304:
281:
203:
178:
310:
209:
31:
2881:
57:
1440:
Recently, sudden cardiac death in several young individuals in the Amish community (four of which were from the same family) was traced to homozygous duplication of a mutant RyR2 gene. Normal (wild type) RyR2 functions primarily in the myocardium (heart muscle).
1413:, enabling cardiac muscle contraction. RYR2 channels are associated with many cellular functions, including mitochondrial metabolism, gene expression and cell survival, in addition to their role in cardiomyocyte contraction.
1421:
Deleterious mutations of the ryanodine receptor family, and especially the RYR2 receptor, lead to a constellation of pathologies leading to both acute and chronic heart failure collectively known as "Ryanopathies."
2602:
Martin C, Chapman KE, Seckl JR, Ashley RH (July 1998). "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum".
317:
216:
1366: found in a 1:4 stoichiometric ratio. Calcium channel function is affected by the specific type of FK506 isomer interacting with the RYR2 protein, due to binding differences and other factors.
2495:
Rampazzo A, Nava A, Erne P, Eberhard M, Vian E, Slomp P, et al. (November 1995). "A new locus for arrhythmogenic right ventricular cardiomyopathy (ARVD2) maps to chromosome 1q42-q43".
2835:
Jeyakumar LH, Ballester L, Cheng DS, McIntyre JO, Chang P, Olivey HE, et al. (March 2001). "FKBP binding characteristics of cardiac microsomes from diverse vertebrates".
2215:
Wehrens XH, Lehnart SE, Reiken SR, Marks AR (April 2004). "Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor".
3702:
4612:
2675:
Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M (May 2000). "Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain".
1693:"Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)"
1430:
1921:"Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 Among Children With Exertion-Related Unexplained Sudden Deaths in the Amish Community"
4347:
3599:
3532:
1069:
139:
1050:
1394:. This binding causes the release of calcium through RYR2 from the sarcoplasmic reticulum into the cytosol, where it binds to the C domain of
1591:
1573:
2935:
1482:
2714:"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts"
2026:"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts"
1434:
1269:
1276:
1807:"Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo"
1611:"Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum"
4543:
4526:
4521:
4516:
4511:
2526:"The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis"
1905:
2326:"Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia"
4548:
3646:
2918:
2423:
Ma J, Hayek SM, Bhat MB (2005). "Membrane topology and membrane retention of the ryanodine receptor calcium release channel".
1556:
5159:
5149:
4600:
3781:
54:
4498:
3519:
2802:"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia"
1535:
4284:
303:
280:
4877:
3876:
3654:
2970:
1560:
1539:
1351:
1744:"Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks"
4899:
1114:
2877:
GeneReviews/NCBI/NIH/UW entry on
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
5108:
3019:
2295:
Ogawa Y, Kurebayashi N, Murayama T (1999). "Ryanodine receptor isoforms in excitation-contraction coupling".
1095:
4474:
3386:
2565:"Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium"
1485:(via phosphorylation at serine positions S2808 and S2814 in humans and rodents, S2809 and S2815 in rabbits)
202:
177:
119:
2075:"Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers"
4749:
2757:"Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia"
1453:
2927:
2911:
2524:
Tunwell RE, Wickenden C, Bertrand BM, Shevchenko VI, Walsh MB, Allen PD, et al. (September 1996).
316:
215:
5103:
3313:
1919:
Tester DJ, Bombei HM, Fitzgerald KK, Giudicessi JR, Pitel BA, Thorland EC, et al. (March 2020).
309:
208:
106:
5093:
3354:
3230:
2896:
2890:
1652:"Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes"
127:
2394:
Danieli GA, Rampazzo A (May 2002). "Genetics of arrhythmogenic right ventricular cardiomyopathy".
2176:"Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity"
5098:
2886:
1650:
Otsu K, Fujii J, Periasamy M, Difilippantonio M, Uppender M, Ward DC, et al. (August 1993).
1252:
1231:
1205:
1184:
810:
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
5129:
3121:
3108:
3095:
3075:
3062:
3027:
2755:
Laitinen PJ, Brown KM, Piippo K, Swan H, Devaney JM, Brahmbhatt B, et al. (January 2001).
2073:
Marx SO, Reiken S, Hisamatsu Y, Gaburjakova M, Gaburjakova J, Yang YM, et al. (May 2001).
1805:
Bround MJ, Wambolt R, Luciani DS, Kulpa JE, Rodrigues B, Brownsey RW, et al. (June 2013).
1391:
1387:
1375:
2712:
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, et al. (May 2000).
2024:
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, et al. (May 2000).
5154:
2904:
2882:
OMIM entries on
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
1968:
Bround MJ, Asghari P, Wambolt RB, Bohunek L, Smits C, Philit M, et al. (December 2012).
1499:
1493:
1363:
1691:
Tiso N, Stephan DA, Nava A, Bagattin A, Devaney JM, Stanchi F, et al. (February 2001).
2800:
Priori SG, Napolitano C, Tiso N, Memmi M, Vignati G, Bloise R, et al. (January 2001).
1444:
Mice with genetically reduced RYR2 exhibit a lower basal heart rate and fatal arrhythmias.
191:
147:
8:
2127:"Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes"
1502:(dephosphorylation at serine position S2814 in rodents<ref name = "Huke_2008" / >)
4469:
3345:
2992:
2743:
2700:
2658:
2641:
2628:
2585:
2564:
2546:
2525:
2448:
2228:
2151:
2126:
2099:
2074:
2055:
1994:
1969:
1945:
1920:
1882:
1857:
1833:
1806:
1768:
1743:
1512:
1386:. To enable cardiac muscle contraction, calcium influx through voltage-gated
1332:
151:
2872:
GeneReviews/NCBI/NIH/UW entry on
Catecholaminergic Polymorphic Ventricular Tachycardia
2730:
2713:
2688:
2616:
2308:
2192:
2175:
2042:
2025:
1627:
1610:
1374:
The RYR2 protein functions as the major component of a calcium channel located in the
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
587:
3507:
2852:
2823:
2788:
2735:
2692:
2663:
2620:
2590:
2551:
2512:
2483:
2440:
2411:
2407:
2382:
2347:
2312:
2273:
2232:
2197:
2156:
2104:
2047:
1999:
1950:
1887:
1838:
1773:
1724:
1673:
1632:
1390: in the plasma membrane allows calcium ions to bind to RYR2 located on the
99:
47:
2704:
2632:
2452:
4276:
3257:
2844:
2813:
2778:
2768:
2747:
2725:
2684:
2653:
2612:
2580:
2572:
2541:
2533:
2504:
2473:
2432:
2403:
2372:
2337:
2304:
2263:
2224:
2187:
2146:
2138:
2094:
2086:
2059:
2037:
1989:
1981:
1940:
1932:
1877:
1869:
1828:
1818:
1763:
1755:
1714:
1704:
1663:
1622:
1460:
396:
327:
271:
226:
1759:
131:
4812:
2952:
2460:
Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI (November 1995).
2250:
Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI (November 1995).
1936:
371:
155:
1609:
Otsu K, Willard HF, Khanna VK, Zorzato F, Green NM, MacLennan DH (August 1990).
1596:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1578:
National Center for
Biotechnology Information, U.S. National Library of Medicine
975:
positive regulation of ATPase-coupled calcium transmembrane transporter activity
4608:
3295:
2436:
2142:
472:
2876:
2871:
1970:"Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice"
1858:"'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure"
1742:
Guo T, Cornea RL, Huke S, Camors E, Yang Y, Picht E, et al. (June 2010).
1354:, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions.
5143:
4562:
4235:
2818:
2801:
2773:
2756:
2478:
2461:
2268:
2251:
574:
4595:
4493:
2508:
1823:
532:
410:
4915:
4306:
2856:
2848:
2827:
2792:
2739:
2696:
2667:
2444:
2415:
2386:
2351:
2316:
2236:
2160:
2108:
2051:
2003:
1954:
1891:
1842:
1777:
1728:
1709:
1692:
1668:
1651:
389:
168:
2624:
2594:
2555:
2516:
2487:
2277:
2201:
2090:
1677:
1636:
1316:
1311:
4845:
4840:
4835:
4830:
4717:
4556:
2931:
1985:
1873:
1791:
1719:
1399:
1159:
1140:
785:
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
2783:
825:
cell communication by electrical coupling involved in cardiac conduction
4825:
4191:
3559:
3527:
1488:
1379:
1340:
288:
185:
135:
2576:
2537:
2342:
2325:
76:
4910:
4820:
1014:
355:
342:
254:
241:
143:
2926:
2324:
Marks AR, Priori S, Memmi M, Kontula K, Laitinen PJ (January 2002).
2174:
Witcher DR, Kovacs RJ, Schulman H, Cefali DC, Jones LR (June 1991).
4923:
4271:
3250:
3245:
3240:
3235:
3167:
3162:
1395:
1300:
2563:
Awad SS, Lamb HK, Morgan JM, Dunlop W, Gillespie JI (March 1997).
2523:
2377:
2360:
1496:(dephosphorylation at serine positions S2808 and S2814 in rodents)
5050:
4807:
4643:
3144:
3139:
3134:
1649:
1383:
1336:
1126:
1081:
999:
995:
780:
regulation of cardiac muscle contraction by calcium ion signaling
1918:
123:
4727:
4722:
4456:
4451:
4397:
4392:
4208:
4196:
4186:
4181:
4169:
4164:
4159:
4046:
4041:
4036:
3928:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3769:
3764:
3754:
3749:
3744:
3695:
3690:
3680:
3675:
3552:
3547:
3542:
3537:
3443:
3438:
3433:
3423:
3418:
3408:
3403:
3333:
3328:
3323:
3318:
3221:
3216:
3211:
3206:
3194:
3189:
3184:
3179:
3088:
3055:
3050:
3045:
3040:
2834:
1476:
1472:
1468:
1406:
1403:
1284:
1036:
110:, ARVC2, ARVD2, RYR-2, RyR, VTSIP, ryanodine receptor 2, VACRDS
30:
2072:
935:
regulation of ventricular cardiac muscle cell action potential
835:
establishment of protein localization to endoplasmic reticulum
4961:
4892:
4887:
4882:
4799:
4786:
4781:
4776:
4771:
4766:
4761:
4712:
4705:
4700:
4695:
4690:
4685:
4680:
4675:
4670:
4658:
4653:
4648:
4638:
4633:
4628:
4623:
4538:
4482:
4439:
4434:
4429:
4424:
4419:
4414:
4409:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4338:
4333:
4328:
4323:
4311:
4228:
4223:
4218:
4203:
4141:
4136:
4131:
4122:
4117:
4103:
4098:
4089:
4084:
4079:
4070:
4065:
4056:
4051:
4018:
4013:
4008:
4003:
3994:
3985:
3980:
3975:
3966:
3961:
3956:
3951:
3942:
3937:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3759:
3729:
3724:
3719:
3714:
3685:
3634:
3629:
3624:
3619:
3609:
3604:
3584:
3569:
3564:
3479:
3474:
3469:
3464:
3448:
3428:
3413:
3374:
3369:
3364:
3359:
3267:
3262:
2985:
2980:
2975:
1855:
1464:
1410:
980:
Purkinje myocyte to ventricular cardiac muscle cell signaling
945:
calcium-mediated signaling using intracellular calcium source
2711:
2023:
5041:
5036:
5031:
5021:
5016:
5011:
5001:
4996:
4991:
4986:
4981:
4976:
4971:
4956:
4951:
4946:
4941:
4936:
4931:
4870:
4865:
4860:
4855:
4850:
4756:
4744:
4739:
4734:
4665:
4618:
4582:
4577:
4572:
4567:
4294:
4112:
3670:
3007:
2997:
2462:"Association of sorcin with the cardiac ryanodine receptor"
2252:"Association of sorcin with the cardiac ryanodine receptor"
2173:
1967:
1856:
Belevych AE, Radwański PB, Carnes CA, Györke S (May 2013).
1347:
3614:
3574:
2799:
2214:
1804:
970:
regulation of atrial cardiac muscle cell action potential
2674:
2601:
2494:
2294:
1608:
1479:,) (phosphorylation at serine position S2808 in rodents)
379:
2754:
2323:
1690:
1362:
The channel is composed of RYR2 homotetramers and
2459:
2249:
2639:
1431:
catecholaminergic polymorphic ventricular tachycardia
805:
positive regulation of the force of heart contraction
544:
2642:"Ryanodine receptors in human bladder smooth muscle"
2562:
850:
left ventricular cardiac muscle tissue morphogenesis
658:
ryanodine-sensitive calcium-release channel activity
2837:
2131:
1741:
2640:Chambers P, Neal DE, Gillespie JI (January 1999).
1906:"Entrez Gene: RYR2 ryanodine receptor 2 (cardiac)"
1552:
1550:
1548:
1531:
1529:
1527:
890:positive regulation of sequestering of calcium ion
800:regulation of cytosolic calcium ion concentration
326:
225:
5141:
5084:
2361:"Ryanodine receptors, FKBP12, and heart failure"
820:ventricular cardiac muscle cell action potential
2393:
2019:
2017:
2015:
2013:
1545:
1524:
765:release of sequestered calcium ion into cytosol
1557:GRCm38: Ensembl release 89: ENSMUSG00000021313
2912:
2120:
2118:
2066:
2010:
1961:
1849:
1735:
910:sarcoplasmic reticulum calcium ion transport
2422:
2243:
1684:
1536:GRCh38: Ensembl release 89: ENSG00000198626
940:regulation of AV node cell action potential
920:regulation of SA node cell action potential
643:protein kinase A regulatory subunit binding
16:Transport protein and coding gene in humans
2919:
2905:
1643:
1602:
1435:arrhythmogenic right ventricular dysplasia
704:junctional sarcoplasmic reticulum membrane
603:protein kinase A catalytic subunit binding
3503:
2948:
2889:at the U.S. National Library of Medicine
2817:
2782:
2772:
2729:
2657:
2584:
2545:
2477:
2376:
2341:
2267:
2191:
2150:
2115:
2098:
2041:
1993:
1944:
1881:
1832:
1822:
1767:
1718:
1708:
1667:
1626:
875:cellular response to epinephrine stimulus
2124:
1416:
965:type B pancreatic cell apoptotic process
930:regulation of cardiac muscle contraction
598:calcium-induced calcium release activity
5072:
3291:
1784:
1452:Ryanodine receptor 2 has been shown to
487:cardiac muscle tissue of left ventricle
5142:
1898:
5071:
4256:
3502:
3290:
2947:
2900:
2358:
429:cardiac muscle tissue of right atrium
331:
292:
287:
230:
189:
184:
4285:Calcium-activated chloride channels
2466:The Journal of Biological Chemistry
2256:The Journal of Biological Chemistry
2180:The Journal of Biological Chemistry
1811:The Journal of Biological Chemistry
1615:The Journal of Biological Chemistry
900:calcium ion transmembrane transport
13:
3355:Amiloride-sensitive cation channel
2659:10.1111/j.1469-445x.1999.tb00070.x
2287:
2229:10.1161/01.RES.0000125626.33738.E2
1343:. In humans, it is encoded by the
895:embryonic heart tube morphogenesis
880:multicellular organism development
770:calcium ion transport into cytosol
14:
5171:
4257:
2865:
2125:Huke S, Bers DM (November 2008).
860:positive regulation of heart rate
588:transmembrane transporter binding
2425:Cell Biochemistry and Biophysics
2408:10.1097/00001573-200205000-00002
830:cellular calcium ion homeostasis
775:regulation of cardiac conduction
653:calcium-release channel activity
315:
308:
302:
279:
214:
207:
201:
176:
29:
4878:Voltage-dependent anion channel
2971:Inositol trisphosphate receptor
2571:. 322 ( Pt 3) (Pt 3): 777–783.
2532:. 318 ( Pt 2) (Pt 2): 477–487.
2208:
2167:
1912:
1798:
1447:
1352:calcium-induced calcium release
915:canonical Wnt signaling pathway
719:sarcoplasmic reticulum membrane
608:organic cyclic compound binding
4900:General bacterial porin family
2330:Journal of Cellular Physiology
1584:
1566:
684:integral component of membrane
533:More reference expression data
457:right hemisphere of cerebellum
1:
2731:10.1016/S0092-8674(00)80847-8
2689:10.1016/S0304-3940(00)01046-6
2617:10.1016/S0306-4522(97)00612-X
2396:Current Opinion in Cardiology
2309:10.1016/S0065-227X(99)80004-5
2193:10.1016/S0021-9258(18)99140-4
2043:10.1016/S0092-8674(00)80847-8
1760:10.1161/CIRCRESAHA.110.219816
1628:10.1016/S0021-9258(18)77371-7
1518:
905:cellular response to caffeine
300:
199:
1937:10.1001/jamacardio.2019.5400
1357:
1350:. In the process of cardiac
1331:(RYR2) is one of a class of
739:cytoplasmic vesicle membrane
724:smooth endoplasmic reticulum
425:myocardium of left ventricle
7:
5160:EF-hand-containing proteins
5150:Genes on human chromosome 1
2079:The Journal of Cell Biology
1506:
1369:
950:response to muscle activity
885:ion transmembrane transport
10:
5176:
4319:Chloride Channel Accessory
2928:Membrane transport protein
2143:10.1016/j.bbrc.2008.08.084
1378:that supplies ions to the
960:calcium-mediated signaling
815:cardiac muscle hypertrophy
795:cardiac muscle contraction
760:response to muscle stretch
734:protein-containing complex
5125:
5080:
5067:
4908:
4797:
4593:
4491:
4467:
4269:
4265:
4252:
3875:
3780:
3645:
3518:
3514:
3498:
3385:
3344:
3314:Epithelial sodium channel
3306:
3302:
3286:
3018:
2963:
2959:
2943:
1592:"Mouse PubMed Reference:"
1574:"Human PubMed Reference:"
1429:gene are associated with
1315:
1310:
1306:
1299:
1283:
1270:Chr 1: 237.04 – 237.83 Mb
1264:
1249:
1245:
1228:
1224:
1217:
1202:
1198:
1181:
1177:
1170:
1157:
1153:
1138:
1134:
1125:
1112:
1108:
1093:
1089:
1080:
1067:
1063:
1048:
1044:
1035:
1020:
1013:
1009:
993:
628:identical protein binding
573:
569:
557:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
3231:Cation channels of sperm
2891:Medical Subject Headings
2819:10.1161/01.cir.103.2.196
2774:10.1161/01.cir.103.4.485
2497:Human Molecular Genetics
2479:10.1074/jbc.270.44.26411
2269:10.1074/jbc.270.44.26411
1697:Human Molecular Genetics
1277:Chr 13: 11.55 – 12.11 Mb
865:detection of calcium ion
855:regulation of heart rate
613:protein self-association
593:calcium channel activity
519:anterior amygdaloid area
2646:Experimental Physiology
2569:The Biochemical Journal
2530:The Biochemical Journal
2365:Frontiers in Bioscience
2359:Marks AR (April 2002).
1974:Cardiovascular Research
1862:Cardiovascular Research
1824:10.1074/jbc.M112.427062
1388:L-type calcium channels
985:transmembrane transport
870:response to redox state
689:calcium channel complex
495:interventricular septum
483:myocardium of ventricle
2849:10.1006/bbrc.2001.4444
2297:Advances in Biophysics
1669:10.1006/geno.1993.1357
1392:sarcoplasmic reticulum
1376:sarcoplasmic reticulum
1364:FK506-binding proteins
709:sarcoplasmic reticulum
648:protein kinase binding
507:lateral septal nucleus
503:atrioventricular valve
3307:Constitutively active
2509:10.1093/hmg/4.11.2151
2091:10.1083/jcb.153.4.699
1792:"Q92736 - RYR2_HUMAN"
1500:Protein phosphatase 2
1494:Protein phosphatase 1
1417:Clinical significance
955:calcium ion transport
845:BMP signaling pathway
453:primary visual cortex
333:13 A1|13 4.38 cM
294:Chromosome 13 (mouse)
2677:Neuroscience Letters
2437:10.1385/CBB:40:2:207
2217:Circulation Research
1748:Circulation Research
1710:10.1093/hmg/10.3.189
1329:Ryanodine receptor 2
925:response to caffeine
618:ion channel activity
515:primary motor cortex
192:Chromosome 1 (human)
69:List of PDB id codes
42:Available structures
5074:By gating mechanism
2887:RYR2+protein,+human
2472:(44): 26411–26418.
2262:(44): 26411–26418.
2186:(17): 11144–11152.
1817:(26): 18975–18986.
1621:(23): 13472–13483.
1339:found primarily in
1333:ryanodine receptors
790:response to hypoxia
663:calcium ion binding
4601:TRP cation channel
4499:CNG cation channel
3782:Tandem pore domain
2993:Ryanodine receptor
2371:(1–3): d970–d977.
1986:10.1093/cvr/cvs260
1874:10.1093/cvr/cvt024
1513:Ryanodine receptor
1115:ENSMUSG00000021313
753:Biological process
677:Cellular component
668:calmodulin binding
581:Molecular function
5137:
5136:
5121:
5120:
5117:
5116:
5109:Stretch-activated
5086:Ion channel class
5063:
5062:
5059:
5058:
4248:
4247:
4244:
4243:
3520:Calcium-activated
3508:Potassium channel
3494:
3493:
3490:
3489:
3282:
3281:
3278:
3277:
2577:10.1042/bj3220777
2538:10.1042/bj3180477
2503:(11): 2151–2154.
2343:10.1002/jcp.10031
1754:(11): 1743–1752.
1425:Mutations in the
1326:
1325:
1322:
1321:
1295:
1294:
1260:
1259:
1239:
1238:
1213:
1212:
1192:
1191:
1166:
1165:
1147:
1146:
1121:
1120:
1102:
1101:
1076:
1075:
1057:
1056:
1005:
1004:
565:
564:
561:
560:
539:
538:
526:
525:
464:
463:
362:
361:
261:
260:
88:
87:
84:
83:
52:Ortholog search:
5167:
5082:
5081:
5069:
5068:
4277:Chloride channel
4267:
4266:
4254:
4253:
3647:Inward-rectifier
3516:
3515:
3500:
3499:
3304:
3303:
3288:
3287:
3258:Two-pore channel
2961:
2960:
2945:
2944:
2921:
2914:
2907:
2898:
2897:
2860:
2831:
2821:
2796:
2786:
2776:
2751:
2733:
2708:
2671:
2661:
2636:
2598:
2588:
2559:
2549:
2520:
2491:
2481:
2456:
2419:
2390:
2380:
2355:
2345:
2320:
2282:
2281:
2271:
2247:
2241:
2240:
2212:
2206:
2205:
2195:
2171:
2165:
2164:
2154:
2122:
2113:
2112:
2102:
2070:
2064:
2063:
2045:
2021:
2008:
2007:
1997:
1965:
1959:
1958:
1948:
1916:
1910:
1909:
1902:
1896:
1895:
1885:
1853:
1847:
1846:
1836:
1826:
1802:
1796:
1795:
1788:
1782:
1781:
1771:
1739:
1733:
1732:
1722:
1712:
1688:
1682:
1681:
1671:
1647:
1641:
1640:
1630:
1606:
1600:
1599:
1588:
1582:
1581:
1570:
1564:
1554:
1543:
1533:
1461:Protein kinase A
1308:
1307:
1279:
1272:
1255:
1243:
1242:
1234:
1222:
1221:
1218:RefSeq (protein)
1208:
1196:
1195:
1187:
1175:
1174:
1151:
1150:
1132:
1131:
1106:
1105:
1087:
1086:
1061:
1060:
1042:
1041:
1011:
1010:
571:
570:
550:
549:
535:
475:
473:Top expressed in
468:
467:
445:Brodmann area 23
441:endothelial cell
413:
411:Top expressed in
406:
405:
385:
384:
368:
367:
358:
345:
334:
319:
312:
306:
295:
283:
267:
266:
257:
244:
233:
218:
211:
205:
194:
180:
164:
163:
158:
156:RYR2 - orthologs
109:
102:
79:
66:
65:
60:
39:
38:
33:
21:
20:
5175:
5174:
5170:
5169:
5168:
5166:
5165:
5164:
5140:
5139:
5138:
5133:
5113:
5076:
5055:
4904:
4803:
4793:
4589:
4487:
4463:
4261:
4240:
4154:
4031:
3888:
3871:
3776:
3740:
3710:
3666:
3658:
3641:
3595:
3510:
3486:
3459:
3398:
3381:
3340:
3298:
3274:
3157:
3129:
3116:
3103:
3083:
3070:
3035:
3014:
2955:
2953:Calcium channel
2939:
2925:
2868:
2863:
2290:
2288:Further reading
2285:
2248:
2244:
2213:
2209:
2172:
2168:
2123:
2116:
2071:
2067:
2022:
2011:
1966:
1962:
1925:JAMA Cardiology
1917:
1913:
1904:
1903:
1899:
1854:
1850:
1803:
1799:
1790:
1789:
1785:
1740:
1736:
1689:
1685:
1648:
1644:
1607:
1603:
1590:
1589:
1585:
1572:
1571:
1567:
1555:
1546:
1534:
1525:
1521:
1509:
1450:
1419:
1402:and allows the
1398:, which shifts
1372:
1360:
1317:View/Edit Mouse
1312:View/Edit Human
1275:
1268:
1265:Location (UCSC)
1251:
1230:
1204:
1183:
1096:ENSG00000198626
989:
748:
729:plasma membrane
672:
638:suramin binding
623:protein binding
531:
522:
517:
513:
509:
505:
501:
497:
493:
491:right ventricle
489:
485:
471:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
421:right ventricle
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
118:
105:
98:
75:
53:
17:
12:
11:
5:
5173:
5163:
5162:
5157:
5152:
5135:
5134:
5126:
5123:
5122:
5119:
5118:
5115:
5114:
5112:
5111:
5106:
5101:
5096:
5090:
5088:
5078:
5077:
5065:
5064:
5061:
5060:
5057:
5056:
5054:
5053:
5048:
5047:
5046:
5045:
5044:
5039:
5034:
5026:
5025:
5024:
5019:
5014:
5006:
5005:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4966:
4965:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4920:
4918:
4906:
4905:
4903:
4902:
4897:
4896:
4895:
4890:
4885:
4875:
4874:
4873:
4868:
4863:
4858:
4853:
4848:
4843:
4838:
4833:
4828:
4817:
4815:
4801:
4795:
4794:
4792:
4791:
4790:
4789:
4784:
4779:
4774:
4769:
4764:
4754:
4753:
4752:
4747:
4737:
4732:
4731:
4730:
4725:
4720:
4710:
4709:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4663:
4662:
4661:
4656:
4651:
4646:
4641:
4636:
4631:
4626:
4616:
4605:
4603:
4591:
4590:
4588:
4587:
4586:
4585:
4580:
4575:
4570:
4565:
4553:
4552:
4551:
4546:
4541:
4531:
4530:
4529:
4524:
4519:
4514:
4503:
4501:
4489:
4488:
4486:
4485:
4479:
4477:
4475:Proton channel
4465:
4464:
4462:
4461:
4460:
4459:
4454:
4444:
4443:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4402:
4401:
4400:
4395:
4390:
4385:
4380:
4375:
4370:
4365:
4360:
4350:
4345:
4344:
4343:
4342:
4341:
4336:
4331:
4326:
4316:
4315:
4314:
4309:
4299:
4298:
4297:
4281:
4279:
4263:
4262:
4250:
4249:
4246:
4245:
4242:
4241:
4239:
4238:
4233:
4232:
4231:
4226:
4221:
4211:
4206:
4201:
4200:
4199:
4194:
4189:
4184:
4174:
4173:
4172:
4167:
4162:
4152:
4147:
4146:
4145:
4144:
4139:
4134:
4127:
4126:
4125:
4120:
4115:
4108:
4107:
4106:
4101:
4094:
4093:
4092:
4087:
4082:
4075:
4074:
4073:
4068:
4061:
4060:
4059:
4054:
4049:
4044:
4039:
4029:
4024:
4023:
4022:
4021:
4016:
4011:
4006:
3999:
3998:
3997:
3990:
3989:
3988:
3983:
3978:
3971:
3970:
3969:
3964:
3959:
3954:
3947:
3946:
3945:
3940:
3933:
3932:
3931:
3926:
3921:
3916:
3911:
3906:
3901:
3896:
3886:
3881:
3879:
3873:
3872:
3870:
3869:
3868:
3867:
3862:
3857:
3852:
3847:
3842:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3786:
3784:
3778:
3777:
3775:
3774:
3773:
3772:
3767:
3762:
3757:
3752:
3747:
3738:
3734:
3733:
3732:
3727:
3722:
3717:
3708:
3700:
3699:
3698:
3693:
3688:
3683:
3678:
3673:
3664:
3660:
3656:
3651:
3649:
3643:
3642:
3640:
3639:
3638:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3593:
3589:
3588:
3587:
3579:
3578:
3577:
3572:
3567:
3557:
3556:
3555:
3550:
3545:
3540:
3535:
3524:
3522:
3512:
3511:
3496:
3495:
3492:
3491:
3488:
3487:
3485:
3484:
3483:
3482:
3477:
3472:
3467:
3457:
3453:
3452:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3396:
3391:
3389:
3383:
3382:
3380:
3379:
3378:
3377:
3372:
3367:
3362:
3351:
3349:
3342:
3341:
3339:
3338:
3337:
3336:
3331:
3326:
3321:
3310:
3308:
3300:
3299:
3296:Sodium channel
3284:
3283:
3280:
3279:
3276:
3275:
3273:
3272:
3271:
3270:
3265:
3255:
3254:
3253:
3248:
3243:
3238:
3227:
3226:
3225:
3224:
3219:
3214:
3209:
3199:
3198:
3197:
3192:
3187:
3182:
3172:
3171:
3170:
3165:
3155:
3150:
3149:
3148:
3147:
3142:
3137:
3127:
3119:
3114:
3106:
3101:
3093:
3092:
3091:
3081:
3073:
3068:
3060:
3059:
3058:
3053:
3048:
3043:
3033:
3024:
3022:
3016:
3015:
3013:
3012:
3011:
3010:
3005:
3000:
2990:
2989:
2988:
2983:
2978:
2967:
2965:
2957:
2956:
2941:
2940:
2924:
2923:
2916:
2909:
2901:
2895:
2894:
2884:
2879:
2874:
2867:
2866:External links
2864:
2862:
2861:
2843:(4): 979–986.
2832:
2812:(2): 196–200.
2797:
2767:(4): 485–490.
2752:
2724:(4): 365–376.
2709:
2672:
2637:
2611:(1): 205–216.
2599:
2560:
2521:
2492:
2457:
2431:(2): 207–224.
2420:
2402:(3): 218–221.
2391:
2356:
2321:
2291:
2289:
2286:
2284:
2283:
2242:
2223:(6): e61–e70.
2207:
2166:
2114:
2085:(4): 699–708.
2065:
2036:(4): 365–376.
2009:
1980:(3): 372–380.
1960:
1911:
1897:
1868:(2): 240–247.
1848:
1797:
1783:
1734:
1703:(3): 189–194.
1683:
1662:(2): 507–509.
1642:
1601:
1583:
1565:
1544:
1522:
1520:
1517:
1516:
1515:
1508:
1505:
1504:
1503:
1497:
1491:
1486:
1480:
1449:
1446:
1418:
1415:
1380:cardiac muscle
1371:
1368:
1359:
1356:
1341:cardiac muscle
1324:
1323:
1320:
1319:
1314:
1304:
1303:
1297:
1296:
1293:
1292:
1290:
1288:
1281:
1280:
1273:
1266:
1262:
1261:
1258:
1257:
1247:
1246:
1240:
1237:
1236:
1226:
1225:
1219:
1215:
1214:
1211:
1210:
1200:
1199:
1193:
1190:
1189:
1179:
1178:
1172:
1168:
1167:
1164:
1163:
1155:
1154:
1148:
1145:
1144:
1136:
1135:
1129:
1123:
1122:
1119:
1118:
1110:
1109:
1103:
1100:
1099:
1091:
1090:
1084:
1078:
1077:
1074:
1073:
1065:
1064:
1058:
1055:
1054:
1046:
1045:
1039:
1033:
1032:
1027:
1022:
1018:
1017:
1007:
1006:
1003:
1002:
991:
990:
988:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
756:
754:
750:
749:
747:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
680:
678:
674:
673:
671:
670:
665:
660:
655:
650:
645:
640:
635:
633:enzyme binding
630:
625:
620:
615:
610:
605:
600:
595:
590:
584:
582:
578:
577:
567:
566:
563:
562:
559:
558:
555:
554:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
5172:
5161:
5158:
5156:
5153:
5151:
5148:
5147:
5145:
5132:
5131:
5124:
5110:
5107:
5105:
5104:Voltage-gated
5102:
5100:
5097:
5095:
5092:
5091:
5089:
5087:
5083:
5079:
5075:
5070:
5066:
5052:
5049:
5043:
5040:
5038:
5035:
5033:
5030:
5029:
5027:
5023:
5020:
5018:
5015:
5013:
5010:
5009:
5007:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4969:
4967:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4929:
4927:
4926:
4925:
4922:
4921:
4919:
4917:
4914:
4912:
4907:
4901:
4898:
4894:
4891:
4889:
4886:
4884:
4881:
4880:
4879:
4876:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4823:
4822:
4819:
4818:
4816:
4814:
4811:
4809:
4805:
4796:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4759:
4758:
4755:
4751:
4748:
4746:
4743:
4742:
4741:
4738:
4736:
4733:
4729:
4726:
4724:
4721:
4719:
4716:
4715:
4714:
4711:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4668:
4667:
4664:
4660:
4657:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4635:
4632:
4630:
4627:
4625:
4622:
4621:
4620:
4617:
4614:
4610:
4607:
4606:
4604:
4602:
4599:
4597:
4592:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4560:
4559:
4558:
4554:
4550:
4547:
4545:
4542:
4540:
4537:
4536:
4535:
4532:
4528:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4509:
4508:
4505:
4504:
4502:
4500:
4497:
4495:
4490:
4484:
4481:
4480:
4478:
4476:
4473:
4471:
4466:
4458:
4455:
4453:
4450:
4449:
4448:
4445:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4407:
4406:
4403:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4355:
4354:
4351:
4349:
4346:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4321:
4320:
4317:
4313:
4310:
4308:
4305:
4304:
4303:
4300:
4296:
4293:
4292:
4291:
4288:
4287:
4286:
4283:
4282:
4280:
4278:
4275:
4273:
4268:
4264:
4260:
4259:Miscellaneous
4255:
4251:
4237:
4236:Shaker (gene)
4234:
4230:
4227:
4225:
4222:
4220:
4217:
4216:
4215:
4212:
4210:
4209:minK/ISK-like
4207:
4205:
4202:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4179:
4178:
4175:
4171:
4168:
4166:
4163:
4161:
4158:
4157:
4156:
4149:
4148:
4143:
4140:
4138:
4135:
4133:
4130:
4129:
4128:
4124:
4121:
4119:
4116:
4114:
4111:
4110:
4109:
4105:
4102:
4100:
4097:
4096:
4095:
4091:
4088:
4086:
4083:
4081:
4078:
4077:
4076:
4072:
4069:
4067:
4064:
4063:
4062:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4034:
4033:
4026:
4025:
4020:
4017:
4015:
4012:
4010:
4007:
4005:
4002:
4001:
4000:
3996:
3993:
3992:
3991:
3987:
3984:
3982:
3979:
3977:
3974:
3973:
3972:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3949:
3948:
3944:
3941:
3939:
3936:
3935:
3934:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3891:
3890:
3883:
3882:
3880:
3878:
3877:Voltage-gated
3874:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3792:
3791:
3788:
3787:
3785:
3783:
3779:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3742:
3741:
3735:
3731:
3728:
3726:
3723:
3721:
3718:
3716:
3713:
3712:
3711:
3704:
3701:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3672:
3669:
3668:
3667:
3661:
3659:
3653:
3652:
3650:
3648:
3644:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3597:
3596:
3590:
3586:
3583:
3582:
3580:
3576:
3573:
3571:
3568:
3566:
3563:
3562:
3561:
3558:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3530:
3529:
3526:
3525:
3523:
3521:
3517:
3513:
3509:
3506:
3501:
3497:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3462:
3461:
3454:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3401:
3400:
3393:
3392:
3390:
3388:
3387:Voltage-gated
3384:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3357:
3356:
3353:
3352:
3350:
3347:
3343:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3316:
3315:
3312:
3311:
3309:
3305:
3301:
3297:
3294:
3289:
3285:
3269:
3266:
3264:
3261:
3260:
3259:
3256:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3233:
3232:
3229:
3228:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3204:
3203:
3200:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3177:
3176:
3173:
3169:
3166:
3164:
3161:
3160:
3159:
3152:
3151:
3146:
3143:
3141:
3138:
3136:
3133:
3132:
3131:
3123:
3120:
3118:
3110:
3107:
3105:
3097:
3094:
3090:
3087:
3086:
3085:
3077:
3074:
3072:
3064:
3061:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3038:
3037:
3029:
3026:
3025:
3023:
3021:
3020:Voltage-gated
3017:
3009:
3006:
3004:
3001:
2999:
2996:
2995:
2994:
2991:
2987:
2984:
2982:
2979:
2977:
2974:
2973:
2972:
2969:
2968:
2966:
2962:
2958:
2954:
2951:
2946:
2942:
2937:
2933:
2929:
2922:
2917:
2915:
2910:
2908:
2903:
2902:
2899:
2892:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2869:
2858:
2854:
2850:
2846:
2842:
2838:
2833:
2829:
2825:
2820:
2815:
2811:
2807:
2803:
2798:
2794:
2790:
2785:
2780:
2775:
2770:
2766:
2762:
2758:
2753:
2749:
2745:
2741:
2737:
2732:
2727:
2723:
2719:
2715:
2710:
2706:
2702:
2698:
2694:
2690:
2686:
2682:
2678:
2673:
2669:
2665:
2660:
2655:
2651:
2647:
2643:
2638:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2606:
2600:
2596:
2592:
2587:
2582:
2578:
2574:
2570:
2566:
2561:
2557:
2553:
2548:
2543:
2539:
2535:
2531:
2527:
2522:
2518:
2514:
2510:
2506:
2502:
2498:
2493:
2489:
2485:
2480:
2475:
2471:
2467:
2463:
2458:
2454:
2450:
2446:
2442:
2438:
2434:
2430:
2426:
2421:
2417:
2413:
2409:
2405:
2401:
2397:
2392:
2388:
2384:
2379:
2378:10.2741/marks
2374:
2370:
2366:
2362:
2357:
2353:
2349:
2344:
2339:
2335:
2331:
2327:
2322:
2318:
2314:
2310:
2306:
2302:
2298:
2293:
2292:
2279:
2275:
2270:
2265:
2261:
2257:
2253:
2246:
2238:
2234:
2230:
2226:
2222:
2218:
2211:
2203:
2199:
2194:
2189:
2185:
2181:
2177:
2170:
2162:
2158:
2153:
2148:
2144:
2140:
2136:
2132:
2128:
2121:
2119:
2110:
2106:
2101:
2096:
2092:
2088:
2084:
2080:
2076:
2069:
2061:
2057:
2053:
2049:
2044:
2039:
2035:
2031:
2027:
2020:
2018:
2016:
2014:
2005:
2001:
1996:
1991:
1987:
1983:
1979:
1975:
1971:
1964:
1956:
1952:
1947:
1942:
1938:
1934:
1930:
1926:
1922:
1915:
1907:
1901:
1893:
1889:
1884:
1879:
1875:
1871:
1867:
1863:
1859:
1852:
1844:
1840:
1835:
1830:
1825:
1820:
1816:
1812:
1808:
1801:
1793:
1787:
1779:
1775:
1770:
1765:
1761:
1757:
1753:
1749:
1745:
1738:
1730:
1726:
1721:
1720:11577/2459215
1716:
1711:
1706:
1702:
1698:
1694:
1687:
1679:
1675:
1670:
1665:
1661:
1657:
1653:
1646:
1638:
1634:
1629:
1624:
1620:
1616:
1612:
1605:
1597:
1593:
1587:
1579:
1575:
1569:
1562:
1558:
1553:
1551:
1549:
1541:
1537:
1532:
1530:
1528:
1523:
1514:
1511:
1510:
1501:
1498:
1495:
1492:
1490:
1487:
1484:
1481:
1478:
1474:
1470:
1466:
1462:
1459:
1458:
1457:
1455:
1445:
1442:
1438:
1436:
1432:
1428:
1423:
1414:
1412:
1408:
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1377:
1367:
1365:
1355:
1353:
1349:
1346:
1342:
1338:
1334:
1330:
1318:
1313:
1309:
1305:
1302:
1298:
1291:
1289:
1286:
1282:
1278:
1274:
1271:
1267:
1263:
1256:
1254:
1248:
1244:
1241:
1235:
1233:
1227:
1223:
1220:
1216:
1209:
1207:
1201:
1197:
1194:
1188:
1186:
1180:
1176:
1173:
1171:RefSeq (mRNA)
1169:
1162:
1161:
1156:
1152:
1149:
1143:
1142:
1137:
1133:
1130:
1128:
1124:
1117:
1116:
1111:
1107:
1104:
1098:
1097:
1092:
1088:
1085:
1083:
1079:
1072:
1071:
1066:
1062:
1059:
1053:
1052:
1047:
1043:
1040:
1038:
1034:
1031:
1028:
1026:
1023:
1019:
1016:
1012:
1008:
1001:
997:
992:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
840:ion transport
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
757:
755:
752:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
681:
679:
676:
675:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
585:
583:
580:
579:
576:
575:Gene ontology
572:
568:
556:
551:
548:
546:
542:
534:
529:
518:
514:
511:dentate gyrus
510:
506:
502:
498:
494:
490:
486:
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
440:
437:right auricle
436:
433:apex of heart
432:
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
5155:Ion channels
5127:
5094:Ligand-gated
5085:
5073:
4916:Gap junction
4909:
4798:
4594:
4555:
4533:
4506:
4492:
4468:
4446:
4404:
4352:
4318:
4301:
4289:
4270:
4258:
4213:
4176:
4150:
4027:
3884:
3789:
3736:
3706:
3662:
3591:
3504:
3455:
3394:
3292:
3201:
3174:
3153:
3125:
3112:
3099:
3079:
3066:
3031:
3002:
2964:Ligand-gated
2949:
2932:ion channels
2840:
2836:
2809:
2805:
2784:11577/153951
2764:
2760:
2721:
2717:
2683:(1): 57–60.
2680:
2676:
2652:(1): 41–46.
2649:
2645:
2608:
2605:Neuroscience
2604:
2568:
2529:
2500:
2496:
2469:
2465:
2428:
2424:
2399:
2395:
2368:
2364:
2333:
2329:
2300:
2296:
2259:
2255:
2245:
2220:
2216:
2210:
2183:
2179:
2169:
2137:(1): 80–85.
2134:
2130:
2082:
2078:
2068:
2033:
2029:
1977:
1973:
1963:
1931:(3): 13–18.
1928:
1924:
1914:
1900:
1865:
1861:
1851:
1814:
1810:
1800:
1786:
1751:
1747:
1737:
1700:
1696:
1686:
1659:
1655:
1645:
1618:
1614:
1604:
1595:
1586:
1577:
1568:
1451:
1448:Interactions
1443:
1439:
1426:
1424:
1420:
1373:
1361:
1344:
1328:
1327:
1250:
1229:
1203:
1182:
1158:
1139:
1113:
1094:
1068:
1049:
1029:
1024:
395:
388:
253:237,833,988
240:237,042,184
115:External IDs
74:
18:
5099:Light-gated
3581:IK channel
2806:Circulation
2761:Circulation
1409:to bind to
1400:tropomyosin
354:12,106,945
341:11,553,102
93:Identifiers
5144:Categories
4302:Bestrophin
3560:SK channel
3528:BK channel
3202:γ-subunits
3175:β-subunits
3158:δ-subunits
2336:(1): 1–6.
1563:, May 2017
1542:, May 2017
1519:References
744:sarcolemma
714:Z discdkac
399:(ortholog)
136:HomoloGene
5130:disorders
5128:see also
4911:Cytoplasm
4821:Aquaporin
4290:Anoctamin
4113:11.1/hERG
2303:: 27–64.
1358:Structure
1253:NP_076357
1232:NP_001026
1206:NM_023868
1185:NM_001035
1015:Orthologs
699:sarcomere
449:vena cava
144:GeneCards
4924:Connexin
4204:minK/ISK
2857:11237759
2828:11208676
2793:11157710
2740:10830164
2705:32514035
2697:10788707
2668:10081705
2633:25634042
2453:25375622
2445:15054223
2416:12015469
2387:11897558
2352:11807805
2317:10463072
2237:15016728
2161:18755143
2109:11352932
2052:10830164
2004:22869620
1955:31913406
1892:23408344
1843:23678000
1778:20431056
1729:11159936
1656:Genomics
1559:–
1538:–
1507:See also
1454:interact
1396:troponin
1370:Function
1301:Wikidata
994:Sources:
694:membrane
5051:Innexin
4808:solutes
2748:6496567
2625:9607712
2595:9148749
2586:1218255
2556:8809036
2547:1217646
2517:8589694
2488:7592856
2278:7592856
2202:1645727
2152:2581610
2100:2192391
2060:6496567
1995:3500041
1946:6990654
1883:3633158
1834:3696672
1769:2895429
1678:8406504
1637:2380170
1561:Ensembl
1540:Ensembl
1384:systole
1382:during
1337:protein
1127:UniProt
1082:Ensembl
1021:Species
1000:QuickGO
374:pattern
100:Aliases
3348:-gated
3346:Proton
3122:T-type
3109:R-type
3096:Q-type
3076:P-type
3063:N-type
3028:L-type
2893:(MeSH)
2855:
2826:
2791:
2746:
2738:
2703:
2695:
2666:
2631:
2623:
2593:
2583:
2554:
2544:
2515:
2486:
2451:
2443:
2414:
2385:
2350:
2315:
2276:
2235:
2200:
2159:
2149:
2107:
2097:
2058:
2050:
2002:
1992:
1953:
1943:
1890:
1880:
1841:
1831:
1776:
1766:
1727:
1676:
1635:
1483:CaMKII
1477:PRKACG
1473:PRKACB
1469:PRKACA
1456:with:
1407:ATPase
1404:myosin
1335:and a
1287:search
1285:PubMed
1160:E9Q401
1141:Q92736
1037:Entrez
545:BioGPS
499:atrium
124:180902
4962:GJA10
4813:Porin
4713:TRPML
4483:HVCN1
4177:KCNIP
4032:α7-12
2936:TC 1A
2744:S2CID
2701:S2CID
2629:S2CID
2449:S2CID
2056:S2CID
1465:AKAP6
1411:actin
1070:20191
1030:Mouse
1025:Human
996:Amigo
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
140:37423
132:99685
5042:GJD4
5037:GJD3
5032:GJD2
5022:GJC3
5017:GJC2
5012:GJC1
5002:GJB7
4997:GJB6
4992:GJB5
4987:GJB4
4982:GJB3
4977:GJB2
4972:GJB1
4957:GJA9
4952:GJA8
4947:GJA5
4942:GJA4
4937:GJA3
4932:GJA1
4757:TRPV
4740:TRPP
4735:TRPN
4666:TRPM
4619:TRPC
4609:TRPA
4447:CLNS
4405:CLIC
4353:CLCN
4348:CFTR
4295:ANO1
4214:MiRP
4142:12.3
4137:12.2
4132:12.1
4123:11.3
4118:11.2
4104:10.2
4099:10.1
3889:α1-6
3703:GIRK
3117:α2.3
3104:α2.1
3071:α2.2
2853:PMID
2824:PMID
2789:PMID
2736:PMID
2718:Cell
2693:PMID
2664:PMID
2621:PMID
2591:PMID
2552:PMID
2513:PMID
2484:PMID
2441:PMID
2412:PMID
2383:PMID
2348:PMID
2313:PMID
2274:PMID
2233:PMID
2198:PMID
2157:PMID
2105:PMID
2048:PMID
2030:Cell
2000:PMID
1951:PMID
1888:PMID
1839:PMID
1774:PMID
1725:PMID
1674:PMID
1633:PMID
1433:and
1427:RYR2
1348:gene
1345:RYR2
1051:6262
380:Bgee
328:Band
289:Chr.
232:1q43
227:Band
186:Chr.
148:RYR2
120:OMIM
107:RYR2
77:4JKQ
58:RCSB
55:PDBe
24:RYR2
4806:(+
4644:4AP
4557:HCN
4090:9.3
4085:9.2
4080:9.1
4071:8.2
4066:8.1
4057:7.5
4052:7.4
4047:7.3
4042:7.2
4037:7.1
4019:6.4
4014:6.3
4009:6.2
4004:6.1
3995:5.1
3986:4.3
3981:4.2
3976:4.1
3967:3.4
3962:3.3
3957:3.2
3952:3.1
3943:2.2
3938:2.1
3929:1.8
3924:1.7
3919:1.6
3914:1.5
3909:1.4
3904:1.3
3899:1.2
3894:1.1
3790:K2P
3770:7.1
3765:6.2
3760:6.1
3755:5.1
3750:4.2
3745:4.1
3730:3.4
3725:3.3
3720:3.2
3715:3.1
3696:2.6
3691:2.4
3686:2.3
3681:2.2
3676:2.1
3671:1.1
3657:ATP
3635:5.1
3630:4.2
3625:4.1
3620:3.1
3615:2.3
3610:2.2
3605:2.1
3600:1.1
3585:IK1
3575:SK3
3570:SK2
3565:SK1
3444:1.9
3439:1.8
3434:1.7
3429:1.6
3424:1.5
3419:1.4
3414:1.3
3409:1.2
3404:1.1
3293:Na:
3145:3.3
3140:3.2
3135:3.1
3089:2.1
3056:1.4
3051:1.3
3046:1.2
3041:1.1
2950:Ca:
2845:doi
2841:281
2814:doi
2810:103
2779:hdl
2769:doi
2765:103
2726:doi
2722:101
2685:doi
2681:285
2654:doi
2613:doi
2581:PMC
2573:doi
2542:PMC
2534:doi
2505:doi
2474:doi
2470:270
2433:doi
2404:doi
2373:doi
2338:doi
2334:190
2305:doi
2264:doi
2260:270
2225:doi
2188:doi
2184:266
2147:PMC
2139:doi
2135:376
2095:PMC
2087:doi
2083:153
2038:doi
2034:101
1990:PMC
1982:doi
1941:PMC
1933:doi
1878:PMC
1870:doi
1829:PMC
1819:doi
1815:288
1764:PMC
1756:doi
1752:106
1715:hdl
1705:doi
1664:doi
1623:doi
1619:265
1489:SRI
553:n/a
350:End
249:End
152:OMA
128:MGI
48:PDB
5146::
5028:D
5008:C
4968:B
4928:A
4810:):
4563:FC
4457:1B
4452:1A
4440:L1
4398:KB
4393:KA
4272:Cl
3865:18
3860:17
3855:16
3850:15
3845:13
3840:12
3835:10
3739:ir
3709:ir
3665:ir
3594:Ca
3553:β4
3548:β3
3543:β2
3538:β1
3533:α1
3505:K:
3456:Na
3449:7A
3395:Na
3222:γ4
3217:γ3
3212:γ2
3207:γ1
3195:β4
3190:β3
3185:β2
3180:β1
3126:Ca
3113:Ca
3100:Ca
3080:Ca
3067:Ca
3032:Ca
2930::
2851:.
2839:.
2822:.
2808:.
2804:.
2787:.
2777:.
2763:.
2759:.
2742:.
2734:.
2720:.
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2648:.
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2609:85
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1471:,
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356:bp
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242:bp
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4826:0
4804:O
4802:2
4800:H
4787:6
4782:5
4777:4
4772:3
4767:2
4762:1
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4696:6
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4676:2
4671:1
4659:7
4654:6
4649:5
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4611:(
4598::
4596:M
4583:4
4578:3
4573:2
4568:1
4549:3
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4534:β
4527:4
4522:3
4517:2
4512:1
4507:α
4496::
4494:M
4472::
4470:H
4435:6
4430:5
4425:4
4420:3
4415:2
4410:1
4388:7
4383:6
4378:5
4373:4
4368:3
4363:2
4358:1
4339:4
4334:3
4329:2
4324:1
4312:2
4307:1
4274::
4229:3
4224:2
4219:1
4197:4
4192:3
4187:2
4182:1
4170:3
4165:2
4160:1
4155:β
4153:v
4151:K
4030:v
4028:K
3887:v
3885:K
3830:9
3825:7
3820:6
3815:5
3810:4
3805:3
3800:2
3795:1
3737:K
3707:K
3705:/
3663:K
3655:K
3592:K
3480:4
3475:3
3470:2
3465:1
3460:β
3458:v
3399:α
3397:v
3375:4
3370:3
3365:2
3360:1
3334:δ
3329:γ
3324:β
3319:α
3268:2
3263:1
3251:4
3246:3
3241:2
3236:1
3168:2
3163:1
3156:2
3154:α
3130:α
3128:v
3124:/
3115:v
3111:/
3102:v
3098:/
3084:α
3082:v
3078:/
3069:v
3065:/
3036:α
3034:v
3030:/
3008:3
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2998:1
2986:3
2981:2
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