1573:. When a muscle becomes injured (thus requiring regeneration) Wnt5a, Wnt5b, and Wnt7a are increased in expression. As the muscle completes repair Wnt7b and Wnt3a are increased as well. This patterning of Wnt signalling expression in muscle cell repair induces the differentiation of the progenitor cells, which reduces the number of available satellite cells. Wnt plays a crucial role in satellite cell regulation and skeletal muscle aging and also regeneration. Wnts are known to active the expression of Myf5 and MyoD by Wnt1 and Wnt7a. Wnt4, Wnt5, and Wnt6 function to increase the expression of both of the regulatory factors but at a more subtle level. Additionally, MyoD increases Wnt3a when myoblasts undergo differentiation. Whether MyoD is activated by Wnt via cis-regulation direct targeting or through indirect physiological pathways remains to be elucidated.
311:
288:
3823:
210:
185:
1486:
1509:. Cell cycle arrest (in which myoblasts would indicate the conclusion of myogenesis) is dependent on the continuous and stable repression of the D1 cyclin. Both MyoD and pRb are necessary for the repression of cyclin D1, but rather than acting directly on cyclin D1, they act on Fra-1 which is immediately early of cyclin D1. MyoD and pRb are both necessary for repressing Fra-1 (and thus cyclin D1) as either MyoD or pRb on its own is not sufficient alone to induce cyclin D1 repression and thus cell cycle arrest. In an intronic
1343:, but expression of MyoD is activated in response to exercise or muscle tissue damage. The effect of MyoD on satellite cells is dose-dependent; high MyoD expression represses cell renewal, promotes terminal differentiation and can induce apoptosis. Although MyoD marks myoblast commitment, muscle development is not dramatically ablated in mouse mutants lacking the MyoD gene. This is likely due to functional redundancy from Myf5 and/or Mrf4. Nevertheless, the combination of MyoD and Myf5 is vital to the success of
562:
1611:
1633:
conjunction with a placeholding "putative pioneer factor" which helps to establish and maintain a both of them in a specific and inactive conformation. Upon the removal or inactivation on the placeholder protein bound to the enhancer, the recruitment of the additional group of transcription factors that help to positively regulate enhancer activity is permitted and this results in the MyoD-transcription factor-enhancer complex to assume a transcriptionally active state.
317:
216:
1482:
depleted myoblasts that are treated with exogenous MyoD, myoblastic differentiation is successfully restored. In one model of Setdb1 action on MyoD, Setdb1 represses an inhibitor of MyoD. This unidentified inhibitor likely acts competitively against MyoD during typical cellular proliferation. Evidence for this model is that reduction of Setdb1 results in direct inhibition of myoblast differentiation which may be caused by the release of the unknown MyoD inhibitor.
38:
1368:) and found MyoD converted them to myogenic cells. The following year, the same research team performed several tests to determine both the structure and function of the protein, confirming their initial proposal that the active site of the protein consisted of the helix loop helix (now referred to as
1607:. NFATc1 physically disrupts the interaction between MyoD and p300. This establishes the molecular mechanism by which fiber types transition in vivo through exercise with opposing roles for NFATc1 and MyoD. NFATc1 controls this balance by physical inhibition of MyoD in slow-twitch muscle fiber types.
1619:
The histone deacetyltransferase p300 functions with MyoD in an interaction that is essential for the myotube generation from fibroblasts that is mediated by MyoD. Recruitment of p300 is the rate-limiting process in the conversion of fibroblasts to myotubes. In addition to p300, MyoD is also known to
1632:
to the enhancer that is bound with and this allows for the activation of muscle gene that is condition-specific and established by MyoD recruitment. Endogenous p300 though, is necessary for MyoD functioning by acting as an essential coactivator. MyoD associatively binds to the enhancer region in
1614:
MyoD works with a transient placeholder protein that functions to prevent other transcription factors from binding to the DNA and also retains an inactive conformation for the DNA. Once the placeholder is removed (or possibly deactivated) the necessary transcription factors are free to bind and
1602:
is a transcription factor that regulates composition of fiber type and the fast-to-slow twitch transition resulting from aerobic exercise requires the expression of NFATc1. MyoD expression is a key transcription factor in fast twitch fibers which is inhibited by NFATc1 in oxidative fiber types.
1481:
is required to maintain MyoD expression within the cell. Setdb1 appears to be necessary to maintain both MyoD expression and also genes that are specific to muscle tissues because reduction of Setdb1 expression results in a severe delay of myoblast differentiation and determination. In Setdb1
1513:
of Fra-1 there were two conserved MyoD binding sites discovered. There is cooperative action of MyoD and pRb at the Fra-1 intronic enhancer that suppresses the enhancer, therefore suppressing cyclin D1 and ultimately resulting in cell cycle arrest for terminally differentiated myoblasts.
64:
1473:
HDAC1. The consequence of this coactivator/corepressor recruitment is silenced promoting regions on muscle genes. When the kinase MSK1 phosphorylates KAP1, the corepressors previously bound to the scaffold are released allowing MyoD and Mef2 to activate transcription.
1355:
MyoD was cloned by a functional assay for muscle formation reported in Cell in 1987 by Davis, Weintraub, and Lassar. It was first described as a nuclear phosphoprotein in 1988 by
Tapscott, Davis, Thayer, Cheng, Weintraub, and Lassar in
324:
223:
3822:
3586:
Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B (February 1993). "Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation".
3863:
1449:
proliferation. While not completely understood, MyoD is now thought to function as a major myogenesis controller in an on/off switch association mediated by KAP1 (KRAB -associated protein 1)
2759:
Bengal E, Ransone L, Scharfmann R, Dwarki VJ, Tapscott SJ, Weintraub H, et al. (February 1992). "Functional antagonism between c-Jun and MyoD proteins: a direct physical association".
3233:
Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, et al. (March 2004). "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis".
2013:
Tapscott SJ, Davis RL, Thayer MJ, Cheng PF, Weintraub H, Lassar AB (Oct 1988). "MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts".
1603:
NFATc1 works to inhibit MyoD via a physical interaction with the MyoD N-terminal activation domain resulting in inhibited recruitment of the necessary transcriptional coactivator
3856:
4785:
2371:"Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis"
9275:
3849:
5284:
2056:
Davis RL, Cheng PF, Lassar AB, Thayer M, Tapscott S, Weintraub H (1989). "MyoD and achaete-scute: 4-5 amino acids distinguishes myogenesis from neurogenesis".
1489:
Evidence suggests that Setdb1 inhibits a repressor of MyoD and this is the mechanism through which MyoD expression is retained in differentiated myoblasts.
1030:
7491:
3453:
Ling MT, Chiu YT, Lee TK, Leung SC, Fung MK, Wang X, et al. (September 2008). "Id-1 induces proteasome-dependent degradation of the HBX protein".
3093:"Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD"
1011:
146:
1917:
Rudnicki MA, Schnegelsberg PN, Stead RH, Braun T, Arnold HH, Jaenisch R (Dec 1993). "MyoD or Myf-5 is required for the formation of skeletal muscle".
6169:
5191:
5186:
5181:
4830:
1339:
MyoD is one of the earliest markers of myogenic commitment. MyoD is expressed at extremely low and essentially undetectable levels in quiescent
4815:
4501:
2856:"Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C"
2712:"Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C"
1814:
1796:
5324:
2134:"MyoD protein is differentially accumulated in fast and slow skeletal muscle fibres and required for normal fibre type balance in rodents"
1561:
In typical adult muscles in a resting condition (absence of physiological stress) the specific Wnt family proteins that are expressed are
9119:
9103:
3922:
2612:"PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB"
5176:
1230:
7892:
7887:
7882:
7877:
7872:
4961:
4954:
4949:
4937:
4932:
4927:
4922:
4917:
4845:
3831:: CRYSTAL STRUCTURE OF MYOD BHLH DOMAIN BOUND TO DNA: PERSPECTIVES ON DNA RECOGNITION AND IMPLICATIONS FOR TRANSCRIPTIONAL ACTIVATION
1237:
8841:
6964:
8052:
8047:
7997:
7987:
7967:
7952:
7932:
7857:
7837:
6979:
6974:
5640:
1903:
7208:
7166:
7161:
7156:
7094:
6928:
6716:
6667:
6662:
4709:
4699:
1376:. MyoD has since been an active area of research as still relatively little is known concerning many aspects of its function.
9295:
3802:
3186:"A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program"
1388:
cells to a skeletal myoblast lineage, and then to regulate that continued state. MyoD may also regulate muscle repair. MyoD
2954:"Direct inhibition of G(1) cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation"
1779:
1674:
61:
1860:
Davis RL, Weintraub H, Lassar AB (Dec 1987). "Expression of a single transfected cDNA converts fibroblasts to myoblasts".
8604:
4496:
4068:
1758:
1522:
Wnt signalling from adjacent tissues has been shown to induce cells in somites that receive these Wnt signals to express
8873:
7772:
5859:
3414:"The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein"
5317:
5312:
5240:
5230:
4107:
4097:
3932:
1558:
have also been implicated in promoting myogenesis in the somite; the latter signals may act primarily through Myod.
1501:(pRb) to cause cell cycle arrest in the terminally differentiated myoblasts. This is done through regulation of the
310:
5235:
5149:
3712:
Maleki SJ, Royer CA, Hurlburt BK (June 1997). "MyoD-E12 heterodimers and MyoD-MyoD homodimers are equally stable".
8171:
5447:
5437:
4038:
3917:
2463:"Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer"
1783:
1762:
1415:). CDKs are in turn inhibited by p21. Thus MyoD enhances its own activity in the cell in a feedforward manner.
287:
9300:
5802:
5442:
5137:
2563:"PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C"
1372:) for dimerization and a basic site upstream of this bHLH region facilitated DNA binding only once it became a
1360:. The researchers expressed the complementary DNA (cDNA) of the murine MyoD protein in a different cell lines (
1075:
9084:
9079:
8230:
5142:
209:
184:
3373:"Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc"
2322:"Setdb1 Is Required for Myogenic Differentiation of C2C12 Myoblast Cells via Maintenance of MyoD Expression"
1056:
9179:
7515:
5665:
5218:
5208:
3673:"Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts"
126:
1966:"Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish"
7684:
7679:
7230:
5307:
5225:
5213:
4289:
3003:"Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4"
1642:
1604:
1531:
1458:
1421:
MyoD is also an important effector for the fast-twitch muscle fiber (types IIA, IIX, and IIB) phenotype.
1309:
323:
222:
5420:
4418:
1584:
is a positive cofactor of MyoD, as it cooperates with MyoD at inducing the transcriptional activity of
1457:(a myocyte transcription enhancer factor). Here, it serves as a scaffold and recruits the coactivators
316:
215:
8836:
5717:
5702:
5685:
5680:
5675:
5670:
5581:
5556:
5432:
5344:
5334:
4491:
3964:
3795:
1722:
1668:
3841:
113:
8578:
8213:
7729:
7302:
7141:
6076:
6071:
6056:
5531:
5506:
5388:
5339:
5132:
4523:
3989:
3753:
134:
9305:
8943:
6984:
6301:
5415:
5403:
3539:"Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins"
3537:
Lenormand JL, Benayoun B, Guillier M, Vandromme M, Leibovitch MP, Leibovitch SA (February 1997).
3142:"Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis"
2610:
Micheli L, Leonardi L, Conti F, Maresca G, Colazingari S, Mattei E, et al. (February 2011).
1412:
3630:
Froeschlé A, Alric S, Kitzmann M, Carnac G, Auradé F, Rochette-Egly C, et al. (July 1998).
1213:
1192:
1166:
1145:
9074:
7121:
7116:
5511:
5408:
5203:
5164:
4227:
3876:
1716:
1543:
1498:
2422:"[Interactions of proliferation and differentiation signaling pathways in myogenesis]"
9066:
8626:
5425:
5361:
5356:
5169:
4245:
2232:"A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation"
1494:
1418:
Sustained MyoD expression is necessary for retaining the expression of muscle-related genes.
1403:
for terminal cell cycle arrest in differentiated myocytes) by enhancing the transcription of
198:
3632:"Retinoic acid receptors and muscle b-HLH proteins: partners in retinoid-induced myogenesis"
3291:"Differential interactions of Id proteins with basic-helix-loop-helix transcription factors"
8647:
8639:
6477:
5959:
5484:
5479:
5474:
5154:
5037:
3872:
3788:
3671:
Kataoka Y, Matsumura I, Ezoe S, Nakata S, Takigawa E, Sato Y, et al. (November 2003).
3242:
2022:
1656:
1547:
1430:
1320:
act sequentially in myogenic differentiation. Vertebrate MRF family members include MyoD1,
1317:
154:
3140:
Puri PL, Iezzi S, Stiegler P, Chen TT, Schiltz RL, Muscat GE, et al. (October 2001).
3050:
Reynaud EG, Leibovitch MP, Tintignac LA, Pelpel K, Guillier M, Leibovitch SA (June 2000).
669:
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
8:
8961:
8665:
8361:
6564:
5769:
5351:
5329:
5302:
5264:
5198:
2663:"NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity"
2183:"NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity"
1510:
1470:
1442:
1305:
3749:
3246:
2026:
8499:
3612:
3519:
3266:
3027:
3002:
2978:
2953:
2802:
Polesskaya A, Naguibneva I, Duquet A, Bengal E, Robin P, Harel-Bellan A (August 2001).
2784:
2687:
2662:
2638:
2611:
2587:
2562:
2538:
2511:
2487:
2462:
2397:
2370:
2346:
2321:
2256:
2231:
2207:
2182:
2163:
2109:
2084:
1990:
1965:
1942:
1885:
158:
3563:
3538:
3506:
3489:
3348:
3331:
3210:
3185:
3158:
3141:
3117:
3092:
2929:
2904:
2880:
2855:
2736:
2711:
2561:
Micheli L, Leonardi L, Conti F, Buanne P, Canu N, Caruso M, et al. (March 2005).
2150:
2133:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
739:
734:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
8081:
8072:
7709:
6657:
5398:
5393:
3769:
3760:
3729:
3694:
3653:
3604:
3600:
3568:
3511:
3470:
3435:
3394:
3353:
3312:
3258:
3215:
3163:
3122:
3073:
3032:
2983:
2934:
2885:
2833:
2828:
2819:
2803:
2776:
2772:
2741:
2692:
2643:
2592:
2543:
2492:
2443:
2402:
2351:
2302:
2261:
2212:
2155:
2114:
2065:
2038:
1995:
1934:
1930:
1877:
1873:
1357:
106:
54:
3616:
3523:
2788:
2578:
2230:
Singh K, Cassano M, Planet E, Sebastian S, Jang SM, Sohi G, et al. (Mar 2015).
2167:
1946:
1889:
6608:
6590:
5159:
5106:
4880:
3721:
3684:
3643:
3596:
3558:
3550:
3501:
3462:
3425:
3384:
3343:
3332:"Detection and modulation in vivo of helix-loop-helix protein-protein interactions"
3302:
3270:
3250:
3205:
3197:
3153:
3112:
3104:
3063:
3022:
3014:
2973:
2965:
2924:
2916:
2875:
2867:
2823:
2815:
2768:
2731:
2723:
2682:
2674:
2633:
2623:
2582:
2574:
2533:
2523:
2482:
2474:
2433:
2392:
2382:
2341:
2333:
2292:
2251:
2243:
2202:
2194:
2145:
2104:
2096:
2030:
1985:
1977:
1926:
1869:
403:
334:
278:
233:
1453:. KAP1 is localized at muscle-related genes in myoblasts along with both MyoD and
138:
8749:
7972:
7842:
7006:
2678:
2297:
2281:"Gene regulatory networks and transcriptional mechanisms that control myogenesis"
2280:
2198:
1450:
1340:
378:
162:
2337:
1981:
1819:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1801:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1615:
initiate recruitment of RNA Polymerase II and initiate active RNA transcription.
8846:
7126:
7109:
5252:
4907:
3904:
2969:
614:
RNA polymerase II transcription regulatory region sequence-specific DNA binding
479:
3466:
3201:
2100:
1485:
561:
9289:
7704:
7044:
5469:
5257:
4585:
3490:"I-mf, a novel myogenic repressor, interacts with members of the MyoD family"
3307:
3290:
3018:
2528:
2438:
2421:
1961:
1441:. MyoD is known to have binding interactions with hundreds of muscular gene
1389:
1373:
590:
2804:"Interaction between acetylated MyoD and the bromodomain of CBP and/or p300"
2628:
2387:
2034:
539:
417:
9254:
8566:
8449:
8441:
7812:
7768:
6771:
6619:
3698:
3689:
3672:
3648:
3631:
3474:
3439:
3430:
3413:
3389:
3372:
3262:
3219:
3167:
3108:
3077:
3068:
3051:
3036:
2987:
2837:
2696:
2647:
2596:
2547:
2496:
2447:
2406:
2355:
2306:
2265:
2247:
2216:
2118:
1999:
1592:
from MEF2C); moreover IFRD1 also represses the transcriptional activity of
1333:
396:
175:
3733:
3657:
3608:
3572:
3515:
3398:
3357:
3316:
3126:
2938:
2920:
2905:"Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD"
2889:
2871:
2780:
2745:
2727:
2159:
2069:
2042:
1938:
1881:
1277:
1272:
668:
8938:
8541:
7021:
6736:
6701:
5090:
4895:
4890:
4333:
4137:
4132:
4028:
3908:
3554:
1832:
1400:
1120:
1101:
37:
3254:
2478:
624:
DNA-binding transcription activator activity, RNA polymerase II-specific
9250:
9201:
8673:
8277:
8186:
8166:
8139:
7486:
7235:
7084:
7072:
7067:
6066:
6061:
4825:
4820:
4798:
4664:
4482:
4186:
4127:
4122:
4102:
3412:
McLoughlin P, Ehler E, Carlile G, Licht JD, Schäfer BW (October 2002).
1710:
1396:
1361:
1344:
1301:
295:
192:
142:
3725:
83:
9124:
9114:
9097:
8571:
8344:
7590:
5295:
4724:
4382:
3871:
1506:
1434:
1365:
975:
689:
DNA-binding transcription factor activity, RNA polymerase II-specific
644:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
362:
349:
261:
248:
150:
2419:
8591:
6731:
5290:
5247:
4299:
1610:
1555:
1446:
1408:
1385:
1325:
1261:
8369:
3536:
3330:
Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF (January 1993).
3184:
Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML (April 2001).
1593:
1392:
levels are also reported to be elevated in aging skeletal muscle.
8991:
8971:
8966:
8678:
6652:
6436:
4348:
4343:
4338:
4326:
4321:
3774:
3764:
1629:
1625:
1621:
1297:
1087:
1042:
960:
956:
3049:
2801:
876:
myotube differentiation involved in skeletal muscle regeneration
130:
9172:
9167:
9162:
9152:
9147:
8866:
8421:
8416:
8411:
8406:
7672:
7667:
7544:
7539:
7534:
7519:
7510:
7505:
7500:
7479:
7393:
7388:
7176:
7171:
7151:
7146:
7136:
7131:
6969:
6921:
6916:
6911:
6906:
6876:
6871:
6866:
6861:
6831:
6781:
6776:
6539:
6459:
6431:
6426:
6421:
6416:
6411:
6406:
6401:
6396:
6391:
6386:
6381:
6376:
6371:
6366:
6361:
6356:
6351:
6346:
6336:
6331:
6326:
6321:
6316:
6311:
6306:
6296:
6291:
6286:
6246:
6199:
6194:
6189:
6184:
6179:
6174:
6164:
6152:
6147:
5913:
5908:
5903:
5785:
5780:
5752:
5747:
5732:
5727:
5722:
5712:
5707:
5695:
5690:
5062:
5057:
5052:
5047:
5042:
5017:
4944:
4912:
4855:
4850:
4637:
4632:
4627:
4511:
4316:
4206:
4201:
4174:
4169:
4164:
4090:
2461:
Pan YC, Wang XW, Teng HF, Wu YJ, Chang HC, Chen SL (Feb 2015).
1916:
1599:
1502:
1478:
1245:
997:
946:
positive regulation of snRNA transcription by RNA polymerase II
570:
3780:
3371:
Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998).
117:, MYF3, MYOD, PUM, bHLHc1, myogenic differentiation 1, MYODRIF
9216:
9194:
9189:
9157:
9046:
9041:
8986:
8981:
8976:
8920:
8829:
8824:
8819:
8814:
8809:
8804:
8799:
8794:
8742:
8737:
8725:
8720:
8715:
8710:
8698:
8693:
8688:
8683:
8652:
8619:
8614:
8609:
8556:
8551:
8546:
8521:
8479:
8474:
8469:
8464:
8459:
8454:
8426:
8379:
8374:
8320:
8315:
8310:
8305:
8282:
8057:
8042:
8037:
8032:
8027:
8022:
8017:
8012:
8007:
8002:
7992:
7982:
7977:
7962:
7957:
7947:
7942:
7937:
7927:
7922:
7917:
7912:
7907:
7902:
7897:
7867:
7862:
7852:
7847:
7832:
7827:
7822:
7817:
7751:
7746:
7741:
7714:
7689:
7657:
7650:
7645:
7551:
7529:
7524:
7496:
7474:
7469:
7464:
7459:
7354:
7349:
7294:
7287:
7282:
7267:
7240:
6901:
6896:
6891:
6886:
6881:
6856:
6851:
6846:
6841:
6836:
6826:
6821:
6816:
6811:
6806:
6801:
6796:
6791:
6786:
6766:
6761:
6756:
6751:
6746:
6741:
6726:
6721:
6546:
6534:
6529:
6524:
6519:
6487:
6482:
6281:
6271:
6266:
6261:
6256:
6251:
6241:
6236:
6231:
6226:
6142:
6132:
6125:
6120:
6115:
6110:
6100:
6044:
6039:
6034:
6029:
6024:
6019:
6014:
5935:
5930:
5925:
5869:
5864:
5763:
5742:
5737:
5611:
5606:
5601:
5596:
5591:
5586:
4793:
4558:
4553:
4548:
4538:
4533:
4528:
4518:
4506:
4456:
4436:
4377:
4365:
4360:
4284:
4277:
4272:
4262:
4255:
4250:
4181:
4112:
4085:
4080:
4063:
4058:
4053:
4048:
4043:
4033:
4021:
4016:
3994:
3984:
3979:
3969:
2758:
1727:
1686:
1680:
1662:
1650:
1589:
1585:
1581:
1566:
1562:
1551:
1539:
1438:
20:
3759:
Overview of all the structural information available in the
3629:
3585:
3488:
Chen CM, Kraut N, Groudine M, Weintraub H (September 1996).
2854:
Sartorelli V, Huang J, Hamamori Y, Kedes L (February 1997).
2853:
2710:
Sartorelli V, Huang J, Hamamori Y, Kedes L (February 1997).
2709:
1493:
MyoD has also been shown to function cooperatively with the
1395:
One of the main actions of MyoD is to remove cells from the
9243:
9238:
9233:
9223:
9211:
9206:
9053:
9036:
8900:
8895:
8890:
8861:
8856:
8789:
8784:
8779:
8774:
8769:
8764:
8759:
8754:
8705:
8599:
8561:
8536:
8531:
8526:
8509:
8401:
8394:
8389:
8270:
8265:
8260:
8255:
8250:
8245:
8240:
8235:
8225:
8218:
8208:
8203:
8191:
8181:
8176:
8159:
8154:
8149:
8132:
8127:
8122:
8097:
8092:
8087:
7805:
7800:
7795:
7790:
7785:
7724:
7699:
7694:
7635:
7630:
7625:
7620:
7615:
7610:
7605:
7600:
7595:
7566:
7561:
7454:
7449:
7444:
7439:
7425:
7420:
7415:
7410:
7405:
7376:
7371:
7366:
7332:
7327:
7322:
7317:
7312:
7307:
7272:
7260:
7255:
7250:
7203:
7198:
7193:
7188:
7183:
7104:
7089:
7079:
7055:
7050:
7036:
7031:
7026:
7016:
7011:
6999:
6994:
6938:
6933:
6711:
6696:
6691:
6679:
6674:
6507:
6502:
6497:
6341:
6276:
6221:
6216:
6211:
6095:
6090:
6085:
6009:
6004:
5999:
5994:
5989:
5984:
5979:
5974:
5969:
5952:
5947:
5891:
5886:
5854:
5849:
5844:
5834:
5829:
5822:
5817:
5812:
5807:
5797:
5792:
5775:
5633:
5628:
5623:
5551:
5012:
5007:
5002:
4997:
4992:
4987:
4900:
4885:
4862:
4835:
4808:
4803:
4768:
4746:
4741:
4736:
4719:
4714:
4704:
4694:
4644:
4602:
4597:
4580:
4575:
4570:
4468:
4463:
4451:
4409:
4404:
4394:
4309:
4304:
4213:
4196:
4159:
4147:
4142:
4117:
4075:
4004:
3999:
3974:
3957:
3952:
3947:
3942:
3937:
3927:
3411:
3288:
2609:
2420:
Milewska M, Grabiec K, Grzelkowska-Kowalczyk K (May 2014).
2229:
1733:
1704:
1570:
1535:
1527:
1523:
1462:
1454:
1369:
1329:
1321:
1313:
3670:
3487:
3289:
Langlands K, Yin X, Anand G, Prochownik EV (August 1997).
2560:
1959:
891:
positive regulation of skeletal muscle tissue regeneration
8885:
8514:
8504:
8384:
7780:
7337:
6686:
6137:
5874:
5368:
4840:
4669:
4659:
4654:
4446:
4441:
3232:
2131:
1698:
1692:
1466:
1404:
926:
positive regulation of transcription by RNA polymerase II
3183:
2903:
Kong Y, Flick MJ, Kudla AJ, Konieczny SF (August 1997).
2012:
1437:
remodelling through binding to a DNA motif known as the
811:
positive regulation of skeletal muscle fiber development
801:
regulation of alternative mRNA splicing, via spliceosome
386:
5086:
2902:
3091:
Lau P, Bailey P, Dowhan DH, Muscat GE (January 1999).
3052:"Stabilization of MyoD by direct binding to p57(Kip2)"
3001:
Zhang JM, Wei Q, Zhao X, Paterson BM (February 1999).
2952:
Zhang JM, Zhao X, Wei Q, Paterson BM (December 1999).
2512:"Muscle satellite cell heterogeneity and self-renewal"
2132:
Hughes SM, Koishi K, Rudnicki M, Maggs AM (Jan 1997).
2055:
3139:
3090:
1477:
Once the "master controller" MyoD has become active,
551:
3000:
2951:
1859:
1596:, which is known to inhibit MyoD mRNA accumulation.
1465:, in addition to several corepressors which include
9015:
3711:
3329:
2368:
1960:Hinits Y, Williams VC, Sweetman D, Donn TM, Ma TP,
831:
positive regulation of transcription, DNA-templated
3370:
1775:
1773:
1771:
1754:
1752:
1750:
1304:. MyoD, which was discovered in the laboratory of
936:positive regulation of muscle cell differentiation
2660:
2180:
1517:
1411:. MyoD is inhibited by cyclin dependent kinases (
1384:The function of MyoD in development is to commit
1300:in animals that plays a major role in regulating
333:
232:
9287:
6586:
3773:(Mouse Myoblast determination protein 1) at the
3452:
2509:
2085:"Skeletal muscle programming and re-programming"
771:regulation of transcription by RNA polymerase II
3179:
3177:
2278:
1904:"Entrez Gene: MYOD1 myogenic differentiation 1"
1768:
1747:
861:positive regulation of myoblast differentiation
3284:
3282:
3280:
2849:
2847:
1780:GRCm38: Ensembl release 89: ENSMUSG00000009471
1576:
9276:transcription factor/coregulator deficiencies
8347:β-Scaffold factors with minor groove contacts
3857:
3796:
2460:
2089:Current Opinion in Genetics & Development
816:negative regulation of myoblast proliferation
3664:
3446:
3405:
3226:
3174:
3133:
3043:
2994:
2945:
2795:
2603:
2554:
2369:Rajabi HN, Takahashi C, Ewen ME (Aug 2014).
2082:
1855:
1853:
1336:, a single MyoD protein is typically found.
856:cellular response to glucocorticoid stimulus
3705:
3623:
3579:
3530:
3481:
3364:
3323:
3277:
3084:
2896:
2844:
2752:
2516:Frontiers in Cell and Developmental Biology
2319:
1759:GRCh38: Ensembl release 89: ENSG00000129152
1308:, belongs to a family of proteins known as
3864:
3850:
3803:
3789:
2661:Ehlers ML, Celona B, Black BL (Sep 2014).
2181:Ehlers ML, Celona B, Black BL (Sep 2014).
941:cellular response to tumor necrosis factor
766:regulation of transcription, DNA-templated
444:Skeletal muscle tissue of rectus abdominis
3752:at the U.S. National Library of Medicine
3688:
3647:
3562:
3505:
3429:
3388:
3347:
3306:
3209:
3157:
3116:
3067:
3026:
2977:
2928:
2879:
2827:
2735:
2686:
2637:
2627:
2586:
2537:
2527:
2486:
2437:
2426:Postepy Higieny I Medycyny Doswiadczalnej
2396:
2386:
2345:
2296:
2255:
2206:
2149:
2108:
1989:
1850:
1550:. Wnt1 from dorsal neural tube and Wnt6/
629:DNA-binding transcription factor activity
2279:Buckingham M, Rigby PW (February 2014).
1609:
1546:interactions with a distal enhancer and
1542:can directly induce MyoD expression via
1484:
432:Skeletal muscle tissue of biceps brachii
2510:Motohashi N, Asakura A (January 2014).
786:cellular response to estradiol stimulus
16:Mammalian protein found in Homo sapiens
9288:
846:positive regulation of myoblast fusion
9014:
8343:
6585:
5085:
3888:
3887:
3845:
3784:
2083:Fong AP, Tapscott SJ (October 2013).
338:
299:
294:
237:
196:
191:
2320:Song YJ, Choi JH, Lee H (Feb 2015).
1675:Cyclin-dependent kinase inhibitor 1C
901:striated muscle cell differentiation
886:skeletal muscle cell differentiation
5030:(1.6) Basic helix-span-helix (bHSH)
2375:The Journal of Biological Chemistry
694:promoter-specific chromatin binding
659:protein heterodimerization activity
13:
931:transcription by RNA polymerase II
921:skeletal muscle tissue development
906:cellular response to oxygen levels
826:multicellular organism development
684:transcription coactivator activity
14:
9317:
3743:
866:skeletal muscle fiber development
3821:
2820:10.1128/MCB.21.16.5312-5320.2001
1294:myoblast determination protein 1
791:skeletal muscle fiber adaptation
679:ubiquitin protein ligase binding
560:
526:extensor digitorum longus muscle
322:
315:
309:
286:
221:
214:
208:
183:
36:
9017:(0) Other transcription factors
8301:transcriptional enhancer factor
3918:Activating transcription factor
3810:
2703:
2654:
2579:10.1128/MCB.25.6.2242-2259.2005
2503:
2454:
2413:
2362:
2313:
2272:
2223:
2174:
2125:
2076:
2049:
2006:
1636:
776:cellular response to starvation
710:transcription regulator complex
2716:Molecular and Cellular Biology
1953:
1910:
1896:
1825:
1807:
1789:
1518:Wnt signalling can affect MyoD
571:More reference expression data
540:More reference expression data
1:
8231:Interferon regulatory factors
6470:(2.5) Alternating composition
5666:General transcription factors
3507:10.1016/s0092-8674(00)80148-8
3349:10.1016/S0021-9258(18)54105-3
3159:10.1016/s1097-2765(01)00373-2
2151:10.1016/S0925-4773(96)00631-4
1741:
1424:
896:regulation of gene expression
619:protein dimerization activity
609:sequence-specific DNA binding
307:
206:
9296:Genes on human chromosome 11
7516:Octamer transcription factor
4224:(1.2) Basic helix-loop-helix
3601:10.1016/0092-8674(93)90110-c
2773:10.1016/0092-8674(92)90187-h
2679:10.1016/j.celrep.2014.08.035
2298:10.1016/j.devcel.2013.12.020
2199:10.1016/j.celrep.2014.08.035
1931:10.1016/0092-8674(93)90621-V
1874:10.1016/0092-8674(87)90585-X
821:transcription, DNA-templated
634:transcription factor binding
7:
4290:Myogenic regulatory factors
2338:10.14348/molcells.2015.2291
2058:Princess Takamatsu Symposia
1982:10.1016/j.ydbio.2011.07.015
1577:Coactivators and repressors
1532:myogenic regulatory factors
1379:
1310:myogenic regulatory factors
851:myoblast fate determination
781:muscle cell fate commitment
10:
9322:
1964:, et al. (Oct 2011).
1350:
841:regulation of RNA splicing
510:sternocleidomastoid muscle
18:
9271:
9133:
9093:
9062:
9027:
9023:
9010:
8952:
8929:
8911:
8661:
8635:
8587:
8490:
8437:
8357:
8353:
8339:
8291:
8110:(3.5) Tryptophan clusters
8108:
8068:
7764:
7581:
7221:
6947:
6635:
6616:
6604:
6600:
6581:
6555:
6468:
6447:
5649:
5569:
5540:
5520:
5495:
5458:
5377:
5273:
5121:
5102:
5098:
5081:
5028:
4973:
4871:
4781:
4757:
4680:
4613:
4477:
4427:
4236:
4222:
3900:
3896:
3883:
3816:
3467:10.1016/j.jmb.2007.06.020
2101:10.1016/j.gde.2013.05.002
1815:"Mouse PubMed Reference:"
1797:"Human PubMed Reference:"
1723:Retinoid X receptor alpha
1669:Cyclin-dependent kinase 4
1316:(basic helix loop helix)
1276:
1271:
1267:
1260:
1244:
1225:
1210:
1206:
1189:
1185:
1178:
1163:
1159:
1142:
1138:
1131:
1118:
1114:
1099:
1095:
1086:
1073:
1069:
1054:
1050:
1041:
1028:
1024:
1009:
1005:
996:
981:
974:
970:
954:
589:
585:
568:
559:
550:
537:
486:
477:
424:
415:
385:
377:
373:
356:
343:
306:
285:
276:
272:
255:
242:
205:
182:
173:
169:
124:
121:
111:
104:
99:
80:
75:
58:
53:
48:
44:
35:
30:
8931:(4.10) Cold-shock domain
3754:Medical Subject Headings
3308:10.1074/jbc.272.32.19785
2970:10.1093/emboj/18.24.6983
2529:10.3389/fcell.2014.00001
2439:10.5604/17322693.1101617
1538:and MyoD. Specifically,
1231:Chr 11: 17.72 – 17.72 Mb
916:myoblast differentiation
806:myotube cell development
796:muscle organ development
19:Not to be confused with
3877:intracellular receptors
3202:10.1093/emboj/20.7.1739
2629:10.1074/jbc.M110.162842
2388:10.1074/jbc.M113.532572
2236:Genes & Development
2035:10.1126/science.3175662
1641:MyoD has been shown to
1238:Chr 7: 46.03 – 46.03 Mb
836:protein phosphorylation
761:myotube differentiation
440:vastus lateralis muscle
3690:10.1074/jbc.M304884200
3649:10.1038/sj.onc.1201894
3431:10.1074/jbc.M203336200
3390:10.1038/sj.onc.1201634
3069:10.1074/jbc.M907412199
3019:10.1093/emboj/18.4.926
2248:10.1101/gad.254532.114
1833:"P15172 (MYOD1_HUMAN)"
1717:Retinoblastoma protein
1616:
1490:
1370:basic helix loop helix
1334:non-vertebrate animals
1302:muscle differentiation
881:histone H4 acetylation
871:histone H3 acetylation
518:skeletal muscle tissue
506:triceps brachii muscle
428:triceps brachii muscle
9301:Transcription factors
8640:TATA-binding proteins
3873:Transcription factors
2921:10.1128/mcb.17.8.4750
2872:10.1128/mcb.17.2.1010
2728:10.1128/mcb.17.2.1010
1613:
1495:tumor suppressor gene
1488:
1318:transcription factors
674:chromatin DNA binding
199:Chromosome 11 (human)
3555:10.1128/mcb.17.2.584
3109:10.1093/nar/27.2.411
1657:CREB-binding protein
1548:Wnt response element
1433:and can also direct
1431:transcription factor
756:cell differentiation
452:gastrocnemius muscle
340:7 B3|7 30.03 cM
301:Chromosome 7 (mouse)
76:List of PDB id codes
49:Available structures
9135:(0.6) Miscellaneous
8666:High-mobility group
8362:Rel homology region
5352:Testicular receptor
5093:DNA-binding domains
3255:10.1038/nature02329
3247:2004Natur.428..328G
2479:10.1042/BSR20140177
2381:(34): 23417–23427.
2326:Molecules and Cells
2027:1988Sci...242..405T
1471:Histone deacetylase
1306:Harold M. Weintraub
8500:p53 p63 p73 family
8073:Heat shock factors
2467:Bioscience Reports
2285:Developmental Cell
1617:
1491:
1076:ENSMUSG00000009471
749:Biological process
703:Cellular component
597:Molecular function
9283:
9282:
9267:
9266:
9263:
9262:
9006:
9005:
9002:
9001:
8335:
8334:
8331:
8330:
7577:
7576:
7217:
7216:
6577:
6576:
6573:
6572:
5565:
5564:
5421:Mineralocorticoid
5077:
5076:
5073:
5072:
4777:
4776:
3890:(1) Basic domains
3839:
3838:
3726:10.1021/bi970262m
3097:Nucleic Acids Res
2021:(4877): 405–511.
1287:
1286:
1283:
1282:
1256:
1255:
1221:
1220:
1200:
1199:
1174:
1173:
1153:
1152:
1127:
1126:
1108:
1107:
1082:
1081:
1063:
1062:
1037:
1036:
1018:
1017:
966:
965:
639:chromatin binding
581:
580:
577:
576:
546:
545:
533:
532:
471:
470:
369:
368:
268:
267:
163:MYOD1 - orthologs
95:
94:
91:
90:
59:Ortholog search:
9313:
9107:-related factors
9025:
9024:
9012:
9011:
8913:(4.9) Grainyhead
8355:
8354:
8341:
8340:
8293:(3.6) TEA domain
7583:(3.2) Paired box
7224:
6958:
6952:
6646:
6640:
6633:
6632:
6629:
6623:
6614:
6613:
6602:
6601:
6591:Helix-turn-helix
6583:
6582:
5545:
5525:
5500:
5463:
5433:Estrogen related
5382:
5278:
5126:
5119:
5118:
5107:Nuclear receptor
5100:
5099:
5083:
5082:
4762:
4683:
4616:
4485:
4430:
4239:
4234:
4233:
3898:
3897:
3885:
3884:
3866:
3859:
3852:
3843:
3842:
3825:
3805:
3798:
3791:
3782:
3781:
3738:
3737:
3709:
3703:
3702:
3692:
3683:(45): 44178–87.
3668:
3662:
3661:
3651:
3627:
3621:
3620:
3583:
3577:
3576:
3566:
3534:
3528:
3527:
3509:
3485:
3479:
3478:
3450:
3444:
3443:
3433:
3424:(40): 37045–53.
3409:
3403:
3402:
3392:
3368:
3362:
3361:
3351:
3327:
3321:
3320:
3310:
3301:(32): 19785–93.
3286:
3275:
3274:
3241:(6980): 328–32.
3230:
3224:
3223:
3213:
3181:
3172:
3171:
3161:
3137:
3131:
3130:
3120:
3088:
3082:
3081:
3071:
3062:(25): 18767–76.
3047:
3041:
3040:
3030:
2998:
2992:
2991:
2981:
2949:
2943:
2942:
2932:
2900:
2894:
2893:
2883:
2851:
2842:
2841:
2831:
2799:
2793:
2792:
2756:
2750:
2749:
2739:
2722:(2): 1010–1026.
2707:
2701:
2700:
2690:
2673:(6): 1639–1648.
2658:
2652:
2651:
2641:
2631:
2607:
2601:
2600:
2590:
2558:
2552:
2551:
2541:
2531:
2507:
2501:
2500:
2490:
2458:
2452:
2451:
2441:
2417:
2411:
2410:
2400:
2390:
2366:
2360:
2359:
2349:
2317:
2311:
2310:
2300:
2276:
2270:
2269:
2259:
2227:
2221:
2220:
2210:
2193:(6): 1639–1648.
2178:
2172:
2171:
2153:
2144:(1–2): 151–163.
2129:
2123:
2122:
2112:
2080:
2074:
2073:
2053:
2047:
2046:
2010:
2004:
2003:
1993:
1957:
1951:
1950:
1925:(7): 1351–1359.
1914:
1908:
1907:
1900:
1894:
1893:
1857:
1848:
1847:
1845:
1843:
1829:
1823:
1822:
1811:
1805:
1804:
1793:
1787:
1777:
1766:
1756:
1292:, also known as
1269:
1268:
1240:
1233:
1216:
1204:
1203:
1195:
1183:
1182:
1179:RefSeq (protein)
1169:
1157:
1156:
1148:
1136:
1135:
1112:
1111:
1093:
1092:
1067:
1066:
1048:
1047:
1022:
1021:
1003:
1002:
972:
971:
587:
586:
573:
564:
557:
556:
542:
482:
480:Top expressed in
475:
474:
420:
418:Top expressed in
413:
412:
392:
391:
375:
374:
365:
352:
341:
326:
319:
313:
302:
290:
274:
273:
264:
251:
240:
225:
218:
212:
201:
187:
171:
170:
165:
116:
109:
86:
73:
72:
67:
46:
45:
40:
28:
27:
9321:
9320:
9316:
9315:
9314:
9312:
9311:
9310:
9286:
9285:
9284:
9279:
9259:
9129:
9089:
9058:
9019:
8998:
8948:
8925:
8907:
8657:
8631:
8583:
8486:
8433:
8349:
8327:
8287:
8104:
8064:
7760:
7573:
7222:
7213:
6954:
6953:
6948:
6943:
6642:
6641:
6636:
6625:
6624:
6617:
6596:
6569:
6551:
6464:
6452:
6443:
5658:
5654:
5645:
5574:
5571:(2.2) Other Cys
5561:
5541:
5536:
5521:
5516:
5496:
5491:
5459:
5454:
5389:Steroid hormone
5378:
5373:
5274:
5269:
5133:Thyroid hormone
5122:
5113:
5094:
5069:
5024:
4969:
4867:
4773:
4760:
4758:
4753:
4681:
4676:
4614:
4609:
4480:
4478:
4473:
4428:
4423:
4237:
4218:
3892:
3879:
3870:
3840:
3835:
3832:
3826:
3812:
3809:
3746:
3741:
3710:
3706:
3669:
3665:
3642:(26): 3369–78.
3628:
3624:
3584:
3580:
3543:Mol. Cell. Biol
3535:
3531:
3486:
3482:
3451:
3447:
3410:
3406:
3369:
3365:
3328:
3324:
3287:
3278:
3231:
3227:
3182:
3175:
3138:
3134:
3089:
3085:
3048:
3044:
2999:
2995:
2964:(24): 6983–93.
2950:
2946:
2909:Mol. Cell. Biol
2901:
2897:
2860:Mol. Cell. Biol
2852:
2845:
2814:(16): 5312–20.
2808:Mol. Cell. Biol
2800:
2796:
2757:
2753:
2708:
2704:
2659:
2655:
2622:(7): 5691–707.
2608:
2604:
2567:Mol. Cell. Biol
2559:
2555:
2508:
2504:
2459:
2455:
2418:
2414:
2367:
2363:
2318:
2314:
2277:
2273:
2228:
2224:
2179:
2175:
2130:
2126:
2081:
2077:
2054:
2050:
2011:
2007:
1958:
1954:
1915:
1911:
1902:
1901:
1897:
1868:(6): 987–1000.
1858:
1851:
1841:
1839:
1831:
1830:
1826:
1813:
1812:
1808:
1795:
1794:
1790:
1778:
1769:
1757:
1748:
1744:
1739:
1639:
1588:(by displacing
1579:
1530:in addition to
1520:
1451:phosphorylation
1427:
1382:
1353:
1341:satellite cells
1278:View/Edit Mouse
1273:View/Edit Human
1236:
1229:
1226:Location (UCSC)
1212:
1191:
1165:
1144:
1057:ENSG00000129152
950:
911:myoblast fusion
744:
698:
654:protein binding
569:
538:
529:
524:
520:
516:
514:temporal muscle
512:
508:
504:
502:muscle of thigh
500:
496:
492:
478:
467:
462:
458:
454:
450:
448:muscle of thigh
446:
442:
438:
434:
430:
416:
360:
347:
339:
329:
328:
327:
320:
300:
277:Gene location (
259:
246:
238:
228:
227:
226:
219:
197:
174:Gene location (
125:
112:
105:
82:
60:
24:
17:
12:
11:
5:
9319:
9309:
9308:
9306:Human proteins
9303:
9298:
9281:
9280:
9272:
9269:
9268:
9265:
9264:
9261:
9260:
9258:
9257:
9248:
9247:
9246:
9241:
9236:
9226:
9221:
9220:
9219:
9214:
9209:
9199:
9198:
9197:
9192:
9182:
9177:
9176:
9175:
9170:
9165:
9160:
9155:
9150:
9139:
9137:
9131:
9130:
9128:
9127:
9122:
9117:
9111:
9109:
9091:
9090:
9088:
9087:
9082:
9077:
9071:
9069:
9060:
9059:
9057:
9056:
9051:
9050:
9049:
9044:
9033:
9031:
9021:
9020:
9008:
9007:
9004:
9003:
9000:
8999:
8997:
8996:
8995:
8994:
8989:
8984:
8979:
8974:
8969:
8958:
8956:
8950:
8949:
8947:
8946:
8941:
8935:
8933:
8927:
8926:
8924:
8923:
8917:
8915:
8909:
8908:
8906:
8905:
8904:
8903:
8898:
8893:
8888:
8878:
8877:
8876:
8871:
8870:
8869:
8864:
8859:
8844:
8839:
8834:
8833:
8832:
8827:
8822:
8817:
8812:
8807:
8802:
8797:
8792:
8787:
8782:
8777:
8772:
8767:
8762:
8757:
8747:
8746:
8745:
8740:
8730:
8729:
8728:
8723:
8718:
8713:
8703:
8702:
8701:
8696:
8691:
8686:
8676:
8670:
8668:
8659:
8658:
8656:
8655:
8650:
8644:
8642:
8633:
8632:
8630:
8629:
8624:
8623:
8622:
8617:
8612:
8607:
8596:
8594:
8585:
8584:
8582:
8581:
8576:
8575:
8574:
8569:
8564:
8559:
8554:
8549:
8544:
8539:
8534:
8529:
8519:
8518:
8517:
8512:
8507:
8496:
8494:
8492:(4.3) p53-like
8488:
8487:
8485:
8484:
8483:
8482:
8477:
8472:
8467:
8462:
8457:
8446:
8444:
8435:
8434:
8432:
8431:
8430:
8429:
8424:
8419:
8414:
8409:
8399:
8398:
8397:
8392:
8387:
8382:
8377:
8366:
8364:
8351:
8350:
8337:
8336:
8333:
8332:
8329:
8328:
8326:
8325:
8324:
8323:
8318:
8313:
8308:
8297:
8295:
8289:
8288:
8286:
8285:
8280:
8275:
8274:
8273:
8268:
8263:
8258:
8253:
8248:
8243:
8238:
8228:
8223:
8222:
8221:
8216:
8211:
8206:
8196:
8195:
8194:
8189:
8184:
8179:
8169:
8164:
8163:
8162:
8157:
8152:
8142:
8137:
8136:
8135:
8130:
8125:
8114:
8112:
8106:
8105:
8103:
8102:
8101:
8100:
8095:
8090:
8077:
8075:
8066:
8065:
8063:
8062:
8061:
8060:
8055:
8050:
8045:
8040:
8035:
8030:
8025:
8020:
8015:
8010:
8005:
8000:
7995:
7990:
7985:
7980:
7975:
7970:
7965:
7960:
7955:
7950:
7945:
7940:
7935:
7930:
7925:
7920:
7915:
7910:
7905:
7900:
7895:
7890:
7885:
7880:
7875:
7870:
7865:
7860:
7855:
7850:
7845:
7840:
7835:
7830:
7825:
7820:
7810:
7809:
7808:
7803:
7798:
7793:
7788:
7777:
7775:
7762:
7761:
7759:
7758:
7757:
7756:
7755:
7754:
7749:
7744:
7734:
7733:
7732:
7727:
7717:
7712:
7702:
7697:
7692:
7687:
7682:
7677:
7676:
7675:
7670:
7660:
7655:
7654:
7653:
7648:
7640:
7639:
7638:
7633:
7628:
7623:
7618:
7613:
7608:
7603:
7598:
7587:
7585:
7579:
7578:
7575:
7574:
7572:
7571:
7570:
7569:
7564:
7554:
7549:
7548:
7547:
7542:
7537:
7532:
7527:
7522:
7513:
7508:
7503:
7494:
7484:
7483:
7482:
7477:
7472:
7467:
7462:
7457:
7452:
7447:
7442:
7432:
7431:
7430:
7429:
7428:
7423:
7418:
7413:
7408:
7398:
7397:
7396:
7391:
7381:
7380:
7379:
7374:
7369:
7359:
7358:
7357:
7352:
7342:
7341:
7340:
7335:
7330:
7325:
7320:
7315:
7310:
7297:
7292:
7291:
7290:
7285:
7275:
7270:
7265:
7264:
7263:
7258:
7253:
7243:
7238:
7233:
7227:
7225:
7219:
7218:
7215:
7214:
7212:
7211:
7206:
7201:
7196:
7191:
7186:
7181:
7180:
7179:
7174:
7169:
7164:
7159:
7154:
7149:
7144:
7139:
7134:
7129:
7119:
7114:
7113:
7112:
7107:
7097:
7092:
7087:
7082:
7077:
7076:
7075:
7070:
7060:
7059:
7058:
7053:
7041:
7040:
7039:
7034:
7029:
7024:
7019:
7014:
7004:
7003:
7002:
6997:
6987:
6982:
6977:
6972:
6967:
6961:
6959:
6945:
6944:
6942:
6941:
6936:
6931:
6926:
6925:
6924:
6919:
6914:
6909:
6904:
6899:
6894:
6889:
6884:
6879:
6874:
6869:
6864:
6859:
6854:
6849:
6844:
6839:
6834:
6829:
6824:
6819:
6814:
6809:
6804:
6799:
6794:
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6729:
6724:
6719:
6714:
6710:extended Hox:
6708:
6707:
6706:
6705:
6704:
6699:
6694:
6684:
6683:
6682:
6672:
6671:
6670:
6665:
6649:
6647:
6630:
6611:
6598:
6597:
6579:
6578:
6575:
6574:
6571:
6570:
6568:
6567:
6561:
6559:
6553:
6552:
6550:
6549:
6544:
6543:
6542:
6537:
6532:
6527:
6522:
6512:
6511:
6510:
6505:
6500:
6490:
6485:
6480:
6474:
6472:
6466:
6465:
6463:
6462:
6456:
6454:
6450:
6445:
6444:
6442:
6441:
6440:
6439:
6434:
6429:
6424:
6419:
6414:
6409:
6404:
6399:
6394:
6389:
6384:
6379:
6374:
6369:
6364:
6359:
6354:
6349:
6344:
6339:
6334:
6329:
6324:
6319:
6314:
6309:
6304:
6299:
6294:
6289:
6284:
6279:
6274:
6269:
6264:
6259:
6254:
6249:
6244:
6239:
6234:
6229:
6224:
6219:
6214:
6204:
6203:
6202:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6157:
6156:
6155:
6150:
6140:
6135:
6130:
6129:
6128:
6123:
6118:
6113:
6103:
6098:
6093:
6088:
6083:
6082:
6081:
6080:
6079:
6074:
6069:
6064:
6059:
6049:
6048:
6047:
6042:
6037:
6032:
6027:
6022:
6017:
6012:
6007:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5957:
5956:
5955:
5950:
5940:
5939:
5938:
5933:
5928:
5918:
5917:
5916:
5911:
5906:
5896:
5895:
5894:
5889:
5879:
5878:
5877:
5872:
5867:
5862:
5857:
5852:
5847:
5837:
5832:
5827:
5826:
5825:
5820:
5815:
5810:
5800:
5795:
5790:
5789:
5788:
5783:
5778:
5766:
5760:
5759:
5758:
5757:
5756:
5755:
5750:
5745:
5740:
5735:
5730:
5725:
5720:
5710:
5705:
5700:
5699:
5698:
5693:
5683:
5678:
5673:
5662:
5660:
5656:
5652:
5647:
5646:
5644:
5643:
5638:
5637:
5636:
5631:
5626:
5616:
5615:
5614:
5609:
5604:
5599:
5594:
5589:
5578:
5576:
5572:
5567:
5566:
5563:
5562:
5560:
5559:
5554:
5548:
5546:
5538:
5537:
5535:
5534:
5528:
5526:
5518:
5517:
5515:
5514:
5509:
5503:
5501:
5493:
5492:
5490:
5489:
5488:
5487:
5482:
5477:
5466:
5464:
5456:
5455:
5453:
5452:
5451:
5450:
5445:
5440:
5430:
5429:
5428:
5423:
5418:
5416:Glucocorticoid
5413:
5412:
5411:
5406:
5396:
5385:
5383:
5375:
5374:
5372:
5371:
5366:
5365:
5364:
5359:
5349:
5348:
5347:
5342:
5337:
5327:
5322:
5321:
5320:
5315:
5305:
5300:
5299:
5298:
5293:
5281:
5279:
5271:
5270:
5268:
5267:
5262:
5261:
5260:
5255:
5245:
5244:
5243:
5238:
5233:
5223:
5222:
5221:
5216:
5211:
5201:
5196:
5195:
5194:
5189:
5184:
5174:
5173:
5172:
5167:
5157:
5152:
5147:
5146:
5145:
5140:
5129:
5127:
5116:
5111:
5096:
5095:
5079:
5078:
5075:
5074:
5071:
5070:
5068:
5067:
5066:
5065:
5060:
5055:
5050:
5045:
5034:
5032:
5026:
5025:
5023:
5022:
5021:
5020:
5015:
5010:
5005:
5000:
4995:
4990:
4979:
4977:
4971:
4970:
4968:
4967:
4966:
4965:
4959:
4958:
4957:
4952:
4942:
4941:
4940:
4935:
4930:
4925:
4920:
4905:
4904:
4903:
4898:
4893:
4888:
4877:
4875:
4869:
4868:
4866:
4865:
4860:
4859:
4858:
4853:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4812:
4811:
4806:
4796:
4790:
4788:
4779:
4778:
4775:
4774:
4772:
4771:
4765:
4763:
4755:
4754:
4752:
4751:
4750:
4749:
4744:
4739:
4729:
4728:
4727:
4722:
4717:
4712:
4707:
4702:
4697:
4686:
4684:
4678:
4677:
4675:
4674:
4673:
4672:
4667:
4662:
4657:
4647:
4642:
4641:
4640:
4635:
4630:
4619:
4617:
4611:
4610:
4608:
4607:
4606:
4605:
4600:
4590:
4589:
4588:
4583:
4578:
4573:
4563:
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4521:
4516:
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4509:
4499:
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4486:
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4466:
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4460:
4459:
4454:
4449:
4439:
4433:
4431:
4425:
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4422:
4421:
4416:
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4412:
4407:
4397:
4387:
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4385:
4380:
4370:
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4368:
4363:
4353:
4352:
4351:
4346:
4341:
4331:
4330:
4329:
4324:
4314:
4313:
4312:
4307:
4302:
4297:
4287:
4282:
4281:
4280:
4275:
4265:
4260:
4259:
4258:
4253:
4242:
4240:
4231:
4220:
4219:
4217:
4216:
4211:
4210:
4209:
4204:
4199:
4189:
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4179:
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4177:
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4162:
4152:
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4150:
4145:
4140:
4135:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4094:
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4088:
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4073:
4072:
4071:
4066:
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4046:
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4024:
4019:
4009:
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4007:
4002:
3997:
3992:
3987:
3982:
3977:
3972:
3962:
3961:
3960:
3955:
3950:
3945:
3940:
3935:
3930:
3925:
3914:
3912:
3905:leucine zipper
3894:
3893:
3881:
3880:
3869:
3868:
3861:
3854:
3846:
3837:
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3834:
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3827:
3820:
3817:
3814:
3813:
3808:
3807:
3800:
3793:
3785:
3779:
3778:
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3745:
3744:External links
3742:
3740:
3739:
3720:(22): 6762–7.
3704:
3663:
3622:
3578:
3529:
3480:
3445:
3404:
3383:(9): 1149–59.
3363:
3322:
3276:
3225:
3196:(7): 1739–53.
3173:
3132:
3083:
3042:
2993:
2944:
2915:(8): 4750–60.
2895:
2866:(2): 1010–26.
2843:
2794:
2751:
2702:
2653:
2602:
2573:(6): 2242–59.
2553:
2502:
2453:
2412:
2361:
2332:(4): 362–372.
2312:
2291:(3): 225–238.
2271:
2242:(5): 513–525.
2222:
2173:
2124:
2095:(5): 568–573.
2075:
2048:
2005:
1976:(1): 102–112.
1952:
1909:
1895:
1849:
1824:
1806:
1788:
1767:
1745:
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1740:
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1672:
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1660:
1654:
1647:
1638:
1635:
1620:recruit Set7,
1578:
1575:
1519:
1516:
1499:Retinoblastoma
1445:and to permit
1426:
1423:
1381:
1378:
1352:
1349:
1312:(MRFs). These
1285:
1284:
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828:
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717:
712:
706:
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691:
686:
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666:
664:enzyme binding
661:
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636:
631:
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621:
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507:
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487:
484:
483:
472:
469:
468:
466:
465:
461:
460:deltoid muscle
457:
453:
449:
445:
441:
437:
433:
429:
425:
422:
421:
409:
408:
400:
389:
383:
382:
379:RNA expression
371:
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15:
9:
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3:
2:
9318:
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9270:
9256:
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9208:
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9132:
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9112:
9110:
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9105:
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9099:
9096:
9092:
9086:
9083:
9081:
9078:
9076:
9073:
9072:
9070:
9068:
9067:Pocket domain
9065:
9061:
9055:
9052:
9048:
9045:
9043:
9040:
9039:
9038:
9035:
9034:
9032:
9030:
9029:(0.2) HMGI(Y)
9026:
9022:
9018:
9013:
9009:
8993:
8990:
8988:
8985:
8983:
8980:
8978:
8975:
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8360:
8356:
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8312:
8309:
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8299:
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8233:
8232:
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8227:
8224:
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8212:
8210:
8207:
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8119:
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8107:
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8009:
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7861:
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7841:
7839:
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7826:
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7811:
7807:
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7438:
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7409:
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7399:
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7390:
7387:
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7373:
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7364:
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7319:
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7311:
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7300:
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7280:
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7271:
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7234:
7232:
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7018:
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6471:
6467:
6461:
6458:
6457:
6455:
6453:
6446:
6438:
6435:
6433:
6430:
6428:
6425:
6423:
6420:
6418:
6415:
6413:
6410:
6408:
6405:
6403:
6400:
6398:
6395:
6393:
6390:
6388:
6385:
6383:
6380:
6378:
6375:
6373:
6370:
6368:
6365:
6363:
6360:
6358:
6355:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6318:
6315:
6313:
6310:
6308:
6305:
6303:
6300:
6298:
6295:
6293:
6290:
6288:
6285:
6283:
6280:
6278:
6275:
6273:
6270:
6268:
6265:
6263:
6260:
6258:
6255:
6253:
6250:
6248:
6245:
6243:
6240:
6238:
6235:
6233:
6230:
6228:
6225:
6223:
6220:
6218:
6215:
6213:
6210:
6209:
6208:
6205:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:
6162:
6161:
6158:
6154:
6151:
6149:
6146:
6145:
6144:
6141:
6139:
6136:
6134:
6131:
6127:
6124:
6122:
6119:
6117:
6114:
6112:
6109:
6108:
6107:
6104:
6102:
6099:
6097:
6094:
6092:
6089:
6087:
6084:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6054:
6053:
6050:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6028:
6026:
6023:
6021:
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5996:
5993:
5991:
5988:
5986:
5983:
5981:
5978:
5976:
5973:
5971:
5968:
5967:
5966:
5963:
5962:
5961:
5960:Sp/KLF family
5958:
5954:
5951:
5949:
5946:
5945:
5944:
5941:
5937:
5934:
5932:
5929:
5927:
5924:
5923:
5922:
5919:
5915:
5912:
5910:
5907:
5905:
5902:
5901:
5900:
5897:
5893:
5890:
5888:
5885:
5884:
5883:
5880:
5876:
5873:
5871:
5868:
5866:
5863:
5861:
5858:
5856:
5853:
5851:
5848:
5846:
5843:
5842:
5841:
5838:
5836:
5833:
5831:
5828:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5805:
5804:
5801:
5799:
5796:
5794:
5791:
5787:
5784:
5782:
5779:
5777:
5774:
5773:
5772:
5771:
5767:
5765:
5762:
5761:
5754:
5751:
5749:
5746:
5744:
5741:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5719:
5716:
5715:
5714:
5711:
5709:
5706:
5704:
5701:
5697:
5694:
5692:
5689:
5688:
5687:
5684:
5682:
5679:
5677:
5674:
5672:
5669:
5668:
5667:
5664:
5663:
5661:
5659:
5648:
5642:
5639:
5635:
5632:
5630:
5627:
5625:
5622:
5621:
5620:
5617:
5613:
5610:
5608:
5605:
5603:
5600:
5598:
5595:
5593:
5590:
5588:
5585:
5584:
5583:
5580:
5579:
5577:
5575:
5568:
5558:
5555:
5553:
5550:
5549:
5547:
5544:
5539:
5533:
5530:
5529:
5527:
5524:
5519:
5513:
5510:
5508:
5505:
5504:
5502:
5499:
5494:
5486:
5483:
5481:
5478:
5476:
5473:
5472:
5471:
5468:
5467:
5465:
5462:
5457:
5449:
5446:
5444:
5441:
5439:
5436:
5435:
5434:
5431:
5427:
5424:
5422:
5419:
5417:
5414:
5410:
5407:
5405:
5402:
5401:
5400:
5397:
5395:
5392:
5391:
5390:
5387:
5386:
5384:
5381:
5376:
5370:
5367:
5363:
5360:
5358:
5355:
5354:
5353:
5350:
5346:
5343:
5341:
5338:
5336:
5333:
5332:
5331:
5328:
5326:
5323:
5319:
5316:
5314:
5311:
5310:
5309:
5306:
5304:
5301:
5297:
5294:
5292:
5288:
5287:
5286:
5283:
5282:
5280:
5277:
5272:
5266:
5263:
5259:
5256:
5254:
5251:
5250:
5249:
5246:
5242:
5239:
5237:
5234:
5232:
5229:
5228:
5227:
5224:
5220:
5217:
5215:
5212:
5210:
5207:
5206:
5205:
5202:
5200:
5197:
5193:
5190:
5188:
5185:
5183:
5180:
5179:
5178:
5175:
5171:
5168:
5166:
5163:
5162:
5161:
5158:
5156:
5153:
5151:
5148:
5144:
5141:
5139:
5136:
5135:
5134:
5131:
5130:
5128:
5125:
5120:
5117:
5115:
5108:
5105:
5101:
5097:
5092:
5089:
5084:
5080:
5064:
5061:
5059:
5056:
5054:
5051:
5049:
5046:
5044:
5041:
5040:
5039:
5036:
5035:
5033:
5031:
5027:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4985:
4984:
4981:
4980:
4978:
4976:
4972:
4963:
4960:
4956:
4953:
4951:
4948:
4947:
4946:
4943:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4921:
4919:
4916:
4915:
4914:
4911:
4910:
4909:
4906:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4883:
4882:
4879:
4878:
4876:
4874:
4870:
4864:
4861:
4857:
4854:
4852:
4849:
4848:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4810:
4807:
4805:
4802:
4801:
4800:
4797:
4795:
4792:
4791:
4789:
4787:
4784:
4780:
4770:
4767:
4766:
4764:
4756:
4748:
4745:
4743:
4740:
4738:
4735:
4734:
4733:
4730:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4692:
4691:
4688:
4687:
4685:
4679:
4671:
4668:
4666:
4663:
4661:
4658:
4656:
4653:
4652:
4651:
4648:
4646:
4643:
4639:
4636:
4634:
4631:
4629:
4626:
4625:
4624:
4621:
4620:
4618:
4612:
4604:
4601:
4599:
4596:
4595:
4594:
4591:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4568:
4567:
4564:
4560:
4557:
4555:
4552:
4550:
4547:
4546:
4544:
4540:
4537:
4535:
4532:
4530:
4527:
4526:
4525:
4522:
4520:
4517:
4513:
4510:
4508:
4505:
4504:
4503:
4500:
4498:
4495:
4493:
4490:
4489:
4487:
4484:
4476:
4470:
4467:
4465:
4462:
4458:
4455:
4453:
4450:
4448:
4445:
4444:
4443:
4440:
4438:
4435:
4434:
4432:
4426:
4420:
4417:
4411:
4408:
4406:
4403:
4402:
4401:
4398:
4396:
4393:
4392:
4391:
4388:
4384:
4381:
4379:
4376:
4375:
4374:
4371:
4367:
4364:
4362:
4359:
4358:
4357:
4354:
4350:
4347:
4345:
4342:
4340:
4337:
4336:
4335:
4332:
4328:
4325:
4323:
4320:
4319:
4318:
4315:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4292:
4291:
4288:
4286:
4283:
4279:
4276:
4274:
4271:
4270:
4269:
4266:
4264:
4261:
4257:
4254:
4252:
4249:
4248:
4247:
4244:
4243:
4241:
4235:
4232:
4229:
4225:
4221:
4215:
4212:
4208:
4205:
4203:
4200:
4198:
4195:
4194:
4193:
4190:
4188:
4185:
4183:
4180:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4157:
4156:
4153:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4130:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4092:
4089:
4087:
4084:
4082:
4079:
4078:
4077:
4074:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4041:
4040:
4037:
4035:
4032:
4030:
4027:
4023:
4020:
4018:
4015:
4014:
4013:
4010:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3967:
3966:
3963:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3920:
3919:
3916:
3915:
3913:
3910:
3906:
3903:
3899:
3895:
3891:
3886:
3882:
3878:
3874:
3867:
3862:
3860:
3855:
3853:
3848:
3847:
3844:
3830:
3824:
3819:
3818:
3815:
3806:
3801:
3799:
3794:
3792:
3787:
3786:
3783:
3776:
3772:
3771:
3766:
3762:
3758:
3755:
3751:
3748:
3747:
3735:
3731:
3727:
3723:
3719:
3715:
3708:
3700:
3696:
3691:
3686:
3682:
3678:
3677:J. Biol. Chem
3674:
3667:
3659:
3655:
3650:
3645:
3641:
3637:
3633:
3626:
3618:
3614:
3610:
3606:
3602:
3598:
3595:(3): 309–24.
3594:
3590:
3582:
3574:
3570:
3565:
3560:
3556:
3552:
3549:(2): 584–93.
3548:
3544:
3540:
3533:
3525:
3521:
3517:
3513:
3508:
3503:
3500:(5): 731–41.
3499:
3495:
3491:
3484:
3476:
3472:
3468:
3464:
3460:
3456:
3449:
3441:
3437:
3432:
3427:
3423:
3419:
3418:J. Biol. Chem
3415:
3408:
3400:
3396:
3391:
3386:
3382:
3378:
3374:
3367:
3359:
3355:
3350:
3345:
3341:
3337:
3336:J. Biol. Chem
3333:
3326:
3318:
3314:
3309:
3304:
3300:
3296:
3295:J. Biol. Chem
3292:
3285:
3283:
3281:
3272:
3268:
3264:
3260:
3256:
3252:
3248:
3244:
3240:
3236:
3229:
3221:
3217:
3212:
3207:
3203:
3199:
3195:
3191:
3187:
3180:
3178:
3169:
3165:
3160:
3155:
3152:(4): 885–97.
3151:
3147:
3143:
3136:
3128:
3124:
3119:
3114:
3110:
3106:
3103:(2): 411–20.
3102:
3098:
3094:
3087:
3079:
3075:
3070:
3065:
3061:
3057:
3056:J. Biol. Chem
3053:
3046:
3038:
3034:
3029:
3024:
3020:
3016:
3013:(4): 926–33.
3012:
3008:
3004:
2997:
2989:
2985:
2980:
2975:
2971:
2967:
2963:
2959:
2955:
2948:
2940:
2936:
2931:
2926:
2922:
2918:
2914:
2910:
2906:
2899:
2891:
2887:
2882:
2877:
2873:
2869:
2865:
2861:
2857:
2850:
2848:
2839:
2835:
2830:
2825:
2821:
2817:
2813:
2809:
2805:
2798:
2790:
2786:
2782:
2778:
2774:
2770:
2767:(3): 507–19.
2766:
2762:
2755:
2747:
2743:
2738:
2733:
2729:
2725:
2721:
2717:
2713:
2706:
2698:
2694:
2689:
2684:
2680:
2676:
2672:
2668:
2664:
2657:
2649:
2645:
2640:
2635:
2630:
2625:
2621:
2617:
2616:J. Biol. Chem
2613:
2606:
2598:
2594:
2589:
2584:
2580:
2576:
2572:
2568:
2564:
2557:
2549:
2545:
2540:
2535:
2530:
2525:
2521:
2517:
2513:
2506:
2498:
2494:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2457:
2449:
2445:
2440:
2435:
2431:
2427:
2423:
2416:
2408:
2404:
2399:
2394:
2389:
2384:
2380:
2376:
2372:
2365:
2357:
2353:
2348:
2343:
2339:
2335:
2331:
2327:
2323:
2316:
2308:
2304:
2299:
2294:
2290:
2286:
2282:
2275:
2267:
2263:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2226:
2218:
2214:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2177:
2169:
2165:
2161:
2157:
2152:
2147:
2143:
2139:
2135:
2128:
2120:
2116:
2111:
2106:
2102:
2098:
2094:
2090:
2086:
2079:
2071:
2067:
2063:
2059:
2052:
2044:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2009:
2001:
1997:
1992:
1987:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1948:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1913:
1905:
1899:
1891:
1887:
1883:
1879:
1875:
1871:
1867:
1863:
1856:
1854:
1838:
1834:
1828:
1820:
1816:
1810:
1802:
1798:
1792:
1785:
1781:
1776:
1774:
1772:
1764:
1760:
1755:
1753:
1751:
1746:
1735:
1732:
1729:
1726:
1724:
1721:
1718:
1715:
1712:
1709:
1706:
1703:
1700:
1697:
1694:
1691:
1688:
1685:
1682:
1679:
1676:
1673:
1670:
1667:
1664:
1661:
1658:
1655:
1652:
1649:
1648:
1646:
1644:
1634:
1631:
1627:
1623:
1612:
1608:
1606:
1601:
1597:
1595:
1591:
1587:
1583:
1574:
1572:
1568:
1564:
1559:
1557:
1554:from surface
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1525:
1515:
1512:
1508:
1504:
1500:
1496:
1487:
1483:
1480:
1475:
1472:
1468:
1464:
1460:
1456:
1452:
1448:
1444:
1440:
1436:
1432:
1422:
1419:
1416:
1414:
1410:
1406:
1402:
1401:proliferation
1398:
1393:
1391:
1387:
1377:
1375:
1374:protein dimer
1371:
1367:
1363:
1359:
1348:
1346:
1342:
1337:
1335:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1279:
1274:
1270:
1266:
1263:
1259:
1252:
1250:
1247:
1243:
1239:
1235:
1232:
1228:
1224:
1217:
1215:
1209:
1205:
1202:
1196:
1194:
1188:
1184:
1181:
1177:
1170:
1168:
1162:
1158:
1155:
1149:
1147:
1141:
1137:
1134:
1132:RefSeq (mRNA)
1130:
1123:
1122:
1117:
1113:
1110:
1104:
1103:
1098:
1094:
1091:
1089:
1085:
1078:
1077:
1072:
1068:
1065:
1059:
1058:
1053:
1049:
1046:
1044:
1040:
1033:
1032:
1027:
1023:
1020:
1014:
1013:
1008:
1004:
1001:
999:
995:
992:
989:
987:
984:
980:
977:
973:
969:
962:
958:
953:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
753:
751:
748:
747:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
649:E-box binding
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
592:
591:Gene ontology
588:
584:
572:
567:
563:
558:
555:
553:
549:
541:
536:
525:
521:
517:
513:
509:
505:
501:
498:tongue muscle
497:
493:
489:
488:
485:
481:
476:
473:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
426:
423:
419:
414:
411:
410:
407:
405:
401:
399:
398:
394:
393:
390:
388:
384:
380:
376:
372:
364:
359:
355:
351:
346:
336:
332:
325:
318:
312:
305:
297:
293:
289:
284:
280:
275:
271:
263:
258:
254:
250:
245:
235:
231:
224:
217:
211:
204:
200:
194:
190:
186:
181:
177:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
120:
115:
108:
103:
98:
87:
85:
79:
74:
71:
70:
66:
63:
56:
52:
47:
43:
39:
34:
29:
26:
22:
9273:
9228:
9184:
9142:
9134:
9106:
9100:
9094:
9063:
9028:
9016:
8953:
8930:
8912:
8880:
8851:
8732:
8662:
8636:
8588:
8491:
8438:
8358:
8346:
8300:
8292:
8198:
8144:
8117:
8109:
8080:
8069:
7813:FOX proteins
7773:winged helix
7765:
7736:
7719:
7662:
7582:
7556:
7434:
7400:
7383:
7361:
7344:
7277:
7245:
7099:
7062:
7043:
6989:
6955:
6949:
6643:
6637:
6626:
6620:Antennapedia
6618:
6605:
6593:
6587:
6556:
6514:
6492:
6469:
6448:
6206:
6159:
6105:
6051:
5964:
5942:
5920:
5898:
5881:
5839:
5768:
5650:
5618:
5570:
5542:
5522:
5497:
5460:
5426:Progesterone
5379:
5275:
5123:
5109:
5103:
5087:
5029:
4982:
4974:
4872:
4782:
4731:
4689:
4649:
4622:
4592:
4565:
4399:
4389:
4372:
4355:
4294:
4267:
4223:
4191:
4154:
4011:
3901:
3889:
3828:
3768:
3750:MyoD+Protein
3717:
3714:Biochemistry
3713:
3707:
3680:
3676:
3666:
3639:
3635:
3625:
3592:
3588:
3581:
3546:
3542:
3532:
3497:
3493:
3483:
3461:(1): 34–43.
3458:
3455:J. Mol. Biol
3454:
3448:
3421:
3417:
3407:
3380:
3376:
3366:
3339:
3335:
3325:
3298:
3294:
3238:
3234:
3228:
3193:
3189:
3149:
3145:
3135:
3100:
3096:
3086:
3059:
3055:
3045:
3010:
3006:
2996:
2961:
2957:
2947:
2912:
2908:
2898:
2863:
2859:
2811:
2807:
2797:
2764:
2760:
2754:
2719:
2715:
2705:
2670:
2667:Cell Reports
2666:
2656:
2619:
2615:
2605:
2570:
2566:
2556:
2519:
2515:
2505:
2470:
2466:
2456:
2429:
2425:
2415:
2378:
2374:
2364:
2329:
2325:
2315:
2288:
2284:
2274:
2239:
2235:
2225:
2190:
2187:Cell Reports
2186:
2176:
2141:
2137:
2127:
2092:
2088:
2078:
2061:
2057:
2051:
2018:
2014:
2008:
1973:
1969:
1955:
1922:
1918:
1912:
1898:
1865:
1861:
1840:. Retrieved
1836:
1827:
1818:
1809:
1800:
1791:
1640:
1637:Interactions
1618:
1598:
1580:
1560:
1534:, including
1521:
1492:
1476:
1428:
1420:
1417:
1394:
1383:
1354:
1338:
1293:
1289:
1288:
1211:
1190:
1164:
1143:
1119:
1100:
1074:
1055:
1029:
1010:
990:
985:
740:nuclear body
402:
395:
122:External IDs
81:
25:
8954:(4.11) Runt
6609:Homeodomain
6207:zinc finger
5543:subfamily 0
5523:subfamily 6
5498:subfamily 5
5461:subfamily 4
5380:subfamily 3
5276:subfamily 2
5124:subfamily 1
5091:Zinc finger
4334:Neurogenins
3902:(1.1) Basic
3811:PDB gallery
2473:(2): 1–12.
2432:: 516–526.
2064:: 267–278.
1544:cis-element
1332:(Myf6). In
715:nucleoplasm
604:DNA binding
361:46,028,523
348:46,025,898
260:17,722,136
247:17,719,571
100:Identifiers
9290:Categories
7487:POU domain
6627:ANTP class
6557:(2.6) WRKY
5840:GLI family
4975:(1.5) RF-X
4873:(1.4) NF-1
3342:(1): 5–8.
1786:, May 2017
1765:, May 2017
1742:References
1429:MyoD is a
1425:Mechanisms
1397:cell cycle
1366:adipoblast
1362:fibroblast
1345:myogenesis
522:knee joint
406:(ortholog)
143:HomoloGene
9274:see also
9115:Apetala 2
7769:Fork head
6449:(2.4) Cys
5651:(2.3) Cys
4383:Scleraxis
3146:Mol. Cell
1970:Dev. Biol
1837:UniProtKB
1565:, Wnt5b,
1507:Cyclin D1
1443:promoters
1435:chromatin
1214:NP_034996
1193:NP_002469
1167:NM_010866
1146:NM_002478
976:Orthologs
730:cytoplasm
720:myofibril
151:GeneCards
8592:MADS box
6732:Homeobox
6644:Hox-like
6638:protoHOX
5399:Estrogen
5394:Androgen
5248:Rev-ErbA
4786:bHLH-ZIP
4761:bHLH-COE
4300:Myogenin
3699:12947115
3636:Oncogene
3617:21581966
3524:16252710
3475:18674781
3440:12145280
3377:Oncogene
3263:15029197
3220:11285237
3168:11684023
3078:10764802
3037:10022835
2988:10601020
2838:11463815
2789:44966899
2697:25242327
2648:21127072
2597:15743821
2548:25364710
2522:(1): 1.
2497:25651906
2448:24864103
2407:25006242
2356:25715926
2307:24525185
2266:25737281
2217:25242327
2168:17769090
2138:Mech Dev
2119:23756045
2000:21798255
1962:Moens CB
1947:27322641
1890:37741454
1782:–
1761:–
1643:interact
1556:ectoderm
1511:enhancer
1469:and the
1447:myoblast
1409:myogenin
1386:mesoderm
1380:Function
1326:myogenin
1262:Wikidata
955:Sources:
456:testicle
8992:RUNX1T1
8972:CBFA2T3
8967:CBFA2T2
8847:TCF/LEF
6956:NK-like
6950:metaHOX
6653:ParaHox
6594:domains
5285:COUP-TF
4759:Group F
4682:Group E
4615:Group D
4479:Group C
4429:Group B
4373:Paraxis
4238:Group A
3775:PDBe-KB
3765:UniProt
3734:9184158
3658:9692544
3609:8381715
3573:9001211
3516:8797820
3399:9528857
3358:8380166
3317:9242638
3271:4427531
3243:Bibcode
3127:9862959
3028:1171185
2979:1171761
2939:9234731
2890:9001254
2781:1310896
2746:9001254
2688:4180018
2639:3037682
2588:1061592
2539:4206996
2488:4370097
2398:4156083
2347:4400312
2257:4358404
2208:4180018
2160:9076685
2110:3775946
2070:2562185
2043:3175662
2023:Bibcode
2015:Science
1991:3360969
1939:8269513
1882:3690668
1842:17 July
1784:Ensembl
1763:Ensembl
1630:RNAP II
1626:H3K27ac
1622:H3K4me1
1358:Science
1351:History
1298:protein
1296:, is a
1088:UniProt
1043:Ensembl
982:Species
961:QuickGO
735:cytosol
725:nucleus
490:myotome
381:pattern
239:11p15.1
107:Aliases
7705:Bicoid
6970:BARHL2
6965:BARHL1
6547:JMJD1B
6460:HIVEP1
4945:I-SMAD
4913:R-SMAD
4831:MLXIPL
4586:Period
4512:ARNTL2
4317:NeuroD
3770:P10085
3756:(MeSH)
3732:
3697:
3656:
3615:
3607:
3571:
3564:231783
3561:
3522:
3514:
3473:
3438:
3397:
3356:
3315:
3269:
3261:
3235:Nature
3218:
3211:145490
3208:
3190:EMBO J
3166:
3125:
3118:148194
3115:
3076:
3035:
3025:
3007:EMBO J
2986:
2976:
2958:EMBO J
2937:
2930:232327
2927:
2888:
2881:231826
2878:
2836:
2826:
2787:
2779:
2744:
2737:231826
2734:
2695:
2685:
2646:
2636:
2595:
2585:
2546:
2536:
2495:
2485:
2446:
2405:
2395:
2354:
2344:
2305:
2264:
2254:
2215:
2205:
2166:
2158:
2117:
2107:
2068:
2041:
1998:
1988:
1945:
1937:
1888:
1880:
1730:, and
1645:with:
1628:, and
1600:NFATc1
1503:Cyclin
1479:SETDB1
1399:(halt
1328:, and
1248:search
1246:PubMed
1121:P10085
1102:P15172
998:Entrez
552:BioGPS
436:glutes
131:159970
9255:Sigma
9120:EREBP
9104:EREBP
9095:(0.5)
9064:(0.3)
8987:RUNX3
8982:RUNX2
8977:RUNX1
8921:TFCP2
8842:SSRP1
8663:(4.7)
8653:TBPL1
8637:(4.6)
8589:(4.4)
8439:(4.2)
8380:NFKB2
8375:NFKB1
8370:NF-κB
8359:(4.1)
8283:MYBL2
8070:(3.4)
7766:(3.3)
7715:BICD2
7690:SHOX2
7658:PROP1
7642:PRRX
7552:SATB2
7497:BRN-3
7492:PIT-1
7384:PKNOX
7299:TALE
7295:NOBOX
7268:HESX1
7241:CUTL1
7223:other
7117:NANOG
6980:BARX2
6975:BARX1
6727:MEOX2
6722:MEOX1
6606:(3.1)
6515:JARID
6488:GRLF1
6483:DIDO1
6143:Zbtb7
6133:TSHZ3
6101:PRDM9
5899:HIVEP
5764:ATBF1
5718:TFIIH
5703:TFIIF
5686:TFIIE
5681:TFIID
5676:TFIIB
5671:TFIIA
5641:TRPS1
5507:LRH-1
5485:NURR1
5475:NGFIB
5303:Ear-2
5104:(2.1)
4846:SREBP
4783:(1.3)
4545:NPAS
4534:EPAS1
4519:CLOCK
4507:ARNTL
4481:bHLH-
4457:n-Myc
4452:l-Myc
4447:c-Myc
4437:FIGLA
4419:Twist
4378:TCF15
4285:MESP2
4263:ATOH1
4256:ASCL2
4251:ASCL1
4182:NFIL3
4113:GABPA
4108:DDIT3
4039:C/EBP
4034:BLZF1
3995:c-Jun
3985:FOSL2
3980:FOSL1
3970:c-Fos
3613:S2CID
3520:S2CID
3267:S2CID
2829:87255
2785:S2CID
2164:S2CID
1943:S2CID
1886:S2CID
1728:STAT3
1687:HDAC1
1681:EP300
1663:CSRP3
1651:C-jun
1594:NF-κB
1590:HDAC4
1586:MEF2C
1582:IFRD1
1567:Wnt7a
1563:Wnt5a
1552:Wnt7a
1540:Wnt3a
1439:E-box
1031:17927
991:Mouse
986:Human
957:Amigo
494:wrist
464:gonad
404:Mouse
397:Human
344:Start
279:Mouse
243:Start
176:Human
155:MYOD1
139:97275
114:MYOD1
31:MYOD1
21:MyD88
9224:MNDA
9143:ARID
9098:AP-2
9085:RBL2
9080:RBL1
9054:HBP1
9037:HMGA
8944:YBX1
8939:CSDA
8874:LEF1
8706:HMGN
8679:HMGB
8600:Mef2
8579:MYRF
8567:TBR2
8562:TBR1
8510:TP63
8450:STAT
8442:STAT
8402:NFAT
8395:RELB
8390:RELA
8345:(4)
8226:FLI1
8192:SPIB
7893:D4L6
7888:D4L5
7883:D4L4
7878:D4L3
7873:D4L1
7737:PITX
7700:VSX2
7695:VSX1
7685:SHOX
7663:PHOX
7345:MEIS
7273:HOPX
7209:VAX2
7204:VAX1
7199:TLX3
7194:TLX2
7189:TLX1
7184:NATO
7167:HMX3
7162:HMX2
7157:HMX1
7095:LBX2
7090:LBX1
7080:HHEX
6939:MNX1
6934:GBX2
6929:GBX1
6717:Evx2
6712:Evx1
6680:PDX1
6675:Xlox
6565:WRKY
6478:AIRE
6437:804A
6160:ZBTB
6106:SALL
6096:OSR1
6091:MYT1
6086:MTF1
5921:IKZF
5860:REST
5835:GFI1
5830:ERV3
5798:E4F1
5793:CTCF
5582:GATA
5552:DAX1
5532:GCNF
5480:NOR1
5308:HNF4
5177:PPAR
5110:(Cys
5038:AP-2
4908:SMAD
4863:USF1
4836:MXI1
4816:MITF
4809:MXD3
4804:MXD1
4794:AP-4
4769:EBF1
4645:Pho4
4623:BHLH
4502:ARNT
4497:AHRR
4469:TCF4
4464:MXD4
4395:LYL1
4356:OLIG
4310:MYF6
4305:MYF5
4295:MyoD
4268:HAND
4246:AS-C
4228:bHLH
4214:XBP1
4118:GCN4
4098:CREM
4076:CREB
4029:BATF
4012:BACH
4005:JunD
4000:JUNB
3990:JDP2
3975:FOSB
3965:AP-1
3923:AATF
3909:bZIP
3875:and
3829:1mdy
3763:for
3730:PMID
3695:PMID
3654:PMID
3605:PMID
3589:Cell
3569:PMID
3512:PMID
3494:Cell
3471:PMID
3436:PMID
3395:PMID
3354:PMID
3313:PMID
3259:PMID
3216:PMID
3164:PMID
3123:PMID
3074:PMID
3033:PMID
2984:PMID
2935:PMID
2886:PMID
2834:PMID
2777:PMID
2761:Cell
2742:PMID
2693:PMID
2644:PMID
2593:PMID
2544:PMID
2493:PMID
2444:PMID
2403:PMID
2352:PMID
2303:PMID
2262:PMID
2213:PMID
2156:PMID
2115:PMID
2066:PMID
2039:PMID
1996:PMID
1935:PMID
1919:Cell
1878:PMID
1862:Cell
1844:2019
1734:TCF3
1705:MDFI
1605:p300
1571:Wnt4
1569:and
1536:Myf5
1528:Pax7
1526:and
1524:Pax3
1463:LSD1
1461:and
1459:p300
1455:Mef2
1413:CDKs
1407:and
1390:mRNA
1364:and
1330:MRF4
1322:Myf5
1314:bHLH
1290:MyoD
1012:4654
387:Bgee
335:Band
296:Chr.
234:Band
193:Chr.
147:7857
127:OMIM
84:1MDY
65:RCSB
62:PDBe
9251:Rho
9229:NFY
9202:MLL
9185:IFI
9180:CAP
8962:CBF
8881:TOX
8852:TCF
8837:SRY
8750:SOX
8733:HNF
8674:BBX
8648:TBP
8627:SRF
8572:TFT
8522:TBX
8515:p73
8505:p53
8385:REL
8278:MYB
8199:ETV
8187:ERG
8172:ETS
8167:ERF
8145:ELK
8140:EGF
8118:ELF
8082:HSF
7781:E2F
7720:OTX
7710:GSC
7680:RAX
7591:PAX
7557:ZEB
7530:3/4
7480:21A
7435:PHF
7401:SIX
7362:PBX
7338:MKX
7303:IRX
7278:LMX
7246:FHL
7236:CRX
7231:ARX
7177:6-2
7172:6-1
7152:3-2
7147:3-1
7142:2-5
7137:2-3
7132:2-2
7127:2-1
7122:NKX
7100:MSX
7085:HLX
7045:EMX
7007:DLX
6990:DBX
6985:BSX
6922:D13
6917:D12
6912:D11
6907:D10
6877:C13
6872:C12
6867:C11
6862:C10
6832:B13
6782:A13
6777:A11
6772:A10
6687:Cdx
6658:Gsx
6588:(3)
6493:ING
6432:655
6427:649
6422:644
6417:638
6412:593
6407:471
6402:452
6397:451
6392:423
6387:384
6382:366
6377:365
6372:350
6367:346
6362:330
6357:318
6352:300
6347:281
6342:268
6337:267
6332:259
6327:239
6322:238
6317:219
6312:217
6307:202
6302:165
6297:148
6292:146
6287:143
6247:33B
6138:WT1
5965:KLF
5943:ILF
5882:HIC
5875:YY1
5803:EGR
5786:11B
5781:11A
5770:BCL
5753:3C2
5748:3C1
5655:His
5619:MTA
5557:SHP
5512:SF1
5470:NUR
5369:TLX
5330:RXR
5325:PNR
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