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Toll-like receptor 6

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in some populations may be associated with Ser249Pro polymorphism, also present in the extracellular domain of the encoded protein. On the other hand, a protective SNP also exists - S249P is possibly liked to protection from bronchial asthma and resistance from asthma in children.
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After ligand recognition, TLR6 receptor dimerizes with TLR2. Ligand-mediated dimerization is crucial for recruiting the adaptor proteins, which are necessary for transmitting the signal inside the cell. TLR2/6 heterodimer, just as most of the Toll-like receptors, generally induces
50: 1296:(PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with 310: 209: 1268:
intracellular signalling pathway is activated, leading to a pro-inflammatory cytokine production and activation of innate immune response. TLR6 has also been designated as
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have been reported. Moreover, TLR2/6 is known to bind one protozoan ligand – lipopeptidophosphoglycan. TLR2/6 can also be activated by synthetic lipopeptides, such as Pam
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Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, et al. (April 1999). "TLR6: A novel member of an expanding toll-like receptor family".
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Unlike TLR2/1 heterodimer, which recognizes triacylated lipopeptides, the TLR2/6 heterodimer is known to be specific for diacylated lipopeptides such as
951: 932: 132: 4189: 3003: 2130: 1551: 1533: 2983: 1288:(TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from 3845: 2169: 2145: 2064: 1171: 1178: 1611: 3576: 3564: 3342: 1293: 3628: 3623: 3569: 3349: 1516: 4404: 4399: 3082: 3008: 2138: 47: 2076: 4182: 4111: 4106: 4101: 4096: 3023: 1495: 4315: 4300: 4076: 296: 3312: 1394: 3880: 3374: 3060: 1520: 1499: 273: 4175: 3519: 3055: 1462: 1356:. It is also known that TLR2/6 binds some viral products, among them hepatitis C core and NS3 protein from the 996: 2160: 4016: 3488: 3483: 3428: 3162: 2611: 977: 4409: 3710: 3433: 1249: 195: 170: 112: 3028: 1683:"Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice" 3740: 2165: 1874:"Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling" 1273: 309: 208: 1925:"Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs" 2606: 302: 201: 99: 3790: 2685: 2058: 1466: 1154: 1150: 1099: 1095: 1070: 120: 3754: 2054: 1146: 1125: 1091: 1066: 3097: 3092: 3087: 3077: 2384: 2312: 1349: 1301: 1257: 1817:"Identification of TLR2/TLR6 signalling lactic acid bacteria for supporting immune regulation" 1732:"Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer" 1681:
Duggan JM, You D, Cleaver JO, Larson DT, Garza RJ, Guzmán Pruneda FA, et al. (May 2011).
4305: 4269: 4264: 2441: 2359: 1393:(NF-κB), resulting in the production of pro-inflammatory cytokines. But MyD88 also activates 4259: 4254: 4249: 4239: 4234: 4229: 4224: 4219: 4167: 3678: 3391: 1828: 1465:(SNP) in the extracellular leucine rich repeat domain is associated with susceptibility to 1398: 1297: 1253: 184: 1776:"Toll-like receptor polymorphism in host immune response to infectious diseases: A review" 1390: 140: 8: 4198: 3705: 3524: 2082: 2070: 1832: 4279: 4274: 4211: 4202: 3112: 2846: 1990: 1965: 1900: 1873: 1849: 1816: 1707: 1682: 1658: 1631: 1414: 1285: 1245: 144: 1582: 866: 861: 856: 851: 846: 841: 836: 831: 826: 821: 816: 811: 806: 801: 796: 791: 786: 781: 776: 771: 766: 761: 756: 751: 746: 741: 736: 731: 726: 721: 716: 711: 695: 690: 685: 680: 675: 670: 665: 660: 655: 650: 645: 629: 624: 619: 614: 609: 604: 599: 594: 589: 2119: 2110: 2098: 2089: 2035: 2031: 1995: 1946: 1905: 1854: 1797: 1753: 1712: 1663: 1586: 1401:
have been reported to stimulate immune regulation via TLR2/6, leading to tolerogenic
1389:-dependent intracellular signalling pathway, which leads to nuclear translocation of 1345: 92: 40: 124: 3885: 3618: 3539: 3102: 2295: 2221: 2027: 1985: 1977: 1936: 1895: 1885: 1844: 1836: 1787: 1743: 1702: 1694: 1653: 1643: 1578: 389: 320: 264: 219: 3945: 2481: 2476: 2399: 1748: 1731: 1426: 1361: 364: 148: 1966:"A TLR6 polymorphism is associated with increased risk of Legionnaires' disease" 1941: 1924: 1556:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, et al. (December 2009).
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leading to higher resistance against lung infection have also been reported.
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or macrophage-activating lipopeptide (MALP2), found on the cell membrane of
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positive regulation of cytokine production involved in inflammatory response
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to humans and share structural and functional similarities. They recognize
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and several fungal cell wall saccharides. After dimerizing with TLR2, the
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Ren C, Zhang Q, de Haan BJ, Zhang H, Faas MM, de Vos P (October 2016).
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cellular response to oxidised low-density lipoprotein particle stimulus
281: 178: 128: 1840: 1792: 1775: 1256:(TLR2). Its ligands include multiple diacyl lipopeptides derived from 69: 3835: 3830: 3825: 3815: 3810: 3805: 3800: 1438: 1430: 896: 348: 335: 247: 234: 136: 4141: 4041: 3855: 3840: 3043: 3038: 2946: 2636: 1964:
Misch EA, Verbon A, Prins JM, Skerrett SJ, Hawn TR (October 2013).
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positive regulation of reactive oxygen species biosynthetic process
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positive regulation of NF-kappaB transcription factor activity
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negative regulation of toll-like receptor 2 signaling pathway
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Overview of all the structural information available in the
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Overview of all the structural information available in the
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positive regulation of oxidative stress-induced neuron death
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secretion, instead of pro-inflammatory cytokine secretion.
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TLR6 has been shown to interact in a heterodimer form with
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Lien E, Ingalls RR (January 2002). "Toll-like receptors".
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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positive regulation of NLRP3 inflammasome complex assembly
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Toll-like receptor 2-Toll-like receptor 6 protein complex
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positive regulation of nitric oxide biosynthetic process
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Yeh DW, Huang LR, Chen YW, Huang CF, Chuang TH (2016).
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Oliveira-Nascimento L, Massari P, Wetzler LM (2012).
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The protein encoded by this gene is a member of the
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MyD88-dependent toll-like receptor signaling pathway
1252:(PRR) family. TLR6 acts in a heterodimer form with 827:
TRIF-dependent toll-like receptor signaling pathway
1512: 1510: 1508: 1491: 1489: 1487: 1871: 727:cellular response to diacyl bacterial lipopeptide 319: 218: 4391: 1774:Mukherjee S, Huda S, Sinha Babu SP (July 2019). 732:activation of NF-kappaB-inducing kinase activity 1505: 1484: 1376:or Fibroblast–stimulating lipopeptide (FSL-1). 1729: 1517:GRCm38: Ensembl release 89: ENSMUSG00000051498 757:toll-like receptor TLR6:TLR2 signaling pathway 4183: 2146: 1244:. TLR6 is a transmembrane protein, member of 1865: 1808: 1632:"The Role of TLR2 in Infection and Immunity" 832:positive regulation of macrophage activation 2017: 1922: 1674: 1562: 1496:GRCh38: Ensembl release 89: ENSG00000174130 4190: 4176: 2153: 2139: 722:positive regulation of JUN kinase activity 2170:list of human clusters of differentiation 2057:at the U.S. National Library of Medicine 1989: 1940: 1899: 1889: 1848: 1791: 1747: 1706: 1657: 1647: 1332:. Synergistic interactions of TLR2/6 and 762:detection of diacyl bacterial lipopeptide 600:transmembrane signaling receptor activity 1612:"Entrez Gene: TLR6 toll-like receptor 6" 1456: 1300:(TLR2) to mediate cellular response to 4392: 1923:Olson JK, Miller SD (September 2004). 1413:In human, TLR6 is highly expressed in 1294:pathogen-associated molecular patterns 817:positive regulation of gene expression 737:toll-like receptor 6 signaling pathway 4171: 2134: 1769: 1767: 1397:(MAPKs). However, several strains of 661:integral component of plasma membrane 324: 285: 280: 223: 182: 177: 2123:(Mouse Toll-like receptor 6) at the 2102:(Human Toll-like receptor 6) at the 1606: 1604: 1602: 1600: 802:toll-like receptor signaling pathway 630:protein heterodimerization activity 13: 2010: 1780:Scandinavian Journal of Immunology 1764: 691:intracellular anatomical structure 14: 4421: 2048: 1597: 1395:mitogen‐activated protein kinases 1237:that in humans is encoded by the 867:cellular response to amyloid-beta 792:response to bacterial lipoprotein 2032:10.1097/00003246-200201001-00001 546: 308: 301: 295: 272: 207: 200: 194: 169: 1957: 1916: 1323: 777:T-helper 1 type immune response 1878:Journal of Immunology Research 1723: 1544: 1526: 1463:single-nucleotide polymorphism 1360:virus and glycoprotein B from 787:nitric oxide metabolic process 646:integral component of membrane 557:More reference expression data 526:More reference expression data 1: 1583:10.1016/S0378-1119(99)00098-0 1477: 1408: 1379: 1248:family, which belongs to the 742:defense response to bacterium 293: 192: 103:, CD286, toll like receptor 6 1749:10.1016/j.immuni.2009.09.018 1348:, found on the cell wall of 1250:pattern recognition receptor 590:Toll-like receptor 2 binding 7: 4405:Clusters of differentiation 4400:Genes on human chromosome 4 2166:clusters of differentiation 2069:human gene location in the 1942:10.4049/jimmunol.173.6.3916 1339: 1279: 651:phagocytic vesicle membrane 620:signaling receptor activity 10: 4426: 2081:human gene details in the 1469:. Increased occurrence of 1274:cluster of differentiation 797:microglial cell activation 615:signaling receptor binding 4314: 4288: 4210: 3969: 3763: 3512: 3196: 2919: 2579: 2177: 1552:"Mouse PubMed Reference:" 1534:"Human PubMed Reference:" 1217: 1212: 1208: 1201: 1185: 1166: 1143: 1139: 1122: 1118: 1111: 1088: 1084: 1063: 1059: 1052: 1039: 1035: 1020: 1016: 1007: 994: 990: 975: 971: 962: 949: 945: 930: 926: 917: 902: 895: 891: 875: 625:identical protein binding 575: 571: 554: 545: 536: 523: 472: 463: 410: 401: 371: 363: 359: 342: 329: 292: 271: 262: 258: 241: 228: 191: 168: 159: 155: 110: 107: 97: 90: 85: 66: 61: 44: 39: 34: 30: 26: 21: 2059:Medical Subject Headings 1699:10.4049/jimmunol.1002122 1649:10.3389/fimmu.2012.00079 1636:Frontiers in Immunology 1179:Chr 5: 65.11 – 65.12 Mb 1172:Chr 4: 38.82 – 38.86 Mb 16:Protein found in humans 2020:Critical Care Medicine 1350:gram-positive bacteria 1302:gram-positive bacteria 1258:gram-positive bacteria 772:innate immune response 326:5 C3.1|5 33.54 cM 4316:Downstream signalling 1929:Journal of Immunology 1687:Journal of Immunology 1467:Legionnaires’ Disease 1457:Clinical significance 752:inflammatory response 717:immune system process 488:stroma of bone marrow 2055:Toll-Like+Receptor+6 1982:10.1038/gene.2013.34 1891:10.1155/2016/4368101 1399:lactic acid bacteria 1298:toll-like receptor 2 1254:toll-like receptor 2 1231:Toll-like receptor 6 610:amyloid-beta binding 287:Chromosome 5 (mouse) 185:Chromosome 4 (human) 62:List of PDB id codes 35:Available structures 4410:Toll-like receptors 2083:UCSC Genome Browser 2071:UCSC Genome Browser 1833:2016NatSR...634561R 767:signal transduction 666:cytoplasmic vesicle 605:lipopeptide binding 2026:(1 Suppl): S1-11. 1970:Genes and Immunity 1821:Scientific Reports 1286:toll-like receptor 1246:toll-like receptor 997:ENSMUSG00000051498 705:Biological process 639:Cellular component 583:Molecular function 512:tibiofemoral joint 4387: 4386: 4205:signaling pathway 4199:Signaling pathway 4165: 4164: 1841:10.1038/srep34561 1793:10.1111/sji.12771 1391:nuclear factor-κB 1346:lipoteichoic acid 1228: 1227: 1224: 1223: 1197: 1196: 1162: 1161: 1133: 1132: 1107: 1106: 1078: 1077: 1048: 1047: 1029: 1028: 1003: 1002: 984: 983: 958: 957: 939: 938: 887: 886: 567: 566: 563: 562: 532: 531: 519: 518: 457: 456: 438:bone marrow cells 355: 354: 254: 253: 81: 80: 77: 76: 45:Ortholog search: 4417: 4192: 4185: 4178: 4169: 4168: 2155: 2148: 2141: 2132: 2131: 2043: 2004: 2003: 1993: 1961: 1955: 1954: 1944: 1920: 1914: 1913: 1903: 1893: 1869: 1863: 1862: 1852: 1812: 1806: 1805: 1795: 1771: 1762: 1761: 1751: 1727: 1721: 1720: 1710: 1678: 1672: 1671: 1661: 1651: 1627: 1616: 1615: 1608: 1595: 1594: 1566: 1560: 1559: 1548: 1542: 1541: 1530: 1524: 1514: 1503: 1493: 1210: 1209: 1181: 1174: 1157: 1137: 1136: 1128: 1116: 1115: 1112:RefSeq (protein) 1102: 1082: 1081: 1073: 1057: 1056: 1033: 1032: 1014: 1013: 988: 987: 969: 968: 943: 942: 924: 923: 893: 892: 696:receptor complex 573: 572: 559: 550: 543: 542: 528: 468: 466:Top expressed in 461: 460: 406: 404:Top expressed in 399: 398: 378: 377: 361: 360: 351: 338: 327: 312: 305: 299: 288: 276: 260: 259: 250: 237: 226: 211: 204: 198: 187: 173: 157: 156: 151: 149:TLR6 - orthologs 102: 95: 72: 59: 58: 53: 32: 31: 19: 18: 4425: 4424: 4420: 4419: 4418: 4416: 4415: 4414: 4390: 4389: 4388: 4383: 4310: 4289:Other receptors 4284: 4206: 4196: 4166: 4161: 3965: 3759: 3508: 3192: 2915: 2575: 2173: 2159: 2051: 2046: 2013: 2011:Further reading 2008: 2007: 1962: 1958: 1921: 1917: 1870: 1866: 1813: 1809: 1772: 1765: 1728: 1724: 1693:(10): 5916–26. 1679: 1675: 1628: 1619: 1610: 1609: 1598: 1567: 1563: 1550: 1549: 1545: 1532: 1531: 1527: 1515: 1506: 1494: 1485: 1480: 1459: 1427:dendritic cells 1411: 1382: 1375: 1371: 1362:cytomegalovirus 1342: 1326: 1282: 1219:View/Edit Mouse 1214:View/Edit Human 1177: 1170: 1167:Location (UCSC) 1153: 1149: 1145: 1124: 1098: 1094: 1090: 1069: 1065: 978:ENSG00000174130 871: 812:immune response 807:cell activation 700: 686:plasma membrane 671:Golgi apparatus 634: 595:protein binding 555: 524: 515: 510: 506: 502: 498: 496:muscle of thigh 494: 490: 486: 482: 478: 464: 453: 448: 444: 442:Achilles tendon 440: 436: 432: 428: 424: 420: 416: 402: 346: 333: 325: 315: 314: 313: 306: 286: 263:Gene location ( 245: 232: 224: 214: 213: 212: 205: 183: 160:Gene location ( 111: 98: 91: 68: 46: 17: 12: 11: 5: 4423: 4413: 4412: 4407: 4402: 4385: 4384: 4382: 4381: 4376: 4371: 4366: 4361: 4356: 4351: 4346: 4341: 4336: 4331: 4326: 4320: 4318: 4312: 4311: 4309: 4308: 4303: 4298: 4292: 4290: 4286: 4285: 4283: 4282: 4277: 4272: 4267: 4262: 4257: 4252: 4247: 4242: 4237: 4232: 4227: 4222: 4216: 4214: 4208: 4207: 4195: 4194: 4187: 4180: 4172: 4163: 4162: 4160: 4159: 4154: 4149: 4144: 4139: 4134: 4129: 4124: 4119: 4114: 4109: 4104: 4099: 4094: 4089: 4084: 4079: 4074: 4069: 4064: 4059: 4054: 4049: 4044: 4039: 4034: 4029: 4024: 4019: 4014: 4009: 4004: 3999: 3994: 3989: 3984: 3979: 3973: 3971: 3967: 3966: 3964: 3963: 3958: 3953: 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2343: 2339: 2336: 2334: 2331: 2330: 2329: 2326: 2324: 2321: 2319: 2316: 2314: 2311: 2307: 2304: 2302: 2299: 2297: 2294: 2292: 2289: 2288: 2287: 2284: 2282: 2279: 2277: 2274: 2270: 2267: 2266: 2265: 2262: 2260: 2257: 2255: 2252: 2250: 2247: 2245: 2242: 2238: 2235: 2233: 2230: 2228: 2225: 2224: 2223: 2220: 2218: 2215: 2211: 2208: 2206: 2203: 2201: 2198: 2196: 2193: 2191: 2188: 2187: 2186: 2183: 2182: 2180: 2176: 2171: 2167: 2163: 2156: 2151: 2149: 2144: 2142: 2137: 2136: 2133: 2126: 2122: 2121: 2116: 2112: 2108: 2105: 2101: 2100: 2095: 2091: 2087: 2084: 2080: 2079: 2075: 2072: 2068: 2067: 2063: 2060: 2056: 2053: 2052: 2041: 2037: 2033: 2029: 2025: 2021: 2016: 2015: 2001: 1997: 1992: 1987: 1983: 1979: 1975: 1971: 1967: 1960: 1952: 1948: 1943: 1938: 1934: 1930: 1926: 1919: 1911: 1907: 1902: 1897: 1892: 1887: 1883: 1879: 1875: 1868: 1860: 1856: 1851: 1846: 1842: 1838: 1834: 1830: 1826: 1822: 1818: 1811: 1803: 1799: 1794: 1789: 1786:(1): e12771. 1785: 1781: 1777: 1770: 1768: 1759: 1755: 1750: 1745: 1742:(6): 873–84. 1741: 1737: 1733: 1726: 1718: 1714: 1709: 1704: 1700: 1696: 1692: 1688: 1684: 1677: 1669: 1665: 1660: 1655: 1650: 1645: 1641: 1637: 1633: 1626: 1624: 1622: 1613: 1607: 1605: 1603: 1601: 1592: 1588: 1584: 1580: 1576: 1572: 1565: 1557: 1553: 1547: 1539: 1535: 1529: 1522: 1518: 1513: 1511: 1509: 1501: 1497: 1492: 1490: 1488: 1483: 1475: 1472: 1468: 1464: 1454: 1452: 1451:B lymphocytes 1448: 1444: 1440: 1436: 1432: 1428: 1424: 1420: 1416: 1406: 1404: 1400: 1396: 1392: 1388: 1377: 1367: 1363: 1359: 1355: 1351: 1347: 1337: 1335: 1331: 1321: 1319: 1315: 1311: 1307: 1303: 1299: 1295: 1291: 1287: 1277: 1275: 1271: 1267: 1263: 1259: 1255: 1251: 1247: 1243: 1240: 1236: 1232: 1220: 1215: 1211: 1207: 1204: 1200: 1193: 1191: 1188: 1184: 1180: 1176: 1173: 1169: 1165: 1158: 1156: 1152: 1148: 1142: 1138: 1135: 1129: 1127: 1121: 1117: 1114: 1110: 1103: 1101: 1097: 1093: 1087: 1083: 1080: 1074: 1072: 1068: 1062: 1058: 1055: 1053:RefSeq (mRNA) 1051: 1044: 1043: 1038: 1034: 1031: 1025: 1024: 1019: 1015: 1012: 1010: 1006: 999: 998: 993: 989: 986: 980: 979: 974: 970: 967: 965: 961: 954: 953: 948: 944: 941: 935: 934: 929: 925: 922: 920: 916: 913: 910: 908: 905: 901: 898: 894: 890: 883: 879: 874: 868: 865: 863: 860: 858: 855: 853: 850: 848: 845: 843: 840: 838: 835: 833: 830: 828: 825: 823: 820: 818: 815: 813: 810: 808: 805: 803: 800: 798: 795: 793: 790: 788: 785: 783: 780: 778: 775: 773: 770: 768: 765: 763: 760: 758: 755: 753: 750: 748: 745: 743: 740: 738: 735: 733: 730: 728: 725: 723: 720: 718: 715: 713: 710: 709: 707: 704: 703: 697: 694: 692: 689: 687: 684: 682: 679: 677: 676:membrane raft 674: 672: 669: 667: 664: 662: 659: 657: 654: 652: 649: 647: 644: 643: 641: 638: 637: 631: 628: 626: 623: 621: 618: 616: 613: 611: 608: 606: 603: 601: 598: 596: 593: 591: 588: 587: 585: 582: 581: 578: 577:Gene ontology 574: 570: 558: 553: 549: 544: 541: 539: 535: 527: 522: 511: 507: 503: 499: 495: 491: 487: 483: 479: 475: 474: 471: 467: 462: 459: 449: 445: 441: 437: 433: 429: 425: 421: 417: 413: 412: 409: 405: 400: 397: 396: 393: 391: 387: 385: 384: 380: 379: 376: 374: 370: 366: 362: 358: 350: 345: 341: 337: 332: 322: 318: 311: 304: 298: 291: 283: 279: 275: 270: 266: 261: 257: 249: 244: 240: 236: 231: 221: 217: 210: 203: 197: 190: 186: 180: 176: 172: 167: 163: 158: 154: 150: 146: 142: 138: 134: 130: 126: 122: 118: 114: 106: 101: 94: 89: 84: 73: 71: 65: 60: 57: 56: 52: 49: 42: 38: 33: 29: 25: 20: 4244: 3683: 3603: 3581: 3559: 3406: 3369: 3332: 3285: 3255: 3228: 3050: 2956: 2804: 2533: 2285: 2118: 2097: 2077: 2065: 2023: 2019: 1976:(7): 420–6. 1973: 1969: 1959: 1932: 1928: 1918: 1881: 1877: 1867: 1824: 1820: 1810: 1783: 1779: 1739: 1735: 1725: 1690: 1686: 1676: 1639: 1635: 1574: 1570: 1564: 1555: 1546: 1537: 1528: 1461:A 359T>C 1460: 1412: 1383: 1343: 1327: 1324:Interactions 1283: 1269: 1238: 1230: 1229: 1155:NP_001371100 1151:NP_001346109 1144: 1123: 1100:NM_001384171 1096:NM_001359180 1089: 1071:NM_001394553 1064: 1040: 1021: 995: 976: 950: 931: 911: 906: 508:carotid body 388: 381: 108:External IDs 67: 1884:: 4368101. 1443:neutrophils 1435:macrophages 1358:hepatitis C 476:granulocyte 450:gallbladder 426:granulocyte 347:65,117,440 334:65,109,374 246:38,856,817 233:38,822,897 86:Identifiers 4394:Categories 2168:(see also 1523:, May 2017 1502:, May 2017 1478:References 1423:lymph node 1409:Expression 1380:Signalling 1354:mycoplasma 1306:mycoplasma 1290:Drosophila 1262:mycoplasma 422:lymph node 392:(ortholog) 129:HomoloGene 1827:: 34561. 1439:microglia 1431:monocytes 1316:and even 1147:NP_035734 1126:NP_006059 1092:NM_011604 1067:NM_006068 897:Orthologs 137:GeneCards 2162:Proteins 2040:11782555 2000:23823019 1951:15356140 1910:28116318 1859:27708357 1802:31054156 1758:19931471 1736:Immunity 1717:21482737 1668:22566960 1591:10231569 1519:– 1498:– 1447:NK cells 1415:appendix 1340:Agonists 1318:protozoa 1280:Function 1203:Wikidata 876:Sources: 656:membrane 504:calvaria 434:appendix 414:monocyte 3970:301–350 3764:251–300 3716:CD240CE 3513:201–250 3197:151–200 2920:101–150 2125:PDBe-KB 2115:UniProt 2104:PDBe-KB 2094:UniProt 1991:3791179 1901:5223024 1850:5052581 1829:Bibcode 1708:3654378 1659:3342043 1521:Ensembl 1500:Ensembl 1366:zymosan 1314:viruses 1312:, some 1235:protein 1009:UniProt 964:Ensembl 903:Species 882:QuickGO 367:pattern 125:1341296 93:Aliases 4374:TOLLIP 4364:TICAM1 4349:MAP3K7 3977:CD300A 3936:CDw293 3721:CD240D 3582:CD213a 3560:CDw210 3525:CD202b 3499:CDw199 3494:CDw198 3148:CD140b 2580:51–100 2120:Q9EPW9 2099:Q9Y2C9 2061:(MeSH) 2038:  1998:  1988:  1949:  1908:  1898:  1857:  1847:  1800:  1756:  1715:  1705:  1666:  1656:  1642:: 79. 1589:  1471:asthma 1419:spleen 1276:286). 1189:search 1187:PubMed 1042:Q9EPW9 1023:Q9Y2C9 919:Entrez 538:BioGPS 500:thymus 492:spleen 480:embryo 446:tonsil 430:spleen 117:605403 4379:TRAF6 4369:TIRAP 4354:MYD88 4339:IRAK4 4334:IRAK3 4329:IRAK2 4324:IRAK1 4280:TLR13 4275:TLR12 4270:TLR11 4265:TLR10 4157:CD350 4152:CD349 4147:CD344 4142:CD340 4137:CD339 4132:CD338 4127:CD337 4122:CD336 4117:CD335 4112:CD334 4107:CD333 4102:CD332 4097:CD331 4092:CD329 4087:CD328 4082:CD327 4077:CD326 4072:CD325 4067:CD324 4062:CD322 4057:CD321 4052:CD320 4047:CD318 4042:CD317 4037:CD316 4032:CD315 4027:CD314 4022:CD312 4017:CD309 4012:CD307 4007:CD306 4002:CD305 3997:CD304 3992:CD303 3987:CD302 3982:CD301 3961:CD299 3956:CD298 3951:CD297 3946:CD295 3941:CD294 3931:CD292 3926:CD290 3921:CD289 3916:CD288 3911:CD286 3906:CD284 3901:CD283 3896:CD282 3891:CD281 3886:CD280 3881:CD279 3876:CD278 3871:CD276 3866:CD275 3861:CD274 3856:CD273 3851:CD272 3846:CD271 3841:CD269 3836:CD268 3831:CD267 3826:CD266 3821:CD265 3816:CD264 3811:CD263 3806:CD262 3801:CD261 3796:CD258 3791:CD257 3786:CD256 3781:CD254 3776:CD253 3771:CD252 3755:CD249 3750:CD248 3746:CD247 3741:CD246 3736:CD244 3731:CD243 3726:CD241 3711:CD239 3706:CD238 3701:CD236 3684:CD235 3679:CD234 3674:CD233 3669:CD230 3664:CD229 3659:CD228 3654:CD227 3649:CD226 3644:CD225 3639:CD224 3634:CD223 3629:CD222 3624:CD221 3619:CD220 3604:CD218 3599:CD217 3577:CD212 3555:CD209 3550:CD208 3545:CD207 3540:CD206 3535:CD205 3530:CD204 3520:CD201 3504:CD200 3489:CD197 3484:CD196 3479:CD195 3474:CD194 3469:CD193 3464:CD192 3459:CD191 3454:CD186 3449:CD185 3444:CD184 3439:CD183 3434:CD182 3429:CD181 3424:CD180 3407:CD179 3402:CD178 3397:CD177 3392:CD174 3370:CD172 3365:CD171 3360:CD170 3355:CD169 3350:CD168 3333:CD167 3328:CD166 3323:CD164 3318:CD163 3313:CD162 3308:CD161 3303:CD160 3286:CD159 3256:CD158 3251:CD157 3229:CD156 3224:CD155 3219:CD154 3214:CD153 3209:CD152 3204:CD151 3188:CD150 3183:CD148 3178:CD147 3173:CD146 3168:CD144 3163:CD143 3158:CD142 3153:CD141 3143:CD138 3138:CD137 3133:CD136 3128:CD135 3123:CD134 3118:CD133 3113:CD132 3108:CD131 3103:CD130 3098:CD129 3093:CD127 3088:CD126 3083:CD125 3078:CD124 3073:CD123 3068:CD122 3051:CD121 3034:CD120 3029:CD119 3024:CD118 3019:CD117 3014:CD116 3009:CD115 3004:CD114 2999:CD113 2994:CD112 2989:CD111 2984:CD110 2979:CD109 2974:CD108 2957:CD107 2952:CD106 2947:CD105 2942:CD104 2937:CD103 2932:CD102 2927:CD101 2911:CD100 1387:MyD88 1310:fungi 1270:CD286 1266:NF-κB 1233:is a 952:21899 933:10333 912:Mouse 907:Human 878:Amigo 484:blood 418:blood 390:Mouse 383:Human 330:Start 265:Mouse 229:Start 162:Human 133:21223 4359:TAB1 4344:IRF3 4296:CD14 4260:TLR9 4255:TLR8 4250:TLR7 4245:TLR6 4240:TLR5 4235:TLR4 4230:TLR3 4225:TLR2 4220:TLR1 4212:TLRs 2906:CD99 2901:CD98 2896:CD97 2891:CD96 2886:CD95 2881:CD94 2876:CD93 2871:CD92 2867:CD91 2862:CD90 2857:CD89 2852:CD88 2847:CD87 2842:CD86 2805:CD85 2800:CD84 2795:CD83 2790:CD82 2785:CD81 2780:CD80 2763:CD79 2758:CD78 2753:CD74 2748:CD73 2743:CD72 2738:CD71 2733:CD70 2728:CD69 2723:CD68 2686:CD66 2664:CD64 2659:CD63 2637:CD62 2632:CD61 2627:CD59 2622:CD58 2617:CD57 2612:CD56 2607:CD55 2602:CD54 2597:CD53 2592:CD52 2587:CD51 2571:CD50 2534:CD49 2529:CD48 2524:CD47 2519:CD46 2514:CD45 2509:CD44 2504:CD43 2477:CD42 2472:CD41 2467:CD40 2462:CD39 2457:CD38 2452:CD37 2447:CD36 2442:CD35 2437:CD34 2432:CD33 2415:CD32 2410:CD31 2405:CD30 2400:CD29 2395:CD28 2390:CD27 2385:CD26 2380:CD25 2375:CD24 2370:CD23 2365:CD22 2360:CD21 2355:CD20 2350:CD19 2345:CD18 2328:CD16 2323:CD15 2318:CD14 2313:CD13 2286:CD11 2281:CD10 2178:1–50 2113:for 2092:for 2078:TLR6 2066:TLR6 2036:PMID 1996:PMID 1947:PMID 1906:PMID 1882:2016 1855:PMID 1798:PMID 1754:PMID 1713:PMID 1664:PMID 1587:PMID 1571:Gene 1449:and 1421:and 1334:TLR9 1330:TLR2 1260:and 1242:gene 1239:TLR6 373:Bgee 321:Band 282:Chr. 225:4p14 220:Band 179:Chr. 141:TLR6 113:OMIM 100:TLR6 70:4OM7 51:RCSB 48:PDBe 22:TLR6 4306:MD2 4301:LBP 4203:TLR 2276:CD9 2264:CD8 2259:CD7 2254:CD6 2249:CD5 2244:CD4 2222:CD3 2217:CD2 2190:a-c 2185:CD1 2111:PDB 2090:PDB 2028:doi 1986:PMC 1978:doi 1937:doi 1933:173 1896:PMC 1886:doi 1845:PMC 1837:doi 1788:doi 1744:doi 1703:PMC 1695:doi 1691:186 1654:PMC 1644:doi 1579:doi 1575:231 1372:CSK 343:End 242:End 145:OMA 121:MGI 41:PDB 4396:: 4201:: 3748:- 2869:- 2210:1E 2205:1D 2200:1B 2195:1A 2164:: 2117:: 2096:: 2034:. 2024:30 2022:. 1994:. 1984:. 1974:14 1972:. 1968:. 1945:. 1931:. 1927:. 1904:. 1894:. 1880:. 1876:. 1853:. 1843:. 1835:. 1823:. 1819:. 1796:. 1784:90 1782:. 1778:. 1766:^ 1752:. 1740:31 1738:. 1734:. 1711:. 1701:. 1689:. 1685:. 1662:. 1652:. 1638:. 1634:. 1620:^ 1599:^ 1585:. 1573:. 1554:. 1536:. 1507:^ 1486:^ 1453:. 1445:, 1441:, 1437:, 1433:, 1429:, 1417:, 1320:. 1308:, 1304:, 880:/ 349:bp 336:bp 248:bp 235:bp 143:; 139:: 135:; 131:: 127:; 123:: 119:; 115:: 4191:e 4184:t 4177:v 3694:b 3689:a 3615:) 3613:b 3608:a 3606:( 3592:2 3587:1 3570:b 3565:a 3417:b 3412:a 3385:g 3380:b 3375:a 3343:b 3338:a 3296:c 3291:a 3282:) 3280:k 3275:i 3270:e 3265:d 3260:a 3258:( 3244:c 3239:b 3234:a 3061:b 3056:a 3044:b 3039:a 2967:b 2962:a 2835:k 2830:j 2825:h 2820:e 2815:d 2810:a 2773:b 2768:a 2716:f 2711:e 2706:d 2701:c 2696:b 2691:a 2679:C 2674:B 2669:A 2652:P 2647:L 2642:E 2564:f 2559:e 2554:d 2549:c 2544:b 2539:a 2497:d 2492:c 2487:b 2482:a 2425:B 2420:A 2338:B 2333:A 2306:d 2301:c 2296:b 2291:a 2269:a 2237:ε 2232:δ 2227:γ 2172:) 2154:e 2147:t 2140:v 2127:. 2106:. 2085:. 2073:. 2042:. 2030:: 2002:. 1980:: 1953:. 1939:: 1912:. 1888:: 1861:. 1839:: 1831:: 1825:6 1804:. 1790:: 1760:. 1746:: 1719:. 1697:: 1670:. 1646:: 1640:3 1614:. 1593:. 1581:: 1558:. 1540:. 1374:4 1370:2 1272:( 267:) 164:) 147::

Index

PDB
PDBe
RCSB
4OM7
Aliases
TLR6
OMIM
605403
MGI
1341296
HomoloGene
21223
GeneCards
TLR6
OMA
TLR6 - orthologs
Human
Chromosome 4 (human)
Chr.
Chromosome 4 (human)
Chromosome 4 (human)
Genomic location for TLR6
Genomic location for TLR6
Band
bp
bp
Mouse
Chromosome 5 (mouse)
Chr.
Chromosome 5 (mouse)

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