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PPD is an extremely rare disease. In the United States the disease is estimated to affect less than 5,000 people and approximately 1 per million people in the United
Kingdom however it is believed to be more common in Turkey and the Middle East.
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Treatment for PPD is supportive. Anti-inflammatory drugs may be used for pain due to secondary osteoarthritis. More severe joint pain may be treated with surgery. Physical therapy, occupational therapy, may help with joint stiffness.
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gene, which encodes a signalling factor involved in cartilage homeostasis. Genomic changes to the gene result in a non-functional protein, which disrupts cartilage aintenance and bone growth. The disorder is inherited in an
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Bhavani, Gandham SriLakshmi; Shah, Hitesh; Shukla, Anju; Dalal, Ashwin; Girisha, Katta Mohan (1993), Adam, Margaret P.; Everman, David B.; Mirzaa, Ghayda M.; Pagon, Roberta A. (eds.),
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33:(PPD, PPRD), also known as progressive pseudorheumatoid arthropathy of childhood (PPAD), is a disorder of bone and cartilage that affects many joints. The disorder leads to
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Torreggiani, Sofia; Torcoletti, Marta; Campos-Xavier, Belinda; Baldo, Francesco; Agostoni, Carlo; Superti-Furga, Andrea; Filocamo, Giovanni (March 2019).
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396:"Progressive pseudorheumatoid dysplasia with new-found gene mutation of Wntl inducible signaling pathway protein 3"
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Since symptoms of PPD are similar to juvenile rhematoid arthritis, people with PPD may be initially misdiagnosed.
252:"Progressive pseudorheumatoid dysplasia - About the Disease - Genetic and Rare Diseases Information Center"
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Chen, Wenji; Mo, Shiyan; Luo, Gui; Wang, Yanyan; Deng, Xiaohu; Zhu, Jian; Zhao, Wei (2018-09-10).
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and widening of the ends of the finger and toe bones as well as other tubular bones.
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277:"Progressive pseudorheumatoid dysplasia: a rare childhood disease"
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Symptoms are present typically between ages three and six years.
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or through radiography with characteristic skeletal features.
336:"Progressive pseudorheumatoid dysplasia: MedlinePlus Genetics"
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370:, Seattle (WA): University of Washington, Seattle,
18:Spondyloepiphyseal dysplasia tarda progressive art
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80:Stiffness in the joints of the fingers and knees
51:Wnt1-inducible signalling protein 3 (WISP3) gene
228:NORD (National Organization for Rare Disorders)
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84:Symptoms that may develop over time include:
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364:"Progressive Pseudorheumatoid Dysplasia"
224:"Progressive pseudorheumatoid dysplasia"
197:PPD has no severe effect on life span.
31:Progressive pseudorheumatoid disyplasia
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103:PPD is diagnosed by molecular
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27:Bone and cartilage disorder
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281:Rheumatology International
413:10.1186/s12969-018-0272-7
293:10.1007/s00296-018-4170-6
256:rarediseases.info.nih.gov
88:permanently bent fingers
74:Abnormal walking pattern
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400:Pediatric Rheumatology
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60:autosomal recessive
172:. You can help by
128:. You can help by
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343:. Retrieved
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35:stiff joints
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62:pattern.
454:Categories
381:2022-09-07
345:2022-09-07
261:2022-09-07
234:2022-09-07
210:References
422:1546-0096
406:(1): 55.
301:1437-160X
193:Prognosis
149:Treatment
99:Diagnosis
440:30200995
376:26610319
317:53528751
309:30327864
94:hip pain
66:Symptoms
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