306:
283:
205:
180:
564:
557:
312:
211:
4219:
4239:
1218:
DLK has several different interactions that contribute to mammalian nervous system development. For axon growth, DLK phosphorylates MAP2K4/7 which then phosphorylates JNK, activating it. In neuronal migration DLK phosphorylates MAP2K4/7 which phosphorylates JNK, and also interacts with JIP which then
1157:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization
2012:
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction
47:
1219:
interacts with MAP2K4/7 and JNK. There is a similar interaction for neuronal apoptosis, where DLK phosphorylates JIP3 and MAP2K7, which both phosphorylate JNK. It is evident then that DLK interactions are a versatile and critical part of neuronal development in mammals.
1194:
or JNK. Several experiments have implicated this interaction as having a role in the developing mammalian nervous system. For example, neuronal migration and axon growth are critical components of neuronal development. DLK null mice have defects in neuronal migration,
1158:
via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
319:
218:
1207:. In addition, inhibition of DLK or JNK delays radial migration and disrupts the formation of the neocortex in mice. Another important function of the developing mammalian nervous system is neuronal
1625:"Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin"
1569:"Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases"
2082:
2367:
2075:
1969:"The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation"
852:
2068:
1534:"Localization of the human zipper protein kinase gene (ZPK) to chromosome 12q13 by fluorescence in situ hybridization and somatic cell hybrid analysis"
833:
141:
2275:
1800:"MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase"
3620:
1296:
1278:
3662:
2823:
2126:
3771:
1602:
Hirai S, Izawa M, Osada S, Spyrou G, Ohno S (1996). "Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK".
2509:
2396:
1083:
1076:
2784:
3757:
3576:
3222:
2818:
2808:
2803:
2113:
2095:
4313:
3859:
3740:
1358:
4284:
3446:
2315:
1660:"Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain"
1211:. The absence of DLK also protects cultured mice sensory neurons from apoptosis that would normally be triggered by a lack of
4303:
3510:
2485:
1261:
3766:
1903:
Itoh A, Wang Z, Ito Y, Reddy UR, Itoh T (2004). "SP3 acts as a positive regulator on the core promoter of human ZPK gene".
44:
2300:
1240:
1798:
Fukuyama K, Yoshida M, Yamashita A, Deyama T, Baba M, Suzuki A, Mohri H, Ikezawa Z, Nakajima H, Hirai S, Ohno S (2000).
3498:
1730:"ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation"
1190:
MAP3K12, otherwise known as DLK, can initiate coordinated signalling cascades that culminate in the phosphorylation of
3823:
305:
3938:
2755:
2745:
2430:
2060:
3437:
282:
3706:
3378:
2740:
2731:
1265:
1244:
897:
4094:
3121:
2618:
2609:
2266:
2212:
204:
179:
1934:"Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation"
878:
2309:
121:
318:
217:
1167:
311:
210:
4277:
4209:
3333:
3151:
2647:
4195:
4182:
4169:
4156:
4143:
4130:
4117:
4079:
3323:
3318:
3313:
3303:
3298:
3293:
3283:
3078:
2853:
2449:
1199:
of several different axonal tracts and reduced axon number in various areas of the brain such as the
108:
4089:
4043:
3986:
3546:
3537:
3488:
2254:
2099:
1191:
1059:
1051:
1026:
1000:
992:
967:
129:
3991:
3846:
3269:
1055:
1030:
996:
971:
1215:. This, among other experiments, heavily implicates it as having a role in neuronal apoptosis.
1765:"Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells"
4270:
4012:
3931:
2545:
193:
149:
1316:"Cloning of a novel putative protein kinase having a leucine zipper domain from human brain"
4084:
3112:
2035:
1835:"The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis"
112:, DLK, MEKK12, MUK, ZPK, ZPKP1, mitogen-activated protein kinase kinase kinase 12, HP09298
8:
4048:
3221:
1212:
2112:
1480:"The DLK signalling pathway—a double-edged sword in neural development and regeneration"
4308:
3981:
3723:
3677:
2048:
1504:
1479:
153:
1585:
1568:
767:
762:
757:
752:
747:
742:
737:
732:
727:
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696:
691:
686:
681:
676:
660:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
2983:
2692:
2090:
2040:
2000:
1955:
1920:
1891:
1856:
1821:
1786:
1751:
1716:
1681:
1646:
1611:
1590:
1555:
1550:
1533:
1509:
1447:
1406:
1401:
1376:
1337:
101:
37:
133:
4027:
4022:
3996:
3924:
2721:
2712:
2642:
2633:
2579:
2570:
2227:
2052:
2030:
2022:
1990:
1980:
1945:
1912:
1881:
1846:
1811:
1776:
1741:
1706:
1671:
1636:
1580:
1545:
1499:
1491:
1437:
1396:
1388:
1327:
1204:
1200:
398:
329:
273:
228:
4258:
4074:
4058:
3971:
3402:
2473:
2468:
2463:
373:
157:
1301:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1283:
National Center for
Biotechnology Information, U.S. National Library of Medicine
563:
556:
4254:
4223:
4112:
4053:
2026:
1916:
1781:
1764:
474:
1995:
4297:
4250:
4017:
3976:
2458:
1711:
1694:
1676:
1659:
1641:
1624:
1442:
1425:
592:
2526:
655:
534:
412:
3966:
3397:
2222:
2044:
2004:
1985:
1968:
1959:
1950:
1933:
1924:
1895:
1886:
1869:
1860:
1851:
1834:
1825:
1816:
1799:
1790:
1755:
1746:
1729:
1720:
1513:
1451:
1410:
1392:
1332:
1315:
391:
170:
1870:"Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex"
1685:
1650:
1615:
1594:
1559:
1495:
1341:
1123:
1118:
4190:
4125:
3961:
3603:
3235:
3175:
3058:
2978:
2702:
942:
923:
1833:
HĂ©bert SS, Daviau A, Grondin G, Latreille M, Aubin RA, Blouin R (2000).
1359:"Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12"
3691:
2165:
1728:
Reddy UR, Basu A, Bannerman P, Ikegaki N, Reddy CD, Pleasure D (1999).
1196:
290:
187:
137:
1695:"The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate"
1658:
Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (1997).
1426:"The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate"
78:
74:
70:
66:
4164:
4138:
2652:
1377:"The JIP group of mitogen-activated protein kinase scaffold proteins"
1208:
797:
357:
344:
256:
243:
145:
1424:
Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB (Apr 1999).
4218:
3008:
2903:
2898:
2893:
1375:
Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (Oct 1999).
1179:
1171:
1107:
2368:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
1967:
Robitaille H, Proulx R, Robitaille K, Blouin R, Germain L (2005).
3667:
3645:
3640:
3630:
3427:
3422:
3417:
3412:
3407:
3392:
3387:
3038:
3003:
2242:
2237:
2232:
909:
864:
782:
778:
1966:
1693:
Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB (1999).
125:
4177:
3947:
3897:
3892:
3887:
3882:
3877:
3872:
3867:
3818:
3813:
3808:
3803:
3798:
3781:
3776:
3650:
3635:
3586:
3581:
3566:
3561:
3556:
3551:
3525:
3520:
3515:
3503:
3481:
3476:
3368:
3343:
3018:
2843:
2838:
2833:
2828:
2813:
2657:
2594:
2589:
2584:
2560:
2386:
2381:
2355:
2350:
2345:
2335:
2330:
2320:
2160:
2091:
1175:
1139:
1091:
819:
572:
1797:
4151:
3793:
3786:
3696:
3593:
3493:
3471:
3466:
3461:
3456:
3451:
3363:
3358:
3353:
3348:
3338:
3308:
3288:
3165:
3160:
3141:
3136:
3126:
3102:
3097:
3092:
3068:
3063:
3053:
3048:
3043:
3033:
3013:
2998:
2993:
2988:
2968:
2963:
2953:
2948:
2943:
2938:
2933:
2923:
2918:
2913:
2908:
2888:
2883:
2878:
2873:
2868:
2863:
2848:
2798:
2793:
2687:
2682:
2677:
2672:
2667:
2662:
2623:
2555:
2550:
2499:
2494:
2420:
2415:
2410:
2376:
2170:
2155:
2150:
2145:
2140:
2135:
1763:
Douziech M, Laberge G, Grondin G, Daigle N, Blouin R (1999).
1374:
1832:
1762:
4246:
4238:
3686:
3613:
3608:
3598:
3571:
3328:
3278:
3259:
3254:
3249:
3244:
3199:
3194:
3189:
3184:
3131:
3087:
3028:
3023:
2973:
2958:
2928:
2858:
2774:
2769:
2764:
2697:
2599:
2540:
2535:
2439:
2405:
2290:
2285:
2280:
2249:
2217:
2205:
2200:
2195:
2185:
2180:
1146:
3916:
1867:
3655:
2190:
2175:
1727:
3845:
2011:
381:
1931:
1657:
1692:
1423:
4207:
1623:
Mata M, Merritt SE, Fan G, Yu GG, Holzman LB (1996).
1601:
1531:
753:
negative regulation of motor neuron apoptotic process
546:
763:
positive regulation of transcription, DNA-templated
2013:network: a resource for annotating the proteome".
1868:Figueroa C, Tarras S, Taylor J, Vojtek AB (2004).
1257:
1255:
1253:
1236:
1234:
1232:
1566:
328:
227:
4295:
1902:
1622:
1250:
1229:
1532:Reddy UR, Nycum L, Slavc I, Biegel JA (1995).
1477:
1370:
1368:
1262:GRCm38: Ensembl release 89: ENSMUSG00000023050
4278:
3932:
2127:Non-specific serine/threonine protein kinases
2076:
1932:Graves PR, Winkfield KM, Haystead TA (2005).
1313:
768:positive regulation of ERK1 and ERK2 cascade
1417:
1365:
1241:GRCh38: Ensembl release 89: ENSG00000139625
4285:
4271:
3939:
3925:
2510:Goodpasture-antigen-binding protein kinase
2083:
2069:
1473:
1471:
1469:
1467:
1465:
1463:
1461:
1307:
3223:Serine/threonine-specific protein kinases
2397:(isocitrate dehydrogenase (NADP+)) kinase
2114:Serine/threonine-specific protein kinases
2096:Serine/threonine-specific protein kinases
2034:
1994:
1984:
1949:
1885:
1850:
1815:
1780:
1745:
1710:
1675:
1640:
1584:
1549:
1503:
1441:
1400:
1331:
3758:Receptor protein serine/threonine kinase
1353:
1351:
651:protein serine/threonine kinase activity
3741:Low-density-lipoprotein receptor kinase
1458:
4296:
1567:Holzman LB, Merritt SE, Fan G (1995).
1185:
3920:
3844:
3220:
2486:Fas-activated serine/threonine kinase
2111:
2064:
1348:
333:
294:
289:
232:
191:
186:
4233:
3858:
3767:Bone morphogenetic protein receptors
2301:Dephospho-(reductase kinase) kinase
1136:Mitogen-activated protein kinase 12
13:
2756:G-protein coupled receptor kinases
1524:
748:peptidyl-threonine phosphorylation
14:
4325:
2746:Beta adrenergic receptor kinase-2
2431:(tyrosine 3-monooxygenase) kinase
1478:Tedeschi A, Bradke F (May 2013).
1314:Reddy UR, Pleasure D (Aug 1994).
1142:that in humans is encoded by the
718:intracellular signal transduction
661:JUN kinase kinase kinase activity
636:MAP kinase kinase kinase activity
621:protein homodimerization activity
4237:
4217:
3438:Mitogen-activated protein kinase
562:
555:
317:
310:
304:
281:
216:
209:
203:
178:
3824:Anti-MĂĽllerian hormone receptor
3707:(acetyl-CoA carboxylase) kinase
3379:(RNA-polymerase)-subunit kinase
2741:Beta adrenergic receptor kinase
2732:Beta adrenergic receptor kinase
1161:
738:peptidyl-serine phosphorylation
4314:Human chromosome 12 gene stubs
3447:Extracellular signal-regulated
2036:11858/00-001M-0000-0010-8592-0
1289:
1271:
573:More reference expression data
535:More reference expression data
423:right hemisphere of cerebellum
1:
3511:P38 mitogen-activated protein
2610:cGMP-dependent protein kinase
2571:cAMP-dependent protein kinase
2267:Pyruvate dehydrogenase kinase
2213:Ataxia telangiectasia mutated
1905:Biochem. Biophys. Res. Commun
1586:10.1016/S0021-9258(18)47353-X
1222:
513:tunica media of zone of aorta
302:
201:
4304:Genes on human chromosome 12
4257:. You can help Knowledge by
2310:AMP-activated protein kinase
1551:10.1016/0888-7543(95)80069-X
7:
3946:
3225:(EC 2.7.11.21-EC 2.7.11.30)
1152:
743:protein autophosphorylation
10:
4330:
4232:
3152:Elongation factor 2 kinase
2116:(EC 2.7.11.1-EC 2.7.11.20)
2027:10.1016/j.cell.2005.08.029
1917:10.1016/j.bbrc.2003.11.152
1782:10.1177/002215549904701008
1320:Biochem Biophys Res Commun
1166:MAP3K12 has been shown to
1084:Chr 15: 102.41 – 102.43 Mb
656:signal transducer activity
4103:
4095:Michaelis–Menten kinetics
4067:
4036:
4005:
3954:
3854:
3840:
3756:
3739:
3722:
3705:
3676:
3547:MAP kinase kinase kinases
3536:
3436:
3377:
3268:
3234:
3230:
3216:
3174:
3150:
3111:
3079:Myosin light-chain kinase
3077:
2785:Ca2+/calmodulin-dependent
2783:
2754:
2730:
2711:
2632:
2608:
2569:
2525:
2508:
2484:
2450:Myosin-heavy-chain kinase
2448:
2429:
2395:
2366:
2299:
2265:
2125:
2121:
2107:
1297:"Mouse PubMed Reference:"
1279:"Human PubMed Reference:"
1122:
1117:
1113:
1106:
1090:
1071:
1048:
1044:
1023:
1019:
1012:
989:
985:
964:
960:
953:
940:
936:
921:
917:
908:
895:
891:
876:
872:
863:
850:
846:
831:
827:
818:
803:
796:
792:
776:
591:
587:
570:
554:
545:
532:
481:
472:
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
63:
58:
41:
36:
31:
27:
23:
18:
3987:Diffusion-limited enzyme
3847:Dual-specificity kinases
1712:10.1074/jbc.274.15.10195
1677:10.1074/jbc.272.45.28622
1642:10.1074/jbc.271.28.16888
1443:10.1074/jbc.274.15.10195
1192:C-Jun N-terminal kinases
3270:Cyclin-dependent kinase
1077:Chr 12: 53.48 – 53.5 Mb
728:protein phosphorylation
611:protein kinase activity
517:external carotid artery
505:internal carotid artery
1986:10.1074/jbc.M411619200
1951:10.1074/jbc.M412538200
1887:10.1074/jbc.M307357200
1852:10.1074/jbc.M006528200
1817:10.1074/jbc.M001488200
1769:J. Histochem. Cytochem
1747:10.1038/sj.onc.1202813
1393:10.1128/mcb.19.10.7245
1333:10.1006/bbrc.1994.1972
646:protein kinase binding
4080:Eadie–Hofstee diagram
4013:Allosteric regulation
1496:10.1038/embor.2013.64
296:Chromosome 15 (mouse)
194:Chromosome 12 (human)
4090:Lineweaver–Burk plot
3113:Phosphorylase kinase
606:transferase activity
59:List of PDB id codes
32:Available structures
1186:Role in development
501:submandibular gland
447:canal of the cervix
158:MAP3K12 - orthologs
4245:This article on a
4049:Enzyme superfamily
3982:Enzyme promiscuity
3724:Tropomyosin kinase
3678:Tau-protein kinase
1996:20.500.11794/16685
898:ENSMUSG00000023050
711:Biological process
670:Cellular component
616:nucleotide binding
599:Molecular function
521:intercostal muscle
509:lobe of cerebellum
493:supraoptic nucleus
443:anterior pituitary
439:right frontal lobe
431:right uterine tube
4266:
4265:
4205:
4204:
3914:
3913:
3910:
3909:
3906:
3905:
3836:
3835:
3832:
3831:
3212:
3211:
3208:
3207:
2693:Protein kinase N1
2648:Protein kinase Cζ
1705:(15): 10195–202.
1436:(15): 10195–202.
1133:
1132:
1129:
1128:
1102:
1101:
1067:
1066:
1038:
1037:
1008:
1007:
979:
978:
949:
948:
930:
929:
904:
903:
885:
884:
859:
858:
840:
839:
788:
787:
583:
582:
579:
578:
541:
540:
528:
527:
466:
465:
451:cerebellar vermis
364:
363:
263:
262:
90:
89:
86:
85:
42:Ortholog search:
4321:
4287:
4280:
4273:
4241:
4234:
4222:
4221:
4213:
4085:Hanes–Woolf plot
4028:Enzyme activator
4023:Enzyme inhibitor
3997:Enzyme catalysis
3941:
3934:
3927:
3918:
3917:
3856:
3855:
3842:
3841:
3489:C-Jun N-terminal
3232:
3231:
3218:
3217:
2722:Rhodopsin kinase
2713:Rhodopsin kinase
2643:Protein kinase C
2634:Protein kinase C
2619:Protein kinase G
2580:Protein kinase A
2191:Protein kinase B
2123:
2122:
2109:
2108:
2085:
2078:
2071:
2062:
2061:
2056:
2038:
2008:
1998:
1988:
1979:(13): 12732–41.
1963:
1953:
1928:
1899:
1889:
1864:
1854:
1845:(42): 32482–90.
1829:
1819:
1810:(28): 21247–54.
1794:
1784:
1759:
1749:
1724:
1714:
1689:
1679:
1654:
1644:
1635:(28): 16888–96.
1619:
1598:
1588:
1579:(49): 30808–17.
1563:
1553:
1518:
1517:
1507:
1475:
1456:
1455:
1445:
1421:
1415:
1414:
1404:
1372:
1363:
1362:
1355:
1346:
1345:
1335:
1311:
1305:
1304:
1293:
1287:
1286:
1275:
1269:
1259:
1248:
1238:
1205:internal capsule
1115:
1114:
1086:
1079:
1062:
1042:
1041:
1033:
1017:
1016:
1013:RefSeq (protein)
1003:
983:
982:
974:
958:
957:
934:
933:
915:
914:
889:
888:
870:
869:
844:
843:
825:
824:
794:
793:
589:
588:
575:
566:
559:
552:
551:
537:
477:
475:Top expressed in
470:
469:
415:
413:Top expressed in
408:
407:
387:
386:
370:
369:
360:
347:
336:
321:
314:
308:
297:
285:
269:
268:
259:
246:
235:
220:
213:
207:
196:
182:
166:
165:
160:
111:
104:
81:
56:
55:
50:
29:
28:
16:
15:
4329:
4328:
4324:
4323:
4322:
4320:
4319:
4318:
4294:
4293:
4292:
4291:
4230:
4228:
4216:
4208:
4206:
4201:
4113:Oxidoreductases
4099:
4075:Enzyme kinetics
4063:
4059:List of enzymes
4032:
4001:
3972:Catalytic triad
3950:
3945:
3915:
3902:
3850:
3828:
3752:
3735:
3718:
3701:
3672:
3532:
3432:
3403:P70-S6 Kinase 1
3373:
3264:
3226:
3204:
3170:
3146:
3107:
3073:
2779:
2750:
2726:
2707:
2628:
2604:
2565:
2521:
2504:
2480:
2474:Aurora C kinase
2469:Aurora B kinase
2464:Aurora A kinase
2444:
2425:
2391:
2362:
2295:
2261:
2117:
2103:
2089:
2059:
1944:(10): 9363–74.
1880:(48): 47922–7.
1775:(10): 1287–96.
1740:(31): 4474–84.
1670:(45): 28622–9.
1527:
1525:Further reading
1522:
1521:
1476:
1459:
1422:
1418:
1387:(10): 7245–54.
1381:Mol. Cell. Biol
1373:
1366:
1357:
1356:
1349:
1312:
1308:
1295:
1294:
1290:
1277:
1276:
1272:
1260:
1251:
1239:
1230:
1225:
1188:
1164:
1155:
1124:View/Edit Mouse
1119:View/Edit Human
1082:
1075:
1072:Location (UCSC)
1058:
1054:
1050:
1029:
1025:
999:
995:
991:
970:
966:
879:ENSG00000139625
772:
723:phosphorylation
706:
697:plasma membrane
665:
631:protein binding
626:kinase activity
571:
561:
560:
533:
524:
519:
515:
511:
507:
503:
499:
495:
491:
487:
485:ascending aorta
473:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
355:
342:
334:
324:
323:
322:
315:
295:
272:Gene location (
254:
241:
233:
223:
222:
221:
214:
192:
169:Gene location (
120:
107:
100:
65:
43:
12:
11:
5:
4327:
4317:
4316:
4311:
4306:
4290:
4289:
4282:
4275:
4267:
4264:
4263:
4242:
4227:
4226:
4203:
4202:
4200:
4199:
4186:
4173:
4160:
4147:
4134:
4121:
4107:
4105:
4101:
4100:
4098:
4097:
4092:
4087:
4082:
4077:
4071:
4069:
4065:
4064:
4062:
4061:
4056:
4051:
4046:
4040:
4038:
4037:Classification
4034:
4033:
4031:
4030:
4025:
4020:
4015:
4009:
4007:
4003:
4002:
4000:
3999:
3994:
3989:
3984:
3979:
3974:
3969:
3964:
3958:
3956:
3952:
3951:
3944:
3943:
3936:
3929:
3921:
3912:
3911:
3908:
3907:
3904:
3903:
3901:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3864:
3862:
3852:
3851:
3838:
3837:
3834:
3833:
3830:
3829:
3827:
3826:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3790:
3789:
3784:
3779:
3774:
3763:
3761:
3760:(EC 2.7.11.30)
3754:
3753:
3751:
3750:
3746:
3744:
3743:(EC 2.7.11.29)
3737:
3736:
3734:
3733:
3729:
3727:
3726:(EC 2.7.11.28)
3720:
3719:
3717:
3716:
3712:
3710:
3709:(EC 2.7.11.27)
3703:
3702:
3700:
3699:
3694:
3689:
3683:
3681:
3680:(EC 2.7.11.26)
3674:
3673:
3671:
3670:
3665:
3660:
3659:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3618:
3617:
3616:
3611:
3606:
3601:
3591:
3590:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3543:
3541:
3540:(EC 2.7.11.25)
3534:
3533:
3531:
3530:
3529:
3528:
3523:
3518:
3508:
3507:
3506:
3501:
3496:
3486:
3485:
3484:
3479:
3474:
3469:
3464:
3459:
3454:
3443:
3441:
3440:(EC 2.7.11.24)
3434:
3433:
3431:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3384:
3382:
3381:(EC 2.7.11.23)
3375:
3374:
3372:
3371:
3366:
3361:
3356:
3351:
3346:
3341:
3336:
3331:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3275:
3273:
3272:(EC 2.7.11.22)
3266:
3265:
3263:
3262:
3257:
3252:
3247:
3241:
3239:
3238:(EC 2.7.11.21)
3228:
3227:
3214:
3213:
3210:
3209:
3206:
3205:
3203:
3202:
3197:
3192:
3187:
3181:
3179:
3178:(EC 2.7.11.21)
3172:
3171:
3169:
3168:
3163:
3157:
3155:
3154:(EC 2.7.11.20)
3148:
3147:
3145:
3144:
3139:
3134:
3129:
3124:
3118:
3116:
3115:(EC 2.7.11.19)
3109:
3108:
3106:
3105:
3100:
3095:
3090:
3084:
3082:
3081:(EC 2.7.11.18)
3075:
3074:
3072:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2806:
2801:
2796:
2790:
2788:
2787:(EC 2.7.11.17)
2781:
2780:
2778:
2777:
2772:
2767:
2761:
2759:
2758:(EC 2.7.11.16)
2752:
2751:
2749:
2748:
2743:
2737:
2735:
2734:(EC 2.7.11.15)
2728:
2727:
2725:
2724:
2718:
2716:
2715:(EC 2.7.11.14)
2709:
2708:
2706:
2705:
2700:
2695:
2690:
2685:
2680:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2639:
2637:
2636:(EC 2.7.11.13)
2630:
2629:
2627:
2626:
2621:
2615:
2613:
2612:(EC 2.7.11.12)
2606:
2605:
2603:
2602:
2597:
2592:
2587:
2582:
2576:
2574:
2573:(EC 2.7.11.11)
2567:
2566:
2564:
2563:
2558:
2553:
2548:
2543:
2538:
2532:
2530:
2529:(EC 2.7.11.10)
2523:
2522:
2520:
2519:
2515:
2513:
2506:
2505:
2503:
2502:
2497:
2491:
2489:
2482:
2481:
2479:
2478:
2477:
2476:
2471:
2466:
2455:
2453:
2446:
2445:
2443:
2442:
2436:
2434:
2427:
2426:
2424:
2423:
2418:
2413:
2408:
2402:
2400:
2393:
2392:
2390:
2389:
2384:
2379:
2373:
2371:
2364:
2363:
2361:
2360:
2359:
2358:
2353:
2348:
2340:
2339:
2338:
2333:
2325:
2324:
2323:
2318:
2306:
2304:
2297:
2296:
2294:
2293:
2288:
2283:
2278:
2272:
2270:
2263:
2262:
2260:
2259:
2258:
2257:
2247:
2246:
2245:
2240:
2235:
2230:
2220:
2215:
2210:
2209:
2208:
2203:
2198:
2188:
2183:
2178:
2173:
2168:
2163:
2158:
2153:
2148:
2143:
2138:
2132:
2130:
2119:
2118:
2105:
2104:
2088:
2087:
2080:
2073:
2065:
2058:
2057:
2009:
1964:
1929:
1900:
1865:
1830:
1795:
1760:
1725:
1690:
1655:
1620:
1599:
1564:
1528:
1526:
1523:
1520:
1519:
1490:(7): 605–614.
1457:
1416:
1364:
1347:
1306:
1288:
1270:
1249:
1227:
1226:
1224:
1221:
1187:
1184:
1163:
1160:
1154:
1151:
1131:
1130:
1127:
1126:
1121:
1111:
1110:
1104:
1103:
1100:
1099:
1097:
1095:
1088:
1087:
1080:
1073:
1069:
1068:
1065:
1064:
1046:
1045:
1039:
1036:
1035:
1021:
1020:
1014:
1010:
1009:
1006:
1005:
987:
986:
980:
977:
976:
962:
961:
955:
951:
950:
947:
946:
938:
937:
931:
928:
927:
919:
918:
912:
906:
905:
902:
901:
893:
892:
886:
883:
882:
874:
873:
867:
861:
860:
857:
856:
848:
847:
841:
838:
837:
829:
828:
822:
816:
815:
810:
805:
801:
800:
790:
789:
786:
785:
774:
773:
771:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
684:
679:
673:
671:
667:
666:
664:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
602:
600:
596:
595:
585:
584:
581:
580:
577:
576:
568:
567:
549:
543:
542:
539:
538:
530:
529:
526:
525:
523:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
479:
478:
467:
464:
463:
461:
460:
456:
455:body of uterus
452:
448:
444:
440:
436:
432:
428:
427:gastric mucosa
424:
420:
417:
416:
404:
403:
395:
384:
378:
377:
374:RNA expression
366:
365:
362:
361:
353:
349:
348:
340:
337:
332:
326:
325:
316:
309:
303:
299:
298:
293:
287:
286:
278:
277:
265:
264:
261:
260:
252:
248:
247:
239:
236:
231:
225:
224:
215:
208:
202:
198:
197:
190:
184:
183:
175:
174:
162:
161:
118:
114:
113:
105:
97:
96:
92:
91:
88:
87:
84:
83:
61:
60:
52:
51:
40:
34:
33:
25:
24:
21:
20:
9:
6:
4:
3:
2:
4326:
4315:
4312:
4310:
4307:
4305:
4302:
4301:
4299:
4288:
4283:
4281:
4276:
4274:
4269:
4268:
4262:
4260:
4256:
4252:
4251:chromosome 12
4248:
4243:
4240:
4236:
4235:
4231:
4225:
4220:
4215:
4214:
4211:
4197:
4193:
4192:
4187:
4184:
4180:
4179:
4174:
4171:
4167:
4166:
4161:
4158:
4154:
4153:
4148:
4145:
4141:
4140:
4135:
4132:
4128:
4127:
4122:
4119:
4115:
4114:
4109:
4108:
4106:
4102:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4072:
4070:
4066:
4060:
4057:
4055:
4054:Enzyme family
4052:
4050:
4047:
4045:
4042:
4041:
4039:
4035:
4029:
4026:
4024:
4021:
4019:
4018:Cooperativity
4016:
4014:
4011:
4010:
4008:
4004:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3977:Oxyanion hole
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3959:
3957:
3953:
3949:
3942:
3937:
3935:
3930:
3928:
3923:
3922:
3919:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3865:
3863:
3861:
3857:
3853:
3848:
3843:
3839:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3769:
3768:
3765:
3764:
3762:
3759:
3755:
3748:
3747:
3745:
3742:
3738:
3731:
3730:
3728:
3725:
3721:
3714:
3713:
3711:
3708:
3704:
3698:
3695:
3693:
3690:
3688:
3685:
3684:
3682:
3679:
3675:
3669:
3666:
3664:
3661:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3623:
3622:
3619:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3596:
3595:
3592:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3549:
3548:
3545:
3544:
3542:
3539:
3535:
3527:
3524:
3522:
3519:
3517:
3514:
3513:
3512:
3509:
3505:
3502:
3500:
3497:
3495:
3492:
3491:
3490:
3487:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3449:
3448:
3445:
3444:
3442:
3439:
3435:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3385:
3383:
3380:
3376:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3276:
3274:
3271:
3267:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3242:
3240:
3237:
3233:
3229:
3224:
3219:
3215:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3182:
3180:
3177:
3173:
3167:
3164:
3162:
3159:
3158:
3156:
3153:
3149:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3119:
3117:
3114:
3110:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3085:
3083:
3080:
3076:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2791:
2789:
2786:
2782:
2776:
2773:
2771:
2768:
2766:
2763:
2762:
2760:
2757:
2753:
2747:
2744:
2742:
2739:
2738:
2736:
2733:
2729:
2723:
2720:
2719:
2717:
2714:
2710:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2640:
2638:
2635:
2631:
2625:
2622:
2620:
2617:
2616:
2614:
2611:
2607:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2577:
2575:
2572:
2568:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2533:
2531:
2528:
2524:
2517:
2516:
2514:
2512:(EC 2.7.11.9)
2511:
2507:
2501:
2498:
2496:
2493:
2492:
2490:
2488:(EC 2.7.11.8)
2487:
2483:
2475:
2472:
2470:
2467:
2465:
2462:
2461:
2460:
2459:Aurora kinase
2457:
2456:
2454:
2452:(EC 2.7.11.7)
2451:
2447:
2441:
2438:
2437:
2435:
2433:(EC 2.7.11.6)
2432:
2428:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2403:
2401:
2399:(EC 2.7.11.5)
2398:
2394:
2388:
2385:
2383:
2380:
2378:
2375:
2374:
2372:
2370:(EC 2.7.11.4)
2369:
2365:
2357:
2354:
2352:
2349:
2347:
2344:
2343:
2341:
2337:
2334:
2332:
2329:
2328:
2326:
2322:
2319:
2317:
2314:
2313:
2311:
2308:
2307:
2305:
2303:(EC 2.7.11.3)
2302:
2298:
2292:
2289:
2287:
2284:
2282:
2279:
2277:
2274:
2273:
2271:
2269:(EC 2.7.11.2)
2268:
2264:
2256:
2253:
2252:
2251:
2248:
2244:
2241:
2239:
2236:
2234:
2231:
2229:
2226:
2225:
2224:
2223:EIF-2 kinases
2221:
2219:
2216:
2214:
2211:
2207:
2204:
2202:
2199:
2197:
2194:
2193:
2192:
2189:
2187:
2184:
2182:
2179:
2177:
2174:
2172:
2169:
2167:
2164:
2162:
2159:
2157:
2154:
2152:
2149:
2147:
2144:
2142:
2139:
2137:
2134:
2133:
2131:
2129:(EC 2.7.11.1)
2128:
2124:
2120:
2115:
2110:
2106:
2101:
2097:
2093:
2086:
2081:
2079:
2074:
2072:
2067:
2066:
2063:
2054:
2050:
2046:
2042:
2037:
2032:
2028:
2024:
2021:(6): 957–68.
2020:
2016:
2010:
2006:
2002:
1997:
1992:
1987:
1982:
1978:
1974:
1973:J. Biol. Chem
1970:
1965:
1961:
1957:
1952:
1947:
1943:
1939:
1938:J. Biol. Chem
1935:
1930:
1926:
1922:
1918:
1914:
1910:
1906:
1901:
1897:
1893:
1888:
1883:
1879:
1875:
1874:J. Biol. Chem
1871:
1866:
1862:
1858:
1853:
1848:
1844:
1840:
1839:J. Biol. Chem
1836:
1831:
1827:
1823:
1818:
1813:
1809:
1805:
1804:J. Biol. Chem
1801:
1796:
1792:
1788:
1783:
1778:
1774:
1770:
1766:
1761:
1757:
1753:
1748:
1743:
1739:
1735:
1731:
1726:
1722:
1718:
1713:
1708:
1704:
1700:
1699:J. Biol. Chem
1696:
1691:
1687:
1683:
1678:
1673:
1669:
1665:
1664:J. Biol. Chem
1661:
1656:
1652:
1648:
1643:
1638:
1634:
1630:
1629:J. Biol. Chem
1626:
1621:
1617:
1613:
1610:(3): 641–50.
1609:
1605:
1600:
1596:
1592:
1587:
1582:
1578:
1574:
1573:J. Biol. Chem
1570:
1565:
1561:
1557:
1552:
1547:
1543:
1539:
1535:
1530:
1529:
1515:
1511:
1506:
1501:
1497:
1493:
1489:
1485:
1481:
1474:
1472:
1470:
1468:
1466:
1464:
1462:
1453:
1449:
1444:
1439:
1435:
1431:
1430:J. Biol. Chem
1427:
1420:
1412:
1408:
1403:
1398:
1394:
1390:
1386:
1382:
1378:
1371:
1369:
1360:
1354:
1352:
1343:
1339:
1334:
1329:
1326:(1): 613–20.
1325:
1321:
1317:
1310:
1302:
1298:
1292:
1284:
1280:
1274:
1267:
1263:
1258:
1256:
1254:
1246:
1242:
1237:
1235:
1233:
1228:
1220:
1216:
1214:
1210:
1206:
1202:
1198:
1193:
1183:
1181:
1177:
1173:
1169:
1159:
1150:
1148:
1145:
1141:
1137:
1125:
1120:
1116:
1112:
1109:
1105:
1098:
1096:
1093:
1089:
1085:
1081:
1078:
1074:
1070:
1063:
1061:
1057:
1053:
1047:
1043:
1040:
1034:
1032:
1028:
1022:
1018:
1015:
1011:
1004:
1002:
998:
994:
988:
984:
981:
975:
973:
969:
963:
959:
956:
954:RefSeq (mRNA)
952:
945:
944:
939:
935:
932:
926:
925:
920:
916:
913:
911:
907:
900:
899:
894:
890:
887:
881:
880:
875:
871:
868:
866:
862:
855:
854:
849:
845:
842:
836:
835:
830:
826:
823:
821:
817:
814:
811:
809:
806:
802:
799:
795:
791:
784:
780:
775:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
674:
672:
669:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
603:
601:
598:
597:
594:
593:Gene ontology
590:
586:
574:
569:
565:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
483:
480:
476:
471:
468:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
396:
394:
393:
389:
388:
385:
383:
379:
375:
371:
367:
359:
354:
350:
346:
341:
335:15|15 F3
331:
327:
320:
313:
307:
300:
292:
288:
284:
279:
275:
270:
266:
258:
253:
249:
245:
240:
230:
226:
219:
212:
206:
199:
195:
189:
185:
181:
176:
172:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
115:
110:
103:
98:
93:
82:
80:
76:
72:
68:
62:
57:
54:
53:
49:
46:
39:
35:
30:
26:
22:
17:
4259:expanding it
4244:
4229:
4191:Translocases
4188:
4175:
4162:
4149:
4136:
4126:Transferases
4123:
4110:
3967:Binding site
3625:
3398:P70S6 kinase
2018:
2014:
1976:
1972:
1941:
1937:
1911:(3): 612–8.
1908:
1904:
1877:
1873:
1842:
1838:
1807:
1803:
1772:
1768:
1737:
1733:
1702:
1698:
1667:
1663:
1632:
1628:
1607:
1603:
1576:
1572:
1544:(2): 597–8.
1541:
1537:
1487:
1484:EMBO Reports
1483:
1433:
1429:
1419:
1384:
1380:
1323:
1319:
1309:
1300:
1291:
1282:
1273:
1217:
1189:
1165:
1162:Interactions
1156:
1143:
1135:
1134:
1060:NP_001345773
1052:NP_001157115
1049:
1027:NP_001180440
1024:
1001:NM_001358844
993:NM_001163643
990:
968:NM_001193511
965:
941:
922:
896:
877:
851:
832:
812:
807:
758:MAPK cascade
497:otic placode
489:aortic valve
397:
390:
356:102,425,499
343:102,406,081
117:External IDs
64:
3962:Active site
3849:(EC 2.7.12)
3236:Polo kinase
3176:Polo kinase
733:JNK cascade
692:growth cone
641:ATP binding
435:right ovary
255:53,500,063
242:53,479,669
95:Identifiers
4298:Categories
4165:Isomerases
4139:Hydrolases
4006:Regulation
2527:IÎşB kinase
2102:2.7.11-12)
1268:, May 2017
1247:, May 2017
1223:References
1197:hypoplasia
459:left ovary
401:(ortholog)
138:HomoloGene
4309:EC 2.7.11
4249:on human
4044:EC number
2653:PKC alpha
1209:apoptosis
1056:NP_033608
1031:NP_006292
997:NM_009582
972:NM_006301
798:Orthologs
677:cytoplasm
146:GeneCards
4068:Kinetics
3992:Cofactor
3955:Activity
3009:KIAA0999
2904:MAPKAPK5
2899:MAPKAPK3
2894:MAPKAPK2
2045:16169070
2005:15695824
1960:15611134
1925:14697235
1896:14504284
1861:10922377
1826:10801814
1791:10490457
1756:10442638
1734:Oncogene
1721:10187804
1604:Oncogene
1538:Genomics
1514:23681442
1452:10187804
1411:10490659
1264:–
1243:–
1201:cingulum
1180:MAPK8IP2
1172:MAPK8IP1
1168:interact
1153:Function
1108:Wikidata
777:Sources:
687:membrane
234:12q13.13
4224:Biology
4178:Ligases
3948:Enzymes
3668:MAP3K14
3646:MAP3K11
3641:MAP3K10
3631:MAP3K13
3626:MAP3K12
3428:RPS6KC1
3423:RPS6KA1
3418:RPS6KA3
3413:RPS6KA2
3408:RPS6KB2
3393:RPS6KA4
3388:RPS6KA5
3039:Kalirin
3004:SNF1LK2
2243:EIF2AK4
2238:EIF2AK3
2092:Kinases
2053:8235923
1686:9353328
1651:8663324
1616:8637721
1595:7983011
1560:7790002
1505:3701236
1342:8037767
1266:Ensembl
1245:Ensembl
1144:MAP3K12
910:UniProt
865:Ensembl
804:Species
783:QuickGO
682:cytosol
376:pattern
150:MAP3K12
134:1346881
109:MAP3K12
102:Aliases
19:MAP3K12
4210:Portal
4152:Lyases
3898:MAP2K7
3893:MAP2K6
3888:MAP2K5
3883:MAP2K4
3878:MAP2K3
3873:MAP2K2
3868:MAP2K1
3819:ACVRL1
3814:ACVR2B
3809:ACVR2A
3804:ACVR1C
3799:ACVR1B
3782:BMPR1B
3777:BMPR1A
3651:MAP3K7
3636:MAP3K9
3587:MAP3K8
3582:MAP3K7
3577:MAP3K6
3572:MAP3K5
3567:MAP3K4
3562:MAP3K3
3557:MAP3K2
3552:MAP3K1
3526:MAPK14
3521:MAPK13
3516:MAPK11
3504:MAPK10
3482:MAPK15
3477:MAPK12
3369:CDC2L1
3344:CDC2L5
3019:SNF1LK
2844:CAMK2G
2839:CAMK2D
2834:CAMK2B
2829:CAMK2A
2819:CAMK1G
2814:CAMK1D
2809:CAMK1B
2804:CAMK1A
2658:PRKCB1
2595:PRKACA
2590:PRKACB
2585:PRKACG
2561:IKBKAP
2387:BCKDHB
2382:BCKDHA
2356:PRKAG3
2351:PRKAG2
2346:PRKAG1
2336:PRKAB2
2331:PRKAB1
2321:PRKAA2
2316:PRKAA1
2161:STK38L
2051:
2043:
2003:
1958:
1923:
1894:
1859:
1824:
1789:
1754:
1719:
1684:
1649:
1614:
1593:
1558:
1512:
1502:
1450:
1409:
1399:
1340:
1176:MAP2K7
1140:enzyme
1138:is an
1094:search
1092:PubMed
943:Q60700
924:Q12852
820:Entrez
547:BioGPS
126:600447
4253:is a
4104:Types
3860:MAP2K
3794:ACVR1
3787:BMPR2
3772:BMPR1
3697:GSK-3
3538:MAP3K
3499:MAPK9
3494:MAPK8
3472:MAPK7
3467:MAPK6
3462:MAPK4
3457:MAPK3
3452:MAPK1
3364:PFTK1
3359:PCTK3
3354:PCTK2
3349:PCTK1
3339:CDK12
3334:CDK10
3309:CDKL5
3289:CDKL2
3166:STK19
3161:EEF2K
3142:PHKG2
3137:PHKG1
3127:PHKA2
3122:PHKA1
3103:MYLK4
3098:MYLK3
3093:MYLK2
3069:DCLK1
3064:Titin
3054:TRIB3
3049:TRIB2
3044:TRIB1
3034:TSSK2
3014:STK40
2999:PSKH1
2994:PRKD3
2989:PRKD2
2969:PHKG2
2964:PHKG1
2954:OBSCN
2949:NUAK2
2944:NUAK1
2939:MKNK2
2934:MKNK1
2924:MARK4
2919:MARK3
2914:MARK2
2909:MARK1
2889:STK11
2884:DAPK3
2879:DAPK2
2874:DAPK1
2869:CHEK2
2864:CHEK1
2849:CAMK4
2824:CAMK2
2799:CAMK1
2794:BRSK2
2688:PRKCQ
2683:PRKCI
2678:PRKCG
2673:PRKCH
2668:PRKCE
2663:PRKCD
2624:PRKG1
2556:IKBKG
2551:IKBKE
2500:STK10
2495:FASTK
2421:IDH3G
2416:IDH3B
2411:IDH3A
2377:BCKDK
2171:ROCK1
2156:STK38
2151:MAST2
2146:MAST1
2141:LATS2
2136:LATS1
2049:S2CID
1402:84717
1170:with
853:26404
813:Mouse
808:Human
779:Amigo
399:Mouse
392:Human
339:Start
274:Mouse
238:Start
171:Human
4255:stub
4247:gene
4196:list
4189:EC7
4183:list
4176:EC6
4170:list
4163:EC5
4157:list
4150:EC4
4144:list
4137:EC3
4131:list
4124:EC2
4118:list
4111:EC1
3687:TPK1
3663:CDC7
3621:MLKs
3614:KSR2
3609:KSR1
3604:BRAF
3599:ARAF
3594:RAFs
3329:CDK9
3324:CDK8
3319:CDK7
3314:CDK6
3304:CDK5
3299:CDK4
3294:CDK3
3284:CDK2
3279:CDK1
3260:PLK4
3255:PLK3
3250:PLK2
3245:PLK1
3200:PLK4
3195:PLK3
3190:PLK2
3185:PLK1
3132:PHKB
3088:MYLK
3059:TRIO
3029:SPEG
3024:SNRK
2984:PKD1
2979:PIM2
2974:PIM1
2959:PASK
2929:MELK
2859:CASK
2854:MLCK
2775:GRK6
2770:GRK5
2765:GRK4
2703:PKN3
2698:PKN2
2600:PRKY
2546:TBK1
2541:IKK2
2536:CHUK
2440:STK4
2406:IDH2
2291:PDK4
2286:PDK3
2281:PDK2
2276:PDK1
2255:WEE1
2250:Wee1
2218:mTOR
2206:AKT3
2201:AKT2
2196:AKT1
2186:SGK3
2181:SGK2
2041:PMID
2015:Cell
2001:PMID
1956:PMID
1921:PMID
1892:PMID
1857:PMID
1822:PMID
1787:PMID
1752:PMID
1717:PMID
1682:PMID
1647:PMID
1612:PMID
1591:PMID
1556:PMID
1510:PMID
1448:PMID
1407:PMID
1338:PMID
1203:and
1178:and
1147:gene
834:7786
702:axon
382:Bgee
330:Band
291:Chr.
229:Band
188:Chr.
142:4592
122:OMIM
79:5CEO
75:5CEQ
71:5CEP
67:5CEN
48:RCSB
45:PDBe
3692:TTK
3656:ZAK
2233:HRI
2228:PKR
2176:SGK
2166:CIT
2031:hdl
2023:doi
2019:122
1991:hdl
1981:doi
1977:280
1946:doi
1942:280
1913:doi
1909:313
1882:doi
1878:278
1847:doi
1843:275
1812:doi
1808:275
1777:doi
1742:doi
1707:doi
1703:274
1672:doi
1668:272
1637:doi
1633:271
1581:doi
1577:269
1546:doi
1500:PMC
1492:doi
1438:doi
1434:274
1397:PMC
1389:doi
1328:doi
1324:202
1213:NGF
352:End
251:End
154:OMA
130:MGI
38:PDB
4300::
2342:Îł
2327:β
2312:α
2100:EC
2094::
2047:.
2039:.
2029:.
2017:.
1999:.
1989:.
1975:.
1971:.
1954:.
1940:.
1936:.
1919:.
1907:.
1890:.
1876:.
1872:.
1855:.
1841:.
1837:.
1820:.
1806:.
1802:.
1785:.
1773:47
1771:.
1767:.
1750:.
1738:18
1736:.
1732:.
1715:.
1701:.
1697:.
1680:.
1666:.
1662:.
1645:.
1631:.
1627:.
1608:12
1606:.
1589:.
1575:.
1571:.
1554:.
1542:25
1540:.
1536:.
1508:.
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