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improved the reaction by changing the reaction conditions to higher temperatures and used no solvent for the reaction. Further improvement of the reaction was done in the following years, for example the use of
134:, not the nitrile, but Rosenmund speculated that the intermediate should be the nitrile, since nitriles on aromatic rings can react to form carboxylic acids. Independently
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207:"Das am Ringkohlenstoff gebundene Halogen und sein Ersatz durch andere Substituenten. I. Mitteilung: Ersatz des Halogens durch die Carboxylgruppe"
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Wu, Jeff Xin; Beck, Brandon; Ren, Rex X. (January 2002). "Catalytic
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who together with his Ph.D. student Erich Struck discovered in 1914 that aryl halide reacts with alcohol water solution of
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KOELSCH, C. F.; WHITNEY, A. G. (November 1941). "THE ROSENMUND-von BRAUN NITRILE SYNTHESIS".
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v. Braun, Julius; Manz, Gottfried (1931). "Fluoranthen und seine
Derivate. III. Mitteilung".
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E. Callen, Joseph; A. Dornfeld, Clinton; H. Coleman, George (1948). "9-CYANOPHENANTHRENE".
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Pongratz, Alfred (July 1927). "Untersuchungen über
Perylen und seine Derivate".
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Rosenmund, Karl W.; Struck, Erich (27 September 1919).
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a similar reaction for the synthesis of alkyl nitrile
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126:and catalytic amounts of
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172:Kolbe nitrile synthesis
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40:Substitution reaction
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