325:
302:
224:
199:
36:
31:
331:
230:
1573:, there appears to be a reduction in sigma-1 receptor expression. It has been suggested that targeting the sigma-1 receptor along with other receptors could increase neuron survival and function in neurodegenerative disease. The activation of autophagy has also been suggested as a downstream mechanism linked to sigma-1 receptor activation.
3888:
1561:
that the virus needs for its own replication. This along with the observed beneficial effects of sigma-1 receptor agonist and SSRI fluvoxamine in patients with SARS-COV-2 infection has led to the hypothesis that the sigma-1 receptor could be a target for the treatment of SARS-COV-2.
1593:. Strangely, the mice demonstrated no overt phenotype. As expected, however, they did lack locomotor response to the σ ligand (+)-SKF-10,047 and displayed reduced response to formalin induced pain. Speculation has focused on the ability of other receptors in the σ family (
62:
1374:
was proposed; σ (from the first letter of SKF-10,047). The opioid classification was eventually dropped however resulting from it not possessing the canonical opioid G-protein coupled receptor structure and the receptor was later referred to as simply the
3769:
Grosse
Maestrup E, Wiese C, Schepmann D, Hiller A, Fischer S, Scheunemann M, et al. (May 2009). "Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability".
3459:
Brimson JM, Safrany ST, Qassam H, Tencomnao T (August 2018). "Dipentylammonium Binds to the Sigma-1 Receptor and
Protects Against Glutamate Toxicity, Attenuates Dopamine Toxicity and Potentiates Neurite Outgrowth in Various Cultured Cell Lines".
2868:
Brimson JM, Safrany ST, Qassam H, Tencomnao T (August 2018). "Dipentylammonium Binds to the Sigma-1 Receptor and
Protects Against Glutamate Toxicity, Attenuates Dopamine Toxicity and Potentiates Neurite Outgrowth in Various Cultured Cell Lines".
3560:
Katnik C, Garcia A, Behensky AA, Yasny IE, Shuster AM, Seredenin SB, et al. (February 2014). "Treatment with afobazole at delayed time points following ischemic stroke improves long-term functional and histological outcomes".
338:
237:
3904:"An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones"
1279:
expressed in many different tissue types. It is particularly concentrated in certain regions of the central nervous system. It has been implicated in several phenomena, including cardiovascular function,
3734:
Zampieri D, Grazia Mamolo M, Laurini E, Zanette C, Florio C, Collina S, et al. (January 2009). "Substituted benzooxazol-2(3H)-one derivatives with preference for the sigma1 binding site".
3886:, Buschman HH, "Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain", published 23 May 2007, assigned to Esteve Pharmaceuticals SA
2363:
Cobos EJ, del Pozo E, Baeyens JM (August 2007). "Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells".
2336:
Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE (June 1976). "The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog".
3805:
Schläger T, Schepmann D, Würthwein EU, Wünsch B (March 2008). "Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure".
1435:. It shows no homology to other mammalian proteins but strikingly shares 30% sequence identity and 69% similarity with the ERG2 gene product of yeast, which is a C8-C7 sterol
3596:
Oberdorf C, Schepmann D, Vela JM, Diaz JL, Holenz J, Wünsch B (October 2008). "Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiropyrans]".
3324:
Langa F, Codony X, Tovar V, Lavado A, Giménez E, Cozar P, et al. (October 2003). "Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice".
3278:
Prasanth MI, Malar DS, Tencomnao T, Brimson JM (May 2021). "The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of
Alzheimer's".
3840:
Berardi F, Loiodice F, Fracchiolla G, Colabufo NA, Perrone R, Tortorella V (May 2003). "Synthesis of chiral 1--4-methylpiperidines and their biological evaluation at σ
5292:
4952:
2403:"Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction"
2443:
Brimson JM, Brimson S, Chomchoei C, Tencomnao T (October 2020). "Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain".
3231:"Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy"
4463:
850:
831:
160:
2036:
1483:
receptor antagonists showing GTP-sensitive high-affinity binding; there is also, however, some evidence against a G-protein coupled hypothesis. The σ
4058:
2545:
Moebius FF, Striessnig J, Glossmann H (March 1997). "The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis".
2193:
Zhang H, Cuevas J (June 2005). "sigma
Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons".
4166:
1550:
5551:
5105:
5060:
4672:
3367:
Li X, Hu Z, Liu L, Xie Y, Zhan Y, Zi X, et al. (June 2015). "A SIGMAR1 splice-site mutation causes distal hereditary motor neuropathy".
2641:
Monassier L, Bousquet P (February 2002). "Sigma receptors: from discovery to highlights of their implications in the cardiovascular system".
1968:
1950:
1419:
agonists often follow a bell-shaped dose-response curve. Thus care should be taken when designing experiments and choosing doses of ligands.
5656:
5571:
4997:
2770:"Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP"
5661:
5586:
5536:
5207:
4942:
4920:
4895:
4885:
4730:
4012:
5282:
5232:
5174:
5169:
5496:
5491:
5486:
5481:
5262:
5075:
4845:
1841:
1774:
1166:
1173:
5511:
5506:
5501:
5392:
5387:
5267:
4972:
4870:
4865:
4850:
4785:
4780:
4527:
4101:
5476:
4967:
4456:
4111:
3953:"The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction"
3412:"The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction"
5461:
5456:
4221:
4116:
4106:
4024:
1621:
1545:
is a broad homeostatic, metabolic, cytoplasmic quality control, and metabolic process affecting many functions in the cell. σ
3669:-configuration enantiomers of methylphenylpiracetam are more active positive allosteric modulators of Sigma-1 receptor than
1933:
5706:
4051:
1362:(SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands
59:
2076:"Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene"
4390:
4187:
3182:"Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial"
1912:
4449:
1565:
There has been much interest in the sigma-1 receptor and its role in age-related neurodegenerative diseases such as
324:
4149:
4144:
1868:
affinity but either lack subtype selectivity or have high affinity at other binding sites, thus being more or less
4552:
4154:
4044:
2733:
Hong W, Werling LL (November 2000). "Evidence that the sigma(1) receptor is not directly coupled to G proteins".
1937:
1916:
1468:
301:
131:, ALS16, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R, DSMA2, sigma non-opioid intracellular receptor 1
4592:
2293:
Hayashi T, Su TP (2004). "Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders".
1518:
receptors have been shown to appear in galactoceramide enriched domains at the endoplasmic reticulum of mature
1339:
895:
2914:"Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation"
1475:
receptors have been linked circumstantially to a wide variety of signal transduction pathways. Links between σ
1569:. During healthy ageing, the density of sigma-1 receptors has been to increase. However, in diseases such as
1514:
where they may be involved in preventing endoplasmic reticulum stress in neurodegenerative diseases. Also, σ
876:
5686:
1988:"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival"
223:
198:
140:
337:
236:
5377:
2123:
Weissman AD, Su TP, Hedreen JC, London ED (October 1988). "Sigma receptors in post-mortem human brains".
3505:"Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression"
330:
229:
4318:
4214:
4209:
4075:
1358:
receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of
3883:
5322:
5030:
4323:
127:
4359:
4328:
4204:
4006:
1145:
1141:
1131:
1127:
1123:
1119:
1115:
1086:
1082:
1078:
1074:
1070:
1050:
1046:
1042:
1032:
1028:
1024:
1020:
975:
971:
967:
963:
959:
148:
1296:, and cancer. Much is known about the binding affinity of hundreds of synthetic compounds to the σ
4367:
4338:
4333:
2150:
Guitart X, Codony X, Monroy X (July 2004). "Sigma receptors: biology and therapeutic potential".
1399:), as well as various structurally and pharmacologically distinct psychoactive chemicals such as
3180:
Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, et al. (December 2020).
2486:
Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, et al. (July 1996).
1149:
1100:
1096:
1016:
1001:
997:
993:
989:
985:
5531:
5332:
5040:
4582:
4382:
4289:
4284:
1590:
1570:
1566:
1335:
4937:
4301:
4121:
4067:
3631:
Vavers E, Zvejniece L, Veinberg G, Svalbe B, Domracheva I, Vilskersts R, et al. (2015).
1815:
1731:
1511:
1504:
1304:
1276:
1246:
168:
4002:
4760:
4345:
4274:
4171:
4139:
3516:
3503:
Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, et al. (June 2020).
3136:
2925:
2597:
2499:
2249:
2238:"The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator"
2074:
Prasad PD, Li HW, Fei YJ, Ganapathy ME, Fujita T, Plumley LH, et al. (February 1998).
1359:
1331:
212:
4253:
4248:
4243:
2236:
Fontanilla D, Johannessen M, Hajipour AR, Cozzi NV, Jackson MB, Ruoho AE (February 2009).
8:
4296:
4279:
4258:
4199:
4030:
4018:
3229:
Brimson JM, Prasanth MI, Malar DS, Brimson S, Thitilertdecha P, Tencomnao T (June 2021).
1779:
1-benzyl-6′-methoxy-6′,7′-dihydrospiropyran]: putative antagonist, selective against 5-HT
1558:
1408:
1319:
1285:
1242:
3520:
3140:
2929:
2768:
Lupardus PJ, Wilke RA, Aydar E, Palmer CP, Chen Y, Ruoho AE, et al. (August 2000).
2601:
2503:
2253:
2092:
2075:
5595:
4622:
4596:
4475:
4372:
3977:
3952:
3928:
3903:
3711:
3686:
3659:
3632:
3537:
3504:
3485:
3436:
3411:
3392:
3349:
3303:
3255:
3230:
3206:
3181:
3157:
3124:
3100:
3075:
3051:
3026:
3002:
2977:
2976:
Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, et al. (November 2021).
2894:
2794:
2769:
2710:
2685:
2666:
2618:
2581:
2468:
2318:
2270:
2237:
2218:
2175:
2105:
2017:
1846:
3--4-piperidyl]methyl]-1,3-benzoxazol-2-one: very high affinity and subtype selectivity
1727:
1713:
172:
3123:
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al. (July 2020).
2948:
2913:
2746:
2558:
2488:"Purification, molecular cloning, and expression of the mammalian sigma1-binding site"
765:
760:
755:
750:
745:
740:
735:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
618:
613:
608:
4161:
3982:
3968:
3933:
3865:
3822:
3787:
3751:
3716:
3613:
3578:
3542:
3477:
3441:
3427:
3384:
3341:
3337:
3307:
3295:
3260:
3211:
3162:
3105:
3056:
3007:
2953:
2886:
2850:
2845:
2818:
2799:
2785:
2750:
2715:
2701:
2658:
2654:
2623:
2562:
2527:
2522:
2487:
2472:
2460:
2422:
2380:
2376:
2345:
2310:
2306:
2275:
2210:
2167:
2132:
2097:
2056:
2009:
1250:
120:
52:
3396:
3353:
2670:
2322:
2179:
2109:
2021:
152:
5164:
5130:
4627:
4607:
4428:
4313:
4084:
3972:
3964:
3923:
3915:
3857:
3814:
3779:
3743:
3706:
3698:
3654:
3644:
3605:
3570:
3532:
3524:
3489:
3469:
3431:
3423:
3376:
3333:
3287:
3250:
3242:
3201:
3193:
3152:
3144:
3095:
3087:
3046:
3038:
2997:
2989:
2943:
2933:
2898:
2878:
2840:
2830:
2789:
2781:
2742:
2705:
2697:
2650:
2613:
2605:
2554:
2517:
2507:
2452:
2414:
2372:
2302:
2265:
2257:
2222:
2202:
2159:
2087:
2048:
1999:
1889:
1708:
1519:
1293:
417:
348:
292:
247:
3687:"Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity"
3291:
3246:
3042:
2456:
35:
5421:
5202:
5110:
4710:
4700:
4235:
4131:
3919:
3747:
3380:
1675:
1371:
392:
176:
1973:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1955:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1463:
receptor. Chief among these are modulation of Ca release, modulation of cardiac
30:
5561:
5556:
5002:
4770:
4720:
4602:
4472:
4418:
3649:
3528:
3091:
2993:
2918:
Proceedings of the
National Academy of Sciences of the United States of America
2823:
Proceedings of the
National Academy of Sciences of the United States of America
2492:
Proceedings of the
National Academy of Sciences of the United States of America
2004:
1987:
1586:
1487:
receptor has been shown to appear in a complex with voltage gated K channels (K
1238:
493:
3818:
3783:
3574:
3473:
3148:
2978:"Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes"
2882:
2686:"Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor"
2163:
5700:
5446:
5222:
4992:
4745:
4705:
2418:
1685:
1538:
1380:
1281:
595:
4441:
3197:
2938:
2580:
Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC (April 2016).
2512:
2261:
2206:
553:
431:
5636:
5621:
5601:
5576:
5012:
4905:
4755:
4647:
4642:
4562:
4537:
4093:
3986:
3937:
3869:
3826:
3791:
3755:
3720:
3617:
3582:
3546:
3481:
3445:
3388:
3345:
3299:
3264:
3215:
3166:
3125:"A SARS-CoV-2 protein interaction map reveals targets for drug repurposing"
3109:
3060:
3011:
2957:
2890:
2854:
2835:
2803:
2754:
2719:
2662:
2627:
2464:
2426:
2384:
2314:
2279:
2214:
2171:
2052:
2013:
1742:
1655:
1459:
A variety of specific physiological functions have been attributed to the σ
1412:
1384:
1327:
1323:
1254:
410:
189:
2566:
2531:
2136:
2101:
2060:
2039:
and functional expression of the human type 1 sigma receptor (hSigmaR1)".
1876:. Furthermore, there is a wide range of agents with an at least moderate σ
1447:
receptor indicates three hydrophobic regions. A crystal structure of the σ
1213:
1208:
5671:
5651:
5641:
5606:
5566:
5466:
5397:
5362:
5357:
5347:
5179:
5115:
5070:
5065:
4900:
4860:
4775:
4765:
4740:
4657:
4612:
4577:
4036:
2349:
1873:
1719:
1665:
1554:
1400:
1396:
1392:
1315:
940:
921:
2609:
5666:
5611:
5546:
5541:
5441:
5372:
5352:
5317:
5312:
5307:
5277:
5227:
5184:
5149:
5100:
5095:
5055:
5022:
5017:
5007:
4987:
4982:
4915:
4890:
4715:
4662:
4652:
4617:
4586:
4572:
4547:
4542:
4522:
4517:
2035:
Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V (December 1996). "
1869:
1764:
1759:
1754:
1723:
1700:
1680:
1670:
1440:
1432:
1367:
1312:
309:
206:
156:
3861:
3702:
3609:
1471:. The reasons for these effects are not well understood, even though σ
97:
93:
89:
85:
81:
5646:
5631:
5616:
5591:
5521:
5436:
5416:
5367:
5302:
5297:
5212:
5080:
4977:
4957:
4930:
4910:
4835:
4735:
4725:
4695:
4637:
4632:
4512:
4507:
1833:
1737:
1695:
1660:
1542:
1436:
795:
376:
363:
275:
262:
164:
2402:
1705:
Dipentylamine and its hydrochloride salt (dipentylammonium chloride)
1553:
to inhibit autophagosome formation as a process competing with the
5626:
5581:
5471:
5431:
5426:
5342:
5189:
5050:
4682:
4677:
4667:
3768:
3733:
3027:"SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance"
1613:
1363:
1197:
3839:
2235:
1601:, with similar binding properties) to compensate for the lack of σ
5272:
5252:
5247:
5154:
5090:
4855:
4830:
4825:
4820:
4815:
4810:
4805:
4750:
4567:
4532:
1690:
1650:
1464:
1404:
1289:
907:
862:
780:
776:
3804:
3685:
Wang Y, Guo L, Jiang HF, Zheng LT, Zhang A, Zhen XC (May 2016).
3076:"Biological Functions of Autophagy Genes: A Disease Perspective"
2442:
1636:
receptor and possess high binding selectivity over the subtype σ
144:
5257:
5242:
5159:
5120:
5085:
4962:
4880:
4875:
4840:
4800:
4502:
4308:
1802:
1181:
817:
5217:
5144:
4795:
4497:
3630:
3458:
3277:
2867:
2485:
1530:
receptors are intracellular signal transduction amplifiers.
5194:
4687:
4400:
4395:
4192:
3228:
1852:
1'-benzyl-6-methoxy-1-phenyl-spiropyrazole-4,4'-piperidine]
1769:
1265:
3633:"Novel positive allosteric modulators of sigma-1 receptor"
3179:
2544:
2335:
3595:
3559:
2819:"Regulating ankyrin dynamics: Roles of sigma-1 receptors"
2579:
2338:
The Journal of Pharmacology and Experimental Therapeutics
2195:
The Journal of Pharmacology and Experimental Therapeutics
2125:
The Journal of Pharmacology and Experimental Therapeutics
2975:
2767:
1589:
were created in 2003 to study the effects of endogenous
400:
4553:
3950:
3409:
2122:
1479:
receptors and G-proteins have been suggested such as σ
3502:
3323:
2034:
5195:
4688:
3122:
1322:
have been found to activate the receptor. Especially
565:
2362:
2073:
1379:
receptor. It was found to have affinity for the (+)-
1311:
receptor has yet to be conclusively identified, but
5378:
2684:Brimson JM, Brown CA, Safrany ST (September 2011).
2683:
2149:
2041:
Biochemical and Biophysical Research Communications
751:
G protein-coupled opioid receptor signaling pathway
1929:
1927:
1925:
1908:
1906:
1904:
1632:The following ligands have high affinity for the σ
1522:. The wide scope and effect of ligand binding on σ
1443:biosynthetic pathway. Hydropathy analysis of the σ
1431:receptor is an integral membrane protein with 223
5323:
5031:
3951:Sambo DO, Lebowitz JJ, Khoshbouei H (June 2018).
3684:
3410:Sambo DO, Lebowitz JJ, Khoshbouei H (June 2018).
2640:
347:
246:
5698:
4083:
3319:
3317:
3025:Yang H, Shen H, Li J, Guo LW (September 2019).
2438:
2436:
2396:
2394:
1922:
1901:
5333:
5041:
1934:GRCm38: Ensembl release 89: ENSMUSG00000036078
4471:
4457:
4052:
3901:
3073:
3024:
1403:(which permanently blocks this receptor) and
3895:
3833:
3798:
3762:
3727:
3678:
3589:
3314:
2905:
2810:
2761:
2726:
2634:
2538:
2433:
2391:
2186:
3882:
2732:
2479:
2192:
2143:
1913:GRCh38: Ensembl release 89: ENSG00000147955
766:cell death in response to hydrogen peroxide
4464:
4450:
4066:
4059:
4045:
3902:Lee IT, Chen S, Schetz JA (January 2008).
3366:
2329:
2116:
2067:
2028:
609:G protein-coupled opioid receptor activity
4005:at the U.S. National Library of Medicine
3976:
3927:
3710:
3658:
3648:
3536:
3435:
3254:
3205:
3156:
3099:
3050:
3001:
2947:
2937:
2911:
2844:
2834:
2816:
2793:
2709:
2617:
2521:
2511:
2400:
2292:
2269:
2091:
2003:
1985:
3624:
1608:
1526:receptors has led some to believe that σ
4593:Dehydroepiandrosterone sulfate (DHEA-S)
4558:Tooltip Calcitonin gene-related peptide
3736:European Journal of Medicinal Chemistry
2643:Fundamental & Clinical Pharmacology
5699:
1979:
1880:involvement in their binding profile.
1503:receptors apparently co-localize with
741:regulation of neuron apoptotic process
4445:
4040:
3848:, and sterol Δ8–Δ7 isomerase sites".
3280:Expert Opinion on Therapeutic Targets
3235:Expert Opinion on Therapeutic Targets
2971:
2969:
2967:
2445:Expert Opinion on Therapeutic Targets
1622:distal spinal muscular atrophy type 2
1549:R is targeted by the nsp6 protein of
675:integral component of plasma membrane
352:
313:
308:
251:
210:
205:
3807:Bioorganic & Medicinal Chemistry
3772:Bioorganic & Medicinal Chemistry
3326:The European Journal of Neuroscience
3074:Levine B, Kroemer G (January 2019).
5383:Tooltip 3,4,5-Trimethoxyamphetamine
3691:CNS Neuroscience & Therapeutics
2093:10.1046/j.1471-4159.1998.70020443.x
1499:receptors are auxiliary subunits. σ
13:
2964:
2547:Trends in Pharmacological Sciences
1986:Hayashi T, Su TP (November 2007).
1370:, respectively) and a new type of
1349:
14:
5718:
5557:Chlorphenamine (chlorpheniramine)
5328:Tooltip N,N-Diisopropyltryptamine
5036:Tooltip N,N-Diisopropyltryptamine
3996:
2912:Hayashi T, Su TP (October 2004).
2817:Hayashi T, Su TP (January 2001).
2582:"Crystal structure of the human σ
2401:Su TP, Hayashi T (October 2003).
1467:contractility, and inhibition of
3969:10.1016/j.pharmthera.2018.01.009
3908:European Journal of Pharmacology
3428:10.1016/j.pharmthera.2018.01.009
3338:10.1046/j.1460-9568.2003.02950.x
2786:10.1111/j.1469-7793.2000.00527.x
2735:European Journal of Pharmacology
2702:10.1111/j.1476-5381.2011.01417.x
2655:10.1046/j.1472-8206.2002.00063.x
2377:10.1111/j.1471-4159.2007.04533.x
2307:10.2165/00023210-200418050-00001
1576:
1495:1.5), leading to the idea that σ
1451:receptor was published in 2016.
1415:. Pharmacological studies with σ
336:
329:
323:
300:
235:
228:
222:
197:
34:
29:
4309:Calcitonin gene-related peptide
3957:Pharmacology & Therapeutics
3944:
3876:
3553:
3496:
3452:
3416:Pharmacology & Therapeutics
3403:
3360:
3271:
3222:
3173:
3116:
3067:
3018:
2861:
2690:British Journal of Pharmacology
2677:
2573:
2356:
2286:
2229:
1726:, which lacks affinity for the
1620:gene have been associated with
5338:Tooltip N,N-Dipropyltryptamine
5046:Tooltip N,N-Dipropyltryptamine
4746:Pentoxyverine (carbetapentane)
3850:Journal of Medicinal Chemistry
3598:Journal of Medicinal Chemistry
1961:
1943:
1809:Positive allosteric modulators
1799:adrenergic, and NMDA receptors
1340:dehydroepiandrosterone sulfate
710:integral component of membrane
645:endoplasmic reticulum membrane
554:More reference expression data
1:
5687:Receptor/signaling modulators
4583:Dehydroepiandrosterone (DHEA)
3292:10.1080/14728222.2021.1939681
3247:10.1080/14728222.2021.1952987
3043:10.1080/15548627.2019.1586248
2747:10.1016/S0014-2999(00)00774-3
2559:10.1016/s0165-6147(96)01037-1
2457:10.1080/14728222.2020.1805435
1895:
1864:Agents exist that have high σ
321:
220:
4268:Other neuropeptide receptors
3920:10.1016/j.ejphar.2007.09.020
3748:10.1016/j.ejmech.2008.03.011
3381:10.1212/WNL.0000000000001680
1454:
1422:
7:
5707:Genes on human chromosome 9
4771:Racemethorphan (methorphan)
4017:human gene location in the
3673:-configuration enantiomers.
2407:Current Medicinal Chemistry
1883:
1541:formation and maturation.
1261:receptor is encoded by the
619:signaling receptor activity
446:stromal cell of endometrium
10:
5723:
4076:G protein-coupled receptor
4029:human gene details in the
3650:10.1186/2193-1801-4-S1-P51
3529:10.1038/s41598-020-65849-6
3092:10.1016/j.cell.2018.09.048
2994:10.1016/j.cell.2021.10.017
2005:10.1016/j.cell.2007.08.036
1627:
746:nervous system development
5680:
5406:
5129:
4482:
4411:
4391:Atrial natriuretic factor
4381:
4358:
4267:
4234:
4188:Atrial natriuretic factor
4180:
4130:
4092:
4074:
3819:10.1016/j.bmc.2007.12.045
3784:10.1016/j.bmc.2009.03.060
3575:10.1016/j.nbd.2013.10.011
3474:10.1007/s12640-018-9883-5
3149:10.1038/s41586-020-2286-9
2883:10.1007/s12640-018-9883-5
2774:The Journal of Physiology
2365:Journal of Neurochemistry
2164:10.1007/s00213-004-1920-9
2080:Journal of Neurochemistry
1969:"Mouse PubMed Reference:"
1951:"Human PubMed Reference:"
1537:R has been implicated in
1212:
1207:
1203:
1196:
1180:
1161:
1138:
1114:
1093:
1069:
1062:
1039:
1015:
982:
958:
951:
938:
934:
919:
915:
906:
893:
889:
874:
870:
861:
848:
844:
829:
825:
816:
801:
794:
790:
774:
756:protein homotrimerization
614:identical protein binding
594:
590:
578:
573:
564:
551:
500:
491:
438:
429:
399:
391:
387:
370:
357:
320:
299:
290:
286:
269:
256:
219:
196:
187:
183:
138:
135:
125:
118:
113:
78:
73:
56:
51:
46:
42:
28:
23:
4648:Fabomotizole (afobazole)
4623:Dimethyltryptamine (DMT)
4360:Type I cytokine receptor
4007:Medical Subject Headings
2419:10.2174/0929867033456783
1469:voltage gated K channels
5612:Mepyramine (pyrilamine)
5293:3-Methoxydextrallorphan
4953:3-Methoxydextrallorphan
4776:Racemorphan (morphanol)
3198:10.1001/jama.2020.22760
2939:10.1073/pnas.0402890101
2513:10.1073/pnas.93.15.8072
2262:10.1126/science.1166127
2207:10.1124/jpet.105.084152
1872:/multifunctional, like
1859:)-4-methyl-1-piperidine
1174:Chr 4: 41.74 – 41.76 Mb
1167:Chr 9: 34.63 – 34.64 Mb
5667:Tiospirone (BMY-13859)
5607:Gevotroline (WY-47384)
5532:18-Methoxycoronaridine
5519:Allosteric modulators:
5278:Panamesine (EMD-57455)
5228:Siramesine (Lu 28-179)
5165:Ditolylguanidine (DTG)
4928:Allosteric modulators:
4891:Panamesine (EMD-57455)
4836:BMY-14802 (BMS-181100)
4628:Ditolylguanidine (DTG)
4608:Dextromethorphan (DXM)
4383:Enzyme-linked receptor
4068:Neuropeptide receptors
3462:Neurotoxicity Research
2871:Neurotoxicity Research
2836:10.1073/pnas.021413698
2053:10.1006/bbrc.1996.1842
1342:(DHEA-S) bind to the σ
1336:N,N-dimethyltryptamine
690:nuclear outer membrane
685:nuclear inner membrane
536:superior frontal gyrus
4938:Methylphenylpiracetam
4513:Alazocine (SKF-10047)
2988:(24): 5950–5969.e22.
1816:Methylphenylpiracetam
1609:Clinical significance
1512:endoplasmic reticulum
1277:transmembrane protein
1247:endoplasmic reticulum
705:endoplasmic reticulum
635:postsynaptic membrane
540:primary visual cortex
450:right coronary artery
4761:Pregnenolone sulfate
4573:Cutamesine (SA-4503)
1409:neuroactive steroids
1360:N-allylnormetazocine
1332:pregnenolone sulfate
1320:neuroactive steroids
1249:(ER) that modulates
720:postsynaptic density
478:left coronary artery
466:right adrenal cortex
315:Chromosome 4 (mouse)
213:Chromosome 9 (human)
74:List of PDB id codes
47:Available structures
4911:Rimcazole (BW-234U)
4031:UCSC Genome Browser
4019:UCSC Genome Browser
3521:2020NatSR..10.9251B
3141:2020Natur.583..459G
2930:2004PNAS..10114949H
2924:(41): 14949–14954.
2610:10.1038/nature17391
2602:2016Natur.532..527S
2504:1996PNAS...93.8072H
2254:2009Sci...323..934F
1571:Alzheimer's disease
1567:Alzheimer's disease
1286:clinical depression
1257:. In humans, the σ
761:signal transduction
715:cytoplasmic vesicle
470:canal of the cervix
462:right adrenal gland
442:right lobe of liver
177:SIGMAR1 - orthologs
4668:Igmesine (JO-1784)
4597:prasterone sulfate
3509:Scientific Reports
2152:Psychopharmacology
1714:Dimethyltryptamine
896:ENSMUSG00000036078
729:Biological process
628:Cellular component
602:Molecular function
504:left lobe of liver
474:left adrenal gland
5694:
5693:
5529:Unknown/unsorted:
5290:Unknown/unsorted:
5025:
4950:Unknown/unsorted:
4613:Dextrorphan (DXO)
4439:
4438:
4354:
4353:
4319:GPCR neuropeptide
4230:
4229:
4085:Hormone receptors
3862:10.1021/jm021014d
3856:(11): 2117–2124.
3778:(10): 3630–3641.
3703:10.1111/cns.12502
3610:10.1021/jm8007739
3604:(20): 6531–6537.
3375:(24): 2430–2437.
3192:(22): 2292–2300.
3135:(7816): 459–468.
2596:(7600): 527–530.
2498:(15): 8072–8077.
2451:(10): 1009–1028.
2413:(20): 2073–2080.
2248:(5916): 934–937.
1722:(the "unnatural"
1510:receptors on the
1288:, the effects of
1251:calcium signaling
1243:chaperone protein
1223:
1222:
1219:
1218:
1192:
1191:
1157:
1156:
1108:
1107:
1058:
1057:
1009:
1008:
947:
946:
928:
927:
902:
901:
883:
882:
857:
856:
838:
837:
786:
785:
586:
585:
582:
581:
560:
559:
547:
546:
485:
484:
458:left uterine tube
383:
382:
282:
281:
109:
108:
105:
104:
57:Ortholog search:
16:Chaperone protein
5714:
5384:
5380:
5339:
5335:
5329:
5325:
5198:(midomafetamine)
5197:
5047:
5043:
5037:
5033:
5023:
4691:(midomafetamine)
4690:
4559:
4555:
4466:
4459:
4452:
4443:
4442:
4236:Opioid receptors
4090:
4089:
4081:
4080:
4061:
4054:
4047:
4038:
4037:
4003:sigma-1+receptor
3991:
3990:
3980:
3948:
3942:
3941:
3931:
3914:(2–3): 123–136.
3899:
3893:
3892:
3891:
3887:
3880:
3874:
3873:
3837:
3831:
3830:
3813:(6): 2992–3001.
3802:
3796:
3795:
3766:
3760:
3759:
3731:
3725:
3724:
3714:
3682:
3676:
3675:
3662:
3652:
3628:
3622:
3621:
3593:
3587:
3586:
3557:
3551:
3550:
3540:
3500:
3494:
3493:
3456:
3450:
3449:
3439:
3407:
3401:
3400:
3364:
3358:
3357:
3332:(8): 2188–2196.
3321:
3312:
3311:
3275:
3269:
3268:
3258:
3226:
3220:
3219:
3209:
3177:
3171:
3170:
3160:
3120:
3114:
3113:
3103:
3071:
3065:
3064:
3054:
3037:(9): 1539–1557.
3022:
3016:
3015:
3005:
2973:
2962:
2961:
2951:
2941:
2909:
2903:
2902:
2865:
2859:
2858:
2848:
2838:
2814:
2808:
2807:
2797:
2765:
2759:
2758:
2730:
2724:
2723:
2713:
2681:
2675:
2674:
2638:
2632:
2631:
2621:
2577:
2571:
2570:
2542:
2536:
2535:
2525:
2515:
2483:
2477:
2476:
2440:
2431:
2430:
2398:
2389:
2388:
2360:
2354:
2353:
2333:
2327:
2326:
2290:
2284:
2283:
2273:
2233:
2227:
2226:
2201:(3): 1387–1396.
2190:
2184:
2183:
2147:
2141:
2140:
2120:
2114:
2113:
2095:
2071:
2065:
2064:
2032:
2026:
2025:
2007:
1983:
1977:
1976:
1965:
1959:
1958:
1947:
1941:
1931:
1920:
1910:
1890:Sigma-2 receptor
1709:Dextromethorphan
1520:oligodendrocytes
1294:bipolar disorder
1227:sigma-1 receptor
1205:
1204:
1176:
1169:
1152:
1112:
1111:
1103:
1067:
1066:
1063:RefSeq (protein)
1053:
1013:
1012:
1004:
956:
955:
932:
931:
913:
912:
887:
886:
868:
867:
842:
841:
823:
822:
792:
791:
700:nuclear envelope
592:
591:
571:
570:
556:
496:
494:Top expressed in
489:
488:
434:
432:Top expressed in
427:
426:
406:
405:
389:
388:
379:
366:
355:
340:
333:
327:
316:
304:
288:
287:
278:
265:
254:
239:
232:
226:
215:
201:
185:
184:
179:
130:
123:
100:
71:
70:
65:
44:
43:
38:
33:
21:
20:
5722:
5721:
5717:
5716:
5715:
5713:
5712:
5711:
5697:
5696:
5695:
5690:
5676:
5596:St. John's wort
5422:Ethylketazocine
5402:
5382:
5337:
5327:
5203:Methamphetamine
5134:
5125:
5111:Trifluoperazine
5045:
5035:
4711:Methylphenidate
4701:Methamphetamine
4557:
4487:
4478:
4470:
4440:
4435:
4407:
4377:
4350:
4263:
4226:
4205:Cholecystokinin
4176:
4126:
4070:
4065:
3999:
3994:
3949:
3945:
3900:
3896:
3889:
3881:
3877:
3847:
3843:
3838:
3834:
3803:
3799:
3767:
3763:
3732:
3728:
3683:
3679:
3643:(Suppl 1): 51.
3629:
3625:
3594:
3590:
3558:
3554:
3501:
3497:
3457:
3453:
3408:
3404:
3365:
3361:
3322:
3315:
3276:
3272:
3227:
3223:
3178:
3174:
3121:
3117:
3072:
3068:
3023:
3019:
2974:
2965:
2910:
2906:
2866:
2862:
2815:
2811:
2766:
2762:
2731:
2727:
2696:(2b): 772–780.
2682:
2678:
2639:
2635:
2585:
2578:
2574:
2543:
2539:
2484:
2480:
2441:
2434:
2399:
2392:
2361:
2357:
2334:
2330:
2291:
2287:
2234:
2230:
2191:
2187:
2148:
2144:
2121:
2117:
2072:
2068:
2033:
2029:
1984:
1980:
1967:
1966:
1962:
1949:
1948:
1944:
1932:
1923:
1911:
1902:
1898:
1886:
1879:
1867:
1862:
1798:
1794:
1790:
1786:
1782:
1676:Methamphetamine
1639:
1635:
1630:
1611:
1604:
1600:
1584:
1579:
1548:
1536:
1529:
1525:
1517:
1508:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1462:
1457:
1450:
1446:
1430:
1427:The mammalian σ
1425:
1418:
1378:
1372:opioid receptor
1357:
1352:
1350:Characteristics
1345:
1310:
1299:
1274:
1260:
1241:subtypes, is a
1234:
1214:View/Edit Mouse
1209:View/Edit Human
1172:
1165:
1162:Location (UCSC)
1148:
1144:
1140:
1134:
1130:
1126:
1122:
1118:
1099:
1095:
1089:
1085:
1081:
1077:
1073:
1049:
1045:
1041:
1035:
1031:
1027:
1023:
1019:
1000:
996:
992:
988:
984:
978:
974:
970:
966:
962:
877:ENSG00000147955
770:
736:lipid transport
724:
665:plasma membrane
640:cell projection
623:
552:
543:
538:
534:
530:
526:
522:
518:
514:
510:
506:
492:
481:
476:
472:
468:
464:
460:
456:
452:
448:
444:
430:
374:
361:
353:
343:
342:
341:
334:
314:
291:Gene location (
273:
260:
252:
242:
241:
240:
233:
211:
188:Gene location (
139:
126:
119:
80:
58:
17:
12:
11:
5:
5720:
5710:
5709:
5692:
5691:
5681:
5678:
5677:
5675:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5639:
5634:
5629:
5624:
5619:
5614:
5609:
5604:
5599:
5589:
5584:
5579:
5574:
5569:
5564:
5562:Chlorpromazine
5559:
5554:
5549:
5544:
5539:
5534:
5525:
5524:
5515:
5514:
5509:
5504:
5499:
5494:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5450:
5449:
5444:
5439:
5434:
5429:
5424:
5419:
5410:
5408:
5404:
5403:
5401:
5400:
5395:
5390:
5385:
5375:
5370:
5365:
5360:
5355:
5350:
5345:
5340:
5330:
5320:
5315:
5310:
5305:
5300:
5295:
5286:
5285:
5280:
5275:
5270:
5265:
5260:
5255:
5250:
5245:
5236:
5235:
5230:
5225:
5220:
5215:
5210:
5205:
5200:
5192:
5187:
5182:
5177:
5172:
5167:
5162:
5157:
5152:
5147:
5138:
5136:
5132:
5127:
5126:
5124:
5123:
5118:
5113:
5108:
5103:
5098:
5093:
5088:
5083:
5078:
5073:
5068:
5063:
5058:
5053:
5048:
5038:
5028:
5020:
5015:
5010:
5005:
5003:Chlorpromazine
5000:
4995:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4946:
4945:
4940:
4924:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4888:
4883:
4878:
4873:
4868:
4863:
4858:
4856:E-52862 (S1RA)
4853:
4848:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4808:
4803:
4798:
4789:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4721:Neuropeptide Y
4718:
4713:
4708:
4703:
4698:
4693:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4603:Dextrallorphan
4600:
4590:
4580:
4575:
4570:
4565:
4560:
4550:
4545:
4540:
4535:
4530:
4525:
4520:
4515:
4510:
4505:
4500:
4491:
4489:
4485:
4480:
4479:
4473:Sigma receptor
4469:
4468:
4461:
4454:
4446:
4437:
4436:
4434:
4433:
4432:
4431:
4426:
4415:
4413:
4409:
4408:
4406:
4405:
4404:
4403:
4398:
4387:
4385:
4379:
4378:
4376:
4375:
4370:
4364:
4362:
4356:
4355:
4352:
4351:
4349:
4348:
4343:
4342:
4341:
4336:
4331:
4326:
4316:
4311:
4306:
4305:
4304:
4294:
4293:
4292:
4287:
4277:
4271:
4269:
4265:
4264:
4262:
4261:
4256:
4251:
4246:
4240:
4238:
4232:
4231:
4228:
4227:
4225:
4224:
4219:
4218:
4217:
4212:
4202:
4197:
4196:
4195:
4184:
4182:
4178:
4177:
4175:
4174:
4169:
4164:
4159:
4158:
4157:
4152:
4147:
4136:
4134:
4128:
4127:
4125:
4124:
4119:
4114:
4109:
4104:
4098:
4096:
4087:
4078:
4072:
4071:
4064:
4063:
4056:
4049:
4041:
4035:
4034:
4022:
4010:
3998:
3997:External links
3995:
3993:
3992:
3943:
3894:
3875:
3845:
3841:
3832:
3797:
3761:
3742:(1): 124–130.
3726:
3697:(5): 368–377.
3677:
3623:
3588:
3552:
3495:
3468:(2): 263–272.
3451:
3402:
3359:
3313:
3286:(5): 401–414.
3270:
3241:(6): 435–449.
3221:
3172:
3115:
3086:(1–2): 11–42.
3066:
3017:
2963:
2904:
2877:(2): 263–272.
2860:
2829:(2): 491–496.
2809:
2780:(3): 527–539.
2760:
2741:(2): 117–125.
2725:
2676:
2633:
2583:
2572:
2537:
2478:
2432:
2390:
2371:(3): 812–825.
2355:
2344:(3): 517–532.
2328:
2301:(5): 269–284.
2285:
2228:
2185:
2158:(3): 301–319.
2142:
2115:
2086:(2): 443–451.
2066:
2047:(2): 553–558.
2027:
1998:(3): 596–610.
1978:
1960:
1942:
1921:
1899:
1897:
1894:
1893:
1892:
1885:
1882:
1877:
1865:
1861:
1860:
1853:
1850:
1847:
1844:
1839:
1836:
1831:
1825:Uncategorized:
1822:
1821:
1818:
1806:
1805:
1800:
1796:
1792:
1788:
1784:
1780:
1777:
1772:
1767:
1762:
1757:
1746:
1745:
1740:
1735:
1716:
1711:
1706:
1703:
1698:
1693:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1642:
1637:
1633:
1629:
1626:
1610:
1607:
1602:
1598:
1582:
1578:
1575:
1546:
1534:
1527:
1523:
1515:
1506:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1460:
1456:
1453:
1448:
1444:
1428:
1424:
1421:
1416:
1376:
1355:
1351:
1348:
1343:
1313:tryptaminergic
1308:
1303:An endogenous
1297:
1275:receptor is a
1272:
1258:
1239:sigma receptor
1237:), one of two
1232:
1221:
1220:
1217:
1216:
1211:
1201:
1200:
1194:
1193:
1190:
1189:
1187:
1185:
1178:
1177:
1170:
1163:
1159:
1158:
1155:
1154:
1136:
1135:
1109:
1106:
1105:
1091:
1090:
1064:
1060:
1059:
1056:
1055:
1037:
1036:
1010:
1007:
1006:
980:
979:
953:
949:
948:
945:
944:
936:
935:
929:
926:
925:
917:
916:
910:
904:
903:
900:
899:
891:
890:
884:
881:
880:
872:
871:
865:
859:
858:
855:
854:
846:
845:
839:
836:
835:
827:
826:
820:
814:
813:
808:
803:
799:
798:
788:
787:
784:
783:
772:
771:
769:
768:
763:
758:
753:
748:
743:
738:
732:
730:
726:
725:
723:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
631:
629:
625:
624:
622:
621:
616:
611:
605:
603:
599:
598:
588:
587:
584:
583:
580:
579:
576:
575:
568:
562:
561:
558:
557:
549:
548:
545:
544:
542:
541:
537:
533:
529:
525:
521:
517:
513:
509:
508:tail of embryo
505:
501:
498:
497:
486:
483:
482:
480:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
436:
435:
423:
422:
414:
403:
397:
396:
393:RNA expression
385:
384:
381:
380:
372:
368:
367:
359:
356:
351:
345:
344:
335:
328:
322:
318:
317:
312:
306:
305:
297:
296:
284:
283:
280:
279:
271:
267:
266:
258:
255:
250:
244:
243:
234:
227:
221:
217:
216:
209:
203:
202:
194:
193:
181:
180:
137:
133:
132:
124:
116:
115:
111:
110:
107:
106:
103:
102:
76:
75:
67:
66:
55:
49:
48:
40:
39:
26:
25:
15:
9:
6:
4:
3:
2:
5719:
5708:
5705:
5704:
5702:
5689:
5688:
5685:
5679:
5673:
5670:
5668:
5665:
5663:
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5623:
5620:
5618:
5615:
5613:
5610:
5608:
5605:
5603:
5600:
5597:
5593:
5590:
5588:
5585:
5583:
5580:
5578:
5575:
5573:
5570:
5568:
5565:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5527:
5526:
5523:
5520:
5517:
5516:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5452:
5451:
5448:
5447:Tenocyclidine
5445:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5418:
5415:
5412:
5411:
5409:
5405:
5399:
5396:
5394:
5391:
5389:
5386:
5381:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5359:
5356:
5354:
5351:
5349:
5346:
5344:
5341:
5336:
5331:
5326:
5321:
5319:
5316:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5294:
5291:
5288:
5287:
5284:
5281:
5279:
5276:
5274:
5271:
5269:
5266:
5264:
5261:
5259:
5256:
5254:
5251:
5249:
5246:
5244:
5241:
5238:
5237:
5234:
5231:
5229:
5226:
5224:
5223:Phencyclidine
5221:
5219:
5216:
5214:
5211:
5209:
5206:
5204:
5201:
5199:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5140:
5139:
5137:
5135:
5128:
5122:
5119:
5117:
5114:
5112:
5109:
5107:
5104:
5102:
5099:
5097:
5094:
5092:
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5044:
5039:
5034:
5029:
5027:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4993:Amitriptyline
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4948:
4947:
4944:
4941:
4939:
4936:
4932:
4929:
4926:
4925:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4797:
4794:
4791:
4790:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4706:Methoxetamine
4704:
4702:
4699:
4697:
4694:
4692:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4598:
4594:
4591:
4588:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4556:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4499:
4496:
4493:
4492:
4490:
4488:
4481:
4477:
4474:
4467:
4462:
4460:
4455:
4453:
4448:
4447:
4444:
4430:
4427:
4425:
4422:
4421:
4420:
4417:
4416:
4414:
4410:
4402:
4399:
4397:
4394:
4393:
4392:
4389:
4388:
4386:
4384:
4380:
4374:
4371:
4369:
4366:
4365:
4363:
4361:
4357:
4347:
4344:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4321:
4320:
4317:
4315:
4312:
4310:
4307:
4303:
4300:
4299:
4298:
4295:
4291:
4288:
4286:
4283:
4282:
4281:
4278:
4276:
4273:
4272:
4270:
4266:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4241:
4239:
4237:
4233:
4223:
4220:
4216:
4213:
4211:
4208:
4207:
4206:
4203:
4201:
4198:
4194:
4191:
4190:
4189:
4186:
4185:
4183:
4179:
4173:
4170:
4168:
4165:
4163:
4160:
4156:
4153:
4151:
4148:
4146:
4143:
4142:
4141:
4138:
4137:
4135:
4133:
4129:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4099:
4097:
4095:
4091:
4088:
4086:
4082:
4079:
4077:
4073:
4069:
4062:
4057:
4055:
4050:
4048:
4043:
4042:
4039:
4032:
4028:
4027:
4023:
4020:
4016:
4015:
4011:
4008:
4004:
4001:
4000:
3988:
3984:
3979:
3974:
3970:
3966:
3962:
3958:
3954:
3947:
3939:
3935:
3930:
3925:
3921:
3917:
3913:
3909:
3905:
3898:
3885:
3879:
3871:
3867:
3863:
3859:
3855:
3851:
3836:
3828:
3824:
3820:
3816:
3812:
3808:
3801:
3793:
3789:
3785:
3781:
3777:
3773:
3765:
3757:
3753:
3749:
3745:
3741:
3737:
3730:
3722:
3718:
3713:
3708:
3704:
3700:
3696:
3692:
3688:
3681:
3674:
3672:
3668:
3661:
3656:
3651:
3646:
3642:
3638:
3634:
3627:
3619:
3615:
3611:
3607:
3603:
3599:
3592:
3584:
3580:
3576:
3572:
3568:
3564:
3563:Neurobiol Dis
3556:
3548:
3544:
3539:
3534:
3530:
3526:
3522:
3518:
3514:
3510:
3506:
3499:
3491:
3487:
3483:
3479:
3475:
3471:
3467:
3463:
3455:
3447:
3443:
3438:
3433:
3429:
3425:
3421:
3417:
3413:
3406:
3398:
3394:
3390:
3386:
3382:
3378:
3374:
3370:
3363:
3355:
3351:
3347:
3343:
3339:
3335:
3331:
3327:
3320:
3318:
3309:
3305:
3301:
3297:
3293:
3289:
3285:
3281:
3274:
3266:
3262:
3257:
3252:
3248:
3244:
3240:
3236:
3232:
3225:
3217:
3213:
3208:
3203:
3199:
3195:
3191:
3187:
3183:
3176:
3168:
3164:
3159:
3154:
3150:
3146:
3142:
3138:
3134:
3130:
3126:
3119:
3111:
3107:
3102:
3097:
3093:
3089:
3085:
3081:
3077:
3070:
3062:
3058:
3053:
3048:
3044:
3040:
3036:
3032:
3028:
3021:
3013:
3009:
3004:
2999:
2995:
2991:
2987:
2983:
2979:
2972:
2970:
2968:
2959:
2955:
2950:
2945:
2940:
2935:
2931:
2927:
2923:
2919:
2915:
2908:
2900:
2896:
2892:
2888:
2884:
2880:
2876:
2872:
2864:
2856:
2852:
2847:
2842:
2837:
2832:
2828:
2824:
2820:
2813:
2805:
2801:
2796:
2791:
2787:
2783:
2779:
2775:
2771:
2764:
2756:
2752:
2748:
2744:
2740:
2736:
2729:
2721:
2717:
2712:
2707:
2703:
2699:
2695:
2691:
2687:
2680:
2672:
2668:
2664:
2660:
2656:
2652:
2648:
2644:
2637:
2629:
2625:
2620:
2615:
2611:
2607:
2603:
2599:
2595:
2591:
2587:
2576:
2568:
2564:
2560:
2556:
2552:
2548:
2541:
2533:
2529:
2524:
2519:
2514:
2509:
2505:
2501:
2497:
2493:
2489:
2482:
2474:
2470:
2466:
2462:
2458:
2454:
2450:
2446:
2439:
2437:
2428:
2424:
2420:
2416:
2412:
2408:
2404:
2397:
2395:
2386:
2382:
2378:
2374:
2370:
2366:
2359:
2351:
2347:
2343:
2339:
2332:
2324:
2320:
2316:
2312:
2308:
2304:
2300:
2296:
2289:
2281:
2277:
2272:
2267:
2263:
2259:
2255:
2251:
2247:
2243:
2239:
2232:
2224:
2220:
2216:
2212:
2208:
2204:
2200:
2196:
2189:
2181:
2177:
2173:
2169:
2165:
2161:
2157:
2153:
2146:
2138:
2134:
2130:
2126:
2119:
2111:
2107:
2103:
2099:
2094:
2089:
2085:
2081:
2077:
2070:
2062:
2058:
2054:
2050:
2046:
2042:
2038:
2031:
2023:
2019:
2015:
2011:
2006:
2001:
1997:
1993:
1989:
1982:
1974:
1970:
1964:
1956:
1952:
1946:
1939:
1935:
1930:
1928:
1926:
1918:
1914:
1909:
1907:
1905:
1900:
1891:
1888:
1887:
1881:
1875:
1871:
1858:
1854:
1851:
1848:
1845:
1843:
1840:
1837:
1835:
1832:
1829:
1828:
1827:
1826:
1819:
1817:
1814:
1813:
1812:
1810:
1804:
1801:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1752:
1751:
1750:
1744:
1741:
1739:
1736:
1733:
1729:
1725:
1721:
1717:
1715:
1712:
1710:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1686:Amitriptyline
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1648:
1647:
1646:
1641:
1625:
1623:
1619:
1615:
1606:
1596:
1592:
1588:
1587:knockout mice
1577:Knockout mice
1574:
1572:
1568:
1563:
1560:
1559:endomembranes
1557:for cellular
1556:
1552:
1544:
1540:
1539:autophagosome
1531:
1521:
1513:
1509:
1470:
1466:
1452:
1442:
1438:
1434:
1420:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1385:benzomorphans
1382:
1381:stereoisomers
1373:
1369:
1365:
1361:
1347:
1341:
1337:
1333:
1329:
1325:
1321:
1317:
1314:
1306:
1301:
1295:
1291:
1287:
1283:
1282:schizophrenia
1278:
1269:
1267:
1264:
1256:
1252:
1248:
1244:
1240:
1236:
1228:
1215:
1210:
1206:
1202:
1199:
1195:
1188:
1186:
1183:
1179:
1175:
1171:
1168:
1164:
1160:
1153:
1151:
1147:
1143:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1110:
1104:
1102:
1098:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1065:
1061:
1054:
1052:
1048:
1044:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1011:
1005:
1003:
999:
995:
991:
987:
981:
977:
973:
969:
965:
961:
957:
954:
952:RefSeq (mRNA)
950:
943:
942:
937:
933:
930:
924:
923:
918:
914:
911:
909:
905:
898:
897:
892:
888:
885:
879:
878:
873:
869:
866:
864:
860:
853:
852:
847:
843:
840:
834:
833:
828:
824:
821:
819:
815:
812:
809:
807:
804:
800:
797:
793:
789:
782:
778:
773:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
733:
731:
728:
727:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
680:cell junction
678:
676:
673:
671:
668:
666:
663:
661:
660:lipid droplet
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
632:
630:
627:
626:
620:
617:
615:
612:
610:
607:
606:
604:
601:
600:
597:
596:Gene ontology
593:
589:
577:
572:
569:
567:
563:
555:
550:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
502:
499:
495:
490:
487:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
440:
437:
433:
428:
425:
424:
421:
419:
415:
413:
412:
408:
407:
404:
402:
398:
394:
390:
386:
378:
373:
369:
365:
360:
350:
346:
339:
332:
326:
319:
311:
307:
303:
298:
294:
289:
285:
277:
272:
268:
264:
259:
249:
245:
238:
231:
225:
218:
214:
208:
204:
200:
195:
191:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
134:
129:
122:
117:
112:
101:
99:
95:
91:
87:
83:
77:
72:
69:
68:
64:
61:
54:
50:
45:
41:
37:
32:
27:
22:
19:
5683:
5682:
5637:Promethazine
5622:Perphenazine
5602:Fluphenazine
5577:Clocapramine
5552:Carvotroline
5528:
5518:
5454:Antagonists:
5453:
5413:
5289:
5240:Antagonists:
5239:
5141:
5013:Clomipramine
4949:
4934:
4927:
4906:Progesterone
4793:Antagonists:
4792:
4756:Pregnenolone
4643:Escitalopram
4563:Cloperastine
4538:Blarcamesine
4494:
4483:
4423:
4122:Somatostatin
4094:Hypothalamic
4025:
4013:
3960:
3956:
3946:
3911:
3907:
3897:
3878:
3853:
3849:
3835:
3810:
3806:
3800:
3775:
3771:
3764:
3739:
3735:
3729:
3694:
3690:
3680:
3670:
3666:
3664:
3640:
3637:SpringerPlus
3636:
3626:
3601:
3597:
3591:
3566:
3562:
3555:
3512:
3508:
3498:
3465:
3461:
3454:
3419:
3415:
3405:
3372:
3368:
3362:
3329:
3325:
3283:
3279:
3273:
3238:
3234:
3224:
3189:
3185:
3175:
3132:
3128:
3118:
3083:
3079:
3069:
3034:
3030:
3020:
2985:
2981:
2921:
2917:
2907:
2874:
2870:
2863:
2826:
2822:
2812:
2777:
2773:
2763:
2738:
2734:
2728:
2693:
2689:
2679:
2646:
2642:
2636:
2593:
2589:
2575:
2553:(3): 67–70.
2550:
2546:
2540:
2495:
2491:
2481:
2448:
2444:
2410:
2406:
2368:
2364:
2358:
2341:
2337:
2331:
2298:
2294:
2288:
2245:
2241:
2231:
2198:
2194:
2188:
2155:
2151:
2145:
2131:(1): 29–33.
2128:
2124:
2118:
2083:
2079:
2069:
2044:
2040:
2030:
1995:
1991:
1981:
1972:
1963:
1954:
1945:
1863:
1856:
1824:
1823:
1808:
1807:
1749:Antagonists:
1748:
1747:
1743:Fabomotizole
1656:Blarcamesine
1644:
1643:
1631:
1617:
1612:
1594:
1580:
1564:
1532:
1458:
1426:
1413:progesterone
1388:
1353:
1328:testosterone
1324:progesterone
1316:trace amines
1302:
1270:
1262:
1255:IP3 receptor
1253:through the
1230:
1226:
1224:
1146:NP_001273534
1142:NP_001273480
1139:
1132:NP_001273471
1128:NP_001273470
1124:NP_001273469
1120:NP_001273468
1116:NP_001273467
1094:
1087:NP_001269138
1083:NP_001269137
1079:NP_001269136
1075:NP_001269135
1071:NP_001269134
1051:NM_001286605
1047:NM_001286551
1043:NM_001286542
1040:
1033:NM_001286541
1029:NM_001286540
1025:NM_001286539
1021:NM_001286538
983:
976:NM_001282209
972:NM_001282208
968:NM_001282207
964:NM_001282206
960:NM_001282205
939:
920:
894:
875:
849:
830:
810:
805:
524:right kidney
416:
409:
136:External IDs
79:
18:
5672:Venlafaxine
5652:Remoxipride
5642:Propranolol
5567:Cinnarizine
5467:Lamotrigine
5363:Pentazocine
5358:Noribogaine
5348:Nemonapride
5180:Haloperidol
5106:Spipethiane
5071:Noribogaine
5066:Nemonapride
5061:KCR-12-83.1
4901:Pentazocine
4861:Haloperidol
4766:Pridopidine
4741:Pentazocine
4658:Fluvoxamine
4578:Cyclazocine
4346:Neurotensin
4275:Angiotensin
4140:Vasopressin
3963:: 152–167.
3569:: 354–364.
3515:(1): 9251.
3422:: 152–167.
1874:haloperidol
1838:Spipethiane
1734:receptors.)
1720:pentazocine
1666:Fluvoxamine
1555:coronavirus
1533:Recently, σ
1433:amino acids
1401:haloperidol
1397:cyclazocine
1393:pentazocine
1383:of several
1326:, but also
655:growth cone
375:41,756,157
362:41,738,493
354:4|4 A5
274:34,637,844
261:34,634,722
114:Identifiers
5657:SL 82.0715
5572:Cinuperone
5547:Caramiphen
5542:Butaclamol
5442:Tapentadol
5373:Safinamide
5353:Nepinalone
5318:Clemastine
5313:5-MeO-DiPT
5308:5-MeO-DALT
5185:Ifenprodil
5150:Arketamine
5101:Selegiline
5096:Safinamide
5056:Imipramine
5018:Clorgiline
5008:Clemastine
4998:Azidopamil
4988:5-MeO-DiPT
4983:5-MeO-DALT
4916:Sertraline
4716:Nepinalone
4663:Ifenprodil
4653:Fluoxetine
4618:Dimemorfan
4587:prasterone
4548:Citalopram
4543:Captodiame
4523:Arketamine
4518:Amantadine
4476:modulators
4297:Tachykinin
4280:Bradykinin
4259:Nociceptin
4200:Calcitonin
3884:EP 1787679
2649:(1): 1–8.
1940:, May 2017
1919:, May 2017
1896:References
1765:Sertraline
1760:D-Deprenyl
1755:Selegiline
1724:enantiomer
1701:Cutamesine
1681:Citalopram
1671:Fluoxetine
1605:receptor.
1551:SARS-CoV-2
1441:ergosterol
1368:ketazocine
1346:receptor.
1338:(DMT) and
1300:receptor.
454:ectocervix
420:(ortholog)
157:HomoloGene
5684:See also:
5662:SR-31747A
5647:Quinidine
5632:Proadifen
5617:Molindone
5592:Hypericin
5587:EMD-59983
5537:BMY-13980
5522:SKF-83959
5437:Naluzotan
5417:Berberine
5414:Agonists:
5368:RS-67,333
5303:4-MeO-PCP
5298:3-MeO-PCE
5213:Opipramol
5208:OPC-14523
5142:Agonists:
5081:RS-67,333
5026:-Deprenyl
4978:4-MeO-PCP
4958:3-MeO-PCP
4943:SOMCL-668
4935:Positive:
4931:Phenytoin
4921:SR-31742A
4896:PD-144418
4886:NPC-16377
4736:Opipramol
4731:OPC-14523
4726:Noscapine
4696:Memantine
4638:Eliprodil
4633:Donepezil
4508:5-MeO-DMT
4495:Agonists:
4373:Prolactin
4132:Pituitary
3369:Neurology
3308:235402107
3031:Autophagy
2586:receptor"
2473:225218231
2295:CNS Drugs
1834:PD 144418
1820:SOMCL-668
1738:Opipramol
1696:L-687,384
1661:Donepezil
1645:Agonists:
1614:Mutations
1585:receptor
1543:Autophagy
1491:1.4 and K
1455:Functions
1437:isomerase
1423:Structure
1307:for the σ
1150:NP_035144
1101:NP_671513
1097:NP_005857
1017:NM_011014
1002:NM_147160
998:NM_147159
994:NM_147158
990:NM_147157
986:NM_005866
796:Orthologs
165:GeneCards
5701:Category
5627:Pimozide
5582:Dezocine
5472:Naloxone
5432:Metaphit
5427:Fourphit
5407:Unsorted
5343:Ibogaine
5283:SAS-0132
5233:UKH-1114
5190:Ketamine
5175:DKR-1051
5170:DKR-1005
5051:Ibogaine
4683:L-687384
4678:Ketamine
4162:Oxytocin
3987:29360540
3938:17961544
3870:12747784
3827:18221879
3792:19394833
3756:18440098
3721:26854125
3618:18816044
3583:24141021
3547:32514120
3482:29589276
3446:29360540
3397:22155027
3389:26078401
3354:85814812
3346:14622179
3300:34110944
3265:34236922
3216:33180097
3167:32353859
3110:30633901
3061:30871407
3012:34741801
2958:15466698
2891:29589276
2855:11149946
2804:10922005
2755:11080517
2720:21486275
2671:27932111
2663:11903506
2628:27042935
2465:32746649
2427:12871086
2385:17419803
2323:72726251
2315:15089113
2280:19213917
2215:15764734
2180:23606712
2172:15197533
2110:22305479
2022:18885068
2014:17981125
1936:–
1915:–
1884:See also
1849:1'-spiro
1811:(PAMs):
1732:κ-opioid
1728:μ-opioid
1395:and (+)-
1364:morphine
1198:Wikidata
775:Sources:
650:membrane
528:yolk sac
512:epiblast
5497:UMB-116
5492:UMB-103
5487:UMB-101
5482:UMB-100
5273:MIN-101
5263:CT-1812
5253:BD-1067
5248:BD-1008
5155:BD-1047
5091:Saffron
5076:RHL-033
4846:Dup-734
4831:BD-1067
4826:BD-1063
4821:BD-1060
4816:BD-1047
4811:BD-1031
4806:BD-1008
4751:PRE-084
4568:Cocaine
4533:BD-1052
4314:Galanin
4026:SIGMAR1
4014:SIGMAR1
3978:5962385
3929:2963108
3712:6492821
3660:4797911
3538:7280195
3517:Bibcode
3490:4378593
3437:5962385
3256:8290373
3207:7662481
3158:7431030
3137:Bibcode
3101:6347410
3052:6693456
3003:8616855
2926:Bibcode
2899:4378593
2795:2270035
2711:3188898
2619:5550834
2598:Bibcode
2567:9133773
2532:8755605
2500:Bibcode
2271:2947205
2250:Bibcode
2242:Science
2223:9704436
2137:2845055
2102:9453537
2061:8954936
2037:Cloning
1938:Ensembl
1917:Ensembl
1842:RHL-033
1775:FTC-146
1691:Cocaine
1651:PRE-084
1628:Ligands
1618:SIGMAR1
1616:in the
1465:myocyte
1439:in the
1405:cocaine
1292:abuse,
1290:cocaine
1263:SIGMAR1
1245:at the
908:UniProt
863:Ensembl
802:Species
781:QuickGO
695:nucleus
670:synapse
395:pattern
169:SIGMAR1
153:1195268
128:SIGMAR1
121:Aliases
24:SIGMAR1
5512:YZ-185
5507:YZ-069
5502:YZ-011
5393:UMB-82
5388:UMB-23
5268:LR-172
5258:CM-156
5243:AC-927
5160:BD1063
5121:YKP10A
5086:RTI-55
4973:4-IPBS
4963:4C-T-2
4881:NE-100
4876:MS-377
4871:LR-172
4866:LR-132
4851:E-5842
4841:CM-156
4801:AC-927
4786:UMB-82
4781:UMB-23
4528:BD-737
4503:4-PPBP
4009:(MeSH)
3985:
3975:
3936:
3926:
3890:
3868:
3825:
3790:
3754:
3719:
3709:
3657:
3616:
3581:
3545:
3535:
3488:
3480:
3444:
3434:
3395:
3387:
3352:
3344:
3306:
3298:
3263:
3253:
3214:
3204:
3165:
3155:
3129:Nature
3108:
3098:
3059:
3049:
3010:
3000:
2956:
2949:522002
2946:
2897:
2889:
2853:
2843:
2802:
2792:
2753:
2718:
2708:
2669:
2661:
2626:
2616:
2590:Nature
2565:
2530:
2520:
2471:
2463:
2425:
2383:
2350:945347
2348:
2321:
2313:
2278:
2268:
2221:
2213:
2178:
2170:
2135:
2108:
2100:
2059:
2020:
2012:
1830:4-IPBS
1803:NE-100
1787:, 5-HT
1783:, 5-HT
1407:, and
1391:, (+)-
1305:ligand
1184:search
1182:PubMed
941:O55242
922:Q99720
818:Entrez
566:BioGPS
532:embryo
520:embryo
253:9p13.3
145:601978
5477:SM-21
5218:PB-28
5145:3-PPP
4968:4-IBP
4796:3-PPP
4498:3-PPP
4419:Sigma
4412:Other
4302:TACR1
4249:Kappa
4244:Delta
4181:Other
3486:S2CID
3393:S2CID
3350:S2CID
3304:S2CID
2895:S2CID
2846:14614
2667:S2CID
2523:38877
2469:S2CID
2319:S2CID
2219:S2CID
2176:S2CID
2106:S2CID
2018:S2CID
1870:dirty
1855:(−)-(
1795:and α
1411:like
1354:The σ
1271:The σ
851:18391
832:10280
811:Mouse
806:Human
777:Amigo
418:Mouse
411:Human
358:Start
293:Mouse
257:Start
190:Human
161:39965
5462:AZ66
5457:AHD1
5398:W-18
5324:DiPT
5196:MDMA
5116:W-18
5032:DiPT
4689:MDMA
4673:IPAB
4554:CGRP
4401:NPR2
4396:NPR1
4193:NPR3
4167:LHCG
4112:LHRH
3983:PMID
3934:PMID
3866:PMID
3823:PMID
3788:PMID
3752:PMID
3717:PMID
3665:The
3614:PMID
3579:PMID
3543:PMID
3478:PMID
3442:PMID
3385:PMID
3342:PMID
3296:PMID
3261:PMID
3212:PMID
3186:JAMA
3163:PMID
3106:PMID
3080:Cell
3057:PMID
3008:PMID
2982:Cell
2954:PMID
2887:PMID
2851:PMID
2800:PMID
2751:PMID
2716:PMID
2659:PMID
2624:PMID
2563:PMID
2528:PMID
2461:PMID
2423:PMID
2381:PMID
2346:PMID
2311:PMID
2276:PMID
2211:PMID
2168:PMID
2133:PMID
2098:PMID
2057:PMID
2010:PMID
1992:Cell
1770:S1RA
1730:and
1718:(+)-
1595:e.g.
1389:e.g.
1366:and
1318:and
1266:gene
1225:The
401:Bgee
349:Band
310:Chr.
248:Band
207:Chr.
141:OMIM
98:6DK1
94:6DK0
90:6DJZ
86:5HK2
82:5HK1
63:RCSB
60:PDBe
5379:TMA
5334:DPT
5042:DPT
4324:B/W
4222:VIP
4172:TSH
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