154:(GPCRs), which constitute the largest single protein family involved in the transduction of hormonal signals and neurotransmitters. Their physiological significance makes them prime targets in drug development, and over a third of existing drugs use GPCRs as their target site of action. Bouvier's work in the regulation of receptors led to new paradigms (inverse agonism; pharmacological chaperones; receptor polymerization; and pluridimensionality of signaling), which, coupled with the development of
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138:(2012 Nobel Prize in Chemistry). Bouvier is a professor in the Department of Biochemistry and Molecular Medicine at the Faculty of Medicine of Université de Montréal and a principal investigator at the Institute for Research in Immunology and Cancer at Université de Montréal.
158:-based methods, have a direct impact on drug discovery. He has authored over 260 scientific articles, filed 36 patent applications, and delivered over 400 lectures as a guest lecturer. Bouvier holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology.
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