17:
63:
Released pneumolysin will aid the bacteria during colonization by facilitating adherence to the host, during invasion by damaging host cells and during infection by interfering with the host immune response.
488:
486:
Lahti, E; Mertsola, J; Kontiokari, T; Eerola, E; et al. (December 2006). "Pneumolysin polymerase chain reaction for diagnosis of pneumococcal pneumonia and empyema in children".
414:
Rajalakshmi, B; Kanungo, R; Srinivasan, S; Badrinath, S (Oct–Dec 2002). "Pneumolysin in urine: A rapid antigen detection method to diagnose pneumococcal pneumonia in children".
565:
305:
552:
106:
Rossjohn, J; Gilbert, RJ; Crane, D; Morgan, PJ; et al. (Nov 27, 1998). "The molecular mechanism of pneumolysin, a virulence factor from
268:
Rubins, JB; Paddock, AH; Charboneau, D; Berry, AM; et al. (December 1998). "Pneumolysin in pneumococcal adherence and colonization".
145:
Marriott, HM; Mitchell, TJ; Dockrell, DH (September 2008). "Pneumolysin: A double-edged sword during the host-pathogen interaction".
180:
Baba, H; Kawamura, I; Kohda, C; Nomura, T; et al. (February 16, 2001). "Essential role of domain 4 of pneumolysin from
379:
Wheeler, J; Freeman, R; Steward, M; Henderson, K; et al. (September 1999). "Detection of pneumolysin in sputum".
545:
574:
538:
525:
303:
Rubins, JB; Janoff, EN (January 1998). "Pneumolysin: A multifunctional pneumococcal virulence factor".
694:
37:
340:
Cockeran, R; Anderson, R; Feldman, C (June 2002). "The role of pneumolysin in the pathogenesis of
84:
8:
76:
53:
16:
561:
245:
220:
45:
318:
505:
468:
423:
396:
361:
357:
322:
285:
250:
236:
201:
162:
127:
60:
and interfere with the function of cells and soluble molecules of the immune system.
463:
442:
643:
497:
458:
388:
353:
314:
277:
240:
232:
193:
154:
119:
28:
447:
meningitis by polymerase chain reaction amplification of the gene for pneumolysin"
441:
Matos Jde, A; Madureira, DJ; Rebelo, MC; Hofer, CB; et al. (August 2006).
158:
530:
501:
392:
688:
32:
582:
509:
472:
427:
400:
365:
281:
254:
205:
197:
166:
123:
326:
289:
131:
648:
49:
57:
592:
413:
219:
Hirst, RA; Kadioglu, A; O'callaghan, C; Andrew, PW (November 2004).
663:
658:
653:
638:
622:
597:
587:
489:
European
Journal of Clinical Microbiology & Infectious Diseases
221:"The role of pneumolysin in pneumococcal pneumonia and meningitis"
218:
68:
378:
668:
485:
440:
80:
72:
267:
184:
in cytolytic activity as determined by truncated proteins".
605:
601:
105:
144:
339:
179:
186:
686:
560:
306:The Journal of Laboratory and Clinical Medicine
546:
302:
553:
539:
462:
244:
15:
687:
416:Indian Journal of Medical Microbiology
346:Current Opinion in Infectious Diseases
534:
225:Clinical and Experimental Immunology
13:
451:Memórias do Instituto Oswaldo Cruz
14:
706:
519:
358:10.1097/00001432-200206000-00004
237:10.1111/j.1365-2249.2004.02611.x
575:Antimicrobial cationic peptides
479:
464:10.1590/s0074-02762006000500014
434:
381:Journal of Medical Microbiology
67:The presence of pneumolysin in
407:
372:
333:
296:
261:
212:
173:
138:
99:
1:
319:10.1016/s0022-2143(98)90073-7
93:
112:Journal of Molecular Biology
7:
56:, including the ability to
20:3D structure of pneumolysin
10:
711:
159:10.2174/156652408785747924
147:Current Molecular Medicine
48:of 53 kDa composed of 471
631:
615:
573:
502:10.1007/s10096-006-0225-9
393:10.1099/00222615-48-9-863
445:Streptococcus pneumoniae
342:Streptococcus pneumoniae
182:Streptococcus pneumoniae
108:Streptococcus pneumoniae
83:can be indicative of an
38:Streptococcus pneumoniae
282:10.1006/mpat.1998.0239
270:Microbial Pathogenesis
198:10.1006/bbrc.2001.4297
124:10.1006/jmbi.1998.2167
21:
19:
52:. It has a range of
562:Pore-forming toxins
526:World Pneumonia Day
54:biological activity
46:pore-forming toxin
22:
682:
681:
702:
695:Bacterial toxins
644:Diphtheria toxin
555:
548:
541:
532:
531:
514:
513:
483:
477:
476:
466:
438:
432:
431:
411:
405:
404:
376:
370:
369:
337:
331:
330:
300:
294:
293:
265:
259:
258:
248:
216:
210:
209:
177:
171:
170:
142:
136:
135:
103:
29:virulence factor
710:
709:
705:
704:
703:
701:
700:
699:
685:
684:
683:
678:
632:Other, nonhuman
627:
611:
569:
559:
522:
517:
484:
480:
439:
435:
412:
408:
377:
373:
338:
334:
301:
297:
266:
262:
217:
213:
178:
174:
143:
139:
104:
100:
96:
12:
11:
5:
708:
698:
697:
680:
679:
677:
676:
671:
666:
661:
656:
651:
646:
641:
635:
633:
629:
628:
626:
625:
619:
617:
613:
612:
610:
609:
595:
590:
585:
579:
577:
571:
570:
558:
557:
550:
543:
535:
529:
528:
521:
520:External links
518:
516:
515:
478:
443:"Diagnosis of
433:
406:
371:
332:
295:
260:
231:(2): 195–201.
211:
172:
153:(6): 497–509.
137:
97:
95:
92:
9:
6:
4:
3:
2:
707:
696:
693:
692:
690:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
636:
634:
630:
624:
621:
620:
618:
614:
607:
603:
599:
596:
594:
591:
589:
586:
584:
581:
580:
578:
576:
572:
567:
563:
556:
551:
549:
544:
542:
537:
536:
533:
527:
524:
523:
511:
507:
503:
499:
496:(12): 783–9.
495:
491:
490:
482:
474:
470:
465:
460:
457:(5): 559–63.
456:
452:
448:
446:
437:
429:
425:
421:
417:
410:
402:
398:
394:
390:
386:
382:
375:
367:
363:
359:
355:
351:
347:
343:
336:
328:
324:
320:
316:
312:
308:
307:
299:
291:
287:
283:
279:
276:(6): 337–42.
275:
271:
264:
256:
252:
247:
242:
238:
234:
230:
226:
222:
215:
207:
203:
199:
195:
191:
187:
183:
176:
168:
164:
160:
156:
152:
148:
141:
133:
129:
125:
121:
118:(2): 449–61.
117:
113:
109:
102:
98:
91:
89:
87:
86:S. pneumoniae
82:
78:
74:
70:
65:
61:
59:
55:
51:
47:
42:
40:
39:
34:
33:Gram-positive
30:
26:
18:
673:
616:Other, human
583:Cathelicidin
493:
487:
481:
454:
450:
444:
436:
422:(4): 183–6.
419:
415:
409:
387:(9): 863–6.
384:
380:
374:
352:(3): 235–9.
349:
345:
344:infection".
341:
335:
310:
304:
298:
273:
269:
263:
228:
224:
214:
192:(1): 37–44.
189:
185:
181:
175:
150:
146:
140:
115:
111:
107:
101:
85:
66:
62:
43:
36:
24:
23:
674:Pneumolysin
649:Dermaseptin
313:(1): 21–7.
50:amino acids
25:Pneumolysin
94:References
35:bacteria
593:Dermcidin
88:infection
689:Category
664:Melittin
659:Magainin
654:Latarcin
639:Cecropin
623:Perforin
598:Histatin
588:Defensin
510:17089094
473:17072463
428:17657067
401:10482298
366:12015456
255:15498026
206:11178957
167:18781957
44:It is a
327:9452123
290:9895272
246:1809205
132:9813129
31:of the
508:
471:
426:
399:
364:
325:
288:
253:
243:
204:
165:
130:
69:sputum
669:Nisin
566:TC 1C
81:blood
73:urine
27:is a
606:HTN3
602:HTN1
506:PMID
469:PMID
424:PMID
397:PMID
362:PMID
323:PMID
286:PMID
251:PMID
202:PMID
163:PMID
128:PMID
79:and
58:lyse
498:doi
459:doi
455:101
389:doi
354:doi
315:doi
311:131
278:doi
241:PMC
233:doi
229:138
194:doi
190:281
155:doi
120:doi
116:284
110:".
77:CSF
691::
604:,
504:.
494:25
492:.
467:.
453:.
449:.
420:20
418:.
395:.
385:48
383:.
360:.
350:15
348:.
321:.
309:.
284:.
274:25
272:.
249:.
239:.
227:.
223:.
200:.
188:.
161:.
149:.
126:.
114:.
90:.
75:,
71:,
41:.
608:)
600:(
568:)
564:(
554:e
547:t
540:v
512:.
500::
475:.
461::
430:.
403:.
391::
368:.
356::
329:.
317::
292:.
280::
257:.
235::
208:.
196::
169:.
157::
151:8
134:.
122::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
