234:
211:
133:
108:
1097:
891:
861:
240:
139:
949:
1118:
956:
Vexin is 207 amino acids long, which equates to a molecular weight of 22.6 kdal. The isoelectric point of the protein is 10.42 which indicates the pH of the protein is basic. Vexin does contain a domain of unknown function (DUF4648) and is a part of the
1108:
Vexin is predicted to be a nuclear protein, given the classical nuclear localization signal found at amino acids Lys191 to Lys193. Vexin does not contain any transmembrane domains or signal peptides suggesting that it is an intracellular protein.
1413:
918:
The N-terminus and C-terminus are highly conserved regions across both distant and close orthologs. The orthologs of vexin all show conservation of the SH3 protein domain family as well as a domain of unknown function (DUF4648).
1132:
has shown to be ubiquitously expressed in the body. The gene is expressed in 13 different types of tissue throughout the body, with the brain, spinal cord and nerves showing elevated expression of the gene. Specifically, the
247:
146:
1168:
in humans. The gene has been researched in connection with estrogen receptor 1- enhancer (ESR1), whose expression determines if a breast cancer patient receives endocrine therapy. It is predicted that
977:
compared to the composition of the average human protein. Vexin does contain several regions of positively charged runs and has a high concentration of basic amino acids.
910:, which diverged from the human version of the gene an estimated 482.9 million years ago. The gene has not been found in any plants, fungi or single celled organisms.
1141:
areas of the brain show high levels of expression. In addition to healthy tissue, vexin is also found in several disease states. These disease states include
540:
559:
69:
985:
Vexin is predicted to undergo several types of post translational modifications. With a high degree of certainty, it is predicted that vexin undergoes
1231:
1249:
935:
does not have any alternative mRNA splice variants. The mature mRNA is approximately 3,741 base pairs in length and contains six exons.
759:
902:
Vexin is found in all classes of vertebrates, including mammals, birds, fish, reptiles and amphibians. The most distant ortholog of
850:
766:
1214:
1696:
1054:
Ser25, Ser90, Ser97, Ser102, Ser113, Ser122, Ser126, Ser128 Ser130, Ser148, Ser194, Thr78, Thr101, Thr125, Thr134, Thr155
961:, which is known to bind to proline-rich ligands. The secondary and tertiary structure of this protein is not well known.
1193:
1068:
Ser22, Ser25, Ser26, Ser34, Ser35, Ser97, Ser122, Ser126, Ser130, Ser194, Thr78, Thr83, Thr138, Tyr50, Tyr158, Tyr196
1701:
1549:"Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors"
233:
1172:
has ESR1 enhancer regions that become hypermethylated and promote acquired endocrine resistance in breast cancer.
1218:
1197:
210:
604:
1466:
585:
132:
107:
246:
145:
854:
44:
239:
138:
57:
1592:"DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer"
1495:"DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer"
742:
721:
695:
674:
990:
1313:
1138:
907:
1646:
121:
8:
77:
1650:
1669:
1634:
1616:
1591:
1590:
Stone A, Zotenko E, Locke WJ, Korbie D, Millar EK, Pidsley R, et al. (July 2015).
1573:
1548:
1547:
de Leeuw CN, Dyka FM, Boye SL, Laprise S, Zhou M, Chou AY, et al. (January 2014).
1519:
1494:
1493:
Stone A, Zotenko E, Locke WJ, Korbie D, Millar EK, Pidsley R, et al. (July 2015).
952:
Location of the domain of unknown function and nuclear localization signal along vexin.
81:
1674:
1621:
1578:
1524:
37:
61:
1664:
1654:
1611:
1603:
1568:
1560:
1514:
1506:
845:
is found along the plus strand of chromosome 8. The entire gene is 58,522 bp long.
326:
257:
201:
156:
1659:
1096:
1062:
1048:
994:
301:
85:
1254:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1236:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1142:
402:
1071:
Regulates protein function, cell signaling and enzymatic functions of protein
1690:
1165:
974:
890:
860:
462:
340:
1678:
1625:
1582:
1528:
1278:
1076:
998:
319:
98:
806:
801:
1035:
1002:
829:
is found to be highly expressed in regions of the brain and spinal cord.
649:
630:
1607:
1564:
1510:
1437:
1370:
1121:
Image from Allen Brain Atlas shows the areas of elevated expression of
958:
218:
115:
65:
1134:
1022:
986:
504:
285:
272:
184:
171:
73:
1085:
Plays a role in nuclear-cytosolic transport, acts as binding site.
970:
790:
1635:"Functionally enigmatic genes: a case study of the brain ignorome"
948:
616:
571:
1146:
1117:
774:
526:
1438:"ISH Data :: Allen Brain Atlas: Developing Mouse Brain"
1341:
1633:
Pandey AK, Lu L, Wang X, Homayouni R, Williams RW (2014).
1389:
1104:
depicts predicted post-translational modification sites.
309:
1589:
1546:
1492:
1043:
Mediates protein stability, sorting and localization.
1632:
1553:
Molecular
Therapy: Methods & Clinical Development
1149:, kidney tumors, liver tumors, and germ cell tumors.
474:
48:, chromosome 8 open reading frame 46, C8orf46, vexin
1390:"ExPASy: SIB Bioinformatics Resource Portal - Home"
980:
1210:
1208:
1206:
1189:
1187:
1185:
1057:Regulates transcription and translation factors.
894:Phylogentic tree of select orthologs of the gene
256:
155:
1688:
1203:
1182:
882:No human paralogs for VXN have been identified
16:Protein-coding gene in the species Homo sapiens
1215:GRCm38: Ensembl release 89: ENSMUSG00000067879
1471:National Center for Biotechnology Information
1414:"Overview of Post-Translational Modification"
1287:National Center for Biotechnology Information
1027:Lys33, Lys41, Lys124, Lys152. Lys153, Lys193
1194:GRCh38: Ensembl release 89: ENSG00000169085
1023:Glycation of Epsilon Amino Groups of Lysine
1668:
1658:
1615:
1572:
1518:
1153:is only expressed in infants and adults.
868:along the forward strand of chromosome 8.
1342:"TimeTree :: The Timescale of Life"
1156:
1116:
1095:
947:
898:. Estimated date of divergence is shown.
889:
859:
1091:
1030:Impairs enzymatic function of protein.
851:alcohol dehydrogenase iron containing 1
1689:
1488:
1486:
1461:
1459:
1457:
943:
913:
261:
222:
217:
160:
119:
114:
1384:
1382:
1380:
1365:
1363:
1361:
1308:
1306:
1304:
1302:
1273:
1271:
1269:
1267:
1265:
1263:
13:
1539:
1483:
1454:
927:
14:
1713:
1377:
1358:
1299:
1260:
993:, serine, threonine and tyrosine
981:Post-translational modifications
449:lumbar subsegment of spinal cord
245:
238:
232:
209:
144:
137:
131:
106:
1430:
1406:
1334:
1242:
1224:
1036:Initial Methionine Acetylation
964:
463:More reference expression data
421:Region I of hippocampus proper
1:
1442:developingmouse.brain-map.org
1175:
1112:
230:
129:
1660:10.1371/journal.pone.0088889
969:Vexin is considered rich in
885:
7:
1697:Genes on human chromosome 8
877:
872:
837:
10:
1718:
1100:Conceptual translation of
938:
1467:"EST Profile - Hs.268869"
1250:"Mouse PubMed Reference:"
1232:"Human PubMed Reference:"
1164:has been associated with
855:Myb proto-oncogene like 1
805:
800:
796:
789:
773:
754:
739:
735:
718:
714:
707:
692:
688:
671:
667:
660:
647:
643:
628:
624:
615:
602:
598:
583:
579:
570:
557:
553:
538:
534:
525:
510:
503:
499:
487:
482:
473:
460:
409:
400:
367:anterior cingulate cortex
347:
338:
308:
300:
296:
279:
266:
229:
208:
199:
195:
178:
165:
128:
105:
96:
92:
55:
52:
42:
35:
30:
26:
21:
1702:Uncharacterized proteins
1418:Thermo Fisher Scientific
1371:"SDSC Biology Workbench"
821:is a protein encoded by
1001:and initial methionine
922:
832:
760:Chr 8: 66.49 – 66.52 Mb
1126:
1105:
953:
899:
869:
433:superior frontal gyrus
1596:Nature Communications
1499:Nature Communications
1157:Clinical significance
1139:hippocampal formation
1120:
1099:
1011:Type of Modification
951:
893:
864:Gene neighborhood of
863:
429:primary visual cortex
1092:Subcellular location
1014:Amino Acid Position
767:Chr 1: 9.67 – 9.7 Mb
413:primary motor cortex
224:Chromosome 1 (mouse)
122:Chromosome 8 (human)
1651:2014PLoSO...988889P
908:Callorhinchus milli
1608:10.1038/ncomms8758
1565:10.1038/mtm.2013.5
1511:10.1038/ncomms8758
1127:
1106:
1017:Impact on Protein
954:
944:General properties
914:Homologous domains
900:
870:
605:ENSMUSG00000067879
445:hippocampus proper
371:right frontal lobe
1279:"VXN vexin [
1089:
1088:
959:SH3 domain family
816:
815:
812:
811:
785:
784:
750:
749:
729:
728:
703:
702:
682:
681:
656:
655:
637:
636:
611:
610:
592:
591:
566:
565:
547:
546:
495:
494:
491:
490:
469:
468:
456:
455:
417:prefrontal cortex
394:
393:
359:prefrontal cortex
292:
291:
191:
190:
1709:
1682:
1672:
1662:
1629:
1619:
1586:
1576:
1533:
1532:
1522:
1490:
1481:
1480:
1478:
1477:
1463:
1452:
1451:
1449:
1448:
1434:
1428:
1427:
1425:
1424:
1410:
1404:
1403:
1401:
1400:
1386:
1375:
1374:
1367:
1356:
1355:
1353:
1352:
1338:
1332:
1331:
1329:
1328:
1310:
1297:
1296:
1294:
1293:
1275:
1258:
1257:
1246:
1240:
1239:
1228:
1222:
1212:
1201:
1191:
1008:
1007:
987:lysine glycation
798:
797:
769:
762:
745:
733:
732:
724:
712:
711:
708:RefSeq (protein)
698:
686:
685:
677:
665:
664:
641:
640:
622:
621:
596:
595:
577:
576:
551:
550:
532:
531:
501:
500:
480:
479:
465:
405:
403:Top expressed in
398:
397:
343:
341:Top expressed in
336:
335:
315:
314:
298:
297:
288:
275:
264:
249:
242:
236:
225:
213:
197:
196:
187:
174:
163:
148:
141:
135:
124:
110:
94:
93:
88:
47:
40:
19:
18:
1717:
1716:
1712:
1711:
1710:
1708:
1707:
1706:
1687:
1686:
1685:
1542:
1540:Further reading
1537:
1536:
1491:
1484:
1475:
1473:
1465:
1464:
1455:
1446:
1444:
1436:
1435:
1431:
1422:
1420:
1412:
1411:
1407:
1398:
1396:
1388:
1387:
1378:
1369:
1368:
1359:
1350:
1348:
1340:
1339:
1335:
1326:
1324:
1312:
1311:
1300:
1291:
1289:
1277:
1276:
1261:
1248:
1247:
1243:
1230:
1229:
1225:
1213:
1204:
1192:
1183:
1178:
1159:
1115:
1094:
1082:Lys141, Lys195
1063:Phosphorylation
1049:O-glycosylation
995:phosphorylation
991:O-glycosylation
983:
967:
946:
941:
930:
928:Splice variants
925:
916:
888:
880:
875:
840:
835:
807:View/Edit Mouse
802:View/Edit Human
765:
758:
755:Location (UCSC)
741:
720:
694:
673:
586:ENSG00000169085
461:
452:
447:
443:
441:cingulate gyrus
439:
435:
431:
427:
423:
419:
415:
401:
390:
385:
381:
379:caudate nucleus
377:
373:
369:
365:
363:cingulate gyrus
361:
357:
355:Brodmann area 9
353:
339:
283:
270:
262:
252:
251:
250:
243:
223:
200:Gene location (
182:
169:
161:
151:
150:
149:
142:
120:
97:Gene location (
86:VXN - orthologs
56:
43:
36:
17:
12:
11:
5:
1715:
1705:
1704:
1699:
1684:
1683:
1630:
1587:
1543:
1541:
1538:
1535:
1534:
1482:
1453:
1429:
1405:
1376:
1357:
1333:
1298:
1283:(human) ]"
1259:
1241:
1223:
1202:
1180:
1179:
1177:
1174:
1158:
1155:
1143:chondrosarcoma
1114:
1111:
1093:
1090:
1087:
1086:
1083:
1080:
1073:
1072:
1069:
1066:
1059:
1058:
1055:
1052:
1045:
1044:
1041:
1038:
1032:
1031:
1028:
1025:
1019:
1018:
1015:
1012:
982:
979:
973:, and poor in
966:
963:
945:
942:
940:
937:
929:
926:
924:
921:
915:
912:
887:
884:
879:
876:
874:
871:
849:is flanked by
839:
836:
834:
831:
814:
813:
810:
809:
804:
794:
793:
787:
786:
783:
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778:
771:
770:
763:
756:
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751:
748:
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736:
730:
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715:
709:
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619:
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589:
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574:
568:
567:
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535:
529:
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522:
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492:
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488:
485:
484:
477:
471:
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466:
458:
457:
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453:
451:
450:
446:
442:
438:
434:
430:
426:
422:
418:
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410:
407:
406:
395:
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389:
388:
384:
380:
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372:
368:
364:
360:
356:
352:
348:
345:
344:
332:
331:
323:
312:
306:
305:
302:RNA expression
294:
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276:
268:
265:
260:
254:
253:
244:
237:
231:
227:
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206:
205:
193:
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175:
167:
164:
159:
153:
152:
143:
136:
130:
126:
125:
118:
112:
111:
103:
102:
90:
89:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
1714:
1703:
1700:
1698:
1695:
1694:
1692:
1680:
1676:
1671:
1666:
1661:
1656:
1652:
1648:
1645:(2): e88889.
1644:
1640:
1636:
1631:
1627:
1623:
1618:
1613:
1609:
1605:
1601:
1597:
1593:
1588:
1584:
1580:
1575:
1570:
1566:
1562:
1558:
1554:
1550:
1545:
1544:
1530:
1526:
1521:
1516:
1512:
1508:
1504:
1500:
1496:
1489:
1487:
1472:
1468:
1462:
1460:
1458:
1443:
1439:
1433:
1419:
1415:
1409:
1395:
1391:
1385:
1383:
1381:
1372:
1366:
1364:
1362:
1347:
1343:
1337:
1323:
1319:
1318:Gene - Vexin"
1317:
1309:
1307:
1305:
1303:
1288:
1284:
1282:
1274:
1272:
1270:
1268:
1266:
1264:
1255:
1251:
1245:
1237:
1233:
1227:
1220:
1216:
1211:
1209:
1207:
1199:
1195:
1190:
1188:
1186:
1181:
1173:
1171:
1167:
1166:breast cancer
1163:
1154:
1152:
1148:
1144:
1140:
1136:
1131:
1125:in the brain.
1124:
1119:
1110:
1103:
1098:
1084:
1081:
1078:
1075:
1074:
1070:
1067:
1064:
1061:
1060:
1056:
1053:
1050:
1047:
1046:
1042:
1039:
1037:
1034:
1033:
1029:
1026:
1024:
1021:
1020:
1016:
1013:
1010:
1009:
1006:
1004:
1000:
996:
992:
988:
978:
976:
975:phenylalanine
972:
962:
960:
950:
936:
934:
920:
911:
909:
905:
897:
892:
883:
867:
862:
858:
856:
852:
848:
844:
830:
828:
824:
820:
808:
803:
799:
795:
792:
788:
781:
779:
776:
772:
768:
764:
761:
757:
753:
746:
744:
738:
734:
731:
725:
723:
717:
713:
710:
706:
699:
697:
691:
687:
684:
678:
676:
670:
666:
663:
661:RefSeq (mRNA)
659:
652:
651:
646:
642:
639:
633:
632:
627:
623:
620:
618:
614:
607:
606:
601:
597:
594:
588:
587:
582:
578:
575:
573:
569:
562:
561:
556:
552:
549:
543:
542:
537:
533:
530:
528:
524:
521:
518:
516:
513:
509:
506:
502:
498:
486:
481:
478:
476:
472:
464:
459:
448:
444:
440:
436:
432:
428:
425:visual cortex
424:
420:
416:
412:
411:
408:
404:
399:
396:
386:
382:
378:
374:
370:
366:
362:
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354:
350:
349:
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342:
337:
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330:
328:
324:
322:
321:
317:
316:
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311:
307:
303:
299:
295:
287:
282:
278:
274:
269:
259:
255:
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241:
235:
228:
220:
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212:
207:
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198:
194:
186:
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177:
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168:
158:
154:
147:
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127:
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117:
113:
109:
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100:
95:
91:
87:
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79:
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71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1642:
1638:
1599:
1595:
1556:
1552:
1502:
1498:
1474:. Retrieved
1470:
1445:. Retrieved
1441:
1432:
1421:. Retrieved
1417:
1408:
1397:. Retrieved
1393:
1349:. Retrieved
1346:timetree.org
1345:
1336:
1325:. Retrieved
1321:
1315:
1290:. Retrieved
1286:
1281:Homo sapiens
1280:
1253:
1244:
1235:
1226:
1169:
1161:
1160:
1150:
1129:
1128:
1122:
1107:
1101:
984:
968:
955:
932:
931:
917:
903:
901:
895:
881:
865:
846:
842:
841:
826:
822:
818:
817:
740:
719:
693:
672:
648:
629:
603:
584:
558:
539:
519:
514:
387:hypothalamus
325:
318:
53:External IDs
1077:SUMOylation
1003:acetylation
999:SUMOylation
965:Composition
263:1|1 A2
183:66,518,524
170:66,493,520
31:Identifiers
1691:Categories
1476:2016-05-09
1447:2016-05-09
1423:2016-05-09
1399:2016-04-25
1394:expasy.org
1351:2016-05-09
1327:2016-04-25
1292:2021-01-06
1221:, May 2017
1200:, May 2017
1176:References
1113:Expression
351:C1 segment
329:(ortholog)
284:9,697,368
271:9,671,424
66:HomoloGene
1322:GeneCards
1135:isocortex
886:Orthologs
743:NP_848486
722:NP_689978
696:NM_178399
675:NM_152765
505:Orthologs
437:subiculum
74:GeneCards
1679:24523945
1639:PLOS ONE
1626:26169690
1602:: 7758.
1583:24761428
1529:26169690
1505:: 7758.
1217:–
1196:–
971:arginine
878:Paralogs
873:Homology
838:Location
791:Wikidata
375:amygdala
1670:3921226
1647:Bibcode
1617:4510968
1574:3992516
1520:4510968
1219:Ensembl
1198:Ensembl
939:Protein
617:UniProt
572:Ensembl
511:Species
383:putamen
304:pattern
62:1924232
38:Aliases
1677:
1667:
1624:
1614:
1581:
1571:
1527:
1517:
1147:glioma
1079:sites
1065:sites
1051:sites
906:is in
825:gene.
777:search
775:PubMed
650:Q8BG31
631:Q8TAG6
541:254778
527:Entrez
475:BioGPS
162:8q13.1
1559:: 5.
1040:Met1
819:Vexin
560:76982
520:Mouse
515:Human
327:Mouse
320:Human
267:Start
202:Mouse
166:Start
99:Human
70:17666
1675:PMID
1622:PMID
1579:PMID
1525:PMID
1137:and
923:mRNA
853:and
833:Gene
310:Bgee
258:Band
219:Chr.
157:Band
116:Chr.
1665:PMC
1655:doi
1612:PMC
1604:doi
1569:PMC
1561:doi
1515:PMC
1507:doi
1316:VXN
1170:VXN
1162:VXN
1151:VXN
1130:VXN
1123:VXN
1102:VXN
933:VXN
904:VXN
896:VXN
866:VXN
847:VXN
843:VXN
827:VXN
823:VXN
483:n/a
280:End
179:End
82:OMA
78:VXN
58:MGI
45:VXN
22:VXN
1693::
1673:.
1663:.
1653:.
1641:.
1637:.
1620:.
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1598:.
1594:.
1577:.
1567:.
1555:.
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1523:.
1513:.
1501:.
1497:.
1485:^
1469:.
1456:^
1440:.
1416:.
1392:.
1379:^
1360:^
1344:.
1320:.
1301:^
1285:.
1262:^
1252:.
1234:.
1205:^
1184:^
1145:,
1005:.
997:,
989:,
857:.
286:bp
273:bp
185:bp
172:bp
80:;
76::
72:;
68::
64:;
60::
1681:.
1657::
1649::
1643:9
1628:.
1606::
1600:6
1585:.
1563::
1557:1
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1509::
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204:)
101:)
84::
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