687:
1975:
664:
586:
561:
6119:
6104:
6089:
5984:
5744:
945:
938:
6149:
6134:
5909:
693:
592:
5924:
6179:
5939:
5774:
5759:
6164:
6074:
5804:
5789:
6059:
6044:
5894:
5879:
5864:
5849:
5834:
5819:
6194:
5969:
5954:
5999:
2270:. (These ovine sites correspond to human sites 133, 151, and 168.) Polymorphisms of the PrP-VRQ form and PrP-ARQ form are associated with increased susceptibility, whereas PrP-ARR is associated with resistance. The National Scrapie Plan of the UK aims to breed out these scrapie polymorphisms by increasing the frequency of the resistant allele. However, PrP-ARR polymorphisms are susceptible to atypical scrapie, so this may prove unfruitful.
6029:
6014:
2570:(the building-blocks of proteins) in the prion protein. Others insert additional amino acids into the protein or cause an abnormally short protein to be made. These mutations cause the cell to make prion proteins with an abnormal structure. The abnormal protein PrP accumulates in the brain and destroys nerve cells, which leads to the mental and behavioral features of prion diseases.
38:
2468:
Modulation of signal transduction pathways has been demonstrated in cross-linking with antibodies and ligand-binding (hop/STI1 or copper). Given the diversity of interactions, effects, and distribution, PrP has been proposed as dynamic surface protein functioning in signaling pathways. Specific sites
2240:
from PrP, but identical primary sequence. Whereas PrP has largely alpha helical and disordered domains, PrP has no alpha helix and an amyloid fibril core composed of a stack of PrP molecules glued together by parallel in-register intermolecular beta sheets. This refolding renders the PrP isoform
2561:
The conversion of PrP to PrP conformation is the mechanism of transmission of fatal, neurodegenerative transmissible spongiform encephalopathies (TSE). This can arise from genetic factors, infection from external source, or spontaneously for reasons unknown. Accumulation of PrP corresponds with
2378:
PrP is present in both the pre- and post-synaptic compartments, with the greatest concentration in the pre-synaptic portion. Considering this and PrP's suite of behavioral influences, the neural cell functions and interactions are of particular interest. Based on the copper ligand, one proposed
2807:
In 2006 the production of cattle lacking PrP form of the major prion protein (PrP) protein was reported which were resistant to prion propagation with no apparent developmental abnormalities. Besides the study of bovine products free of prion proteins another use could be so that human
2724:
models of
Alzheimer's, attenuated the epilepsy-induced death phenotype seen in a subset of these animals. Taken collectively, recent evidence suggests PRNP may be important for conducing the neurotoxic effects of soluble Aβ-oligomers and the emergent disease state of Alzheimer's.
64:
2287:
mice to investigate deficiencies and differences. Initial attempts produced two strains of PrP-null mice that show no physiological or developmental differences when subjected to an array of tests. However, more recent strains have shown significant cognitive abnormalities.
5475:
Giovagnoli AR, Di Fede G, Aresi A, Reati F, Rossi G, Tagliavini F (December 2008). "Atypical frontotemporal dementia as a new clinical phenotype of
Gerstmann-Straussler-Scheinker disease with the PrP-P102L mutation. Description of a previously unreported Italian family".
2369:
have been linked with cognitive impairment in the elderly as well as earlier cognitive decline. All of these studies investigated differences in codon 129, indicating its importance in the overall functionality of PrP, in particular with regard to memory.
3066:
Robakis NK, Devine-Gage EA, Jenkins EC, Kascsak RJ, Brown WT, Krawczun MS, Silverman WP (October 1986). "Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain".
2447:
Though present, very low levels of PrP exist in the liver and could be associated with liver fibrosis. Presence in the pituitary has been shown to affect neuroendocrine function in amphibians, but little is known concerning mammalian pituitary PrP.
2252:. Based on the progressive nature of spongiform encephalopathies, the predominant hypothesis posits that the change from normal PrP is caused by the presence and interaction with PrP. Strong support for this is taken from studies in which
2443:
PrP-null mice provide clues to a role in muscular physiology when subjected to a forced swimming test, which showed reduced locomotor activity. Aging mice with an overexpression of PRNP showed significant degradation of muscle tissue.
2460:
has led to speculation on involvement in development. A wide range of studies has been conducted investigating the role in cell proliferation, differentiation, death, and survival. Engagement of PrP has been linked to activation of
2341:, a predominantly hippocampal-function, is decreased in the null mice and can be recovered with the reinstatement of PrP in neurons; this indicates that loss of PrP function is the cause. The interaction of hippocampal PrP with
2352:
Further support for PrP's role in memory formation is derived from several population studies. A test of healthy young humans showed increased long-term memory ability associated with an MM or MV genotype when compared to VV.
2410:
Though most attention is focused on PrP's presence in the nervous system, it is also abundant in immune system tissue. PrP immune cells include hematopoietic stem cells, mature lymphoid and myeloid compartments, and certain
5428:
He J, Li X, Yang J, Huang J, Fu X, Zhang Y, Fan H (March 2013). "The association between the methionine/valine (M/V) polymorphism (rs1799990) in the PRNP gene and the risk of
Alzheimer disease: an update by meta-analysis".
4513:
Del Bo R, Comi GP, Giorda R, Crimi M, Locatelli F, Martinelli-Boneschi F, et al. (June 2003). "The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects".
2759:. The decreased risk in V allele carriers is further limited to late-onset Alzheimer's disease only (≥ 65 years). PRNP can also functionally interact with polymorphisms in two other genes implicated in Alzheimer's,
2469:
along the protein bind other proteins, biomolecules, and metals. These interfaces allow specific sets of cells to communicate based on level of expression and the surrounding microenvironment. The anchoring on a
2004:
PrP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9 to 99.6% similarity in
2607:– TSE in humans, transmitted via funerary cannibalism. Generally, affected family members were given, by tradition, parts of the central nervous system according to ritual when consuming deceased family members.
700:
599:
5062:
Collins S, McLean CA, Masters CL (September 2001). "Gerstmann-Sträussler-Scheinker syndrome,fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies".
4283:
Criado JR, Sánchez-Alavez M, Conti B, Giacchino JL, Wills DN, Henriksen SJ, et al. (2005). "Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons".
4156:
Roesler R, Walz R, Quevedo J, de-Paris F, Zanata SM, Graner E, et al. (August 1999). "Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C)".
4600:
Croes EA, Dermaut B, Houwing-Duistermaat JJ, Van den Broeck M, Cruts M, Breteler MM, et al. (August 2003). "Early cognitive decline is associated with prion protein codon 129 polymorphism".
2256:-knockout mice are resistant to the introduction of PrP. Despite widespread acceptance of the conformation conversion hypothesis, some studies mitigate claims for a direct link between PrP and
4240:
Cagampang FR, Whatley SA, Mitchell AL, Powell JF, Campbell IC, Coen CW (1999). "Circadian regulation of prion protein messenger RNA in the rat forebrain: a widespread and synchronous rhythm".
4737:
Kardos J, Kovács I, Hajós F, Kálmán M, Simonyi M (August 1989). "Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability".
4643:
Kachiwala SJ, Harris SE, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ (September 2005). "Genetic influences on oxidative stress and their association with normal cognitive ageing".
4557:
Berr C, Richard F, Dufouil C, Amant C, Alperovitch A, Amouyel P (September 1998). "Polymorphism of the prion protein is associated with cognitive impairment in the elderly: the EVA study".
2136:
are confirmed PrP ligands that bind to its octarepeat region. Ligand binding causes a conformational change with unknown effect. Heavy metal binding at PrP has been linked to resistance to
1966:(vCJD). Similarities exist between kuru, thought to be due to human ingestion of diseased individuals, and vCJD, thought to be due to human ingestion of BSE-tainted cattle products.
3324:
Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, et al. (June 2005). "Anchorless prion protein results in infectious amyloid disease without clinical scrapie".
2317:
at codon 178, which corroborates PrP's involvement in sleep-wake cycles. In addition, circadian regulation has been demonstrated in PrP mRNA, which cycles regularly with day-night.
4113:
Nico PB, de-Paris F, Vinadé ER, Amaral OB, Rockenbach I, Soares BL, et al. (July 2005). "Altered behavioural response to acute stress in mice lacking cellular prion protein".
4386:
Coitinho AS, Freitas AR, Lopes MH, Hajj GN, Roesler R, Walz R, et al. (December 2006). "The interaction between prion protein and laminin modulates memory consolidation".
3723:
Kraus A, Hoyt F, Schwartz CL, Hansen B, Artikis E, Hughson AG, et al. (November 2021). "High-resolution structure and strain comparison of infectious mammalian prions".
2601:(mad-cow disease) – fatal neurodegenerative disease in cows, which can be transmitted to humans by ingestion of brain, spinal, or digestive tract tissue of an infected cow
6118:
6103:
6088:
7095:
5983:
2040:, and this proves to be integral to the transmission of conformational change; secreted PrP lacking the anchor component is unaffected by the infectious isoform.
4070:
Katamine S, Nishida N, Sugimoto T, Noda T, Sakaguchi S, Shigematsu K, et al. (December 1998). "Impaired motor coordination in mice lacking prion protein".
3872:
Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J (February 2011). "Prion propagation and toxicity in vivo occur in two distinct mechanistic phases".
2118:-protein, but, so far, no such compound has been identified. However, a large body of research has developed on candidates and their interaction with the PrP.
5743:
6234:
2577:
gene (called polymorphisms) do not cause prion diseases but may affect a person's risk of developing these diseases or alter the course of the disorders. An
2283:
The strong association to neurodegenerative diseases raises many questions of the function of PrP in the brain. A common approach is using PrP-knockout and
3023:
Liao YC, Lebo RV, Clawson GA, Smuckler EA (July 1986). "Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications".
2808:
pharmaceuticals can be made in their blood without the danger that those products might get contaminated with the infectious agent that causes mad cow.
1518:
1499:
522:
2784:
2525:
1955:
5019:
Kovács GG, Trabattoni G, Hainfellner JA, Ironside JW, Knight RS, Budka H (November 2002). "Mutations of the prion protein gene phenotypic spectrum".
2929:
Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ (August 1986). "Molecular cloning of a human prion protein cDNA".
6148:
6133:
7085:
6212:
2911:
2893:
2156:
copper into cells from the surrounding environment. Researchers have also proposed roles for PrP in cell signaling or in the formation of
61:
2299:
results in decreased motor coordination. However, this effect is not a direct result of PrP's absence, and rather arises from increased
7065:
1793:
7927:
6251:
6227:
1786:
2402:
outgrowth. The PrP-activated signal transduction pathway is associated with axon and dendritic outgrowth with a series of kinases.
1904:
7658:
2490:
2432:
5908:
3575:"Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro"
7646:
7424:
2391:(LTP). This effect can be positive or negative and is due to changes in neuronal excitability and synaptic transmission in the
5923:
8259:
7710:
7705:
7651:
7431:
5723:
2664:-knockout mice were found to be indistinguishable from control with respect to both neuronal death rates and measurements of
2303:
gene expression. Other observed differences include reduced stress response and increased exploration of novel environments.
1963:
2876:
23:, infectious forms of proteins which have so far been observed in almost all instances to be forms of PRNP, but need not be.
8264:
7164:
7090:
6220:
4782:"The persistence of long-term memory: a molecular approach to self-sustaining changes in learning-induced synaptic growth"
8193:
8188:
8183:
8178:
7105:
2855:
2708:
deletion has been prophylactically implemented by the cattle industry without apparent harm. In mice, this same deletion
5520:
3445:
Linden R, Martins VR, Prado MA, Cammarota M, Izquierdo I, Brentani RR (April 2008). "Physiology of the prion protein".
3289:
Schätzl HM, Da Costa M, Taylor L, Cohen FE, Prusiner SB (January 1995). "Prion protein gene variation among primates".
2431:
activation is accompanied by a strong up-regulation of PrP, though it is not requisite. The lack of immunoresponse to
8158:
6178:
5938:
1931:
2387:
mechanism, a calcium modulator, or a sensor for copper or oxidative stress. Loss of PrP function has been linked to
686:
7394:
5773:
5758:
2598:
1927:
1923:
6163:
6073:
5803:
5788:
2716:
activity, contributing to conflicting results when examining
Alzheimer's survival rates. Of note, the deletion of
7962:
7456:
7142:
6058:
6043:
2880:
2859:
2751:
carriers (VV and MV) show a 13% decreased risk with respect to developing
Alzheimer's compared to the methionine
2048:
663:
2063:- terminal ends are removed posttranslationally, resulting in a mature length of 208 amino acids. For human and
7601:
7137:
5893:
5878:
5863:
5848:
5833:
5818:
4984:
Castilla J, Hetz C, Soto C (June 2004). "Molecular mechanisms of neurotoxicity of pathological prion protein".
1935:
1563:
6242:
6193:
8098:
7570:
7565:
7510:
7244:
6693:
2768:
2507:
1947:
585:
560:
1544:
7792:
7515:
5968:
5953:
3666:
2165:
502:
2704:
when injected with Aβ oligomers. In mammals, the full functional significance of PRNP remains unclear, as
7110:
2817:
2014:
5594:
Americo TA, Chiarini LB, Linden R (June 2007). "Signaling induced by hop/STI-1 depends on endocytosis".
3817:"Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains"
3485:"Prion protein prevents heavy metals overloading of cells and thus protects them against their toxicity"
7822:
6247:
5998:
2209:
2103:
1865:
699:
598:
5631:"Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection"
5185:"Brain disease 'resistance gene' evolves in Papua New Guinea community; could offer insights into CJD"
6688:
5716:
5545:
Richt JA, Kasinathan P, Hamir AN, Castilla J, Sathiyaseelan T, Vargas F, et al. (January 2007).
5106:
Montagna P, Gambetti P, Cortelli P, Lugaresi E (March 2003). "Familial and sporadic fatal insomnia".
3387:"Pseudoknots in prion protein mRNAs confirmed by comparative sequence analysis and pattern searching"
2656:
or a site-specific relational significance. In the case of direct injection of Aβ oligomers into the
2470:
2033:
1740:
1736:
1732:
692:
591:
2248:
The propagation of PrP is a topic of great interest, as its accumulation is a pathological cause of
489:
7872:
6767:
5696:
5690:
3346:
2712:
varies between
Alzheimer's mouse lines, as hAPPJ20 mice and TgCRND8 mice show a slight increase in
1765:
1714:
1710:
1706:
1702:
1674:
1653:
1643:
1639:
1635:
510:
4329:"Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein"
2114:
The mechanism for conformational conversion to the scrapie isoform is speculated to be an elusive
1744:
1728:
493:, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
7836:
6028:
6013:
5686:
5184:
4193:"Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene"
2780:
2542:
2310:
2204:
nitrogens from the 2nd and 3rd glycines in the repeat. The ability to bind copper is, therefore,
1951:
1939:
4191:
Medori R, Tritschler HJ, LeBlanc A, Villare F, Manetto V, Chen HY, et al. (February 1992).
1769:
1724:
1698:
1678:
1631:
1627:
7179:
7174:
7169:
7159:
6466:
6394:
3341:
2796:
2621:
2388:
2362:
2263:
4327:
Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, et al. (February 2010).
2652:
deficits. This would suggest either an unequal relation between PRNP and Aβ oligomer-mediated
2640:
in animals has yielded several conflicting findings. When Aβ oligomers were injected into the
6523:
6441:
5629:
Zanata SM, Lopes MH, Mercadante AF, Hajj GN, Chiarini LB, Nomizo R, et al. (July 2002).
5370:"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers"
4880:"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers"
4429:
Shorter J, Lindquist S (June 2005). "Prions as adaptive conduits of memory and inheritance".
2228:
PrP is a conformational isoform of PrP, but this orientation tends to accumulate in compact,
1989:
574:
6127:: Ovine recombinant PrP(114-234), ARR variant in complex with the VRQ14 Fab fragment (IgG2a)
4472:
Papassotiropoulos A, Wollmer MA, Aguzzi A, Hock C, Nitsch RM, de
Quervain DJ (August 2005).
8269:
7760:
7473:
6112:: Ovine recombinant PrP(114-234), VRQ variant in complex with the Fab of the VRQ14 antibody
6097:: Ovine recombinant PrP(114-234), ARQ variant in complex with the Fab of the VRQ14 antibody
5709:
5381:
5149:
Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, et al. (November 2009).
4891:
4340:
3980:
3881:
3828:
3771:
3681:
3333:
3243:
3032:
2977:
2755:(MM). However, the protective effects of variant V carriers have been found exclusively in
2736:
2669:
2648:
deletion did not offer protection, only anti-PrP antibodies prevented long-term memory and
2478:
2435:(TSE), neurodegenerative diseases caused by prions, could stem from the tolerance for PrP.
2416:
2141:
5270:
Laurén J (2014). "Cellular prion protein as a therapeutic target in
Alzheimer's disease".
530:
8:
7787:
7606:
3923:
BĂĽeler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, Weissmann C (July 1993).
2665:
2462:
2233:
1974:
5385:
4895:
4344:
3885:
3832:
3775:
3685:
3667:"NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231)"
3337:
3247:
3036:
2981:
2964:
Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, et al. (October 1986).
7194:
6928:
5571:
5546:
5501:
5454:
5402:
5369:
5340:
5315:
5230:
5205:
5131:
5088:
5044:
4961:
4936:
4912:
4879:
4860:
4811:
4762:
4714:
4704:
4687:
4668:
4625:
4582:
4539:
4454:
4411:
4363:
4328:
4309:
4265:
4217:
4192:
4138:
4095:
3905:
3849:
3816:
3792:
3759:
3705:
3647:
3604:
3555:
3367:
3266:
3231:
3168:
2641:
2237:
1908:
534:
5992:: Crystal structure of the human prion protein reveals a mechanism for oligomerization
5655:
5630:
5119:
4253:
4169:
3693:
3622:
Ross CA, Poirier MA (July 2004). "Protein aggregation and neurodegenerative disease".
3000:
2965:
2398:
Some research indicates PrP involvement in neuronal development, differentiation, and
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
5660:
5611:
5576:
5493:
5446:
5407:
5345:
5287:
5235:
5172:
5123:
5080:
5036:
5001:
4966:
4952:
4917:
4852:
4847:
4830:
4803:
4754:
4750:
4719:
4686:
Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, et al. (October 1999).
4660:
4617:
4574:
4531:
4495:
4446:
4403:
4399:
4368:
4301:
4257:
4222:
4173:
4130:
4087:
4052:
4011:
3984:
3946:
3941:
3924:
3897:
3854:
3815:
Hoyt F, Standke HG, Artikis E, Schwartz CL, Hansen B, Li K, et al. (July 2022).
3797:
3758:
Manka SW, Zhang W, Wenborn A, Betts J, Joiner S, Saibil HR, et al. (July 2022).
3740:
3697:
3651:
3639:
3596:
3591:
3574:
3547:
3542:
3525:
3506:
3462:
3416:
3411:
3386:
3359:
3306:
3271:
3212:
3160:
3125:
3084:
3080:
3048:
3005:
2946:
2653:
2326:
2249:
2232:-resistant aggregates within neural tissue. The abnormal PrP isoform has a different
2213:
2152:
The precise function of PrP is not yet known. It may play a role in the transport of
1912:
482:
54:
5505:
5458:
5135:
5092:
5048:
4864:
4766:
4672:
4629:
4586:
4543:
4415:
4269:
4142:
4099:
3709:
3608:
3559:
3371:
3172:
2628:
are composed of smaller Aβ plaques, and are the most damaging to the integrity of a
7967:
7700:
7621:
7184:
6377:
6303:
5650:
5642:
5603:
5566:
5558:
5485:
5438:
5397:
5389:
5335:
5327:
5279:
5225:
5217:
5162:
5115:
5072:
5028:
4993:
4956:
4948:
4907:
4899:
4842:
4815:
4793:
4746:
4709:
4699:
4652:
4609:
4566:
4523:
4485:
4458:
4438:
4395:
4358:
4348:
4313:
4293:
4249:
4212:
4204:
4165:
4122:
4079:
4042:
3976:
3936:
3909:
3889:
3844:
3836:
3787:
3779:
3732:
3689:
3631:
3586:
3537:
3496:
3454:
3406:
3398:
3351:
3298:
3261:
3251:
3202:
3152:
3115:
3076:
3040:
2995:
2985:
2938:
2764:
2685:
2649:
2338:
2330:
2306:
2185:
repeats with sequence PHGGGWGQ (though the first repeat has the slightly modified,
2137:
2099:
2006:
779:
710:
654:
609:
5752:: PRION PROTEIN DOMAIN PRP(121-231) FROM MOUSE, NMR, 2 MINIMIZED AVERAGE STRUCTURE
5681:
2588:
In addition, some prion diseases can be transmitted from external sources of PrP.
514:
8027:
6563:
6558:
6481:
4798:
4781:
4656:
3736:
3189:
Zomosa-Signoret V, Arnaud JD, Fontes P, Alvarez-Martinez MT, Liautard JP (2008).
2966:"Assignment of the human and mouse prion protein genes to homologous chromosomes"
2701:
2060:
2029:
754:
538:
4208:
3120:
3103:
2916:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2898:
National Center for
Biotechnology Information, U.S. National Library of Medicine
7812:
7234:
6745:
6548:
5607:
4333:
Proceedings of the National Academy of Sciences of the United States of America
3840:
3783:
3458:
3236:
Proceedings of the National Academy of Sciences of the United States of America
2970:
Proceedings of the National Academy of Sciences of the United States of America
2772:
2756:
2709:
2681:
2604:
2582:
2380:
2292:
2266:
at sites 136, 154, and 171 are associated with varying susceptibility to ovine
2190:
2064:
2052:
1959:
1873:
855:
5489:
5442:
5368:
Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (February 2009).
5331:
5204:
Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, et al. (2009).
5151:"A novel protective prion protein variant that colocalizes with kuru exposure"
5032:
4878:
Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (February 2009).
4527:
4297:
4126:
4083:
3967:
Aguzzi A, Baumann F, Bremer J (2008). "The prion's elusive reason for being".
8253:
7782:
7239:
6330:
4997:
4599:
3207:
3190:
2824:
2673:
2633:
2546:
2511:
2500:
2474:
2354:
2178:
2161:
2091:
2087:
179 of the second helix and Cys214 of the third helix (human PrP numbering).
2068:
2037:
1978:
973:
944:
937:
4353:
3573:
Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G (December 2005).
3355:
3256:
3230:
Damberger FF, Christen B, PĂ©rez DR, Hornemann S, WĂĽthrich K (October 2011).
3044:
2990:
915:
793:
8138:
7446:
7436:
6967:
6933:
5664:
5646:
5615:
5580:
5497:
5450:
5411:
5349:
5291:
5239:
5176:
5127:
5084:
5076:
5040:
5005:
4970:
4921:
4856:
4807:
4723:
4664:
4621:
4535:
4499:
4450:
4407:
4372:
4305:
4261:
4177:
4134:
4056:
4015:
3988:
3901:
3858:
3801:
3744:
3643:
3600:
3551:
3510:
3501:
3484:
3466:
3420:
3402:
3363:
3302:
3275:
3216:
3188:
3164:
3129:
2942:
2747:(rs1799990) is most closely associated with Alzheimer's disease. Variant V
2617:
2257:
2021:
1900:
772:
551:
5167:
5150:
4758:
4578:
4226:
4091:
4047:
4030:
3950:
3701:
3310:
3088:
3052:
3009:
2950:
1833:
1828:
8148:
7797:
7575:
7550:
7249:
6871:
6797:
6271:
4570:
4490:
4473:
2821:
2697:
2689:
2657:
2412:
2392:
2384:
2242:
2010:
1608:
1589:
5393:
5221:
4903:
3893:
3526:"Antioxidant activity related to copper binding of native prion protein"
3156:
8078:
7802:
7483:
7224:
7100:
6733:
6728:
6723:
6578:
6362:
5283:
3665:
Riek R, Hornemann S, Wider G, Glockshuber R, WĂĽthrich K (August 1997).
2752:
2729:
2721:
2595:– fatal neurodegenerative disease in sheep, not transmissible to humans
2567:
2554:
2550:
2457:
2296:
2284:
2217:
2197:
2169:
2095:
2072:
2044:
2017:
2009:. The human protein structure consists of a globular domain with three
1399:
regulation of intracellular calcium activated chloride channel activity
671:
568:
518:
6157:: Solution structure of the sheep prion protein with polymorphism H168
4613:
2928:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
315:
311:
307:
303:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
7917:
7912:
7907:
7897:
7892:
7887:
7882:
6142:: THE CRYSTAL STRUCTURE OF THE GLOBULAR DOMAIN OF SHEEP PRION PROTEIN
2713:
2424:
2420:
2194:
2189:-deficient sequence PQGGGGWGQ). This is thought to generate a copper-
2186:
2129:
2080:
1993:
1463:
738:
725:
637:
624:
526:
5562:
4688:"Evidence of presynaptic location and function of the prion protein"
4442:
2791:
in cases of ambiguously diagnosed dementia, as the various forms of
2361:
substitution have been linked to earlier cognitive decline. Several
2345:(LN) is pivotal in memory processing and is likely modulated by the
8223:
8123:
7937:
7922:
7125:
7120:
7028:
6718:
5018:
3635:
2792:
2625:
2229:
2084:
1888:
1880:
1817:
5697:
Susan Lindquist's Seminar: "The Surprising World of Prion Biology"
4471:
4282:
2835:
organizing protein; also called STI1 (Stress-induced protein 1)).
2779:
at least in part contributed to three separate patients' atypical
2632:. The precise mechanism of soluble Aβ oligomers directly inducing
1409:
negative regulation of amyloid precursor protein catabolic process
8173:
8168:
8163:
8063:
7877:
7867:
7694:
7673:
7668:
7636:
7441:
7361:
7356:
7351:
7346:
7341:
7259:
6952:
6792:
6787:
6782:
6777:
6772:
6243:
2592:
2562:
progression of neurodegeneration and is the proposed cause. Some
2537:
2533:
2399:
2346:
2342:
2267:
2182:
2157:
2076:
1919:
1869:
1575:
1530:
1448:
1444:
5105:
3572:
3065:
1249:
negative regulation of DNA-binding transcription factor activity
506:
8113:
8073:
8058:
8042:
8037:
8017:
8012:
7947:
7755:
7725:
7689:
7680:
7493:
7461:
7325:
7320:
7290:
7269:
7229:
7189:
7055:
7033:
6992:
6916:
6911:
6906:
6901:
6896:
6891:
6760:
6755:
6750:
6698:
6683:
6553:
6543:
6506:
6501:
6419:
6414:
3871:
3229:
2748:
2733:
2629:
2578:
2519:
2515:
2428:
2358:
2334:
2172:
2133:
2121:
2115:
1801:
1485:
953:
5701:
4239:
4190:
3323:
1414:
positive regulation of protein localization to plasma membrane
8238:
8213:
8133:
8128:
8118:
8108:
8093:
8088:
8083:
8068:
8022:
8007:
7972:
7957:
7952:
7942:
7862:
7857:
7852:
7831:
7827:
7817:
7730:
7631:
7626:
7585:
7535:
7530:
7525:
7520:
7505:
7498:
7478:
7466:
7409:
7404:
7399:
7389:
7384:
7377:
7315:
7305:
7300:
7295:
7285:
7264:
7254:
7219:
7214:
7209:
7204:
7199:
7154:
7149:
7115:
7080:
7075:
7070:
7060:
7048:
7043:
7023:
7018:
7013:
7008:
6962:
6854:
6849:
6668:
6652:
6645:
6640:
6635:
6630:
6625:
6620:
6595:
6573:
6568:
6461:
6387:
6382:
6372:
4937:"The role of the cellular prion protein in the immune system"
4831:"Common molecular mechanisms in explicit and implicit memory"
4326:
3664:
2832:
2828:
2760:
2740:
2581:
that codes for a PRNP variant, G127V, provides resistance to
2529:
2201:
2056:
1916:
1339:
calcium-mediated signaling using intracellular calcium source
20:
5544:
4642:
2696:
codes for the enzyme Fyn, FYN-knockout mice display neither
2668:. It was further found that Aβ-oligomers bind to PrP at the
2620:(Aβ) oligomers, which are canonically implicated in causing
2616:
PrP protein is one of several cellular receptors of soluble
1992:
between the end (terminus) of the arm and position 13, from
8233:
8228:
8218:
8208:
8203:
8198:
8153:
8143:
8103:
8032:
8002:
7997:
7992:
7987:
7982:
7977:
7932:
7902:
7807:
7775:
7770:
7750:
7740:
7735:
7720:
7715:
7616:
7611:
7580:
7560:
7555:
7545:
7540:
7419:
7372:
7332:
6987:
6982:
6977:
6972:
6957:
6948:
6943:
6938:
6923:
6881:
6876:
6866:
6861:
6844:
6839:
6834:
6829:
6824:
6819:
6814:
6809:
6804:
6740:
6713:
6708:
6703:
6678:
6673:
6610:
6605:
6600:
6590:
6585:
6538:
6533:
6528:
6518:
6513:
6496:
6491:
6486:
6476:
6471:
6456:
6451:
6446:
6436:
6431:
6426:
6409:
6404:
6399:
6350:
6318:
6313:
6308:
6291:
6286:
6281:
6276:
5474:
4069:
3444:
3385:
Barrette I, Poisson G, Gendron P, Major F (February 2001).
3384:
2383:. In this role, the protein could serve as either a copper
2337:, this is attributable to Doppel gene expression. However,
2300:
2125:
1943:
1857:
37:
5367:
4877:
4474:"The prion gene is associated with human long-term memory"
4155:
3814:
3288:
2036:(GPI) membrane anchor at the COOH-terminal tethers PrP to
7745:
6357:
6345:
6340:
6335:
6325:
6298:
6266:
5628:
4031:"PrP knock-out and PrP transgenic mice in prion research"
3922:
3478:
3476:
3104:"Shattuck lecture--neurodegenerative diseases and prions"
2693:
2692:, another protein implicated in Alzheimer's. As the gene
2677:
2153:
1229:
negative regulation of calcineurin-NFAT signaling cascade
5148:
4385:
4112:
2963:
2688:, forming a complex with Fyn and excessively activating
2102:), which is thought to be involved in regulation of PrP
1359:
positive regulation of peptidyl-tyrosine phosphorylation
1254:
negative regulation of T cell receptor signaling pathway
762:
4736:
4556:
3722:
3143:
Weissmann C (November 2004). "The state of the prion".
3022:
2783:
within the same family, suggesting a new phenotype for
2333:
consolidation deficits have been demonstrated. As with
2205:
1429:
regulation of calcium ion import across plasma membrane
1364:
positive regulation of protein tyrosine kinase activity
3760:"2.7 Ă… cryo-EM structure of ex vivo RML prion fibrils"
3757:
3473:
1876:
but occurs in many other tissues throughout the body.
1379:
negative regulation of long-term synaptic potentiation
1183:
anchored component of external side of plasma membrane
5593:
5203:
4685:
4512:
3482:
1264:
negative regulation of activated T cell proliferation
927:
5917:: HUMAN PRION PROTEIN (MUTANT E200K) FRAGMENT 90-231
5061:
4934:
4002:
Atkinson M (October 2001). "National scrapie plan".
2484:
2325:
While null mice exhibit normal learning ability and
2079:
PrP has glycosylation sites as Asn180 and Asn196. A
1369:
positive regulation of protein targeting to membrane
5596:
Biochemical and Biophysical Research Communications
3966:
3069:
Biochemical and Biophysical Research Communications
2499:gene have been identified in people with inherited
2313:is thought to be the result of a point mutation in
1309:
regulation of potassium ion transmembrane transport
5932:: HUMAN PRION PROTEIN MUTANT E200K FRAGMENT 90-231
5470:
5468:
4935:Isaacs JD, Jackson GS, Altmann DM (October 2006).
3232:"Cellular prion protein conformation and function"
3191:"Physiological role of the cellular prion protein"
2872:
2870:
2868:
2851:
2849:
2847:
1404:negative regulation of dendritic spine maintenance
1384:regulation of glutamate receptor signaling pathway
1219:negative regulation of interferon-gamma production
4828:
4028:
3523:
2147:
709:
608:
8251:
4983:
4428:
2438:
1294:negative regulation of interleukin-17 production
5465:
2865:
2844:
2684:. Soluble Aβ oligomers also bind to PrP at the
1354:regulation of peptidyl-tyrosine phosphorylation
1349:positive regulation of neuron apoptotic process
1304:negative regulation of interleukin-2 production
5363:
5361:
5359:
5265:
5263:
5261:
5259:
5257:
5255:
5253:
5251:
5249:
4779:
3524:Brown DR, Clive C, Haswell SJ (January 2001).
2877:GRCm38: Ensembl release 89: ENSMUSG00000079037
2379:function casts PrP as a copper buffer for the
1214:negative regulation of protein phosphorylation
1057:type 8 metabotropic glutamate receptor binding
1052:type 5 metabotropic glutamate receptor binding
6228:
5717:
5427:
4780:Bailey CH, Kandel ER, Si K (September 2004).
3925:"Mice devoid of PrP are resistant to scrapie"
3483:Prčina M, Kontseková E, Novák M (June 2015).
1394:negative regulation of amyloid-beta formation
5622:
5587:
5547:"Production of cattle lacking prion protein"
5309:
5307:
5305:
5303:
5301:
5197:
5099:
5055:
5012:
4977:
4928:
4871:
4822:
4773:
4679:
4636:
4593:
4506:
4465:
4422:
4379:
4320:
4276:
4233:
4149:
4106:
4022:
3865:
3615:
3517:
3317:
3223:
3136:
2767:, to compound risk for both Alzheimer's and
1907:version PrP is associated with a variety of
5356:
5246:
4829:Barco A, Bailey CH, Kandel ER (June 2006).
4730:
4550:
4184:
4063:
3916:
3621:
3282:
3095:
2856:GRCh38: Ensembl release 89: ENSG00000171867
2160:. PrP attaches to the outer surface of the
16:Protein involved in multiple prion diseases
6235:
6221:
5724:
5710:
5521:"Scientists Announce Mad Cow Breakthrough"
5423:
5421:
3962:
3960:
3440:
3438:
3436:
3434:
3432:
3430:
3184:
3182:
3059:
3016:
2957:
2922:
2223:
6252:list of human clusters of differentiation
6187:: Mouse Prion Protein with mutation N174T
5947:: HUMAN PRION PROTEIN 121-230 M166C/E221C
5689:at the U.S. National Library of Medicine
5654:
5570:
5401:
5339:
5298:
5229:
5166:
4960:
4911:
4846:
4797:
4713:
4703:
4489:
4362:
4352:
4216:
4046:
3940:
3848:
3791:
3590:
3541:
3500:
3410:
3345:
3265:
3255:
3206:
3142:
3119:
2999:
2989:
2636:is unknown, and experimental deletion of
2433:transmissible spongiform encephalopathies
1344:negative regulation of catalytic activity
1324:negative regulation of protein processing
5320:Intractable & Rare Diseases Research
4158:Brain Research. Molecular Brain Research
4001:
3101:
1988:gene is located on the short (p) arm of
1973:
1239:negative regulation of apoptotic process
1193:intracellular membrane-bounded organelle
5782:: BOVINE PRION PROTEIN FRAGMENT 121-230
5767:: BOVINE PRION PROTEIN FRAGMENT 121-230
5418:
5316:"Alzheimer's disease and prion protein"
5313:
3957:
3427:
3179:
2785:Gerstmann–Sträussler–Scheinker syndrome
2526:Gerstmann–Sträussler–Scheinker syndrome
2491:Transmissible spongiform encephalopathy
2373:
2291:As the null mice age, a marked loss of
1956:Gerstmann–Sträussler–Scheinker syndrome
8252:
6172:: mouse prion protein fragment 121-231
6082:: HUMAN PRION PROTEIN FRAGMENT 121-230
5812:: BOVINE PRION PROTEIN RESIDUES 23-230
5797:: BOVINE PRION PROTEIN RESIDUES 23-230
5269:
3981:10.1146/annurev.neuro.31.060407.125620
2720:in both APPswe and SEN1dE9, two other
2611:
2456:Varying expression of PrP through the
1853:) is encoded in the human body by the
6216:
6067:: HUMAN PRION PROTEIN FRAGMENT 90-230
6052:: HUMAN PRION PROTEIN FRAGMENT 90-230
5705:
5518:
5206:"A systems approach to prion disease"
2787:. The same study proposed sequencing
2566:mutations lead to a change in single
1334:activation of protein kinase activity
714:
675:
670:
613:
572:
567:
5431:Journal of the Neurological Sciences
4941:Clinical and Experimental Immunology
4388:The European Journal of Neuroscience
2193:via nitrogen atoms in the histidine
1899:(scrapie) and an isoform located in
5902:: HUMAN PRION PROTEIN VARIANT R220K
5887:: HUMAN PRION PROTEIN VARIANT R220K
5872:: HUMAN PRION PROTEIN VARIANT S170N
5857:: HUMAN PRION PROTEIN VARIANT S170N
5842:: HUMAN PRION PROTEIN VARIANT M166V
5827:: HUMAN PRION PROTEIN VARIANT M166V
5191:(Press release). November 21, 2009.
5155:The New England Journal of Medicine
4197:The New England Journal of Medicine
4072:Cellular and Molecular Neurobiology
3108:The New England Journal of Medicine
2043:The primary sequence of PrP is 253
1389:positive regulation of neuron death
13:
6202:: Ovine Prion Protein Variant R168
4705:10.1523/JNEUROSCI.19-20-08866.1999
2769:sporadic Creutzfeldt–Jakob disease
2212:shows copper binding results in a
2071:sites exist on helices 2 and 3 at
1996:4,615,068 to base pair 4,630,233.
1879:The protein can exist in multiple
1259:regulation of protein localization
1067:protein-containing complex binding
14:
8281:
5674:
2644:of a mouse model of Alzheimer's,
2485:Diseases caused by PrP misfolding
2278:
2109:
1964:variant Creutzfeldt–Jakob disease
1932:transmissible mink encephalopathy
1424:cellular response to amyloid-beta
1319:positive regulation of cell death
992:transmembrane transporter binding
6192:
6177:
6162:
6147:
6132:
6117:
6102:
6087:
6072:
6057:
6042:
6027:
6012:
5997:
5982:
5967:
5952:
5937:
5922:
5907:
5892:
5877:
5862:
5847:
5832:
5817:
5802:
5787:
5772:
5757:
5742:
5065:Journal of Clinical Neuroscience
4953:10.1111/j.1365-2249.2006.03194.x
4848:10.1111/j.1471-4159.2006.03870.x
4400:10.1111/j.1460-9568.2006.05156.x
4029:Weissmann C, Flechsig E (2003).
3592:10.1111/j.1471-4159.2005.03469.x
3543:10.1046/j.1471-4159.2001.00009.x
2672:, indirectly overactivating the
2599:Bovine spongiform encephalopathy
2415:; also, it has been detected in
2405:
1928:feline spongiform encephalopathy
1924:bovine spongiform encephalopathy
943:
936:
698:
691:
685:
662:
597:
590:
584:
559:
36:
5977:: HUMAN PRION PROTEIN AT PH 7.0
5962:: HUMAN PRION PROTEIN AT PH 7.0
5731:
5538:
5512:
5142:
3995:
3808:
3751:
3716:
3658:
3566:
3378:
2811:
2503:, which include the following:
2049:post-translational modification
1279:cellular response to copper ion
1274:cellular copper ion homeostasis
1158:extrinsic component of membrane
5272:Journal of Alzheimer's Disease
2904:
2886:
2495:More than 20 mutations in the
1936:exotic ungulate encephalopathy
1143:anchored component of membrane
1108:integral component of membrane
954:More reference expression data
916:More reference expression data
882:Region I of hippocampus proper
808:Region I of hippocampus proper
1:
5120:10.1016/S1474-4422(03)00323-5
4254:10.1016/S0306-4522(99)00092-5
4170:10.1016/S0169-328X(99)00193-X
3969:Annual Review of Neuroscience
3694:10.1016/S0014-5793(97)00920-4
2838:
2573:Several other changes in the
2439:Muscles, liver, and pituitary
2148:PrP (normal cellular) isoform
1915:diseases such as in animals:
1434:neuron projection maintenance
1002:ATP-dependent protein binding
683:
582:
8260:Genes on human chromosome 20
4799:10.1016/j.neuron.2004.09.017
4751:10.1016/0304-3940(89)90565-X
4657:10.1016/j.neulet.2005.05.067
3942:10.1016/0092-8674(93)90360-3
3737:10.1016/j.molcel.2021.08.011
3291:Journal of Molecular Biology
3145:Nature Reviews. Microbiology
3081:10.1016/0006-291X(86)90796-5
2557:is present at amino acid 129
2522:is present at amino acid 129
2166:glycosylphosphatidylinositol
1999:
1895:such as the disease-causing
1244:response to oxidative stress
1093:mitochondrial outer membrane
836:Epithelium of choroid plexus
7:
8265:Clusters of differentiation
6248:clusters of differentiation
6007:: HUMAN PRION PROTEIN 61-84
4692:The Journal of Neuroscience
4209:10.1056/NEJM199202133260704
3121:10.1056/NEJM200105173442006
2820:exists between PrP and the
2802:
2451:
2273:
1891:-resistant form designated
1872:is most predominant in the
1374:dendritic spine maintenance
1299:protein homooligomerization
1062:signaling receptor activity
866:nucleus of stria terminalis
10:
8286:
5608:10.1016/j.bbrc.2007.04.202
5519:Weiss R (1 January 2007).
5314:Zhou J, Liu B (May 2013).
4986:Current Molecular Medicine
4115:Behavioural Brain Research
3841:10.1038/s41467-022-30458-6
3784:10.1038/s41467-022-30457-7
3459:10.1152/physrev.00007.2007
2488:
1866:cluster of differentiation
812:retinal pigment epithelium
18:
8051:
7845:
7594:
7278:
7001:
6661:
6259:
5737:
5490:10.1007/s10072-008-1025-z
5443:10.1016/j.jns.2013.01.020
5332:10.5582/irdr.2013.v2.2.35
5210:Molecular Systems Biology
5033:10.1007/s00415-002-0896-9
4835:Journal of Neurochemistry
4528:10.1007/s00415-003-1057-5
4298:10.1016/j.nbd.2005.01.001
4127:10.1016/j.bbr.2005.02.003
3579:Journal of Neurochemistry
3530:Journal of Neurochemistry
2912:"Mouse PubMed Reference:"
2894:"Human PubMed Reference:"
2795:can prove challenging to
2702:dendritic spine shrinkage
2508:Creutzfeldt–Jakob disease
2479:extracellular scaffolding
2320:
2309:is altered in null mice.
2034:glycophosphatidylinositol
1948:Creutzfeldt–Jakob disease
1832:
1827:
1823:
1816:
1800:
1794:Chr 2: 131.75 – 131.78 Mb
1781:
1762:
1758:
1721:
1697:
1690:
1671:
1667:
1650:
1626:
1619:
1606:
1602:
1587:
1583:
1574:
1561:
1557:
1542:
1538:
1529:
1516:
1512:
1497:
1493:
1484:
1469:
1462:
1458:
1442:
1047:glycosaminoglycan binding
1022:identical protein binding
972:
968:
951:
935:
926:
913:
862:
853:
800:
791:
761:
753:
749:
732:
719:
682:
661:
652:
648:
631:
618:
581:
558:
549:
545:
500:
497:
487:
480:
475:
80:
75:
58:
53:
48:
44:
35:
30:
5691:Medical Subject Headings
4998:10.2174/1566524043360654
4478:Human Molecular Genetics
4431:Nature Reviews. Genetics
4035:British Medical Bulletin
3102:Prusiner SB (May 2001).
1926:(BSE, mad cow disease),
1868:230). Expression of the
1419:response to amyloid-beta
902:anterior amygdaloid area
19:Not to be confused with
4354:10.1073/pnas.0911829107
4286:Neurobiology of Disease
4084:10.1023/A:1020234321879
3356:10.1126/science.1110837
3257:10.1073/pnas.1106325108
3045:10.1126/science.3014653
2991:10.1073/pnas.83.19.7358
2797:differentially diagnose
2781:frontotemporal dementia
2543:fatal familial insomnia
2357:patients with a single
2311:Fatal familial insomnia
2241:extremely resistant to
1969:
1952:fatal familial insomnia
1940:chronic wasting disease
1329:protein destabilization
1224:response to cadmium ion
5077:10.1054/jocn.2001.0919
3502:10.4149/av_2015_02_179
3391:Nucleic Acids Research
3303:10.1006/jmbi.1994.0030
3208:10.1051/vetres:2007048
2943:10.1089/dna.1986.5.315
2528:– usually a change in
2477:supports claims of an
2389:long-term potentiation
1981:
1234:response to copper ion
6037:: HUMAN PRION PROTEIN
6022:: HUMAN PRION PROTEIN
5478:Neurological Sciences
5168:10.1056/NEJMoa0809716
5108:The Lancet. Neurology
4004:The Veterinary Record
3821:Nature Communications
3764:Nature Communications
3447:Physiological Reviews
2680:enzyme, resulting in
2224:PrP (scrapie) isoform
1977:
1787:Chr 20: 4.69 – 4.7 Mb
1148:extracellular exosome
1133:endoplasmic reticulum
575:Chromosome 20 (human)
5647:10.1093/emboj/cdf325
5551:Nature Biotechnology
5021:Journal of Neurology
4739:Neuroscience Letters
4645:Neuroscience Letters
4571:10.1212/wnl.51.3.734
4516:Journal of Neurology
3731:(21): 4540–4551.e6.
3630:(7 Suppl): S10–S17.
3403:10.1093/nar/29.3.753
2670:postsynaptic density
2549:-178 is replaced by
2514:-200 is replaced by
2417:natural killer cells
2374:Neurons and synapses
2142:heavy metal toxicity
2083:bond exists between
2007:amino acid sequences
1942:(CWD) which affects
1168:postsynaptic density
1037:amyloid-beta binding
816:orbitofrontal cortex
716:2 F2|2 64.07 cM
677:Chromosome 2 (mouse)
76:List of PDB id codes
49:Available structures
5687:PRNP+protein,+human
5680:PRNP (PrP) gene at
5525:The Washington Post
5394:10.1038/nature07761
5386:2009Natur.457.1128L
5380:(7233): 1128–1132.
5222:10.1038/msb.2009.10
4904:10.1038/nature07761
4896:2009Natur.457.1128L
4890:(7233): 1128–1132.
4602:Annals of Neurology
4345:2010PNAS..107.2295B
4048:10.1093/bmb/66.1.43
3894:10.1038/nature09768
3886:2011Natur.470..540S
3833:2022NatCo..13.4005H
3776:2022NatCo..13.4004M
3686:1997FEBSL.413..282R
3338:2005Sci...308.1435C
3332:(5727): 1435–1439.
3248:2011PNAS..10817308D
3242:(42): 17308–17313.
3195:Veterinary Research
3157:10.1038/nrmicro1025
3037:1986Sci...233..364L
2982:1986PNAS...83.7358S
2666:synaptic plasticity
2642:cerebral ventricles
2622:Alzheimer's disease
2612:Alzheimer's disease
2463:signal transduction
2104:protein translation
1909:cognitive disorders
1847:major prion protein
1077:cuprous ion binding
997:microtubule binding
828:trigeminal ganglion
5284:10.3233/JAD-130950
4491:10.1093/hmg/ddi228
2238:tertiary structure
2032:-terminal tail. A
2028:tail, and a short
1982:
1564:ENSMUSG00000079037
1269:learning or memory
1207:Biological process
1086:Cellular component
1072:cupric ion binding
1027:copper ion binding
980:Molecular function
8247:
8246:
6210:
6209:
5641:(13): 3307–3316.
5161:(21): 2056–2065.
5027:(11): 1567–1582.
4698:(20): 8866–8875.
4614:10.1002/ana.10658
4484:(15): 2241–2246.
4394:(11): 3255–3264.
3880:(7335): 540–542.
3114:(20): 1516–1526.
3031:(4761): 364–367.
2976:(19): 7358–7362.
2654:neurodegeneration
2327:short-term memory
2250:neurodegeneration
2200:and deprotonated
2013:and a two-strand
1946:; and in humans:
1913:neurodegenerative
1843:
1842:
1839:
1838:
1812:
1811:
1777:
1776:
1752:
1751:
1686:
1685:
1661:
1660:
1615:
1614:
1596:
1595:
1570:
1569:
1551:
1550:
1525:
1524:
1506:
1505:
1454:
1453:
1007:metal ion binding
987:chaperone binding
964:
963:
960:
959:
922:
921:
909:
908:
878:perirhinal cortex
874:entorhinal cortex
847:
846:
745:
744:
644:
643:
471:
470:
467:
466:
59:Ortholog search:
8277:
6237:
6230:
6223:
6214:
6213:
6196:
6181:
6166:
6151:
6136:
6121:
6106:
6091:
6076:
6061:
6046:
6031:
6016:
6001:
5986:
5971:
5956:
5941:
5926:
5911:
5896:
5881:
5866:
5851:
5836:
5821:
5806:
5791:
5776:
5761:
5746:
5726:
5719:
5712:
5703:
5702:
5669:
5668:
5658:
5635:The EMBO Journal
5626:
5620:
5619:
5591:
5585:
5584:
5574:
5542:
5536:
5535:
5533:
5531:
5516:
5510:
5509:
5472:
5463:
5462:
5425:
5416:
5415:
5405:
5365:
5354:
5353:
5343:
5311:
5296:
5295:
5267:
5244:
5243:
5233:
5201:
5195:
5192:
5180:
5170:
5146:
5140:
5139:
5103:
5097:
5096:
5059:
5053:
5052:
5016:
5010:
5009:
4981:
4975:
4974:
4964:
4932:
4926:
4925:
4915:
4875:
4869:
4868:
4850:
4841:(6): 1520–1533.
4826:
4820:
4819:
4801:
4777:
4771:
4770:
4734:
4728:
4727:
4717:
4707:
4683:
4677:
4676:
4640:
4634:
4633:
4597:
4591:
4590:
4554:
4548:
4547:
4510:
4504:
4503:
4493:
4469:
4463:
4462:
4426:
4420:
4419:
4383:
4377:
4376:
4366:
4356:
4339:(5): 2295–2300.
4324:
4318:
4317:
4292:(1–2): 255–265.
4280:
4274:
4273:
4248:(4): 1201–1204.
4237:
4231:
4230:
4220:
4188:
4182:
4181:
4153:
4147:
4146:
4110:
4104:
4103:
4067:
4061:
4060:
4050:
4026:
4020:
4019:
3999:
3993:
3992:
3964:
3955:
3954:
3944:
3935:(7): 1339–1347.
3920:
3914:
3913:
3869:
3863:
3862:
3852:
3812:
3806:
3805:
3795:
3755:
3749:
3748:
3720:
3714:
3713:
3671:
3662:
3656:
3655:
3619:
3613:
3612:
3594:
3585:(5): 1373–1386.
3570:
3564:
3563:
3545:
3521:
3515:
3514:
3504:
3480:
3471:
3470:
3442:
3425:
3424:
3414:
3382:
3376:
3375:
3349:
3321:
3315:
3314:
3286:
3280:
3279:
3269:
3259:
3227:
3221:
3220:
3210:
3186:
3177:
3176:
3140:
3134:
3133:
3123:
3099:
3093:
3092:
3063:
3057:
3056:
3020:
3014:
3013:
3003:
2993:
2961:
2955:
2954:
2926:
2920:
2919:
2908:
2902:
2901:
2890:
2884:
2874:
2863:
2853:
2775:on codon 102 of
2686:dendritic spines
2650:spatial learning
2349:PKA and ERK1/2.
2339:spatial learning
2331:long-term memory
2307:Circadian rhythm
2138:oxidative stress
2100:prion pseudoknot
2075:181 and Asn197.
2053:Signal sequences
1825:
1824:
1796:
1789:
1772:
1756:
1755:
1747:
1695:
1694:
1691:RefSeq (protein)
1681:
1665:
1664:
1656:
1624:
1623:
1600:
1599:
1581:
1580:
1555:
1554:
1536:
1535:
1510:
1509:
1491:
1490:
1460:
1459:
1314:long-term memory
1188:nuclear membrane
1042:protease binding
970:
969:
956:
947:
940:
933:
932:
918:
858:
856:Top expressed in
851:
850:
820:endothelial cell
804:Brodmann area 23
796:
794:Top expressed in
789:
788:
768:
767:
751:
750:
741:
728:
717:
702:
695:
689:
678:
666:
650:
649:
640:
627:
616:
601:
594:
588:
577:
563:
547:
546:
541:
539:PRNP - orthologs
492:
485:
462:
73:
72:
67:
46:
45:
40:
28:
27:
8285:
8284:
8280:
8279:
8278:
8276:
8275:
8274:
8250:
8249:
8248:
8243:
8047:
7841:
7590:
7274:
6997:
6657:
6255:
6241:
6211:
6206:
6203:
6197:
6188:
6182:
6173:
6167:
6158:
6152:
6143:
6137:
6128:
6122:
6113:
6107:
6098:
6092:
6083:
6077:
6068:
6062:
6053:
6047:
6038:
6032:
6023:
6017:
6008:
6002:
5993:
5987:
5978:
5972:
5963:
5957:
5948:
5942:
5933:
5927:
5918:
5912:
5903:
5897:
5888:
5882:
5873:
5867:
5858:
5852:
5843:
5837:
5828:
5822:
5813:
5807:
5798:
5792:
5783:
5777:
5768:
5762:
5753:
5747:
5733:
5730:
5677:
5672:
5627:
5623:
5592:
5588:
5563:10.1038/nbt1271
5543:
5539:
5529:
5527:
5517:
5513:
5473:
5466:
5426:
5419:
5366:
5357:
5312:
5299:
5268:
5247:
5202:
5198:
5183:
5147:
5143:
5104:
5100:
5060:
5056:
5017:
5013:
4982:
4978:
4933:
4929:
4876:
4872:
4827:
4823:
4778:
4774:
4735:
4731:
4684:
4680:
4641:
4637:
4598:
4594:
4555:
4551:
4511:
4507:
4470:
4466:
4443:10.1038/nrg1616
4427:
4423:
4384:
4380:
4325:
4321:
4281:
4277:
4238:
4234:
4189:
4185:
4154:
4150:
4111:
4107:
4068:
4064:
4027:
4023:
4000:
3996:
3965:
3958:
3921:
3917:
3870:
3866:
3813:
3809:
3756:
3752:
3721:
3717:
3669:
3663:
3659:
3624:Nature Medicine
3620:
3616:
3571:
3567:
3522:
3518:
3489:Acta Virologica
3481:
3474:
3443:
3428:
3383:
3379:
3322:
3318:
3287:
3283:
3228:
3224:
3187:
3180:
3151:(11): 861–871.
3141:
3137:
3100:
3096:
3064:
3060:
3021:
3017:
2962:
2958:
2927:
2923:
2910:
2909:
2905:
2892:
2891:
2887:
2875:
2866:
2854:
2845:
2841:
2814:
2805:
2728:In humans, the
2614:
2493:
2487:
2454:
2441:
2408:
2376:
2323:
2281:
2276:
2226:
2150:
2112:
2025:
2002:
1972:
1860:also known as
1834:View/Edit Mouse
1829:View/Edit Human
1792:
1785:
1782:Location (UCSC)
1768:
1764:
1743:
1739:
1735:
1731:
1727:
1723:
1717:
1713:
1709:
1705:
1701:
1677:
1673:
1652:
1646:
1642:
1638:
1634:
1630:
1545:ENSG00000171867
1438:
1202:
1123:plasma membrane
1118:Golgi apparatus
1081:
1017:protein binding
1012:tubulin binding
952:
942:
941:
914:
905:
900:
896:
894:cingulate gyrus
892:
888:
884:
880:
876:
872:
868:
854:
843:
838:
834:
830:
826:
822:
818:
814:
810:
806:
792:
736:
723:
715:
705:
704:
703:
696:
676:
653:Gene location (
635:
622:
614:
604:
603:
602:
595:
573:
550:Gene location (
501:
488:
481:
82:
60:
24:
17:
12:
11:
5:
8283:
8273:
8272:
8267:
8262:
8245:
8244:
8242:
8241:
8236:
8231:
8226:
8221:
8216:
8211:
8206:
8201:
8196:
8191:
8186:
8181:
8176:
8171:
8166:
8161:
8156:
8151:
8146:
8141:
8136:
8131:
8126:
8121:
8116:
8111:
8106:
8101:
8096:
8091:
8086:
8081:
8076:
8071:
8066:
8061:
8055:
8053:
8049:
8048:
8046:
8045:
8040:
8035:
8030:
8025:
8020:
8015:
8010:
8005:
8000:
7995:
7990:
7985:
7980:
7975:
7970:
7965:
7960:
7955:
7950:
7945:
7940:
7935:
7930:
7925:
7920:
7915:
7910:
7905:
7900:
7895:
7890:
7885:
7880:
7875:
7870:
7865:
7860:
7855:
7849:
7847:
7843:
7842:
7840:
7839:
7834:
7825:
7820:
7815:
7810:
7805:
7800:
7795:
7790:
7785:
7780:
7779:
7778:
7773:
7763:
7758:
7753:
7748:
7743:
7738:
7733:
7728:
7723:
7718:
7713:
7708:
7703:
7698:
7692:
7683:
7678:
7677:
7676:
7671:
7661:
7656:
7655:
7654:
7649:
7639:
7634:
7629:
7624:
7619:
7614:
7609:
7604:
7598:
7596:
7592:
7591:
7589:
7588:
7583:
7578:
7573:
7568:
7563:
7558:
7553:
7548:
7543:
7538:
7533:
7528:
7523:
7518:
7513:
7508:
7503:
7502:
7501:
7496:
7486:
7481:
7476:
7471:
7470:
7469:
7464:
7459:
7449:
7444:
7439:
7434:
7429:
7428:
7427:
7422:
7412:
7407:
7402:
7397:
7392:
7387:
7382:
7381:
7380:
7375:
7365:
7359:
7354:
7349:
7344:
7335:
7330:
7329:
7328:
7323:
7318:
7308:
7303:
7298:
7293:
7288:
7282:
7280:
7276:
7275:
7273:
7272:
7267:
7262:
7257:
7252:
7247:
7242:
7237:
7232:
7227:
7222:
7217:
7212:
7207:
7202:
7197:
7192:
7187:
7182:
7177:
7172:
7167:
7162:
7157:
7152:
7147:
7146:
7145:
7140:
7130:
7129:
7128:
7123:
7113:
7108:
7103:
7098:
7093:
7088:
7083:
7078:
7073:
7068:
7063:
7058:
7053:
7052:
7051:
7046:
7036:
7031:
7026:
7021:
7016:
7011:
7005:
7003:
6999:
6998:
6996:
6995:
6990:
6985:
6980:
6975:
6970:
6965:
6960:
6955:
6946:
6941:
6936:
6931:
6926:
6921:
6920:
6919:
6914:
6909:
6904:
6899:
6894:
6884:
6879:
6874:
6869:
6864:
6859:
6858:
6857:
6852:
6842:
6837:
6832:
6827:
6822:
6817:
6812:
6807:
6802:
6801:
6800:
6795:
6790:
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6758:
6753:
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6711:
6706:
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6509:
6504:
6494:
6489:
6484:
6479:
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6464:
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6417:
6407:
6402:
6397:
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6390:
6385:
6380:
6375:
6365:
6360:
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6338:
6333:
6328:
6323:
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6311:
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6289:
6284:
6279:
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6225:
6217:
6208:
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6176:
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6168:
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6146:
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6138:
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6084:
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6026:
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6018:
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5988:
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5973:
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5714:
5706:
5700:
5699:
5694:
5684:
5676:
5675:External links
5673:
5671:
5670:
5621:
5602:(2): 620–625.
5586:
5557:(1): 132–138.
5537:
5511:
5484:(6): 405–410.
5464:
5437:(1–2): 89–95.
5417:
5355:
5297:
5278:(2): 227–244.
5245:
5196:
5194:
5193:
5141:
5114:(3): 167–176.
5098:
5071:(5): 387–397.
5054:
5011:
4992:(4): 397–403.
4976:
4927:
4870:
4821:
4772:
4745:(2): 139–144.
4729:
4678:
4651:(2): 116–120.
4635:
4608:(2): 275–276.
4592:
4565:(3): 734–737.
4549:
4522:(6): 688–692.
4505:
4464:
4437:(6): 435–450.
4421:
4378:
4319:
4275:
4232:
4203:(7): 444–449.
4183:
4164:(2): 349–353.
4148:
4121:(2): 173–181.
4105:
4078:(6): 731–742.
4062:
4021:
3994:
3956:
3915:
3864:
3807:
3750:
3725:Molecular Cell
3715:
3680:(2): 282–288.
3657:
3636:10.1038/nm1066
3614:
3565:
3516:
3495:(2): 179–184.
3472:
3453:(2): 673–728.
3426:
3397:(3): 753–758.
3377:
3347:10.1.1.401.781
3316:
3297:(4): 362–374.
3281:
3222:
3178:
3135:
3094:
3075:(2): 758–765.
3058:
3015:
2956:
2937:(4): 315–324.
2921:
2903:
2885:
2864:
2842:
2840:
2837:
2813:
2810:
2804:
2801:
2773:point mutation
2710:phenotypically
2682:excitotoxicity
2613:
2610:
2609:
2608:
2602:
2596:
2559:
2558:
2540:
2523:
2501:prion diseases
2489:Main article:
2486:
2483:
2453:
2450:
2440:
2437:
2407:
2404:
2381:synaptic cleft
2375:
2372:
2322:
2319:
2293:Purkinje cells
2280:
2279:Nervous system
2277:
2275:
2272:
2225:
2222:
2216:change at the
2214:conformational
2191:binding domain
2181:contains five
2168:anchor at its
2149:
2146:
2111:
2110:Ligand-binding
2108:
2065:golden hamster
2038:cell membranes
2023:
2001:
1998:
1971:
1968:
1887:form, and the
1874:nervous system
1841:
1840:
1837:
1836:
1831:
1821:
1820:
1814:
1813:
1810:
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1790:
1783:
1779:
1778:
1775:
1774:
1760:
1759:
1753:
1750:
1749:
1741:NP_001073592.1
1737:NP_001073591.1
1733:NP_001073590.1
1719:
1718:
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1195:
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1173:inclusion body
1170:
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1125:
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867:
863:
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859:
848:
845:
844:
842:
841:
837:
833:
829:
825:
824:spinal ganglia
821:
817:
813:
809:
805:
801:
798:
797:
785:
784:
776:
765:
759:
758:
755:RNA expression
747:
746:
743:
742:
734:
730:
729:
721:
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707:
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7127:
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7119:
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7109:
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5781:
5775:
5770:
5766:
5760:
5755:
5751:
5745:
5740:
5739:
5736:
5727:
5722:
5720:
5715:
5713:
5708:
5707:
5704:
5698:
5695:
5692:
5688:
5685:
5683:
5679:
5678:
5666:
5662:
5657:
5652:
5648:
5644:
5640:
5636:
5632:
5625:
5617:
5613:
5609:
5605:
5601:
5597:
5590:
5582:
5578:
5573:
5568:
5564:
5560:
5556:
5552:
5548:
5541:
5526:
5522:
5515:
5507:
5503:
5499:
5495:
5491:
5487:
5483:
5479:
5471:
5469:
5460:
5456:
5452:
5448:
5444:
5440:
5436:
5432:
5424:
5422:
5413:
5409:
5404:
5399:
5395:
5391:
5387:
5383:
5379:
5375:
5371:
5364:
5362:
5360:
5351:
5347:
5342:
5337:
5333:
5329:
5325:
5321:
5317:
5310:
5308:
5306:
5304:
5302:
5293:
5289:
5285:
5281:
5277:
5273:
5266:
5264:
5262:
5260:
5258:
5256:
5254:
5252:
5250:
5241:
5237:
5232:
5227:
5223:
5219:
5215:
5211:
5207:
5200:
5190:
5186:
5182:
5181:
5178:
5174:
5169:
5164:
5160:
5156:
5152:
5145:
5137:
5133:
5129:
5125:
5121:
5117:
5113:
5109:
5102:
5094:
5090:
5086:
5082:
5078:
5074:
5070:
5066:
5058:
5050:
5046:
5042:
5038:
5034:
5030:
5026:
5022:
5015:
5007:
5003:
4999:
4995:
4991:
4987:
4980:
4972:
4968:
4963:
4958:
4954:
4950:
4946:
4942:
4938:
4931:
4923:
4919:
4914:
4909:
4905:
4901:
4897:
4893:
4889:
4885:
4881:
4874:
4866:
4862:
4858:
4854:
4849:
4844:
4840:
4836:
4832:
4825:
4817:
4813:
4809:
4805:
4800:
4795:
4791:
4787:
4783:
4776:
4768:
4764:
4760:
4756:
4752:
4748:
4744:
4740:
4733:
4725:
4721:
4716:
4711:
4706:
4701:
4697:
4693:
4689:
4682:
4674:
4670:
4666:
4662:
4658:
4654:
4650:
4646:
4639:
4631:
4627:
4623:
4619:
4615:
4611:
4607:
4603:
4596:
4588:
4584:
4580:
4576:
4572:
4568:
4564:
4560:
4553:
4545:
4541:
4537:
4533:
4529:
4525:
4521:
4517:
4509:
4501:
4497:
4492:
4487:
4483:
4479:
4475:
4468:
4460:
4456:
4452:
4448:
4444:
4440:
4436:
4432:
4425:
4417:
4413:
4409:
4405:
4401:
4397:
4393:
4389:
4382:
4374:
4370:
4365:
4360:
4355:
4350:
4346:
4342:
4338:
4334:
4330:
4323:
4315:
4311:
4307:
4303:
4299:
4295:
4291:
4287:
4279:
4271:
4267:
4263:
4259:
4255:
4251:
4247:
4243:
4236:
4228:
4224:
4219:
4214:
4210:
4206:
4202:
4198:
4194:
4187:
4179:
4175:
4171:
4167:
4163:
4159:
4152:
4144:
4140:
4136:
4132:
4128:
4124:
4120:
4116:
4109:
4101:
4097:
4093:
4089:
4085:
4081:
4077:
4073:
4066:
4058:
4054:
4049:
4044:
4040:
4036:
4032:
4025:
4017:
4013:
4009:
4005:
3998:
3990:
3986:
3982:
3978:
3974:
3970:
3963:
3961:
3952:
3948:
3943:
3938:
3934:
3930:
3926:
3919:
3911:
3907:
3903:
3899:
3895:
3891:
3887:
3883:
3879:
3875:
3868:
3860:
3856:
3851:
3846:
3842:
3838:
3834:
3830:
3826:
3822:
3818:
3811:
3803:
3799:
3794:
3789:
3785:
3781:
3777:
3773:
3769:
3765:
3761:
3754:
3746:
3742:
3738:
3734:
3730:
3726:
3719:
3711:
3707:
3703:
3699:
3695:
3691:
3687:
3683:
3679:
3675:
3668:
3661:
3653:
3649:
3645:
3641:
3637:
3633:
3629:
3625:
3618:
3610:
3606:
3602:
3598:
3593:
3588:
3584:
3580:
3576:
3569:
3561:
3557:
3553:
3549:
3544:
3539:
3535:
3531:
3527:
3520:
3512:
3508:
3503:
3498:
3494:
3490:
3486:
3479:
3477:
3468:
3464:
3460:
3456:
3452:
3448:
3441:
3439:
3437:
3435:
3433:
3431:
3422:
3418:
3413:
3408:
3404:
3400:
3396:
3392:
3388:
3381:
3373:
3369:
3365:
3361:
3357:
3353:
3348:
3343:
3339:
3335:
3331:
3327:
3320:
3312:
3308:
3304:
3300:
3296:
3292:
3285:
3277:
3273:
3268:
3263:
3258:
3253:
3249:
3245:
3241:
3237:
3233:
3226:
3218:
3214:
3209:
3204:
3200:
3196:
3192:
3185:
3183:
3174:
3170:
3166:
3162:
3158:
3154:
3150:
3146:
3139:
3131:
3127:
3122:
3117:
3113:
3109:
3105:
3098:
3090:
3086:
3082:
3078:
3074:
3070:
3062:
3054:
3050:
3046:
3042:
3038:
3034:
3030:
3026:
3019:
3011:
3007:
3002:
2997:
2992:
2987:
2983:
2979:
2975:
2971:
2967:
2960:
2952:
2948:
2944:
2940:
2936:
2932:
2925:
2917:
2913:
2907:
2899:
2895:
2889:
2882:
2878:
2873:
2871:
2869:
2861:
2857:
2852:
2850:
2848:
2843:
2836:
2834:
2830:
2826:
2823:
2819:
2809:
2800:
2798:
2794:
2790:
2786:
2782:
2778:
2774:
2770:
2766:
2762:
2758:
2754:
2750:
2746:
2742:
2738:
2735:
2731:
2726:
2723:
2719:
2715:
2711:
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2679:
2675:
2674:NMDA receptor
2671:
2667:
2663:
2659:
2655:
2651:
2647:
2643:
2639:
2635:
2634:neurotoxicity
2631:
2627:
2623:
2619:
2606:
2603:
2600:
2597:
2594:
2591:
2590:
2589:
2586:
2584:
2580:
2576:
2571:
2569:
2565:
2556:
2552:
2548:
2547:aspartic acid
2544:
2541:
2539:
2535:
2531:
2527:
2524:
2521:
2517:
2513:
2512:glutamic acid
2509:
2506:
2505:
2504:
2502:
2498:
2492:
2482:
2480:
2476:
2475:lipid bilayer
2472:
2466:
2464:
2459:
2449:
2445:
2436:
2434:
2430:
2426:
2422:
2418:
2414:
2406:Immune system
2403:
2401:
2396:
2394:
2390:
2386:
2382:
2371:
2368:
2364:
2363:polymorphisms
2360:
2356:
2355:Down syndrome
2350:
2348:
2344:
2340:
2336:
2332:
2328:
2318:
2316:
2312:
2308:
2304:
2302:
2298:
2294:
2289:
2286:
2271:
2269:
2265:
2264:Polymorphisms
2261:
2259:
2255:
2251:
2246:
2244:
2239:
2235:
2231:
2221:
2219:
2215:
2211:
2207:
2203:
2199:
2196:
2192:
2188:
2184:
2180:
2179:Prion protein
2176:
2174:
2171:
2167:
2163:
2162:cell membrane
2159:
2155:
2145:
2143:
2140:arising from
2139:
2135:
2131:
2127:
2123:
2119:
2117:
2107:
2105:
2101:
2097:
2093:
2092:messenger RNA
2088:
2086:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2054:
2050:
2046:
2041:
2039:
2035:
2031:
2027:
2019:
2016:
2012:
2008:
1997:
1995:
1991:
1990:chromosome 20
1987:
1980:
1979:Chromosome 20
1976:
1967:
1965:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1925:
1921:
1918:
1914:
1910:
1906:
1902:
1898:
1894:
1890:
1886:
1883:: the normal
1882:
1877:
1875:
1871:
1867:
1863:
1859:
1856:
1852:
1848:
1835:
1830:
1826:
1822:
1819:
1815:
1808:
1806:
1803:
1799:
1795:
1791:
1788:
1784:
1780:
1773:
1771:
1767:
1761:
1757:
1754:
1748:
1746:
1742:
1738:
1734:
1730:
1726:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1693:
1689:
1682:
1680:
1676:
1670:
1666:
1663:
1657:
1655:
1649:
1645:
1641:
1637:
1633:
1629:
1625:
1622:
1620:RefSeq (mRNA)
1618:
1611:
1610:
1605:
1601:
1598:
1592:
1591:
1586:
1582:
1579:
1577:
1573:
1566:
1565:
1560:
1556:
1553:
1547:
1546:
1541:
1537:
1534:
1532:
1528:
1521:
1520:
1515:
1511:
1508:
1502:
1501:
1496:
1492:
1489:
1487:
1483:
1480:
1477:
1475:
1472:
1468:
1465:
1461:
1457:
1450:
1446:
1441:
1435:
1432:
1430:
1427:
1425:
1422:
1420:
1417:
1415:
1412:
1410:
1407:
1405:
1402:
1400:
1397:
1395:
1392:
1390:
1387:
1385:
1382:
1380:
1377:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1357:
1355:
1352:
1350:
1347:
1345:
1342:
1340:
1337:
1335:
1332:
1330:
1327:
1325:
1322:
1320:
1317:
1315:
1312:
1310:
1307:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1265:
1262:
1260:
1257:
1255:
1252:
1250:
1247:
1245:
1242:
1240:
1237:
1235:
1232:
1230:
1227:
1225:
1222:
1220:
1217:
1215:
1212:
1211:
1209:
1206:
1205:
1199:
1196:
1194:
1191:
1189:
1186:
1184:
1181:
1179:
1176:
1174:
1171:
1169:
1166:
1164:
1161:
1159:
1156:
1154:
1151:
1149:
1146:
1144:
1141:
1139:
1138:membrane raft
1136:
1134:
1131:
1129:
1126:
1124:
1121:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1103:mitochondrion
1101:
1099:
1096:
1094:
1091:
1090:
1088:
1085:
1084:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1032:lamin binding
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
984:
982:
979:
978:
975:
974:Gene ontology
971:
967:
955:
950:
946:
939:
934:
931:
929:
925:
917:
912:
901:
897:
893:
889:
885:
881:
877:
873:
869:
865:
864:
861:
857:
852:
849:
840:Pars compacta
839:
835:
831:
827:
823:
819:
815:
811:
807:
803:
802:
799:
795:
790:
787:
786:
783:
781:
777:
775:
774:
770:
769:
766:
764:
760:
756:
752:
748:
740:
735:
731:
727:
722:
712:
708:
701:
694:
688:
681:
673:
669:
665:
660:
656:
651:
647:
639:
634:
630:
626:
621:
611:
607:
600:
593:
587:
580:
576:
570:
566:
562:
557:
553:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
496:
491:
484:
479:
474:
463:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
79:
74:
71:
70:
66:
63:
56:
52:
47:
43:
39:
34:
29:
26:
22:
7765:
7685:
7663:
7641:
7488:
7451:
7414:
7367:
7337:
7310:
7132:
7038:
6886:
6615:
6367:
6199:
6184:
6169:
6154:
6139:
6124:
6109:
6094:
6079:
6064:
6049:
6034:
6019:
6004:
5989:
5974:
5959:
5944:
5929:
5914:
5899:
5884:
5869:
5854:
5839:
5824:
5809:
5794:
5779:
5764:
5749:
5638:
5634:
5624:
5599:
5595:
5589:
5554:
5550:
5540:
5528:. Retrieved
5524:
5514:
5481:
5477:
5434:
5430:
5377:
5373:
5326:(2): 35–44.
5323:
5319:
5275:
5271:
5213:
5209:
5199:
5189:ScienceDaily
5188:
5158:
5154:
5144:
5111:
5107:
5101:
5068:
5064:
5057:
5024:
5020:
5014:
4989:
4985:
4979:
4944:
4940:
4930:
4887:
4883:
4873:
4838:
4834:
4824:
4792:(1): 49–57.
4789:
4785:
4775:
4742:
4738:
4732:
4695:
4691:
4681:
4648:
4644:
4638:
4605:
4601:
4595:
4562:
4558:
4552:
4519:
4515:
4508:
4481:
4477:
4467:
4434:
4430:
4424:
4391:
4387:
4381:
4336:
4332:
4322:
4289:
4285:
4278:
4245:
4242:Neuroscience
4241:
4235:
4200:
4196:
4186:
4161:
4157:
4151:
4118:
4114:
4108:
4075:
4071:
4065:
4038:
4034:
4024:
4007:
4003:
3997:
3972:
3968:
3932:
3928:
3918:
3877:
3873:
3867:
3824:
3820:
3810:
3767:
3763:
3753:
3728:
3724:
3718:
3677:
3674:FEBS Letters
3673:
3660:
3627:
3623:
3617:
3582:
3578:
3568:
3536:(1): 69–76.
3533:
3529:
3519:
3492:
3488:
3450:
3446:
3394:
3390:
3380:
3329:
3325:
3319:
3294:
3290:
3284:
3239:
3235:
3225:
3198:
3194:
3148:
3144:
3138:
3111:
3107:
3097:
3072:
3068:
3061:
3028:
3024:
3018:
2973:
2969:
2959:
2934:
2930:
2924:
2915:
2906:
2897:
2888:
2815:
2812:Interactions
2806:
2788:
2776:
2744:
2737:polymorphism
2727:
2717:
2705:
2661:
2645:
2637:
2618:amyloid beta
2615:
2587:
2574:
2572:
2563:
2560:
2496:
2494:
2467:
2455:
2446:
2442:
2409:
2397:
2377:
2366:
2351:
2324:
2314:
2305:
2290:
2282:
2262:
2258:cytotoxicity
2253:
2247:
2227:
2208:-dependent.
2177:
2151:
2120:
2113:
2089:
2069:glycosylated
2047:long before
2042:
2015:antiparallel
2003:
1985:
1983:
1901:mitochondria
1896:
1892:
1884:
1878:
1861:
1854:
1850:
1846:
1844:
1766:NP_001265185
1763:
1722:
1715:NP_001258490
1711:NP_001073592
1707:NP_001073591
1703:NP_001073590
1675:NM_001278256
1672:
1654:NM_001271561
1651:
1644:NM_001080123
1640:NM_001080122
1636:NM_001080121
1607:
1588:
1562:
1543:
1517:
1498:
1478:
1473:
1128:cell surface
778:
771:
737:131,780,349
724:131,751,848
498:External IDs
81:
25:
8270:Amyloidosis
5732:PDB gallery
4010:(15): 462.
3975:: 439–477.
3827:(1): 4005.
3770:(1): 4004.
2822:cochaperone
2818:interaction
2700:events nor
2698:excitotoxic
2658:hippocampus
2568:amino acids
2413:lymphocytes
2393:hippocampus
2385:homeostasis
2243:proteolysis
2198:side-chains
2183:octapeptide
2098:structure (
2094:contains a
2045:amino acids
1745:NP_898902.1
1729:NP_000302.1
1198:postsynapse
476:Identifiers
8254:Categories
6250:(see also
5216:(1): 252.
4947:(1): 1–8.
2883:, May 2017
2862:, May 2017
2839:References
2757:Caucasians
2753:homozygote
2730:methionine
2722:transgenic
2555:methionine
2551:asparagine
2481:function.
2458:cell cycle
2297:cerebellum
2285:transgenic
2218:N-terminus
2170:C-terminal
2096:pseudoknot
1984:The human
1289:metabolism
1284:cell cycle
782:(ortholog)
636:4,701,590
623:4,686,350
519:HomoloGene
5530:1 January
4559:Neurology
4041:: 43–60.
3652:205383483
3342:CiteSeerX
2816:A strong
2714:epileptic
2626:oligomers
2532:102 from
2425:monocytes
2421:platelets
2234:secondary
2195:imidazole
2187:histidine
2130:manganese
2081:disulfide
2067:PrP, two
2026:-terminal
2011:α-helices
2000:Structure
1994:base pair
1905:misfolded
1770:NP_035300
1725:NP_898902
1699:NP_000302
1679:NM_011170
1632:NM_000311
1628:NM_183079
1464:Orthologs
1113:cytoplasm
898:subiculum
870:CA3 field
527:GeneCards
6244:Proteins
5682:GeneCard
5665:12093732
5616:17498662
5581:17195841
5506:20553167
5498:19030774
5459:31070331
5451:23399523
5412:19242475
5350:25343100
5292:23948943
5240:19308092
5177:19923577
5136:20822956
5128:12849238
5093:31976428
5085:11535002
5049:22688729
5041:12420099
5006:15354870
4971:16968391
4922:19242475
4865:26307975
4857:16805766
4808:15450159
4767:24917999
4724:10516306
4673:23642220
4665:16023289
4630:31538672
4622:12891686
4587:11352163
4544:21049364
4536:12796830
4500:15987701
4451:15931169
4416:17164351
4408:17156386
4373:20133875
4306:15837581
4270:42892475
4262:10391428
4178:10521590
4143:37511702
4135:15970215
4100:23409873
4057:14522848
4016:11688751
3989:18558863
3902:21350487
3859:35831291
3802:35831275
3745:34433091
3710:39791520
3644:15272267
3609:24329326
3601:16313516
3560:45647133
3552:11145979
3511:26104335
3467:18391177
3421:11160898
3372:10064966
3364:15933194
3276:21987789
3217:18073096
3201:(4): 9.
3173:20992257
3165:15494743
3130:11357156
2879:–
2858:–
2803:Research
2793:dementia
2676:via the
2624:. These
2471:GPI raft
2452:Cellular
2274:Function
2230:protease
2158:synapses
1889:protease
1881:isoforms
1818:Wikidata
1443:Sources:
1178:dendrite
1098:membrane
886:amygdala
8052:301–350
7846:251–300
7798:CD240CE
7595:201–250
7279:151–200
7002:101–150
5572:2813193
5403:2748841
5382:Bibcode
5341:4204584
5231:2671916
4962:1809729
4913:2748841
4892:Bibcode
4816:2637074
4759:2549468
4715:6782778
4579:9748018
4459:5575951
4364:2836680
4341:Bibcode
4314:2618712
4227:1346338
4218:6151859
4092:9876879
3951:8100741
3910:4399936
3882:Bibcode
3850:9279418
3829:Bibcode
3793:9279362
3772:Bibcode
3702:9280298
3682:Bibcode
3334:Bibcode
3326:Science
3311:7837269
3267:3198368
3244:Bibcode
3089:2877664
3053:3014653
3033:Bibcode
3025:Science
3010:3094007
2978:Bibcode
2951:3755672
2881:Ensembl
2860:Ensembl
2743:129 of
2593:Scrapie
2538:leucine
2534:proline
2473:in the
2400:neurite
2347:kinases
2343:laminin
2295:in the
2268:scrapie
2061:carboxy
2055:in the
2018:β-sheet
1958:(GSS),
1954:(FFI),
1950:(CJD),
1934:(TME),
1920:scrapie
1870:protein
1576:UniProt
1531:Ensembl
1470:Species
1449:QuickGO
1163:cytosol
1153:nucleus
890:decidua
757:pattern
483:Aliases
8059:CD300A
8018:CDw293
7803:CD240D
7664:CD213a
7642:CDw210
7607:CD202b
7581:CDw199
7576:CDw198
7230:CD140b
6662:51–100
5693:(MeSH)
5663:
5656:125391
5653:
5614:
5579:
5569:
5504:
5496:
5457:
5449:
5410:
5400:
5374:Nature
5348:
5338:
5290:
5238:
5228:
5175:
5134:
5126:
5091:
5083:
5047:
5039:
5004:
4969:
4959:
4920:
4910:
4884:Nature
4863:
4855:
4814:
4806:
4786:Neuron
4765:
4757:
4722:
4712:
4671:
4663:
4628:
4620:
4585:
4577:
4542:
4534:
4498:
4457:
4449:
4414:
4406:
4371:
4361:
4312:
4304:
4268:
4260:
4225:
4215:
4176:
4141:
4133:
4098:
4090:
4055:
4014:
3987:
3949:
3908:
3900:
3874:Nature
3857:
3847:
3800:
3790:
3743:
3708:
3700:
3650:
3642:
3607:
3599:
3558:
3550:
3509:
3465:
3419:
3409:
3370:
3362:
3344:
3309:
3274:
3264:
3215:
3171:
3163:
3128:
3087:
3051:
3008:
3001:386716
2998:
2949:
2749:allele
2734:valine
2630:neuron
2579:allele
2553:while
2520:valine
2518:while
2516:lysine
2429:T cell
2423:, and
2359:valine
2335:ataxia
2321:Memory
2301:Doppel
2134:nickel
2132:, and
2122:Copper
2116:ligand
2077:Murine
2059:- and
1962:, and
1903:. The
1804:search
1802:PubMed
1609:P04925
1590:P04156
1486:Entrez
928:BioGPS
507:176640
21:prions
8239:CD350
8234:CD349
8229:CD344
8224:CD340
8219:CD339
8214:CD338
8209:CD337
8204:CD336
8199:CD335
8194:CD334
8189:CD333
8184:CD332
8179:CD331
8174:CD329
8169:CD328
8164:CD327
8159:CD326
8154:CD325
8149:CD324
8144:CD322
8139:CD321
8134:CD320
8129:CD318
8124:CD317
8119:CD316
8114:CD315
8109:CD314
8104:CD312
8099:CD309
8094:CD307
8089:CD306
8084:CD305
8079:CD304
8074:CD303
8069:CD302
8064:CD301
8043:CD299
8038:CD298
8033:CD297
8028:CD295
8023:CD294
8013:CD292
8008:CD290
8003:CD289
7998:CD288
7993:CD286
7988:CD284
7983:CD283
7978:CD282
7973:CD281
7968:CD280
7963:CD279
7958:CD278
7953:CD276
7948:CD275
7943:CD274
7938:CD273
7933:CD272
7928:CD271
7923:CD269
7918:CD268
7913:CD267
7908:CD266
7903:CD265
7898:CD264
7893:CD263
7888:CD262
7883:CD261
7878:CD258
7873:CD257
7868:CD256
7863:CD254
7858:CD253
7853:CD252
7837:CD249
7832:CD248
7828:CD247
7823:CD246
7818:CD244
7813:CD243
7808:CD241
7793:CD239
7788:CD238
7783:CD236
7766:CD235
7761:CD234
7756:CD233
7751:CD230
7746:CD229
7741:CD228
7736:CD227
7731:CD226
7726:CD225
7721:CD224
7716:CD223
7711:CD222
7706:CD221
7701:CD220
7686:CD218
7681:CD217
7659:CD212
7637:CD209
7632:CD208
7627:CD207
7622:CD206
7617:CD205
7612:CD204
7602:CD201
7586:CD200
7571:CD197
7566:CD196
7561:CD195
7556:CD194
7551:CD193
7546:CD192
7541:CD191
7536:CD186
7531:CD185
7526:CD184
7521:CD183
7516:CD182
7511:CD181
7506:CD180
7489:CD179
7484:CD178
7479:CD177
7474:CD174
7452:CD172
7447:CD171
7442:CD170
7437:CD169
7432:CD168
7415:CD167
7410:CD166
7405:CD164
7400:CD163
7395:CD162
7390:CD161
7385:CD160
7368:CD159
7338:CD158
7333:CD157
7311:CD156
7306:CD155
7301:CD154
7296:CD153
7291:CD152
7286:CD151
7270:CD150
7265:CD148
7260:CD147
7255:CD146
7250:CD144
7245:CD143
7240:CD142
7235:CD141
7225:CD138
7220:CD137
7215:CD136
7210:CD135
7205:CD134
7200:CD133
7195:CD132
7190:CD131
7185:CD130
7180:CD129
7175:CD127
7170:CD126
7165:CD125
7160:CD124
7155:CD123
7150:CD122
7133:CD121
7116:CD120
7111:CD119
7106:CD118
7101:CD117
7096:CD116
7091:CD115
7086:CD114
7081:CD113
7076:CD112
7071:CD111
7066:CD110
7061:CD109
7056:CD108
7039:CD107
7034:CD106
7029:CD105
7024:CD104
7019:CD103
7014:CD102
7009:CD101
6993:CD100
5502:S2CID
5455:S2CID
5132:S2CID
5089:S2CID
5045:S2CID
4861:S2CID
4812:S2CID
4763:S2CID
4669:S2CID
4626:S2CID
4583:S2CID
4540:S2CID
4455:S2CID
4412:S2CID
4310:S2CID
4266:S2CID
4139:S2CID
4096:S2CID
3906:S2CID
3706:S2CID
3670:(PDF)
3648:S2CID
3605:S2CID
3556:S2CID
3412:30388
3368:S2CID
3169:S2CID
2833:Hsp90
2829:Hsp70
2761:PSEN1
2741:codon
2530:codon
2202:amide
2175:231.
2164:by a
2154:ionic
2057:amino
2020:, an
1917:ovine
1862:CD230
1519:19122
1479:Mouse
1474:Human
1445:Amigo
780:Mouse
773:Human
720:Start
655:Mouse
619:Start
615:20p13
552:Human
515:97769
6988:CD99
6983:CD98
6978:CD97
6973:CD96
6968:CD95
6963:CD94
6958:CD93
6953:CD92
6949:CD91
6944:CD90
6939:CD89
6934:CD88
6929:CD87
6924:CD86
6887:CD85
6882:CD84
6877:CD83
6872:CD82
6867:CD81
6862:CD80
6845:CD79
6840:CD78
6835:CD74
6830:CD73
6825:CD72
6820:CD71
6815:CD70
6810:CD69
6805:CD68
6768:CD66
6746:CD64
6741:CD63
6719:CD62
6714:CD61
6709:CD59
6704:CD58
6699:CD57
6694:CD56
6689:CD55
6684:CD54
6679:CD53
6674:CD52
6669:CD51
6653:CD50
6616:CD49
6611:CD48
6606:CD47
6601:CD46
6596:CD45
6591:CD44
6586:CD43
6559:CD42
6554:CD41
6549:CD40
6544:CD39
6539:CD38
6534:CD37
6529:CD36
6524:CD35
6519:CD34
6514:CD33
6497:CD32
6492:CD31
6487:CD30
6482:CD29
6477:CD28
6472:CD27
6467:CD26
6462:CD25
6457:CD24
6452:CD23
6447:CD22
6442:CD21
6437:CD20
6432:CD19
6427:CD18
6410:CD16
6405:CD15
6400:CD14
6395:CD13
6368:CD11
6363:CD10
6260:1–50
6200:1y2s
6185:1y15
6170:1xyx
6155:1xyu
6140:1uw3
6125:1tqc
6110:1tqb
6095:1tpx
6080:1qm3
6065:1qm1
6050:1qm0
6035:1qlz
6020:1qlx
6005:1oei
5990:1i4m
5975:1hjn
5960:1hjm
5945:1h0l
5930:1fo7
5915:1fkc
5900:1e1w
5885:1e1u
5870:1e1s
5855:1e1p
5840:1e1j
5825:1e1g
5810:1dx1
5795:1dx0
5780:1dwz
5765:1dwy
5750:1ag2
5661:PMID
5612:PMID
5577:PMID
5532:2007
5494:PMID
5447:PMID
5408:PMID
5346:PMID
5288:PMID
5236:PMID
5173:PMID
5124:PMID
5081:PMID
5037:PMID
5002:PMID
4967:PMID
4918:PMID
4853:PMID
4804:PMID
4755:PMID
4720:PMID
4661:PMID
4618:PMID
4575:PMID
4532:PMID
4496:PMID
4447:PMID
4404:PMID
4369:PMID
4302:PMID
4258:PMID
4223:PMID
4174:PMID
4131:PMID
4088:PMID
4053:PMID
4012:PMID
3985:PMID
3947:PMID
3929:Cell
3898:PMID
3855:PMID
3798:PMID
3741:PMID
3698:PMID
3640:PMID
3597:PMID
3548:PMID
3507:PMID
3463:PMID
3417:PMID
3360:PMID
3307:PMID
3272:PMID
3213:PMID
3161:PMID
3126:PMID
3085:PMID
3049:PMID
3006:PMID
2947:PMID
2789:PRNP
2777:PRNP
2771:. A
2765:APOE
2763:and
2745:PRNP
2718:PRNP
2706:PRNP
2662:PRNP
2646:PRNP
2638:PRNP
2605:Kuru
2583:kuru
2575:PRNP
2564:PRNP
2497:PRNP
2367:PRNP
2315:PRNP
2254:PRNP
2236:and
2126:zinc
2090:PrP
2030:COOH
1986:PRNP
1970:Gene
1960:kuru
1944:deer
1911:and
1858:gene
1855:PRNP
1845:The
1500:5621
832:pons
763:Bgee
711:Band
672:Chr.
610:Band
569:Chr.
531:PRNP
523:7904
503:OMIM
490:PRNP
460:4N9O
456:4KML
452:4E1I
448:4E1H
444:4DGI
440:3NVF
436:3NHC
432:3MD5
428:3MD4
424:3HJX
420:3HJ5
416:3HES
412:3HER
408:3HEQ
404:3HAK
400:3HAF
396:2W9E
392:2M8T
388:2LV1
384:2LSB
380:2LFT
376:2LEJ
372:2LBG
368:2KUN
364:2K1D
360:2IV6
356:2IV5
352:2IV4
348:1QM3
344:1QM2
340:1QM1
336:1QM0
332:1QLZ
328:1QLX
324:1OEI
320:1OEH
316:1I4M
312:1HJN
308:1HJM
304:1H0L
300:1FO7
296:1FKC
292:1E1W
288:1E1U
284:1E1S
280:1E1P
276:1E1J
272:1E1G
270:,%%s
268:4E1I
264:4E1H
260:4DGI
256:3NVF
252:3NHD
248:3NHC
244:3MD5
240:3MD4
236:3HJX
232:3HJ5
228:3HES
224:3HER
220:3HEQ
216:3HAK
212:3HAF
208:2W9E
204:2OL9
200:2LV1
196:2LSB
192:2LFT
188:2LEJ
184:2LBG
180:2KUN
176:2K1D
172:2IV6
168:2IV5
164:2IV4
160:1QM3
156:1QM2
152:1QM1
148:1QM0
144:1QLZ
140:1QLX
136:1OEI
132:1OEH
128:1I4M
124:1HJN
120:1HJM
116:1H0L
112:1FO7
108:1FKC
104:1E1W
100:1E1U
96:1E1S
92:1E1P
88:1E1J
84:1E1G
65:RCSB
62:PDBe
31:PRNP
6358:CD9
6346:CD8
6341:CD7
6336:CD6
6331:CD5
6326:CD4
6304:CD3
6299:CD2
6272:a-c
6267:CD1
5651:PMC
5643:doi
5604:doi
5600:358
5567:PMC
5559:doi
5486:doi
5439:doi
5435:326
5398:PMC
5390:doi
5378:457
5336:PMC
5328:doi
5280:doi
5226:PMC
5218:doi
5163:doi
5159:361
5116:doi
5073:doi
5029:doi
5025:249
4994:doi
4957:PMC
4949:doi
4945:146
4908:PMC
4900:doi
4888:457
4843:doi
4794:doi
4747:doi
4743:103
4710:PMC
4700:doi
4653:doi
4649:386
4610:doi
4567:doi
4524:doi
4520:250
4486:doi
4439:doi
4396:doi
4359:PMC
4349:doi
4337:107
4294:doi
4250:doi
4213:PMC
4205:doi
4201:326
4166:doi
4123:doi
4119:162
4080:doi
4043:doi
4008:149
3977:doi
3937:doi
3890:doi
3878:470
3845:PMC
3837:doi
3788:PMC
3780:doi
3733:doi
3690:doi
3678:413
3632:doi
3587:doi
3538:doi
3497:doi
3455:doi
3407:PMC
3399:doi
3352:doi
3330:308
3299:doi
3295:245
3262:PMC
3252:doi
3240:108
3203:doi
3153:doi
3116:doi
3112:344
3077:doi
3073:140
3041:doi
3029:233
2996:PMC
2986:doi
2939:doi
2931:DNA
2825:Hop
2739:at
2694:FYN
2690:tau
2678:Fyn
2536:to
2365:in
2210:NMR
2173:Ser
2085:Cys
2073:Asn
1897:PrP
1893:PrP
1885:PrP
1851:PrP
733:End
632:End
535:OMA
511:MGI
55:PDB
8256::
7830:-
6951:-
6292:1E
6287:1D
6282:1B
6277:1A
6246::
5659:.
5649:.
5639:21
5637:.
5633:.
5610:.
5598:.
5575:.
5565:.
5555:25
5553:.
5549:.
5523:.
5500:.
5492:.
5482:29
5480:.
5467:^
5453:.
5445:.
5433:.
5420:^
5406:.
5396:.
5388:.
5376:.
5372:.
5358:^
5344:.
5334:.
5322:.
5318:.
5300:^
5286:.
5276:38
5274:.
5248:^
5234:.
5224:.
5212:.
5208:.
5187:.
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