3507:
1210:
40:
1279:
is a type of ribonuclease that cleaves rRNA (16s rRNA and 23s rRNA) from transcribed polycistronic RNA operon in prokaryotes. It also digests double-stranded RNA (dsRNA)-Dicer family of RNAse, cutting pre-miRNA (60â70bp long) at a specific site and transforming it in miRNA (22â30bp), that is actively
1418:
is a ribonuclease of plant origin, which modulates SOS responses in bacteria, for a response to the stress of DNA damage by activation of the SOS mechanism by the RecA/LexA dependent signal transduction pathway that transcriptionally depresses a multiplicity of genes leading
1127:
Some cells also secrete copious quantities of non-specific RNases such as A and T1. RNases are, therefore, extremely common, resulting in very short lifespans for any RNA that is not in a protected environment. It is worth noting that all intracellular RNAs are protected from RNase activity by a
1119:
All organisms studied contain many RNases of two different classes, showing that RNA degradation is a very ancient and important process. As well as clearing of cellular RNA that is no longer required, RNases play key roles in the maturation of all RNA molecules, both messenger RNAs that carry
1594:
The active site looks like a rift valley where all the active site residues create the wall and bottom of the valley. The rift is very thin and the small substrate fits perfectly in the middle of the active site, which allows for perfect interaction with the residues. It actually has a little
1120:
genetic material for making proteins and non-coding RNAs that function in varied cellular processes. In addition, active RNA degradation systems are the first defense against RNA viruses and provide the underlying machinery for more advanced cellular immune strategies such as
1327:). In bacteria RNase P is also responsible for the catalytic activity of holoenzymes, which consist of an apoenzyme that forms an active enzyme system by combination with a coenzyme and determines the specificity of this system for a substrate. A form of RNase P that is a
1263:
is a ribonuclease that cleaves the RNA in a DNA/RNA duplex to produce ssDNA. RNase H is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism, aided by an enzyme-bound divalent metal ion. RNase H leaves a 5'-phosphorylated
1434:
It is involved in processing the 16'-end of the 5s rRNA. It is related to chromosome separation and cell division. It is considered one of the components of cytoplasmic axial filament bundles. It is also thought that it can regulate the formation of this
1248:. It is specific for single-stranded RNAs. It cleaves the 3'-end of unpaired C and U residues, ultimately forming a 3'-phosphorylated product via a 2',3'-cyclic monophosphate intermediate. It does not require any cofactors for its activity
1616:. In addition to the cellular RNases that are released, there are several RNases that are present in the environment. RNases have evolved to have many extracellular functions in various organisms. For example, RNase 7, a member of the
1611:
in molecular biology experiments is greatly complicated by the presence of ubiquitous and hardy ribonucleases that degrade RNA samples. Certain RNases can be extremely hardy and inactivating them is difficult compared to neutralizing
1941:
Wachi M, Umitsuki G, Shimizu M, Takada A, Nagai K. Escherichia coli cafA gene encodes a novel RNase, designated as RNase G, involved in processing of the 5' end of 16S rRNA. Biochem
Biophys Res Commun. 1999;259(2):483â488.
1158:
for the RI-RNase A complex is ~20 fM under physiological conditions. RI is used in most laboratories that study RNA to protect their samples against degradation from environmental RNases.
1932:
Shamsher S. Kanwar*, Puranjan Mishra, Khem Raj Meena, Shruti Gupta and Rakesh Kumar, Ribonucleases and their
Applications, 2016, Journal of Advanced Biotechnology and Bioengineering
1640:
Noguchi S (July 2010). "Isomerization mechanism of aspartate to sexxxxxxxx implied by structures of
Ustilago sphaerogena ribonuclease U2 complexed with adenosine 3'-monophosphate".
1620:
superfamily, is secreted by human skin and serves as a potent antipathogen defence. In these secreted RNases, the enzymatic RNase activity may not even be necessary for its new,
1244:) is one of the hardiest enzymes in common laboratory usage; one method of isolating it is to boil a crude cellular extract until all enzymes other than RNase A are
2988:
1150:, which comprises a relatively large fraction of cellular protein (~0.1%) in some cell types, and which binds to certain ribonucleases with the highest affinity of any
2934:
2326:
Ahmed TAE, Udenigwe CC, Gomaa A. Editorial: Biotechnology and
Bioengineering Applications for Egg-Derived Biomaterials. Front Bioeng Biotechnol. 2021 Sep 20;9:756058
147:
1731:"Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution"
2596:
1111:, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.
2757:
2414:
1595:
curvature to the site which the substrate also has. Although usually most exo- and endoribonucleases are not sequence specific, recently
2853:
2242:"The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity"
1506:
is a close homolog of RNase II, but it can, unlike RNase II, degrade RNA with secondary structures without help of accessory factors.
2564:
2581:
2828:
1713:
1686:
1456:
95:
1995:"A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformis"
167:
2742:
2843:
2837:
2638:
2388:
1829:
2686:
1952:
Tamulaitis G, Kazlauskiene M, Manakova E, Venclovas Ä, Nwokeoji AO, Dickman MJ, Horvath P, Siksnys V (November 2014).
3226:
2797:
2586:
1894:"RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme"
1373:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of all 4 residues, but preferentially 3'-end of As.
2904:
2792:
2713:
2623:
2576:
1599:/Cas system natively recognizing and cutting DNA was engineered to cleave ssRNA in a sequence-specific manner.
155:
3382:
3135:
3076:
3180:
2747:
2737:
3140:
3032:
2657:
2342:
Gerdes K, Christensen SK and Lobner-Olesen A (2005). "Prokaryotic toxin-antitoxin stress response loci".
1245:
1151:
3497:
2726:
2722:
2718:
2634:
2467:
151:
3483:
3470:
3457:
3444:
3431:
3418:
3405:
3367:
2894:
2450:
108:
3377:
3331:
3274:
2642:
2491:
2405:
1573:
1558:
1543:
1531:
1512:
1509:
1497:
1474:
1471:
1448:
1445:
1422:
1406:
1391:
1376:
1361:
1346:
1334:
1295:
1283:
1267:
1251:
1218:
1173:
that recognize and cleave specific sequences of single-stranded RNA have been recently classified.
3279:
2511:
2381:
3527:
3067:
2706:
1491:
1465:
1189:
1145:
1954:"Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus"
1703:
1676:
1343:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of unpaired A and U residues.
1319:. One of its functions is to cleave off a leader sequence from the 5' end of one stranded pre-
3300:
3219:
3002:
2899:
2691:
2652:
2516:
2438:
2240:
Huang YC, Lin YM, Chang TW, Wu SJ, Lee YS, Chang MD, Chen C, Wu SH, Liao YD (February 2007).
1155:
17:
2361:
3372:
3185:
3020:
3015:
2948:
2608:
2433:
2194:
1181:
134:
1624:
function. For example, immune RNases act by destabilizing the cell membranes of bacteria.
8:
3336:
3040:
3010:
2814:
2809:
2733:
2669:
2455:
1323:. RNase P is one of two known multiple turnover ribozymes in nature (the other being the
1292:
is an interferon-induced nuclease that, upon activation, destroys all RNA within the cell
2198:
1388:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of unpaired A residues.
1358:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of unpaired G residues.
3542:
3537:
3269:
3173:
3025:
2506:
2496:
2374:
2307:
2282:
2217:
2182:
2122:
2070:
2045:
2021:
1994:
1869:
1844:
1806:
1782:"Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism"
1781:
1757:
1730:
1581:
1193:
1162:
2974:
2919:
2887:
2762:
2481:
2312:
2263:
2222:
2163:
2114:
2075:
2026:
1975:
1915:
1874:
1811:
1762:
1709:
1682:
1657:
1566:
1551:
1236:
1137:
174:
142:
100:
2142:"RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin"
2126:
76:
3315:
3310:
3284:
3212:
3050:
2630:
2535:
2530:
2486:
2302:
2294:
2253:
2212:
2202:
2153:
2106:
2065:
2057:
2016:
2006:
1965:
1905:
1892:
Holzmann J, Frank P, Löffler E, Bennett KL, Gerner C, Rossmanith W (October 2008).
1864:
1856:
1801:
1793:
1752:
1742:
1649:
1419:
to transit arrest of cell division as well as initiation of DNA repair.
1170:
1104:
130:
3532:
3362:
3346:
3259:
3152:
2966:
2882:
2877:
2872:
2785:
2780:
2540:
2418:
2356:
2207:
1970:
1953:
1747:
1185:
1133:
1108:
88:
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3400:
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3125:
3120:
3115:
2501:
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2428:
2061:
1910:
1893:
1608:
1226:
2181:
Köten B, Simanski M, GlÀser R, Podschun R, Schröder JM, Harder J (July 2009).
2110:
1653:
3521:
3305:
3264:
2866:
2775:
2525:
1136:, formation of an RNA·RNA duplex, and folding within an RNA protein complex (
49:
3254:
2993:
2647:
2568:
2316:
2267:
2258:
2241:
2226:
2183:"RNase 7 contributes to the cutaneous defense against Enterococcus faecium"
2167:
2158:
2141:
2118:
2079:
2030:
2011:
1979:
1919:
1878:
1860:
1815:
1766:
1661:
1525:
1177:
2095:"The RNase a superfamily: generation of diversity and innate host defense"
104:
3478:
3413:
3249:
3168:
2939:
2833:
2696:
2662:
2600:
1540:
is the major contributor for the 3'-to-5' maturation of many stable RNAs.
1487:
1461:
1409:
2298:
1576:
1561:
1546:
1515:
1477:
1425:
1394:
1379:
1364:
1349:
1298:
1270:
1254:
1221:
3145:
1951:
1621:
1451:
1339:
1797:
1570:
degrades single-stranded RNA from 5'-to-3', exists only in eukaryotes.
1240:
3452:
3426:
3058:
2857:
2770:
2397:
1275:
1129:
1096:
2094:
1176:
RNases play a critical role in many biological processes, including
1070:
1064:
1057:
1051:
1045:
1039:
1033:
1027:
1021:
1015:
1009:
1003:
997:
991:
985:
979:
973:
967:
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949:
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919:
913:
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865:
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835:
829:
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811:
805:
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769:
763:
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739:
733:
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709:
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673:
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655:
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631:
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619:
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583:
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559:
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547:
541:
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529:
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517:
511:
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367:
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349:
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337:
331:
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307:
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277:
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265:
259:
253:
247:
241:
235:
229:
223:
217:
211:
205:
199:
192:
186:
180:
3506:
3103:
3098:
3093:
2914:
2549:
2401:
1482:
1384:
1369:
1354:
1324:
1308:
1092:
83:
3110:
3088:
3083:
2701:
1617:
1536:
1520:
1502:
1430:
1414:
1399:
1328:
1303:
1288:
1259:
3465:
3235:
3130:
3063:
2956:
2554:
2462:
1596:
1316:
1280:
involved in the regulation of transcription and mRNA life-time.
162:
1845:"Retroviral integrase superfamily: the structural perspective"
3439:
3072:
2823:
2819:
2046:"T2 Family ribonucleases: ancient enzymes with diverse roles"
1613:
1602:
1165:, which cleave highly specific sequences of double-stranded
1103:
into smaller components. Ribonucleases can be divided into
2804:
2681:
2674:
2618:
2613:
2283:"RNase A ribonucleases and host defense: an evolving story"
2180:
1891:
1320:
1188:(angiosperms). Many stress-response toxins of prokaryotic
1121:
124:
71:
3204:
1945:
1209:
1312:
1307:
is a type of ribonuclease that is unique in that it is a
1166:
1100:
1230:
is an RNase that is commonly used in research. RNase A (
39:
1708:. Springer Science & Business Media. p. 237.
1681:. Springer Science & Business Media. p. 556.
1331:
and does not contain RNA has recently been discovered.
3495:
27:
Class of enzyme that catalyzes the degradation of RNA
1992:
1780:
Cuchillo CM, Nogués MV, Raines RT (September 2011).
1779:
1555:
degrades short oligonucleotides to mononucleotides.
1204:
1722:
1439:
2692:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
2396:
1728:
3519:
1729:Ramage HR, Connolly LE, Cox JS (December 2009).
1403:is specific for polyadenine and polyuridine RNA.
2239:
1668:
2139:
1993:Rossier O, Dao J, Cianciotto NP (March 2009).
1524:is involved in the 3'-to-5' processing of pre-
1315:that acts as a catalyst in the same way as an
3220:
2382:
2092:
2043:
1678:Peptide Growth Factors and Their Receptors II
1674:
1695:
1192:have been shown to have RNase activity and
3227:
3213:
2389:
2375:
1836:
1633:
38:
2306:
2280:
2257:
2216:
2206:
2157:
2069:
2020:
2010:
1969:
1909:
1868:
1805:
1756:
1746:
1705:Developmental Biology of Flowering Plants
1603:RNase contamination during RNA extraction
2335:D'Alessio G and Riordan JF, eds. (1997)
1701:
1675:Sporn MB, Roberts AB (6 December 2012).
1585:is a close homolog of Exoribonuclease I.
1208:
2582:Ubiquitin carboxy-terminal hydrolase L1
2337:Ribonucleases: Structures and Functions
2140:Harder J, Schroder JM (November 2002).
2093:Dyer KD, Rosenberg HF (November 2006).
1842:
1639:
14:
3520:
3208:
3162:either deoxy- or ribo-
2370:
2362:Integrated Enzyme Database for EC 3.1
1457:Polynucleotide Phosphorylase (PNPase)
2743:Protein serine/threonine phosphatase
1589:
1234:, bovine pancreatic ribonuclease A:
2844:Cyclic nucleotide phosphodiesterase
2838:Clostridium perfringens alpha toxin
2639:Tartrate-resistant acid phosphatase
2246:The Journal of Biological Chemistry
2146:The Journal of Biological Chemistry
1143:Another mechanism of protection is
47:Ribonuclease U2 with AMP PDB entry
24:
2687:Pyruvate dehydrogenase phosphatase
25:
3554:
2587:4-hydroxybenzoyl-CoA thioesterase
2350:
1199:
3505:
2357:IUBMB Enzyme Database for EC 3.1
2044:Luhtala N, Parker R (May 2010).
1205:Major types of endoribonucleases
2905:N-acetylglucosamine-6-sulfatase
2793:Sphingomyelin phosphodiesterase
2274:
2233:
2174:
2133:
2086:
2037:
1986:
1935:
1440:Major types of exoribonucleases
1128:number of strategies including
2714:Inositol-phosphate phosphatase
2577:Palmitoyl protein thioesterase
2050:Trends in Biochemical Sciences
1926:
1885:
1822:
1773:
1702:Raghavan V (6 December 2012).
13:
1:
3077:RNA-induced silencing complex
1627:
119:Available protein structures:
3181:Serratia marcescens nuclease
2748:Dual-specificity phosphatase
2738:Protein tyrosine phosphatase
2287:Journal of Leukocyte Biology
2208:10.1371/journal.pone.0006424
1971:10.1016/j.molcel.2014.09.027
1748:10.1371/journal.pgen.1000767
7:
3234:
2658:Fructose 1,6-bisphosphatase
1843:Nowotny M (February 2009).
1152:protein-protein interaction
1114:
10:
3559:
2329:
2062:10.1016/j.tibs.2010.02.002
1942:doi:10.1006/bbrc.1999.0806
1911:10.1016/j.cell.2008.09.013
1830:"Library Preparation Kits"
3391:
3383:MichaelisâMenten kinetics
3355:
3324:
3293:
3242:
3161:
3049:
3001:
2987:
2965:
2947:
2933:
2913:
2895:Galactosamine-6 sulfatase
2852:
2756:
2595:
2563:
2451:6-phosphogluconolactonase
2413:
2281:Rosenberg HF (May 2008).
2111:10.1007/s11030-006-9028-2
1654:10.1107/S0907444910019621
173:
161:
141:
123:
118:
114:
94:
82:
70:
62:
57:
37:
32:
3275:Diffusion-limited enzyme
2643:Purple acid phosphatases
1642:Acta Crystallographica D
1190:toxin-antitoxin systems
3068:Microprocessor complex
2707:Beta-propeller phytase
2259:10.1074/jbc.M607321200
2159:10.1074/jbc.M207587200
2012:10.1099/mic.0.023218-0
1861:10.1038/embor.2008.256
1492:nucleotidyltransferase
1466:nucleotidyltransferase
1214:
1146:ribonuclease inhibitor
1087:(commonly abbreviated
3368:EadieâHofstee diagram
3301:Allosteric regulation
3003:Endodeoxyribonuclease
2900:Iduronate-2-sulfatase
2653:Glucose 6-phosphatase
2439:Butyrylcholinesterase
1212:
1156:dissociation constant
3378:LineweaverâBurk plot
3186:Micrococcal nuclease
3021:Deoxyribonuclease IV
3016:Deoxyribonuclease II
2949:Exodeoxyribonuclease
2609:Alkaline phosphatase
2434:Acetylcholinesterase
2344:Nat. Rev. Microbiol.
1213:Structure of RNase A
1182:self-incompatibility
45:Ustilago sphaerogena
3041:UvrABC endonuclease
3011:Deoxyribonuclease I
2734:Protein phosphatase
2670:Protein phosphatase
2468:Bile salt-dependent
2456:PAF acetylhydrolase
2299:10.1189/jlb.1107725
2199:2009PLoSO...4.6424K
2099:Molecular Diversity
1163:restriction enzymes
1099:the degradation of
3337:Enzyme superfamily
3270:Enzyme promiscuity
3174:Mung bean nuclease
3033:Restriction enzyme
3026:Restriction enzyme
1582:Exoribonuclease II
1215:
1140:particle or RNP).
3493:
3492:
3202:
3201:
3198:
3197:
3194:
3193:
2983:
2982:
2975:Oligonucleotidase
2920:deoxyribonuclease
2888:Steroid sulfatase
2763:Phosphodiesterase
2492:Hormone-sensitive
2339:, Academic Press.
1798:10.1021/bi201075b
1715:978-1-4612-1234-8
1688:978-3-642-74781-6
1609:extraction of RNA
1590:RNase specificity
1567:Exoribonuclease I
1552:Oligoribonuclease
1171:endoribonucleases
1138:ribonucleoprotein
1105:endoribonucleases
1082:
1081:
1078:
1077:
168:structure summary
16:(Redirected from
3550:
3510:
3509:
3501:
3373:HanesâWoolf plot
3316:Enzyme activator
3311:Enzyme inhibitor
3285:Enzyme catalysis
3229:
3222:
3215:
3206:
3205:
3051:Endoribonuclease
3037:
3031:
2999:
2998:
2945:
2944:
2931:
2930:
2631:Acid phosphatase
2512:Monoacylglycerol
2422:ester hydrolases
2391:
2384:
2377:
2368:
2367:
2321:
2320:
2310:
2278:
2272:
2271:
2261:
2237:
2231:
2230:
2220:
2210:
2178:
2172:
2171:
2161:
2152:(48): 46779â84.
2137:
2131:
2130:
2090:
2084:
2083:
2073:
2041:
2035:
2034:
2024:
2014:
2005:(Pt 3): 882â90.
1990:
1984:
1983:
1973:
1949:
1943:
1939:
1933:
1930:
1924:
1923:
1913:
1889:
1883:
1882:
1872:
1840:
1834:
1833:
1826:
1820:
1819:
1809:
1777:
1771:
1770:
1760:
1750:
1741:(12): e1000767.
1726:
1720:
1719:
1699:
1693:
1692:
1672:
1666:
1665:
1637:
1486:functions as an
1460:functions as an
1313:ribonucleic acid
1243:
1186:flowering plants
1109:exoribonucleases
1073:
1067:
1060:
1054:
1048:
1042:
1036:
1030:
1024:
1018:
1012:
1006:
1000:
994:
988:
982:
976:
970:
964:
958:
952:
946:
940:
934:
928:
922:
916:
910:
904:
898:
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886:
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874:
868:
862:
856:
850:
844:
838:
832:
826:
820:
814:
808:
802:
796:
790:
784:
778:
772:
766:
760:
754:
748:
742:
736:
730:
724:
718:
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706:
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682:
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664:
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598:
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520:
514:
508:
502:
496:
490:
484:
478:
472:
466:
460:
454:
448:
442:
436:
430:
424:
418:
412:
406:
400:
394:
388:
382:
376:
370:
364:
358:
352:
346:
340:
334:
328:
322:
316:
310:
304:
298:
292:
286:
280:
274:
268:
262:
256:
250:
244:
238:
232:
226:
220:
214:
208:
202:
195:
189:
183:
116:
115:
52:
42:
30:
29:
21:
3558:
3557:
3553:
3552:
3551:
3549:
3548:
3547:
3518:
3517:
3516:
3504:
3496:
3494:
3489:
3401:Oxidoreductases
3387:
3363:Enzyme kinetics
3351:
3347:List of enzymes
3320:
3289:
3260:Catalytic triad
3238:
3233:
3203:
3190:
3157:
3045:
3035:
3029:
2992:
2979:
2967:Exoribonuclease
2961:
2938:
2922:
2918:
2909:
2883:Arylsulfatase L
2878:Arylsulfatase B
2873:Arylsulfatase A
2848:
2761:
2752:
2591:
2559:
2421:
2409:
2395:
2353:
2332:
2324:
2279:
2275:
2238:
2234:
2179:
2175:
2138:
2134:
2091:
2087:
2042:
2038:
1991:
1987:
1950:
1946:
1940:
1936:
1931:
1927:
1890:
1886:
1841:
1837:
1828:
1827:
1823:
1792:(37): 7835â41.
1778:
1774:
1727:
1723:
1716:
1700:
1696:
1689:
1673:
1669:
1648:(Pt 7): 843â9.
1638:
1634:
1630:
1605:
1592:
1442:
1235:
1207:
1202:
1169:, a variety of
1134:polyadenylation
1117:
1091:) is a type of
1069:
1063:
1056:
1050:
1044:
1038:
1032:
1026:
1020:
1014:
1008:
1002:
996:
990:
984:
978:
972:
966:
960:
954:
948:
942:
936:
930:
924:
918:
912:
906:
900:
894:
888:
882:
876:
870:
864:
858:
852:
846:
840:
834:
828:
822:
816:
810:
804:
798:
792:
786:
780:
774:
768:
762:
756:
750:
744:
738:
732:
726:
720:
714:
708:
702:
696:
690:
684:
678:
672:
666:
660:
654:
648:
642:
636:
630:
624:
618:
612:
606:
600:
594:
588:
582:
576:
570:
564:
558:
552:
546:
540:
534:
528:
522:
516:
510:
504:
498:
492:
486:
480:
474:
468:
462:
456:
450:
444:
438:
432:
426:
420:
414:
408:
402:
396:
390:
384:
378:
372:
366:
360:
354:
348:
342:
336:
330:
324:
318:
312:
306:
300:
294:
288:
282:
276:
270:
264:
258:
252:
246:
240:
234:
228:
222:
216:
210:
204:
198:
191:
185:
179:
53:
48:
28:
23:
22:
15:
12:
11:
5:
3556:
3546:
3545:
3540:
3535:
3530:
3515:
3514:
3491:
3490:
3488:
3487:
3474:
3461:
3448:
3435:
3422:
3409:
3395:
3393:
3389:
3388:
3386:
3385:
3380:
3375:
3370:
3365:
3359:
3357:
3353:
3352:
3350:
3349:
3344:
3339:
3334:
3328:
3326:
3325:Classification
3322:
3321:
3319:
3318:
3313:
3308:
3303:
3297:
3295:
3291:
3290:
3288:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3246:
3244:
3240:
3239:
3232:
3231:
3224:
3217:
3209:
3200:
3199:
3196:
3195:
3192:
3191:
3189:
3188:
3183:
3178:
3177:
3176:
3165:
3163:
3159:
3158:
3156:
3155:
3150:
3149:
3148:
3143:
3138:
3133:
3123:
3118:
3113:
3108:
3107:
3106:
3101:
3096:
3091:
3081:
3080:
3079:
3070:
3055:
3053:
3047:
3046:
3044:
3043:
3038:
3023:
3018:
3013:
3007:
3005:
2996:
2985:
2984:
2981:
2980:
2978:
2977:
2971:
2969:
2963:
2962:
2960:
2959:
2953:
2951:
2942:
2928:
2911:
2910:
2908:
2907:
2902:
2897:
2892:
2891:
2890:
2885:
2880:
2875:
2862:
2860:
2850:
2849:
2847:
2846:
2841:
2831:
2826:
2817:
2812:
2807:
2802:
2801:
2800:
2790:
2789:
2788:
2783:
2773:
2767:
2765:
2754:
2753:
2751:
2750:
2745:
2740:
2731:
2730:
2729:
2711:
2710:
2709:
2699:
2694:
2689:
2684:
2679:
2678:
2677:
2667:
2666:
2665:
2655:
2650:
2645:
2628:
2627:
2626:
2621:
2616:
2605:
2603:
2593:
2592:
2590:
2589:
2584:
2579:
2573:
2571:
2561:
2560:
2558:
2557:
2552:
2546:
2545:
2544:
2543:
2538:
2533:
2522:
2521:
2520:
2519:
2517:Diacylglycerol
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2479:
2470:
2459:
2458:
2453:
2448:
2446:Pectinesterase
2443:
2442:
2441:
2436:
2429:Cholinesterase
2425:
2423:
2411:
2410:
2394:
2393:
2386:
2379:
2371:
2365:
2364:
2359:
2352:
2351:External links
2349:
2348:
2347:
2340:
2331:
2328:
2323:
2322:
2293:(5): 1079â87.
2273:
2252:(7): 4626â33.
2232:
2173:
2132:
2085:
2036:
1985:
1958:Molecular Cell
1944:
1934:
1925:
1884:
1835:
1821:
1772:
1721:
1714:
1694:
1687:
1667:
1631:
1629:
1626:
1604:
1601:
1591:
1588:
1587:
1586:
1571:
1556:
1541:
1529:
1507:
1495:
1469:
1441:
1438:
1437:
1436:
1420:
1404:
1389:
1374:
1359:
1344:
1332:
1293:
1281:
1265:
1249:
1206:
1203:
1201:
1200:Classification
1198:
1130:5' end capping
1116:
1113:
1080:
1079:
1076:
1075:
177:
171:
170:
165:
159:
158:
145:
139:
138:
128:
121:
120:
112:
111:
98:
92:
91:
86:
80:
79:
74:
68:
67:
64:
60:
59:
55:
54:
43:
35:
34:
26:
9:
6:
4:
3:
2:
3555:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3528:Ribonucleases
3526:
3525:
3523:
3513:
3508:
3503:
3502:
3499:
3485:
3481:
3480:
3475:
3472:
3468:
3467:
3462:
3459:
3455:
3454:
3449:
3446:
3442:
3441:
3436:
3433:
3429:
3428:
3423:
3420:
3416:
3415:
3410:
3407:
3403:
3402:
3397:
3396:
3394:
3390:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3360:
3358:
3354:
3348:
3345:
3343:
3342:Enzyme family
3340:
3338:
3335:
3333:
3330:
3329:
3327:
3323:
3317:
3314:
3312:
3309:
3307:
3306:Cooperativity
3304:
3302:
3299:
3298:
3296:
3292:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3265:Oxyanion hole
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3247:
3245:
3241:
3237:
3230:
3225:
3223:
3218:
3216:
3211:
3210:
3207:
3187:
3184:
3182:
3179:
3175:
3172:
3171:
3170:
3167:
3166:
3164:
3160:
3154:
3151:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3128:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3086:
3085:
3082:
3078:
3074:
3071:
3069:
3065:
3062:
3061:
3060:
3057:
3056:
3054:
3052:
3048:
3042:
3039:
3034:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3008:
3006:
3004:
3000:
2997:
2995:
2990:
2986:
2976:
2973:
2972:
2970:
2968:
2964:
2958:
2955:
2954:
2952:
2950:
2946:
2943:
2941:
2936:
2932:
2929:
2926:
2921:
2916:
2912:
2906:
2903:
2901:
2898:
2896:
2893:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2870:
2869:
2868:
2867:arylsulfatase
2864:
2863:
2861:
2859:
2855:
2851:
2845:
2842:
2839:
2835:
2832:
2830:
2827:
2825:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2799:
2796:
2795:
2794:
2791:
2787:
2784:
2782:
2779:
2778:
2777:
2776:Phospholipase
2774:
2772:
2769:
2768:
2766:
2764:
2759:
2755:
2749:
2746:
2744:
2741:
2739:
2735:
2732:
2728:
2724:
2720:
2717:
2716:
2715:
2712:
2708:
2705:
2704:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2676:
2673:
2672:
2671:
2668:
2664:
2661:
2660:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2640:
2636:
2632:
2629:
2625:
2622:
2620:
2617:
2615:
2612:
2611:
2610:
2607:
2606:
2604:
2602:
2598:
2594:
2588:
2585:
2583:
2580:
2578:
2575:
2574:
2572:
2570:
2566:
2562:
2556:
2553:
2551:
2548:
2547:
2542:
2539:
2537:
2534:
2532:
2529:
2528:
2527:
2526:Phospholipase
2524:
2523:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2474:
2471:
2469:
2466:
2465:
2464:
2461:
2460:
2457:
2454:
2452:
2449:
2447:
2444:
2440:
2437:
2435:
2432:
2431:
2430:
2427:
2426:
2424:
2420:
2416:
2412:
2407:
2403:
2399:
2392:
2387:
2385:
2380:
2378:
2373:
2372:
2369:
2363:
2360:
2358:
2355:
2354:
2346:(3) 371â382.
2345:
2341:
2338:
2334:
2333:
2327:
2318:
2314:
2309:
2304:
2300:
2296:
2292:
2288:
2284:
2277:
2269:
2265:
2260:
2255:
2251:
2247:
2243:
2236:
2228:
2224:
2219:
2214:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2177:
2169:
2165:
2160:
2155:
2151:
2147:
2143:
2136:
2128:
2124:
2120:
2116:
2112:
2108:
2105:(4): 585â97.
2104:
2100:
2096:
2089:
2081:
2077:
2072:
2067:
2063:
2059:
2055:
2051:
2047:
2040:
2032:
2028:
2023:
2018:
2013:
2008:
2004:
2000:
1996:
1989:
1981:
1977:
1972:
1967:
1964:(4): 506â17.
1963:
1959:
1955:
1948:
1938:
1929:
1921:
1917:
1912:
1907:
1904:(3): 462â74.
1903:
1899:
1895:
1888:
1880:
1876:
1871:
1866:
1862:
1858:
1855:(2): 144â51.
1854:
1850:
1846:
1839:
1831:
1825:
1817:
1813:
1808:
1803:
1799:
1795:
1791:
1787:
1783:
1776:
1768:
1764:
1759:
1754:
1749:
1744:
1740:
1736:
1735:PLOS Genetics
1732:
1725:
1717:
1711:
1707:
1706:
1698:
1690:
1684:
1680:
1679:
1671:
1663:
1659:
1655:
1651:
1647:
1643:
1636:
1632:
1625:
1623:
1619:
1615:
1610:
1600:
1598:
1584:
1583:
1578:
1575:
1572:
1569:
1568:
1563:
1560:
1557:
1554:
1553:
1548:
1545:
1542:
1539:
1538:
1533:
1530:
1527:
1523:
1522:
1517:
1514:
1511:
1508:
1505:
1504:
1499:
1496:
1493:
1490:as well as a
1489:
1485:
1484:
1479:
1476:
1473:
1470:
1467:
1464:as well as a
1463:
1459:
1458:
1453:
1450:
1447:
1444:
1443:
1433:
1432:
1427:
1424:
1421:
1417:
1416:
1411:
1408:
1405:
1402:
1401:
1396:
1393:
1390:
1387:
1386:
1381:
1378:
1375:
1372:
1371:
1366:
1363:
1360:
1357:
1356:
1351:
1348:
1345:
1342:
1341:
1336:
1333:
1330:
1326:
1322:
1318:
1314:
1310:
1306:
1305:
1300:
1297:
1294:
1291:
1290:
1286:3.1.26.-??:
1285:
1282:
1278:
1277:
1272:
1269:
1266:
1262:
1261:
1256:
1253:
1250:
1247:
1242:
1238:
1233:
1229:
1228:
1223:
1220:
1217:
1216:
1211:
1197:
1195:
1191:
1187:
1183:
1179:
1174:
1172:
1168:
1164:
1159:
1157:
1153:
1149:
1147:
1141:
1139:
1135:
1131:
1125:
1123:
1112:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1072:
1066:
1062:
1059:
1053:
1047:
1041:
1035:
1029:
1023:
1017:
1011:
1005:
999:
993:
987:
981:
975:
969:
963:
957:
951:
945:
939:
933:
927:
921:
915:
909:
903:
897:
891:
885:
879:
873:
867:
861:
855:
849:
843:
837:
831:
825:
819:
813:
807:
801:
795:
789:
783:
777:
771:
765:
759:
753:
747:
741:
735:
729:
723:
717:
711:
705:
699:
693:
687:
681:
675:
669:
663:
657:
651:
645:
639:
633:
627:
621:
615:
609:
603:
597:
591:
585:
579:
573:
567:
561:
555:
549:
543:
537:
531:
525:
519:
513:
507:
501:
495:
489:
483:
477:
471:
465:
459:
453:
447:
441:
435:
429:
423:
417:
411:
405:
399:
393:
387:
381:
375:
369:
363:
357:
351:
345:
339:
333:
327:
321:
315:
309:
303:
297:
291:
285:
279:
273:
267:
261:
255:
249:
243:
237:
231:
225:
219:
213:
207:
201:
194:
188:
182:
178:
176:
172:
169:
166:
164:
160:
157:
153:
149:
146:
144:
140:
136:
132:
129:
126:
122:
117:
113:
110:
106:
102:
99:
97:
93:
90:
87:
85:
81:
78:
75:
73:
69:
65:
61:
56:
51:
46:
41:
36:
31:
19:
3479:Translocases
3476:
3463:
3450:
3437:
3424:
3414:Transferases
3411:
3398:
3255:Binding site
3036:}}
3030:{{
2994:Endonuclease
2925:ribonuclease
2924:
2865:
2648:Nucleotidase
2569:Thioesterase
2343:
2336:
2325:
2290:
2286:
2276:
2249:
2245:
2235:
2193:(7): e6424.
2190:
2186:
2176:
2149:
2145:
2135:
2102:
2098:
2088:
2056:(5): 253â9.
2053:
2049:
2039:
2002:
1999:Microbiology
1998:
1988:
1961:
1957:
1947:
1937:
1928:
1901:
1897:
1887:
1852:
1849:EMBO Reports
1848:
1838:
1824:
1789:
1786:Biochemistry
1785:
1775:
1738:
1734:
1724:
1704:
1697:
1677:
1670:
1645:
1641:
1635:
1606:
1593:
1580:
1565:
1550:
1535:
1519:
1501:
1481:
1455:
1429:
1413:
1398:
1383:
1368:
1353:
1338:
1302:
1287:
1274:
1258:
1231:
1225:
1178:angiogenesis
1175:
1160:
1144:
1142:
1126:
1118:
1088:
1085:Ribonuclease
1084:
1083:
1068:A:83-175
1061:A:82-174
1055:A:82-174
1049:B:82-174
1043:A:82-174
983:A:46-129
953:A:46-129
941:A:46-129
929:A:46-129
923:A:46-129
911:B:46-129
905:A:46-129
899:A:46-129
893:A:46-129
887:A:46-129
881:A:46-129
875:A:46-129
869:C:46-129
845:A:46-129
839:A:46-129
821:D:46-129
803:B:46-129
797:B:46-129
767:A:46-129
761:A:46-129
755:A:46-129
749:A:46-129
743:A:46-129
737:A:46-129
731:A:46-129
719:D:46-129
707:A:46-129
701:A:46-129
695:A:46-129
683:A:46-129
677:B:46-129
671:A:46-129
665:A:46-129
641:D:46-129
635:A:46-129
629:B:46-129
623:A:46-129
611:A:46-129
605:A:46-129
599:M:67-156
593:B:67-156
587:C:67-156
581:A:67-156
575:A:67-156
569:B:67-156
563:A:67-156
557:C:67-156
551:A:67-156
545:C:67-156
539:C:67-156
527:C:67-156
515:B:67-156
509:C:67-156
503:C:67-156
497:C:67-156
491:B:67-156
485:B:67-156
479:C:67-156
473:A:67-156
467:B:67-156
461:B:67-156
455:B:67-156
449:B:67-156
443:C:67-156
437:B:67-156
431:B:67-156
425:B:67-156
419:B:67-156
413:A:67-156
407:C:67-156
401:C:67-156
395:A:67-156
389:B:67-156
383:A:67-156
377:B:67-156
371:A:72-161
365:A:72-161
359:B:72-161
353:A:72-161
347:B:72-161
341:A:79-159
335:B:79-159
329:X:11-92
323:B:11-92
317:B:11-92
311:B:11-92
305:B:11-92
299:A:11-92
293:A:11-92
287:B:11-92
281:A:11-92
275:A:11-92
269:B:11-92
263:A:11-92
257:A:11-92
251:B:11-92
245:A:11-92
239:A:11-92
233:B:11-92
227:A:11-92
221:B:11-92
215:B:11-92
209:A:11-92
203:A:11-92
197:
196:B:11-92
190:A:56-137
184:A:56-137
66:Ribonuclease
44:
33:ribonuclease
3250:Active site
3169:Nuclease S1
2940:Exonuclease
2834:Lecithinase
2663:Calcineurin
2601:Phosphatase
2507:Lipoprotein
2497:Endothelial
1488:exonuclease
1462:exonuclease
1161:Similar to
1037::23-113
1031::45-127
1025::45-127
1019::45-127
1013::45-127
1007::21-102
1001::21-102
995::46-129
989::46-129
977::46-129
971::46-129
965::46-129
959::46-129
947::46-129
935::46-129
917::46-129
863::46-129
857::46-129
851::46-129
833::46-129
827::46-129
815::46-129
809::46-129
791::46-129
785::46-129
779::46-129
773::46-129
725::46-129
713::46-129
689::46-129
659::46-129
653::46-129
647::46-129
617::46-129
533::67-156
521::67-156
58:Identifiers
3522:Categories
3453:Isomerases
3427:Hydrolases
3294:Regulation
2482:Pancreatic
2419:Carboxylic
1628:References
1435:structure.
1340:RNase PhyM
131:structures
3543:EC 3.1.27
3538:EC 3.1.26
3332:EC number
3059:RNase III
2917:(includes
2858:Sulfatase
2771:Autotaxin
2635:Prostatic
2487:Lysosomal
2402:esterases
2398:Hydrolase
1532:EC number
1510:EC number
1498:EC number
1472:EC number
1446:EC number
1410:3.1.26.12
1337:3.1.??:
1335:EC number
1284:EC number
1276:RNase III
1246:denatured
1132:, 3' end
1097:catalyzes
89:IPR000026
3356:Kinetics
3280:Cofactor
3243:Activity
3153:RNase T1
2915:Nuclease
2550:Cutinase
2317:18211964
2268:17150966
2227:19641608
2187:PLOS ONE
2168:12244054
2127:20922592
2119:16969722
2080:20189811
2031:19246759
1980:25458845
1920:18984158
1879:19165139
1816:21838247
1767:20011113
1662:20606265
1577:3.1.13.1
1562:3.1.11.1
1547:3.1.13.3
1534:3.1.??:
1516:3.1.13.5
1500:3.1.??:
1483:RNase PH
1478:2.7.7.56
1431:RNase G
1426:3.1.26.-
1415:RNase E
1395:3.1.27.8
1385:RNase U2
1380:3.1.27.4
1370:RNase T2
1365:3.1.27.1
1355:RNase T1
1350:3.1.27.3
1325:ribosome
1309:ribozyme
1299:3.1.26.5
1271:3.1.26.3
1264:product.
1255:3.1.26.4
1222:3.1.27.5
1194:homology
1115:Function
1093:nuclease
1074:A:83-175
148:RCSB PDB
84:InterPro
3512:Biology
3466:Ligases
3236:Enzymes
3126:RNase E
3121:RNase Z
3116:RNase A
3111:RNase P
3084:RNase H
2702:Phytase
2502:Hepatic
2477:Lingual
2473:Gastric
2330:Sources
2308:2692241
2218:2712763
2195:Bibcode
2071:2888479
2022:2662391
1870:2637324
1807:3172371
1758:2781298
1622:exapted
1618:RNase A
1537:RNase T
1521:RNase D
1503:RNase R
1452:2.7.7.8
1400:RNase V
1329:protein
1304:RNase P
1289:RNase L
1260:RNase H
1227:RNase A
77:PF00545
3533:EC 3.1
3498:Portal
3440:Lyases
3064:Drosha
2989:3.1.21
2957:RecBCD
2935:3.1.11
2555:PETase
2463:Lipase
2315:
2305:
2266:
2225:
2215:
2166:
2125:
2117:
2078:
2068:
2029:
2019:
1978:
1918:
1877:
1867:
1814:
1804:
1765:
1755:
1712:
1685:
1660:
1614:DNases
1597:CRISPR
1317:enzyme
1154:; the
163:PDBsum
137:
127:
109:SUPFAM
63:Symbol
3392:Types
3073:Dicer
3028:;see
2854:3.1.6
2824:PDE4B
2820:PDE4A
2758:3.1.4
2727:IMPA3
2723:IMPA2
2719:IMPA1
2597:3.1.3
2565:3.1.2
2415:3.1.1
2123:S2CID
1526:tRNAs
1095:that
1089:RNase
105:SCOPe
96:SCOP2
18:RNase
3484:list
3477:EC7
3471:list
3464:EC6
3458:list
3451:EC5
3445:list
3438:EC4
3432:list
3425:EC3
3419:list
3412:EC2
3406:list
3399:EC1
2991:-31:
2937:-16:
2923:and
2829:PDE5
2815:PDE3
2810:PDE2
2805:PDE1
2697:PTEN
2682:OCRL
2675:PP2A
2624:ALPP
2619:ALPL
2614:ALPI
2408:3.1)
2313:PMID
2264:PMID
2223:PMID
2164:PMID
2115:PMID
2076:PMID
2027:PMID
1976:PMID
1916:PMID
1898:Cell
1875:PMID
1812:PMID
1763:PMID
1710:ISBN
1683:ISBN
1658:PMID
1607:The
1321:tRNA
1311:â a
1241:2AAS
1232:e.g.
1180:and
1148:(RI)
1122:RNAi
1107:and
1071:1r4y
1065:1de3
1058:1jbs
1052:1jbt
1046:1jbr
1040:1aqz
1034:1rtu
1028:1rck
1022:1fus
1016:1rcl
1010:1fut
1004:1rds
998:1rms
992:1rgk
986:4rnt
980:1i2f
974:5rnt
968:8rnt
962:2aae
956:7rnt
950:1iyy
944:3gsp
938:1hyf
932:2gsp
926:2bu4
920:1i3i
914:1lra
908:2aad
902:1tto
896:2bir
890:1loy
884:1g02
878:5bir
872:1i3f
866:1q9e
860:3bir
854:9rnt
848:5gsp
842:1lov
836:1fzu
830:1rn4
824:1rgl
818:3hoh
812:2rnt
806:4bir
800:1rgc
794:1ch0
788:6rnt
782:1bu4
776:1gsp
770:1ygw
764:7gsp
758:5hoh
752:1trp
746:1hz1
740:5bu4
734:1rhl
728:4bu4
722:1rga
716:4hoh
710:1rnt
704:1rn1
698:3bu4
692:1i2g
686:1det
680:1trq
674:1bir
668:1i0x
662:1low
656:4gsp
650:6gsp
644:3rnt
638:2hoh
632:1i2e
626:1bvi
620:1fys
614:1rls
608:1i0v
602:1b2m
596:1brn
590:1x1x
584:1b21
578:1rnb
572:1fw7
566:1x1u
560:1a2p
554:1bng
548:1bne
542:1brj
536:1brs
530:1yvs
524:1b2s
518:1bnr
512:1b20
506:1b27
500:1b2u
494:1bri
488:1x1y
482:1bse
476:1bsc
470:1b2z
464:1b2x
458:1bni
452:1x1w
446:1b3s
440:1bsb
434:1bsa
428:1bnj
422:1bgs
416:1bnf
410:1bns
404:1brk
398:1brg
392:1brh
386:1ban
380:1bsd
374:1bao
368:1buj
362:1gov
356:1gou
350:1goy
344:2rbi
338:1pyl
332:1py3
326:1ynv
320:1gmr
314:1i8v
308:1rgh
302:1rgg
296:1rgf
290:1gmp
284:1sar
278:1uci
272:1gmq
266:1rsn
260:1c54
254:1t2i
248:1rge
242:1ucl
236:1box
230:1t2h
224:1ay7
218:1lni
212:1ucj
206:2sar
200:1i70
193:1uck
187:1mgr
181:1mgw
156:PDBj
152:PDBe
135:ECOD
125:Pfam
101:1brn
72:Pfam
50:3agn
3146:4/5
2303:PMC
2295:doi
2254:doi
2250:282
2213:PMC
2203:doi
2154:doi
2150:277
2107:doi
2066:PMC
2058:doi
2017:PMC
2007:doi
2003:155
1966:doi
1906:doi
1902:135
1865:PMC
1857:doi
1802:PMC
1794:doi
1753:PMC
1743:doi
1650:doi
1454::
1237:PDB
1184:in
1167:DNA
1101:RNA
175:PDB
143:PDB
3524::
3104:2C
3099:2B
3094:2A
3075::
3066::
2856::
2736::
2725:,
2721:,
2637:)/
2599::
2567::
2536:A2
2531:A1
2417::
2406:EC
2400::
2311:.
2301:.
2291:83
2289:.
2285:.
2262:.
2248:.
2244:.
2221:.
2211:.
2201:.
2189:.
2185:.
2162:.
2148:.
2144:.
2121:.
2113:.
2103:10
2101:.
2097:.
2074:.
2064:.
2054:35
2052:.
2048:.
2025:.
2015:.
2001:.
1997:.
1974:.
1962:56
1960:.
1956:.
1914:.
1900:.
1896:.
1873:.
1863:.
1853:10
1851:.
1847:.
1810:.
1800:.
1790:50
1788:.
1784:.
1761:.
1751:.
1737:.
1733:.
1656:.
1646:66
1644:.
1579::
1574:EC
1564::
1559:EC
1549::
1544:EC
1518::
1513:EC
1480::
1475:EC
1449:EC
1428::
1423:EC
1412::
1407:EC
1397::
1392:EC
1382::
1377:EC
1367::
1362:EC
1352::
1347:EC
1301::
1296:EC
1273::
1268:EC
1257::
1252:EC
1239::
1224::
1219:EC
1196:.
1124:.
154:;
150:;
133:/
107:/
103:/
3500::
3486:)
3482:(
3473:)
3469:(
3460:)
3456:(
3447:)
3443:(
3434:)
3430:(
3421:)
3417:(
3408:)
3404:(
3228:e
3221:t
3214:v
3141:3
3136:2
3131:1
3089:1
2927:)
2840:)
2836:(
2822:/
2798:1
2786:D
2781:C
2760::
2641:/
2633:(
2541:B
2475:/
2404:(
2390:e
2383:t
2376:v
2319:.
2297::
2270:.
2256::
2229:.
2205::
2197::
2191:4
2170:.
2156::
2129:.
2109::
2082:.
2060::
2033:.
2009::
1982:.
1968::
1922:.
1908::
1881:.
1859::
1832:.
1818:.
1796::
1769:.
1745::
1739:5
1718:.
1691:.
1664:.
1652::
1528:.
1494:.
1468:.
20:)
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