301:
278:
200:
175:
559:
552:
3174:
307:
206:
28:
1479:
2167:
Fadista J, Vikman P, Laakso EO, Mollet IG, Esguerra JL, Taneera J, Storm P, Osmark P, Ladenvall C, Prasad RB, Hansson KB, Finotello F, Uvebrant K, Ofori JK, Di
Camillo B, Krus U, Cilio CM, Hansson O, Eliasson L, Rosengren AH, Renström E, Wollheim CB, Groop L (September 2014).
54:
314:
213:
1293:
This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces
3207:
1281:
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of
1298:
stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
3212:
3050:
Wang X, Gong W, Qing H, Geng Y, Wang X, Zhang Y, Peng L, Zhang H, Jiang B (December 2010). "p21-activated kinase 5 inhibits camptothecin-induced apoptosis in colorectal carcinoma cells".
3093:
Zhang DG, Zhang J, Mao LL, Wu JX, Cao WJ, Zheng JN, Pei DS (May 2015). "p21-Activated kinase 5 affects cisplatin-induced apoptosis and proliferation in hepatocellular carcinoma cells".
1328:
plasticity. Physiological level of PAK5 is linked with an overall physical activity in mice as PAK5 deletion in mice has been shown to be associated with an increased activity upon
2948:
Wang XX, Cheng Q, Zhang SN, Qian HY, Wu JX, Tian H, Pei DS, Zheng JN (October 2013). "PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell".
1705:"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
2120:"Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight"
2289:
Zhai J, Qu S, Li X, Zhong J, Chen X, Qu Z, Wu D (August 2015). "miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma".
2818:
He S, Liu M, Zhang W, Xu N, Zhu H (2016). "Over expression of p21-activated kinase 7 associates with lymph node metastasis in esophageal squamous cell cancers".
2905:
Li D, Yao X, Zhang P (November 2013). "The overexpression of P21-activated kinase 5 (PAK5) promotes paclitaxel-chemoresistance of epithelial ovarian cancer".
1237:
long protein(Gene from review). The exon splicing of the murine PAK5 gene generates three transcripts, two of which code an identical 719 amino acids long
862:
843:
136:
1415:, the PAK5 also localizes in mitochondria and phosphorylates BAD at S112. PAK5 inhibits the MARK2/Par1 activity and modulates microtubules dynamics.
1820:"Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain"
1636:
2855:"P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration"
1618:
2991:
Fawdar S, Trotter EW, Li Y, Stephenson NL, Hanke F, Marusiak AA, Edwards ZC, Ientile S, Waszkowycz B, Miller CJ, Brognard J (July 2013).
2481:
Wong LE, Reynolds AB, Dissanayaka NT, Minden A (August 2010). "p120-catenin is a binding partner and substrate for Group B Pak kinases".
1290:
signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP.
2720:
Gu J, Li K, Li M, Wu X, Zhang L, Ding Q, Wu W, Yang J, Mu J, Wen H, Ding Q, Lu J, Hao Y, Chen L, Zhang W, Li S, Liu Y (January 2013).
1093:
1086:
3173:
1747:
2993:"Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer"
1210:
3202:
3153:
1404:
1206:
1601:
51:
2232:"P21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression"
2170:"Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism"
1580:
2673:"P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma"
1333:
1925:
1486:
The 2016 version of this article was updated by an external expert under a dual publication model. The corresponding
1372:
2326:"CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186"
300:
1818:
Pandey A, Dan I, Kristiansen TZ, Watanabe NM, Voldby J, Kajikawa E, Khosravi-Far R, Blagoev B, Mann M (May 2002).
2373:
Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR (March 2012).
1605:
1584:
277:
907:
1459:
in non-small-cell lung cancer lung cancer. PAK5 promotes the cell survival and sensitivity of cancer cells to
199:
174:
888:
2071:"An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis"
116:
2573:
Matenia D, Griesshaber B, Li XY, Thiessen A, Johne C, Jiao J, Mandelkow E, Mandelkow EM (September 2005).
2434:"GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling"
2230:
He S, Feng M, Liu M, Yang S, Yan S, Zhang W, Wang Z, Hu C, Xu Q, Chen L, Zhu H, Xu N (1 December 2014).
2526:"p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD"
313:
212:
3146:
2030:"Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion"
1174:
306:
205:
103:
2069:
Morris DW, Pearson RD, Cormican P, Kenny EM, O'Dushlaine CT, Perreault LP, et al. (June 2014).
1955:
1428:
1361:
1069:
1065:
1010:
1006:
124:
1332:
stimulation. PAK5 has been also thought to be one of genetic variants regulating gene expression (
2771:"Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5"
2575:"PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin"
2622:
Han K, Zhou Y, Gan ZH, Qi WX, Zhang JJ, Fen T, Meng W, Jiang L, Shen Z, Min DL (December 2014).
1061:
1040:
1036:
1002:
981:
977:
1304:
of PAK5 with or without PAK6 deletion in mice has been shown to be associated with a defective
2324:
Zheng J, Li XD, Wang P, Liu XB, Xue YX, Hu Y, Li Z, Li ZQ, Wang ZH, Liu YH (September 2015).
1487:
188:
1910:
PAKs in Human Cancer
Progression: From Inception to Cancer Therapeutic to Future Oncobiology
3139:
3004:
2386:
2243:
2181:
1982:
1368:
1230:
144:
8:
1396:
1301:
1226:
1198:
3008:
2390:
2247:
2185:
1986:
3118:
3075:
3027:
2992:
2973:
2930:
2884:
2795:
2770:
2751:
2697:
2672:
2648:
2623:
2599:
2574:
2506:
2458:
2433:
2409:
2375:"Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking"
2374:
2350:
2325:
2266:
2231:
2204:
2169:
2144:
2119:
2095:
2070:
2005:
1970:
1943:
1885:
1860:
1535:
1500:
1357:
148:
2550:
2525:
1790:
1765:
1680:
1655:
1233:
of the PAK5 gene generates three transcripts, and one of the transcript encodes a 719
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
666:
661:
656:
651:
646:
630:
625:
620:
615:
610:
605:
600:
3110:
3067:
3032:
2965:
2922:
2876:
2835:
2800:
2743:
2702:
2653:
2604:
2555:
2541:
2498:
2463:
2414:
2355:
2306:
2271:
2209:
2149:
2100:
2051:
2010:
1931:
1921:
1890:
1841:
1795:
1726:
1685:
1540:
1522:
1440:
1305:
96:
44:
3122:
2977:
2888:
2755:
2510:
128:
3102:
3079:
3059:
3022:
3012:
2957:
2934:
2914:
2866:
2827:
2790:
2782:
2733:
2692:
2684:
2643:
2635:
2594:
2586:
2545:
2537:
2490:
2453:
2445:
2404:
2394:
2345:
2337:
2298:
2261:
2251:
2199:
2189:
2139:
2135:
2131:
2090:
2082:
2041:
2000:
1990:
1913:
1880:
1872:
1831:
1785:
1777:
1716:
1675:
1667:
1548:
1530:
1514:
393:
324:
268:
223:
1781:
1671:
2769:
Gu X, Wang C, Wang X, Ma G, Li Y, Cui L, Chen Y, Zhao B, Li K (12 January 2015).
2256:
1995:
1353:
368:
152:
2046:
2029:
1766:"PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells"
1656:"PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells"
1641:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1623:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2997:
Proceedings of the
National Academy of Sciences of the United States of America
2379:
Proceedings of the
National Academy of Sciences of the United States of America
2302:
2174:
Proceedings of the
National Academy of Sciences of the United States of America
1917:
1518:
1505:
1448:
1432:
1392:
1201:. Selectivity of PAK5 signaling was recognized by its ability to stimulate the
469:
3106:
3063:
2961:
2918:
1703:
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999).
3196:
2449:
2341:
1859:
Kumar A, Molli PR, Pakala SB, Bui Nguyen TM, Rayala SK, Kumar R (July 2009).
1721:
1704:
1526:
1452:
1287:
587:
558:
551:
3017:
2590:
2399:
2194:
529:
407:
3114:
3071:
3036:
2969:
2926:
2880:
2839:
2804:
2747:
2706:
2657:
2608:
2559:
2502:
2467:
2418:
2359:
2310:
2275:
2213:
2153:
2104:
2055:
2014:
1935:
1894:
1845:
1836:
1819:
1799:
1730:
1689:
1544:
1460:
1444:
1424:
1283:
386:
165:
1552:
1133:
1128:
2086:
1478:
1364:
1329:
1295:
1238:
952:
933:
2722:"A role for p21-activated kinase 7 in the development of gastric cancer"
2688:
1221:
The PAK5 gene, the longest among the PAK family, contains a total of 12
27:
2831:
2738:
2721:
2639:
1234:
285:
182:
132:
2871:
2854:
2786:
2494:
2432:
Li Y, Ke Q, Shao Y, Zhu G, Li Y, Geng N, Jin F, Li F (February 2015).
1876:
1499:
Rakesh Kumar, Rahul
Sanawar, Xiaodong Li, Feng Li (19 December 2016).
73:
3208:
Knowledge articles with corresponding academic peer reviewed articles
2853:
Gong W, An Z, Wang Y, Pan X, Fang W, Jiang B, Zhang H (August 2009).
2118:
Furnari MA, Jobes ML, Nekrasova T, Minden A, Wagner GC (April 2014).
1412:
1321:
1167:
807:
352:
339:
251:
238:
140:
2028:
Nekrasova T, Jobes ML, Ting JH, Wagner GC, Minden A (October 2008).
1411:
at S288 plays a role in cytoskeleton remodeling. In addition to the
107:, PAK7, p21 (RAC1) activated kinase 7, p21 (RAC1) activated kinase 5
1456:
1313:
1117:
2671:
Fang ZP, Jiang BG, Gu XF, Zhao B, Ge RL, Zhang FB (January 2014).
1324:
risk gene, and the pathway is likely to be involved in modulating
1162:
The PAK5 enzyme is one of three members of Group II PAK family of
1388:
1341:
1337:
1325:
1194:
1186:
919:
874:
792:
788:
3213:
Knowledge articles with corresponding articles published in Gene
567:
120:
1971:"Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice"
1969:
Furnari MA, Jobes ML, Nekrasova T, Minden A, Wagner GC (2013).
1436:
1408:
1376:
1309:
1262:
1246:
1170:
1163:
1149:
1101:
829:
3131:
2372:
1455:. There are also examples of gain-of-function activating PAK5
2624:"p21-activated kinase 7 is an oncogene in human osteosarcoma"
2480:
1400:
1317:
1266:
1225:
of which four exons are for 5’-UTR and remaining 8 exons for
1190:
2572:
2523:
1817:
1702:
1189:
as a brain-specific kinase with a predominant expression in
693:
negative regulation of extrinsic apoptotic signaling pathway
2524:
Cotteret S, Jaffer ZM, Beeser A, Chernoff J (August 2003).
2117:
1968:
1270:
1258:
1222:
1156:
2068:
1858:
2990:
2166:
1242:
1202:
2027:
376:
3182:: Crystal Structure Of The Human P21-Activated Kinase 5
1501:"Structure, biochemistry, and biology of PAK kinases"
541:
1763:
1653:
2291:
1764:Dan C, Nath N, Liberto M, Minden A (January 2002).
1654:Dan C, Nath N, Liberto M, Minden A (January 2002).
2947:
1748:"Entrez Gene: PAK7 p21(CDKN1A)-activated kinase 7"
1597:
1595:
1593:
1576:
1574:
1572:
1336:) and its expression associates with an inhibited
1360:. The levels of PAK5 are regulated by miR-129 in
1356:and both PAK5 and Aurora-A are co-upregulated in
753:stress-activated protein kinase signaling cascade
323:
222:
3194:
3049:
1367:, and by the binding of the long non-coding RNA
3092:
2670:
1590:
1569:
2323:
1602:GRCm38: Ensembl release 89: ENSMUSG00000039913
3147:
2852:
2288:
2229:
2817:
2775:International Journal of Biological Sciences
2768:
2621:
1241:while the 2.0-kb transcript is a non-coding
1216:
2431:
1696:
1647:
1581:GRCh38: Ensembl release 89: ENSG00000101349
1352:PAK5 expression is positively regulated by
3154:
3140:
2904:
3026:
3016:
2870:
2794:
2737:
2696:
2647:
2598:
2549:
2457:
2408:
2398:
2349:
2265:
2255:
2203:
2193:
2143:
2094:
2045:
2004:
1994:
1884:
1835:
1789:
1720:
1679:
1534:
2719:
1742:
1740:
1418:
631:protein serine/threonine kinase activity
1907:
3195:
1347:
3135:
1737:
1382:
1146:Serine/threonine-protein kinase PAK 5
758:activation of protein kinase activity
328:
289:
284:
227:
186:
181:
2900:
2898:
2225:
2223:
1472:
1371:differentially expressed (CRNDE) to
2907:Molecular and Cellular Biochemistry
1912:. Vol. 130. pp. 137–209.
1861:"PAK thread from amoeba to mammals"
1813:
1811:
1809:
1759:
1757:
1399:. PAK5-mediated phosphorylation of
13:
1273:interactive binding (CRIB) motif.
1252:
14:
3224:
2895:
2220:
1405:Epithelial-mesenchymal transition
1152:that in humans is encoded by the
3172:
2542:10.1128/mcb.23.16.5526-5539.2003
2483:Journal of Cellular Biochemistry
1865:Journal of Cellular Biochemistry
1806:
1754:
1477:
1403:at S161 and S187 contributes to
743:regulation of mitotic cell cycle
557:
550:
480:lumbar subsegment of spinal cord
312:
305:
299:
276:
211:
204:
198:
173:
26:
3161:
3086:
3043:
2984:
2941:
2859:International Journal of Cancer
2846:
2811:
2762:
2713:
2664:
2615:
2566:
2517:
2474:
2425:
2366:
2317:
2282:
2160:
2111:
2062:
2021:
1962:
1901:
1852:
1441:esophageal squamous cell cancer
1423:PAK5 levels are upregulated in
763:regulation of apoptotic process
748:actin cytoskeleton organization
738:Rho protein signal transduction
2530:Molecular and Cellular Biology
2136:10.1179/1476830513Y.0000000072
1770:Molecular and Cellular Biology
1660:Molecular and Cellular Biology
1629:
1611:
568:More reference expression data
530:More reference expression data
1:
2579:Molecular Biology of the Cell
1782:10.1128/mcb.22.2.567-577.2002
1672:10.1128/MCB.22.2.567-577.2002
1563:
1358:esophageal squamous carcinoma
1286:dynamics, proliferation, and
718:cell population proliferation
297:
196:
3203:Genes on human chromosome 20
2257:10.1371/journal.pone.0113989
1996:10.1371/journal.pone.0061321
1316:. PAK5 is co-expressed with
1180:
7:
2047:10.1016/j.ydbio.2008.07.006
1509:. Gene Wiki Review Series.
1276:
10:
3229:
2677:Acta Pharmacologica Sinica
2628:Cell Biology International
2303:10.1016/j.bbrc.2015.06.108
1918:10.1016/bs.acr.2016.01.002
1519:10.1016/J.GENE.2016.12.014
1407:. PAK5 phosphorylation of
768:regulation of MAPK cascade
504:retinal pigment epithelium
3167:
3107:10.1007/s13277-014-3007-5
3064:10.1007/s13277-010-0071-3
2962:10.1007/s13277-013-0824-x
2919:10.1007/s11010-013-1767-7
1637:"Mouse PubMed Reference:"
1619:"Human PubMed Reference:"
1490:article was published in
1429:hepatocellular carcinomas
1231:Alternative exon splicing
1217:Gene and spliced variants
1193:with a suggested role in
1132:
1127:
1123:
1116:
1100:
1094:Chr 2: 135.92 – 136.23 Mb
1081:
1058:
1054:
1033:
1029:
1022:
999:
995:
974:
970:
963:
950:
946:
931:
927:
918:
905:
901:
886:
882:
873:
860:
856:
841:
837:
828:
813:
806:
802:
786:
778:regulation of cell growth
713:cytoskeleton organization
586:
582:
565:
549:
540:
527:
476:
467:
414:
405:
375:
367:
363:
346:
333:
296:
275:
266:
262:
245:
232:
195:
172:
163:
159:
114:
111:
101:
94:
89:
70:
65:
48:
43:
38:
34:
25:
20:
2450:10.18632/oncotarget.2999
2342:10.18632/oncotarget.4509
2124:Nutritional Neuroscience
2075:Human Molecular Genetics
1466:
1340:-regulated secretion of
488:Rostral migratory stream
3018:10.1073/pnas.1305207110
2591:10.1091/mbc.E05-01-0081
2400:10.1073/pnas.1116560109
2195:10.1073/pnas.1402665111
1908:Kumar R, Li DQ (2016).
1395:and regulates synaptic
1185:The PAK5 was initially
708:protein phosphorylation
611:protein kinase activity
1837:10.1038/sj.onc.1205478
1722:10.1093/dnares/6.5.337
1488:academic peer reviewed
1175:evolutionary conserved
1087:Chr 20: 9.54 – 9.84 Mb
516:superior frontal gyrus
2034:Developmental Biology
1419:Clinical significance
1261:, PAK5 consists of a
512:primary visual cortex
450:cerebellar hemisphere
438:primary visual cortex
418:middle temporal gyrus
189:Chromosome 20 (human)
1496:and can be cited as:
1387:PAK5 phosphorylates
1369:Colorectal neoplasia
1229:(Gene from review).
601:transferase activity
496:primary motor cortex
291:Chromosome 2 (mouse)
66:List of PDB id codes
39:Available structures
3009:2013PNAS..11012426F
2689:10.1038/aps.2013.31
2391:2012PNAS..109.4116S
2248:2014PLoSO...9k3989H
2186:2014PNAS..11113924F
1987:2013PLoSO...861321F
1397:vesicle trafficking
1348:Upstream regulators
728:signal transduction
683:locomotory behavior
508:ganglionic eminence
422:ganglionic eminence
2832:10.3233/CBM-150557
2739:10.1111/febs.12048
2640:10.1002/cbin.10351
2087:10.1093/hmg/ddu025
1383:Downstream targets
908:ENSMUSG00000039913
676:Biological process
640:Cellular component
606:nucleotide binding
594:Molecular function
446:buccal mucosa cell
3190:
3189:
2872:10.1002/ijc.24428
2820:Cancer Biomarkers
2787:10.7150/ijbs.9193
2495:10.1002/jcb.22639
1877:10.1002/jcb.22159
1561:
1560:
1143:
1142:
1139:
1138:
1112:
1111:
1077:
1076:
1048:
1047:
1018:
1017:
989:
988:
959:
958:
940:
939:
914:
913:
895:
894:
869:
868:
850:
849:
798:
797:
733:apoptotic process
578:
577:
574:
573:
536:
535:
523:
522:
461:
460:
454:prefrontal cortex
430:cerebellar vermis
359:
358:
258:
257:
85:
84:
81:
80:
49:Ortholog search:
3220:
3176:
3156:
3149:
3142:
3133:
3132:
3127:
3126:
3090:
3084:
3083:
3047:
3041:
3040:
3030:
3020:
3003:(30): 12426–31.
2988:
2982:
2981:
2945:
2939:
2938:
2902:
2893:
2892:
2874:
2850:
2844:
2843:
2815:
2809:
2808:
2798:
2766:
2760:
2759:
2741:
2726:The FEBS Journal
2717:
2711:
2710:
2700:
2668:
2662:
2661:
2651:
2634:(12): 1394–402.
2619:
2613:
2612:
2602:
2570:
2564:
2563:
2553:
2521:
2515:
2514:
2478:
2472:
2471:
2461:
2429:
2423:
2422:
2412:
2402:
2370:
2364:
2363:
2353:
2336:(28): 25339–55.
2321:
2315:
2314:
2286:
2280:
2279:
2269:
2259:
2227:
2218:
2217:
2207:
2197:
2164:
2158:
2157:
2147:
2115:
2109:
2108:
2098:
2066:
2060:
2059:
2049:
2025:
2019:
2018:
2008:
1998:
1966:
1960:
1959:
1953:
1949:
1947:
1939:
1905:
1899:
1898:
1888:
1856:
1850:
1849:
1839:
1815:
1804:
1803:
1793:
1761:
1752:
1751:
1744:
1735:
1734:
1724:
1700:
1694:
1693:
1683:
1651:
1645:
1644:
1633:
1627:
1626:
1615:
1609:
1599:
1588:
1578:
1556:
1538:
1481:
1473:
1302:Genetic deletion
1177:across species.
1125:
1124:
1096:
1089:
1072:
1052:
1051:
1043:
1027:
1026:
1023:RefSeq (protein)
1013:
993:
992:
984:
968:
967:
944:
943:
925:
924:
899:
898:
880:
879:
854:
853:
835:
834:
804:
803:
584:
583:
570:
561:
554:
547:
546:
532:
492:secondary oocyte
472:
470:Top expressed in
465:
464:
442:Brodmann area 46
434:endothelial cell
426:Brodmann area 23
410:
408:Top expressed in
403:
402:
382:
381:
365:
364:
355:
342:
331:
316:
309:
303:
292:
280:
264:
263:
254:
241:
230:
215:
208:
202:
191:
177:
161:
160:
155:
153:PAK5 - orthologs
106:
99:
76:
63:
62:
57:
36:
35:
30:
18:
17:
3228:
3227:
3223:
3222:
3221:
3219:
3218:
3217:
3193:
3192:
3191:
3186:
3183:
3177:
3163:
3160:
3130:
3091:
3087:
3048:
3044:
2989:
2985:
2946:
2942:
2903:
2896:
2851:
2847:
2816:
2812:
2767:
2763:
2718:
2714:
2669:
2665:
2620:
2616:
2571:
2567:
2536:(16): 5526–39.
2522:
2518:
2479:
2475:
2430:
2426:
2385:(11): 4116–21.
2371:
2367:
2322:
2318:
2287:
2283:
2242:(12): e113989.
2228:
2221:
2180:(38): 13924–9.
2165:
2161:
2116:
2112:
2081:(12): 3316–26.
2067:
2063:
2026:
2022:
1967:
1963:
1951:
1950:
1941:
1940:
1928:
1906:
1902:
1857:
1853:
1830:(24): 3939–48.
1816:
1807:
1762:
1755:
1746:
1745:
1738:
1701:
1697:
1652:
1648:
1635:
1634:
1630:
1617:
1616:
1612:
1600:
1591:
1579:
1570:
1566:
1557:
1498:
1497:
1482:
1469:
1421:
1385:
1350:
1344:in INS1 cells.
1279:
1255:
1253:Protein domains
1219:
1183:
1134:View/Edit Mouse
1129:View/Edit Human
1092:
1085:
1082:Location (UCSC)
1068:
1064:
1060:
1039:
1035:
1009:
1005:
1001:
980:
976:
889:ENSG00000101349
782:
688:phosphorylation
671:
635:
626:protein binding
616:kinase activity
566:
556:
555:
528:
519:
514:
510:
506:
502:
498:
494:
490:
486:
482:
468:
457:
452:
448:
444:
440:
436:
432:
428:
424:
420:
406:
350:
337:
329:
319:
318:
317:
310:
290:
267:Gene location (
249:
236:
228:
218:
217:
216:
209:
187:
164:Gene location (
115:
102:
95:
72:
50:
12:
11:
5:
3226:
3216:
3215:
3210:
3205:
3188:
3187:
3185:
3184:
3178:
3171:
3168:
3165:
3164:
3159:
3158:
3151:
3144:
3136:
3129:
3128:
3101:(5): 3685–91.
3095:Tumour Biology
3085:
3052:Tumour Biology
3042:
2983:
2950:Tumour Biology
2940:
2913:(1–2): 191–9.
2894:
2845:
2810:
2761:
2712:
2663:
2614:
2585:(9): 4410–22.
2565:
2516:
2489:(5): 1244–54.
2473:
2444:(6): 4345–56.
2424:
2365:
2316:
2281:
2219:
2159:
2110:
2061:
2020:
1961:
1952:|journal=
1926:
1900:
1851:
1805:
1753:
1736:
1695:
1646:
1628:
1610:
1589:
1567:
1565:
1562:
1559:
1558:
1485:
1483:
1476:
1468:
1465:
1449:ovarian cancer
1433:gastric cancer
1420:
1417:
1393:Synaptojanin-1
1384:
1381:
1362:hepatocacinoma
1349:
1346:
1278:
1275:
1254:
1251:
1245:with retained
1227:protein coding
1218:
1215:
1199:neuronal cells
1182:
1179:
1141:
1140:
1137:
1136:
1131:
1121:
1120:
1114:
1113:
1110:
1109:
1107:
1105:
1098:
1097:
1090:
1083:
1079:
1078:
1075:
1074:
1056:
1055:
1049:
1046:
1045:
1031:
1030:
1024:
1020:
1019:
1016:
1015:
997:
996:
990:
987:
986:
972:
971:
965:
961:
960:
957:
956:
948:
947:
941:
938:
937:
929:
928:
922:
916:
915:
912:
911:
903:
902:
896:
893:
892:
884:
883:
877:
871:
870:
867:
866:
858:
857:
851:
848:
847:
839:
838:
832:
826:
825:
820:
815:
811:
810:
800:
799:
796:
795:
784:
783:
781:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
723:cell migration
720:
715:
710:
705:
700:
695:
690:
685:
679:
677:
673:
672:
670:
669:
664:
659:
654:
649:
643:
641:
637:
636:
634:
633:
628:
623:
618:
613:
608:
603:
597:
595:
591:
590:
580:
579:
576:
575:
572:
571:
563:
562:
544:
538:
537:
534:
533:
525:
524:
521:
520:
518:
517:
513:
509:
505:
501:
500:primary oocyte
497:
493:
489:
485:
481:
477:
474:
473:
462:
459:
458:
456:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
412:
411:
399:
398:
390:
379:
373:
372:
369:RNA expression
361:
360:
357:
356:
348:
344:
343:
335:
332:
327:
321:
320:
311:
304:
298:
294:
293:
288:
282:
281:
273:
272:
260:
259:
256:
255:
247:
243:
242:
234:
231:
226:
220:
219:
210:
203:
197:
193:
192:
185:
179:
178:
170:
169:
157:
156:
113:
109:
108:
100:
92:
91:
87:
86:
83:
82:
79:
78:
68:
67:
59:
58:
47:
41:
40:
32:
31:
23:
22:
9:
6:
4:
3:
2:
3225:
3214:
3211:
3209:
3206:
3204:
3201:
3200:
3198:
3181:
3175:
3170:
3169:
3166:
3157:
3152:
3150:
3145:
3143:
3138:
3137:
3134:
3124:
3120:
3116:
3112:
3108:
3104:
3100:
3096:
3089:
3081:
3077:
3073:
3069:
3065:
3061:
3058:(6): 575–82.
3057:
3053:
3046:
3038:
3034:
3029:
3024:
3019:
3014:
3010:
3006:
3002:
2998:
2994:
2987:
2979:
2975:
2971:
2967:
2963:
2959:
2956:(5): 2721–9.
2955:
2951:
2944:
2936:
2932:
2928:
2924:
2920:
2916:
2912:
2908:
2901:
2899:
2890:
2886:
2882:
2878:
2873:
2868:
2865:(3): 548–55.
2864:
2860:
2856:
2849:
2841:
2837:
2833:
2829:
2825:
2821:
2814:
2806:
2802:
2797:
2792:
2788:
2784:
2780:
2776:
2772:
2765:
2757:
2753:
2749:
2745:
2740:
2735:
2731:
2727:
2723:
2716:
2708:
2704:
2699:
2694:
2690:
2686:
2682:
2678:
2674:
2667:
2659:
2655:
2650:
2645:
2641:
2637:
2633:
2629:
2625:
2618:
2610:
2606:
2601:
2596:
2592:
2588:
2584:
2580:
2576:
2569:
2561:
2557:
2552:
2547:
2543:
2539:
2535:
2531:
2527:
2520:
2512:
2508:
2504:
2500:
2496:
2492:
2488:
2484:
2477:
2469:
2465:
2460:
2455:
2451:
2447:
2443:
2439:
2435:
2428:
2420:
2416:
2411:
2406:
2401:
2396:
2392:
2388:
2384:
2380:
2376:
2369:
2361:
2357:
2352:
2347:
2343:
2339:
2335:
2331:
2327:
2320:
2312:
2308:
2304:
2300:
2296:
2292:
2285:
2277:
2273:
2268:
2263:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2226:
2224:
2215:
2211:
2206:
2201:
2196:
2191:
2187:
2183:
2179:
2175:
2171:
2163:
2155:
2151:
2146:
2141:
2137:
2133:
2130:(3): 109–15.
2129:
2125:
2121:
2114:
2106:
2102:
2097:
2092:
2088:
2084:
2080:
2076:
2072:
2065:
2057:
2053:
2048:
2043:
2040:(1): 95–108.
2039:
2035:
2031:
2024:
2016:
2012:
2007:
2002:
1997:
1992:
1988:
1984:
1981:(4): e61321.
1980:
1976:
1972:
1965:
1957:
1945:
1937:
1933:
1929:
1927:9780128047897
1923:
1919:
1915:
1911:
1904:
1896:
1892:
1887:
1882:
1878:
1874:
1871:(4): 579–85.
1870:
1866:
1862:
1855:
1847:
1843:
1838:
1833:
1829:
1825:
1821:
1814:
1812:
1810:
1801:
1797:
1792:
1787:
1783:
1779:
1776:(2): 567–77.
1775:
1771:
1767:
1760:
1758:
1749:
1743:
1741:
1732:
1728:
1723:
1718:
1715:(5): 337–45.
1714:
1710:
1706:
1699:
1691:
1687:
1682:
1677:
1673:
1669:
1666:(2): 567–77.
1665:
1661:
1657:
1650:
1642:
1638:
1632:
1624:
1620:
1614:
1607:
1603:
1598:
1596:
1594:
1586:
1582:
1577:
1575:
1573:
1568:
1554:
1550:
1546:
1542:
1537:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1507:
1502:
1495:
1494:
1489:
1484:
1480:
1475:
1474:
1471:
1464:
1462:
1458:
1454:
1453:breast cancer
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1416:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1380:
1378:
1374:
1370:
1366:
1363:
1359:
1355:
1345:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1297:
1291:
1289:
1288:cell survival
1285:
1274:
1272:
1268:
1264:
1260:
1250:
1248:
1244:
1240:
1236:
1232:
1228:
1224:
1214:
1212:
1208:
1204:
1200:
1196:
1192:
1188:
1178:
1176:
1172:
1169:
1165:
1160:
1158:
1155:
1151:
1147:
1135:
1130:
1126:
1122:
1119:
1115:
1108:
1106:
1103:
1099:
1095:
1091:
1088:
1084:
1080:
1073:
1071:
1067:
1063:
1057:
1053:
1050:
1044:
1042:
1038:
1032:
1028:
1025:
1021:
1014:
1012:
1008:
1004:
998:
994:
991:
985:
983:
979:
973:
969:
966:
964:RefSeq (mRNA)
962:
955:
954:
949:
945:
942:
936:
935:
930:
926:
923:
921:
917:
910:
909:
904:
900:
897:
891:
890:
885:
881:
878:
876:
872:
865:
864:
859:
855:
852:
846:
845:
840:
836:
833:
831:
827:
824:
821:
819:
816:
812:
809:
805:
801:
794:
790:
785:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
680:
678:
675:
674:
668:
665:
663:
660:
658:
655:
653:
652:mitochondrion
650:
648:
645:
644:
642:
639:
638:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
598:
596:
593:
592:
589:
588:Gene ontology
585:
581:
569:
564:
560:
553:
548:
545:
543:
539:
531:
526:
515:
511:
507:
503:
499:
495:
491:
487:
483:
479:
478:
475:
471:
466:
463:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
416:
413:
409:
404:
401:
400:
397:
395:
391:
389:
388:
384:
383:
380:
378:
374:
370:
366:
362:
354:
349:
345:
341:
336:
326:
322:
315:
308:
302:
295:
287:
283:
279:
274:
270:
265:
261:
253:
248:
244:
240:
235:
225:
221:
214:
207:
201:
194:
190:
184:
180:
176:
171:
167:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
110:
105:
98:
93:
88:
77:
75:
69:
64:
61:
60:
56:
53:
46:
42:
37:
33:
29:
24:
19:
16:
3179:
3098:
3094:
3088:
3055:
3051:
3045:
3000:
2996:
2986:
2953:
2949:
2943:
2910:
2906:
2862:
2858:
2848:
2826:(2): 203–9.
2823:
2819:
2813:
2781:(2): 230–7.
2778:
2774:
2764:
2732:(1): 46–55.
2729:
2725:
2715:
2680:
2676:
2666:
2631:
2627:
2617:
2582:
2578:
2568:
2533:
2529:
2519:
2486:
2482:
2476:
2441:
2437:
2427:
2382:
2378:
2368:
2333:
2329:
2319:
2297:(1): 161–7.
2294:
2290:
2284:
2239:
2235:
2177:
2173:
2162:
2127:
2123:
2113:
2078:
2074:
2064:
2037:
2033:
2023:
1978:
1974:
1964:
1909:
1903:
1868:
1864:
1854:
1827:
1823:
1773:
1769:
1712:
1709:DNA Research
1708:
1698:
1663:
1659:
1649:
1640:
1631:
1622:
1613:
1510:
1504:
1492:
1491:
1470:
1461:chemotherapy
1445:colon cancer
1425:osteosarcoma
1422:
1409:p120-catenin
1386:
1365:cancer cells
1351:
1300:
1292:
1284:cytoskeletal
1280:
1256:
1220:
1184:
1161:
1153:
1145:
1144:
1070:NP_001347313
1066:NP_001347311
1059:
1034:
1011:NM_001360384
1007:NM_001360382
1000:
975:
951:
932:
906:
887:
861:
842:
822:
817:
392:
385:
351:136,229,887
338:135,923,024
112:External IDs
71:
15:
3162:PDB gallery
2683:(1): 82–8.
1330:amphetamine
1296:microtubule
1257:Similar to
1239:polypeptide
1235:amino acids
1211:ERK kinases
773:cell growth
662:nucleoplasm
621:ATP binding
330:2|2 F3
90:Identifiers
3197:Categories
2438:Oncotarget
2330:Oncotarget
1608:, May 2017
1587:, May 2017
1564:References
1306:locomotion
1203:JNK kinase
1197:growth in
396:(ortholog)
250:9,839,076
237:9,537,370
133:HomoloGene
1954:ignored (
1944:cite book
1553:Q38779105
1527:0378-1119
1513:: 20–31.
1457:mutations
1413:cytoplasm
1322:psychosis
1181:Discovery
1168:threonine
1062:NP_766446
1041:NP_817127
1037:NP_065074
1003:NM_172858
982:NM_177990
978:NM_020341
808:Orthologs
647:cytoplasm
141:GeneCards
3123:11752910
3115:25560489
3072:20567954
3037:23836671
2978:15521185
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