Knowledge

Pseudopodia

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enveloped by cytoplasm. Axopodia are mostly responsible for phagocytosis by rapidly retracting in response to physical contact. These pseudopodia are primarily food-collecting structures, but also provide a means of hydrological transportation via the expansion of their surface areas. They are
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Reticulopodia (or reticulose pseudopods), are complex formations in which individual pseudopods are merged and form irregular nets. The primary function of reticulopodia, also known as myxopodia, is food ingestion, with locomotion a secondary function. Reticulopods are typical of
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In the case there is no extracellular cue, all moving cells navigate in random directions, but they can keep the same direction for some time before turning. This feature allows cells to explore large areas for colonization or searching for a new extracellular cue.
629:, cell-derived matrix). Contrarily to other pseudopodia using the pressure exerted by actin polymerization on the membrane to extend, fibroblast lobopods use the nuclear piston mechanism consisting in pulling the nucleus via actomyosin contractility to push the 1160:
Houk, Andrew R.; Jilkine, Alexandra; Mejean, Cecile O.; Boltyanskiy, Rostislav; Dufresne, Eric R.; Angenent, Sigurd B.; Altschuler, Steven J.; Wu, Lani F.; Weiner, Orion D. (2012-01-20).
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Otherwise, pseudopodia cannot grow on other sides of the membrane than the leading edge because myosin filaments prevent them to extend. These myosin filaments are induced by
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Lamellipodia are broad and flat pseudopodia used in locomotion. They are supported by microfilaments which form at the leading edge, creating a mesh-like internal network.
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forming along the side of the cell, probably due to the high intracellular pressure during lobopodia formation increasing the frequency of plasma membrane-cortex rupture.
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The forms of pseudopodia, from left: polypodial and lobose; monopodial and lobose; filose; conical; reticulose; tapering actinopods; non-tapering actinopods
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Pseudopods can be classified into several varieties according to the number of projections (monopodia and polypodia), and according to their appearance.
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Different physical parameters were shown to regulate the length and time-scale of pseudopodia formation. For example, an increase in membrane
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type with long, thin pseudopods supported by complex microtubule arrays enveloped with cytoplasm; they respond rapidly to physical contact.
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are a good example of this function: these migratory cells are responsible for in-utero remodeling; for example, in the formation of the
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Banerjee, Tatsat; Biswas, Debojyoti; Pal, Dhiman Sankar; Miao, Yuchuan; Iglesias, Pablo A.; Devreotes, Peter N. (2022-10-06).
1305: 922: 777:"The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration" 590:
Lobopodia (or lobose pseudopods) are bulbous, short, and blunt in form. These finger-like, tubular pseudopodia contain both
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Some pseudopodial cells are able to use multiple types of pseudopodia depending on the situation. Most use a combination of
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to advance relatively straight forward by alternating between retraction of the left or right branch of the pseudopod. The
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Bogitsh, Burton J.; Carter, Clint E.; Oeltmann, Thomas N. (2013). "General Characteristics of the Euprotista (Protozoa)".
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that in turn push the membrane, leading to pseudopod formation. To occur, this lobopodia-based fibroblast migration needs
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fibroblasts can either use lamellipodia- or lobopodia-based migration in a 3D matrix depending on the matrix elasticity.
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ones, which explain the preference of the cell to keep moving to the same direction. This persistence is modulated by
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stimulation. This serves as a feedback loop to amplify and maintain the presence of local GTPase at the leading edge.
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Chengappa P; et al. (2018). "Chapter Seven - Intracellular Pressure: A Driver of Cell Morphology and Movement".
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Pseudopodia are critical in sensing targets which can then be engulfed; the engulfing pseudopodia are called
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are slender, thread-like, and are supported largely by microfilaments. Lobopodia are bulbous and amoebic.
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Filopodia (or filose pseudopods) are slender and filiform with pointed ends, consisting mainly of
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pseudopodia form at different sides than pre-existing ones, they are used by the cells to turn.
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inhibits actin assembly and protrusion formation. It was demonstrated that the lowered negative
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which, unlike the filaments of lamellipodia with their net-like actin, form loose bundles by
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Machesky LM; et al. (2008). "Lamellipodia and filopodia in metastasis and invasion".
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Axopodia (also known as actinopodia) are narrow pseudopodia containing complex arrays of
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cells), to extend pseudopodia at the membrane area facing the source of these molecules.
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Van Haastert PJM & Devreotes PN (2004). "Chemotaxis: signalling the way forward".
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False leg found on slime molds, archaea, protozoans, leukocytes and certain bacteria
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are complex structures bearing individual pseudopodia which form irregular nets.
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Different types of pseudopodia can be classified by their distinct appearances.
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as normal, or from an existing pseudopod, forming a Y-shaped pseudopodium.
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Campbell EJ (2017). "A computational model of amoeboid cell swimming".
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Generally, several pseudopodia arise from the surface of the body, (
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pseudopodia. A common example of this type of amoeboid cell is the
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Conti MA (2008). "Nonmuscle myosin II moves in new directions".
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The functions of pseudopodia include locomotion and ingestion:
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They are also essential to amoeboid-like locomotion. Human
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that is emerged in the direction of movement. Filled with
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This article is about eukaryotic cells. For the band, see
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Cell Movements: From molecules to motility second edition
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Cells which make pseudopods are generally referred to as
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to the membrane at the leading edge and detach the PIP
1216: 904: 717: 723: 617:High-pressure lobopodia can also be found in human 1547:International Review of Cell and Molecular Biology 1471: 2313: 510:to migrate (e.g. metastatic cancer cells). Human 2852: 401:generates protrusions via activation of the Ras- 1288:(4th ed.). Churchill Livingstone Elsevier. 1034: 1032: 1030: 970: 968: 2274: 1672: 1538: 1465: 1395: 1393: 1345: 408: 1544: 1449: 1447: 1351: 1081: 1075: 1027: 965: 621:travelling through a complex network of 3D 439:Y-shaped pseudopods are more frequent than 38:. For the structure in insect anatomy, see 1679: 1665: 1573: 1390: 1283: 975:Bosgraaf L & Van Haastert PJM (2009). 178:) is a temporary arm-like projection of a 2181: 1607: 1597: 1579: 1497: 1474:"Role of fascin in filopodial protrusion" 1427: 1399: 1328: 1318: 1252: 1193: 1110: 1010: 1000: 804: 794: 743: 135:Learn how and when to remove this message 1472:Danijela Vignjevic; et al. (2006). 1444: 1116: 490: 281:To move towards a target, the cell uses 276: 146: 1292: 774: 768: 357:from the same area of the membrane. PIP 14: 2853: 421:cells, a pseudopodium can form either 1660: 1306:International Journal of Cell Biology 1298: 1041:Nature Reviews Molecular Cell Biology 827: 1453: 861: 859: 857: 855: 853: 534:. These formations are supported by 428:The Y-shaped pseudopods are used by 317:which serve as nucleation sites for 73:adding citations to reliable sources 44: 189:, pseudopodia primarily consist of 167: 24: 915:10.1016/B978-0-12-415915-0.00003-0 25: 2882: 850: 309:Rho GTPases are able to activate 745:10.1111/j.1600-0854.2004.00196.x 660: 296:G protein-coupled receptors 49: 1624: 1580:Petrie RJ; et al. (2017). 1514: 1400:Petrie RJ; et al. (2012). 1277: 1210: 1153: 517: 361:then activate GTPases back via 60:needs additional citations for 2426:Membranous/thalloid/foliaceous 939: 898: 821: 447:and cGMP signalling pathways. 338:Rho GTPases can also activate 13: 1: 2396:Tetrasporal/capsal/palmelloid 1368:10.1016/j.febslet.2008.03.039 724:Etienne-Manneville S (2004). 710: 486: 340:phosphatidylinositol 3-kinase 294:The chemoattractants bind to 229: 1559:10.1016/bs.ircmb.2017.12.005 1002:10.1371/journal.pone.0005253 585: 525: 450: 397:on the inner surface of the 262: 154:extending lobose pseudopodia 7: 1299:Xue F; et al. (2010). 689: 10: 2887: 1522:"Pseudopodium | cytoplasm" 1237:10.1038/s41556-022-00997-7 1178:10.1016/j.cell.2011.10.050 209:. They are often found in 201:. 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For the podcast, see 2861:Actin-based structures 2750:Microbial biogeography 496: 472:mesenchymal stem cells 302:(e.g. Cdc42, Rac) via 199:intermediate filaments 155: 1770:Fungus-like organisms 1599:10.1083/jcb.201605097 1490:10.1083/jcb.200603013 1420:10.1083/jcb.201201124 494: 342:(PI3K) which recruit 277:Via extracellular cue 256:Entamoeba histolytica 193:and may also contain 150: 2485:Simple cell membrane 2421:Pseudoparenchymatous 2409:Filamentous/trichal/ 2393:Colonial flagellated 2326:Collar of microvilli 828:Patterson, David J. 782:Respiratory Research 476:trilaminar germ disc 405:signalling pathway. 319:actin polymerization 220:are broad and thin. 69:improve this article 2699:Contractile vacuole 2650:Meiosis in protists 2631:Mitosis in protists 2609:Multinucleate cells 1831:Flagellar apparatus 1780:Ambiregnal protists 1722:Sarcodina/Amoeboids 1320:10.1155/2010/507821 1224:Nature Cell Biology 1096:2017PhFl...29j1902C 993:2009PLoSO...4.5253B 36:Pseudopod (podcast) 2530:Periplast/pellicle 2253:Periplast/pellicle 2193:Cruciform division 1131:10.1242/jcs.007112 909:. pp. 37–51. 907:Human Parasitology 497: 353:-degrading enzyme 156: 2848: 2847: 2745:Microbial ecology 2731: 2730: 2727: 2726: 2704:Eyespot apparatus 2334: 2333: 2316:Choanoflagellates 2300: 2299: 2261: 2260: 2201: 2200: 2168: 2167: 2034: 2033: 1956: 1955: 1891: 1890: 1231:(10): 1499–1515. 1104:10.1063/1.4990543 1084:Physics of Fluids 924:978-0-12-415915-0 332:amoeboid movement 323:adhesion proteins 298:, which activate 145: 144: 137: 119: 16:(Redirected from 2878: 2719:Mastigont system 2672: 2597: 2574: 2563:Gliding motility 2541: 2478: 2423:/plektenchymatic 2379:Amoeboflagellate 2352: 2343: 2342: 2319: 2311: 2310: 2280: 2272: 2271: 2246: 2220: 2212: 2211: 2186: 2179: 2178: 2143: 2107: 2076: 2050: 2045: 2044: 2014: 1993: 1972: 1967: 1966: 1936: 1910: 1902: 1901: 1871: 1845: 1809: 1802: 1801: 1793: 1792: 1681: 1674: 1667: 1658: 1657: 1651: 1650: 1648: 1647: 1638:. 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1495: 1491: 1487: 1483: 1479: 1475: 1468: 1460: 1456: 1450: 1448: 1439: 1435: 1430: 1425: 1421: 1417: 1413: 1409: 1408: 1403: 1396: 1394: 1385: 1381: 1377: 1373: 1369: 1365: 1361: 1357: 1356: 1348: 1340: 1336: 1331: 1326: 1321: 1316: 1312: 1308: 1307: 1302: 1295: 1287: 1280: 1272: 1268: 1264: 1260: 1255: 1250: 1246: 1242: 1238: 1234: 1230: 1226: 1225: 1220: 1213: 1205: 1201: 1196: 1191: 1187: 1183: 1179: 1175: 1171: 1167: 1163: 1156: 1148: 1144: 1140: 1136: 1132: 1128: 1124: 1120: 1113: 1105: 1101: 1097: 1093: 1089: 1085: 1078: 1070: 1066: 1062: 1058: 1054: 1050: 1046: 1042: 1035: 1033: 1031: 1022: 1018: 1013: 1008: 1003: 998: 994: 990: 986: 982: 978: 971: 969: 954: 953: 948: 947:"Pseudopodia" 942: 934: 930: 926: 920: 916: 912: 908: 901: 893: 887: 872: 868: 867:"Pseudopodia" 862: 860: 858: 856: 854: 839: 835: 831: 824: 816: 812: 807: 802: 797: 792: 788: 784: 783: 778: 771: 763: 759: 755: 751: 746: 741: 738:(7): 470–77. 737: 733: 732: 727: 720: 716: 708: 706: 702: 699:observed in " 697: 687: 685: 684: 679: 678: 673: 672:Chlorarachnea 669: 661:Reticulopodia 658: 656: 652: 648: 644: 640: 636: 632: 628: 624: 620: 615: 613: 609: 608:Heterolobosea 605: 601: 597: 593: 583: 581: 577: 573: 569: 568:Pseudosporida 565: 564:Vampyrellidae 561: 557: 553: 549: 545: 541: 540:cross-linking 537: 533: 523: 515: 513: 509: 505: 500: 493: 481: 477: 473: 469: 466: 462: 458: 457: 456: 448: 446: 442: 437: 435: 431: 430:Dictyostelium 426: 424: 420: 419:Dictyostelium 415: 406: 404: 403:PI3K/AKT/mTOR 400: 396: 392: 387: 386:for example. 385: 381: 377: 376: 375:D. discoideum 371: 366: 364: 356: 348: 341: 336: 334: 333: 328: 324: 320: 316: 312: 307: 305: 301: 297: 292: 290: 289: 288:Dictyostelium 284: 274: 272: 271: 260: 258: 257: 252: 248: 247: 242: 237: 235: 231: 227: 226:Reticulopodia 223: 219: 214: 212: 208: 204: 200: 196: 192: 188: 184: 183:cell membrane 181: 177: 173: 165: 161: 153: 149: 139: 136: 128: 117: 114: 110: 107: 103: 100: 96: 93: 89: 86: β€“  85: 84:"Pseudopodia" 81: 80:Find sources: 74: 70: 64: 63: 58:This article 56: 52: 47: 46: 41: 37: 33: 19: 2866:Cell anatomy 2796:Heterotrophy 2766:Reproduction 2641:Orthomitosis 2626:Heterokaryon 2573:Mitochondria 2557: 2474:Cell surface 2350:organization 2306:Opisthokonta 2129:Micronucleus 2124:Macronucleus 2026:Pneumatocyst 1842:Glaucophytes 1826:Phragmoplast 1765:Thallophytes 1692:Protistology 1688:Microbiology 1644:. Retrieved 1640:the original 1635: 1626: 1589: 1585: 1575: 1550: 1546: 1540: 1529:. Retrieved 1525: 1516: 1481: 1477: 1467: 1458: 1455:Bray, Dennis 1411: 1405: 1359: 1355:FEBS Letters 1353: 1347: 1310: 1304: 1294: 1285: 1279: 1228: 1222: 1212: 1169: 1165: 1155: 1122: 1118: 1112: 1087: 1083: 1077: 1044: 1040: 984: 980: 956:. Retrieved 950: 941: 906: 900: 875:. Retrieved 870: 841:. Retrieved 833: 823: 786: 780: 770: 735: 729: 719: 696:microtubules 693: 686:(Rhizaria). 681: 675: 668:Foraminifera 664: 616: 606:and in some 589: 580:Opisthokonta 529: 521: 518:Lamellipodia 504:lamellipodia 501: 498: 480:gastrulation 461:phagocytosis 454: 440: 438: 433: 429: 427: 422: 418: 416: 412: 388: 373: 367: 337: 330: 308: 293: 286: 280: 268: 266: 254: 250: 244: 240: 238: 234:phagocytosis 218:Lamellipodia 215: 195:microtubules 175: 171: 164:pseudopodium 163: 159: 157: 151: 131: 125:October 2007 122: 112: 105: 98: 91: 79: 67:Please help 62:verification 59: 2826:Necrotrophy 2811:Saprotrophy 2801:Phagotrophy 2789:Phototrophy 2782:Nutrition: 2771:Life cycles 2762:Development 2736:Ecology and 2604:Nucleomorph 2558:Pseudopodia 2359:Unicellular 2243:Euglenoidea 2227:Kinetoplast 2011:Brown algae 1979:Mastigoneme 1917:Mastigoneme 1907:Cryptophyta 1817:green algae 1775:Slime molds 1553:: 185–211. 619:fibroblasts 576:Nucleariida 384:neutrophils 176:pseudopodia 2855:Categories 2840:Auxotrophy 2835:Mixotrophy 2816:Parasitism 2806:Osmotrophy 2784:Autotrophy 2738:physiology 2614:Plasmodium 2540:Locomotion 2476:structures 2440:Coenocytic 2184:Phytomyxea 2155:Apicoplast 2083:Dinokaryon 2062:Trichocyst 1933:Haptophyte 1821:Phycoplast 1789:Morphology 1760:Cryptogams 1646:2005-12-30 1531:2018-12-16 958:2018-12-16 877:2018-12-16 871:Arcella.nl 843:2017-11-12 834:tolweb.org 711:References 701:Radiolaria 602:and other 487:Morphology 465:macrophage 380:Rho kinase 370:cyclic GMP 283:chemotaxis 253:, such as 251:monopodial 241:polypodial 180:eukaryotic 172:pseudopods 95:newspapers 2821:Biotrophy 2694:Extrusome 2684:Cytostome 2548:Flagellum 2505:Cell wall 2464:/histonal 2444:Siphonous 2435:Syncytial 2403:Coenobial 2399:Sarcinoid 2348:Levels of 2287:Macrocyst 2267:Amoebozoa 2232:Glycosome 2160:Microneme 2040:Alveolata 1948:Haptonema 1943:Coccolith 1922:Periplast 1868:Red algae 1852:Cyanelles 1739:Infusoria 1271:248990694 1245:1476-4679 1186:0092-8674 789:(1): 54. 651:myosin II 639:integrins 635:nesprin 3 631:cytoplasm 604:Amoebozoa 596:endoplasm 592:ectoplasm 586:Lobopodia 574:) and in 532:ectoplasm 526:Filopodia 508:filopodia 451:Functions 327:integrins 270:amoeboids 263:Formation 222:Filopodia 207:ingestion 187:cytoplasm 160:pseudopod 18:Pseudopod 2714:Axostyle 2709:Pyrenoid 2689:Fimbriae 2621:Dikaryon 2586:Mitosome 2515:Skeleton 2500:Frustule 2490:Mucilage 2462:tissular 2386:Colonial 2369:Amoeboid 2364:Monadoid 2292:Sorocarp 2207:Excavate 2174:Rhizaria 2104:Ciliates 2088:Dinocyst 2049:General: 2000:Frustule 1971:General: 1897:Hacrobia 1748:Sporozoa 1743:Ciliates 1732:Heliozoa 1712:Protozoa 1696:Protists 1618:27998990 1567:29551161 1508:16966425 1457:(2001). 1438:22547408 1384:46438967 1376:18396168 1339:20671957 1313:: 1–13. 1263:36202973 1254:10029748 1204:22265410 1147:16367236 1139:18096687 1061:15366706 1021:19384419 981:PLOS ONE 933:83272826 886:cite web 815:28390425 762:23083215 754:15180824 705:Heliozoa 703:" and " 690:Axopodia 683:Filoreta 612:Excavata 572:Rhizaria 556:Rhizaria 544:fimbrins 512:foreskin 232:are the 230:Axopodia 203:motility 2657:Zygotic 2654:Gametic 2596:Nucleus 2374:Coccoid 2339:General 2150:Rhoptry 2057:Alveoli 1990:Diatoms 1727:Testate 1636:eForams 1609:5223602 1499:2064340 1429:3341168 1330:2910478 1195:3308728 1092:Bibcode 1069:5687127 1012:2668753 989:Bibcode 806:5385055 731:Traffic 558:), in " 548:fascins 478:during 441:de novo 434:de novo 423:de novo 391:tension 211:amoebas 109:scholar 2660:Sporic 2638:Closed 2553:Cilium 2510:Lorica 2411:hyphal 2119:Cirrus 2114:Cilium 2021:Lamina 1703:Former 1616:  1606:  1565:  1506:  1496:  1436:  1426:  1382:  1374:  1337:  1327:  1269:  1261:  1251:  1243:  1202:  1192:  1184:  1145:  1137:  1067:  1059:  1019:  1009:  931:  921:  813:  803:  760:  752:  677:Gromia 627:dermis 623:matrix 600:Lobosa 562:", in 552:Filosa 325:(e.g. 111:  104:  97:  90:  82:  40:Proleg 2671:Other 2525:Theca 2495:Scale 2093:Theca 1755:Algae 1380:S2CID 1267:S2CID 1143:S2CID 1065:S2CID 929:S2CID 758:S2CID 655:blebs 116:JSTOR 102:books 2679:Cyst 2635:Open 2520:Test 2458:s.s. 2389:s.s. 1614:PMID 1563:PMID 1504:PMID 1434:PMID 1372:PMID 1335:PMID 1311:2010 1259:PMID 1241:ISSN 1200:PMID 1182:ISSN 1166:Cell 1135:PMID 1057:PMID 1017:PMID 919:ISBN 892:link 811:PMID 750:PMID 680:and 649:and 647:ROCK 643:RhoA 594:and 566:and 546:and 506:and 445:PLA2 355:PTEN 311:WASp 205:and 197:and 88:news 1819:": 1604:PMC 1594:doi 1590:216 1555:doi 1551:337 1494:PMC 1486:doi 1482:174 1424:PMC 1416:doi 1412:197 1364:doi 1360:582 1325:PMC 1315:doi 1249:PMC 1233:doi 1190:PMC 1174:doi 1170:148 1127:doi 1123:121 1100:doi 1049:doi 1007:PMC 997:doi 911:doi 801:PMC 791:doi 740:doi 707:". 614:). 582:). 417:In 382:in 378:or 372:in 363:GEF 344:PIP 259:). 174:or 168:pl. 162:or 71:by 2857:: 1694:: 1690:: 1634:. 1612:. 1602:. 1588:. 1584:. 1561:. 1549:. 1524:. 1502:. 1492:. 1480:. 1476:. 1446:^ 1432:. 1422:. 1410:. 1404:. 1392:^ 1378:. 1370:. 1358:. 1333:. 1323:. 1309:. 1303:. 1265:. 1257:. 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eukaryotic
cell membrane
cytoplasm
actin filaments
microtubules
intermediate filaments
motility
ingestion
amoebas
Lamellipodia
Filopodia
Reticulopodia
Axopodia
phagocytosis

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