698:
1986:
675:
597:
572:
6130:
6115:
6100:
5995:
5755:
956:
949:
6160:
6145:
5920:
704:
603:
5935:
6190:
5950:
5785:
5770:
6175:
6085:
5815:
5800:
6070:
6055:
5905:
5890:
5875:
5860:
5845:
5830:
6205:
5980:
5965:
6010:
2281:. (These ovine sites correspond to human sites 133, 151, and 168.) Polymorphisms of the PrP-VRQ form and PrP-ARQ form are associated with increased susceptibility, whereas PrP-ARR is associated with resistance. The National Scrapie Plan of the UK aims to breed out these scrapie polymorphisms by increasing the frequency of the resistant allele. However, PrP-ARR polymorphisms are susceptible to atypical scrapie, so this may prove unfruitful.
6040:
6025:
2581:(the building-blocks of proteins) in the prion protein. Others insert additional amino acids into the protein or cause an abnormally short protein to be made. These mutations cause the cell to make prion proteins with an abnormal structure. The abnormal protein PrP accumulates in the brain and destroys nerve cells, which leads to the mental and behavioral features of prion diseases.
49:
2479:
Modulation of signal transduction pathways has been demonstrated in cross-linking with antibodies and ligand-binding (hop/STI1 or copper). Given the diversity of interactions, effects, and distribution, PrP has been proposed as dynamic surface protein functioning in signaling pathways. Specific sites
2251:
from PrP, but identical primary sequence. Whereas PrP has largely alpha helical and disordered domains, PrP has no alpha helix and an amyloid fibril core composed of a stack of PrP molecules glued together by parallel in-register intermolecular beta sheets. This refolding renders the PrP isoform
2572:
The conversion of PrP to PrP conformation is the mechanism of transmission of fatal, neurodegenerative transmissible spongiform encephalopathies (TSE). This can arise from genetic factors, infection from external source, or spontaneously for reasons unknown. Accumulation of PrP corresponds with
2389:
PrP is present in both the pre- and post-synaptic compartments, with the greatest concentration in the pre-synaptic portion. Considering this and PrP's suite of behavioral influences, the neural cell functions and interactions are of particular interest. Based on the copper ligand, one proposed
2818:
In 2006 the production of cattle lacking PrP form of the major prion protein (PrP) protein was reported which were resistant to prion propagation with no apparent developmental abnormalities. Besides the study of bovine products free of prion proteins another use could be so that human
2735:
models of
Alzheimer's, attenuated the epilepsy-induced death phenotype seen in a subset of these animals. Taken collectively, recent evidence suggests PRNP may be important for conducing the neurotoxic effects of soluble Aβ-oligomers and the emergent disease state of Alzheimer's.
75:
2298:
mice to investigate deficiencies and differences. Initial attempts produced two strains of PrP-null mice that show no physiological or developmental differences when subjected to an array of tests. However, more recent strains have shown significant cognitive abnormalities.
5486:
Giovagnoli AR, Di Fede G, Aresi A, Reati F, Rossi G, Tagliavini F (December 2008). "Atypical frontotemporal dementia as a new clinical phenotype of
Gerstmann-Straussler-Scheinker disease with the PrP-P102L mutation. Description of a previously unreported Italian family".
2380:
have been linked with cognitive impairment in the elderly as well as earlier cognitive decline. All of these studies investigated differences in codon 129, indicating its importance in the overall functionality of PrP, in particular with regard to memory.
3077:
Robakis NK, Devine-Gage EA, Jenkins EC, Kascsak RJ, Brown WT, Krawczun MS, Silverman WP (October 1986). "Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain".
2458:
Though present, very low levels of PrP exist in the liver and could be associated with liver fibrosis. Presence in the pituitary has been shown to affect neuroendocrine function in amphibians, but little is known concerning mammalian pituitary PrP.
2263:. Based on the progressive nature of spongiform encephalopathies, the predominant hypothesis posits that the change from normal PrP is caused by the presence and interaction with PrP. Strong support for this is taken from studies in which
2454:
PrP-null mice provide clues to a role in muscular physiology when subjected to a forced swimming test, which showed reduced locomotor activity. Aging mice with an overexpression of PRNP showed significant degradation of muscle tissue.
2471:
has led to speculation on involvement in development. A wide range of studies has been conducted investigating the role in cell proliferation, differentiation, death, and survival. Engagement of PrP has been linked to activation of
2352:, a predominantly hippocampal-function, is decreased in the null mice and can be recovered with the reinstatement of PrP in neurons; this indicates that loss of PrP function is the cause. The interaction of hippocampal PrP with
2363:
Further support for PrP's role in memory formation is derived from several population studies. A test of healthy young humans showed increased long-term memory ability associated with an MM or MV genotype when compared to VV.
2421:
Though most attention is focused on PrP's presence in the nervous system, it is also abundant in immune system tissue. PrP immune cells include hematopoietic stem cells, mature lymphoid and myeloid compartments, and certain
5439:
He J, Li X, Yang J, Huang J, Fu X, Zhang Y, Fan H (March 2013). "The association between the methionine/valine (M/V) polymorphism (rs1799990) in the PRNP gene and the risk of
Alzheimer disease: an update by meta-analysis".
4524:
Del Bo R, Comi GP, Giorda R, Crimi M, Locatelli F, Martinelli-Boneschi F, et al. (June 2003). "The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects".
2770:. The decreased risk in V allele carriers is further limited to late-onset Alzheimer's disease only (≥ 65 years). PRNP can also functionally interact with polymorphisms in two other genes implicated in Alzheimer's,
2480:
along the protein bind other proteins, biomolecules, and metals. These interfaces allow specific sets of cells to communicate based on level of expression and the surrounding microenvironment. The anchoring on a
2015:
PrP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9 to 99.6% similarity in
2618:– TSE in humans, transmitted via funerary cannibalism. Generally, affected family members were given, by tradition, parts of the central nervous system according to ritual when consuming deceased family members.
711:
610:
5073:
Collins S, McLean CA, Masters CL (September 2001). "Gerstmann-Sträussler-Scheinker syndrome,fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies".
4294:
Criado JR, Sánchez-Alavez M, Conti B, Giacchino JL, Wills DN, Henriksen SJ, et al. (2005). "Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons".
4167:
Roesler R, Walz R, Quevedo J, de-Paris F, Zanata SM, Graner E, et al. (August 1999). "Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C)".
4611:
Croes EA, Dermaut B, Houwing-Duistermaat JJ, Van den Broeck M, Cruts M, Breteler MM, et al. (August 2003). "Early cognitive decline is associated with prion protein codon 129 polymorphism".
2267:-knockout mice are resistant to the introduction of PrP. Despite widespread acceptance of the conformation conversion hypothesis, some studies mitigate claims for a direct link between PrP and
4251:
Cagampang FR, Whatley SA, Mitchell AL, Powell JF, Campbell IC, Coen CW (1999). "Circadian regulation of prion protein messenger RNA in the rat forebrain: a widespread and synchronous rhythm".
4748:
Kardos J, Kovács I, Hajós F, Kálmán M, Simonyi M (August 1989). "Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability".
4654:
Kachiwala SJ, Harris SE, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ (September 2005). "Genetic influences on oxidative stress and their association with normal cognitive ageing".
4568:
Berr C, Richard F, Dufouil C, Amant C, Alperovitch A, Amouyel P (September 1998). "Polymorphism of the prion protein is associated with cognitive impairment in the elderly: the EVA study".
2147:
are confirmed PrP ligands that bind to its octarepeat region. Ligand binding causes a conformational change with unknown effect. Heavy metal binding at PrP has been linked to resistance to
1977:(vCJD). Similarities exist between kuru, thought to be due to human ingestion of diseased individuals, and vCJD, thought to be due to human ingestion of BSE-tainted cattle products.
3335:
Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, et al. (June 2005). "Anchorless prion protein results in infectious amyloid disease without clinical scrapie".
2328:
at codon 178, which corroborates PrP's involvement in sleep-wake cycles. In addition, circadian regulation has been demonstrated in PrP mRNA, which cycles regularly with day-night.
4124:
Nico PB, de-Paris F, Vinadé ER, Amaral OB, Rockenbach I, Soares BL, et al. (July 2005). "Altered behavioural response to acute stress in mice lacking cellular prion protein".
4397:
Coitinho AS, Freitas AR, Lopes MH, Hajj GN, Roesler R, Walz R, et al. (December 2006). "The interaction between prion protein and laminin modulates memory consolidation".
3734:
Kraus A, Hoyt F, Schwartz CL, Hansen B, Artikis E, Hughson AG, et al. (November 2021). "High-resolution structure and strain comparison of infectious mammalian prions".
2612:(mad-cow disease) – fatal neurodegenerative disease in cows, which can be transmitted to humans by ingestion of brain, spinal, or digestive tract tissue of an infected cow
6129:
6114:
6099:
7106:
5994:
2051:, and this proves to be integral to the transmission of conformational change; secreted PrP lacking the anchor component is unaffected by the infectious isoform.
4081:
Katamine S, Nishida N, Sugimoto T, Noda T, Sakaguchi S, Shigematsu K, et al. (December 1998). "Impaired motor coordination in mice lacking prion protein".
3883:
Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J (February 2011). "Prion propagation and toxicity in vivo occur in two distinct mechanistic phases".
2129:-protein, but, so far, no such compound has been identified. However, a large body of research has developed on candidates and their interaction with the PrP.
5754:
6245:
2588:
gene (called polymorphisms) do not cause prion diseases but may affect a person's risk of developing these diseases or alter the course of the disorders. An
2294:
The strong association to neurodegenerative diseases raises many questions of the function of PrP in the brain. A common approach is using PrP-knockout and
3034:
Liao YC, Lebo RV, Clawson GA, Smuckler EA (July 1986). "Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications".
2819:
pharmaceuticals can be made in their blood without the danger that those products might get contaminated with the infectious agent that causes mad cow.
1529:
1510:
533:
2795:
2536:
1966:
5030:
Kovács GG, Trabattoni G, Hainfellner JA, Ironside JW, Knight RS, Budka H (November 2002). "Mutations of the prion protein gene phenotypic spectrum".
2940:
Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ (August 1986). "Molecular cloning of a human prion protein cDNA".
6159:
6144:
7096:
6223:
2922:
2904:
2167:
copper into cells from the surrounding environment. Researchers have also proposed roles for PrP in cell signaling or in the formation of
72:
2310:
results in decreased motor coordination. However, this effect is not a direct result of PrP's absence, and rather arises from increased
7076:
1804:
7938:
6262:
6238:
1797:
2413:
outgrowth. The PrP-activated signal transduction pathway is associated with axon and dendritic outgrowth with a series of kinases.
1915:
7669:
2501:
2443:
5919:
3586:"Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro"
7657:
7435:
2402:(LTP). This effect can be positive or negative and is due to changes in neuronal excitability and synaptic transmission in the
5934:
8270:
7721:
7716:
7662:
7442:
5734:
2675:-knockout mice were found to be indistinguishable from control with respect to both neuronal death rates and measurements of
2314:
gene expression. Other observed differences include reduced stress response and increased exploration of novel environments.
1974:
2887:
34:, infectious forms of proteins which have so far been observed in almost all instances to be forms of PRNP, but need not be.
8275:
7175:
7101:
6231:
4793:"The persistence of long-term memory: a molecular approach to self-sustaining changes in learning-induced synaptic growth"
8204:
8199:
8194:
8189:
7116:
2866:
2719:
deletion has been prophylactically implemented by the cattle industry without apparent harm. In mice, this same deletion
5531:
3456:
Linden R, Martins VR, Prado MA, Cammarota M, Izquierdo I, Brentani RR (April 2008). "Physiology of the prion protein".
3300:
Schätzl HM, Da Costa M, Taylor L, Cohen FE, Prusiner SB (January 1995). "Prion protein gene variation among primates".
2442:
activation is accompanied by a strong up-regulation of PrP, though it is not requisite. The lack of immunoresponse to
8169:
6189:
5949:
1942:
2398:
mechanism, a calcium modulator, or a sensor for copper or oxidative stress. Loss of PrP function has been linked to
697:
7405:
5784:
5769:
2609:
1938:
1934:
6174:
6084:
5814:
5799:
2727:
activity, contributing to conflicting results when examining
Alzheimer's survival rates. Of note, the deletion of
7973:
7467:
7153:
6069:
6054:
2891:
2870:
2762:
carriers (VV and MV) show a 13% decreased risk with respect to developing
Alzheimer's compared to the methionine
2059:
674:
2074:- terminal ends are removed posttranslationally, resulting in a mature length of 208 amino acids. For human and
7612:
7148:
5904:
5889:
5874:
5859:
5844:
5829:
4995:
Castilla J, Hetz C, Soto C (June 2004). "Molecular mechanisms of neurotoxicity of pathological prion protein".
1946:
1574:
6253:
6204:
8109:
7581:
7576:
7521:
7255:
6704:
2779:
2518:
1958:
596:
571:
1555:
7803:
7526:
5979:
5964:
3677:
2176:
513:
2715:
when injected with Aβ oligomers. In mammals, the full functional significance of PRNP remains unclear, as
7121:
2828:
2025:
5605:
Americo TA, Chiarini LB, Linden R (June 2007). "Signaling induced by hop/STI-1 depends on endocytosis".
3828:"Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains"
3496:"Prion protein prevents heavy metals overloading of cells and thus protects them against their toxicity"
7833:
6258:
6009:
2220:
2114:
1876:
710:
609:
5642:"Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection"
5196:"Brain disease 'resistance gene' evolves in Papua New Guinea community; could offer insights into CJD"
6699:
5727:
5556:
Richt JA, Kasinathan P, Hamir AN, Castilla J, Sathiyaseelan T, Vargas F, et al. (January 2007).
5117:
Montagna P, Gambetti P, Cortelli P, Lugaresi E (March 2003). "Familial and sporadic fatal insomnia".
3398:"Pseudoknots in prion protein mRNAs confirmed by comparative sequence analysis and pattern searching"
2667:
or a site-specific relational significance. In the case of direct injection of Aβ oligomers into the
2481:
2044:
1751:
1747:
1743:
703:
602:
2259:
The propagation of PrP is a topic of great interest, as its accumulation is a pathological cause of
500:
7883:
6778:
5707:
5701:
3357:
2723:
varies between
Alzheimer's mouse lines, as hAPPJ20 mice and TgCRND8 mice show a slight increase in
1776:
1725:
1721:
1717:
1713:
1685:
1664:
1654:
1650:
1646:
521:
4340:"Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein"
2125:
The mechanism for conformational conversion to the scrapie isoform is speculated to be an elusive
1755:
1739:
504:, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
7847:
6039:
6024:
5697:
5195:
4204:"Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene"
2791:
2553:
2321:
2215:
nitrogens from the 2nd and 3rd glycines in the repeat. The ability to bind copper is, therefore,
1962:
1950:
4202:
Medori R, Tritschler HJ, LeBlanc A, Villare F, Manetto V, Chen HY, et al. (February 1992).
1780:
1735:
1709:
1689:
1642:
1638:
7190:
7185:
7180:
7170:
6477:
6405:
3352:
2807:
2632:
2399:
2373:
2274:
4338:
Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, et al. (February 2010).
2663:
deficits. This would suggest either an unequal relation between PRNP and Aβ oligomer-mediated
2651:
in animals has yielded several conflicting findings. When Aβ oligomers were injected into the
6534:
6452:
5640:
Zanata SM, Lopes MH, Mercadante AF, Hajj GN, Chiarini LB, Nomizo R, et al. (July 2002).
5381:"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers"
4891:"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers"
4440:
Shorter J, Lindquist S (June 2005). "Prions as adaptive conduits of memory and inheritance".
2239:
PrP is a conformational isoform of PrP, but this orientation tends to accumulate in compact,
2000:
585:
6138:: Ovine recombinant PrP(114-234), ARR variant in complex with the VRQ14 Fab fragment (IgG2a)
4483:
Papassotiropoulos A, Wollmer MA, Aguzzi A, Hock C, Nitsch RM, de
Quervain DJ (August 2005).
8280:
7771:
7484:
6123:: Ovine recombinant PrP(114-234), VRQ variant in complex with the Fab of the VRQ14 antibody
6108:: Ovine recombinant PrP(114-234), ARQ variant in complex with the Fab of the VRQ14 antibody
5720:
5392:
5160:
Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, et al. (November 2009).
4902:
4351:
3991:
3892:
3839:
3782:
3692:
3344:
3254:
3043:
2988:
2766:(MM). However, the protective effects of variant V carriers have been found exclusively in
2747:
2680:
2659:
deletion did not offer protection, only anti-PrP antibodies prevented long-term memory and
2489:
2446:(TSE), neurodegenerative diseases caused by prions, could stem from the tolerance for PrP.
2427:
2152:
17:
5281:
Laurén J (2014). "Cellular prion protein as a therapeutic target in
Alzheimer's disease".
541:
8:
7798:
7617:
3934:
BĂĽeler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, Weissmann C (July 1993).
2676:
2473:
2244:
1985:
5396:
4906:
4355:
3896:
3843:
3786:
3696:
3678:"NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231)"
3348:
3258:
3047:
2992:
2975:
Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, et al. (October 1986).
7205:
6939:
5582:
5557:
5512:
5465:
5413:
5380:
5351:
5326:
5241:
5216:
5142:
5099:
5055:
4972:
4947:
4923:
4890:
4871:
4822:
4773:
4725:
4715:
4698:
4679:
4636:
4593:
4550:
4465:
4422:
4374:
4339:
4320:
4276:
4228:
4203:
4149:
4106:
3916:
3860:
3827:
3803:
3770:
3716:
3658:
3615:
3566:
3378:
3277:
3242:
3179:
2652:
2248:
1919:
545:
6003:: Crystal structure of the human prion protein reveals a mechanism for oligomerization
5666:
5641:
5130:
4264:
4180:
3704:
3633:
Ross CA, Poirier MA (July 2004). "Protein aggregation and neurodegenerative disease".
3011:
2976:
2409:
Some research indicates PrP involvement in neuronal development, differentiation, and
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
5671:
5622:
5587:
5504:
5457:
5418:
5356:
5298:
5246:
5183:
5134:
5091:
5047:
5012:
4977:
4963:
4928:
4863:
4858:
4841:
4814:
4765:
4761:
4730:
4697:
Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, et al. (October 1999).
4671:
4628:
4585:
4542:
4506:
4457:
4414:
4410:
4379:
4312:
4268:
4233:
4184:
4141:
4098:
4063:
4022:
3995:
3957:
3952:
3935:
3908:
3865:
3826:
Hoyt F, Standke HG, Artikis E, Schwartz CL, Hansen B, Li K, et al. (July 2022).
3808:
3769:
Manka SW, Zhang W, Wenborn A, Betts J, Joiner S, Saibil HR, et al. (July 2022).
3751:
3708:
3662:
3650:
3607:
3602:
3585:
3558:
3553:
3536:
3517:
3473:
3427:
3422:
3397:
3370:
3317:
3282:
3223:
3171:
3136:
3095:
3091:
3059:
3016:
2957:
2664:
2337:
2260:
2243:-resistant aggregates within neural tissue. The abnormal PrP isoform has a different
2224:
2163:
The precise function of PrP is not yet known. It may play a role in the transport of
1923:
493:
65:
5516:
5469:
5146:
5103:
5059:
4875:
4777:
4683:
4640:
4597:
4554:
4426:
4280:
4153:
4110:
3720:
3619:
3570:
3382:
3183:
2639:
are composed of smaller Aβ plaques, and are the most damaging to the integrity of a
7978:
7711:
7632:
7195:
6388:
6314:
5661:
5653:
5614:
5577:
5569:
5496:
5449:
5408:
5400:
5346:
5338:
5290:
5236:
5228:
5173:
5126:
5083:
5039:
5004:
4967:
4959:
4918:
4910:
4853:
4826:
4804:
4757:
4720:
4710:
4663:
4620:
4577:
4534:
4496:
4469:
4449:
4406:
4369:
4359:
4324:
4304:
4260:
4223:
4215:
4176:
4133:
4090:
4053:
3987:
3947:
3920:
3900:
3855:
3847:
3798:
3790:
3743:
3700:
3642:
3597:
3548:
3507:
3465:
3417:
3409:
3362:
3309:
3272:
3262:
3213:
3163:
3126:
3087:
3051:
3006:
2996:
2949:
2775:
2696:
2660:
2349:
2341:
2317:
2196:
repeats with sequence PHGGGWGQ (though the first repeat has the slightly modified,
2148:
2110:
2017:
790:
721:
665:
620:
5763:: PRION PROTEIN DOMAIN PRP(121-231) FROM MOUSE, NMR, 2 MINIMIZED AVERAGE STRUCTURE
5692:
2599:
In addition, some prion diseases can be transmitted from external sources of PrP.
525:
8038:
6574:
6569:
6492:
4809:
4792:
4667:
3747:
3200:
Zomosa-Signoret V, Arnaud JD, Fontes P, Alvarez-Martinez MT, Liautard JP (2008).
2977:"Assignment of the human and mouse prion protein genes to homologous chromosomes"
2712:
2071:
2040:
765:
549:
4219:
3131:
3114:
2927:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2909:
National Center for
Biotechnology Information, U.S. National Library of Medicine
7823:
7245:
6756:
6559:
5618:
4344:
Proceedings of the National Academy of Sciences of the United States of America
3851:
3794:
3469:
3247:
Proceedings of the National Academy of Sciences of the United States of America
2981:
Proceedings of the National Academy of Sciences of the United States of America
2783:
2767:
2720:
2692:
2615:
2593:
2391:
2303:
2277:
at sites 136, 154, and 171 are associated with varying susceptibility to ovine
2201:
2075:
2063:
1970:
1884:
866:
5500:
5453:
5379:
Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (February 2009).
5342:
5215:
Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, et al. (2009).
5162:"A novel protective prion protein variant that colocalizes with kuru exposure"
5043:
4889:
Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (February 2009).
4538:
4308:
4137:
4094:
3978:
Aguzzi A, Baumann F, Bremer J (2008). "The prion's elusive reason for being".
8264:
7793:
7250:
6341:
5008:
4610:
3218:
3201:
2835:
2684:
2644:
2557:
2522:
2511:
2485:
2365:
2189:
2172:
2102:
2098:
179 of the second helix and Cys214 of the third helix (human PrP numbering).
2079:
2048:
1989:
984:
955:
948:
4364:
3584:
Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G (December 2005).
3366:
3267:
3241:
Damberger FF, Christen B, PĂ©rez DR, Hornemann S, WĂĽthrich K (October 2011).
3055:
3001:
926:
804:
8149:
7457:
7447:
6978:
6944:
5675:
5657:
5626:
5591:
5508:
5461:
5422:
5360:
5302:
5250:
5187:
5138:
5095:
5087:
5051:
5016:
4981:
4932:
4867:
4818:
4734:
4675:
4632:
4546:
4510:
4461:
4418:
4383:
4316:
4272:
4188:
4145:
4067:
4026:
3999:
3912:
3869:
3812:
3755:
3654:
3611:
3562:
3521:
3512:
3495:
3477:
3431:
3413:
3374:
3313:
3286:
3227:
3199:
3175:
3140:
2953:
2758:(rs1799990) is most closely associated with Alzheimer's disease. Variant V
2628:
2268:
2032:
1911:
783:
562:
5178:
5161:
4769:
4589:
4237:
4102:
4058:
4041:
3961:
3712:
3321:
3099:
3063:
3020:
2961:
1844:
1839:
8159:
7808:
7586:
7561:
7260:
6882:
6808:
6282:
4581:
4501:
4484:
2832:
2708:
2700:
2668:
2423:
2403:
2395:
2253:
2021:
1619:
1600:
5404:
5232:
4914:
3904:
3537:"Antioxidant activity related to copper binding of native prion protein"
3167:
8089:
7813:
7494:
7235:
7111:
6744:
6739:
6734:
6589:
6373:
5294:
3676:
Riek R, Hornemann S, Wider G, Glockshuber R, WĂĽthrich K (August 1997).
2763:
2740:
2732:
2606:– fatal neurodegenerative disease in sheep, not transmissible to humans
2578:
2565:
2561:
2468:
2307:
2295:
2228:
2208:
2180:
2106:
2083:
2055:
2028:
2020:. The human protein structure consists of a globular domain with three
1410:
regulation of intracellular calcium activated chloride channel activity
682:
579:
529:
6168:: Solution structure of the sheep prion protein with polymorphism H168
4624:
2939:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
7928:
7923:
7918:
7908:
7903:
7898:
7893:
6153:: THE CRYSTAL STRUCTURE OF THE GLOBULAR DOMAIN OF SHEEP PRION PROTEIN
2724:
2435:
2431:
2205:
2200:-deficient sequence PQGGGGWGQ). This is thought to generate a copper-
2197:
2140:
2091:
2004:
1474:
749:
736:
648:
635:
537:
5573:
4699:"Evidence of presynaptic location and function of the prion protein"
4453:
2802:
in cases of ambiguously diagnosed dementia, as the various forms of
2372:
substitution have been linked to earlier cognitive decline. Several
2356:(LN) is pivotal in memory processing and is likely modulated by the
8234:
8134:
7948:
7933:
7136:
7131:
7039:
6729:
5029:
3646:
2803:
2636:
2240:
2095:
1899:
1891:
1828:
5708:
Susan Lindquist's Seminar: "The Surprising World of Prion Biology"
4482:
4293:
2846:
organizing protein; also called STI1 (Stress-induced protein 1)).
2790:
at least in part contributed to three separate patients' atypical
2643:. The precise mechanism of soluble Aβ oligomers directly inducing
1420:
negative regulation of amyloid precursor protein catabolic process
8184:
8179:
8174:
8074:
7888:
7878:
7705:
7684:
7679:
7647:
7452:
7372:
7367:
7362:
7357:
7352:
7270:
6963:
6803:
6798:
6793:
6788:
6783:
6254:
2603:
2573:
progression of neurodegeneration and is the proposed cause. Some
2548:
2544:
2410:
2357:
2353:
2278:
2193:
2168:
2087:
1930:
1880:
1586:
1541:
1459:
1455:
5116:
3583:
3076:
1260:
negative regulation of DNA-binding transcription factor activity
517:
8124:
8084:
8069:
8053:
8048:
8028:
8023:
7958:
7766:
7736:
7700:
7691:
7504:
7472:
7336:
7331:
7301:
7280:
7240:
7200:
7066:
7044:
7003:
6927:
6922:
6917:
6912:
6907:
6902:
6771:
6766:
6761:
6709:
6694:
6564:
6554:
6517:
6512:
6430:
6425:
3882:
3240:
2759:
2744:
2640:
2589:
2530:
2526:
2439:
2369:
2345:
2183:
2144:
2132:
2126:
1812:
1496:
964:
5712:
4250:
4201:
3334:
1425:
positive regulation of protein localization to plasma membrane
8249:
8224:
8144:
8139:
8129:
8119:
8104:
8099:
8094:
8079:
8033:
8018:
7983:
7968:
7963:
7953:
7873:
7868:
7863:
7842:
7838:
7828:
7741:
7642:
7637:
7596:
7546:
7541:
7536:
7531:
7516:
7509:
7489:
7477:
7420:
7415:
7410:
7400:
7395:
7388:
7326:
7316:
7311:
7306:
7296:
7275:
7265:
7230:
7225:
7220:
7215:
7210:
7165:
7160:
7126:
7091:
7086:
7081:
7071:
7059:
7054:
7034:
7029:
7024:
7019:
6973:
6865:
6860:
6679:
6663:
6656:
6651:
6646:
6641:
6636:
6631:
6606:
6584:
6579:
6472:
6398:
6393:
6383:
4948:"The role of the cellular prion protein in the immune system"
4842:"Common molecular mechanisms in explicit and implicit memory"
4337:
3675:
2843:
2839:
2771:
2751:
2592:
that codes for a PRNP variant, G127V, provides resistance to
2540:
2212:
2067:
1927:
1350:
calcium-mediated signaling using intracellular calcium source
31:
5555:
4653:
2707:
codes for the enzyme Fyn, FYN-knockout mice display neither
2679:. It was further found that Aβ-oligomers bind to PrP at the
2631:(Aβ) oligomers, which are canonically implicated in causing
2627:
PrP protein is one of several cellular receptors of soluble
2003:
between the end (terminus) of the arm and position 13, from
8244:
8239:
8229:
8219:
8214:
8209:
8164:
8154:
8114:
8043:
8013:
8008:
8003:
7998:
7993:
7988:
7943:
7913:
7818:
7786:
7781:
7761:
7751:
7746:
7731:
7726:
7627:
7622:
7591:
7571:
7566:
7556:
7551:
7430:
7383:
7343:
6998:
6993:
6988:
6983:
6968:
6959:
6954:
6949:
6934:
6892:
6887:
6877:
6872:
6855:
6850:
6845:
6840:
6835:
6830:
6825:
6820:
6815:
6751:
6724:
6719:
6714:
6689:
6684:
6621:
6616:
6611:
6601:
6596:
6549:
6544:
6539:
6529:
6524:
6507:
6502:
6497:
6487:
6482:
6467:
6462:
6457:
6447:
6442:
6437:
6420:
6415:
6410:
6361:
6329:
6324:
6319:
6302:
6297:
6292:
6287:
5485:
4080:
3455:
3396:
Barrette I, Poisson G, Gendron P, Major F (February 2001).
3395:
2394:. In this role, the protein could serve as either a copper
2348:, this is attributable to Doppel gene expression. However,
2311:
2136:
1954:
1868:
48:
5378:
4888:
4485:"The prion gene is associated with human long-term memory"
4166:
3825:
3299:
2047:(GPI) membrane anchor at the COOH-terminal tethers PrP to
7756:
6368:
6356:
6351:
6346:
6336:
6309:
6277:
5639:
4042:"PrP knock-out and PrP transgenic mice in prion research"
3933:
3489:
3487:
3115:"Shattuck lecture--neurodegenerative diseases and prions"
2704:
2703:, another protein implicated in Alzheimer's. As the gene
2688:
2164:
1240:
negative regulation of calcineurin-NFAT signaling cascade
5159:
4396:
4123:
2974:
2699:, forming a complex with Fyn and excessively activating
2113:), which is thought to be involved in regulation of PrP
1370:
positive regulation of peptidyl-tyrosine phosphorylation
1265:
negative regulation of T cell receptor signaling pathway
773:
4747:
4567:
3733:
3154:
Weissmann C (November 2004). "The state of the prion".
3033:
2794:
within the same family, suggesting a new phenotype for
2344:
consolidation deficits have been demonstrated. As with
2216:
1440:
regulation of calcium ion import across plasma membrane
1375:
positive regulation of protein tyrosine kinase activity
3771:"2.7 Ă… cryo-EM structure of ex vivo RML prion fibrils"
3768:
3484:
1887:
but occurs in many other tissues throughout the body.
1390:
negative regulation of long-term synaptic potentiation
1194:
anchored component of external side of plasma membrane
5604:
5214:
4696:
4523:
3493:
1275:
negative regulation of activated T cell proliferation
938:
5928:: HUMAN PRION PROTEIN (MUTANT E200K) FRAGMENT 90-231
5072:
4945:
4013:
Atkinson M (October 2001). "National scrapie plan".
2495:
2336:
While null mice exhibit normal learning ability and
2090:
PrP has glycosylation sites as Asn180 and Asn196. A
1380:
positive regulation of protein targeting to membrane
5607:
Biochemical and Biophysical Research Communications
3977:
3080:
Biochemical and Biophysical Research Communications
2510:gene have been identified in people with inherited
2324:is thought to be the result of a point mutation in
1320:
regulation of potassium ion transmembrane transport
5943:: HUMAN PRION PROTEIN MUTANT E200K FRAGMENT 90-231
5481:
5479:
4946:Isaacs JD, Jackson GS, Altmann DM (October 2006).
3243:"Cellular prion protein conformation and function"
3202:"Physiological role of the cellular prion protein"
2883:
2881:
2879:
2862:
2860:
2858:
1415:negative regulation of dendritic spine maintenance
1395:regulation of glutamate receptor signaling pathway
1230:negative regulation of interferon-gamma production
4839:
4039:
3534:
2158:
720:
619:
8262:
4994:
4439:
2449:
1305:negative regulation of interleukin-17 production
5476:
2876:
2855:
2695:. Soluble Aβ oligomers also bind to PrP at the
1365:regulation of peptidyl-tyrosine phosphorylation
1360:positive regulation of neuron apoptotic process
1315:negative regulation of interleukin-2 production
5374:
5372:
5370:
5276:
5274:
5272:
5270:
5268:
5266:
5264:
5262:
5260:
4790:
3535:Brown DR, Clive C, Haswell SJ (January 2001).
2888:GRCm38: Ensembl release 89: ENSMUSG00000079037
2390:function casts PrP as a copper buffer for the
1225:negative regulation of protein phosphorylation
1068:type 8 metabotropic glutamate receptor binding
1063:type 5 metabotropic glutamate receptor binding
6239:
5728:
5438:
4791:Bailey CH, Kandel ER, Si K (September 2004).
3936:"Mice devoid of PrP are resistant to scrapie"
3494:Prčina M, Kontseková E, Novák M (June 2015).
1405:negative regulation of amyloid-beta formation
5633:
5598:
5558:"Production of cattle lacking prion protein"
5320:
5318:
5316:
5314:
5312:
5208:
5110:
5066:
5023:
4988:
4939:
4882:
4833:
4784:
4690:
4647:
4604:
4517:
4476:
4433:
4390:
4331:
4287:
4244:
4160:
4117:
4033:
3876:
3626:
3528:
3328:
3234:
3147:
2778:, to compound risk for both Alzheimer's and
1918:version PrP is associated with a variety of
5367:
5257:
4840:Barco A, Bailey CH, Kandel ER (June 2006).
4741:
4561:
4195:
4074:
3927:
3632:
3293:
3106:
2867:GRCh38: Ensembl release 89: ENSG00000171867
2171:. PrP attaches to the outer surface of the
27:Protein involved in multiple prion diseases
6246:
6232:
5735:
5721:
5532:"Scientists Announce Mad Cow Breakthrough"
5434:
5432:
3973:
3971:
3451:
3449:
3447:
3445:
3443:
3441:
3195:
3193:
3070:
3027:
2968:
2933:
2234:
6263:list of human clusters of differentiation
6198:: Mouse Prion Protein with mutation N174T
5958:: HUMAN PRION PROTEIN 121-230 M166C/E221C
5700:at the U.S. National Library of Medicine
5665:
5581:
5412:
5350:
5309:
5240:
5177:
4971:
4922:
4857:
4808:
4724:
4714:
4500:
4373:
4363:
4227:
4057:
3951:
3859:
3802:
3601:
3552:
3511:
3421:
3356:
3276:
3266:
3217:
3153:
3130:
3010:
3000:
2647:is unknown, and experimental deletion of
2444:transmissible spongiform encephalopathies
1355:negative regulation of catalytic activity
1335:negative regulation of protein processing
5331:Intractable & Rare Diseases Research
4169:Brain Research. Molecular Brain Research
4012:
3112:
1999:gene is located on the short (p) arm of
1984:
1250:negative regulation of apoptotic process
1204:intracellular membrane-bounded organelle
5793:: BOVINE PRION PROTEIN FRAGMENT 121-230
5778:: BOVINE PRION PROTEIN FRAGMENT 121-230
5429:
5327:"Alzheimer's disease and prion protein"
5324:
3968:
3438:
3190:
2796:Gerstmann–Sträussler–Scheinker syndrome
2537:Gerstmann–Sträussler–Scheinker syndrome
2502:Transmissible spongiform encephalopathy
2384:
2302:As the null mice age, a marked loss of
1967:Gerstmann–Sträussler–Scheinker syndrome
14:
8263:
6183:: mouse prion protein fragment 121-231
6093:: HUMAN PRION PROTEIN FRAGMENT 121-230
5823:: BOVINE PRION PROTEIN RESIDUES 23-230
5808:: BOVINE PRION PROTEIN RESIDUES 23-230
5280:
3992:10.1146/annurev.neuro.31.060407.125620
2731:in both APPswe and SEN1dE9, two other
2622:
2467:Varying expression of PrP through the
1864:) is encoded in the human body by the
6227:
6078:: HUMAN PRION PROTEIN FRAGMENT 90-230
6063:: HUMAN PRION PROTEIN FRAGMENT 90-230
5716:
5529:
5217:"A systems approach to prion disease"
2798:. The same study proposed sequencing
2577:mutations lead to a change in single
1345:activation of protein kinase activity
725:
686:
681:
624:
583:
578:
5442:Journal of the Neurological Sciences
4952:Clinical and Experimental Immunology
4399:The European Journal of Neuroscience
2204:via nitrogen atoms in the histidine
1910:(scrapie) and an isoform located in
5913:: HUMAN PRION PROTEIN VARIANT R220K
5898:: HUMAN PRION PROTEIN VARIANT R220K
5883:: HUMAN PRION PROTEIN VARIANT S170N
5868:: HUMAN PRION PROTEIN VARIANT S170N
5853:: HUMAN PRION PROTEIN VARIANT M166V
5838:: HUMAN PRION PROTEIN VARIANT M166V
5202:(Press release). November 21, 2009.
5166:The New England Journal of Medicine
4208:The New England Journal of Medicine
4083:Cellular and Molecular Neurobiology
3119:The New England Journal of Medicine
2054:The primary sequence of PrP is 253
1400:positive regulation of neuron death
24:
6213:: Ovine Prion Protein Variant R168
4716:10.1523/JNEUROSCI.19-20-08866.1999
2780:sporadic Creutzfeldt–Jakob disease
2223:shows copper binding results in a
2082:sites exist on helices 2 and 3 at
2007:4,615,068 to base pair 4,630,233.
1890:The protein can exist in multiple
1270:regulation of protein localization
1078:protein-containing complex binding
25:
8292:
5685:
2655:of a mouse model of Alzheimer's,
2496:Diseases caused by PrP misfolding
2289:
2120:
1975:variant Creutzfeldt–Jakob disease
1943:transmissible mink encephalopathy
1435:cellular response to amyloid-beta
1330:positive regulation of cell death
1003:transmembrane transporter binding
6203:
6188:
6173:
6158:
6143:
6128:
6113:
6098:
6083:
6068:
6053:
6038:
6023:
6008:
5993:
5978:
5963:
5948:
5933:
5918:
5903:
5888:
5873:
5858:
5843:
5828:
5813:
5798:
5783:
5768:
5753:
5076:Journal of Clinical Neuroscience
4964:10.1111/j.1365-2249.2006.03194.x
4859:10.1111/j.1471-4159.2006.03870.x
4411:10.1111/j.1460-9568.2006.05156.x
4040:Weissmann C, Flechsig E (2003).
3603:10.1111/j.1471-4159.2005.03469.x
3554:10.1046/j.1471-4159.2001.00009.x
2683:, indirectly overactivating the
2610:Bovine spongiform encephalopathy
2426:; also, it has been detected in
2416:
1939:feline spongiform encephalopathy
1935:bovine spongiform encephalopathy
954:
947:
709:
702:
696:
673:
608:
601:
595:
570:
47:
5988:: HUMAN PRION PROTEIN AT PH 7.0
5973:: HUMAN PRION PROTEIN AT PH 7.0
5742:
5549:
5523:
5153:
4006:
3819:
3762:
3727:
3669:
3577:
3389:
2822:
2514:, which include the following:
2060:post-translational modification
1290:cellular response to copper ion
1285:cellular copper ion homeostasis
1169:extrinsic component of membrane
5283:Journal of Alzheimer's Disease
2915:
2897:
2506:More than 20 mutations in the
1947:exotic ungulate encephalopathy
1154:anchored component of membrane
1119:integral component of membrane
965:More reference expression data
927:More reference expression data
893:Region I of hippocampus proper
819:Region I of hippocampus proper
13:
1:
5131:10.1016/S1474-4422(03)00323-5
4265:10.1016/S0306-4522(99)00092-5
4181:10.1016/S0169-328X(99)00193-X
3980:Annual Review of Neuroscience
3705:10.1016/S0014-5793(97)00920-4
2849:
2584:Several other changes in the
2450:Muscles, liver, and pituitary
2159:PrP (normal cellular) isoform
1926:diseases such as in animals:
1445:neuron projection maintenance
1013:ATP-dependent protein binding
694:
593:
8271:Genes on human chromosome 20
4810:10.1016/j.neuron.2004.09.017
4762:10.1016/0304-3940(89)90565-X
4668:10.1016/j.neulet.2005.05.067
3953:10.1016/0092-8674(93)90360-3
3748:10.1016/j.molcel.2021.08.011
3302:Journal of Molecular Biology
3156:Nature Reviews. Microbiology
3092:10.1016/0006-291X(86)90796-5
2568:is present at amino acid 129
2533:is present at amino acid 129
2177:glycosylphosphatidylinositol
2010:
1906:such as the disease-causing
1255:response to oxidative stress
1104:mitochondrial outer membrane
847:Epithelium of choroid plexus
7:
8276:Clusters of differentiation
6259:clusters of differentiation
6018:: HUMAN PRION PROTEIN 61-84
4703:The Journal of Neuroscience
4220:10.1056/NEJM199202133260704
3132:10.1056/NEJM200105173442006
2831:exists between PrP and the
2813:
2462:
2284:
1902:-resistant form designated
1883:is most predominant in the
1385:dendritic spine maintenance
1310:protein homooligomerization
1073:signaling receptor activity
877:nucleus of stria terminalis
10:
8297:
5619:10.1016/j.bbrc.2007.04.202
5530:Weiss R (1 January 2007).
5325:Zhou J, Liu B (May 2013).
4997:Current Molecular Medicine
4126:Behavioural Brain Research
3852:10.1038/s41467-022-30458-6
3795:10.1038/s41467-022-30457-7
3470:10.1152/physrev.00007.2007
2499:
1877:cluster of differentiation
823:retinal pigment epithelium
29:
8062:
7856:
7605:
7289:
7012:
6672:
6270:
5748:
5501:10.1007/s10072-008-1025-z
5454:10.1016/j.jns.2013.01.020
5343:10.5582/irdr.2013.v2.2.35
5221:Molecular Systems Biology
5044:10.1007/s00415-002-0896-9
4846:Journal of Neurochemistry
4539:10.1007/s00415-003-1057-5
4309:10.1016/j.nbd.2005.01.001
4138:10.1016/j.bbr.2005.02.003
3590:Journal of Neurochemistry
3541:Journal of Neurochemistry
2923:"Mouse PubMed Reference:"
2905:"Human PubMed Reference:"
2806:can prove challenging to
2713:dendritic spine shrinkage
2519:Creutzfeldt–Jakob disease
2490:extracellular scaffolding
2331:
2320:is altered in null mice.
2045:glycophosphatidylinositol
1959:Creutzfeldt–Jakob disease
1843:
1838:
1834:
1827:
1811:
1805:Chr 2: 131.75 – 131.78 Mb
1792:
1773:
1769:
1732:
1708:
1701:
1682:
1678:
1661:
1637:
1630:
1617:
1613:
1598:
1594:
1585:
1572:
1568:
1553:
1549:
1540:
1527:
1523:
1508:
1504:
1495:
1480:
1473:
1469:
1453:
1058:glycosaminoglycan binding
1033:identical protein binding
983:
979:
962:
946:
937:
924:
873:
864:
811:
802:
772:
764:
760:
743:
730:
693:
672:
663:
659:
642:
629:
592:
569:
560:
556:
511:
508:
498:
491:
486:
91:
86:
69:
64:
59:
55:
46:
41:
5702:Medical Subject Headings
5009:10.2174/1566524043360654
4489:Human Molecular Genetics
4442:Nature Reviews. Genetics
4046:British Medical Bulletin
3113:Prusiner SB (May 2001).
1937:(BSE, mad cow disease),
1879:230). Expression of the
1430:response to amyloid-beta
913:anterior amygdaloid area
30:Not to be confused with
4365:10.1073/pnas.0911829107
4297:Neurobiology of Disease
4095:10.1023/A:1020234321879
3367:10.1126/science.1110837
3268:10.1073/pnas.1106325108
3056:10.1126/science.3014653
3002:10.1073/pnas.83.19.7358
2808:differentially diagnose
2792:frontotemporal dementia
2554:fatal familial insomnia
2368:patients with a single
2322:Fatal familial insomnia
2252:extremely resistant to
1980:
1963:fatal familial insomnia
1951:chronic wasting disease
1340:protein destabilization
1235:response to cadmium ion
5088:10.1054/jocn.2001.0919
3513:10.4149/av_2015_02_179
3402:Nucleic Acids Research
3314:10.1006/jmbi.1994.0030
3219:10.1051/vetres:2007048
2954:10.1089/dna.1986.5.315
2539:– usually a change in
2488:supports claims of an
2400:long-term potentiation
1992:
1245:response to copper ion
6048:: HUMAN PRION PROTEIN
6033:: HUMAN PRION PROTEIN
5489:Neurological Sciences
5179:10.1056/NEJMoa0809716
5119:The Lancet. Neurology
4015:The Veterinary Record
3832:Nature Communications
3775:Nature Communications
3458:Physiological Reviews
2691:enzyme, resulting in
2235:PrP (scrapie) isoform
1988:
1798:Chr 20: 4.69 – 4.7 Mb
1159:extracellular exosome
1144:endoplasmic reticulum
586:Chromosome 20 (human)
5658:10.1093/emboj/cdf325
5562:Nature Biotechnology
5032:Journal of Neurology
4750:Neuroscience Letters
4656:Neuroscience Letters
4582:10.1212/wnl.51.3.734
4527:Journal of Neurology
3742:(21): 4540–4551.e6.
3641:(7 Suppl): S10–S17.
3414:10.1093/nar/29.3.753
2681:postsynaptic density
2560:-178 is replaced by
2525:-200 is replaced by
2428:natural killer cells
2385:Neurons and synapses
2153:heavy metal toxicity
2094:bond exists between
2018:amino acid sequences
1953:(CWD) which affects
1179:postsynaptic density
1048:amyloid-beta binding
827:orbitofrontal cortex
727:2 F2|2 64.07 cM
688:Chromosome 2 (mouse)
87:List of PDB id codes
60:Available structures
5698:PRNP+protein,+human
5691:PRNP (PrP) gene at
5536:The Washington Post
5405:10.1038/nature07761
5397:2009Natur.457.1128L
5391:(7233): 1128–1132.
5233:10.1038/msb.2009.10
4915:10.1038/nature07761
4907:2009Natur.457.1128L
4901:(7233): 1128–1132.
4613:Annals of Neurology
4356:2010PNAS..107.2295B
4059:10.1093/bmb/66.1.43
3905:10.1038/nature09768
3897:2011Natur.470..540S
3844:2022NatCo..13.4005H
3787:2022NatCo..13.4004M
3697:1997FEBSL.413..282R
3349:2005Sci...308.1435C
3343:(5727): 1435–1439.
3259:2011PNAS..10817308D
3253:(42): 17308–17313.
3206:Veterinary Research
3168:10.1038/nrmicro1025
3048:1986Sci...233..364L
2993:1986PNAS...83.7358S
2677:synaptic plasticity
2653:cerebral ventricles
2633:Alzheimer's disease
2623:Alzheimer's disease
2474:signal transduction
2115:protein translation
1920:cognitive disorders
1858:major prion protein
1088:cuprous ion binding
1008:microtubule binding
839:trigeminal ganglion
5295:10.3233/JAD-130950
4502:10.1093/hmg/ddi228
2249:tertiary structure
2043:-terminal tail. A
2039:tail, and a short
1993:
1575:ENSMUSG00000079037
1280:learning or memory
1218:Biological process
1097:Cellular component
1083:cupric ion binding
1038:copper ion binding
991:Molecular function
8258:
8257:
6221:
6220:
5652:(13): 3307–3316.
5172:(21): 2056–2065.
5038:(11): 1567–1582.
4709:(20): 8866–8875.
4625:10.1002/ana.10658
4495:(15): 2241–2246.
4405:(11): 3255–3264.
3891:(7335): 540–542.
3125:(20): 1516–1526.
3042:(4761): 364–367.
2987:(19): 7358–7362.
2665:neurodegeneration
2338:short-term memory
2261:neurodegeneration
2211:and deprotonated
2024:and a two-strand
1957:; and in humans:
1924:neurodegenerative
1854:
1853:
1850:
1849:
1823:
1822:
1788:
1787:
1763:
1762:
1697:
1696:
1672:
1671:
1626:
1625:
1607:
1606:
1581:
1580:
1562:
1561:
1536:
1535:
1517:
1516:
1465:
1464:
1018:metal ion binding
998:chaperone binding
975:
974:
971:
970:
933:
932:
920:
919:
889:perirhinal cortex
885:entorhinal cortex
858:
857:
756:
755:
655:
654:
482:
481:
478:
477:
70:Ortholog search:
16:(Redirected from
8288:
6248:
6241:
6234:
6225:
6224:
6207:
6192:
6177:
6162:
6147:
6132:
6117:
6102:
6087:
6072:
6057:
6042:
6027:
6012:
5997:
5982:
5967:
5952:
5937:
5922:
5907:
5892:
5877:
5862:
5847:
5832:
5817:
5802:
5787:
5772:
5757:
5737:
5730:
5723:
5714:
5713:
5680:
5679:
5669:
5646:The EMBO Journal
5637:
5631:
5630:
5602:
5596:
5595:
5585:
5553:
5547:
5546:
5544:
5542:
5527:
5521:
5520:
5483:
5474:
5473:
5436:
5427:
5426:
5416:
5376:
5365:
5364:
5354:
5322:
5307:
5306:
5278:
5255:
5254:
5244:
5212:
5206:
5203:
5191:
5181:
5157:
5151:
5150:
5114:
5108:
5107:
5070:
5064:
5063:
5027:
5021:
5020:
4992:
4986:
4985:
4975:
4943:
4937:
4936:
4926:
4886:
4880:
4879:
4861:
4852:(6): 1520–1533.
4837:
4831:
4830:
4812:
4788:
4782:
4781:
4745:
4739:
4738:
4728:
4718:
4694:
4688:
4687:
4651:
4645:
4644:
4608:
4602:
4601:
4565:
4559:
4558:
4521:
4515:
4514:
4504:
4480:
4474:
4473:
4437:
4431:
4430:
4394:
4388:
4387:
4377:
4367:
4350:(5): 2295–2300.
4335:
4329:
4328:
4303:(1–2): 255–265.
4291:
4285:
4284:
4259:(4): 1201–1204.
4248:
4242:
4241:
4231:
4199:
4193:
4192:
4164:
4158:
4157:
4121:
4115:
4114:
4078:
4072:
4071:
4061:
4037:
4031:
4030:
4010:
4004:
4003:
3975:
3966:
3965:
3955:
3946:(7): 1339–1347.
3931:
3925:
3924:
3880:
3874:
3873:
3863:
3823:
3817:
3816:
3806:
3766:
3760:
3759:
3731:
3725:
3724:
3682:
3673:
3667:
3666:
3630:
3624:
3623:
3605:
3596:(5): 1373–1386.
3581:
3575:
3574:
3556:
3532:
3526:
3525:
3515:
3491:
3482:
3481:
3453:
3436:
3435:
3425:
3393:
3387:
3386:
3360:
3332:
3326:
3325:
3297:
3291:
3290:
3280:
3270:
3238:
3232:
3231:
3221:
3197:
3188:
3187:
3151:
3145:
3144:
3134:
3110:
3104:
3103:
3074:
3068:
3067:
3031:
3025:
3024:
3014:
3004:
2972:
2966:
2965:
2937:
2931:
2930:
2919:
2913:
2912:
2901:
2895:
2885:
2874:
2864:
2786:on codon 102 of
2697:dendritic spines
2661:spatial learning
2360:PKA and ERK1/2.
2350:spatial learning
2342:long-term memory
2318:Circadian rhythm
2149:oxidative stress
2111:prion pseudoknot
2086:181 and Asn197.
2064:Signal sequences
1836:
1835:
1807:
1800:
1783:
1767:
1766:
1758:
1706:
1705:
1702:RefSeq (protein)
1692:
1676:
1675:
1667:
1635:
1634:
1611:
1610:
1592:
1591:
1566:
1565:
1547:
1546:
1521:
1520:
1502:
1501:
1471:
1470:
1325:long-term memory
1199:nuclear membrane
1053:protease binding
981:
980:
967:
958:
951:
944:
943:
929:
869:
867:Top expressed in
862:
861:
831:endothelial cell
815:Brodmann area 23
807:
805:Top expressed in
800:
799:
779:
778:
762:
761:
752:
739:
728:
713:
706:
700:
689:
677:
661:
660:
651:
638:
627:
612:
605:
599:
588:
574:
558:
557:
552:
550:PRNP - orthologs
503:
496:
473:
84:
83:
78:
57:
56:
51:
39:
38:
21:
8296:
8295:
8291:
8290:
8289:
8287:
8286:
8285:
8261:
8260:
8259:
8254:
8058:
7852:
7601:
7285:
7008:
6668:
6266:
6252:
6222:
6217:
6214:
6208:
6199:
6193:
6184:
6178:
6169:
6163:
6154:
6148:
6139:
6133:
6124:
6118:
6109:
6103:
6094:
6088:
6079:
6073:
6064:
6058:
6049:
6043:
6034:
6028:
6019:
6013:
6004:
5998:
5989:
5983:
5974:
5968:
5959:
5953:
5944:
5938:
5929:
5923:
5914:
5908:
5899:
5893:
5884:
5878:
5869:
5863:
5854:
5848:
5839:
5833:
5824:
5818:
5809:
5803:
5794:
5788:
5779:
5773:
5764:
5758:
5744:
5741:
5688:
5683:
5638:
5634:
5603:
5599:
5574:10.1038/nbt1271
5554:
5550:
5540:
5538:
5528:
5524:
5484:
5477:
5437:
5430:
5377:
5368:
5323:
5310:
5279:
5258:
5213:
5209:
5194:
5158:
5154:
5115:
5111:
5071:
5067:
5028:
5024:
4993:
4989:
4944:
4940:
4887:
4883:
4838:
4834:
4789:
4785:
4746:
4742:
4695:
4691:
4652:
4648:
4609:
4605:
4566:
4562:
4522:
4518:
4481:
4477:
4454:10.1038/nrg1616
4438:
4434:
4395:
4391:
4336:
4332:
4292:
4288:
4249:
4245:
4200:
4196:
4165:
4161:
4122:
4118:
4079:
4075:
4038:
4034:
4011:
4007:
3976:
3969:
3932:
3928:
3881:
3877:
3824:
3820:
3767:
3763:
3732:
3728:
3680:
3674:
3670:
3635:Nature Medicine
3631:
3627:
3582:
3578:
3533:
3529:
3500:Acta Virologica
3492:
3485:
3454:
3439:
3394:
3390:
3333:
3329:
3298:
3294:
3239:
3235:
3198:
3191:
3162:(11): 861–871.
3152:
3148:
3111:
3107:
3075:
3071:
3032:
3028:
2973:
2969:
2938:
2934:
2921:
2920:
2916:
2903:
2902:
2898:
2886:
2877:
2865:
2856:
2852:
2825:
2816:
2739:In humans, the
2625:
2504:
2498:
2465:
2452:
2419:
2387:
2334:
2292:
2287:
2237:
2161:
2123:
2036:
2013:
1983:
1871:also known as
1845:View/Edit Mouse
1840:View/Edit Human
1803:
1796:
1793:Location (UCSC)
1779:
1775:
1754:
1750:
1746:
1742:
1738:
1734:
1728:
1724:
1720:
1716:
1712:
1688:
1684:
1663:
1657:
1653:
1649:
1645:
1641:
1556:ENSG00000171867
1449:
1213:
1134:plasma membrane
1129:Golgi apparatus
1092:
1028:protein binding
1023:tubulin binding
963:
953:
952:
925:
916:
911:
907:
905:cingulate gyrus
903:
899:
895:
891:
887:
883:
879:
865:
854:
849:
845:
841:
837:
833:
829:
825:
821:
817:
803:
747:
734:
726:
716:
715:
714:
707:
687:
664:Gene location (
646:
633:
625:
615:
614:
613:
606:
584:
561:Gene location (
512:
499:
492:
93:
71:
35:
28:
23:
22:
15:
12:
11:
5:
8294:
8284:
8283:
8278:
8273:
8256:
8255:
8253:
8252:
8247:
8242:
8237:
8232:
8227:
8222:
8217:
8212:
8207:
8202:
8197:
8192:
8187:
8182:
8177:
8172:
8167:
8162:
8157:
8152:
8147:
8142:
8137:
8132:
8127:
8122:
8117:
8112:
8107:
8102:
8097:
8092:
8087:
8082:
8077:
8072:
8066:
8064:
8060:
8059:
8057:
8056:
8051:
8046:
8041:
8036:
8031:
8026:
8021:
8016:
8011:
8006:
8001:
7996:
7991:
7986:
7981:
7976:
7971:
7966:
7961:
7956:
7951:
7946:
7941:
7936:
7931:
7926:
7921:
7916:
7911:
7906:
7901:
7896:
7891:
7886:
7881:
7876:
7871:
7866:
7860:
7858:
7854:
7853:
7851:
7850:
7845:
7836:
7831:
7826:
7821:
7816:
7811:
7806:
7801:
7796:
7791:
7790:
7789:
7784:
7774:
7769:
7764:
7759:
7754:
7749:
7744:
7739:
7734:
7729:
7724:
7719:
7714:
7709:
7703:
7694:
7689:
7688:
7687:
7682:
7672:
7667:
7666:
7665:
7660:
7650:
7645:
7640:
7635:
7630:
7625:
7620:
7615:
7609:
7607:
7603:
7602:
7600:
7599:
7594:
7589:
7584:
7579:
7574:
7569:
7564:
7559:
7554:
7549:
7544:
7539:
7534:
7529:
7524:
7519:
7514:
7513:
7512:
7507:
7497:
7492:
7487:
7482:
7481:
7480:
7475:
7470:
7460:
7455:
7450:
7445:
7440:
7439:
7438:
7433:
7423:
7418:
7413:
7408:
7403:
7398:
7393:
7392:
7391:
7386:
7376:
7370:
7365:
7360:
7355:
7346:
7341:
7340:
7339:
7334:
7329:
7319:
7314:
7309:
7304:
7299:
7293:
7291:
7287:
7286:
7284:
7283:
7278:
7273:
7268:
7263:
7258:
7253:
7248:
7243:
7238:
7233:
7228:
7223:
7218:
7213:
7208:
7203:
7198:
7193:
7188:
7183:
7178:
7173:
7168:
7163:
7158:
7157:
7156:
7151:
7141:
7140:
7139:
7134:
7124:
7119:
7114:
7109:
7104:
7099:
7094:
7089:
7084:
7079:
7074:
7069:
7064:
7063:
7062:
7057:
7047:
7042:
7037:
7032:
7027:
7022:
7016:
7014:
7010:
7009:
7007:
7006:
7001:
6996:
6991:
6986:
6981:
6976:
6971:
6966:
6957:
6952:
6947:
6942:
6937:
6932:
6931:
6930:
6925:
6920:
6915:
6910:
6905:
6895:
6890:
6885:
6880:
6875:
6870:
6869:
6868:
6863:
6853:
6848:
6843:
6838:
6833:
6828:
6823:
6818:
6813:
6812:
6811:
6806:
6801:
6796:
6791:
6786:
6776:
6775:
6774:
6769:
6764:
6754:
6749:
6748:
6747:
6742:
6737:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6692:
6687:
6682:
6676:
6674:
6670:
6669:
6667:
6666:
6661:
6660:
6659:
6654:
6649:
6644:
6639:
6634:
6624:
6619:
6614:
6609:
6604:
6599:
6594:
6593:
6592:
6587:
6582:
6577:
6567:
6562:
6557:
6552:
6547:
6542:
6537:
6532:
6527:
6522:
6521:
6520:
6515:
6505:
6500:
6495:
6490:
6485:
6480:
6475:
6470:
6465:
6460:
6455:
6450:
6445:
6440:
6435:
6434:
6433:
6428:
6418:
6413:
6408:
6403:
6402:
6401:
6396:
6391:
6386:
6376:
6371:
6366:
6365:
6364:
6354:
6349:
6344:
6339:
6334:
6333:
6332:
6327:
6322:
6312:
6307:
6306:
6305:
6300:
6295:
6290:
6285:
6274:
6272:
6268:
6267:
6251:
6250:
6243:
6236:
6228:
6219:
6218:
6216:
6215:
6209:
6202:
6200:
6194:
6187:
6185:
6179:
6172:
6170:
6164:
6157:
6155:
6149:
6142:
6140:
6134:
6127:
6125:
6119:
6112:
6110:
6104:
6097:
6095:
6089:
6082:
6080:
6074:
6067:
6065:
6059:
6052:
6050:
6044:
6037:
6035:
6029:
6022:
6020:
6014:
6007:
6005:
5999:
5992:
5990:
5984:
5977:
5975:
5969:
5962:
5960:
5954:
5947:
5945:
5939:
5932:
5930:
5924:
5917:
5915:
5909:
5902:
5900:
5894:
5887:
5885:
5879:
5872:
5870:
5864:
5857:
5855:
5849:
5842:
5840:
5834:
5827:
5825:
5819:
5812:
5810:
5804:
5797:
5795:
5789:
5782:
5780:
5774:
5767:
5765:
5759:
5752:
5749:
5746:
5745:
5740:
5739:
5732:
5725:
5717:
5711:
5710:
5705:
5695:
5687:
5686:External links
5684:
5682:
5681:
5632:
5613:(2): 620–625.
5597:
5568:(1): 132–138.
5548:
5522:
5495:(6): 405–410.
5475:
5448:(1–2): 89–95.
5428:
5366:
5308:
5289:(2): 227–244.
5256:
5207:
5205:
5204:
5152:
5125:(3): 167–176.
5109:
5082:(5): 387–397.
5065:
5022:
5003:(4): 397–403.
4987:
4938:
4881:
4832:
4783:
4756:(2): 139–144.
4740:
4689:
4662:(2): 116–120.
4646:
4619:(2): 275–276.
4603:
4576:(3): 734–737.
4560:
4533:(6): 688–692.
4516:
4475:
4448:(6): 435–450.
4432:
4389:
4330:
4286:
4243:
4214:(7): 444–449.
4194:
4175:(2): 349–353.
4159:
4132:(2): 173–181.
4116:
4089:(6): 731–742.
4073:
4032:
4005:
3967:
3926:
3875:
3818:
3761:
3736:Molecular Cell
3726:
3691:(2): 282–288.
3668:
3647:10.1038/nm1066
3625:
3576:
3527:
3506:(2): 179–184.
3483:
3464:(2): 673–728.
3437:
3408:(3): 753–758.
3388:
3358:10.1.1.401.781
3327:
3308:(4): 362–374.
3292:
3233:
3189:
3146:
3105:
3086:(2): 758–765.
3069:
3026:
2967:
2948:(4): 315–324.
2932:
2914:
2896:
2875:
2853:
2851:
2848:
2824:
2821:
2815:
2812:
2784:point mutation
2721:phenotypically
2693:excitotoxicity
2624:
2621:
2620:
2619:
2613:
2607:
2570:
2569:
2551:
2534:
2512:prion diseases
2500:Main article:
2497:
2494:
2464:
2461:
2451:
2448:
2418:
2415:
2392:synaptic cleft
2386:
2383:
2333:
2330:
2304:Purkinje cells
2291:
2290:Nervous system
2288:
2286:
2283:
2236:
2233:
2227:change at the
2225:conformational
2202:binding domain
2192:contains five
2179:anchor at its
2160:
2157:
2122:
2121:Ligand-binding
2119:
2076:golden hamster
2049:cell membranes
2034:
2012:
2009:
1982:
1979:
1898:form, and the
1885:nervous system
1852:
1851:
1848:
1847:
1842:
1832:
1831:
1825:
1824:
1821:
1820:
1818:
1816:
1809:
1808:
1801:
1794:
1790:
1789:
1786:
1785:
1771:
1770:
1764:
1761:
1760:
1752:NP_001073592.1
1748:NP_001073591.1
1744:NP_001073590.1
1730:
1729:
1703:
1699:
1698:
1695:
1694:
1680:
1679:
1673:
1670:
1669:
1659:
1658:
1632:
1628:
1627:
1624:
1623:
1615:
1614:
1608:
1605:
1604:
1596:
1595:
1589:
1583:
1582:
1579:
1578:
1570:
1569:
1563:
1560:
1559:
1551:
1550:
1544:
1538:
1537:
1534:
1533:
1525:
1524:
1518:
1515:
1514:
1506:
1505:
1499:
1493:
1492:
1487:
1482:
1478:
1477:
1467:
1466:
1463:
1462:
1451:
1450:
1448:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1387:
1382:
1377:
1372:
1367:
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1221:
1219:
1215:
1214:
1212:
1211:
1206:
1201:
1196:
1191:
1186:
1184:inclusion body
1181:
1176:
1171:
1166:
1161:
1156:
1151:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1100:
1098:
1094:
1093:
1091:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
994:
992:
988:
987:
977:
976:
973:
972:
969:
968:
960:
959:
941:
935:
934:
931:
930:
922:
921:
918:
917:
915:
914:
910:
906:
902:
898:
894:
890:
886:
882:
878:
874:
871:
870:
859:
856:
855:
853:
852:
848:
844:
840:
836:
835:spinal ganglia
832:
828:
824:
820:
816:
812:
809:
808:
796:
795:
787:
776:
770:
769:
766:RNA expression
758:
757:
754:
753:
745:
741:
740:
732:
729:
724:
718:
717:
708:
701:
695:
691:
690:
685:
679:
678:
670:
669:
657:
656:
653:
652:
644:
640:
639:
631:
628:
623:
617:
616:
607:
600:
594:
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589:
582:
576:
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567:
566:
554:
553:
510:
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488:
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475:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
26:
9:
6:
4:
3:
2:
8293:
8282:
8279:
8277:
8274:
8272:
8269:
8268:
8266:
8251:
8248:
8246:
8243:
8241:
8238:
8236:
8233:
8231:
8228:
8226:
8223:
8221:
8218:
8216:
8213:
8211:
8208:
8206:
8203:
8201:
8198:
8196:
8193:
8191:
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8183:
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8171:
8168:
8166:
8163:
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8156:
8153:
8151:
8148:
8146:
8143:
8141:
8138:
8136:
8133:
8131:
8128:
8126:
8123:
8121:
8118:
8116:
8113:
8111:
8108:
8106:
8103:
8101:
8098:
8096:
8093:
8091:
8088:
8086:
8083:
8081:
8078:
8076:
8073:
8071:
8068:
8067:
8065:
8061:
8055:
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8050:
8047:
8045:
8042:
8040:
8037:
8035:
8032:
8030:
8027:
8025:
8022:
8020:
8017:
8015:
8012:
8010:
8007:
8005:
8002:
8000:
7997:
7995:
7992:
7990:
7987:
7985:
7982:
7980:
7977:
7975:
7972:
7970:
7967:
7965:
7962:
7960:
7957:
7955:
7952:
7950:
7947:
7945:
7942:
7940:
7937:
7935:
7932:
7930:
7927:
7925:
7922:
7920:
7917:
7915:
7912:
7910:
7907:
7905:
7902:
7900:
7897:
7895:
7892:
7890:
7887:
7885:
7882:
7880:
7877:
7875:
7872:
7870:
7867:
7865:
7862:
7861:
7859:
7855:
7849:
7846:
7844:
7840:
7837:
7835:
7832:
7830:
7827:
7825:
7822:
7820:
7817:
7815:
7812:
7810:
7807:
7805:
7802:
7800:
7797:
7795:
7792:
7788:
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7758:
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7710:
7707:
7704:
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7698:
7695:
7693:
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7686:
7683:
7681:
7678:
7677:
7676:
7673:
7671:
7668:
7664:
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7649:
7646:
7644:
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7639:
7636:
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7611:
7610:
7608:
7604:
7598:
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7498:
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7488:
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7479:
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7461:
7459:
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7454:
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7449:
7446:
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7441:
7437:
7434:
7432:
7429:
7428:
7427:
7424:
7422:
7419:
7417:
7414:
7412:
7409:
7407:
7404:
7402:
7399:
7397:
7394:
7390:
7387:
7385:
7382:
7381:
7380:
7377:
7374:
7371:
7369:
7366:
7364:
7361:
7359:
7356:
7354:
7350:
7347:
7345:
7342:
7338:
7335:
7333:
7330:
7328:
7325:
7324:
7323:
7320:
7318:
7315:
7313:
7310:
7308:
7305:
7303:
7300:
7298:
7295:
7294:
7292:
7288:
7282:
7279:
7277:
7274:
7272:
7269:
7267:
7264:
7262:
7259:
7257:
7254:
7252:
7249:
7247:
7244:
7242:
7239:
7237:
7234:
7232:
7229:
7227:
7224:
7222:
7219:
7217:
7214:
7212:
7209:
7207:
7204:
7202:
7199:
7197:
7194:
7192:
7189:
7187:
7184:
7182:
7179:
7177:
7174:
7172:
7169:
7167:
7164:
7162:
7159:
7155:
7152:
7150:
7147:
7146:
7145:
7142:
7138:
7135:
7133:
7130:
7129:
7128:
7125:
7123:
7120:
7118:
7115:
7113:
7110:
7108:
7105:
7103:
7100:
7098:
7095:
7093:
7090:
7088:
7085:
7083:
7080:
7078:
7075:
7073:
7070:
7068:
7065:
7061:
7058:
7056:
7053:
7052:
7051:
7048:
7046:
7043:
7041:
7038:
7036:
7033:
7031:
7028:
7026:
7023:
7021:
7018:
7017:
7015:
7011:
7005:
7002:
7000:
6997:
6995:
6992:
6990:
6987:
6985:
6982:
6980:
6977:
6975:
6972:
6970:
6967:
6965:
6961:
6958:
6956:
6953:
6951:
6948:
6946:
6943:
6941:
6938:
6936:
6933:
6929:
6926:
6924:
6921:
6919:
6916:
6914:
6911:
6909:
6906:
6904:
6901:
6900:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6879:
6876:
6874:
6871:
6867:
6864:
6862:
6859:
6858:
6857:
6854:
6852:
6849:
6847:
6844:
6842:
6839:
6837:
6834:
6832:
6829:
6827:
6824:
6822:
6819:
6817:
6814:
6810:
6807:
6805:
6802:
6800:
6797:
6795:
6792:
6790:
6787:
6785:
6782:
6781:
6780:
6777:
6773:
6770:
6768:
6765:
6763:
6760:
6759:
6758:
6755:
6753:
6750:
6746:
6743:
6741:
6738:
6736:
6733:
6732:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6711:
6708:
6706:
6703:
6701:
6698:
6696:
6693:
6691:
6688:
6686:
6683:
6681:
6678:
6677:
6675:
6671:
6665:
6662:
6658:
6655:
6653:
6650:
6648:
6645:
6643:
6640:
6638:
6635:
6633:
6630:
6629:
6628:
6625:
6623:
6620:
6618:
6615:
6613:
6610:
6608:
6605:
6603:
6600:
6598:
6595:
6591:
6588:
6586:
6583:
6581:
6578:
6576:
6573:
6572:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6519:
6516:
6514:
6511:
6510:
6509:
6506:
6504:
6501:
6499:
6496:
6494:
6491:
6489:
6486:
6484:
6481:
6479:
6476:
6474:
6471:
6469:
6466:
6464:
6461:
6459:
6456:
6454:
6451:
6449:
6446:
6444:
6441:
6439:
6436:
6432:
6429:
6427:
6424:
6423:
6422:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6400:
6397:
6395:
6392:
6390:
6387:
6385:
6382:
6381:
6380:
6377:
6375:
6372:
6370:
6367:
6363:
6360:
6359:
6358:
6355:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6331:
6328:
6326:
6323:
6321:
6318:
6317:
6316:
6313:
6311:
6308:
6304:
6301:
6299:
6296:
6294:
6291:
6289:
6286:
6284:
6281:
6280:
6279:
6276:
6275:
6273:
6269:
6264:
6260:
6256:
6249:
6244:
6242:
6237:
6235:
6230:
6229:
6226:
6212:
6206:
6201:
6197:
6191:
6186:
6182:
6176:
6171:
6167:
6161:
6156:
6152:
6146:
6141:
6137:
6131:
6126:
6122:
6116:
6111:
6107:
6101:
6096:
6092:
6086:
6081:
6077:
6071:
6066:
6062:
6056:
6051:
6047:
6041:
6036:
6032:
6026:
6021:
6017:
6011:
6006:
6002:
5996:
5991:
5987:
5981:
5976:
5972:
5966:
5961:
5957:
5951:
5946:
5942:
5936:
5931:
5927:
5921:
5916:
5912:
5906:
5901:
5897:
5891:
5886:
5882:
5876:
5871:
5867:
5861:
5856:
5852:
5846:
5841:
5837:
5831:
5826:
5822:
5816:
5811:
5807:
5801:
5796:
5792:
5786:
5781:
5777:
5771:
5766:
5762:
5756:
5751:
5750:
5747:
5738:
5733:
5731:
5726:
5724:
5719:
5718:
5715:
5709:
5706:
5703:
5699:
5696:
5694:
5690:
5689:
5677:
5673:
5668:
5663:
5659:
5655:
5651:
5647:
5643:
5636:
5628:
5624:
5620:
5616:
5612:
5608:
5601:
5593:
5589:
5584:
5579:
5575:
5571:
5567:
5563:
5559:
5552:
5537:
5533:
5526:
5518:
5514:
5510:
5506:
5502:
5498:
5494:
5490:
5482:
5480:
5471:
5467:
5463:
5459:
5455:
5451:
5447:
5443:
5435:
5433:
5424:
5420:
5415:
5410:
5406:
5402:
5398:
5394:
5390:
5386:
5382:
5375:
5373:
5371:
5362:
5358:
5353:
5348:
5344:
5340:
5336:
5332:
5328:
5321:
5319:
5317:
5315:
5313:
5304:
5300:
5296:
5292:
5288:
5284:
5277:
5275:
5273:
5271:
5269:
5267:
5265:
5263:
5261:
5252:
5248:
5243:
5238:
5234:
5230:
5226:
5222:
5218:
5211:
5201:
5197:
5193:
5192:
5189:
5185:
5180:
5175:
5171:
5167:
5163:
5156:
5148:
5144:
5140:
5136:
5132:
5128:
5124:
5120:
5113:
5105:
5101:
5097:
5093:
5089:
5085:
5081:
5077:
5069:
5061:
5057:
5053:
5049:
5045:
5041:
5037:
5033:
5026:
5018:
5014:
5010:
5006:
5002:
4998:
4991:
4983:
4979:
4974:
4969:
4965:
4961:
4957:
4953:
4949:
4942:
4934:
4930:
4925:
4920:
4916:
4912:
4908:
4904:
4900:
4896:
4892:
4885:
4877:
4873:
4869:
4865:
4860:
4855:
4851:
4847:
4843:
4836:
4828:
4824:
4820:
4816:
4811:
4806:
4802:
4798:
4794:
4787:
4779:
4775:
4771:
4767:
4763:
4759:
4755:
4751:
4744:
4736:
4732:
4727:
4722:
4717:
4712:
4708:
4704:
4700:
4693:
4685:
4681:
4677:
4673:
4669:
4665:
4661:
4657:
4650:
4642:
4638:
4634:
4630:
4626:
4622:
4618:
4614:
4607:
4599:
4595:
4591:
4587:
4583:
4579:
4575:
4571:
4564:
4556:
4552:
4548:
4544:
4540:
4536:
4532:
4528:
4520:
4512:
4508:
4503:
4498:
4494:
4490:
4486:
4479:
4471:
4467:
4463:
4459:
4455:
4451:
4447:
4443:
4436:
4428:
4424:
4420:
4416:
4412:
4408:
4404:
4400:
4393:
4385:
4381:
4376:
4371:
4366:
4361:
4357:
4353:
4349:
4345:
4341:
4334:
4326:
4322:
4318:
4314:
4310:
4306:
4302:
4298:
4290:
4282:
4278:
4274:
4270:
4266:
4262:
4258:
4254:
4247:
4239:
4235:
4230:
4225:
4221:
4217:
4213:
4209:
4205:
4198:
4190:
4186:
4182:
4178:
4174:
4170:
4163:
4155:
4151:
4147:
4143:
4139:
4135:
4131:
4127:
4120:
4112:
4108:
4104:
4100:
4096:
4092:
4088:
4084:
4077:
4069:
4065:
4060:
4055:
4051:
4047:
4043:
4036:
4028:
4024:
4020:
4016:
4009:
4001:
3997:
3993:
3989:
3985:
3981:
3974:
3972:
3963:
3959:
3954:
3949:
3945:
3941:
3937:
3930:
3922:
3918:
3914:
3910:
3906:
3902:
3898:
3894:
3890:
3886:
3879:
3871:
3867:
3862:
3857:
3853:
3849:
3845:
3841:
3837:
3833:
3829:
3822:
3814:
3810:
3805:
3800:
3796:
3792:
3788:
3784:
3780:
3776:
3772:
3765:
3757:
3753:
3749:
3745:
3741:
3737:
3730:
3722:
3718:
3714:
3710:
3706:
3702:
3698:
3694:
3690:
3686:
3679:
3672:
3664:
3660:
3656:
3652:
3648:
3644:
3640:
3636:
3629:
3621:
3617:
3613:
3609:
3604:
3599:
3595:
3591:
3587:
3580:
3572:
3568:
3564:
3560:
3555:
3550:
3546:
3542:
3538:
3531:
3523:
3519:
3514:
3509:
3505:
3501:
3497:
3490:
3488:
3479:
3475:
3471:
3467:
3463:
3459:
3452:
3450:
3448:
3446:
3444:
3442:
3433:
3429:
3424:
3419:
3415:
3411:
3407:
3403:
3399:
3392:
3384:
3380:
3376:
3372:
3368:
3364:
3359:
3354:
3350:
3346:
3342:
3338:
3331:
3323:
3319:
3315:
3311:
3307:
3303:
3296:
3288:
3284:
3279:
3274:
3269:
3264:
3260:
3256:
3252:
3248:
3244:
3237:
3229:
3225:
3220:
3215:
3211:
3207:
3203:
3196:
3194:
3185:
3181:
3177:
3173:
3169:
3165:
3161:
3157:
3150:
3142:
3138:
3133:
3128:
3124:
3120:
3116:
3109:
3101:
3097:
3093:
3089:
3085:
3081:
3073:
3065:
3061:
3057:
3053:
3049:
3045:
3041:
3037:
3030:
3022:
3018:
3013:
3008:
3003:
2998:
2994:
2990:
2986:
2982:
2978:
2971:
2963:
2959:
2955:
2951:
2947:
2943:
2936:
2928:
2924:
2918:
2910:
2906:
2900:
2893:
2889:
2884:
2882:
2880:
2872:
2868:
2863:
2861:
2859:
2854:
2847:
2845:
2841:
2837:
2834:
2830:
2820:
2811:
2809:
2805:
2801:
2797:
2793:
2789:
2785:
2781:
2777:
2773:
2769:
2765:
2761:
2757:
2753:
2749:
2746:
2742:
2737:
2734:
2730:
2726:
2722:
2718:
2714:
2710:
2706:
2702:
2698:
2694:
2690:
2686:
2685:NMDA receptor
2682:
2678:
2674:
2670:
2666:
2662:
2658:
2654:
2650:
2646:
2645:neurotoxicity
2642:
2638:
2634:
2630:
2617:
2614:
2611:
2608:
2605:
2602:
2601:
2600:
2597:
2595:
2591:
2587:
2582:
2580:
2576:
2567:
2563:
2559:
2558:aspartic acid
2555:
2552:
2550:
2546:
2542:
2538:
2535:
2532:
2528:
2524:
2523:glutamic acid
2520:
2517:
2516:
2515:
2513:
2509:
2503:
2493:
2491:
2487:
2486:lipid bilayer
2483:
2477:
2475:
2470:
2460:
2456:
2447:
2445:
2441:
2437:
2433:
2429:
2425:
2417:Immune system
2414:
2412:
2407:
2405:
2401:
2397:
2393:
2382:
2379:
2375:
2374:polymorphisms
2371:
2367:
2366:Down syndrome
2361:
2359:
2355:
2351:
2347:
2343:
2339:
2329:
2327:
2323:
2319:
2315:
2313:
2309:
2305:
2300:
2297:
2282:
2280:
2276:
2275:Polymorphisms
2272:
2270:
2266:
2262:
2257:
2255:
2250:
2246:
2242:
2232:
2230:
2226:
2222:
2218:
2214:
2210:
2207:
2203:
2199:
2195:
2191:
2190:Prion protein
2187:
2185:
2182:
2178:
2174:
2173:cell membrane
2170:
2166:
2156:
2154:
2151:arising from
2150:
2146:
2142:
2138:
2134:
2130:
2128:
2118:
2116:
2112:
2108:
2104:
2103:messenger RNA
2099:
2097:
2093:
2089:
2085:
2081:
2077:
2073:
2069:
2065:
2061:
2057:
2052:
2050:
2046:
2042:
2038:
2030:
2027:
2023:
2019:
2008:
2006:
2002:
2001:chromosome 20
1998:
1991:
1990:Chromosome 20
1987:
1978:
1976:
1972:
1968:
1964:
1960:
1956:
1952:
1948:
1944:
1940:
1936:
1932:
1929:
1925:
1921:
1917:
1913:
1909:
1905:
1901:
1897:
1894:: the normal
1893:
1888:
1886:
1882:
1878:
1874:
1870:
1867:
1863:
1859:
1846:
1841:
1837:
1833:
1830:
1826:
1819:
1817:
1814:
1810:
1806:
1802:
1799:
1795:
1791:
1784:
1782:
1778:
1772:
1768:
1765:
1759:
1757:
1753:
1749:
1745:
1741:
1737:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1704:
1700:
1693:
1691:
1687:
1681:
1677:
1674:
1668:
1666:
1660:
1656:
1652:
1648:
1644:
1640:
1636:
1633:
1631:RefSeq (mRNA)
1629:
1622:
1621:
1616:
1612:
1609:
1603:
1602:
1597:
1593:
1590:
1588:
1584:
1577:
1576:
1571:
1567:
1564:
1558:
1557:
1552:
1548:
1545:
1543:
1539:
1532:
1531:
1526:
1522:
1519:
1513:
1512:
1507:
1503:
1500:
1498:
1494:
1491:
1488:
1486:
1483:
1479:
1476:
1472:
1468:
1461:
1457:
1452:
1446:
1443:
1441:
1438:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1386:
1383:
1381:
1378:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1333:
1331:
1328:
1326:
1323:
1321:
1318:
1316:
1313:
1311:
1308:
1306:
1303:
1301:
1298:
1296:
1293:
1291:
1288:
1286:
1283:
1281:
1278:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1226:
1223:
1222:
1220:
1217:
1216:
1210:
1207:
1205:
1202:
1200:
1197:
1195:
1192:
1190:
1187:
1185:
1182:
1180:
1177:
1175:
1172:
1170:
1167:
1165:
1162:
1160:
1157:
1155:
1152:
1150:
1149:membrane raft
1147:
1145:
1142:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1114:mitochondrion
1112:
1110:
1107:
1105:
1102:
1101:
1099:
1096:
1095:
1089:
1086:
1084:
1081:
1079:
1076:
1074:
1071:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1043:lamin binding
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
995:
993:
990:
989:
986:
985:Gene ontology
982:
978:
966:
961:
957:
950:
945:
942:
940:
936:
928:
923:
912:
908:
904:
900:
896:
892:
888:
884:
880:
876:
875:
872:
868:
863:
860:
851:Pars compacta
850:
846:
842:
838:
834:
830:
826:
822:
818:
814:
813:
810:
806:
801:
798:
797:
794:
792:
788:
786:
785:
781:
780:
777:
775:
771:
767:
763:
759:
751:
746:
742:
738:
733:
723:
719:
712:
705:
699:
692:
684:
680:
676:
671:
667:
662:
658:
650:
645:
641:
637:
632:
622:
618:
611:
604:
598:
591:
587:
581:
577:
573:
568:
564:
559:
555:
551:
547:
543:
539:
535:
531:
527:
523:
519:
515:
507:
502:
495:
490:
485:
474:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
37:
33:
19:
7776:
7696:
7674:
7652:
7499:
7462:
7425:
7378:
7348:
7321:
7143:
7049:
6897:
6626:
6378:
6210:
6195:
6180:
6165:
6150:
6135:
6120:
6105:
6090:
6075:
6060:
6045:
6030:
6015:
6000:
5985:
5970:
5955:
5940:
5925:
5910:
5895:
5880:
5865:
5850:
5835:
5820:
5805:
5790:
5775:
5760:
5649:
5645:
5635:
5610:
5606:
5600:
5565:
5561:
5551:
5539:. Retrieved
5535:
5525:
5492:
5488:
5445:
5441:
5388:
5384:
5337:(2): 35–44.
5334:
5330:
5286:
5282:
5224:
5220:
5210:
5200:ScienceDaily
5199:
5169:
5165:
5155:
5122:
5118:
5112:
5079:
5075:
5068:
5035:
5031:
5025:
5000:
4996:
4990:
4955:
4951:
4941:
4898:
4894:
4884:
4849:
4845:
4835:
4803:(1): 49–57.
4800:
4796:
4786:
4753:
4749:
4743:
4706:
4702:
4692:
4659:
4655:
4649:
4616:
4612:
4606:
4573:
4569:
4563:
4530:
4526:
4519:
4492:
4488:
4478:
4445:
4441:
4435:
4402:
4398:
4392:
4347:
4343:
4333:
4300:
4296:
4289:
4256:
4253:Neuroscience
4252:
4246:
4211:
4207:
4197:
4172:
4168:
4162:
4129:
4125:
4119:
4086:
4082:
4076:
4049:
4045:
4035:
4018:
4014:
4008:
3983:
3979:
3943:
3939:
3929:
3888:
3884:
3878:
3835:
3831:
3821:
3778:
3774:
3764:
3739:
3735:
3729:
3688:
3685:FEBS Letters
3684:
3671:
3638:
3634:
3628:
3593:
3589:
3579:
3547:(1): 69–76.
3544:
3540:
3530:
3503:
3499:
3461:
3457:
3405:
3401:
3391:
3340:
3336:
3330:
3305:
3301:
3295:
3250:
3246:
3236:
3209:
3205:
3159:
3155:
3149:
3122:
3118:
3108:
3083:
3079:
3072:
3039:
3035:
3029:
2984:
2980:
2970:
2945:
2941:
2935:
2926:
2917:
2908:
2899:
2826:
2823:Interactions
2817:
2799:
2787:
2755:
2748:polymorphism
2738:
2728:
2716:
2672:
2656:
2648:
2629:amyloid beta
2626:
2598:
2585:
2583:
2574:
2571:
2507:
2505:
2478:
2466:
2457:
2453:
2420:
2408:
2388:
2377:
2362:
2335:
2325:
2316:
2301:
2293:
2273:
2269:cytotoxicity
2264:
2258:
2238:
2219:-dependent.
2188:
2162:
2131:
2124:
2100:
2080:glycosylated
2058:long before
2053:
2026:antiparallel
2014:
1996:
1994:
1912:mitochondria
1907:
1903:
1895:
1889:
1872:
1865:
1861:
1857:
1855:
1777:NP_001265185
1774:
1733:
1726:NP_001258490
1722:NP_001073592
1718:NP_001073591
1714:NP_001073590
1686:NM_001278256
1683:
1665:NM_001271561
1662:
1655:NM_001080123
1651:NM_001080122
1647:NM_001080121
1618:
1599:
1573:
1554:
1528:
1509:
1489:
1484:
1139:cell surface
789:
782:
748:131,780,349
735:131,751,848
509:External IDs
92:
36:
8281:Amyloidosis
5743:PDB gallery
4021:(15): 462.
3986:: 439–477.
3838:(1): 4005.
3781:(1): 4004.
2833:cochaperone
2829:interaction
2711:events nor
2709:excitotoxic
2669:hippocampus
2579:amino acids
2424:lymphocytes
2404:hippocampus
2396:homeostasis
2254:proteolysis
2209:side-chains
2194:octapeptide
2109:structure (
2105:contains a
2056:amino acids
1756:NP_898902.1
1740:NP_000302.1
1209:postsynapse
487:Identifiers
8265:Categories
6261:(see also
5227:(1): 252.
4958:(1): 1–8.
2894:, May 2017
2873:, May 2017
2850:References
2768:Caucasians
2764:homozygote
2741:methionine
2733:transgenic
2566:methionine
2562:asparagine
2492:function.
2469:cell cycle
2308:cerebellum
2296:transgenic
2229:N-terminus
2181:C-terminal
2107:pseudoknot
1995:The human
1300:metabolism
1295:cell cycle
793:(ortholog)
647:4,701,590
634:4,686,350
530:HomoloGene
5541:1 January
4570:Neurology
4052:: 43–60.
3663:205383483
3353:CiteSeerX
2827:A strong
2725:epileptic
2637:oligomers
2543:102 from
2436:monocytes
2432:platelets
2245:secondary
2206:imidazole
2198:histidine
2141:manganese
2092:disulfide
2078:PrP, two
2037:-terminal
2022:α-helices
2011:Structure
2005:base pair
1916:misfolded
1781:NP_035300
1736:NP_898902
1710:NP_000302
1690:NM_011170
1643:NM_000311
1639:NM_183079
1475:Orthologs
1124:cytoplasm
909:subiculum
881:CA3 field
538:GeneCards
6255:Proteins
5693:GeneCard
5676:12093732
5627:17498662
5592:17195841
5517:20553167
5509:19030774
5470:31070331
5462:23399523
5423:19242475
5361:25343100
5303:23948943
5251:19308092
5188:19923577
5147:20822956
5139:12849238
5104:31976428
5096:11535002
5060:22688729
5052:12420099
5017:15354870
4982:16968391
4933:19242475
4876:26307975
4868:16805766
4819:15450159
4778:24917999
4735:10516306
4684:23642220
4676:16023289
4641:31538672
4633:12891686
4598:11352163
4555:21049364
4547:12796830
4511:15987701
4462:15931169
4427:17164351
4419:17156386
4384:20133875
4317:15837581
4281:42892475
4273:10391428
4189:10521590
4154:37511702
4146:15970215
4111:23409873
4068:14522848
4027:11688751
4000:18558863
3913:21350487
3870:35831291
3813:35831275
3756:34433091
3721:39791520
3655:15272267
3620:24329326
3612:16313516
3571:45647133
3563:11145979
3522:26104335
3478:18391177
3432:11160898
3383:10064966
3375:15933194
3287:21987789
3228:18073096
3212:(4): 9.
3184:20992257
3176:15494743
3141:11357156
2890:–
2869:–
2814:Research
2804:dementia
2687:via the
2635:. These
2482:GPI raft
2463:Cellular
2285:Function
2241:protease
2169:synapses
1900:protease
1892:isoforms
1829:Wikidata
1454:Sources:
1189:dendrite
1109:membrane
897:amygdala
8063:301–350
7857:251–300
7809:CD240CE
7606:201–250
7290:151–200
7013:101–150
5583:2813193
5414:2748841
5393:Bibcode
5352:4204584
5242:2671916
4973:1809729
4924:2748841
4903:Bibcode
4827:2637074
4770:2549468
4726:6782778
4590:9748018
4470:5575951
4375:2836680
4352:Bibcode
4325:2618712
4238:1346338
4229:6151859
4103:9876879
3962:8100741
3921:4399936
3893:Bibcode
3861:9279418
3840:Bibcode
3804:9279362
3783:Bibcode
3713:9280298
3693:Bibcode
3345:Bibcode
3337:Science
3322:7837269
3278:3198368
3255:Bibcode
3100:2877664
3064:3014653
3044:Bibcode
3036:Science
3021:3094007
2989:Bibcode
2962:3755672
2892:Ensembl
2871:Ensembl
2754:129 of
2604:Scrapie
2549:leucine
2545:proline
2484:in the
2411:neurite
2358:kinases
2354:laminin
2306:in the
2279:scrapie
2072:carboxy
2066:in the
2029:β-sheet
1969:(GSS),
1965:(FFI),
1961:(CJD),
1945:(TME),
1931:scrapie
1881:protein
1587:UniProt
1542:Ensembl
1481:Species
1460:QuickGO
1174:cytosol
1164:nucleus
901:decidua
768:pattern
494:Aliases
8070:CD300A
8029:CDw293
7814:CD240D
7675:CD213a
7653:CDw210
7618:CD202b
7592:CDw199
7587:CDw198
7241:CD140b
6673:51–100
5704:(MeSH)
5674:
5667:125391
5664:
5625:
5590:
5580:
5515:
5507:
5468:
5460:
5421:
5411:
5385:Nature
5359:
5349:
5301:
5249:
5239:
5186:
5145:
5137:
5102:
5094:
5058:
5050:
5015:
4980:
4970:
4931:
4921:
4895:Nature
4874:
4866:
4825:
4817:
4797:Neuron
4776:
4768:
4733:
4723:
4682:
4674:
4639:
4631:
4596:
4588:
4553:
4545:
4509:
4468:
4460:
4425:
4417:
4382:
4372:
4323:
4315:
4279:
4271:
4236:
4226:
4187:
4152:
4144:
4109:
4101:
4066:
4025:
3998:
3960:
3919:
3911:
3885:Nature
3868:
3858:
3811:
3801:
3754:
3719:
3711:
3661:
3653:
3618:
3610:
3569:
3561:
3520:
3476:
3430:
3420:
3381:
3373:
3355:
3320:
3285:
3275:
3226:
3182:
3174:
3139:
3098:
3062:
3019:
3012:386716
3009:
2960:
2760:allele
2745:valine
2641:neuron
2590:allele
2564:while
2531:valine
2529:while
2527:lysine
2440:T cell
2434:, and
2370:valine
2346:ataxia
2332:Memory
2312:Doppel
2145:nickel
2143:, and
2133:Copper
2127:ligand
2088:Murine
2070:- and
1973:, and
1914:. The
1815:search
1813:PubMed
1620:P04925
1601:P04156
1497:Entrez
939:BioGPS
518:176640
32:prions
8250:CD350
8245:CD349
8240:CD344
8235:CD340
8230:CD339
8225:CD338
8220:CD337
8215:CD336
8210:CD335
8205:CD334
8200:CD333
8195:CD332
8190:CD331
8185:CD329
8180:CD328
8175:CD327
8170:CD326
8165:CD325
8160:CD324
8155:CD322
8150:CD321
8145:CD320
8140:CD318
8135:CD317
8130:CD316
8125:CD315
8120:CD314
8115:CD312
8110:CD309
8105:CD307
8100:CD306
8095:CD305
8090:CD304
8085:CD303
8080:CD302
8075:CD301
8054:CD299
8049:CD298
8044:CD297
8039:CD295
8034:CD294
8024:CD292
8019:CD290
8014:CD289
8009:CD288
8004:CD286
7999:CD284
7994:CD283
7989:CD282
7984:CD281
7979:CD280
7974:CD279
7969:CD278
7964:CD276
7959:CD275
7954:CD274
7949:CD273
7944:CD272
7939:CD271
7934:CD269
7929:CD268
7924:CD267
7919:CD266
7914:CD265
7909:CD264
7904:CD263
7899:CD262
7894:CD261
7889:CD258
7884:CD257
7879:CD256
7874:CD254
7869:CD253
7864:CD252
7848:CD249
7843:CD248
7839:CD247
7834:CD246
7829:CD244
7824:CD243
7819:CD241
7804:CD239
7799:CD238
7794:CD236
7777:CD235
7772:CD234
7767:CD233
7762:CD230
7757:CD229
7752:CD228
7747:CD227
7742:CD226
7737:CD225
7732:CD224
7727:CD223
7722:CD222
7717:CD221
7712:CD220
7697:CD218
7692:CD217
7670:CD212
7648:CD209
7643:CD208
7638:CD207
7633:CD206
7628:CD205
7623:CD204
7613:CD201
7597:CD200
7582:CD197
7577:CD196
7572:CD195
7567:CD194
7562:CD193
7557:CD192
7552:CD191
7547:CD186
7542:CD185
7537:CD184
7532:CD183
7527:CD182
7522:CD181
7517:CD180
7500:CD179
7495:CD178
7490:CD177
7485:CD174
7463:CD172
7458:CD171
7453:CD170
7448:CD169
7443:CD168
7426:CD167
7421:CD166
7416:CD164
7411:CD163
7406:CD162
7401:CD161
7396:CD160
7379:CD159
7349:CD158
7344:CD157
7322:CD156
7317:CD155
7312:CD154
7307:CD153
7302:CD152
7297:CD151
7281:CD150
7276:CD148
7271:CD147
7266:CD146
7261:CD144
7256:CD143
7251:CD142
7246:CD141
7236:CD138
7231:CD137
7226:CD136
7221:CD135
7216:CD134
7211:CD133
7206:CD132
7201:CD131
7196:CD130
7191:CD129
7186:CD127
7181:CD126
7176:CD125
7171:CD124
7166:CD123
7161:CD122
7144:CD121
7127:CD120
7122:CD119
7117:CD118
7112:CD117
7107:CD116
7102:CD115
7097:CD114
7092:CD113
7087:CD112
7082:CD111
7077:CD110
7072:CD109
7067:CD108
7050:CD107
7045:CD106
7040:CD105
7035:CD104
7030:CD103
7025:CD102
7020:CD101
7004:CD100
5513:S2CID
5466:S2CID
5143:S2CID
5100:S2CID
5056:S2CID
4872:S2CID
4823:S2CID
4774:S2CID
4680:S2CID
4637:S2CID
4594:S2CID
4551:S2CID
4466:S2CID
4423:S2CID
4321:S2CID
4277:S2CID
4150:S2CID
4107:S2CID
3917:S2CID
3717:S2CID
3681:(PDF)
3659:S2CID
3616:S2CID
3567:S2CID
3423:30388
3379:S2CID
3180:S2CID
2844:Hsp90
2840:Hsp70
2772:PSEN1
2752:codon
2541:codon
2213:amide
2186:231.
2175:by a
2165:ionic
2068:amino
2031:, an
1928:ovine
1873:CD230
1530:19122
1490:Mouse
1485:Human
1456:Amigo
791:Mouse
784:Human
731:Start
666:Mouse
630:Start
626:20p13
563:Human
526:97769
6999:CD99
6994:CD98
6989:CD97
6984:CD96
6979:CD95
6974:CD94
6969:CD93
6964:CD92
6960:CD91
6955:CD90
6950:CD89
6945:CD88
6940:CD87
6935:CD86
6898:CD85
6893:CD84
6888:CD83
6883:CD82
6878:CD81
6873:CD80
6856:CD79
6851:CD78
6846:CD74
6841:CD73
6836:CD72
6831:CD71
6826:CD70
6821:CD69
6816:CD68
6779:CD66
6757:CD64
6752:CD63
6730:CD62
6725:CD61
6720:CD59
6715:CD58
6710:CD57
6705:CD56
6700:CD55
6695:CD54
6690:CD53
6685:CD52
6680:CD51
6664:CD50
6627:CD49
6622:CD48
6617:CD47
6612:CD46
6607:CD45
6602:CD44
6597:CD43
6570:CD42
6565:CD41
6560:CD40
6555:CD39
6550:CD38
6545:CD37
6540:CD36
6535:CD35
6530:CD34
6525:CD33
6508:CD32
6503:CD31
6498:CD30
6493:CD29
6488:CD28
6483:CD27
6478:CD26
6473:CD25
6468:CD24
6463:CD23
6458:CD22
6453:CD21
6448:CD20
6443:CD19
6438:CD18
6421:CD16
6416:CD15
6411:CD14
6406:CD13
6379:CD11
6374:CD10
6271:1–50
6211:1y2s
6196:1y15
6181:1xyx
6166:1xyu
6151:1uw3
6136:1tqc
6121:1tqb
6106:1tpx
6091:1qm3
6076:1qm1
6061:1qm0
6046:1qlz
6031:1qlx
6016:1oei
6001:1i4m
5986:1hjn
5971:1hjm
5956:1h0l
5941:1fo7
5926:1fkc
5911:1e1w
5896:1e1u
5881:1e1s
5866:1e1p
5851:1e1j
5836:1e1g
5821:1dx1
5806:1dx0
5791:1dwz
5776:1dwy
5761:1ag2
5672:PMID
5623:PMID
5588:PMID
5543:2007
5505:PMID
5458:PMID
5419:PMID
5357:PMID
5299:PMID
5247:PMID
5184:PMID
5135:PMID
5092:PMID
5048:PMID
5013:PMID
4978:PMID
4929:PMID
4864:PMID
4815:PMID
4766:PMID
4731:PMID
4672:PMID
4629:PMID
4586:PMID
4543:PMID
4507:PMID
4458:PMID
4415:PMID
4380:PMID
4313:PMID
4269:PMID
4234:PMID
4185:PMID
4142:PMID
4099:PMID
4064:PMID
4023:PMID
3996:PMID
3958:PMID
3940:Cell
3909:PMID
3866:PMID
3809:PMID
3752:PMID
3709:PMID
3651:PMID
3608:PMID
3559:PMID
3518:PMID
3474:PMID
3428:PMID
3371:PMID
3318:PMID
3283:PMID
3224:PMID
3172:PMID
3137:PMID
3096:PMID
3060:PMID
3017:PMID
2958:PMID
2800:PRNP
2788:PRNP
2782:. A
2776:APOE
2774:and
2756:PRNP
2729:PRNP
2717:PRNP
2673:PRNP
2657:PRNP
2649:PRNP
2616:Kuru
2594:kuru
2586:PRNP
2575:PRNP
2508:PRNP
2378:PRNP
2326:PRNP
2265:PRNP
2247:and
2137:zinc
2101:PrP
2041:COOH
1997:PRNP
1981:Gene
1971:kuru
1955:deer
1922:and
1869:gene
1866:PRNP
1856:The
1511:5621
843:pons
774:Bgee
722:Band
683:Chr.
621:Band
580:Chr.
542:PRNP
534:7904
514:OMIM
501:PRNP
471:4N9O
467:4KML
463:4E1I
459:4E1H
455:4DGI
451:3NVF
447:3NHC
443:3MD5
439:3MD4
435:3HJX
431:3HJ5
427:3HES
423:3HER
419:3HEQ
415:3HAK
411:3HAF
407:2W9E
403:2M8T
399:2LV1
395:2LSB
391:2LFT
387:2LEJ
383:2LBG
379:2KUN
375:2K1D
371:2IV6
367:2IV5
363:2IV4
359:1QM3
355:1QM2
351:1QM1
347:1QM0
343:1QLZ
339:1QLX
335:1OEI
331:1OEH
327:1I4M
323:1HJN
319:1HJM
315:1H0L
311:1FO7
307:1FKC
303:1E1W
299:1E1U
295:1E1S
291:1E1P
287:1E1J
283:1E1G
281:,%%s
279:4E1I
275:4E1H
271:4DGI
267:3NVF
263:3NHD
259:3NHC
255:3MD5
251:3MD4
247:3HJX
243:3HJ5
239:3HES
235:3HER
231:3HEQ
227:3HAK
223:3HAF
219:2W9E
215:2OL9
211:2LV1
207:2LSB
203:2LFT
199:2LEJ
195:2LBG
191:2KUN
187:2K1D
183:2IV6
179:2IV5
175:2IV4
171:1QM3
167:1QM2
163:1QM1
159:1QM0
155:1QLZ
151:1QLX
147:1OEI
143:1OEH
139:1I4M
135:1HJN
131:1HJM
127:1H0L
123:1FO7
119:1FKC
115:1E1W
111:1E1U
107:1E1S
103:1E1P
99:1E1J
95:1E1G
76:RCSB
73:PDBe
42:PRNP
18:PRNP
6369:CD9
6357:CD8
6352:CD7
6347:CD6
6342:CD5
6337:CD4
6315:CD3
6310:CD2
6283:a-c
6278:CD1
5662:PMC
5654:doi
5615:doi
5611:358
5578:PMC
5570:doi
5497:doi
5450:doi
5446:326
5409:PMC
5401:doi
5389:457
5347:PMC
5339:doi
5291:doi
5237:PMC
5229:doi
5174:doi
5170:361
5127:doi
5084:doi
5040:doi
5036:249
5005:doi
4968:PMC
4960:doi
4956:146
4919:PMC
4911:doi
4899:457
4854:doi
4805:doi
4758:doi
4754:103
4721:PMC
4711:doi
4664:doi
4660:386
4621:doi
4578:doi
4535:doi
4531:250
4497:doi
4450:doi
4407:doi
4370:PMC
4360:doi
4348:107
4305:doi
4261:doi
4224:PMC
4216:doi
4212:326
4177:doi
4134:doi
4130:162
4091:doi
4054:doi
4019:149
3988:doi
3948:doi
3901:doi
3889:470
3856:PMC
3848:doi
3799:PMC
3791:doi
3744:doi
3701:doi
3689:413
3643:doi
3598:doi
3549:doi
3508:doi
3466:doi
3418:PMC
3410:doi
3363:doi
3341:308
3310:doi
3306:245
3273:PMC
3263:doi
3251:108
3214:doi
3164:doi
3127:doi
3123:344
3088:doi
3084:140
3052:doi
3040:233
3007:PMC
2997:doi
2950:doi
2942:DNA
2836:Hop
2750:at
2705:FYN
2701:tau
2689:Fyn
2547:to
2376:in
2221:NMR
2184:Ser
2096:Cys
2084:Asn
1908:PrP
1904:PrP
1896:PrP
1862:PrP
744:End
643:End
546:OMA
522:MGI
66:PDB
8267::
7841:-
6962:-
6303:1E
6298:1D
6293:1B
6288:1A
6257::
5670:.
5660:.
5650:21
5648:.
5644:.
5621:.
5609:.
5586:.
5576:.
5566:25
5564:.
5560:.
5534:.
5511:.
5503:.
5493:29
5491:.
5478:^
5464:.
5456:.
5444:.
5431:^
5417:.
5407:.
5399:.
5387:.
5383:.
5369:^
5355:.
5345:.
5333:.
5329:.
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