376:
353:
275:
250:
627:
382:
281:
1310:
transcription factor NF-ÎșB and an antiviral response that leads to proinflammatory cytokine synthesis. TLR8 recognizes single-stranded RNA of viruses such as HIV and HCV. TLR8 is also involved in the activation of dendritic cells to produce inflammatory factors to help regulate tumor growth, so TLR8 is often used as a target in the research for therapies in treating cancers including ovarian cancer and lymphomas.
1309:
TLR8 is an endosomal receptor that recognizes single stranded RNA (ssRNA), and can recognize ssRNA viruses such as
Influenza, Sendai, and Coxsackie B viruses. TLR8 binding to the viral RNA recruits the myeloid differentiation primary response protein 88 (MyD88) and leads to activation of the
61:
1306:. TLR8 is activated by ssRNA and forms a dimer complex when uridine released from the degraded ssRNA binds at one active site in between the dimers and a short oligonucleotide binds to another active site on the surface of the TLR8 structure.
1857:
Davila S, Hibberd ML, Hari Dass R, Wong HE, Sahiratmadja E, Bonnard C, Alisjahbana B, Szeszko JS, Balabanova Y, Drobniewski F, van Crevel R, van de Vosse E, Nejentsev S, Ottenhoff TH, Seielstad M (October 2008).
389:
288:
1302:
TLR8 can recognize GU-rich single-stranded RNA. However, the presence of GU-rich sequences in the single-stranded RNA is not sufficient to stimulate TLR8. TLR8 recognizes G-rich
1291:
necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood
1566:
Seizer L, Rahimi S, Santos-Sierra S, Drexel M (2022) Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons. PLoS ONE 17(5): e0267860.
1699:
Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, Wang DY, Li Y, Wang HY, Wang RF (August 2005). "Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function".
2951:
1909:
1750:
Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, et al. (February 2015). "Toll-like receptor 8 senses degradation products of single-stranded RNA".
1262:
TLR8 seems to function differently in humans and mice. Until recently, TLR8 was believed to be nonfunctional in mice, but it seems to counteract TLR7 activity
2090:
945:
926:
211:
4127:
2941:
1420:
2068:
1402:
1518:
Sarvestani ST, Williams BR, Gantier MP (August 2012). "Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing".
1469:
Demaria O, Pagni PP, Traub S, de
Gassart A, Branzk N, Murphy AJ, Valenzuela DM, Yancopoulos GD, Flavell RA, Alexopoulou L (October 2010).
2921:
1176:
3783:
2107:
2083:
1169:
1553:
3514:
1299:, on chromosome X. Recent research has also shown the expression of TLR8 in hippocampal interneurons, with yet unknown function.
3502:
3280:
1280:
3566:
3561:
3507:
3287:
1642:
Zhang Y, El-Far M, Dupuy FP, Abdel-Hakeem MS, He Z, Procopio FA, Shi Y, Haddad EK, Ancuta P, Sekaly RP, Said EA (July 2016).
1385:
4347:
4337:
3020:
2946:
2076:
1814:
Huang X, Zhang X, Lu M (August 2021). "Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics".
58:
1644:"HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses"
4120:
4049:
4044:
4039:
4034:
2961:
1364:
4253:
4238:
4014:
375:
3250:
3818:
3312:
2998:
1439:
1389:
1368:
352:
2065:
provides an overview of all the structure information available in the PDB for Human Toll-like receptor 8 (TLR8)
4113:
3457:
2993:
1927:
Hu Z, Tanji H, Jiang S, Zhang S, Koo K, Chan J, Sakaniwa K, Ohto U, Candia A, Shimizu T, Yin H (October 2018).
990:
2098:
1860:"Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis"
1582:
Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S (March 2004).
3954:
3426:
3421:
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971:
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191:
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1123:
1119:
1085:
1064:
1060:
3035:
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3025:
3015:
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2250:
1319:
1335:) have undergone clinical trials as immune stimulants in combination therapy for some cancers.
4243:
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4197:
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4182:
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3329:
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263:
17:
219:
8:
4136:
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1953:
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1495:
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223:
2028:
2011:
1440:"Three novel mammalian toll-like receptors: gene structure, expression, and evolution"
860:
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1998:
1994:
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1613:
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1500:
1451:
1284:
171:
51:
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1736:
1584:"Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8"
203:
3823:
3556:
3477:
3040:
2233:
2159:
2023:
1990:
1948:
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1940:
1881:
1871:
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1671:
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1625:
1603:
1527:
1490:
1482:
468:
399:
343:
298:
1910:"Immune Stimulant No Help When Added to Chemotherapy for Recurrent Ovarian Cancer"
1827:
1265:
The TLR family plays a fundamental role in pathogen recognition and activation of
3883:
2419:
2414:
2337:
1876:
1303:
1266:
443:
227:
1425:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1407:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3668:
3090:
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2404:
1567:
544:
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2186:
655:
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2002:
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1455:
626:
461:
240:
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1216:
1211:
4004:
3653:
3431:
3406:
3105:
2727:
2653:
2127:
1035:
1016:
1794:"TLR7 and TLR8: Key players in the antiviral response - Innate immunity"
3934:
3658:
3339:
3080:
2956:
2589:
2584:
2579:
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2218:
1318:
Genetic variants in TLR8 has recently been linked to susceptibility to
1271:
360:
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1763:
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1929:"Small-Molecule TLR8 Antagonists via Structure-Based Rational Design"
1486:
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326:
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3202:
3197:
3115:
2808:
2648:
2643:
2638:
2633:
2628:
2099:
1342:) may have therapeutic applications against autoimmune disorders.
1279:
and share structural and functional similarities. They recognize
1232:
1002:
957:
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871:
635:
195:
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4286:
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2238:
2228:
2016:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
4135:
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3999:
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3472:
3467:
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3188:
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2804:
2799:
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2779:
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2722:
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2260:
2255:
2206:
2174:
2169:
2164:
2147:
2142:
2137:
2132:
1468:
1296:
1239:
1981:
Lien E, Ingalls RR (January 2002). "Toll-like receptors".
1856:
3601:
2213:
2201:
2196:
2191:
2181:
2154:
2122:
1517:
1295:, and lies in close proximity to another family member,
451:
1749:
1438:
Du X, Poltorak A, Wei Y, Beutler B (September 2000).
616:
1437:
791:
MyD88-dependent toll-like receptor signaling pathway
1381:
1379:
1377:
1360:
1358:
1356:
1926:
398:
297:
4329:
1698:
1637:
1635:
1577:
1575:
1471:"TLR8 deficiency leads to autoimmunity in mice"
1374:
1353:
861:positive regulation of interleukin-6 production
1386:GRCm38: Ensembl release 89: ENSMUSG00000040522
4121:
2084:
1809:
1807:
1786:
1520:Journal of Interferon & Cytokine Research
816:positive regulation of innate immune response
1920:
1813:
1692:
1632:
1572:
1568:https://doi.org/10.1371/journal.pone.0267860
2012:"Toll-like receptors as adjuvant receptors"
2009:
1980:
1511:
1462:
1431:
1365:GRCh38: Ensembl release 89: ENSG00000101916
4128:
4114:
2091:
2077:
1804:
2108:list of human clusters of differentiation
2055:at the U.S. National Library of Medicine
2027:
1952:
1885:
1875:
1752:Nature Structural & Molecular Biology
1675:
1607:
1494:
694:transmembrane signaling receptor activity
1554:"Entrez Gene: TLR8 toll-like receptor 8"
1313:
801:cellular response to mechanical stimulus
811:immunoglobulin mediated immune response
14:
4330:
1281:pathogen-associated molecular patterns
851:toll-like receptor 8 signaling pathway
821:toll-like receptor 9 signaling pathway
4109:
2072:
1850:
1475:The Journal of Clinical Investigation
776:regulation of protein phosphorylation
745:integral component of plasma membrane
704:pattern recognition receptor activity
403:
364:
359:
302:
261:
256:
182:, CD288, toll like receptor 8, hIMD98
846:toll-like receptor signaling pathway
2010:Kaisho T, Akira S (February 2002).
1325:
1242:. TLR8 has also been designated as
826:I-kappaB kinase/NF-kappaB signaling
24:
1973:
25:
4359:
2046:
1269:. TLRs are highly conserved from
1235:that in humans is encoded by the
1995:10.1097/00003246-200201001-00001
1816:Expert Opinion on Drug Discovery
1287:, and mediate the production of
750:external side of plasma membrane
625:
387:
380:
374:
351:
286:
279:
273:
248:
1902:
1743:
1945:10.1016/j.chembiol.2018.07.004
1560:
1546:
1413:
1395:
1283:(PAMPs) that are expressed on
755:integral component of membrane
720:endoplasmic reticulum membrane
636:More reference expression data
605:More reference expression data
13:
1:
2029:10.1016/S0167-4889(01)00182-3
1828:10.1080/17460441.2021.1898369
1346:
372:
271:
1877:10.1371/journal.pgen.1000218
1250:288). It is a member of the
7:
4348:Clusters of differentiation
4338:Genes on human chromosome X
2104:clusters of differentiation
1257:
699:signaling receptor activity
689:single-stranded RNA binding
684:double-stranded RNA binding
10:
4364:
1248:cluster of differentiation
796:microglial cell activation
4252:
4226:
4148:
3907:
3701:
3450:
3134:
2857:
2517:
2115:
1444:European Cytokine Network
1421:"Mouse PubMed Reference:"
1403:"Human PubMed Reference:"
1215:
1210:
1206:
1199:
1183:
1177:Chr X: 166.03 â 166.05 Mb
1164:
1141:
1137:
1116:
1112:
1105:
1082:
1078:
1057:
1053:
1046:
1033:
1029:
1014:
1010:
1001:
988:
984:
969:
965:
956:
943:
939:
924:
920:
911:
896:
889:
885:
869:
806:defense response to virus
674:identical protein binding
654:
650:
633:
624:
615:
602:
551:
542:
489:
480:
450:
442:
438:
421:
408:
371:
350:
341:
337:
320:
307:
270:
247:
238:
234:
189:
186:
176:
169:
164:
77:
72:
55:
50:
45:
41:
37:
32:
2057:Medical Subject Headings
1721:10.1126/science.1113401
1609:10.1126/science.1093620
1338:TLR8 antagonists (e.g.
1170:Chr X: 12.91 â 12.92 Mb
27:Protein found in humans
1983:Critical Care Medicine
1320:pulmonary tuberculosis
836:innate immune response
4254:Downstream signalling
1933:Cell Chemical Biology
1532:10.1089/jir.2012.0014
1314:Clinical significance
841:inflammatory response
781:immune system process
735:endolysosome membrane
567:stroma of bone marrow
2053:Toll-Like+Receptor+8
1939:(10): 1286â1291.e3.
1331:TLR8 agonists (e.g.
1229:Toll-like receptor 8
366:X chromosome (mouse)
264:X chromosome (human)
73:List of PDB id codes
46:Available structures
4343:Toll-like receptors
1713:2005Sci...309.1380P
1660:2016NatSR...629447Z
1600:2004Sci...303.1526H
831:signal transduction
1989:(1 Suppl): S1-11.
1648:Scientific Reports
1252:toll-like receptor
991:ENSMUSG00000040522
769:Biological process
713:Cellular component
662:Molecular function
529:lower lobe of lung
4325:
4324:
4143:signaling pathway
4137:Signaling pathway
4103:
4102:
1914:Targeted Oncology
1764:10.1038/nsmb.2943
1668:10.1038/srep29447
1285:infectious agents
1226:
1225:
1222:
1221:
1195:
1194:
1160:
1159:
1131:
1130:
1101:
1100:
1072:
1071:
1042:
1041:
1023:
1022:
997:
996:
978:
977:
952:
951:
933:
932:
881:
880:
786:response to virus
740:endosome membrane
646:
645:
642:
641:
611:
610:
598:
597:
536:
535:
434:
433:
333:
332:
160:
159:
156:
155:
56:Ortholog search:
16:(Redirected from
4355:
4130:
4123:
4116:
4107:
4106:
2093:
2086:
2079:
2070:
2069:
2041:
2031:
2006:
1967:
1966:
1956:
1924:
1918:
1917:
1906:
1900:
1899:
1889:
1879:
1870:(10): e1000218.
1854:
1848:
1847:
1811:
1802:
1801:
1790:
1784:
1783:
1747:
1741:
1740:
1707:(5739): 1380â4.
1696:
1690:
1689:
1679:
1639:
1630:
1629:
1611:
1594:(5663): 1526â9.
1579:
1570:
1564:
1558:
1557:
1550:
1544:
1543:
1515:
1509:
1508:
1498:
1487:10.1172/JCI42081
1466:
1460:
1459:
1435:
1429:
1428:
1417:
1411:
1410:
1399:
1393:
1383:
1372:
1362:
1326:As a drug target
1304:oligonucleotides
1208:
1207:
1179:
1172:
1155:
1135:
1134:
1126:
1110:
1109:
1106:RefSeq (protein)
1096:
1076:
1075:
1067:
1051:
1050:
1027:
1026:
1008:
1007:
982:
981:
963:
962:
937:
936:
918:
917:
887:
886:
652:
651:
638:
629:
622:
621:
607:
571:secondary oocyte
547:
545:Top expressed in
540:
539:
485:
483:Top expressed in
478:
477:
457:
456:
440:
439:
430:
417:
406:
391:
384:
378:
367:
355:
339:
338:
329:
316:
305:
290:
283:
277:
266:
252:
236:
235:
230:
228:TLR8 - orthologs
181:
174:
151:
70:
69:
64:
43:
42:
30:
29:
21:
4363:
4362:
4358:
4357:
4356:
4354:
4353:
4352:
4328:
4327:
4326:
4321:
4248:
4227:Other receptors
4222:
4144:
4134:
4104:
4099:
3903:
3697:
3446:
3130:
2853:
2513:
2111:
2097:
2049:
2044:
1976:
1974:Further reading
1971:
1970:
1925:
1921:
1908:
1907:
1903:
1855:
1851:
1812:
1805:
1792:
1791:
1787:
1748:
1744:
1697:
1693:
1640:
1633:
1580:
1573:
1565:
1561:
1552:
1551:
1547:
1516:
1512:
1481:(10): 3651â62.
1467:
1463:
1436:
1432:
1419:
1418:
1414:
1401:
1400:
1396:
1384:
1375:
1363:
1354:
1349:
1328:
1316:
1267:innate immunity
1260:
1217:View/Edit Mouse
1212:View/Edit Human
1175:
1168:
1165:Location (UCSC)
1151:
1147:
1143:
1122:
1118:
1092:
1088:
1084:
1063:
1059:
972:ENSG00000101916
865:
856:immune response
764:
760:plasma membrane
708:
634:
603:
594:
589:
585:
583:muscle of thigh
581:
577:
573:
569:
565:
561:
557:
543:
532:
527:
525:parietal pleura
523:
519:
515:
511:
509:trabecular bone
507:
505:visceral pleura
503:
499:
495:
481:
425:
412:
404:
394:
393:
392:
385:
365:
342:Gene location (
324:
311:
303:
293:
292:
291:
284:
262:
239:Gene location (
190:
177:
170:
79:
57:
28:
23:
22:
15:
12:
11:
5:
4361:
4351:
4350:
4345:
4340:
4323:
4322:
4320:
4319:
4314:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4269:
4264:
4258:
4256:
4250:
4249:
4247:
4246:
4241:
4236:
4230:
4228:
4224:
4223:
4221:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4154:
4152:
4146:
4145:
4133:
4132:
4125:
4118:
4110:
4101:
4100:
4098:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4052:
4047:
4042:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
4002:
3997:
3992:
3987:
3982:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3937:
3932:
3927:
3922:
3917:
3911:
3909:
3905:
3904:
3902:
3901:
3896:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3705:
3703:
3699:
3698:
3696:
3695:
3690:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3635:
3634:
3629:
3619:
3614:
3609:
3604:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3548:
3539:
3534:
3533:
3532:
3527:
3517:
3512:
3511:
3510:
3505:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3454:
3452:
3448:
3447:
3445:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3358:
3357:
3352:
3342:
3337:
3332:
3327:
3326:
3325:
3320:
3315:
3305:
3300:
3295:
3290:
3285:
3284:
3283:
3278:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3237:
3236:
3231:
3221:
3215:
3210:
3205:
3200:
3191:
3186:
3185:
3184:
3179:
3174:
3164:
3159:
3154:
3149:
3144:
3138:
3136:
3132:
3131:
3129:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
3002:
3001:
2996:
2986:
2985:
2984:
2979:
2969:
2964:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2919:
2914:
2909:
2908:
2907:
2902:
2892:
2887:
2882:
2877:
2872:
2867:
2861:
2859:
2855:
2854:
2852:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2802:
2797:
2792:
2787:
2782:
2777:
2776:
2775:
2770:
2765:
2760:
2755:
2750:
2740:
2735:
2730:
2725:
2720:
2715:
2714:
2713:
2708:
2698:
2693:
2688:
2683:
2678:
2673:
2668:
2663:
2658:
2657:
2656:
2651:
2646:
2641:
2636:
2631:
2621:
2620:
2619:
2614:
2609:
2599:
2594:
2593:
2592:
2587:
2582:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2521:
2519:
2515:
2514:
2512:
2511:
2506:
2505:
2504:
2499:
2494:
2489:
2484:
2479:
2469:
2464:
2459:
2454:
2449:
2444:
2439:
2438:
2437:
2432:
2427:
2422:
2412:
2407:
2402:
2397:
2392:
2387:
2382:
2377:
2372:
2367:
2366:
2365:
2360:
2350:
2345:
2340:
2335:
2330:
2325:
2320:
2315:
2310:
2305:
2300:
2295:
2290:
2285:
2280:
2279:
2278:
2273:
2263:
2258:
2253:
2248:
2247:
2246:
2241:
2236:
2231:
2221:
2216:
2211:
2210:
2209:
2199:
2194:
2189:
2184:
2179:
2178:
2177:
2172:
2167:
2157:
2152:
2151:
2150:
2145:
2140:
2135:
2130:
2119:
2117:
2113:
2112:
2096:
2095:
2088:
2081:
2073:
2067:
2066:
2060:
2048:
2047:External links
2045:
2043:
2042:
2007:
1977:
1975:
1972:
1969:
1968:
1919:
1901:
1849:
1822:(8): 869â880.
1803:
1785:
1758:(2): 109â115.
1742:
1691:
1631:
1571:
1559:
1545:
1510:
1461:
1430:
1412:
1394:
1373:
1351:
1350:
1348:
1345:
1344:
1343:
1336:
1327:
1324:
1315:
1312:
1259:
1256:
1254:(TLR) family.
1224:
1223:
1220:
1219:
1214:
1204:
1203:
1197:
1196:
1193:
1192:
1190:
1188:
1181:
1180:
1173:
1166:
1162:
1161:
1158:
1157:
1139:
1138:
1132:
1129:
1128:
1114:
1113:
1107:
1103:
1102:
1099:
1098:
1080:
1079:
1073:
1070:
1069:
1055:
1054:
1048:
1044:
1043:
1040:
1039:
1031:
1030:
1024:
1021:
1020:
1012:
1011:
1005:
999:
998:
995:
994:
986:
985:
979:
976:
975:
967:
966:
960:
954:
953:
950:
949:
941:
940:
934:
931:
930:
922:
921:
915:
909:
908:
903:
898:
894:
893:
883:
882:
879:
878:
867:
866:
864:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
772:
770:
766:
765:
763:
762:
757:
752:
747:
742:
737:
732:
730:Golgi membrane
727:
722:
716:
714:
710:
709:
707:
706:
701:
696:
691:
686:
681:
676:
671:
665:
663:
659:
658:
648:
647:
644:
643:
640:
639:
631:
630:
619:
613:
612:
609:
608:
600:
599:
596:
595:
593:
592:
588:
584:
580:
576:
572:
568:
564:
560:
556:
552:
549:
548:
537:
534:
533:
531:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
487:
486:
474:
473:
465:
454:
448:
447:
444:RNA expression
436:
435:
432:
431:
423:
419:
418:
410:
407:
402:
396:
395:
386:
379:
373:
369:
368:
363:
357:
356:
348:
347:
335:
334:
331:
330:
322:
318:
317:
309:
306:
301:
295:
294:
285:
278:
272:
268:
267:
260:
254:
253:
245:
244:
232:
231:
188:
184:
183:
175:
167:
166:
162:
161:
158:
157:
154:
153:
75:
74:
66:
65:
54:
48:
47:
39:
38:
35:
34:
26:
9:
6:
4:
3:
2:
4360:
4349:
4346:
4344:
4341:
4339:
4336:
4335:
4333:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4259:
4257:
4255:
4251:
4245:
4242:
4240:
4237:
4235:
4232:
4231:
4229:
4225:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4155:
4153:
4151:
4147:
4142:
4138:
4131:
4126:
4124:
4119:
4117:
4112:
4111:
4108:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3912:
3910:
3906:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3706:
3704:
3700:
3694:
3691:
3689:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3633:
3630:
3628:
3625:
3624:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3552:
3549:
3547:
3543:
3540:
3538:
3535:
3531:
3528:
3526:
3523:
3522:
3521:
3518:
3516:
3513:
3509:
3506:
3504:
3501:
3500:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3455:
3453:
3449:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3356:
3353:
3351:
3348:
3347:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3324:
3321:
3319:
3316:
3314:
3311:
3310:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3282:
3279:
3277:
3274:
3273:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3235:
3232:
3230:
3227:
3226:
3225:
3222:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3195:
3192:
3190:
3187:
3183:
3180:
3178:
3175:
3173:
3170:
3169:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3139:
3137:
3133:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3000:
2997:
2995:
2992:
2991:
2990:
2987:
2983:
2980:
2978:
2975:
2974:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2906:
2903:
2901:
2898:
2897:
2896:
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2862:
2860:
2856:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2745:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2712:
2709:
2707:
2704:
2703:
2702:
2699:
2697:
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2626:
2625:
2622:
2618:
2615:
2613:
2610:
2608:
2605:
2604:
2603:
2600:
2598:
2595:
2591:
2588:
2586:
2583:
2581:
2578:
2577:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2522:
2520:
2516:
2510:
2507:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2474:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2455:
2453:
2450:
2448:
2445:
2443:
2440:
2436:
2433:
2431:
2428:
2426:
2423:
2421:
2418:
2417:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2383:
2381:
2378:
2376:
2373:
2371:
2368:
2364:
2361:
2359:
2356:
2355:
2354:
2351:
2349:
2346:
2344:
2341:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2277:
2274:
2272:
2269:
2268:
2267:
2264:
2262:
2259:
2257:
2254:
2252:
2249:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2226:
2225:
2222:
2220:
2217:
2215:
2212:
2208:
2205:
2204:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2176:
2173:
2171:
2168:
2166:
2163:
2162:
2161:
2158:
2156:
2153:
2149:
2146:
2144:
2141:
2139:
2136:
2134:
2131:
2129:
2126:
2125:
2124:
2121:
2120:
2118:
2114:
2109:
2105:
2101:
2094:
2089:
2087:
2082:
2080:
2075:
2074:
2071:
2064:
2061:
2058:
2054:
2051:
2050:
2039:
2035:
2030:
2025:
2021:
2017:
2013:
2008:
2004:
2000:
1996:
1992:
1988:
1984:
1979:
1978:
1964:
1960:
1955:
1950:
1946:
1942:
1938:
1934:
1930:
1923:
1916:. March 2017.
1915:
1911:
1905:
1897:
1893:
1888:
1883:
1878:
1873:
1869:
1865:
1864:PLOS Genetics
1861:
1853:
1845:
1841:
1837:
1833:
1829:
1825:
1821:
1817:
1810:
1808:
1799:
1795:
1789:
1781:
1777:
1773:
1769:
1765:
1761:
1757:
1753:
1746:
1738:
1734:
1730:
1726:
1722:
1718:
1714:
1710:
1706:
1702:
1695:
1687:
1683:
1678:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1638:
1636:
1627:
1623:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1578:
1576:
1569:
1563:
1555:
1549:
1541:
1537:
1533:
1529:
1526:(8): 350â61.
1525:
1521:
1514:
1506:
1502:
1497:
1492:
1488:
1484:
1480:
1476:
1472:
1465:
1457:
1453:
1450:(3): 362â71.
1449:
1445:
1441:
1434:
1426:
1422:
1416:
1408:
1404:
1398:
1391:
1387:
1382:
1380:
1378:
1370:
1366:
1361:
1359:
1357:
1352:
1341:
1337:
1334:
1330:
1329:
1323:
1321:
1311:
1307:
1305:
1300:
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1273:
1268:
1263:
1255:
1253:
1249:
1245:
1241:
1238:
1234:
1230:
1218:
1213:
1209:
1205:
1202:
1198:
1191:
1189:
1186:
1182:
1178:
1174:
1171:
1167:
1163:
1156:
1154:
1150:
1146:
1140:
1136:
1133:
1127:
1125:
1121:
1115:
1111:
1108:
1104:
1097:
1095:
1091:
1087:
1081:
1077:
1074:
1068:
1066:
1062:
1056:
1052:
1049:
1047:RefSeq (mRNA)
1045:
1038:
1037:
1032:
1028:
1025:
1019:
1018:
1013:
1009:
1006:
1004:
1000:
993:
992:
987:
983:
980:
974:
973:
968:
964:
961:
959:
955:
948:
947:
942:
938:
935:
929:
928:
923:
919:
916:
914:
910:
907:
904:
902:
899:
895:
892:
888:
884:
877:
873:
868:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
773:
771:
768:
767:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
717:
715:
712:
711:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
666:
664:
661:
660:
657:
656:Gene ontology
653:
649:
637:
632:
628:
623:
620:
618:
614:
606:
601:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
553:
550:
546:
541:
538:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
491:
488:
484:
479:
476:
475:
472:
470:
466:
464:
463:
459:
458:
455:
453:
449:
445:
441:
437:
429:
424:
420:
416:
411:
401:
397:
390:
383:
377:
370:
362:
358:
354:
349:
345:
340:
336:
328:
323:
319:
315:
310:
300:
296:
289:
282:
276:
269:
265:
259:
255:
251:
246:
242:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
185:
180:
173:
168:
163:
152:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
4192:
3621:
3541:
3519:
3497:
3344:
3307:
3270:
3223:
3193:
3166:
2988:
2894:
2742:
2471:
2223:
2019:
2015:
1986:
1982:
1936:
1932:
1922:
1913:
1904:
1867:
1863:
1852:
1819:
1815:
1800:. Fall 2006.
1797:
1788:
1755:
1751:
1745:
1704:
1700:
1694:
1651:
1647:
1591:
1587:
1562:
1548:
1523:
1519:
1513:
1478:
1474:
1464:
1447:
1443:
1433:
1424:
1415:
1406:
1397:
1317:
1308:
1301:
1270:
1264:
1261:
1243:
1236:
1228:
1227:
1149:NP_001300690
1145:NP_001300689
1142:
1117:
1094:NM_001313761
1090:NM_001313760
1083:
1058:
1034:
1015:
989:
970:
944:
925:
905:
900:
467:
460:
426:166,047,325
413:166,025,692
187:External IDs
78:
2022:(1): 1â13.
679:RNA binding
669:DNA binding
555:granulocyte
513:bone marrow
501:granulocyte
405:X|X F5
325:12,923,169
312:12,906,620
165:Identifiers
4332:Categories
2106:(see also
1392:, May 2017
1371:, May 2017
1347:References
1293:leukocytes
1272:Drosophila
591:blastocyst
471:(ortholog)
208:HomoloGene
1844:232141585
1798:invivoGen
1654:: 29447.
1289:cytokines
1153:NP_573475
1124:NP_619542
1120:NP_057694
1086:NM_133212
1065:NM_138636
1061:NM_016610
891:Orthologs
579:esophagus
216:GeneCards
2100:Proteins
2038:11909637
2003:11782555
1963:30100350
1896:18927625
1836:33678093
1780:32208414
1772:25599397
1737:11952027
1729:16123302
1686:27385120
1618:14976262
1540:22817608
1505:20811154
1456:11022119
1388:–
1367:–
1340:CU-CPT9a
1333:VTX-2337
1258:Function
1201:Wikidata
870:Sources:
725:membrane
575:calvaria
521:appendix
493:monocyte
3908:301â350
3702:251â300
3654:CD240CE
3451:201â250
3135:151â200
2858:101â150
2063:PDBe-KB
1954:6195466
1887:2568981
1709:Bibcode
1701:Science
1677:4935957
1656:Bibcode
1626:1680581
1596:Bibcode
1588:Science
1496:2947223
1390:Ensembl
1369:Ensembl
1233:protein
1003:UniProt
958:Ensembl
897:Species
876:QuickGO
446:pattern
204:2176887
172:Aliases
4312:TOLLIP
4302:TICAM1
4287:MAP3K7
3915:CD300A
3874:CDw293
3659:CD240D
3520:CD213a
3498:CDw210
3463:CD202b
3437:CDw199
3432:CDw198
3086:CD140b
2518:51â100
2059:(MeSH)
2036:
2001:
1961:
1951:
1894:
1884:
1842:
1834:
1778:
1770:
1735:
1727:
1684:
1674:
1624:
1616:
1538:
1503:
1493:
1454:
1277:humans
1187:search
1185:PubMed
1036:P58682
1017:Q9NR97
946:170744
913:Entrez
617:BioGPS
587:spleen
563:embryo
559:zygote
517:spleen
304:Xp22.2
196:300366
4317:TRAF6
4307:TIRAP
4292:MYD88
4277:IRAK4
4272:IRAK3
4267:IRAK2
4262:IRAK1
4218:TLR13
4213:TLR12
4208:TLR11
4203:TLR10
4095:CD350
4090:CD349
4085:CD344
4080:CD340
4075:CD339
4070:CD338
4065:CD337
4060:CD336
4055:CD335
4050:CD334
4045:CD333
4040:CD332
4035:CD331
4030:CD329
4025:CD328
4020:CD327
4015:CD326
4010:CD325
4005:CD324
4000:CD322
3995:CD321
3990:CD320
3985:CD318
3980:CD317
3975:CD316
3970:CD315
3965:CD314
3960:CD312
3955:CD309
3950:CD307
3945:CD306
3940:CD305
3935:CD304
3930:CD303
3925:CD302
3920:CD301
3899:CD299
3894:CD298
3889:CD297
3884:CD295
3879:CD294
3869:CD292
3864:CD290
3859:CD289
3854:CD288
3849:CD286
3844:CD284
3839:CD283
3834:CD282
3829:CD281
3824:CD280
3819:CD279
3814:CD278
3809:CD276
3804:CD275
3799:CD274
3794:CD273
3789:CD272
3784:CD271
3779:CD269
3774:CD268
3769:CD267
3764:CD266
3759:CD265
3754:CD264
3749:CD263
3744:CD262
3739:CD261
3734:CD258
3729:CD257
3724:CD256
3719:CD254
3714:CD253
3709:CD252
3693:CD249
3688:CD248
3684:CD247
3679:CD246
3674:CD244
3669:CD243
3664:CD241
3649:CD239
3644:CD238
3639:CD236
3622:CD235
3617:CD234
3612:CD233
3607:CD230
3602:CD229
3597:CD228
3592:CD227
3587:CD226
3582:CD225
3577:CD224
3572:CD223
3567:CD222
3562:CD221
3557:CD220
3542:CD218
3537:CD217
3515:CD212
3493:CD209
3488:CD208
3483:CD207
3478:CD206
3473:CD205
3468:CD204
3458:CD201
3442:CD200
3427:CD197
3422:CD196
3417:CD195
3412:CD194
3407:CD193
3402:CD192
3397:CD191
3392:CD186
3387:CD185
3382:CD184
3377:CD183
3372:CD182
3367:CD181
3362:CD180
3345:CD179
3340:CD178
3335:CD177
3330:CD174
3308:CD172
3303:CD171
3298:CD170
3293:CD169
3288:CD168
3271:CD167
3266:CD166
3261:CD164
3256:CD163
3251:CD162
3246:CD161
3241:CD160
3224:CD159
3194:CD158
3189:CD157
3167:CD156
3162:CD155
3157:CD154
3152:CD153
3147:CD152
3142:CD151
3126:CD150
3121:CD148
3116:CD147
3111:CD146
3106:CD144
3101:CD143
3096:CD142
3091:CD141
3081:CD138
3076:CD137
3071:CD136
3066:CD135
3061:CD134
3056:CD133
3051:CD132
3046:CD131
3041:CD130
3036:CD129
3031:CD127
3026:CD126
3021:CD125
3016:CD124
3011:CD123
3006:CD122
2989:CD121
2972:CD120
2967:CD119
2962:CD118
2957:CD117
2952:CD116
2947:CD115
2942:CD114
2937:CD113
2932:CD112
2927:CD111
2922:CD110
2917:CD109
2912:CD108
2895:CD107
2890:CD106
2885:CD105
2880:CD104
2875:CD103
2870:CD102
2865:CD101
2849:CD100
1840:S2CID
1776:S2CID
1733:S2CID
1622:S2CID
1244:CD288
1231:is a
927:51311
906:Mouse
901:Human
872:Amigo
497:blood
469:Mouse
462:Human
409:Start
344:Mouse
308:Start
241:Human
212:44054
4297:TAB1
4282:IRF3
4234:CD14
4198:TLR9
4193:TLR8
4188:TLR7
4183:TLR6
4178:TLR5
4173:TLR4
4168:TLR3
4163:TLR2
4158:TLR1
4150:TLRs
2844:CD99
2839:CD98
2834:CD97
2829:CD96
2824:CD95
2819:CD94
2814:CD93
2809:CD92
2805:CD91
2800:CD90
2795:CD89
2790:CD88
2785:CD87
2780:CD86
2743:CD85
2738:CD84
2733:CD83
2728:CD82
2723:CD81
2718:CD80
2701:CD79
2696:CD78
2691:CD74
2686:CD73
2681:CD72
2676:CD71
2671:CD70
2666:CD69
2661:CD68
2624:CD66
2602:CD64
2597:CD63
2575:CD62
2570:CD61
2565:CD59
2560:CD58
2555:CD57
2550:CD56
2545:CD55
2540:CD54
2535:CD53
2530:CD52
2525:CD51
2509:CD50
2472:CD49
2467:CD48
2462:CD47
2457:CD46
2452:CD45
2447:CD44
2442:CD43
2415:CD42
2410:CD41
2405:CD40
2400:CD39
2395:CD38
2390:CD37
2385:CD36
2380:CD35
2375:CD34
2370:CD33
2353:CD32
2348:CD31
2343:CD30
2338:CD29
2333:CD28
2328:CD27
2323:CD26
2318:CD25
2313:CD24
2308:CD23
2303:CD22
2298:CD21
2293:CD20
2288:CD19
2283:CD18
2266:CD16
2261:CD15
2256:CD14
2251:CD13
2224:CD11
2219:CD10
2116:1â50
2034:PMID
2020:1589
1999:PMID
1959:PMID
1892:PMID
1832:PMID
1768:PMID
1725:PMID
1682:PMID
1614:PMID
1536:PMID
1501:PMID
1452:PMID
1297:TLR7
1240:gene
1237:TLR8
452:Bgee
400:Band
361:Chr.
299:Band
258:Chr.
220:TLR8
192:OMIM
179:TLR8
149:5AWA
145:5HDH
141:5AWD
137:5AWB
133:4R6A
129:4R0A
125:4R09
121:4R08
117:4R07
113:4QC0
109:4QBZ
105:3WN4
101:3W3N
97:3W3M
93:3W3L
89:3W3K
85:3W3J
81:3W3G
62:RCSB
59:PDBe
33:TLR8
18:TLR8
4244:MD2
4239:LBP
4141:TLR
2214:CD9
2202:CD8
2197:CD7
2192:CD6
2187:CD5
2182:CD4
2160:CD3
2155:CD2
2128:a-c
2123:CD1
2024:doi
1991:doi
1949:PMC
1941:doi
1882:PMC
1872:doi
1824:doi
1760:doi
1717:doi
1705:309
1672:PMC
1664:doi
1604:doi
1592:303
1528:doi
1491:PMC
1483:doi
1479:120
1275:to
422:End
321:End
224:OMA
200:MGI
52:PDB
4334::
4139::
3686:-
2807:-
2148:1E
2143:1D
2138:1B
2133:1A
2102::
2032:.
2018:.
2014:.
1997:.
1987:30
1985:.
1957:.
1947:.
1937:25
1935:.
1931:.
1912:.
1890:.
1880:.
1866:.
1862:.
1838:.
1830:.
1820:16
1818:.
1806:^
1796:.
1774:.
1766:.
1756:22
1754:.
1731:.
1723:.
1715:.
1703:.
1680:.
1670:.
1662:.
1650:.
1646:.
1634:^
1620:.
1612:.
1602:.
1590:.
1586:.
1574:^
1534:.
1524:32
1522:.
1499:.
1489:.
1477:.
1473:.
1448:11
1446:.
1442:.
1423:.
1405:.
1376:^
1355:^
1322:.
874:/
428:bp
415:bp
327:bp
314:bp
222:;
218::
214:;
210::
206:;
202::
198:;
194::
147:,
143:,
139:,
135:,
131:,
127:,
123:,
119:,
115:,
111:,
107:,
103:,
99:,
95:,
91:,
87:,
83:,
4129:e
4122:t
4115:v
3632:b
3627:a
3553:)
3551:b
3546:a
3544:(
3530:2
3525:1
3508:b
3503:a
3355:b
3350:a
3323:g
3318:b
3313:a
3281:b
3276:a
3234:c
3229:a
3220:)
3218:k
3213:i
3208:e
3203:d
3198:a
3196:(
3182:c
3177:b
3172:a
2999:b
2994:a
2982:b
2977:a
2905:b
2900:a
2773:k
2768:j
2763:h
2758:e
2753:d
2748:a
2711:b
2706:a
2654:f
2649:e
2644:d
2639:c
2634:b
2629:a
2617:C
2612:B
2607:A
2590:P
2585:L
2580:E
2502:f
2497:e
2492:d
2487:c
2482:b
2477:a
2435:d
2430:c
2425:b
2420:a
2363:B
2358:A
2276:B
2271:A
2244:d
2239:c
2234:b
2229:a
2207:a
2175:Δ
2170:ÎŽ
2165:Îł
2110:)
2092:e
2085:t
2078:v
2040:.
2026::
2005:.
1993::
1965:.
1943::
1898:.
1874::
1868:4
1846:.
1826::
1782:.
1762::
1739:.
1719::
1711::
1688:.
1666::
1658::
1652:6
1628:.
1606::
1598::
1556:.
1542:.
1530::
1507:.
1485::
1458:.
1427:.
1409:.
1246:(
346:)
243:)
226::
20:)
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