32:
1080:
260:
1943:
Ezzeddini R, Darabi M, Ghasemi B, Jabbari
Moghaddam Y, Jabbari Y, Abdollahi S, et al. (April 2012). "Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis".
1051:
3642:
3588:
2190:
Guan M, Qu L, Tan W, Chen L, Wong CW (February 2011). "Hepatocyte nuclear factor-4 α regulates liver triglyceride metabolism in part through secreted phospholipase AA
406:
211:
274:
Middle plane of the lipid bilayer - black dots. Boundary of the hydrocarbon core region - red dots (extracellular side). Layer of lipid phosphates - yellow dots.
2837:
1035:, of the bridging water molecule. The rate limiting state is characterized as the degradation of the tetrahedral intermediate composed of a calcium coordinated
1039:. The role of calcium can also be duplicated by other relatively small cations like cobalt and nickel. Before becoming active in digestion, the proform of PLA
996:
water via a bridging second water molecule, w6. It has been suggested that two water molecules are necessary to traverse the distance between the catalytic
984:
is initiated by a His-48/Asp-99/calcium complex within the active site. The calcium ion polarizes the sn-2 carbonyl oxygen while also coordinating with a
3250:
362:
350:
3411:
230:
3068:
1220:
In the case of an inflammation, the application of glucocorticoids up-regulate (mediated at the gene level) the production of the protein
3507:
2830:
1065:. Calcium ion (pink) coordinates with phosphate (light blue). Phosphate mimics tetrahedral intermediate blocking substrate access to
549:
enzymes are commonly found in mammalian tissues as well as arachnid, insect, and snake venom. Venom from bees is largely composed of
3218:
2282:
Six DA, Dennis EA (October 2000). "The expanding superfamily of phospholipase A(2) enzymes: classification and characterization".
1244:'s conversion into proinflammatory mediators and its reincorporation into the membrane. In the absence of strict regulation of PLA
3235:
1458:
947:
223:
3482:
2823:
3868:
330:
426:
174:
3396:
2725:
Bell JG, MacKinlay EE, Dick JR, MacDonald DJ, Boyle RM, Glen AC (October 2004). "Essential fatty acids and phospholipase A
3497:
3491:
3292:
3042:
2468:
Pan YH, Epstein TM, Jain MK, Bahnson BJ (January 2001). "Five coplanar anion binding sites on one face of phospholipase A
2420:
Berg OG, Gelb MH, Tsai MD, Jain MK (September 2001). "Interfacial enzymology: the secreted phospholipase A(2)-paradigm".
1984:(GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor"
1896:
De Luca D, Minucci A, Cogo P, Capoluongo ED, Conti G, Pietrini D, et al. (January 2011). "Secretory phospholipase AA
780:
964:
in atherosclerosis may depend on its carrier in plasma, and several lines of evidence suggest that HDL-associated Lp-PLA
3340:
3009:
3451:
3240:
2965:
2662:
1680:
1331:
1198:
822:
2682:
activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders".
1134:
action can release histamine from rat peritoneal mast cells. It also causes histamine release in human basophils.
3558:
3446:
3367:
3277:
3230:
2815:
1203:
168:
150:
836:, that have no phospholipase activity with typical phospholipase substrate. The lack of enzymatic activity of
414:
3789:
3730:
2988:
155:
3834:
3401:
3391:
2933:
570:
848:
null mice, VLDL levels were greatly reduced, suggesting it could have an effect in lipoprotein secretion.
3794:
3686:
3311:
2969:
235:
3380:
3376:
3372:
3288:
3121:
1273:
1032:
410:
143:
3548:
3104:
2921:
2035:"sPLA2-IIa amplifies ocular surface inflammation in the experimental dry eye (DE) BALB/c mouse model"
1248:
activity, a disproportionate amount of proinflammatory mediators are produced. The resulting induced
1214:
1209:
619:
with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A
343:
78:
2082:
Chalbot S, Zetterberg H, Blennow K, Fladby T, Andreasen N, Grundke-Iqbal I, Iqbal K (January 2011).
1296:
could be a pharmaceutical approach to treatment of several disorders associated with neural trauma.
3296:
3145:
3059:
2993:
2976:
2928:
2809:
744:
511:
61:
171:
3165:
3035:
2983:
1481:
776:
772:
95:
1437:
1431:
1425:
1391:
1385:
1373:
1276:(PAF). Abnormal levels of potent PAF are also associated with neurological damage. An optimal
3721:
3360:
2947:
1399:
1308:
1253:
814:
3656:
3553:
3345:
3306:
3170:
3092:
2940:
2884:
1500:
1147:
768:
569:
disproportionately. As a result, inflammation and pain occur at the site. There are also
566:
515:
2805:
2133:"Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol"
1798:
Escoffier J, Jemel I, Tanemoto A, Taketomi Y, Payre C, Coatrieux C, et al. (May 2010).
1272:
are another class of molecules released from the membrane that are upstream predecessors of
3839:
3674:
3669:
3602:
3262:
3087:
2144:
2131:
Aljakna A, Choi S, Savage H, Hageman Blair R, Gu T, Svenson KL, et al. (August 2012).
1312:
1304:
393:
2507:
Choi SH, Sakamoto T, Fukutomi O, Inagaki N, Matsuura N, Nagai H, Koda A (September 1989).
2325:
Wilensky RL, Shi Y, Mohler ER, Hamamdzic D, Burgert ME, Li J, et al. (October 2008).
1307:
that rises during inflammation, which is also seen to be exponentially higher in low back
771:, and has been shown to promote vascular inflammation correlating with coronary events in
131:
8:
3694:
3664:
3468:
3463:
3387:
3323:
3109:
1628:
activity by mastoparans, a new class of mast cell degranulating peptides from wasp venom"
810:
73:
2148:
107:
3827:
3679:
3160:
3150:
3028:
2707:
2678:
Farooqui AA, Ong WY, Horrocks LA (September 2006). "Inhibitors of brain phospholipase A
2581:
2569:
2355:
2326:
2307:
2259:
2230:
2167:
2132:
2108:
2083:
2059:
2034:
2010:
1979:
1925:
1828:
1799:
1775:
1746:
1722:
1697:
1669:
1261:
900:
818:
66:
2378:
Tellis CC, Tselepis AD (May 2009). "The role of lipoprotein-associated phospholipase A
2295:
1873:
1852:
1644:
1623:
1554:
1533:
355:
186:
3628:
3573:
3541:
3416:
3135:
2785:
2746:
2699:
2658:
2626:
2573:
2534:
2489:
2458:
2437:
2399:
2360:
2299:
2264:
2211:
2172:
2113:
2064:
2015:
1960:
1917:
1878:
1833:
1780:
1727:
1696:
Oliveira AL, Viegas MF, da Silva SL, Soares AM, Ramos MJ, Fernandes PA (2022-06-10).
1676:
1649:
1604:
1559:
1119:
873:
401:
335:
162:
2585:
2311:
1978:
Henderson WR, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH (August 2011).
1929:
1900:
pathway during pediatric acute respiratory distress syndrome: a preliminary study".
1745:
Sato H, Taketomi Y, Isogai Y, Miki Y, Yamamoto K, Masuda S, et al. (May 2010).
299:
3704:
3284:
3184:
3140:
2850:
2777:
2738:
2711:
2691:
2616:
2565:
2524:
2481:
2429:
2391:
2350:
2342:
2291:
2254:
2246:
2203:
2162:
2152:
2103:
2095:
2054:
2046:
2005:
1995:
1952:
1909:
1868:
1823:
1815:
1770:
1762:
1717:
1709:
1639:
1594:
1549:
1285:
1277:
1269:
1249:
1241:
1062:
1009:
896:
756:
683:
585:
562:
527:
507:
389:
1804:
is released during sperm acrosome reaction and controls fertility outcome in mice"
728:
are involved in sperm maturation, and group X are thought to be involved in sperm
367:
3806:
3620:
3536:
3531:
3526:
3439:
3434:
3194:
3072:
2879:
2395:
2157:
1956:
1913:
1155:
989:
957:
760:
600:
596:
592:
311:
45:
3020:
2845:
2742:
190:
3779:
3774:
3769:
3155:
3130:
3126:
3099:
3082:
2902:
1713:
1577:
Nicolas JP, Lin Y, Lambeau G, Ghomashchi F, Lazdunski M, Gelb MH (March 1997).
1492:
1189:
888:
616:
581:
519:
206:
3862:
3520:
3429:
3179:
2621:
2600:
1327:
1103:
920:
912:
865:
759:. This arachidonic acid is then metabolized to form several inflammatory and
748:
656:
535:
485:
181:
2099:
2000:
1599:
1578:
3647:
3578:
3301:
3222:
2789:
2750:
2703:
2529:
2508:
2493:
2441:
2403:
2364:
2303:
2268:
2215:
2176:
2117:
2068:
2033:
Wei Y, Epstein SP, Fukuoka S, Birmingham NP, Li XM, Asbell PA (July 2011).
2019:
1964:
1921:
1882:
1837:
1784:
1731:
1289:
1170:-505. When phosphorylation is coupled with an influx of calcium ions, cPLA
892:
740:
729:
523:
499:
461:
2781:
2630:
2577:
2538:
2284:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
1857:₂ in cardiovascular disease: roles as biological effectors and biomarkers"
1653:
1608:
1563:
339:
3822:
3593:
3487:
3350:
3316:
3254:
2957:
2250:
2050:
1513:
1316:
1099:
1066:
916:
908:
784:
752:
668:
542:, which are categorized as anti-inflammatory and inflammatory mediators.
539:
36:
Phospholipase cleavage sites. Note that an enzyme that displays both PLA
903:
and the precursor for the synthesis of other signaling molecules termed
3799:
2894:
2854:
2846:
2764:
Law MH, Cotton RG, Berger GE (June 2006). "The role of phospholipases A
2084:"Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease"
1942:
1221:
1021:
1013:
904:
531:
503:
465:
457:
323:
119:
2695:
2485:
2462:
2433:
2207:
1534:"Diversity of group types, regulation, and function of phospholipase A
840:
indicates that it may have unique function distinctive from other sPLA
639:), also known as platelet activating factor acetylhydrolase (PAF-AH).
3712:
3511:
3424:
3051:
2382:
in atherosclerosis may depend on its lipoprotein carrier in plasma".
2231:"Hepatocyte nuclear factor 4α and downstream secreted phospholipase A
1819:
1766:
1488:
In addition, the following human proteins contain the phospholipase A
1175:
1070:
1059:
997:
993:
985:
977:
881:
710:
2552:
Morita Y, Aida N, Miyamoto T (August 1983). "Role of phospholipase A
2346:
1252:
and neuroinflammation is analogous to neurological diseases such as
968:
may substantially contribute to the HDL antiatherogenic activities.
3757:
3752:
3747:
3568:
3203:
3055:
1475:
1265:
1257:
1111:
1036:
1005:
695:
687:
672:
550:
469:
306:
2229:
Li X, Jiang H, Qu L, Yao W, Cai H, Chen L, Peng T (January 2014).
31:
3764:
3742:
3737:
3355:
1579:"Localization of structural elements of bee venom phospholipase A
1467:
1419:
1413:
1407:
1379:
1367:
1359:
1350:
1326:
has also been associated with neuropsychiatric disorders such as
1107:
799:
717:. Venom phospholipases help to immobilize prey by promoting cell
699:
318:
138:
1174:
becomes stimulated and can translocate to the membrane to begin
821:, and may serve as a marker of increases in permeability of the
3784:
3717:
3610:
3208:
3116:
2858:
1452:
1445:
1335:
1167:
1122:
that are influential in regulation and stable protein folding.
1050:
795:
691:
680:
421:
218:
114:
102:
90:
2130:
2081:
1797:
3726:
3477:
3473:
2912:
2907:
1017:
1016:
substitution for His-48 maintains wild-type activity, as the
1001:
794:
have been associated with inflammation thought to exacerbate
718:
664:
2331:
reduces complex coronary atherosclerotic plaque development"
1895:
1751:
regulates epididymal sperm maturation and fertility in mice"
1695:
1079:
3458:
3335:
3328:
3272:
3267:
2506:
2032:
1576:
1185:
may be a result of ligand binding to receptors, including:
1163:
956:
are associated with cardiac disease, and may contribute to
676:
495:
383:
294:
126:
2724:
2513:-induced histamine release from rat peritoneal mast cells"
2324:
2235:
GXIIB regulate production of infectious hepatitis C virus"
1977:
1698:"The chemistry of snake venom and its medicinal potential"
1098:
can also be characterized as having a channel featuring a
899:
from membrane phospholipids. Arachidonic acid is both a
714:
933:
2731:
Prostaglandins, Leukotrienes, and
Essential Fatty Acids
2601:"Properties and regulation of cytosolic phospholipase A
2556:
activation in histamine release from human basophils".
259:
2655:
Medical
Physiology: A Cellular And Molecular Approaoch
1945:
International
Journal of Pediatric Otorhinolaryngology
1744:
1583:
involved in N-type receptor binding and neurotoxicity"
1231:
1114:
serve to bind the substrate. Another component of PLA
1102:
wall in which hydrophobic amino acid residues such as
851:
468:
the bond between the second fatty acid "tail" and the
2467:
2327:"Inhibition of lipoprotein-associated phospholipase A
1853:"Lipoprotein-associated and secreted phospholipases A
642:
1073:-48, Asp-99, and two water molecules are also shown.
557:. Due to the increased presence and activity of PLA
2677:
1980:"Blockade of human group X secreted phospholipase A
1850:
2551:
1668:
1666:
3346:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
3050:
1338:), though the mechanisms involved are not known.
872:are also Ca-dependent, but they have a different
828:There are atypical members of the phospholipase A
3860:
2419:
2039:Investigative Ophthalmology & Visual Science
1284:activity on neural cell membranes already under
2763:
1851:Mallat Z, Lambeau G, Tedgui A (November 2010).
743:in mammals by catalyzing the first step of the
480:O = 1-acylglycerophosphocholine + a carboxylate
2377:
1621:
1150:, regulation of the enzyme is essential. cPLA
930:can be classified based on sequence homology.
876:and are significantly larger than secreted PLA
3036:
2831:
2189:
1675:(4th ed.). San Francisco: W.H. Freeman.
2415:
2413:
2228:
2026:
1008:of His-48 is thought to be enhanced through
2648:
2646:
2644:
2642:
2640:
2500:
1889:
1844:
623:. Other families include Ca independent PLA
3043:
3029:
2838:
2824:
1240:regulation accounts for a balance between
258:
30:
2808:at the U.S. National Library of Medicine
2620:
2528:
2509:"Pharmacological study of phospholipase A
2410:
2354:
2281:
2258:
2166:
2156:
2107:
2058:
2009:
1999:
1872:
1827:
1774:
1721:
1643:
1598:
1553:
880:(more than 700 residues). They include a
530:is modified into active compounds called
2637:
1292:. Thus, specific inhibitors of brain PLA
1083:Mechanism of hydrolysis catalyzed by PLA
1078:
1049:
988:water molecule, w5. His-48 improves the
915:. Some eicosanoids are synthesized from
3236:Ubiquitin carboxy-terminal hydrolase L1
1667:Cox M, Nelson DR, Lehninger AL (2005).
1622:Argiolas A, Pisano JJ (November 1983).
1315:. It is a mixture of inflammation and
948:Lipoprotein-associated phospholipase A2
561:resulting from a snake or insect bite,
3861:
2598:
2472:: relationship to interface binding".
1531:
1228:and reduce the inflammatory response.
3816:either deoxy- or ribo-
3024:
2819:
2652:
1808:The Journal of Clinical Investigation
1755:The Journal of Clinical Investigation
1125:
887:These phospholipases are involved in
713:of phospholipid compounds in dietary
3397:Protein serine/threonine phosphatase
1671:Lehninger principles of biochemistry
767:is thought to contribute to several
679:), and from virtually every studied
3498:Cyclic nucleotide phosphodiesterase
3492:Clostridium perfringens alpha toxin
3293:Tartrate-resistant acid phosphatase
2609:The Journal of Biological Chemistry
2275:
1988:The Journal of Biological Chemistry
1747:"Group III secreted phospholipase A
1632:The Journal of Biological Chemistry
1587:The Journal of Biological Chemistry
1542:The Journal of Biological Chemistry
1232:Relevance in neurological disorders
781:acute respiratory distress syndrome
518:. Upon downstream modification by
454:phosphatidylcholine 2-acylhydrolase
13:
3341:Pyruvate dehydrogenase phosphatase
2657:. Elsevier/Saunders. p. 103.
2570:10.1111/j.1398-9995.1983.tb05084.x
790:In children, excess levels of sPLA
663:have been isolated from different
14:
3880:
3241:4-hydroxybenzoyl-CoA thioesterase
2966:5-Lipoxygenase activating protein
2799:
2729:in autistic spectrum disorders".
1874:10.1161/CIRCULATIONAHA.110.936393
1332:pervasive developmental disorders
1158:and calcium concentrations. cPLA
823:blood-cerebrospinal fluid barrier
798:and ocular surface inflammation (
1902:Pediatric Critical Care Medicine
1624:"Facilitation of phospholipase A
1024:can also function to lower the p
923:by phospholipase C (see below).
763:molecules. Excess levels of sPLA
751:, resulting in the formation of
631:) and lipoprotein-associated PLA
3559:N-acetylglucosamine-6-sulfatase
3447:Sphingomyelin phosphodiesterase
2757:
2718:
2671:
2592:
2545:
2517:Journal of Pharmacobio-Dynamics
2451:
2371:
2318:
2222:
2183:
2124:
2075:
1971:
1936:
1319:that are responsible for pain.
3368:Inositol-phosphate phosphatase
3231:Palmitoyl protein thioesterase
2088:Journal of Alzheimer's Disease
1791:
1738:
1689:
1660:
1615:
1570:
1525:
884:and a large catalytic domain.
1:
3731:RNA-induced silencing complex
2989:Gamma-glutamyl transpeptidase
2977:LTA4 hydrolase (B4 synthesis)
2384:Biochimica et Biophysica Acta
2296:10.1016/S1388-1981(00)00105-0
1645:10.1016/S0021-9258(17)43973-1
1555:10.1016/S0021-9258(17)36794-7
1519:
1280:would specifically target PLA
1137:
960:. However, the role of Lp-PLA
553:, which is a stimulant of PLA
378:Available protein structures:
3869:Peripheral membrane proteins
3835:Serratia marcescens nuclease
3402:Dual-specificity phosphatase
3392:Protein tyrosine phosphatase
2934:Prostaglandin-E2 9-reductase
2396:10.1016/j.bbalip.2009.02.015
2158:10.1371/journal.pone.0043139
1957:10.1016/j.ijporl.2011.12.026
1914:10.1097/PCC.0b013e3181dbe95e
1142:Due to the importance of PLA
980:mechanism of pancreatic sPLA
971:
844:. It has been shown that in
809:activity is observed in the
488:specifically recognizes the
456:) catalyses the cleavage of
7:
3312:Fructose 1,6-bisphosphatase
2970:Arachidonate 5-lipoxygenase
2743:10.1016/j.plefa.2004.03.008
1507:
1341:
1299:Increase in phospholipase A
1274:platelet activating factors
606:
16:Peripheral membrane protein
10:
3885:
1714:10.1038/s41570-022-00393-7
1236:In normal brain cells, PLA
1033:acid dissociation constant
952:Increased levels of Lp-PLA
945:
934:Lipoprotein-associated PLA
852:Cytosolic phospholipases A
779:, and possibly leading to
739:has been shown to promote
615:include several unrelated
3815:
3703:
3655:
3641:
3619:
3601:
3587:
3567:
3549:Galactosamine-6 sulfatase
3506:
3410:
3249:
3217:
3105:6-phosphogluconolactonase
3067:
3002:
2956:
2893:
2865:
1702:Nature Reviews. Chemistry
1322:Increased phospholipase A
1054:Close-up rendering of PLA
1043:is activated by trypsin.
659:forms of phospholipases A
643:Secreted phospholipases A
420:
400:
382:
377:
373:
361:
349:
329:
317:
305:
293:
285:
280:
264:Bee venom phospholipase A
257:
249:
229:
217:
205:
200:
196:
180:
161:
149:
137:
125:
113:
101:
89:
84:
72:
60:
55:
29:
21:
3297:Purple acid phosphatases
2810:Medical Subject Headings
2622:10.1074/jbc.272.27.16709
1800:"Group X phospholipase A
745:arachidonic acid pathway
534:. Eicosanoids include
512:lysophosphatidyl choline
2684:Pharmacological Reviews
2599:Leslie CC (July 1997).
2100:10.3233/JAD-2011-101959
2001:10.1074/jbc.M111.235812
1600:10.1074/jbc.272.11.7173
1181:Phosphorylation of cPLA
1162:is phosphorylated by a
777:acute coronary syndrome
773:coronary artery disease
724:In mice, group III sPLA
476:phosphatidylcholine + H
44:activities is called a
3722:Microprocessor complex
3361:Beta-propeller phytase
2530:10.1248/bpb1978.12.517
1532:Dennis EA (May 1994).
1224:which may inhibit cPLA
1148:inflammatory responses
1087:
1074:
709:serve for the initial
3657:Endodeoxyribonuclease
3554:Iduronate-2-sulfatase
3307:Glucose 6-phosphatase
3093:Butyrylcholinesterase
2885:Diacylglycerol lipase
2782:10.1038/sj.mp.4001819
1346:Human phospholipase A
1082:
1053:
893:inflammatory response
769:inflammatory diseases
567:phospholipid membrane
565:is released from the
516:lysophosphatidic acid
3840:Micrococcal nuclease
3675:Deoxyribonuclease IV
3670:Deoxyribonuclease II
3603:Exodeoxyribonuclease
3263:Alkaline phosphatase
3088:Acetylcholinesterase
2770:Molecular Psychiatry
2251:10.1128/JVI.02068-13
2051:10.1167/iovs.10-6350
1313:rheumatoid arthritis
1305:acute-phase reaction
1020:functional group on
919:, released from the
580:Additional types of
506:the bond, releasing
3695:UvrABC endonuclease
3665:Deoxyribonuclease I
3388:Protein phosphatase
3324:Protein phosphatase
3122:Bile salt-dependent
3110:PAF acetylhydrolase
2768:in schizophrenia".
2615:(27): 16709–16712.
2239:Journal of Virology
2149:2012PLoSO...743139A
1994:(32): 28049–28055.
1638:(22): 13697–13702.
1548:(18): 13057–13060.
1254:Alzheimer's disease
891:processes, such as
815:Alzheimer's disease
811:cerebrospinal fluid
783:and progression of
3828:Mung bean nuclease
3687:Restriction enzyme
3680:Restriction enzyme
1262:multiple sclerosis
1126:Biological effects
1088:
1075:
901:signaling molecule
819:multiple sclerosis
694:) as well as from
502:and catalytically
452:, systematic name
3856:
3855:
3852:
3851:
3848:
3847:
3637:
3636:
3629:Oligonucleotidase
3574:deoxyribonuclease
3542:Steroid sulfatase
3417:Phosphodiesterase
3146:Hormone-sensitive
3018:
3017:
2696:10.1124/pr.58.3.7
2653:Boron WF (2003).
2486:10.1021/bi002514g
2434:10.1021/cr990139w
2341:(10): 1059–1066.
2208:10.1002/hep.24066
1867:(21): 2183–2200.
1593:(11): 7173–7181.
1270:Lysophospholipids
1120:disulfide bridges
1092:
1091:
1058:active site with
1012:with Asp-99. An
747:by breaking down
514:, a precursor of
460:in position 2 of
436:
435:
432:
431:
427:structure summary
275:
245:
244:
241:
240:
144:metabolic pathway
3876:
3705:Endoribonuclease
3691:
3685:
3653:
3652:
3599:
3598:
3585:
3584:
3285:Acid phosphatase
3166:Monoacylglycerol
3076:ester hydrolases
3045:
3038:
3031:
3022:
3021:
2873:Phospholipase A2
2851:lipid metabolism
2840:
2833:
2826:
2817:
2816:
2806:Phospholipase+A2
2794:
2793:
2761:
2755:
2754:
2722:
2716:
2715:
2675:
2669:
2668:
2650:
2635:
2634:
2624:
2596:
2590:
2589:
2549:
2543:
2542:
2532:
2504:
2498:
2497:
2465:
2455:
2449:
2448:
2428:(9): 2613–2654.
2422:Chemical Reviews
2417:
2408:
2407:
2375:
2369:
2368:
2358:
2322:
2316:
2315:
2279:
2273:
2272:
2262:
2226:
2220:
2219:
2187:
2181:
2180:
2170:
2160:
2128:
2122:
2121:
2111:
2079:
2073:
2072:
2062:
2045:(7): 4780–4788.
2030:
2024:
2023:
2013:
2003:
1975:
1969:
1968:
1940:
1934:
1933:
1893:
1887:
1886:
1876:
1848:
1842:
1841:
1831:
1820:10.1172/JCI40494
1814:(5): 1415–1428.
1795:
1789:
1788:
1778:
1767:10.1172/JCI40493
1761:(5): 1400–1414.
1742:
1736:
1735:
1725:
1693:
1687:
1686:
1674:
1664:
1658:
1657:
1647:
1619:
1613:
1612:
1602:
1574:
1568:
1567:
1557:
1529:
1309:disc herniations
1286:oxidative stress
1278:enzyme inhibitor
1250:oxidative stress
1242:arachidonic acid
1154:is regulated by
1063:enzyme inhibitor
1046:
1045:
1010:hydrogen bonding
926:Phospholipases A
907:. These include
897:arachidonic acid
832:family, such as
757:arachidonic acid
698:. They require
617:protein families
611:Phospholipases A
563:arachidonic acid
528:arachidonic acid
508:arachidonic acid
484:This particular
375:
374:
273:
262:
247:
246:
198:
197:
34:
19:
18:
3884:
3883:
3879:
3878:
3877:
3875:
3874:
3873:
3859:
3858:
3857:
3844:
3811:
3699:
3689:
3683:
3646:
3633:
3621:Exoribonuclease
3615:
3592:
3576:
3572:
3563:
3537:Arylsulfatase L
3532:Arylsulfatase B
3527:Arylsulfatase A
3502:
3415:
3406:
3245:
3213:
3075:
3063:
3049:
3019:
3014:
2998:
2952:
2889:
2880:Phospholipase C
2861:
2844:
2802:
2797:
2767:
2762:
2758:
2728:
2723:
2719:
2681:
2676:
2672:
2665:
2651:
2638:
2604:
2597:
2593:
2555:
2550:
2546:
2512:
2505:
2501:
2471:
2457:
2456:
2452:
2418:
2411:
2381:
2376:
2372:
2347:10.1038/nm.1870
2335:Nature Medicine
2330:
2323:
2319:
2280:
2276:
2234:
2227:
2223:
2193:
2188:
2184:
2129:
2125:
2080:
2076:
2031:
2027:
1983:
1976:
1972:
1941:
1937:
1899:
1894:
1890:
1856:
1849:
1845:
1803:
1796:
1792:
1750:
1743:
1739:
1694:
1690:
1683:
1665:
1661:
1627:
1620:
1616:
1582:
1575:
1571:
1537:
1530:
1526:
1522:
1510:
1491:
1349:
1344:
1325:
1303:activity is an
1302:
1295:
1283:
1247:
1239:
1234:
1227:
1193:
1184:
1173:
1161:
1156:phosphorylation
1153:
1145:
1140:
1133:
1128:
1117:
1097:
1086:
1057:
1042:
1030:
990:nucleophilicity
983:
974:
967:
963:
958:atherosclerosis
955:
950:
944:
941:
937:
929:
895:. They release
879:
871:
862:
859:
855:
843:
831:
813:of humans with
808:
793:
766:
738:
727:
708:
705:Pancreatic sPLA
662:
653:
650:
646:
638:
634:
630:
626:
622:
614:
609:
601:phospholipase D
597:phospholipase C
593:phospholipase B
589:
586:phospholipase A
574:
560:
556:
548:
520:cyclooxygenases
494:
479:
450:
443:
440:phospholipase A
351:OPM superfamily
289:Phospholip_A2_1
276:
271:
267:
253:
250:Phospholipase A
51:
46:phospholipase B
43:
39:
25:
22:phospholipase A
17:
12:
11:
5:
3882:
3872:
3871:
3854:
3853:
3850:
3849:
3846:
3845:
3843:
3842:
3837:
3832:
3831:
3830:
3819:
3817:
3813:
3812:
3810:
3809:
3804:
3803:
3802:
3797:
3792:
3787:
3777:
3772:
3767:
3762:
3761:
3760:
3755:
3750:
3745:
3735:
3734:
3733:
3724:
3709:
3707:
3701:
3700:
3698:
3697:
3692:
3677:
3672:
3667:
3661:
3659:
3650:
3639:
3638:
3635:
3634:
3632:
3631:
3625:
3623:
3617:
3616:
3614:
3613:
3607:
3605:
3596:
3582:
3565:
3564:
3562:
3561:
3556:
3551:
3546:
3545:
3544:
3539:
3534:
3529:
3516:
3514:
3504:
3503:
3501:
3500:
3495:
3485:
3480:
3471:
3466:
3461:
3456:
3455:
3454:
3444:
3443:
3442:
3437:
3427:
3421:
3419:
3408:
3407:
3405:
3404:
3399:
3394:
3385:
3384:
3383:
3365:
3364:
3363:
3353:
3348:
3343:
3338:
3333:
3332:
3331:
3321:
3320:
3319:
3309:
3304:
3299:
3282:
3281:
3280:
3275:
3270:
3259:
3257:
3247:
3246:
3244:
3243:
3238:
3233:
3227:
3225:
3215:
3214:
3212:
3211:
3206:
3200:
3199:
3198:
3197:
3192:
3187:
3176:
3175:
3174:
3173:
3171:Diacylglycerol
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3124:
3113:
3112:
3107:
3102:
3100:Pectinesterase
3097:
3096:
3095:
3090:
3083:Cholinesterase
3079:
3077:
3065:
3064:
3048:
3047:
3040:
3033:
3025:
3016:
3015:
3013:
3012:
3006:
3004:
3000:
2999:
2997:
2996:
2994:LTD4 hydrolase
2991:
2986:
2980:
2979:
2973:
2972:
2962:
2960:
2954:
2953:
2951:
2950:
2944:
2943:
2937:
2936:
2931:
2925:
2924:
2918:
2917:
2916:
2915:
2910:
2903:Cyclooxygenase
2899:
2897:
2891:
2890:
2888:
2887:
2882:
2876:
2875:
2869:
2867:
2863:
2862:
2843:
2842:
2835:
2828:
2820:
2814:
2813:
2801:
2800:External links
2798:
2796:
2795:
2776:(6): 547–556.
2765:
2756:
2737:(4): 201–204.
2726:
2717:
2690:(3): 591–620.
2679:
2670:
2663:
2636:
2602:
2591:
2564:(6): 413–418.
2553:
2544:
2523:(9): 517–522.
2510:
2499:
2480:(3): 609–617.
2469:
2450:
2409:
2390:(5): 327–338.
2379:
2370:
2328:
2317:
2274:
2245:(1): 612–627.
2232:
2221:
2202:(2): 458–466.
2191:
2182:
2123:
2094:(3): 505–515.
2074:
2025:
1981:
1970:
1951:(4): 471–474.
1935:
1908:(1): e20–e24.
1897:
1888:
1854:
1843:
1801:
1790:
1748:
1737:
1708:(7): 451–469.
1688:
1681:
1659:
1625:
1614:
1580:
1569:
1535:
1523:
1521:
1518:
1517:
1516:
1509:
1506:
1505:
1504:
1489:
1486:
1485:
1471:
1463:
1455:
1449:
1441:
1403:
1395:
1363:
1347:
1343:
1340:
1323:
1300:
1293:
1281:
1245:
1237:
1233:
1230:
1225:
1218:
1217:
1215:IFN-γ receptor
1212:
1210:IFN-α receptor
1207:
1201:
1196:
1191:
1182:
1171:
1159:
1151:
1143:
1139:
1136:
1131:
1127:
1124:
1115:
1095:
1090:
1089:
1084:
1076:
1055:
1040:
1028:
981:
976:The suggested
973:
970:
965:
961:
953:
946:Main article:
943:
939:
935:
932:
927:
917:diacylglycerol
913:prostaglandins
889:cell signaling
877:
869:
868:, group IV PLA
861:
857:
853:
850:
841:
829:
806:
805:Increased sPLA
791:
764:
736:
725:
706:
702:for activity.
660:
652:
648:
644:
641:
636:
632:
628:
624:
620:
612:
608:
605:
587:
582:phospholipases
575:phospholipases
572:
558:
554:
546:
536:prostaglandins
492:
482:
481:
477:
448:
441:
434:
433:
430:
429:
424:
418:
417:
404:
398:
397:
387:
380:
379:
371:
370:
365:
359:
358:
353:
347:
346:
333:
327:
326:
321:
315:
314:
309:
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302:
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291:
290:
287:
283:
282:
278:
277:
269:
265:
263:
255:
254:
251:
243:
242:
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214:
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203:
202:
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166:
159:
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147:
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135:
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117:
111:
110:
105:
99:
98:
93:
87:
86:
82:
81:
76:
70:
69:
64:
58:
57:
53:
52:
41:
37:
35:
27:
26:
23:
15:
9:
6:
4:
3:
2:
3881:
3870:
3867:
3866:
3864:
3841:
3838:
3836:
3833:
3829:
3826:
3825:
3824:
3821:
3820:
3818:
3814:
3808:
3805:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3782:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3740:
3739:
3736:
3732:
3728:
3725:
3723:
3719:
3716:
3715:
3714:
3711:
3710:
3708:
3706:
3702:
3696:
3693:
3688:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3662:
3660:
3658:
3654:
3651:
3649:
3644:
3640:
3630:
3627:
3626:
3624:
3622:
3618:
3612:
3609:
3608:
3606:
3604:
3600:
3597:
3595:
3590:
3586:
3583:
3580:
3575:
3570:
3566:
3560:
3557:
3555:
3552:
3550:
3547:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3524:
3523:
3522:
3521:arylsulfatase
3518:
3517:
3515:
3513:
3509:
3505:
3499:
3496:
3493:
3489:
3486:
3484:
3481:
3479:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3453:
3450:
3449:
3448:
3445:
3441:
3438:
3436:
3433:
3432:
3431:
3430:Phospholipase
3428:
3426:
3423:
3422:
3420:
3418:
3413:
3409:
3403:
3400:
3398:
3395:
3393:
3389:
3386:
3382:
3378:
3374:
3371:
3370:
3369:
3366:
3362:
3359:
3358:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3330:
3327:
3326:
3325:
3322:
3318:
3315:
3314:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3294:
3290:
3286:
3283:
3279:
3276:
3274:
3271:
3269:
3266:
3265:
3264:
3261:
3260:
3258:
3256:
3252:
3248:
3242:
3239:
3237:
3234:
3232:
3229:
3228:
3226:
3224:
3220:
3216:
3210:
3207:
3205:
3202:
3201:
3196:
3193:
3191:
3188:
3186:
3183:
3182:
3181:
3180:Phospholipase
3178:
3177:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3128:
3125:
3123:
3120:
3119:
3118:
3115:
3114:
3111:
3108:
3106:
3103:
3101:
3098:
3094:
3091:
3089:
3086:
3085:
3084:
3081:
3080:
3078:
3074:
3070:
3066:
3061:
3057:
3053:
3046:
3041:
3039:
3034:
3032:
3027:
3026:
3023:
3011:
3008:
3007:
3005:
3001:
2995:
2992:
2990:
2987:
2985:
2984:LTC4 synthase
2982:
2981:
2978:
2975:
2974:
2971:
2967:
2964:
2963:
2961:
2959:
2955:
2949:
2946:
2945:
2942:
2941:PGI2 synthase
2939:
2938:
2935:
2932:
2930:
2927:
2926:
2923:
2922:PGD2 synthase
2920:
2919:
2914:
2911:
2909:
2906:
2905:
2904:
2901:
2900:
2898:
2896:
2892:
2886:
2883:
2881:
2878:
2877:
2874:
2871:
2870:
2868:
2864:
2860:
2856:
2852:
2848:
2841:
2836:
2834:
2829:
2827:
2822:
2821:
2818:
2811:
2807:
2804:
2803:
2791:
2787:
2783:
2779:
2775:
2771:
2760:
2752:
2748:
2744:
2740:
2736:
2732:
2721:
2713:
2709:
2705:
2701:
2697:
2693:
2689:
2685:
2674:
2666:
2664:1-4160-2328-3
2660:
2656:
2649:
2647:
2645:
2643:
2641:
2632:
2628:
2623:
2618:
2614:
2610:
2606:
2595:
2587:
2583:
2579:
2575:
2571:
2567:
2563:
2559:
2548:
2540:
2536:
2531:
2526:
2522:
2518:
2514:
2503:
2495:
2491:
2487:
2483:
2479:
2475:
2464:
2460:
2454:
2447:
2446:See page 2640
2443:
2439:
2435:
2431:
2427:
2423:
2416:
2414:
2405:
2401:
2397:
2393:
2389:
2385:
2374:
2366:
2362:
2357:
2352:
2348:
2344:
2340:
2336:
2332:
2321:
2313:
2309:
2305:
2301:
2297:
2293:
2290:(1–2): 1–19.
2289:
2285:
2278:
2270:
2266:
2261:
2256:
2252:
2248:
2244:
2240:
2236:
2225:
2217:
2213:
2209:
2205:
2201:
2197:
2186:
2178:
2174:
2169:
2164:
2159:
2154:
2150:
2146:
2143:(8): e43139.
2142:
2138:
2134:
2127:
2119:
2115:
2110:
2105:
2101:
2097:
2093:
2089:
2085:
2078:
2070:
2066:
2061:
2056:
2052:
2048:
2044:
2040:
2036:
2029:
2021:
2017:
2012:
2007:
2002:
1997:
1993:
1989:
1985:
1974:
1966:
1962:
1958:
1954:
1950:
1946:
1939:
1931:
1927:
1923:
1919:
1915:
1911:
1907:
1903:
1892:
1884:
1880:
1875:
1870:
1866:
1862:
1858:
1847:
1839:
1835:
1830:
1825:
1821:
1817:
1813:
1809:
1805:
1794:
1786:
1782:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1741:
1733:
1729:
1724:
1719:
1715:
1711:
1707:
1703:
1699:
1692:
1684:
1682:0-7167-4339-6
1678:
1673:
1672:
1663:
1655:
1651:
1646:
1641:
1637:
1633:
1629:
1618:
1610:
1606:
1601:
1596:
1592:
1588:
1584:
1573:
1565:
1561:
1556:
1551:
1547:
1543:
1539:
1528:
1524:
1515:
1512:
1511:
1503:
1502:
1498:
1497:
1496:
1494:
1484:
1483:
1478:
1477:
1472:
1470:
1469:
1464:
1462:
1461:
1456:
1454:
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1447:
1442:
1440:
1439:
1434:
1433:
1428:
1427:
1422:
1421:
1416:
1415:
1410:
1409:
1404:
1402:
1401:
1396:
1394:
1393:
1388:
1387:
1382:
1381:
1376:
1375:
1370:
1369:
1364:
1362:
1361:
1356:
1355:
1354:
1352:
1339:
1337:
1333:
1329:
1328:schizophrenia
1320:
1318:
1314:
1310:
1306:
1297:
1291:
1287:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1243:
1229:
1223:
1216:
1213:
1211:
1208:
1205:
1202:
1200:
1197:
1195:
1188:
1187:
1186:
1179:
1177:
1169:
1165:
1157:
1149:
1135:
1123:
1121:
1118:is the seven
1113:
1109:
1105:
1101:
1081:
1077:
1072:
1068:
1064:
1061:
1052:
1048:
1047:
1044:
1038:
1034:
1027:
1023:
1019:
1015:
1011:
1007:
1003:
999:
995:
991:
987:
979:
969:
959:
949:
931:
924:
922:
921:lipid bilayer
918:
914:
910:
906:
902:
898:
894:
890:
885:
883:
875:
867:
866:intracellular
849:
847:
839:
835:
826:
824:
820:
816:
812:
803:
801:
797:
788:
786:
782:
778:
774:
770:
762:
758:
754:
750:
749:phospholipids
746:
742:
733:
731:
722:
720:
716:
712:
703:
701:
697:
693:
689:
685:
682:
678:
674:
670:
666:
658:
657:extracellular
640:
618:
604:
602:
598:
594:
590:
583:
578:
576:
571:prokaryotic A
568:
564:
552:
543:
541:
537:
533:
529:
525:
524:lipoxygenases
521:
517:
513:
509:
505:
501:
500:phospholipids
497:
491:
487:
486:phospholipase
475:
474:
473:
471:
467:
463:
462:phospholipids
459:
455:
451:
445:(EC 3.1.1.4,
444:
428:
425:
423:
419:
416:
412:
408:
405:
403:
399:
395:
391:
388:
385:
381:
376:
372:
369:
366:
364:
360:
357:
354:
352:
348:
345:
341:
337:
334:
332:
328:
325:
322:
320:
316:
313:
310:
308:
304:
301:
298:
296:
292:
288:
284:
279:
261:
256:
248:
237:
234:
232:
228:
225:
222:
220:
216:
213:
210:
208:
204:
199:
195:
192:
188:
185:
183:
182:Gene Ontology
179:
176:
173:
170:
167:
164:
160:
157:
154:
152:
148:
145:
142:
140:
136:
133:
130:
128:
124:
121:
120:NiceZyme view
118:
116:
112:
109:
106:
104:
100:
97:
94:
92:
88:
83:
80:
77:
75:
71:
68:
65:
63:
59:
54:
50:
47:
33:
28:
20:
3690:}}
3684:{{
3648:Endonuclease
3579:ribonuclease
3519:
3302:Nucleotidase
3223:Thioesterase
3189:
2958:Leukotrienes
2948:TXA synthase
2929:PGE synthase
2872:
2773:
2769:
2759:
2734:
2730:
2720:
2687:
2683:
2673:
2654:
2612:
2608:
2594:
2561:
2557:
2547:
2520:
2516:
2502:
2477:
2474:Biochemistry
2473:
2453:
2445:
2425:
2421:
2387:
2383:
2373:
2338:
2334:
2320:
2287:
2283:
2277:
2242:
2238:
2224:
2199:
2195:
2185:
2140:
2136:
2126:
2091:
2087:
2077:
2042:
2038:
2028:
1991:
1987:
1973:
1948:
1944:
1938:
1905:
1901:
1891:
1864:
1860:
1846:
1811:
1807:
1793:
1758:
1754:
1740:
1705:
1701:
1691:
1670:
1662:
1635:
1631:
1617:
1590:
1586:
1572:
1545:
1541:
1527:
1499:
1487:
1480:
1474:
1466:
1459:
1444:
1436:
1430:
1424:
1418:
1412:
1406:
1398:
1390:
1384:
1378:
1372:
1366:
1358:
1345:
1321:
1311:compared to
1298:
1290:inflammation
1235:
1219:
1180:
1141:
1129:
1093:
1025:
975:
951:
925:
909:leukotrienes
886:
874:3D structure
863:
845:
837:
833:
827:
804:
789:
761:thrombogenic
741:inflammation
734:
730:capacitation
723:
704:
654:
610:
579:
544:
540:leukotrienes
489:
483:
453:
446:
439:
437:
108:BRENDA entry
49:
3823:Nuclease S1
3594:Exonuclease
3488:Lecithinase
3317:Calcineurin
3255:Phosphatase
3161:Lipoprotein
3151:Endothelial
2895:Prostanoids
2857:metabolism
1861:Circulation
1514:Paul Sigler
1473:Group XII:
1457:Group VII:
1397:Group III:
1317:substance P
1288:and potent
1100:hydrophobic
1067:active site
905:eicosanoids
785:tonsillitis
753:fatty acids
686:(including
532:eicosanoids
466:hydrolyzing
458:fatty acids
438:The enzyme
363:OPM protein
281:Identifiers
96:IntEnz view
56:Identifiers
3136:Pancreatic
3073:Carboxylic
2855:eicosanoid
2847:Metabolism
2196:Hepatology
1520:References
1451:Group VI:
1405:Group IV:
1365:Group II:
1222:lipocortin
1138:Regulation
1022:asparagine
1014:asparagine
755:including
504:hydrolyzes
472:molecule:
390:structures
165:structures
132:KEGG entry
79:9001-84-7
3713:RNase III
3571:(includes
3512:Sulfatase
3425:Autotaxin
3289:Prostatic
3141:Lysosomal
3056:esterases
3052:Hydrolase
3003:Ungrouped
2866:Precursor
2466:;
1465:Group X:
1443:Group V:
1357:Group I:
1353:include:
1334:(such as
1194:receptors
1176:catalysis
1060:phosphate
998:histidine
994:catalytic
986:catalytic
978:catalytic
972:Mechanism
882:C2 domain
711:digestion
681:mammalian
324:PDOC00109
312:IPR001211
85:Databases
3863:Category
3807:RNase T1
3569:Nuclease
3204:Cutinase
2790:16585943
2751:15301788
2704:16968951
2586:42671016
2494:11170377
2442:11749391
2404:19272461
2365:18806801
2312:23717374
2304:11080672
2269:24173221
2216:21274867
2194:GXIIB".
2177:22912808
2137:PLOS ONE
2118:21471645
2069:21519031
2020:21652694
1965:22297210
1930:36962872
1922:20351613
1883:21098459
1838:20424324
1785:20424323
1732:35702592
1508:See also
1482:PLA2G12B
1476:PLA2G12A
1351:isozymes
1342:Isozymes
1266:ischemia
1258:epilepsy
1206:receptor
1037:oxyanion
1006:basicity
1000:and the
846:PLA2G12B
838:PLA2G12B
834:PLA2G12B
696:bacteria
688:pancreas
607:Families
584:include
551:melittin
498:bond of
470:glycerol
407:RCSB PDB
307:InterPro
236:proteins
224:articles
212:articles
169:RCSB PDB
3780:RNase E
3775:RNase Z
3770:RNase A
3765:RNase P
3738:RNase H
3356:Phytase
3156:Hepatic
3131:Lingual
3127:Gastric
2859:enzymes
2712:6137443
2631:9201969
2578:6194706
2558:Allergy
2539:2482349
2356:2885134
2260:3911757
2168:3422231
2145:Bibcode
2109:3139450
2060:3175946
2011:3151050
1829:2860919
1776:2860917
1723:9185726
1654:6643447
1609:9054413
1564:8175726
1468:PLA2G10
1438:PLA2G4F
1432:PLA2G4E
1426:PLA2G4D
1420:PLA2G4C
1414:PLA2G4B
1408:PLA2G4A
1392:PLA2G2F
1386:PLA2G2E
1380:PLA2G2D
1374:PLA2G2C
1368:PLA2G2A
1360:PLA2G1B
992:of the
938:(Lp-PLA
800:dry eye
635:(Lp-PLA
319:PROSITE
300:PF00068
191:QuickGO
156:profile
139:MetaCyc
74:CAS no.
67:3.1.1.4
40:and PLA
3718:Drosha
3643:3.1.21
3611:RecBCD
3589:3.1.11
3209:PETase
3117:Lipase
2812:(MeSH)
2788:
2749:
2710:
2702:
2661:
2629:
2584:
2576:
2537:
2492:
2440:
2402:
2363:
2353:
2310:
2302:
2267:
2257:
2214:
2175:
2165:
2116:
2106:
2067:
2057:
2018:
2008:
1963:
1928:
1920:
1881:
1836:
1826:
1783:
1773:
1730:
1720:
1679:
1652:
1607:
1562:
1493:domain
1460:PLA2G7
1453:PLA2G6
1446:PLA2G5
1400:PLA2G3
1336:autism
1199:mGLUR1
1168:Serine
1110:, and
1004:. The
796:asthma
692:kidney
684:tissue
675:, and
665:venoms
599:, and
422:PDBsum
396:
386:
344:SUPFAM
286:Symbol
219:PubMed
201:Search
187:AmiGO
175:PDBsum
115:ExPASy
103:BRENDA
91:IntEnz
62:EC no.
3727:Dicer
3682:;see
3508:3.1.6
3478:PDE4B
3474:PDE4A
3412:3.1.4
3381:IMPA3
3377:IMPA2
3373:IMPA1
3251:3.1.3
3219:3.1.2
3069:3.1.1
2913:PTGS2
2908:PTGS1
2708:S2CID
2582:S2CID
2308:S2CID
1926:S2CID
1031:, or
1018:amide
1002:ester
856:(cPLA
719:lysis
669:snake
647:(sPLA
627:(iPLA
340:SCOPe
331:SCOP2
151:PRIAM
3645:-31:
3591:-16:
3577:and
3483:PDE5
3469:PDE3
3464:PDE2
3459:PDE1
3351:PTEN
3336:OCRL
3329:PP2A
3278:ALPP
3273:ALPL
3268:ALPI
3062:3.1)
3010:HPGD
2786:PMID
2747:PMID
2700:PMID
2659:ISBN
2627:PMID
2574:PMID
2535:PMID
2490:PMID
2463:1FXF
2438:PMID
2400:PMID
2388:1791
2361:PMID
2300:PMID
2288:1488
2265:PMID
2212:PMID
2173:PMID
2114:PMID
2065:PMID
2016:PMID
1961:PMID
1918:PMID
1879:PMID
1834:PMID
1781:PMID
1728:PMID
1677:ISBN
1650:PMID
1605:PMID
1560:PMID
1501:OC90
1330:and
1204:bFGF
1190:5-HT
1164:MAPK
911:and
864:The
817:and
775:and
735:sPLA
690:and
677:wasp
655:The
538:and
510:and
496:acyl
415:PDBj
411:PDBe
394:ECOD
384:Pfam
368:1g4i
336:1bbc
295:Pfam
268:sPLA
231:NCBI
172:PDBe
127:KEGG
3800:4/5
2778:doi
2739:doi
2692:doi
2617:doi
2613:272
2566:doi
2525:doi
2482:doi
2459:PDB
2430:doi
2426:101
2392:doi
2351:PMC
2343:doi
2292:doi
2255:PMC
2247:doi
2204:doi
2163:PMC
2153:doi
2104:PMC
2096:doi
2055:PMC
2047:doi
2006:PMC
1996:doi
1992:286
1953:doi
1910:doi
1869:doi
1865:122
1824:PMC
1816:doi
1812:120
1771:PMC
1763:doi
1759:120
1718:PMC
1710:doi
1640:doi
1636:258
1595:doi
1591:272
1550:doi
1546:269
1166:at
1146:in
1130:PLA
1112:Tyr
1108:Leu
1104:Phe
1094:PLA
1071:His
1069:.
802:).
715:fat
673:bee
545:PLA
522:or
447:PLA
402:PDB
207:PMC
163:PDB
3865::
3758:2C
3753:2B
3748:2A
3729::
3720::
3510::
3390::
3379:,
3375:,
3291:)/
3253::
3221::
3190:A2
3185:A1
3071::
3060:EC
3054::
2853:–
2849::
2784:.
2774:11
2772:.
2745:.
2735:71
2733:.
2706:.
2698:.
2688:58
2686:.
2639:^
2625:.
2611:.
2607:.
2580:.
2572:.
2562:38
2560:.
2533:.
2521:12
2519:.
2515:.
2488:.
2478:40
2476:.
2461::
2444:.
2436:.
2424:.
2412:^
2398:.
2386:.
2359:.
2349:.
2339:14
2337:.
2333:.
2306:.
2298:.
2286:.
2263:.
2253:.
2243:88
2241:.
2237:.
2210:.
2200:53
2198:.
2171:.
2161:.
2151:.
2139:.
2135:.
2112:.
2102:.
2092:25
2090:.
2086:.
2063:.
2053:.
2043:52
2041:.
2037:.
2014:.
2004:.
1990:.
1986:.
1959:.
1949:76
1947:.
1924:.
1916:.
1906:12
1904:.
1877:.
1863:.
1859:.
1832:.
1822:.
1810:.
1806:.
1779:.
1769:.
1757:.
1753:.
1726:.
1716:.
1704:.
1700:.
1648:.
1634:.
1630:.
1603:.
1589:.
1585:.
1558:.
1544:.
1540:.
1495::
1479:,
1435:,
1429:,
1423:,
1417:,
1411:,
1389:,
1383:,
1377:,
1371:,
1268:.
1264:,
1260:,
1256:,
1178:.
1106:,
825:.
787:.
732:.
721:.
700:Ca
671:,
603:.
595:,
591:,
577:.
526:,
490:sn
464:,
413:;
409:;
392:/
356:82
342:/
338:/
272:.
189:/
3795:3
3790:2
3785:1
3743:1
3581:)
3494:)
3490:(
3476:/
3452:1
3440:D
3435:C
3414::
3295:/
3287:(
3195:B
3129:/
3058:(
3044:e
3037:t
3030:v
2968:/
2839:e
2832:t
2825:v
2792:.
2780::
2766:2
2753:.
2741::
2727:2
2714:.
2694::
2680:2
2667:.
2633:.
2619::
2605:"
2603:2
2588:.
2568::
2554:2
2541:.
2527::
2511:2
2496:.
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2470:2
2432::
2406:.
2394::
2380:2
2367:.
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2329:2
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2271:.
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2233:2
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2206::
2192:2
2179:.
2155::
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2141:7
2120:.
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2071:.
2049::
2022:.
1998::
1982:2
1967:.
1955::
1932:.
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1898:2
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1706:6
1685:.
1656:.
1642::
1626:2
1611:.
1597::
1581:2
1566:.
1552::
1538:"
1536:2
1490:2
1348:2
1324:2
1301:2
1294:2
1282:2
1246:2
1238:2
1226:2
1192:2
1183:2
1172:2
1160:2
1152:2
1144:2
1132:2
1116:2
1096:2
1085:2
1056:2
1041:2
1029:a
1026:K
982:2
966:2
962:2
954:2
942:)
940:2
936:2
928:2
878:2
870:2
860:)
858:2
854:2
842:2
830:2
807:2
792:2
765:2
737:2
726:2
707:2
667:(
661:2
651:)
649:2
645:2
637:2
633:2
629:2
625:2
621:2
613:2
588:1
573:2
559:2
555:2
547:2
493:2
478:2
449:2
442:2
270:2
266:2
252:2
48:.
42:2
38:1
24:2
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