249:
29:
239:
259:
5628:
269:
657:. The binding sites for substrate and ATP are located in the catalytic cleft between the domains (or lobes). When ATP and substrate bind, the two lobes rotate so that the terminal phosphate group of the ATP and the target amino acid of the substrate move into the correct positions for the catalytic reaction to take place.
494:
and use 2.7.11.1, "non-specific serine/threonine protein kinase". This entry is for any enzyme that phosphorylates proteins while converting ATP to ADP (i.e., ATP:protein phosphotransferases.) 2.7.11.37 "protein kinase" was the former generic placeholder and was split into several entries (including
1309:
Capra, Maria; Nuciforo, Paolo
Giovanni; Confalonieri, Stefano; Quarto, Micaela; Bianchi, Marco; Nebuloni, Manuela; Boldorini, Renzo; Pallotti, Francesco; Viale, Giuseppe; Gishizky, Mikhail L.; Draetta, Giulio F.; Fiore, Pier Paolo Di (15 August 2006). "Frequent Alterations in the Expression of
600:
AKT8. The gene codes for a protein kinase. Human homologs of the AKT8 oncogenic protein were identified in 1987.By 1995 it had been found that Akt kinases function as mitogen-activated kinases downstream from cell surface receptors that activate
1394:
Clark, D. E.; Errington, T. M.; Smith, J. A.; Frierson, H. F.; Weber, M. J.; Lannigan, D. A. (15 April 2005). "The Serine/Threonine
Protein Kinase, p90 Ribosomal S6 Kinase, Is an Important Regulator of Prostate Cancer Cell Proliferation".
2366:
2229:
1470:
2497:
3299:
452:
serine or threonine residues in their substrates, they select specific residues to phosphorylate on the basis of residues that flank the phosphoacceptor site, which together comprise the
3413:
3491:
3776:
387:
482:
that binds to the kinase like a real substrate but lacks the amino acid to be phosphorylated. When the pseudosubstrate is removed, the kinase can perform its normal function.
830:
Nowakowski, J.; Cronin, C. N.; McRee, D. E.; Knuth, M. W.; Nelson, C. G.; Pavletich, N. P.; Rogers, J.; Sang, B. C.; Scheibe, D. N.; Swanson, R. V.; Thompson, D. A. (2002).
777:
1463:
2773:
466:), a kinase is usually not specific to a single substrate, but instead can phosphorylate a whole "substrate family" which share common recognition sequences. While the
458:. Since the consensus sequence residues of a target substrate only make contact with several key amino acids within the catalytic cleft of the kinase (usually through
2796:
699:
respond to extracellular stimuli (mitogens) and regulate various cellular activities, such as gene expression, mitosis, differentiation, and cell survival/apoptosis.
202:
3309:
2579:
2745:
3283:
3484:
3304:
1456:
762:. Limited benefit of serine/threonine kinase inhibitors has been demonstrated in ovarian cancer but studies are ongoing to evaluate their safety and efficacy.
3477:
3424:
3402:
2371:
3684:
1178:
Wang Y, Hofmann TG, Runkel L, Haaf T, Schaller H, Debatin K, Hug H (2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2".
3388:
3220:
1347:"Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature"
5029:
1731:
1479:
221:
1131:"Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue"
5071:
4232:
3535:
928:
Damuni Z, Reed LJ (1988). "Purification and properties of a protamine kinase and a type II casein kinase from bovine kidney mitochondria".
3435:
680:. They are divided into three subfamilies: conventional (or classical), novel, and atypical based on their second messenger requirements.
5180:
3363:
3330:
478:(the subset of genes in the genome that encode kinases) provides for recognition of distinct substrates. Many kinases are inhibited by a
3918:
3805:
2891:
572:
inhibition has become the target for new anti-metastatic cancer drugs as they inhibit the MAPK cascade and reduce cell proliferation.
4193:
3225:
2851:
1967:
1522:
712:
5166:
4985:
4227:
4217:
4212:
2474:
2110:
1915:
1629:
1585:
507:
5268:
5149:
2432:
2287:
1828:
214:
4855:
3724:
2310:
2066:
2061:
1823:
1512:
1082:"A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization"
358:. Protein phosphorylation in particular plays a significant role in a wide range of cellular processes and is a very important
4919:
3894:
3031:
568:
form part of the MAPKK Kinase family and are activated by growth factors. The enzyme functions to stimulate growth of cells.
165:
5175:
2411:
2334:
963:
Baggio B, Pinna LA, Moret V, Siliprandi N (1970). "A simple procedure for the purification of rat liver phosvitin kinase".
789:
5658:
3709:
605:. Three human akt genes exist. All three Akt kinases regulate cell proliferation and Akt2 is particularly important for
4907:
3165:
2454:
5232:
5347:
4164:
4154:
3839:
2735:
2529:
1863:
319:, which have similar side chains. At least 350 of the 500+ human protein kinases are serine/threonine kinases (STK).
3469:
4846:
2876:
1993:
1345:
Ciccone, Marcia A.; Maoz, Asaf; Casabar, Jennifer K.; Machida, Hiroko; Mabuchi, Seiji; Matsuo, Koji (2 July 2016).
693:
5115:
4787:
4149:
4140:
359:
159:
2422:
1624:
1600:
1580:
141:
5503:
4530:
4027:
4018:
3675:
3621:
3449:
3444:
3004:
2822:
2181:
1634:
146:
1433:
3718:
3314:
3202:
3170:
3155:
2387:
2362:
2353:
2215:
1868:
832:"Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography"
2837:
2246:
1495:
805:
372:
226:
134:
5618:
4742:
4560:
4056:
2507:
5604:
5591:
5578:
5565:
5552:
5539:
5526:
5488:
4732:
4727:
4722:
4712:
4707:
4702:
4692:
4487:
4262:
3858:
2713:
809:
602:
436:
Serine/threonine kinases play a role in the regulation of cell proliferation, programmed cell death (
69:
5653:
5498:
5452:
5395:
4955:
4946:
4897:
3663:
3508:
2900:
2881:
2812:
2666:
2546:
2469:
2056:
1559:
1541:
1437:
727:
704:
685:
662:
636:
618:
577:
550:
531:
491:
394:
283:
162:
52:
86:
5400:
5255:
4678:
2758:
2262:
1972:
1942:
1927:
1890:
1448:
3212:
2985:
2895:
1550:
398:
5421:
5340:
3954:
3066:
3021:
2723:
2708:
2644:
2624:
2522:
2343:
2154:
1922:
410:
5493:
4521:
2980:
2975:
2855:
2718:
2698:
2607:
1746:
1261:
1237:
884:
735:
122:
873:"A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains"
8:
5457:
4630:
3243:
3235:
3016:
2683:
2619:
2583:
2325:
2198:
766:
511:
406:
98:
64:
3521:
888:
57:
5648:
5390:
5132:
5086:
3106:
3044:
2995:
2730:
2557:
1696:
1371:
1346:
1000:"Protamine kinase from rainbow trout testis. Partial purification and characterization"
905:
872:
471:
454:
1191:
1155:
1130:
1106:
1081:
1057:
1040:
1016:
999:
848:
831:
177:
4392:
4101:
3499:
3121:
3111:
3101:
3026:
3010:
2969:
2955:
2950:
2688:
2651:
1619:
1575:
1412:
1376:
1327:
1195:
1160:
1111:
1062:
1021:
980:
976:
945:
941:
910:
853:
153:
34:
631:
is a serine/threonine kinase that can phosphorylate itself, and also Tube and Toll.
5436:
5431:
5405:
5333:
4130:
4121:
4051:
4042:
3988:
3979:
3636:
3454:
3116:
3096:
3038:
2934:
2832:
2817:
2763:
2661:
2656:
2515:
1590:
1568:
1564:
1404:
1366:
1358:
1319:
1187:
1150:
1142:
1101:
1093:
1052:
1011:
972:
937:
900:
892:
843:
670:
644:
467:
1408:
1362:
1323:
495:
2.7.11.1) in 2005. 2.7.11.70 "protamine kinase" was merged into 2.7.11.1 in 2004.
5483:
5467:
5380:
4811:
3882:
3877:
3872:
3377:
3367:
3189:
3160:
2786:
2693:
2678:
2305:
2037:
2032:
1998:
1895:
1647:
770:
540:
479:
449:
421:
355:
301:
1129:
NF; Lützelberger, M; Weigmann, H; Klingenhoff, A; Shenoy, S; Käufer, NF (1997).
498:
2.7.11.- is the generic level where all serine/threonine kinases should sit in.
181:
5632:
5521:
5462:
3345:
3184:
3091:
3083:
2960:
2923:
2009:
896:
414:
297:
197:
5642:
5426:
5385:
3867:
2614:
2027:
1900:
272:
172:
3935:
2088:
1285:
1146:
38:
5375:
4806:
3631:
2703:
2673:
2602:
2044:
1882:
1416:
1380:
1331:
1199:
914:
857:
799:
795:
740:
was in fact, the first Ser/Thr protein kinase to be discovered (in 1959 by
248:
1164:
1115:
1066:
1041:"Action of adenosine 3',5'-monophosphate-dependent histone kinase in vivo"
1025:
984:
949:
5599:
5534:
5370:
5012:
4644:
4584:
4467:
4387:
4111:
3269:
3259:
2860:
2597:
2538:
1947:
1517:
741:
730:
707:
688:
665:
654:
639:
335:
28:
1213:
1097:
621:
580:
553:
534:
286:
110:
5100:
3574:
3071:
2914:
2827:
2592:
2542:
2537:
2137:
1932:
1609:
719:
650:
597:
562:
558:
490:
Many serine/threonine protein kinases do not have their own individual
463:
459:
323:
309:
5573:
5547:
4061:
3350:
3263:
2800:
2566:
2459:
2401:
1614:
1532:
758:
Serine/threonine kinase (STK) expression is altered in many types of
437:
347:
316:
262:
252:
238:
5627:
4417:
4312:
4307:
4302:
3197:
2777:
1443:
593:
365:
The chemical reaction performed by these enzymes can be written as
305:
3777:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
268:
258:
5076:
5054:
5049:
5039:
5034:
4836:
4831:
4826:
4821:
4816:
4801:
4796:
4447:
4412:
3651:
3646:
3641:
3300:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
3148:
3133:
2749:
2479:
2203:
2049:
1478:
1128:
677:
606:
506:
Types include those acting directly as membrane-bound receptors (
402:
351:
129:
1214:"ENZYME - 2.7.11.1 non-specific serine/threonine protein kinase"
780:
as they inhibit the MAPK cascade and reduce cell proliferation.
5586:
5356:
5306:
5301:
5296:
5291:
5286:
5281:
5276:
5227:
5222:
5217:
5212:
5207:
5190:
5185:
5059:
5044:
4995:
4990:
4975:
4970:
4965:
4960:
4934:
4929:
4924:
4912:
4890:
4885:
4777:
4752:
4427:
4252:
4247:
4242:
4237:
4222:
4066:
4003:
3998:
3993:
3969:
3795:
3790:
3764:
3759:
3754:
3744:
3739:
3729:
3569:
3500:
3126:
2561:
2484:
2272:
2267:
1977:
1308:
759:
475:
343:
339:
331:
312:
293:
290:
242:
209:
105:
93:
81:
5560:
5202:
5195:
5105:
5002:
4902:
4880:
4875:
4870:
4865:
4860:
4772:
4767:
4762:
4757:
4747:
4717:
4697:
4574:
4569:
4550:
4545:
4535:
4511:
4506:
4501:
4477:
4472:
4462:
4457:
4452:
4442:
4422:
4407:
4402:
4397:
4377:
4372:
4362:
4357:
4352:
4347:
4342:
4332:
4327:
4322:
4317:
4297:
4292:
4287:
4282:
4277:
4272:
4257:
4207:
4202:
4096:
4091:
4086:
4081:
4076:
4071:
4032:
3964:
3959:
3908:
3903:
3829:
3824:
3819:
3785:
3579:
3564:
3559:
3554:
3549:
3544:
3143:
3138:
2990:
2498:
deficiencies of intracellular signaling peptides and proteins
2282:
2277:
2239:
2224:
2191:
2186:
2147:
2142:
2130:
2125:
2120:
2115:
2103:
2081:
2076:
2071:
1848:
1843:
1838:
1833:
1793:
1788:
1726:
1721:
1716:
1711:
1686:
1681:
1676:
1671:
1666:
1661:
1656:
626:
610:
569:
5095:
5022:
5017:
5007:
4980:
4737:
4687:
4668:
4663:
4658:
4653:
4608:
4603:
4598:
4593:
4540:
4496:
4437:
4432:
4382:
4367:
4337:
4267:
4183:
4178:
4173:
4106:
4008:
3949:
3944:
3848:
3814:
3699:
3694:
3689:
3658:
3626:
3614:
3609:
3604:
3594:
3589:
3054:
3049:
2945:
2940:
2639:
2634:
2629:
2464:
2449:
2234:
2174:
2169:
2164:
2159:
2098:
2093:
1937:
1910:
1905:
1818:
1813:
1808:
1803:
1798:
1775:
1770:
1765:
1760:
1755:
1706:
1701:
1691:
1393:
117:
5325:
962:
829:
676:
is actually a family of protein kinases consisting of ~10
5064:
3599:
3584:
1344:
586:
5254:
5616:
3310:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
1177:
649:
consists of two domains, a small domain with several
375:
3315:
CDP-diacylglycerol—choline O-phosphatidyltransferase
440:), cell differentiation, and embryonic development.
3305:
CDP-diacylglycerol—serine O-phosphatidyltransferase
609:actions in cells. A major target of Akt kinases is
2372:Sh2 domain-containing protein tyrosine phosphatase
653:structures and a larger domain containing several
381:
474:, the sequence variation that is observed in the
5640:
1079:
802:). It can be related to proteins of this class.
545:was discovered in 1954 by Burnett and Kennedy.
5341:
3536:Non-specific serine/threonine protein kinases
3485:
2523:
1480:Intracellular signaling peptides and proteins
1464:
776:Raf inhibition has become the target for new
510:) and intracellular kinases participating in
426:ATP:protein phosphotransferase (non-specific)
1310:Serine/Threonine Kinases in Human Cancers".
870:
769:(RSK) is in involved in development of some
3331:N-acetylglucosamine-1-phosphate transferase
3221:UTP—glucose-1-phosphate uridylyltransferase
997:
5348:
5334:
3919:Goodpasture-antigen-binding protein kinase
3492:
3478:
2530:
2516:
2367:Receptor-like protein tyrosine phosphatase
1471:
1457:
927:
871:Modi, V; Dunbrack, RL (24 December 2019).
27:
4632:Serine/threonine-specific protein kinases
3806:(isocitrate dehydrogenase (NADP+)) kinase
3523:Serine/threonine-specific protein kinases
3505:Serine/threonine-specific protein kinases
3425:serine/threonine-specific protein kinases
3403:serine/threonine-specific protein kinases
3226:Galactose-1-phosphate uridylyltransferase
1968:Cyclin-dependent kinase inhibitor protein
1436:at the U.S. National Library of Medicine
1370:
1154:
1105:
1056:
1038:
1015:
904:
847:
713:Ca2+/calmodulin-dependent protein kinases
5167:Receptor protein serine/threonine kinase
2475:Phosphatidylethanolamine binding protein
2111:Interleukin-1 receptor associated kinase
1523:Ca2+/calmodulin-dependent protein kinase
1444:KinCore (Kinase Conformational Resource)
765:Serine/threonine protein kinase p90-kDa
753:
508:Receptor protein serine/threonine kinase
267:
257:
247:
237:
5150:Low-density-lipoprotein receptor kinase
1351:Expert Opinion on Investigational Drugs
5641:
2230:Focal adhesion protein-tyrosine kinase
1513:Intracellular calcium-sensing proteins
5329:
5253:
4629:
3895:Fas-activated serine/threonine kinase
3520:
3473:
2511:
1452:
1302:
798:, a protein without enzyme activity (
592:The v-akt gene was identified as the
5267:
5176:Bone morphogenetic protein receptors
790:Protein serine/threonine phosphatase
3710:Dephospho-(reductase kinase) kinase
864:
448:While serine/threonine kinases all
382:{\displaystyle \rightleftharpoons }
13:
4165:G-protein coupled receptor kinases
2455:Signal transducing adaptor protein
1630:3',5'-cyclic-GMP phosphodiesterase
1586:3',5'-cyclic-AMP phosphodiesterase
718:are primarily regulated by the Ca/
338:, that transfer phosphates to the
14:
5670:
4155:Beta adrenergic receptor kinase-2
3840:(tyrosine 3-monooxygenase) kinase
2736:Glucose-1,6-bisphosphate synthase
2450:Activating transcription factor 6
1864:G protein-coupled receptor kinase
1427:
694:Mitogen-activated protein kinases
5626:
4847:Mitogen-activated protein kinase
2877:Ribose-phosphate diphosphokinase
1994:Phosphoinositide phospholipase C
1434:protein-serine-threonine+kinases
585:Protein Kinase B, also known as
539:CK2, also known by the misnomer
514:. Of the latter, types include:
22:Protein-serine/threonine kinases
5233:Anti-MĂĽllerian hormone receptor
5116:(acetyl-CoA carboxylase) kinase
4788:(RNA-polymerase)-subunit kinase
4150:Beta adrenergic receptor kinase
4141:Beta adrenergic receptor kinase
1387:
1338:
1278:
1254:
1230:
1206:
1080:Takeuchi M, Yanagida M (1993).
808:, responsible for the disorder
360:post-translational modification
328:serine/threonine protein kinase
280:serine/threonine protein kinase
16:Class of protein kinase enzymes
4856:Extracellular signal-regulated
2433:GTP-binding protein regulators
2423:GTP-binding protein regulators
1171:
1122:
1073:
1032:
991:
956:
921:
823:
443:
376:
1:
4920:P38 mitogen-activated protein
4019:cGMP-dependent protein kinase
3980:cAMP-dependent protein kinase
3676:Pyruvate dehydrogenase kinase
3622:Ataxia telangiectasia mutated
3450:Protein-histidine tele-kinase
3445:Protein-histidine pros-kinase
3324:Glycosyl-1-phosphotransferase
2182:Rho-associated protein kinase
1409:10.1158/0008-5472.CAN-04-3151
1363:10.1080/13543784.2016.1181748
1324:10.1158/0008-5472.CAN-05-3489
1192:10.1016/S0167-4781(00)00308-0
1058:10.1016/S0021-9258(18)63626-9
1017:10.1016/S0021-9258(18)63408-8
849:10.1016/S0969-2126(02)00907-3
816:
792:, enzyme for reverse process.
485:
3719:AMP-activated protein kinase
3156:RNA-dependent RNA polymerase
2388:Dual-specificity phosphatase
2363:protein tyrosine phosphatase
1869:AMP-activated protein kinase
977:10.1016/0005-2744(70)90261-5
942:10.1016/0003-9861(88)90408-0
778:anti-metastatic cancer drugs
7:
5355:
4634:(EC 2.7.11.21-EC 2.7.11.30)
3063:RNA-directed DNA polymerase
2931:DNA-directed DNA polymerase
2412:apoptosis signaling pathway
998:Jergil B, Dixon GH (1970).
806:ATM serine/threonine kinase
783:
431:
10:
5675:
5659:Enzymes of known structure
4561:Elongation factor 2 kinase
3525:(EC 2.7.11.1-EC 2.7.11.20)
3416:: protein-dual-specificity
897:10.1038/s41598-019-56499-4
611:glycogen synthase kinase-3
5512:
5504:Michaelis–Menten kinetics
5476:
5445:
5414:
5363:
5263:
5249:
5165:
5148:
5131:
5114:
5085:
4956:MAP kinase kinase kinases
4945:
4845:
4786:
4677:
4643:
4639:
4625:
4583:
4559:
4520:
4488:Myosin light-chain kinase
4486:
4194:Ca2+/calmodulin-dependent
4192:
4163:
4139:
4120:
4041:
4017:
3978:
3934:
3917:
3893:
3859:Myosin-heavy-chain kinase
3857:
3838:
3804:
3775:
3708:
3674:
3534:
3530:
3516:
3434:
3412:
3387:
3362:
3343:
3323:
3292:
3282:
3252:
3234:
3211:
3183:
3082:
2922:
2913:
2890:
2850:
2795:
2772:
2744:
2578:
2554:
2493:
2442:
2421:
2400:
2380:
2352:
2333:
2323:
2298:
2256:Serine/threonine/tyrosine
2255:
2214:
2017:
2007:
1986:
1960:
1881:
1859:
1742:
1643:
1599:
1549:
1540:
1531:
1505:
1486:
603:phosphoinositide 3-kinase
354:. This process is called
220:
208:
196:
191:
187:
171:
152:
140:
128:
116:
104:
92:
80:
75:
63:
51:
46:
26:
21:
5396:Diffusion-limited enzyme
5256:Dual-specificity kinases
3393:protein-serine/threonine
3293:Phosphatidyltransferases
2882:Thiamine diphosphokinase
2470:Olfactory marker protein
2057:Glycogen synthase kinase
1560:Heterotrimeric G protein
1438:Medical Subject Headings
501:
424:of this enzyme class is
4679:Cyclin-dependent kinase
2263:Dual-specificity kinase
1973:Cyclin-dependent kinase
1262:"KEGG ENZYME: 2.7.1.70"
1238:"KEGG ENZYME: 2.7.1.37"
3213:Nucleotidyltransferase
2896:nucleotidyltransferase
2823:Nucleoside-diphosphate
1180:Biochim. Biophys. Acta
965:Biochim. Biophys. Acta
930:Arch. Biochem. Biophys
389:ADP + a phosphoprotein
383:
275:
265:
255:
245:
5489:Eadie–Hofstee diagram
5422:Allosteric regulation
3067:Reverse transcriptase
2344:Protein phosphatase 2
2155:p21-activated kinases
1147:10.1093/nar/25.5.1028
810:ataxia–telangiectasia
754:Clinical significance
715:or CaM kinases (CAMK)
384:
330:describes a class of
271:
261:
251:
241:
5499:Lineweaver–Burk plot
4522:Phosphorylase kinase
2856:diphosphotransferase
2838:Thiamine-diphosphate
2545:-containing groups (
1747:G beta-gamma complex
736:Phosphorylase kinase
470:of these kinases is
373:
33:Human Aurora Kinase
3438:: protein-histidine
3356:; protein acceptor)
3244:mRNA capping enzyme
3236:Guanylyltransferase
2326:protein phosphatase
2199:Ribosomal s6 kinase
1098:10.1091/mbc.4.3.247
889:2019NatSR...919790M
767:ribosomal S6 kinase
512:Signal transduction
397:of this enzyme are
310:amino-acid residues
5458:Enzyme superfamily
5391:Enzyme promiscuity
5133:Tropomyosin kinase
5087:Tau-protein kinase
2714:Phosphoinositide 3
2558:phosphotransferase
1496:MAP kinase pathway
1039:Langan TA (1969).
877:Scientific Reports
455:consensus sequence
405:, whereas its two
379:
296:, in particular a
276:
266:
256:
246:
5614:
5613:
5323:
5322:
5319:
5318:
5315:
5314:
5245:
5244:
5241:
5240:
4621:
4620:
4617:
4616:
4102:Protein kinase N1
4057:Protein kinase Cζ
3467:
3466:
3463:
3462:
3339:
3338:
3278:
3277:
3179:
3178:
3092:Template-directed
2846:
2845:
2813:Phosphomevalonate
2505:
2504:
2460:I-kappa B protein
2396:
2395:
2319:
2318:
1956:
1955:
1877:
1876:
1620:Guanylate cyclase
1576:Adenylate cyclase
1318:(16): 8147–8154.
1218:enzyme.expasy.org
1135:Nucleic Acids Res
842:(12): 1659–1667.
751:
750:
334:in the family of
236:
235:
232:
231:
135:metabolic pathway
5666:
5631:
5630:
5622:
5494:Hanes–Woolf plot
5437:Enzyme activator
5432:Enzyme inhibitor
5406:Enzyme catalysis
5350:
5343:
5336:
5327:
5326:
5265:
5264:
5251:
5250:
4898:C-Jun N-terminal
4641:
4640:
4627:
4626:
4131:Rhodopsin kinase
4122:Rhodopsin kinase
4052:Protein kinase C
4043:Protein kinase C
4028:Protein kinase G
3989:Protein kinase A
3600:Protein kinase B
3532:
3531:
3518:
3517:
3494:
3487:
3480:
3471:
3470:
3455:Histidine kinase
3378:tyrosine kinases
3368:protein-tyrosine
3360:
3359:
3290:
3289:
3097:RNA polymerase I
2920:
2919:
2911:
2910:
2764:Aspartate kinase
2759:Phosphoglycerate
2576:
2575:
2532:
2525:
2518:
2509:
2508:
2335:Serine/threonine
2331:
2330:
2019:Serine/threonine
2015:
2014:
1635:Protein kinase G
1591:Protein kinase A
1547:
1546:
1538:
1537:
1473:
1466:
1459:
1450:
1449:
1421:
1420:
1403:(8): 3108–3116.
1391:
1385:
1384:
1374:
1342:
1336:
1335:
1306:
1300:
1299:
1297:
1296:
1290:iubmb.qmul.ac.uk
1282:
1276:
1275:
1273:
1272:
1258:
1252:
1251:
1249:
1248:
1234:
1228:
1227:
1225:
1224:
1210:
1204:
1203:
1175:
1169:
1168:
1158:
1126:
1120:
1119:
1109:
1077:
1071:
1070:
1060:
1036:
1030:
1029:
1019:
995:
989:
988:
960:
954:
953:
925:
919:
918:
908:
868:
862:
861:
851:
827:
771:prostate cancers
671:Protein kinase C
645:Protein kinase A
517:
516:
472:highly conserved
468:catalytic domain
388:
386:
385:
380:
369:ATP + a protein
189:
188:
41:
31:
19:
18:
5674:
5673:
5669:
5668:
5667:
5665:
5664:
5663:
5654:Protein kinases
5639:
5638:
5637:
5625:
5617:
5615:
5610:
5522:Oxidoreductases
5508:
5484:Enzyme kinetics
5472:
5468:List of enzymes
5441:
5410:
5381:Catalytic triad
5359:
5354:
5324:
5311:
5259:
5237:
5161:
5144:
5127:
5110:
5081:
4941:
4841:
4812:P70-S6 Kinase 1
4782:
4673:
4635:
4613:
4579:
4555:
4516:
4482:
4188:
4159:
4135:
4116:
4037:
4013:
3974:
3930:
3913:
3889:
3883:Aurora C kinase
3878:Aurora B kinase
3873:Aurora A kinase
3853:
3834:
3800:
3771:
3704:
3670:
3526:
3512:
3498:
3468:
3459:
3430:
3408:
3383:
3354:
3348:
3344:2.7.10-2.7.13:
3335:
3319:
3286:: miscellaneous
3274:
3248:
3230:
3207:
3190:exoribonuclease
3187:
3175:
3161:Polyadenylation
3078:
2904:
2898:
2886:
2868:
2864:
2858:
2842:
2804:
2791:
2768:
2740:
2570:
2564:
2556:
2550:
2536:
2506:
2501:
2489:
2438:
2417:
2392:
2376:
2348:
2315:
2306:Arginine kinase
2294:
2251:
2210:
2003:
1999:Phospholipase C
1982:
1952:
1873:
1855:
1785:
1752:
1738:
1653:
1648:G alpha subunit
1639:
1595:
1527:
1501:
1482:
1477:
1430:
1425:
1424:
1397:Cancer Research
1392:
1388:
1343:
1339:
1312:Cancer Research
1307:
1303:
1294:
1292:
1284:
1283:
1279:
1270:
1268:
1260:
1259:
1255:
1246:
1244:
1236:
1235:
1231:
1222:
1220:
1212:
1211:
1207:
1186:(1–2): 168–72.
1176:
1172:
1127:
1123:
1086:Mol. Biol. Cell
1078:
1074:
1037:
1033:
996:
992:
961:
957:
926:
922:
869:
865:
828:
824:
819:
786:
756:
541:casein kinase 2
504:
488:
480:pseudosubstrate
446:
434:
422:systematic name
374:
371:
370:
356:phosphorylation
42:
37:
17:
12:
11:
5:
5672:
5662:
5661:
5656:
5651:
5636:
5635:
5612:
5611:
5609:
5608:
5595:
5582:
5569:
5556:
5543:
5530:
5516:
5514:
5510:
5509:
5507:
5506:
5501:
5496:
5491:
5486:
5480:
5478:
5474:
5473:
5471:
5470:
5465:
5460:
5455:
5449:
5447:
5446:Classification
5443:
5442:
5440:
5439:
5434:
5429:
5424:
5418:
5416:
5412:
5411:
5409:
5408:
5403:
5398:
5393:
5388:
5383:
5378:
5373:
5367:
5365:
5361:
5360:
5353:
5352:
5345:
5338:
5330:
5321:
5320:
5317:
5316:
5313:
5312:
5310:
5309:
5304:
5299:
5294:
5289:
5284:
5279:
5273:
5271:
5261:
5260:
5247:
5246:
5243:
5242:
5239:
5238:
5236:
5235:
5230:
5225:
5220:
5215:
5210:
5205:
5200:
5199:
5198:
5193:
5188:
5183:
5172:
5170:
5169:(EC 2.7.11.30)
5163:
5162:
5160:
5159:
5155:
5153:
5152:(EC 2.7.11.29)
5146:
5145:
5143:
5142:
5138:
5136:
5135:(EC 2.7.11.28)
5129:
5128:
5126:
5125:
5121:
5119:
5118:(EC 2.7.11.27)
5112:
5111:
5109:
5108:
5103:
5098:
5092:
5090:
5089:(EC 2.7.11.26)
5083:
5082:
5080:
5079:
5074:
5069:
5068:
5067:
5062:
5057:
5052:
5047:
5042:
5037:
5027:
5026:
5025:
5020:
5015:
5010:
5000:
4999:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4952:
4950:
4949:(EC 2.7.11.25)
4943:
4942:
4940:
4939:
4938:
4937:
4932:
4927:
4917:
4916:
4915:
4910:
4905:
4895:
4894:
4893:
4888:
4883:
4878:
4873:
4868:
4863:
4852:
4850:
4849:(EC 2.7.11.24)
4843:
4842:
4840:
4839:
4834:
4829:
4824:
4819:
4814:
4809:
4804:
4799:
4793:
4791:
4790:(EC 2.7.11.23)
4784:
4783:
4781:
4780:
4775:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
4720:
4715:
4710:
4705:
4700:
4695:
4690:
4684:
4682:
4681:(EC 2.7.11.22)
4675:
4674:
4672:
4671:
4666:
4661:
4656:
4650:
4648:
4647:(EC 2.7.11.21)
4637:
4636:
4623:
4622:
4619:
4618:
4615:
4614:
4612:
4611:
4606:
4601:
4596:
4590:
4588:
4587:(EC 2.7.11.21)
4581:
4580:
4578:
4577:
4572:
4566:
4564:
4563:(EC 2.7.11.20)
4557:
4556:
4554:
4553:
4548:
4543:
4538:
4533:
4527:
4525:
4524:(EC 2.7.11.19)
4518:
4517:
4515:
4514:
4509:
4504:
4499:
4493:
4491:
4490:(EC 2.7.11.18)
4484:
4483:
4481:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4430:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4390:
4385:
4380:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4199:
4197:
4196:(EC 2.7.11.17)
4190:
4189:
4187:
4186:
4181:
4176:
4170:
4168:
4167:(EC 2.7.11.16)
4161:
4160:
4158:
4157:
4152:
4146:
4144:
4143:(EC 2.7.11.15)
4137:
4136:
4134:
4133:
4127:
4125:
4124:(EC 2.7.11.14)
4118:
4117:
4115:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4059:
4054:
4048:
4046:
4045:(EC 2.7.11.13)
4039:
4038:
4036:
4035:
4030:
4024:
4022:
4021:(EC 2.7.11.12)
4015:
4014:
4012:
4011:
4006:
4001:
3996:
3991:
3985:
3983:
3982:(EC 2.7.11.11)
3976:
3975:
3973:
3972:
3967:
3962:
3957:
3952:
3947:
3941:
3939:
3938:(EC 2.7.11.10)
3932:
3931:
3929:
3928:
3924:
3922:
3915:
3914:
3912:
3911:
3906:
3900:
3898:
3891:
3890:
3888:
3887:
3886:
3885:
3880:
3875:
3864:
3862:
3855:
3854:
3852:
3851:
3845:
3843:
3836:
3835:
3833:
3832:
3827:
3822:
3817:
3811:
3809:
3802:
3801:
3799:
3798:
3793:
3788:
3782:
3780:
3773:
3772:
3770:
3769:
3768:
3767:
3762:
3757:
3749:
3748:
3747:
3742:
3734:
3733:
3732:
3727:
3715:
3713:
3706:
3705:
3703:
3702:
3697:
3692:
3687:
3681:
3679:
3672:
3671:
3669:
3668:
3667:
3666:
3656:
3655:
3654:
3649:
3644:
3639:
3629:
3624:
3619:
3618:
3617:
3612:
3607:
3597:
3592:
3587:
3582:
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3541:
3539:
3528:
3527:
3514:
3513:
3497:
3496:
3489:
3482:
3474:
3465:
3464:
3461:
3460:
3458:
3457:
3452:
3447:
3441:
3439:
3432:
3431:
3429:
3428:
3419:
3417:
3410:
3409:
3407:
3406:
3397:
3395:
3385:
3384:
3382:
3381:
3372:
3370:
3357:
3352:
3346:protein kinase
3341:
3340:
3337:
3336:
3334:
3333:
3327:
3325:
3321:
3320:
3318:
3317:
3312:
3307:
3302:
3296:
3294:
3287:
3280:
3279:
3276:
3275:
3273:
3272:
3267:
3256:
3254:
3250:
3249:
3247:
3246:
3240:
3238:
3232:
3231:
3229:
3228:
3223:
3217:
3215:
3209:
3208:
3206:
3205:
3200:
3194:
3192:
3185:Phosphorolytic
3181:
3180:
3177:
3176:
3174:
3173:
3168:
3163:
3158:
3153:
3152:
3151:
3146:
3141:
3131:
3130:
3129:
3119:
3114:
3109:
3104:
3099:
3094:
3088:
3086:
3084:RNA polymerase
3080:
3079:
3077:
3076:
3075:
3074:
3064:
3060:
3059:
3058:
3057:
3052:
3047:
3036:
3035:
3034:
3029:
3024:
3019:
3008:
3002:
3001:
3000:
2993:
2988:
2983:
2978:
2967:
2966:
2965:
2958:
2953:
2948:
2943:
2932:
2928:
2926:
2924:DNA polymerase
2917:
2908:
2902:
2888:
2887:
2885:
2884:
2879:
2873:
2871:
2866:
2862:
2848:
2847:
2844:
2843:
2841:
2840:
2835:
2830:
2825:
2820:
2815:
2809:
2807:
2802:
2793:
2792:
2790:
2789:
2783:
2781:
2770:
2769:
2767:
2766:
2761:
2755:
2753:
2742:
2741:
2739:
2738:
2733:
2728:
2727:
2726:
2721:
2711:
2709:Diacylglycerol
2706:
2701:
2696:
2691:
2686:
2681:
2676:
2671:
2670:
2669:
2659:
2654:
2649:
2648:
2647:
2642:
2637:
2632:
2627:
2620:Phosphofructo-
2617:
2612:
2611:
2610:
2600:
2595:
2589:
2587:
2573:
2568:
2552:
2551:
2535:
2534:
2527:
2520:
2512:
2503:
2502:
2494:
2491:
2490:
2488:
2487:
2482:
2477:
2472:
2467:
2462:
2457:
2452:
2446:
2444:
2440:
2439:
2437:
2436:
2427:
2425:
2419:
2418:
2416:
2415:
2406:
2404:
2398:
2397:
2394:
2393:
2391:
2390:
2384:
2382:
2378:
2377:
2375:
2374:
2369:
2359:
2357:
2350:
2349:
2347:
2346:
2340:
2338:
2328:
2321:
2320:
2317:
2316:
2314:
2313:
2308:
2302:
2300:
2296:
2295:
2293:
2292:
2291:
2290:
2285:
2280:
2275:
2270:
2259:
2257:
2253:
2252:
2250:
2249:
2244:
2243:
2242:
2237:
2227:
2221:
2219:
2212:
2211:
2209:
2208:
2207:
2206:
2196:
2195:
2194:
2189:
2179:
2178:
2177:
2172:
2167:
2162:
2152:
2151:
2150:
2145:
2135:
2134:
2133:
2128:
2123:
2118:
2108:
2107:
2106:
2101:
2096:
2086:
2085:
2084:
2079:
2074:
2069:
2064:
2054:
2053:
2052:
2042:
2041:
2040:
2035:
2024:
2022:
2012:
2010:protein kinase
2005:
2004:
2002:
2001:
1996:
1990:
1988:
1984:
1983:
1981:
1980:
1975:
1970:
1964:
1962:
1958:
1957:
1954:
1953:
1951:
1950:
1945:
1940:
1935:
1930:
1925:
1920:
1919:
1918:
1913:
1908:
1898:
1893:
1887:
1885:
1879:
1878:
1875:
1874:
1872:
1871:
1866:
1860:
1857:
1856:
1854:
1853:
1852:
1851:
1846:
1841:
1836:
1831:
1826:
1821:
1816:
1811:
1806:
1801:
1796:
1791:
1783:
1780:
1779:
1778:
1773:
1768:
1763:
1758:
1750:
1743:
1740:
1739:
1737:
1736:
1735:
1734:
1729:
1724:
1719:
1714:
1709:
1704:
1699:
1694:
1689:
1684:
1679:
1674:
1669:
1664:
1659:
1651:
1644:
1641:
1640:
1638:
1637:
1632:
1627:
1622:
1617:
1612:
1606:
1604:
1597:
1596:
1594:
1593:
1588:
1583:
1578:
1573:
1572:
1571:
1556:
1554:
1544:
1542:Heterotrimeric
1535:
1529:
1528:
1526:
1525:
1520:
1515:
1509:
1507:
1503:
1502:
1500:
1499:
1490:
1488:
1484:
1483:
1476:
1475:
1468:
1461:
1453:
1447:
1446:
1441:
1429:
1428:External links
1426:
1423:
1422:
1386:
1357:(7): 781–796.
1337:
1301:
1277:
1253:
1229:
1205:
1170:
1141:(5): 1028–35.
1121:
1072:
1051:(20): 5763–5.
1031:
990:
955:
920:
863:
821:
820:
818:
815:
814:
813:
803:
793:
785:
782:
755:
752:
749:
748:
738:
733:
724:
723:
716:
710:
701:
700:
697:
691:
682:
681:
674:
668:
659:
658:
647:
642:
633:
632:
629:
624:
615:
614:
590:
583:
574:
573:
566:
556:
547:
546:
543:
537:
528:
527:
524:
521:
503:
500:
487:
484:
445:
442:
433:
430:
415:phosphoprotein
393:Thus, the two
391:
390:
378:
350:side chain in
302:phosphorylates
298:protein kinase
234:
233:
230:
229:
224:
218:
217:
212:
206:
205:
200:
194:
193:
185:
184:
175:
169:
168:
157:
150:
149:
144:
138:
137:
132:
126:
125:
120:
114:
113:
108:
102:
101:
96:
90:
89:
84:
78:
77:
73:
72:
67:
61:
60:
55:
49:
48:
44:
43:
32:
24:
23:
15:
9:
6:
4:
3:
2:
5671:
5660:
5657:
5655:
5652:
5650:
5647:
5646:
5644:
5634:
5629:
5624:
5623:
5620:
5606:
5602:
5601:
5596:
5593:
5589:
5588:
5583:
5580:
5576:
5575:
5570:
5567:
5563:
5562:
5557:
5554:
5550:
5549:
5544:
5541:
5537:
5536:
5531:
5528:
5524:
5523:
5518:
5517:
5515:
5511:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5481:
5479:
5475:
5469:
5466:
5464:
5463:Enzyme family
5461:
5459:
5456:
5454:
5451:
5450:
5448:
5444:
5438:
5435:
5433:
5430:
5428:
5427:Cooperativity
5425:
5423:
5420:
5419:
5417:
5413:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5386:Oxyanion hole
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5368:
5366:
5362:
5358:
5351:
5346:
5344:
5339:
5337:
5332:
5331:
5328:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5274:
5272:
5270:
5266:
5262:
5257:
5252:
5248:
5234:
5231:
5229:
5226:
5224:
5221:
5219:
5216:
5214:
5211:
5209:
5206:
5204:
5201:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5178:
5177:
5174:
5173:
5171:
5168:
5164:
5157:
5156:
5154:
5151:
5147:
5140:
5139:
5137:
5134:
5130:
5123:
5122:
5120:
5117:
5113:
5107:
5104:
5102:
5099:
5097:
5094:
5093:
5091:
5088:
5084:
5078:
5075:
5073:
5070:
5066:
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5032:
5031:
5028:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5005:
5004:
5001:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4958:
4957:
4954:
4953:
4951:
4948:
4944:
4936:
4933:
4931:
4928:
4926:
4923:
4922:
4921:
4918:
4914:
4911:
4909:
4906:
4904:
4901:
4900:
4899:
4896:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4858:
4857:
4854:
4853:
4851:
4848:
4844:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4794:
4792:
4789:
4785:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4685:
4683:
4680:
4676:
4670:
4667:
4665:
4662:
4660:
4657:
4655:
4652:
4651:
4649:
4646:
4642:
4638:
4633:
4628:
4624:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4591:
4589:
4586:
4582:
4576:
4573:
4571:
4568:
4567:
4565:
4562:
4558:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4528:
4526:
4523:
4519:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4494:
4492:
4489:
4485:
4479:
4476:
4474:
4471:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4200:
4198:
4195:
4191:
4185:
4182:
4180:
4177:
4175:
4172:
4171:
4169:
4166:
4162:
4156:
4153:
4151:
4148:
4147:
4145:
4142:
4138:
4132:
4129:
4128:
4126:
4123:
4119:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4049:
4047:
4044:
4040:
4034:
4031:
4029:
4026:
4025:
4023:
4020:
4016:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3986:
3984:
3981:
3977:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3942:
3940:
3937:
3933:
3926:
3925:
3923:
3921:(EC 2.7.11.9)
3920:
3916:
3910:
3907:
3905:
3902:
3901:
3899:
3897:(EC 2.7.11.8)
3896:
3892:
3884:
3881:
3879:
3876:
3874:
3871:
3870:
3869:
3868:Aurora kinase
3866:
3865:
3863:
3861:(EC 2.7.11.7)
3860:
3856:
3850:
3847:
3846:
3844:
3842:(EC 2.7.11.6)
3841:
3837:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3812:
3810:
3808:(EC 2.7.11.5)
3807:
3803:
3797:
3794:
3792:
3789:
3787:
3784:
3783:
3781:
3779:(EC 2.7.11.4)
3778:
3774:
3766:
3763:
3761:
3758:
3756:
3753:
3752:
3750:
3746:
3743:
3741:
3738:
3737:
3735:
3731:
3728:
3726:
3723:
3722:
3720:
3717:
3716:
3714:
3712:(EC 2.7.11.3)
3711:
3707:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3682:
3680:
3678:(EC 2.7.11.2)
3677:
3673:
3665:
3662:
3661:
3660:
3657:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3634:
3633:
3632:EIF-2 kinases
3630:
3628:
3625:
3623:
3620:
3616:
3613:
3611:
3608:
3606:
3603:
3602:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3542:
3540:
3538:(EC 2.7.11.1)
3537:
3533:
3529:
3524:
3519:
3515:
3510:
3506:
3502:
3495:
3490:
3488:
3483:
3481:
3476:
3475:
3472:
3456:
3453:
3451:
3448:
3446:
3443:
3442:
3440:
3437:
3433:
3427:
3426:
3421:
3420:
3418:
3415:
3411:
3405:
3404:
3399:
3398:
3396:
3394:
3390:
3386:
3380:
3379:
3374:
3373:
3371:
3369:
3365:
3361:
3358:
3355:
3347:
3342:
3332:
3329:
3328:
3326:
3322:
3316:
3313:
3311:
3308:
3306:
3303:
3301:
3298:
3297:
3295:
3291:
3288:
3285:
3281:
3271:
3268:
3265:
3261:
3258:
3257:
3255:
3251:
3245:
3242:
3241:
3239:
3237:
3233:
3227:
3224:
3222:
3219:
3218:
3216:
3214:
3210:
3204:
3201:
3199:
3196:
3195:
3193:
3191:
3186:
3182:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3150:
3147:
3145:
3142:
3140:
3137:
3136:
3135:
3132:
3128:
3125:
3124:
3123:
3120:
3118:
3115:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3089:
3087:
3085:
3081:
3073:
3070:
3069:
3068:
3065:
3062:
3061:
3056:
3053:
3051:
3048:
3046:
3043:
3042:
3040:
3037:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3014:
3012:
3009:
3006:
3003:
2999:
2998:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2973:
2971:
2968:
2964:
2963:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2938:
2936:
2933:
2930:
2929:
2927:
2925:
2921:
2918:
2916:
2912:
2909:
2906:
2897:
2893:
2889:
2883:
2880:
2878:
2875:
2874:
2872:
2869:
2857:
2853:
2849:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2810:
2808:
2805:
2798:
2794:
2788:
2785:
2784:
2782:
2779:
2775:
2771:
2765:
2762:
2760:
2757:
2756:
2754:
2751:
2747:
2743:
2737:
2734:
2732:
2729:
2725:
2724:Class II PI 3
2722:
2720:
2717:
2716:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2699:Deoxycytidine
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2668:
2667:ADP-thymidine
2665:
2664:
2663:
2660:
2658:
2655:
2653:
2650:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2628:
2626:
2623:
2622:
2621:
2618:
2616:
2613:
2609:
2606:
2605:
2604:
2601:
2599:
2596:
2594:
2591:
2590:
2588:
2585:
2581:
2577:
2574:
2571:
2563:
2559:
2553:
2548:
2544:
2540:
2533:
2528:
2526:
2521:
2519:
2514:
2513:
2510:
2500:
2499:
2492:
2486:
2483:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2456:
2453:
2451:
2448:
2447:
2445:
2441:
2435:
2434:
2429:
2428:
2426:
2424:
2420:
2414:
2413:
2408:
2407:
2405:
2403:
2399:
2389:
2386:
2385:
2383:
2379:
2373:
2370:
2368:
2364:
2361:
2360:
2358:
2355:
2351:
2345:
2342:
2341:
2339:
2336:
2332:
2329:
2327:
2322:
2312:
2309:
2307:
2304:
2303:
2301:
2297:
2289:
2286:
2284:
2281:
2279:
2276:
2274:
2271:
2269:
2266:
2265:
2264:
2261:
2260:
2258:
2254:
2248:
2245:
2241:
2238:
2236:
2233:
2232:
2231:
2228:
2226:
2223:
2222:
2220:
2217:
2213:
2205:
2202:
2201:
2200:
2197:
2193:
2190:
2188:
2185:
2184:
2183:
2180:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2157:
2156:
2153:
2149:
2146:
2144:
2141:
2140:
2139:
2136:
2132:
2129:
2127:
2124:
2122:
2119:
2117:
2114:
2113:
2112:
2109:
2105:
2102:
2100:
2097:
2095:
2092:
2091:
2090:
2087:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2059:
2058:
2055:
2051:
2048:
2047:
2046:
2043:
2039:
2036:
2034:
2031:
2030:
2029:
2028:Casein kinase
2026:
2025:
2023:
2020:
2016:
2013:
2011:
2006:
2000:
1997:
1995:
1992:
1991:
1989:
1985:
1979:
1976:
1974:
1971:
1969:
1966:
1965:
1963:
1959:
1949:
1946:
1944:
1941:
1939:
1936:
1934:
1931:
1929:
1926:
1924:
1921:
1917:
1914:
1912:
1909:
1907:
1904:
1903:
1902:
1899:
1897:
1894:
1892:
1889:
1888:
1886:
1884:
1880:
1870:
1867:
1865:
1862:
1861:
1858:
1850:
1847:
1845:
1842:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1820:
1817:
1815:
1812:
1810:
1807:
1805:
1802:
1800:
1797:
1795:
1792:
1790:
1787:
1786:
1781:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1753:
1748:
1745:
1744:
1741:
1733:
1730:
1728:
1725:
1723:
1720:
1718:
1715:
1713:
1710:
1708:
1705:
1703:
1700:
1698:
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1678:
1675:
1673:
1670:
1668:
1665:
1663:
1660:
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1655:
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1649:
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1636:
1633:
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1628:
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1623:
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1618:
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1613:
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1608:
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1602:
1598:
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1579:
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1570:
1566:
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1558:
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1555:
1552:
1548:
1545:
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1539:
1536:
1534:
1530:
1524:
1521:
1519:
1516:
1514:
1511:
1510:
1508:
1504:
1498:
1497:
1492:
1491:
1489:
1485:
1481:
1474:
1469:
1467:
1462:
1460:
1455:
1454:
1451:
1445:
1442:
1439:
1435:
1432:
1431:
1418:
1414:
1410:
1406:
1402:
1398:
1390:
1382:
1378:
1373:
1368:
1364:
1360:
1356:
1352:
1348:
1341:
1333:
1329:
1325:
1321:
1317:
1313:
1305:
1291:
1287:
1281:
1267:
1266:www.genome.jp
1263:
1257:
1243:
1242:www.genome.jp
1239:
1233:
1219:
1215:
1209:
1201:
1197:
1193:
1189:
1185:
1181:
1174:
1166:
1162:
1157:
1152:
1148:
1144:
1140:
1136:
1132:
1125:
1117:
1113:
1108:
1103:
1099:
1095:
1092:(3): 247–60.
1091:
1087:
1083:
1076:
1068:
1064:
1059:
1054:
1050:
1046:
1045:J. Biol. Chem
1042:
1035:
1027:
1023:
1018:
1013:
1010:(2): 425–34.
1009:
1005:
1004:J. Biol. Chem
1001:
994:
986:
982:
978:
974:
970:
966:
959:
951:
947:
943:
939:
936:(2): 574–84.
935:
931:
924:
916:
912:
907:
902:
898:
894:
890:
886:
882:
878:
874:
867:
859:
855:
850:
845:
841:
837:
833:
826:
822:
811:
807:
804:
801:
797:
794:
791:
788:
787:
781:
779:
774:
772:
768:
763:
761:
746:
743:
739:
737:
734:
732:
729:
726:
725:
721:
717:
714:
711:
709:
706:
703:
702:
698:
695:
692:
690:
687:
684:
683:
679:
675:
672:
669:
667:
664:
661:
660:
656:
652:
648:
646:
643:
641:
638:
635:
634:
630:
628:
625:
623:
620:
617:
616:
612:
608:
604:
599:
595:
591:
588:
584:
582:
579:
576:
575:
571:
567:
564:
560:
557:
555:
552:
549:
548:
544:
542:
538:
536:
533:
530:
529:
525:
522:
519:
518:
515:
513:
509:
499:
496:
493:
483:
481:
477:
473:
469:
465:
461:
457:
456:
451:
450:phosphorylate
441:
439:
429:
427:
423:
418:
416:
412:
408:
404:
400:
396:
368:
367:
366:
363:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
320:
318:
314:
311:
307:
303:
299:
295:
292:
288:
285:
281:
274:
273:phosphoserine
270:
264:
260:
254:
250:
244:
240:
228:
225:
223:
219:
216:
213:
211:
207:
204:
201:
199:
195:
190:
186:
183:
179:
176:
174:
173:Gene Ontology
170:
167:
164:
161:
158:
155:
151:
148:
145:
143:
139:
136:
133:
131:
127:
124:
121:
119:
115:
112:
111:NiceZyme view
109:
107:
103:
100:
97:
95:
91:
88:
85:
83:
79:
74:
71:
68:
66:
62:
59:
56:
54:
50:
45:
40:
36:
30:
25:
20:
5600:Translocases
5597:
5584:
5571:
5558:
5545:
5535:Transferases
5532:
5519:
5376:Binding site
4807:P70S6 kinase
4631:
3522:
3504:
3422:
3400:
3392:
3375:
2996:
2961:
2719:Class I PI 3
2684:Pantothenate
2555:2.7.1-2.7.4:
2539:Transferases
2495:
2430:
2409:
2045:eIF-2 kinase
2018:
1493:
1400:
1396:
1389:
1354:
1350:
1340:
1315:
1311:
1304:
1293:. Retrieved
1289:
1280:
1269:. Retrieved
1265:
1256:
1245:. Retrieved
1241:
1232:
1221:. Retrieved
1217:
1208:
1183:
1179:
1173:
1138:
1134:
1124:
1089:
1085:
1075:
1048:
1044:
1034:
1007:
1003:
993:
971:(3): 515–7.
968:
964:
958:
933:
929:
923:
883:(1): 19790.
880:
876:
866:
839:
835:
825:
800:pseudoenzyme
796:Pseudokinase
775:
764:
757:
744:
526:Description
505:
497:
489:
453:
447:
435:
425:
419:
392:
364:
336:transferases
327:
321:
279:
277:
99:BRENDA entry
5371:Active site
5258:(EC 2.7.12)
4645:Polo kinase
4585:Polo kinase
3270:Transposase
3260:Recombinase
2905:-nucleoside
2731:Sphingosine
1732:GNA15/GNA16
1518:Calcineurin
1286:"EC 2.7.11"
464:ionic bonds
462:forces and
460:hydrophobic
444:Selectivity
326:, the term
87:IntEnz view
47:Identifiers
5643:Categories
5574:Isomerases
5548:Hydrolases
5415:Regulation
3936:IÎşB kinase
3511:2.7.11-12)
3072:Telomerase
2915:Polymerase
2689:Mevalonate
2652:Riboflavin
2543:phosphorus
2138:Lim kinase
2089:IÎşB kinase
1610:Transducin
1295:2023-12-25
1271:2023-12-25
1247:2023-12-25
1223:2023-12-25
817:References
720:calmodulin
598:retrovirus
520:EC number
492:EC numbers
486:EC numbers
395:substrates
342:atom of a
324:enzymology
156:structures
123:KEGG entry
70:9026-43-1
5649:EC 2.7.11
5453:EC number
4062:PKC alpha
3264:Integrase
3188:3' to 5'
2833:Guanylate
2828:Uridylate
2818:Adenylate
2662:Thymidine
2657:Shikimate
2496:see also
2402:Apoptosis
1883:Monomeric
1615:Gustducin
1533:G protein
836:Structure
731:2.7.11.19
722:complex.
708:2.7.11.17
689:2.7.11.24
666:2.7.11.13
655:α helices
640:2.7.11.11
438:apoptosis
377:⇌
348:threonine
317:threonine
263:phosphate
253:threonine
76:Databases
5477:Kinetics
5401:Cofactor
5364:Activity
4418:KIAA0999
4313:MAPKAPK5
4308:MAPKAPK3
4303:MAPKAPK2
3198:RNase PH
2806:acceptor
2787:Creatine
2780:acceptor
2752:acceptor
2694:Pyruvate
2679:Glycerol
2640:Platelet
2615:Galacto-
2586:acceptor
2354:Tyrosine
2299:Arginine
2216:Tyrosine
1417:15833840
1381:27101098
1332:16912193
1200:11267674
915:31875044
858:12467573
784:See also
678:isozymes
622:2.7.11.1
594:oncogene
581:2.7.11.1
554:2.7.11.1
535:2.7.11.1
432:Function
407:products
352:proteins
306:OH group
300:, that
287:2.7.11.-
227:proteins
215:articles
203:articles
160:RCSB PDB
58:2.7.11.-
5633:Biology
5587:Ligases
5357:Enzymes
5077:MAP3K14
5055:MAP3K11
5050:MAP3K10
5040:MAP3K13
5035:MAP3K12
4837:RPS6KC1
4832:RPS6KA1
4827:RPS6KA3
4822:RPS6KA2
4817:RPS6KB2
4802:RPS6KA4
4797:RPS6KA5
4448:Kalirin
4413:SNF1LK2
3652:EIF2AK4
3647:EIF2AK3
3501:Kinases
3149:PrimPol
3134:Primase
2608:Hepatic
2603:Fructo-
2480:EDARADD
2465:Mucin-4
2204:RPS6KA1
2050:EIF2AK3
1506:Calcium
1372:7534810
1165:9102632
1116:8485317
1067:4310608
1026:4312674
985:5456997
950:2835010
906:6930252
885:Bibcode
696:(MAPKs)
673:('PKC')
651:β sheet
607:insulin
565:kinases
403:protein
332:enzymes
308:of the
289:) is a
182:QuickGO
147:profile
130:MetaCyc
65:CAS no.
5619:Portal
5561:Lyases
5307:MAP2K7
5302:MAP2K6
5297:MAP2K5
5292:MAP2K4
5287:MAP2K3
5282:MAP2K2
5277:MAP2K1
5228:ACVRL1
5223:ACVR2B
5218:ACVR2A
5213:ACVR1C
5208:ACVR1B
5191:BMPR1B
5186:BMPR1A
5060:MAP3K7
5045:MAP3K9
4996:MAP3K8
4991:MAP3K7
4986:MAP3K6
4981:MAP3K5
4976:MAP3K4
4971:MAP3K3
4966:MAP3K2
4961:MAP3K1
4935:MAPK14
4930:MAPK13
4925:MAPK11
4913:MAPK10
4891:MAPK15
4886:MAPK12
4778:CDC2L1
4753:CDC2L5
4428:SNF1LK
4253:CAMK2G
4248:CAMK2D
4243:CAMK2B
4238:CAMK2A
4228:CAMK1G
4223:CAMK1D
4218:CAMK1B
4213:CAMK1A
4067:PRKCB1
4004:PRKACA
3999:PRKACB
3994:PRKACG
3970:IKBKAP
3796:BCKDHB
3791:BCKDHA
3765:PRKAG3
3760:PRKAG2
3755:PRKAG1
3745:PRKAB2
3740:PRKAB1
3730:PRKAA2
3725:PRKAA1
3570:STK38L
3436:2.7.13
3414:2.7.12
3389:2.7.11
3364:2.7.10
3203:PNPase
3171:PNPase
3127:POLRMT
3122:ssRNAP
2635:Muscle
2598:Gluco-
2562:kinase
2485:PRKCSH
2324:Other
2273:DYRK1B
2268:DYRK1A
2008:Other
1978:Cyclin
1961:Cyclin
1440:(MeSH)
1415:
1379:
1369:
1330:
1198:
1163:
1156:146536
1153:
1114:
1107:300923
1104:
1065:
1024:
983:
948:
913:
903:
856:
760:cancer
745:et al.
589:kinase
476:kinome
401:and a
344:serine
340:oxygen
313:serine
294:enzyme
291:kinase
243:serine
210:PubMed
192:Search
178:AmiGO
166:PDBsum
106:ExPASy
94:BRENDA
82:IntEnz
53:EC no.
5513:Types
5269:MAP2K
5203:ACVR1
5196:BMPR2
5181:BMPR1
5106:GSK-3
4947:MAP3K
4908:MAPK9
4903:MAPK8
4881:MAPK7
4876:MAPK6
4871:MAPK4
4866:MAPK3
4861:MAPK1
4773:PFTK1
4768:PCTK3
4763:PCTK2
4758:PCTK1
4748:CDK12
4743:CDK10
4718:CDKL5
4698:CDKL2
4575:STK19
4570:EEF2K
4551:PHKG2
4546:PHKG1
4536:PHKA2
4531:PHKA1
4512:MYLK4
4507:MYLK3
4502:MYLK2
4478:DCLK1
4473:Titin
4463:TRIB3
4458:TRIB2
4453:TRIB1
4443:TSSK2
4423:STK40
4408:PSKH1
4403:PRKD3
4398:PRKD2
4378:PHKG2
4373:PHKG1
4363:OBSCN
4358:NUAK2
4353:NUAK1
4348:MKNK2
4343:MKNK1
4333:MARK4
4328:MARK3
4323:MARK2
4318:MARK1
4298:STK11
4293:DAPK3
4288:DAPK2
4283:DAPK1
4278:CHEK2
4273:CHEK1
4258:CAMK4
4233:CAMK2
4208:CAMK1
4203:BRSK2
4097:PRKCQ
4092:PRKCI
4087:PRKCG
4082:PRKCH
4077:PRKCE
4072:PRKCD
4033:PRKG1
3965:IKBKG
3960:IKBKE
3909:STK10
3904:FASTK
3830:IDH3G
3825:IDH3B
3820:IDH3A
3786:BCKDK
3580:ROCK1
3565:STK38
3560:MAST2
3555:MAST1
3550:LATS2
3545:LATS1
3284:2.7.8
3253:Other
2892:2.7.7
2852:2.7.6
2797:2.7.4
2774:2.7.3
2746:2.7.2
2630:Liver
2593:Hexo-
2580:2.7.1
2443:Other
2381:both:
2288:DYRK4
2283:DYRK3
2278:DYRK2
2240:PTK2B
2225:ZAP70
2192:ROCK2
2187:ROCK1
2148:LIMK2
2143:LIMK1
2131:IRAK4
2126:IRAK3
2121:IRAK2
2116:IRAK1
2104:IKBKG
2082:GSK3B
2077:GSK3A
2072:GSK-3
1987:Lipid
1938:Rhebs
1849:BSCL2
1844:GNG13
1839:GNG12
1834:GNG11
1829:GNG10
1794:GNGT2
1789:GNGT1
1727:GNA14
1722:GNA13
1717:GNA12
1712:GNA11
1687:GNAT3
1682:GNAT2
1677:GNAT1
1672:GNAI3
1667:GNAI2
1662:GNAI1
1657:GNAO1
742:Krebs
627:Pelle
523:Name
502:Types
142:PRIAM
5605:list
5598:EC7
5592:list
5585:EC6
5579:list
5572:EC5
5566:list
5559:EC4
5553:list
5546:EC3
5540:list
5533:EC2
5527:list
5520:EC1
5096:TPK1
5072:CDC7
5030:MLKs
5023:KSR2
5018:KSR1
5013:BRAF
5008:ARAF
5003:RAFs
4738:CDK9
4733:CDK8
4728:CDK7
4723:CDK6
4713:CDK5
4708:CDK4
4703:CDK3
4693:CDK2
4688:CDK1
4669:PLK4
4664:PLK3
4659:PLK2
4654:PLK1
4609:PLK4
4604:PLK3
4599:PLK2
4594:PLK1
4541:PHKB
4497:MYLK
4468:TRIO
4438:SPEG
4433:SNRK
4393:PKD1
4388:PIM2
4383:PIM1
4368:PASK
4338:MELK
4268:CASK
4263:MLCK
4184:GRK6
4179:GRK5
4174:GRK4
4112:PKN3
4107:PKN2
4009:PRKY
3955:TBK1
3950:IKK2
3945:CHUK
3849:STK4
3815:IDH2
3700:PDK4
3695:PDK3
3690:PDK2
3685:PDK1
3664:WEE1
3659:Wee1
3627:mTOR
3615:AKT3
3610:AKT2
3605:AKT1
3595:SGK3
3590:SGK2
3423:see
3401:see
3376:see
2750:COOH
2549:2.7)
2431:see
2410:see
2311:McsB
2235:PTK2
2175:PAK4
2170:PAK3
2165:PAK2
2160:PAK1
2099:IKK2
2094:CHUK
2067:GSK2
2062:GSK1
1948:RGKs
1943:Raps
1928:Arfs
1923:Rhos
1916:NRAS
1911:KRAS
1906:HRAS
1896:Rabs
1891:ARFs
1824:GNG8
1819:GNG7
1814:GNG5
1809:GNG4
1804:GNG3
1799:GNG2
1776:GNB5
1771:GNB4
1766:GNB3
1761:GNB2
1756:GNB1
1707:GNAQ
1702:GNAL
1697:GNAS
1692:GNAZ
1625:cGMP
1601:cGMP
1581:cAMP
1551:cAMP
1494:see
1413:PMID
1377:PMID
1328:PMID
1196:PMID
1184:1518
1161:PMID
1112:PMID
1063:PMID
1022:PMID
981:PMID
946:PMID
911:PMID
854:PMID
420:The
413:and
409:are
304:the
222:NCBI
163:PDBe
118:KEGG
39:1mq4
5101:TTK
5065:ZAK
3642:HRI
3637:PKR
3585:SGK
3575:CIT
3166:PAP
3107:III
3041:/Y
3032:TDT
3013:/X
3005:III
2997:Pfu
2972:/B
2962:Taq
2937:/A
2704:PFP
2674:NAD
2247:BTK
1933:Ran
1901:Ras
1487:MAP
1405:doi
1367:PMC
1359:doi
1320:doi
1188:doi
1151:PMC
1143:doi
1102:PMC
1094:doi
1053:doi
1049:244
1012:doi
1008:245
973:doi
969:212
938:doi
934:262
901:PMC
893:doi
844:doi
747:).
596:of
587:AKT
570:Raf
563:Raf
559:Mos
411:ADP
399:ATP
346:or
322:In
315:or
198:PMC
154:PDB
35:PDB
5645::
3751:Îł
3736:β
3721:α
3509:EC
3503::
3391::
3366::
3351:PO
3112:IV
3102:II
3011:IV
3007:/C
2970:II
2956:T7
2901:PO
2894::
2854::
2801:PO
2799::
2776::
2748::
2584:OH
2582::
2567:PO
2547:EC
2541::
2365::
1569:Gi
1565:Gs
1411:.
1401:65
1399:.
1375:.
1365:.
1355:25
1353:.
1349:.
1326:.
1316:66
1314:.
1288:.
1264:.
1240:.
1216:.
1194:.
1182:.
1159:.
1149:.
1139:25
1137:.
1133:.
1110:.
1100:.
1088:.
1084:.
1061:.
1047:.
1043:.
1020:.
1006:.
1002:.
979:.
967:.
944:.
932:.
909:.
899:.
891:.
879:.
875:.
852:.
840:10
838:.
834:.
773:.
728:EC
705:EC
686:EC
663:EC
637:EC
619:EC
613:.
578:EC
551:EC
532:EC
428:.
417:.
362:.
284:EC
278:A
180:/
5621::
5607:)
5603:(
5594:)
5590:(
5581:)
5577:(
5568:)
5564:(
5555:)
5551:(
5542:)
5538:(
5529:)
5525:(
5349:e
5342:t
5335:v
5158:-
5141:-
5124:-
3927:-
3507:(
3493:e
3486:t
3479:v
3353:4
3349:(
3266:)
3262:(
3144:2
3139:1
3117:V
3055:Îş
3050:Îą
3045:η
3039:V
3027:ÎĽ
3022:λ
3017:β
2991:ζ
2986:ε
2981:δ
2976:α
2951:ν
2946:θ
2941:Îł
2935:I
2907:)
2903:4
2899:(
2870:)
2867:7
2865:O
2863:2
2861:P
2859:(
2803:4
2778:N
2645:2
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