310:
287:
209:
184:
561:
316:
215:
1205:(IBD), since TLR5 expression on intestinal epithelial cells (IEC's) are important for maintaining the composition of intestinal microbiota. Additionally, TLR5-deficient mice develop spontaneous colitis and metabolic syndrome which are associated with altered gut microbiota. Statistically significant lower levels of TLR5 expression have been found in patients exhibiting moderate to severe
1187:
level in senescent cells, TLR5 expression maintains relatively stable during the aging process, which is correlated with the high level of
Caveolin-1 in aging cells. Data from Caveolin-1 knockout mice demonstrated that TLR5 expression significantly decreases in the absence of Caveolin-1 expression in
1122:
TLR5 recognizes bacterial flagellin, the protein monomer of bacterial flagella and a virulence factor. Flagellin are found on nearly all motile bacteria and contains regions that are highly conserved among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as
1106:
to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns
63:
1073:
due to the high expression of TLR in intestinal lamina propria dendritic cells. Recent studies have also shown that malfunctioning of TLR5 is likely related to rheumatoid arthritis, osteoclastogenesis, and bone loss. Abnormal TLR5 functioning is related to the onset of
1167:
induces many downstream gene expressions, which initiates the canonical proinflammatory pathway. This TLR5/flagellum interaction results in different responses in difference cell types. In epithelial cells, binding of flagellum to TLR5 induces
1952:
Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, et al. (December 2003). "Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility".
1217:
Bone loss and osteoclastogenesis are induced by inflammation in infectious and autoimmune diseases. A recent study has identified TLR5 as a novel mediator in the process of inflammation-induced bone loss and osteoclastogenesis.
1312:
induced inflammation and subsequent cervical neoplasia formation. TLR5 is generally absent in normal cervical squamous epithelium. However, a gradually increased level of TLR5 expression has been detected in low-grade
323:
222:
1535:
Stanislawowski M, Wierzbicki PM, Golab A, Adrych K, Kartanowicz D, Wypych J, et al. (October 2009). "Decreased Toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients".
2202:"Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling"
2581:
Pimentel-Nunes P, Afonso L, Lopes P, Roncon-Albuquerque R, Gonçalves N, Henrique R, et al. (September 2011). "Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia".
2728:
Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. (April 2001). "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5".
1901:
Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. (April 2001). "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5".
2501:"Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells"
1563:
Nagai Y, Takatsu K (10 March 2014). "Chapter 26 - Role of the Immune System in
Obesity-Associated Inflammation and Insulin Resistance". In Watson RR (ed.).
784:
145:
765:
1598:"Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis"
1489:
Miao EA, Andersen-Nissen E, Warren SE, Aderem A (September 2007). "TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system".
2624:
Lee JW, Choi JJ, Seo ES, Kim MJ, Kim WY, Choi CH, et al. (November 2007). "Increased toll-like receptor 9 expression in cervical neoplasia".
2841:
1209:(UC). In these patients, lower TLR5 mRNA levels were found along with decreased immunoreactivity of TLR5 in the inflamed mucosa of UC patients.
1409:
1391:
1647:"Gene expression profiling meta-analysis reveals novel gene signatures and pathways shared between tuberculosis and rheumatoid arthritis"
60:
1188:
aging cells. It is hypothesized that the
Caveolin-1 directly interacts with TLR5 to stabilize it and hence increases the level of TLR5.
984:
991:
2161:"Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells"
1811:
Husseinzadeh N, Davenport SM (November 2014). "Role of toll-like receptors in cervical, endometrial and ovarian cancers: a review".
1172:
production. In human monocytes and dendritic cells, this interaction results in the secretion of proinflammatory cytokines such as
1111:, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor
1887:
2057:"Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression"
1234:(RANKL). Activation of RANKL leads to increased expression of osteoclastic genes. Activation of these genes results in robust
1580:
1374:
3051:
2834:
1353:
2967:
2952:
1333:
cell lines but not in ovarian stroma, suggesting a possible role of TLR5 in inflammation induced ovarian cancer onset.
1314:
1260:
being one of the most common resources of infection. TLR5 is an essential factor in inducing inflammatory response to
309:
1378:
1357:
286:
1131:
production. However, some
Proteobacteria flagella have acquired mutations preventing their recognition by TLR5.
2827:
829:
1288:
factor is responsible for this response In addition to inflammation induction, TLR5 is also shown to enhance
810:
3056:
1143:
to TLR5 on the cell surface. Binding of flagellum induces the dimerization of TLR5, which in turn recruits
208:
183:
125:
1128:
1116:
1069:
from invading mobile bacteria. It has been shown to be involved in the onset of many diseases, including
2442:
Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, et al. (April 2010).
1202:
1070:
322:
221:
315:
214:
112:
2813:
1996:
Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, et al. (June 2005).
1159:, and eventually IκB kinases. Activation of IκB kinases contributes to the nuclear localization of
133:
2809:
1107:
of expression. TLR5 is expressed on both immune and non-immune cells. TLR5 recognizes bacterial
967:
946:
920:
899:
1173:
2667:
Zhou M, McFarland-Mancini MM, Funk HM, Husseinzadeh N, Mounajjed T, Drew AF (September 2009).
3061:
2957:
2921:
2916:
2911:
2906:
2901:
2896:
2886:
2881:
2876:
2871:
2819:
2737:
2542:"Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5"
2455:
2009:
1910:
1658:
1440:
1309:
1227:
1099:
197:
17:
2106:"PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment"
1596:
Kim SJ, Chen Z, Chamberlain ND, Essani AB, Volin MV, Amin MA, et al. (October 2014).
153:
8:
2850:
1256:
2741:
2693:
2668:
2459:
2013:
1914:
1662:
1444:
2931:
2926:
2863:
2854:
2761:
2706:
2649:
2606:
2499:
Smith MF, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, et al. (August 2003).
2476:
2443:
2419:
2394:
2370:
2343:
2319:
2294:
2132:
2105:
2086:
2032:
1997:
1978:
1934:
1785:
1758:
1681:
1646:
1622:
1597:
1572:
1514:
1206:
1083:
1062:
157:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
633:
628:
623:
607:
602:
2790:
2786:
2753:
2698:
2641:
2598:
2563:
2522:
2481:
2424:
2375:
2324:
2272:
2267:
2242:
2223:
2182:
2137:
2078:
2037:
1970:
1926:
1869:
1828:
1790:
1734:
1686:
1627:
1576:
1545:
1506:
1468:
1463:
1428:
1329:
It has been reported that TLR5 expression is detected in both ovarian epithelium and
105:
53:
2710:
2653:
2444:"Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5"
2258:
2090:
1713:"TLR5, a novel mediator of innate immunity-induced osteoclastogenesis and bone loss"
1518:
1276:
only induces weak TLR5 activation. The inflammatory response induced by TLR5 during
137:
2782:
2765:
2745:
2688:
2680:
2633:
2590:
2553:
2512:
2471:
2463:
2414:
2406:
2365:
2355:
2314:
2306:
2262:
2254:
2243:"Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin"
2213:
2172:
2127:
2117:
2068:
2027:
2017:
1982:
1962:
1938:
1918:
1859:
1848:"Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells"
1820:
1780:
1770:
1724:
1676:
1666:
1617:
1609:
1568:
1498:
1458:
1448:
1293:
402:
333:
277:
232:
2610:
2410:
1296:. This is supported by the increased level of TLR5 expression from normal gastric
1098:
The TLR family plays a fundamental role in pathogen recognition and activation of
1671:
1321:. However, the exact mechanism of interaction between TLR5 and HPV is not known.
1318:
1297:
1079:
377:
161:
2310:
2218:
2201:
2073:
2056:
1824:
1414:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1396:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2156:
2002:
Proceedings of the
National Academy of Sciences of the United States of America
1433:
Proceedings of the
National Academy of Sciences of the United States of America
1330:
1289:
1223:
1087:
1075:
478:
2684:
2594:
1502:
3045:
2395:"Proneness of TLR5 deficient mice to develop colitis is microbiota dependent"
2360:
1775:
1613:
1238:
formation and bone loss. This process is absent in TLR5 knockout mice model.
1169:
1139:
The TLR5 signaling cascade is commonly triggered by the binding of bacterial
589:
2467:
2022:
538:
416:
2794:
2757:
2702:
2645:
2602:
2580:
2567:
2540:
Song EJ, Kang MJ, Kim YS, Kim SM, Lee SE, Kim CH, et al. (July 2011).
2526:
2517:
2500:
2485:
2428:
2379:
2328:
2276:
2227:
2186:
2177:
2160:
2141:
2082:
2041:
1974:
1930:
1873:
1832:
1794:
1738:
1690:
1631:
1549:
1510:
1251:
560:
395:
174:
2558:
2541:
1472:
1453:
1183:
as a potential regulator of TLR5 expression. In contrast to the decreased
1147:
and Mal/TIRAP. The recruitment of MyD88 leads to subsequent activation of
1031:
1026:
2122:
1729:
1712:
1230:. Activation of TLR5 in these patients leads to subsequent activation of
874:
855:
1864:
1847:
1711:
Kassem A, Henning P, Kindlund B, Lindholm C, Lerner UH (November 2015).
1254:
in GI tract has been known to increase the risk of gastric cancer, with
1427:
Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (January 1998).
1235:
1180:
1103:
294:
191:
141:
2293:
Lim JS, Nguyen KC, Han JM, Jang IS, Fabian C, Cho KA (December 2015).
82:
2749:
2666:
2637:
2393:
Singh V, Yeoh BS, Carvalho F, Gewirtz AT, Vijay-Kumar M (July 2015).
2055:
Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL (August 2001).
1922:
1429:"A family of human receptors structurally related to Drosophila Toll"
1281:
1268:
are required for the activation of proinflammatory cytokines such as
1219:
1140:
1108:
1066:
729:
361:
348:
260:
247:
149:
1966:
1534:
1123:
TLR5. The activation of this receptor mobilizes the nuclear factor
1015:
2669:"Toll-like receptor expression in normal ovary and ovarian tumors"
2441:
1269:
1164:
1160:
1124:
1112:
1995:
1951:
1756:
1264:
infection. During infection, expression and ligation of TLR5 and
1051:
841:
796:
714:
710:
129:
3025:
3015:
3000:
1488:
999:
751:
569:
1565:
Nutrition in the
Prevention and Treatment of Abdominal Obesity
3030:
3020:
3005:
2990:
2985:
2980:
2975:
1710:
1231:
1156:
1152:
1148:
1144:
2849:
1757:
Castaño-Rodríguez N, Kaakoush NO, Mitchell HM (2014-01-01).
3010:
2995:
2947:
1426:
1265:
1184:
1058:
660:
positive regulation of toll-like receptor signaling pathway
2773:
Lien E, Ingalls RR (January 2002). "Toll-like receptors".
2104:
Choi YJ, Jung J, Chung HK, Im E, Rhee SH (January 2013).
2054:
1998:"Evasion of Toll-like receptor 5 by flagellated bacteria"
1752:
1750:
1748:
2392:
1595:
385:
2727:
2342:
Lu Y, Li X, Liu S, Zhang Y, Zhang D (30 January 2018).
2154:
1900:
1745:
1810:
1530:
1528:
550:
2344:"Toll-like Receptors and Inflammatory Bowel Disease"
2295:"Direct Regulation of TLR5 Expression by Caveolin-1"
1806:
1804:
670:
MyD88-dependent toll-like receptor signaling pathway
2574:
2498:
2199:
1222:, which is a TLR5-activating ligand, is present in
1212:
1134:
1065:(TLR) family. TLR5 is known to recognize bacterial
1759:"Pattern-recognition receptors and gastric cancer"
1525:
1370:
1368:
1366:
1349:
1347:
1345:
1845:
1801:
332:
231:
116:, MELIOS, SLE1, SLEB1, TIL3, toll like receptor 5
3043:
2435:
2292:
2200:Gohda J, Matsumura T, Inoue J (September 2004).
2103:
1363:
1342:
685:positive regulation of interleukin-8 production
2539:
1706:
1704:
1702:
1700:
1375:GRCm38: Ensembl release 89: ENSMUSG00000079164
2835:
2623:
1308:TLR5 is suggested to be possibly involved in
1196:
2341:
2240:
1945:
1894:
1562:
2772:
2546:International Journal of Molecular Medicine
2288:
2286:
1846:Sharma N, Akhade AS, Qadri A (April 2013).
1697:
1484:
1482:
1354:GRCh38: Ensembl release 89: ENSG00000187554
1284:independent. This suggests that an unknown
2842:
2828:
2386:
2193:
1644:
1420:
650:positive regulation of cytokine production
2812:at the U.S. National Library of Medicine
2692:
2557:
2533:
2516:
2475:
2418:
2369:
2359:
2318:
2266:
2217:
2176:
2131:
2121:
2072:
2031:
2021:
1863:
1784:
1774:
1728:
1680:
1670:
1638:
1621:
1462:
1452:
603:transmembrane signaling receptor activity
2283:
1888:"Entrez Gene: TLR5 toll-like receptor 5"
1479:
1191:
690:cellular response to mechanical stimulus
14:
3044:
2241:Moors MA, Li L, Mizel SB (July 2001).
1538:Journal of Physiology and Pharmacology
675:toll-like receptor 5 signaling pathway
2823:
337:
298:
293:
236:
195:
190:
1317:(CIN), high grade CIN, and invasive
2505:The Journal of Biological Chemistry
2165:The Journal of Biological Chemistry
24:
2720:
1589:
1573:10.1016/B978-0-12-407869-7.00026-X
1315:cervical intraepithelial neoplasia
1280:is also considered to be possibly
1232:receptor activator of NF-κB ligand
1054:which in humans is encoded by the
25:
3073:
2803:
2583:Pathology & Oncology Research
1272:. However, TLR5 interaction with
1102:. TLRs are highly conserved from
2787:10.1097/00003246-200201001-00001
2673:Cancer Immunology, Immunotherapy
1213:Osteoclastogenesis and bone loss
1135:Signaling pathway and regulation
559:
321:
314:
308:
285:
220:
213:
207:
182:
2660:
2617:
2492:
2335:
2259:10.1128/IAI.69.7.4424-4429.2001
2234:
2148:
2097:
2048:
1989:
1880:
1839:
451:epithelium of lactiferous gland
1608:(8). Baltimore, Md.: 3902–13.
1556:
1402:
1384:
1292:cell proliferation through an
1163:(a proinflammatory cytokine).
624:integral component of membrane
608:interleukin-1 receptor binding
570:More reference expression data
539:More reference expression data
13:
1:
2411:10.1080/19490976.2015.1060390
2159:, Pothoulakis C (July 2006).
1336:
665:defense response to bacterium
306:
205:
1852:Journal of Leukocyte Biology
1672:10.1371/journal.pone.0213470
1179:Recent study has identified
7:
3052:Genes on human chromosome 1
2311:10.14348/molcells.2015.0213
2219:10.4049/jimmunol.173.5.2913
2074:10.4049/jimmunol.167.4.1882
1825:10.1016/j.ygyno.2014.08.013
1491:Seminars in Immunopathology
1303:
1129:tumor necrosis factor-alpha
1117:tumor necrosis factor-alpha
1093:
10:
3078:
1645:Badr MT, Häcker G (2019).
1324:
1246:
1203:inflammatory bowel disease
1197:Inflammatory bowel disease
1071:Inflammatory bowel disease
2966:
2940:
2862:
2685:10.1007/s00262-008-0650-y
2595:10.1007/s12253-011-9368-9
1503:10.1007/s00281-007-0078-z
1410:"Mouse PubMed Reference:"
1392:"Human PubMed Reference:"
1300:to gastric cancer cells.
1241:
1030:
1025:
1021:
1014:
998:
985:Chr 1: 223.11 – 223.14 Mb
979:
964:
960:
943:
939:
932:
917:
913:
896:
892:
885:
872:
868:
853:
849:
840:
827:
823:
808:
804:
795:
782:
778:
763:
759:
750:
735:
728:
724:
708:
588:
584:
567:
558:
549:
536:
485:
476:
463:mucosa of paranasal sinus
443:bronchial epithelial cell
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
79:
74:
57:
52:
47:
43:
39:
34:
2814:Medical Subject Headings
2626:Molecular Carcinogenesis
2361:10.3389/fimmu.2018.00072
1776:10.3389/fimmu.2014.00336
1614:10.4049/jimmunol.1302998
1201:TLR5 may play a role in
1061:. It is a member of the
992:Chr 1: 182.78 – 182.8 Mb
2468:10.1126/science.1179721
2348:Frontiers in Immunology
2023:10.1073/pnas.0502040102
1763:Frontiers in Immunology
29:Protein found in humans
2775:Critical Care Medicine
2518:10.1074/jbc.M305536200
2247:Infection and Immunity
2178:10.1074/jbc.M513861200
695:innate immune response
435:epithelium of bronchus
2968:Downstream signalling
2559:10.3892/ijmm.2011.656
2206:Journal of Immunology
2061:Journal of Immunology
1602:Journal of Immunology
1454:10.1073/pnas.95.2.588
1294:ERK-dependent pathway
1192:Clinical significance
700:inflammatory response
680:immune system process
2810:Toll-Like+Receptor+5
2123:10.1096/fj.12-217596
1813:Gynecologic Oncology
1730:10.1096/fj.15-272559
1567:. pp. 281–293.
1252:Chronic inflammation
1228:rheumatoid arthritis
1044:Toll-like receptor 5
339:1 H5|1 86.12 cM
300:Chromosome 1 (mouse)
198:Chromosome 1 (human)
75:List of PDB id codes
48:Available structures
3057:Toll-like receptors
2742:2001Natur.410.1099H
2460:2010Sci...328..228V
2299:Molecules and Cells
2014:2005PNAS..102.9247A
1915:2001Natur.410.1099H
1865:10.1189/jlb.0712328
1663:2019PLoSO..1413470B
1445:1998PNAS...95..588R
1226:from patients with
655:signal transduction
2781:(1 Suppl): S1-11.
2736:(6832): 1099–103.
1909:(6832): 1099–103.
1207:ulcerative colitis
1063:toll-like receptor
830:ENSMUSG00000079164
643:Biological process
617:Cellular component
596:Molecular function
459:lower lobe of lung
3039:
3038:
2857:signaling pathway
2851:Signaling pathway
1955:Nature Immunology
1582:978-0-12-407869-7
1544:(Suppl 4): 71–5.
1041:
1040:
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928:
927:
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906:
881:
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862:
861:
836:
835:
817:
816:
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790:
772:
771:
720:
719:
580:
579:
576:
575:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
94:
93:
90:
89:
58:Ortholog search:
16:(Redirected from
3069:
2844:
2837:
2830:
2821:
2820:
2798:
2769:
2750:10.1038/35074106
2715:
2714:
2696:
2664:
2658:
2657:
2638:10.1002/mc.20325
2621:
2615:
2614:
2578:
2572:
2571:
2561:
2537:
2531:
2530:
2520:
2511:(35): 32552–60.
2496:
2490:
2489:
2479:
2454:(5975): 228–31.
2439:
2433:
2432:
2422:
2390:
2384:
2383:
2373:
2363:
2339:
2333:
2332:
2322:
2290:
2281:
2280:
2270:
2238:
2232:
2231:
2221:
2197:
2191:
2190:
2180:
2155:Rhee SH, Kim H,
2152:
2146:
2145:
2135:
2125:
2101:
2095:
2094:
2076:
2052:
2046:
2045:
2035:
2025:
1993:
1987:
1986:
1949:
1943:
1942:
1923:10.1038/35074106
1898:
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1808:
1799:
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1554:
1553:
1532:
1523:
1522:
1486:
1477:
1476:
1466:
1456:
1424:
1418:
1417:
1406:
1400:
1399:
1388:
1382:
1372:
1361:
1351:
1046:, also known as
1023:
1022:
994:
987:
970:
958:
957:
949:
937:
936:
933:RefSeq (protein)
923:
911:
910:
902:
890:
889:
866:
865:
847:
846:
821:
820:
802:
801:
776:
775:
757:
756:
726:
725:
586:
585:
572:
563:
556:
555:
541:
505:secondary oocyte
481:
479:Top expressed in
474:
473:
455:lactiferous duct
419:
417:Top expressed in
412:
411:
391:
390:
374:
373:
364:
351:
340:
325:
318:
312:
301:
289:
273:
272:
263:
250:
239:
224:
217:
211:
200:
186:
170:
169:
164:
162:TLR5 - orthologs
115:
108:
85:
72:
71:
66:
45:
44:
32:
31:
21:
3077:
3076:
3072:
3071:
3070:
3068:
3067:
3066:
3042:
3041:
3040:
3035:
2962:
2941:Other receptors
2936:
2858:
2848:
2806:
2801:
2723:
2721:Further reading
2718:
2665:
2661:
2622:
2618:
2579:
2575:
2538:
2534:
2497:
2493:
2440:
2436:
2391:
2387:
2340:
2336:
2291:
2284:
2239:
2235:
2198:
2194:
2171:(27): 18560–8.
2153:
2149:
2102:
2098:
2053:
2049:
2008:(26): 9247–52.
1994:
1990:
1961:(12): 1247–53.
1950:
1946:
1899:
1895:
1886:
1885:
1881:
1844:
1840:
1809:
1802:
1755:
1746:
1723:(11): 4449–60.
1709:
1698:
1657:(3): e0213470.
1643:
1639:
1594:
1590:
1583:
1561:
1557:
1533:
1526:
1487:
1480:
1425:
1421:
1408:
1407:
1403:
1390:
1389:
1385:
1373:
1364:
1352:
1343:
1339:
1327:
1319:cervical cancer
1306:
1249:
1244:
1215:
1199:
1194:
1137:
1127:and stimulates
1115:and stimulates
1100:innate immunity
1096:
1088:ovarian cancers
1032:View/Edit Mouse
1027:View/Edit Human
990:
983:
980:Location (UCSC)
966:
945:
919:
898:
811:ENSG00000187554
704:
638:
634:plasma membrane
612:
568:
537:
528:
525:muscle of thigh
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
81:
59:
30:
23:
22:
15:
12:
11:
5:
3075:
3065:
3064:
3059:
3054:
3037:
3036:
3034:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
2998:
2993:
2988:
2983:
2978:
2972:
2970:
2964:
2963:
2961:
2960:
2955:
2950:
2944:
2942:
2938:
2937:
2935:
2934:
2929:
2924:
2919:
2914:
2909:
2904:
2899:
2894:
2889:
2884:
2879:
2874:
2868:
2866:
2860:
2859:
2847:
2846:
2839:
2832:
2824:
2818:
2817:
2805:
2804:External links
2802:
2800:
2799:
2770:
2724:
2722:
2719:
2717:
2716:
2679:(9): 1375–85.
2659:
2616:
2573:
2532:
2491:
2434:
2385:
2334:
2305:(12): 1111–7.
2282:
2233:
2192:
2147:
2096:
2047:
1988:
1967:10.1038/ni1011
1944:
1893:
1879:
1838:
1800:
1744:
1696:
1637:
1588:
1581:
1555:
1524:
1478:
1419:
1401:
1383:
1362:
1340:
1338:
1335:
1331:ovarian cancer
1326:
1323:
1305:
1302:
1290:gastric cancer
1248:
1245:
1243:
1240:
1224:synovial fluid
1214:
1211:
1198:
1195:
1193:
1190:
1136:
1133:
1095:
1092:
1039:
1038:
1035:
1034:
1029:
1019:
1018:
1012:
1011:
1008:
1007:
1005:
1003:
996:
995:
988:
981:
977:
976:
973:
972:
962:
961:
955:
952:
951:
941:
940:
934:
930:
929:
926:
925:
915:
914:
908:
905:
904:
894:
893:
887:
883:
882:
879:
878:
870:
869:
863:
860:
859:
851:
850:
844:
838:
837:
834:
833:
825:
824:
818:
815:
814:
806:
805:
799:
793:
792:
789:
788:
780:
779:
773:
770:
769:
761:
760:
754:
748:
747:
742:
737:
733:
732:
722:
721:
718:
717:
706:
705:
703:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
646:
644:
640:
639:
637:
636:
631:
626:
620:
618:
614:
613:
611:
610:
605:
599:
597:
593:
592:
582:
581:
578:
577:
574:
573:
565:
564:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
513:primary oocyte
510:
506:
502:
498:
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
77:
76:
68:
67:
56:
50:
49:
41:
40:
37:
36:
28:
9:
6:
4:
3:
2:
3074:
3063:
3060:
3058:
3055:
3053:
3050:
3049:
3047:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2973:
2971:
2969:
2965:
2959:
2956:
2954:
2951:
2949:
2946:
2945:
2943:
2939:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2869:
2867:
2865:
2861:
2856:
2852:
2845:
2840:
2838:
2833:
2831:
2826:
2825:
2822:
2815:
2811:
2808:
2807:
2796:
2792:
2788:
2784:
2780:
2776:
2771:
2767:
2763:
2759:
2755:
2751:
2747:
2743:
2739:
2735:
2731:
2726:
2725:
2712:
2708:
2704:
2700:
2695:
2690:
2686:
2682:
2678:
2674:
2670:
2663:
2655:
2651:
2647:
2643:
2639:
2635:
2632:(11): 941–7.
2631:
2627:
2620:
2612:
2608:
2604:
2600:
2596:
2592:
2589:(3): 677–83.
2588:
2584:
2577:
2569:
2565:
2560:
2555:
2551:
2547:
2543:
2536:
2528:
2524:
2519:
2514:
2510:
2506:
2502:
2495:
2487:
2483:
2478:
2473:
2469:
2465:
2461:
2457:
2453:
2449:
2445:
2438:
2430:
2426:
2421:
2416:
2412:
2408:
2405:(4): 279–83.
2404:
2400:
2396:
2389:
2381:
2377:
2372:
2367:
2362:
2357:
2353:
2349:
2345:
2338:
2330:
2326:
2321:
2316:
2312:
2308:
2304:
2300:
2296:
2289:
2287:
2278:
2274:
2269:
2264:
2260:
2256:
2253:(7): 4424–9.
2252:
2248:
2244:
2237:
2229:
2225:
2220:
2215:
2212:(5): 2913–7.
2211:
2207:
2203:
2196:
2188:
2184:
2179:
2174:
2170:
2166:
2162:
2158:
2151:
2143:
2139:
2134:
2129:
2124:
2119:
2116:(1): 243–54.
2115:
2111:
2110:FASEB Journal
2107:
2100:
2092:
2088:
2084:
2080:
2075:
2070:
2067:(4): 1882–5.
2066:
2062:
2058:
2051:
2043:
2039:
2034:
2029:
2024:
2019:
2015:
2011:
2007:
2003:
1999:
1992:
1984:
1980:
1976:
1972:
1968:
1964:
1960:
1956:
1948:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1897:
1889:
1883:
1875:
1871:
1866:
1861:
1857:
1853:
1849:
1842:
1834:
1830:
1826:
1822:
1819:(2): 359–63.
1818:
1814:
1807:
1805:
1796:
1792:
1787:
1782:
1777:
1772:
1768:
1764:
1760:
1753:
1751:
1749:
1740:
1736:
1731:
1726:
1722:
1718:
1717:FASEB Journal
1714:
1707:
1705:
1703:
1701:
1692:
1688:
1683:
1678:
1673:
1668:
1664:
1660:
1656:
1652:
1648:
1641:
1633:
1629:
1624:
1619:
1615:
1611:
1607:
1603:
1599:
1592:
1584:
1578:
1574:
1570:
1566:
1559:
1551:
1547:
1543:
1539:
1531:
1529:
1520:
1516:
1512:
1508:
1504:
1500:
1497:(3): 275–88.
1496:
1492:
1485:
1483:
1474:
1470:
1465:
1460:
1455:
1450:
1446:
1442:
1439:(2): 588–93.
1438:
1434:
1430:
1423:
1415:
1411:
1405:
1397:
1393:
1387:
1380:
1376:
1371:
1369:
1367:
1359:
1355:
1350:
1348:
1346:
1341:
1334:
1332:
1322:
1320:
1316:
1311:
1301:
1299:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1258:
1253:
1239:
1237:
1233:
1229:
1225:
1221:
1210:
1208:
1204:
1189:
1186:
1182:
1177:
1175:
1171:
1166:
1162:
1158:
1154:
1150:
1146:
1142:
1132:
1130:
1126:
1120:
1118:
1114:
1110:
1105:
1101:
1091:
1089:
1085:
1081:
1077:
1072:
1068:
1064:
1060:
1057:
1053:
1049:
1045:
1033:
1028:
1024:
1020:
1017:
1013:
1006:
1004:
1001:
997:
993:
989:
986:
982:
978:
971:
969:
963:
959:
956:
950:
948:
942:
938:
935:
931:
924:
922:
916:
912:
909:
903:
901:
895:
891:
888:
886:RefSeq (mRNA)
884:
877:
876:
871:
867:
864:
858:
857:
852:
848:
845:
843:
839:
832:
831:
826:
822:
819:
813:
812:
807:
803:
800:
798:
794:
787:
786:
781:
777:
774:
768:
767:
762:
758:
755:
753:
749:
746:
743:
741:
738:
734:
731:
727:
723:
716:
712:
707:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
609:
606:
604:
601:
600:
598:
595:
594:
591:
590:Gene ontology
587:
583:
571:
566:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
27:
19:
3062:LRR proteins
2891:
2778:
2774:
2733:
2729:
2676:
2672:
2662:
2629:
2625:
2619:
2586:
2582:
2576:
2552:(1): 115–9.
2549:
2545:
2535:
2508:
2504:
2494:
2451:
2447:
2437:
2402:
2399:Gut Microbes
2398:
2388:
2351:
2347:
2337:
2302:
2298:
2250:
2246:
2236:
2209:
2205:
2195:
2168:
2164:
2150:
2113:
2109:
2099:
2064:
2060:
2050:
2005:
2001:
1991:
1958:
1954:
1947:
1906:
1902:
1896:
1882:
1858:(4): 521–8.
1855:
1851:
1841:
1816:
1812:
1766:
1762:
1720:
1716:
1654:
1650:
1640:
1605:
1601:
1591:
1564:
1558:
1541:
1537:
1494:
1490:
1436:
1432:
1422:
1413:
1404:
1395:
1386:
1328:
1307:
1285:
1277:
1273:
1261:
1255:
1250:
1216:
1200:
1178:
1138:
1121:
1119:production.
1097:
1055:
1047:
1043:
1042:
965:
944:
918:
897:
873:
854:
828:
809:
783:
764:
744:
739:
401:
394:
360:182,804,010
347:182,782,353
259:223,143,248
246:223,109,404
121:External IDs
80:
26:
1084:endometrial
489:granulocyte
447:right ovary
99:Identifiers
3046:Categories
2354:(72): 72.
1381:, May 2017
1360:, May 2017
1337:References
1236:osteoclast
1181:Caveolin-1
1104:Drosophila
439:left ovary
405:(ortholog)
142:HomoloGene
1286:H. pylori
1282:flagellin
1278:H. pylori
1274:H. pylori
1262:H. pylori
1257:H. pylori
1220:Flagellin
1141:flagellum
1109:flagellin
1067:flagellin
968:NP_058624
947:NP_003259
921:NM_016928
900:NM_003268
730:Orthologs
150:GeneCards
2795:11782555
2758:11323673
2711:23677988
2703:19184006
2694:11030589
2654:29324508
2646:17440926
2603:21455638
2568:21455558
2527:12807870
2486:20203013
2429:26067589
2380:29441063
2329:26615831
2277:11401982
2228:15322147
2187:16644730
2157:Moyer MP
2142:23038756
2091:23844864
2083:11489966
2042:15956202
1975:14625549
1931:11323673
1874:23345392
1833:25135000
1795:25101079
1739:26207027
1691:30845171
1651:PLOS ONE
1632:25200955
1550:20083854
1519:21209470
1511:17690885
1377:–
1356:–
1304:Cervical
1094:Function
1080:cervical
1016:Wikidata
709:Sources:
629:membrane
501:placenta
427:monocyte
2766:4422702
2738:Bibcode
2477:4714868
2456:Bibcode
2448:Science
2420:4615783
2371:5797585
2320:4697003
2133:3528317
2033:1166605
2010:Bibcode
1983:6157006
1939:4422702
1911:Bibcode
1786:4105827
1769:: 336.
1682:6405138
1659:Bibcode
1623:4185216
1473:9435236
1441:Bibcode
1379:Ensembl
1358:Ensembl
1325:Ovarian
1247:Gastric
1076:gastric
1052:protein
1050:, is a
842:UniProt
797:Ensembl
736:Species
715:QuickGO
380:pattern
138:1858171
106:Aliases
3026:TOLLIP
3016:TICAM1
3001:MAP3K7
2816:(MeSH)
2793:
2764:
2756:
2730:Nature
2709:
2701:
2691:
2652:
2644:
2611:762206
2609:
2601:
2566:
2525:
2484:
2474:
2427:
2417:
2378:
2368:
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