141:
MCC is pure partially depolymerized cellulose synthesized from α-cellulose precursor. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, mechanical grinding, ultrasonication, steam explosion and acid hydrolysis. The latter process can be done using mineral
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The MCC is a valuable additive in pharmaceutical, food, cosmetic and other industries. Different properties of MCC are measured to qualify its suitability to such utilization, namely particle size, density, compressibility index, angle of repose, powder porosity, hydration swelling capacity, moisture
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Each microfibril exhibits a high degree of three-dimensional internal bonding resulting in a crystalline structure that is insoluble in water and resistant to reagents. There are, however, relatively weak segments of the microfibril with weaker internal bonding. These are called amorphous regions;
389:
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Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) or differential scanning calorimetry (DSC) are also important to predict the thermal behavior of the MCC upon heat stresses.
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some argue that they are more accurately called dislocations, because of the single-phase structure of microfibrils. The crystalline region is isolated to produce microcrystalline cellulose.
390:
https://www.mastcellaction.org/assets/_/2021/09/13/29fd2269-847a-4ab3-9295-d6432316233a/recognition-and-management-of-excipient-reactivity-in-mast-cell-activation-syndrome.pdf?v=1
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increasing agent, binder, bulking agent, emulsion stabilizer, slip modifier, and texturizer, which can be found in various hair and skin care products as well as
187:
133:
sorption capacity, moisture content, crystallinity index, crystallite size, and mechanical properties such as hardness and tensile strength.
31:
150:, HCl and HBr as well as ionic liquids. The role of these reagents is to destroy the amorphous regions leaving the crystalline domains.
337:"Hindi, S. S. Z. 2016. Microcrystalline cellulose: Its specifications and pharmaceutical processing. Biocrystals Journal. 1 (1): 26-38"
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The degree of polymerization is typically less than 400. The MCC particles with size lower than 5 μm must not be more than 10%.
264:
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Approved within the
European Union as a thickener, stabilizer or emulsifier, microcrystalline cellulose was granted the
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units connected by a 1-4 beta glycosidic bond. These linear cellulose chains are bundled together as
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At least one case of an allergic reaction to microcrystalline cellulose has been documented.
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Decorative skin and hair cosmetics containing microcrystalline cellulose as enhancing agent
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8:
55:
406:
290:
241:
214:
213:
Matrosovich, Mikhail; Tatyana
Matrosovich; Wolfgang Garten; Hans-Dieter Klenk (2006).
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35:
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excipient trigger depending on the source and processing method of the cellulose.
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27:
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215:"New low-viscosity overlay medium for viral plaque assays"
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E460(i) with basic cellulose given the number E460.
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313:"Microcrystalline Cellulose | Cosmetics Info"
62:for counting viruses, as an alternative to
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230:
399:
366:"Letter from Allergy Clinic of Tulsa"
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13:
54:. The most common form is used in
14:
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167:It has been noted as a potential
188:"Agricultural Marketing Service"
58:or tablets. It is also used in
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283:
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1:
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121:, anti-caking agent, aqueous
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69:
7:
10:
423:
20:Microcrystalline cellulose
26:) is a term for refined
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232:10.1186/1743-422X-3-63
225:. BioMed Central: 63.
86:spiralled together in
74:A naturally occurring
64:carboxymethylcellulose
317:www.cosmeticsinfo.org
46:, an extender, and a
78:, it is composed of
56:vitamin supplements
160:Allergic reactions
36:anti-caking agent
30:and is used as a
16:Refined wood pulp
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381:
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368:. Archived from
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343:. Archived from
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267:. Archived from
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219:Virology Journal
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190:. Archived from
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271:on 5 March 2016
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142:acids such as H
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109:MCC has use in
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52:food production
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12:
11:
5:
420:
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194:on 8 July 2014
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96:
71:
68:
40:fat substitute
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6:
4:
3:
2:
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408:
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404:
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391:
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372:on 2017-03-23
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347:on 2016-05-08
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60:plaque assays
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53:
49:
48:bulking agent
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37:
33:
29:
25:
21:
385:
374:. Retrieved
370:the original
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349:. Retrieved
345:the original
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331:
320:. Retrieved
316:
307:
297:, retrieved
295:, 2004-01-06
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273:. Retrieved
269:the original
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196:. Retrieved
192:the original
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140:
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101:
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73:
23:
19:
18:
341:BioCrystals
84:microfibril
376:2012-02-03
351:2016-04-22
322:2018-05-21
299:2018-05-21
275:9 November
198:9 November
175:References
88:plant cell
44:emulsifier
32:texturizer
407:Cellulose
137:Synthesis
123:viscosity
119:absorbent
111:cosmetics
70:Structure
28:wood pulp
401:Category
251:16945126
115:abrasive
104:E number
90:walls.
265:"FOODS"
242:1564390
80:glucose
76:polymer
249:
239:
127:makeup
113:as an
42:, an
34:, an
277:2016
247:PMID
200:2016
169:MCAS
98:Uses
38:, a
237:PMC
227:doi
50:in
24:MCC
403::
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245:.
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217:.
146:SO
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