871:
870:
864:
861:
860:
850:
849:
843:
839:
838:
835:
834:
826:
825:
819:
816:
815:
807:
806:
800:
794:
793:
790:
789:
781:
780:
774:
771:
770:
762:
761:
755:
749:
748:
745:
744:
736:
735:
729:
726:
725:
717:
716:
710:
704:
703:
698:
693:
689:
688:
678:
677:
674:
673:
662:
661:
659:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
593:
588:
586:response to UV
583:
578:
573:
568:
563:
558:
553:
548:
543:
537:
535:
531:
530:
528:
527:
522:
517:
512:
507:
502:
496:
494:
490:
489:
487:
486:
481:
476:
471:
466:
461:
455:
453:
449:
448:
438:
437:
434:
433:
430:
429:
421:
420:
409:
403:
402:
399:
398:
395:
394:
391:
390:
388:
387:
383:
382:tail of embryo
379:
375:
371:
367:
363:
359:
355:
351:
347:
344:
343:
332:
329:
328:
326:
323:
320:
319:
312:
311:
303:
292:
286:
285:
282:RNA expression
274:
273:
270:
269:
261:
257:
256:
248:
245:
240:
234:
233:
224:
217:
211:
207:
206:
201:
195:
194:
186:
185:
173:
172:
129:
125:
124:
116:
108:
107:
103:
102:
99:
98:
95:
94:
76:
75:
67:
66:
55:
49:
48:
40:
39:
31:
30:
15:
9:
6:
4:
3:
2:
2752:
2741:
2738:
2737:
2735:
2720:
2712:
2711:
2708:
2702:
2699:
2697:
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2636:
2635:
2631:
2630:FANC proteins
2628:
2627:
2624:
2621:
2619:
2615:
2612:
2611:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2579:
2577:
2573:
2567:
2564:
2562:
2559:
2558:
2556:
2552:
2544:
2541:
2539:
2536:
2535:
2534:
2531:
2529:
2526:
2524:
2521:
2517:
2514:
2513:
2512:
2509:
2507:
2504:
2500:
2497:
2495:
2492:
2491:
2490:
2487:
2486:
2484:
2480:
2474:
2471:
2469:
2466:
2464:
2461:
2459:
2456:
2452:
2451:RecQ helicase
2449:
2448:
2447:
2444:
2442:
2439:
2437:
2434:
2433:
2431:
2429:
2425:
2417:
2414:
2412:
2409:
2408:
2407:
2404:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2341:
2340:
2336:
2333:
2329:
2326:
2324:
2321:
2319:
2316:
2315:
2314:
2310:
2307:
2306:
2304:
2302:
2298:
2294:
2287:
2282:
2280:
2275:
2273:
2268:
2267:
2264:
2250:
2244:
2239:
2235:
2229:
2224:
2223:
2220:
2211:
2206:
2204:
2199:
2197:
2192:
2191:
2188:
2182:
2179:
2178:
2167:
2163:
2159:
2155:
2152:(3): 269–76.
2151:
2147:
2142:
2138:
2134:
2129:
2124:
2120:
2116:
2112:
2107:
2103:
2099:
2095:
2091:
2087:
2083:
2078:
2074:
2070:
2066:
2062:
2058:
2054:
2049:
2045:
2041:
2036:
2031:
2027:
2023:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1990:
1985:
1981:
1977:
1972:
1967:
1962:
1957:
1953:
1949:
1945:
1941:
1937:
1932:
1928:
1924:
1919:
1914:
1909:
1904:
1900:
1896:
1892:
1888:
1884:
1879:
1875:
1871:
1866:
1861:
1857:
1853:
1849:
1844:
1840:
1836:
1832:
1828:
1824:
1820:
1814:
1810:
1806:
1801:
1796:
1792:
1788:
1784:
1780:
1776:
1771:
1767:
1763:
1758:
1753:
1749:
1745:
1741:
1737:
1733:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1682:
1678:
1674:
1669:
1664:
1660:
1656:
1652:
1647:
1643:
1639:
1634:
1629:
1624:
1619:
1615:
1611:
1607:
1603:
1599:
1594:
1590:
1586:
1581:
1576:
1572:
1568:
1564:
1559:
1555:
1551:
1547:
1543:
1540:(2): 203–12.
1539:
1535:
1529:
1525:
1521:
1517:
1513:
1509:
1505:
1501:
1497:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1463:
1459:
1455:
1451:
1447:
1442:
1437:
1433:
1429:
1425:
1420:
1419:
1405:
1401:
1396:
1391:
1386:
1381:
1377:
1373:
1369:
1362:
1354:
1350:
1345:
1340:
1336:
1332:
1328:
1324:
1320:
1313:
1305:
1301:
1296:
1291:
1287:
1283:
1279:
1275:
1271:
1264:
1256:
1252:
1247:
1242:
1237:
1232:
1228:
1224:
1220:
1216:
1212:
1205:
1203:
1194:
1190:
1185:
1180:
1176:
1172:
1168:
1164:
1160:
1153:
1145:
1139:
1131:
1127:
1121:
1113:
1109:
1103:
1096:
1092:
1087:
1085:
1083:
1078:
1070:
1068:
1064:
1060:
1056:
1046:
1044:
1040:
1036:
1034:
1029:
1025:
1016:
1014:
1011:
1007:
1003:
991:
986:
982:
978:
975:
971:
964:
962:
959:
955:
951:
947:
942:
938:
931:
929:
923:
919:
916:
910:
908:
904:
898:
894:
891:
887:
880:
878:
872:
868:
865:
859:
857:
851:
847:
844:
842:RefSeq (mRNA)
840:
833:
832:
827:
823:
820:
814:
813:
808:
804:
801:
799:
795:
788:
787:
782:
778:
775:
769:
768:
763:
759:
756:
754:
750:
743:
742:
737:
733:
730:
724:
723:
718:
714:
711:
709:
705:
702:
699:
697:
694:
690:
687:
683:
679:
672:
668:
663:
657:
654:
652:
649:
647:
644:
642:
639:
637:
636:UV protection
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
547:
544:
542:
539:
538:
536:
533:
532:
526:
523:
521:
518:
516:
513:
511:
508:
506:
503:
501:
498:
497:
495:
492:
491:
485:
482:
480:
477:
475:
472:
470:
467:
465:
462:
460:
457:
456:
454:
451:
450:
447:
446:Gene ontology
443:
439:
427:
422:
418:
413:
410:
408:
404:
396:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
348:
345:
341:
336:
333:
324:
321:
317:
314:
313:
310:
308:
304:
302:
301:
297:
296:
293:
291:
287:
283:
279:
275:
267:
262:
258:
254:
249:
239:
235:
228:
221:
215:
208:
200:
196:
192:
187:
183:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
126:
121:
114:
109:
104:
93:
91:
87:
83:
77:
72:
69:
68:
64:
61:
54:
50:
45:
41:
37:
32:
27:
22:
2633:
2614:DNA helicase
2597:8-Oxoguanine
2566:SOS response
2446:RecF pathway
2399:Excinuclease
2343:
2248:
2233:
2149:
2145:
2118:
2114:
2085:
2081:
2059:(2): 341–2.
2056:
2052:
2025:
2021:
1992:
1988:
1943:
1939:
1890:
1886:
1855:
1851:
1825:(2): 486–9.
1822:
1818:
1785:(3): 960–6.
1782:
1778:
1739:
1735:
1690:
1686:
1658:
1654:
1605:
1601:
1570:
1566:
1537:
1533:
1502:(6): 603–7.
1499:
1495:
1470:
1466:
1431:
1427:
1375:
1371:
1361:
1326:
1322:
1312:
1280:(3): 960–6.
1277:
1273:
1263:
1218:
1214:
1166:
1162:
1152:
1138:
1129:
1120:
1111:
1102:
1052:
1049:Interactions
1038:
1037:
1022:
1009:
1001:
1000:
925:
907:NP_001341904
900:
874:
853:
829:
810:
784:
765:
739:
720:
700:
695:
366:right kidney
305:
298:
128:External IDs
79:
2740:Human genes
2216:PDB gallery
2028:(1): 1–14.
1434:(1): 9–22.
1028:DNA damages
520:nucleoplasm
474:DNA binding
350:granulocyte
264:46,196,311
251:46,155,347
106:Identifiers
2554:Regulation
2533:Photolyase
2293:DNA repair
1800:1765/60251
1295:1765/60251
1169:: 123–35.
1097:, May 2017
1073:References
631:DNA repair
309:(ortholog)
149:HomoloGene
2374:XPG/ERCC5
2359:XPD/ERCC2
1395:1765/3168
928:NP_035858
903:NP_000371
877:NM_011728
856:NM_000380
686:Orthologs
525:cytoplasm
157:GeneCards
2734:Category
2719:Category
2369:XPF/DDB1
2364:XPE/DDB1
2082:Genomics
1819:Genomics
1524:36814493
1487:10946233
1458:24148589
1450:10447254
1404:10944529
1193:27247238
1093:–
1055:interact
1019:Function
974:Wikidata
665:Sources:
2561:SOS box
2313:AP site
2166:9653453
2137:8999876
2102:8954802
2073:8543191
2044:8504220
2009:8294029
1980:8197175
1948:Bibcode
1927:8197174
1895:Bibcode
1874:7876263
1839:7835901
1809:7598728
1766:7565690
1723:4346999
1715:2234061
1695:Bibcode
1677:1918083
1642:1702221
1610:Bibcode
1589:1601884
1554:1372103
1516:1339397
1353:7565690
1304:7598728
1255:8197174
1223:Bibcode
1184:4958585
1095:Ensembl
1006:protein
798:UniProt
753:Ensembl
692:Species
671:QuickGO
515:nucleus
284:pattern
113:Aliases
2686:FANCD2
2681:FANCD1
2441:RecBCD
2394:RAD23B
2389:RAD23A
2164:
2135:
2100:
2071:
2042:
2007:
1978:
1968:
1925:
1915:
1872:
1837:
1807:
1764:
1757:230789
1754:
1721:
1713:
1687:Nature
1675:
1640:
1630:
1587:
1552:
1522:
1514:
1485:
1456:
1448:
1402:
1351:
1344:230789
1341:
1302:
1253:
1243:
1191:
1181:
960:search
958:PubMed
831:Q64267
812:P23025
708:Entrez
407:BioGPS
378:embryo
137:611153
2701:FANCN
2696:FANCJ
2691:FANCI
2674:FANCM
2669:FANCL
2664:FANCG
2659:FANCF
2654:FANCE
2649:FANCC
2644:FANCB
2639:FANCA
2499:ERCC8
2494:ERCC6
2458:RAD51
2379:ERCC1
1971:43921
1918:43920
1719:S2CID
1633:55283
1520:S2CID
1454:S2CID
1246:43920
1059:ERCC1
1057:with
1033:ERCC1
1004:is a
741:22590
701:Mouse
696:Human
667:Amigo
307:Mouse
300:Human
247:Start
182:Mouse
153:37298
145:99135
2587:PcrA
2543:CRY2
2538:CRY1
2473:LexA
2468:Slx4
2463:Sgs1
2436:RecA
2416:MSH2
2411:MLH1
2339:ERCC
2249:1xpa
2234:1d4u
2162:PMID
2133:PMID
2098:PMID
2069:PMID
2053:Gene
2040:PMID
2005:PMID
1989:Gene
1976:PMID
1923:PMID
1870:PMID
1835:PMID
1805:PMID
1762:PMID
1711:PMID
1673:PMID
1638:PMID
1585:PMID
1550:PMID
1512:PMID
1483:PMID
1446:PMID
1400:PMID
1349:PMID
1300:PMID
1251:PMID
1189:PMID
1067:XAB2
1065:and
1031:the
1013:gene
722:7507
290:Bgee
238:Band
199:Chr.
133:OMIM
90:2JNW
86:1XPA
82:1D4U
63:RCSB
60:PDBe
2623:WRN
2618:BLM
2582:Ogt
2384:RPA
2354:XPC
2349:XPB
2344:XPA
2154:doi
2150:407
2123:doi
2119:272
2090:doi
2061:doi
2057:166
2030:doi
1997:doi
1993:136
1966:PMC
1956:doi
1913:PMC
1903:doi
1860:doi
1856:270
1827:doi
1795:hdl
1787:doi
1783:211
1752:PMC
1744:doi
1703:doi
1691:348
1663:doi
1659:266
1628:PMC
1618:doi
1575:doi
1571:267
1542:doi
1538:273
1504:doi
1475:doi
1471:460
1436:doi
1390:hdl
1380:doi
1376:275
1339:PMC
1331:doi
1290:hdl
1282:doi
1278:211
1241:PMC
1231:doi
1179:PMC
1171:doi
1039:Xpa
1010:XPA
944:n/a
325:n/a
260:End
165:OMA
161:XPA
141:MGI
120:XPA
53:PDB
29:XPA
2736::
2632::
2616::
2516:Ku
2160:.
2148:.
2131:.
2117:.
2113:.
2096:.
2086:38
2084:.
2067:.
2055:.
2038:.
2026:38
2024:.
2020:.
2003:.
1991:.
1974:.
1964:.
1954:.
1944:91
1942:.
1938:.
1921:.
1911:.
1901:.
1891:91
1889:.
1885:.
1868:.
1854:.
1850:.
1833:.
1823:23
1821:.
1803:.
1793:.
1781:.
1777:.
1760:.
1750:.
1740:15
1738:.
1734:.
1717:.
1709:.
1701:.
1689:.
1671:.
1657:.
1653:.
1636:.
1626:.
1616:.
1606:87
1604:.
1600:.
1583:.
1569:.
1565:.
1548:.
1536:.
1518:.
1510:.
1500:88
1498:.
1481:.
1469:.
1452:.
1444:.
1432:14
1430:.
1426:.
1398:.
1388:.
1374:.
1370:.
1347:.
1337:.
1327:15
1325:.
1321:.
1298:.
1288:.
1276:.
1272:.
1249:.
1239:.
1229:.
1219:91
1217:.
1213:.
1201:^
1187:.
1177:.
1167:44
1165:.
1161:.
1128:.
1110:.
1081:^
1069:.
1061:,
1015:.
669:/
266:bp
253:bp
163:;
159::
155:;
151::
147:;
143::
139:;
135::
88:,
84:,
2337:/
2311:/
2285:e
2278:t
2271:v
2209:e
2202:t
2195:v
2168:.
2156::
2139:.
2125::
2104:.
2092::
2075:.
2063::
2046:.
2032::
2011:.
1999::
1982:.
1958::
1950::
1929:.
1905::
1897::
1876:.
1862::
1841:.
1829::
1811:.
1797::
1789::
1768:.
1746::
1725:.
1705::
1697::
1679:.
1665::
1644:.
1620::
1612::
1591:.
1577::
1556:.
1544::
1526:.
1506::
1489:.
1477::
1460:.
1438::
1406:.
1392::
1382::
1355:.
1333::
1306:.
1292::
1284::
1257:.
1233::
1225::
1195:.
1173::
1146:.
1132:.
1114:.
184:)
167::
23:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
