456:
433:
355:
330:
2832:
707:
35:
462:
361:
5009:
61:
1570:
intermediates to increase. Despite the normal activity of MEK1 in reducing inter-sister chromatid recombination, such recombination still occurs frequently during normal budding yeast meiosis (although not as frequently as during
469:
368:
1551:
are efficiently repaired by inter-sister chromatid recombination. This recombination occurs with the same timing as inter-homolog recombination, but with reduced (2- to 3-fold) yields of joint molecules.
2831:
2872:
1717:
Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5".
3157:
2297:"p38α Isoform Mxi2 Binds to Extracellular Signal-Regulated Kinase 1 and 2 Mitogen-Activated Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels"
1547:. Molecular-level studies of recombination during budding yeast meiosis have shown that recombination events initiated by DSBs in regions that lack corresponding sequences in the
2084:"Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells"
1996:
Schaeffer, H J; Catling A D; Eblen S T; Collier L S; Krauss A; Weber M J (Sep 1998). "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade".
2671:
Tanaka S, Nakamura K, Takahasi N, Suda T (2006). "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system".
2865:
1491:
and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the
1190:
2858:
1171:
291:
3065:
2207:"A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways"
4410:
1699:
1681:
4452:
3613:
2916:
1944:"A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment"
4561:
3299:
3186:
1592:
1390:
3574:
2248:"JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway"
2515:"Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle"
1397:
4547:
4366:
4012:
3608:
3598:
3593:
2903:
2885:
4649:
4530:
1803:
1556:
1472:
20:
4236:
3105:
1476:
5029:
4300:
3275:
2811:
1664:
4556:
2246:
Ito, M; Yoshioka K; Akechi M; Yamashita S; Takamatsu N; Sugiyama K; Hibi M; Nakabeppu Y; Shiba T; Yamamoto K I (Nov 1999).
1892:"Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein"
1764:"Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2"
58:
3090:
1643:
4288:
4613:
4728:
3545:
3535:
3220:
2850:
1836:"Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis"
455:
4227:
2840:: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
4496:
4168:
3530:
3521:
1668:
1647:
432:
1235:
1559:). MEK1 is a meiotic chromosome-axis-associated kinase that is thought to slow down, but not entirely block,
4884:
3911:
3408:
3399:
3056:
3002:
354:
329:
2166:"Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases"
1216:
3099:
2779:
271:
1471:
The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a
1584:
468:
367:
4999:
4123:
3941:
3437:
2558:"Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation"
461:
360:
2387:"Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking"
4985:
4972:
4959:
4946:
4933:
4920:
4907:
4869:
4113:
4108:
4103:
4093:
4088:
4083:
4073:
3868:
3643:
3239:
2804:
1540:
1942:
Wunderlich, W; Fialka I; Teis D; Alpi A; Pfeifer A; Parton R G; Lottspeich F; Huber L A (Feb 2001).
258:
4879:
4833:
4776:
4336:
4327:
4278:
3044:
2889:
1504:
1500:
279:
2082:
Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (Jan 1997).
4781:
4636:
4059:
2125:"Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2"
1539:
double-strand breaks (DSBs) that form within such polymorphic regions must be repaired by inter-
1373:
1352:
1326:
1305:
1524:
1480:
2642:
Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection".
4802:
4721:
3335:
1563:
1548:
1544:
343:
299:
4874:
3902:
2797:
2007:
1528:
2346:"Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1"
2343:
8:
4838:
4011:
2428:"Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2"
1532:
2902:
2011:
5034:
4771:
4513:
4467:
2696:
2630:
2539:
2514:
1968:
1943:
1862:
1835:
303:
2582:
2557:
2513:
Wu J, Michel H, Rossomando A, Haystead T, Shabanowitz J, Hunt DF, Sturgill TW (1992).
2321:
2296:
2182:
2165:
1890:
Yeung, K; Janosch P; McFerran B; Rose D W; Mischak H; Sedivy J M; Kolch W (May 2000).
1817:
1780:
1763:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
3773:
3482:
2880:
2760:
2725:
2688:
2684:
2659:
2622:
2587:
2544:
2490:
2449:
2408:
2367:
2344:
Robinson, Fred L; Whitehurst
Angelique W; Raman Malavika; Cobb Melanie H (Apr 2002).
2326:
2277:
2272:
2247:
2228:
2187:
2146:
2105:
2064:
2023:
1998:
1973:
1921:
1916:
1891:
1867:
1785:
1744:
1567:
251:
51:
2700:
2634:
2573:
2312:
1907:
283:
4817:
4812:
4786:
4714:
3511:
3502:
3432:
3423:
3369:
3360:
3017:
2750:
2717:
2680:
2651:
2612:
2577:
2569:
2534:
2526:
2480:
2439:
2398:
2357:
2316:
2308:
2267:
2259:
2218:
2177:
2136:
2095:
2054:
2015:
1963:
1955:
1911:
1903:
1857:
1847:
1775:
1734:
1726:
1560:
1492:
548:
479:
423:
378:
2019:
1575:), and up to one-third of all recombination events are between sister chromatids.
262:, CFC3, MAPKK1, MEK1, MKK1, PRKMK1, mitogen-activated protein kinase kinase 1, MEL
4864:
4848:
4761:
4192:
3263:
3258:
3253:
1852:
523:
307:
1704:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1686:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5013:
4902:
4843:
2721:
2617:
2600:
1061:
positive regulation of production of miRNAs involved in gene silencing by miRNA
624:
2784:
5023:
4807:
4766:
3248:
2655:
2205:
Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (Dec 2000).
2059:
2042:
1615:
735:
706:
3316:
684:
562:
4756:
4187:
3012:
2764:
2729:
2692:
2663:
2494:
2485:
2468:
2453:
2444:
2427:
2412:
2403:
2386:
2371:
2362:
2345:
2330:
2281:
2263:
2232:
2223:
2206:
2141:
2124:
2100:
2083:
1977:
1925:
1871:
541:
320:
2626:
2591:
2548:
2191:
2150:
2109:
2068:
2027:
1959:
1789:
1748:
1437:
1432:
34:
4980:
4915:
4751:
4393:
4025:
3965:
3848:
3768:
3492:
2755:
2738:
2043:"Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases"
1739:
1496:
1488:
1280:
1261:
1995:
4481:
2955:
2041:
Nantel, A; Mohammad-Ali K; Sherk J; Posner B I; Thomas D Y (Apr 1998).
1520:
440:
337:
287:
2530:
1730:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
4954:
4928:
3442:
2739:"ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts"
2040:
1596:
1135:
507:
494:
406:
393:
295:
2708:
Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects".
1566:. Loss of MEK1 allows inter-sister DSB repair and also inter-sister
5008:
3798:
3693:
3688:
3683:
1608:
1421:
3158:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2384:
2294:
2204:
1507:
and development. MAP2K1 is altered in 1.05% of all human cancers.
4457:
4435:
4430:
4420:
4415:
4217:
4212:
4207:
4202:
4197:
4182:
4177:
3828:
3793:
3032:
3027:
3022:
1572:
1536:
1247:
1202:
1120:
1116:
2245:
1889:
275:
4967:
4737:
4687:
4682:
4677:
4672:
4667:
4662:
4608:
4603:
4598:
4593:
4588:
4571:
4566:
4440:
4425:
4376:
4371:
4356:
4351:
4346:
4341:
4315:
4310:
4305:
4293:
4271:
4266:
4158:
4133:
3808:
3633:
3628:
3623:
3618:
3603:
3447:
3384:
3379:
3374:
3350:
3176:
3171:
3145:
3140:
3135:
3125:
3120:
3110:
2950:
2881:
1804:"Entrez Gene: MAP2K1 mitogen-activated protein kinase kinase 1"
1619:
1516:
1484:
1453:
1405:
1157:
916:
positive regulation of protein serine/threonine kinase activity
715:
2789:
2785:
1941:
1716:
4941:
4583:
4576:
4486:
4383:
4283:
4261:
4256:
4251:
4246:
4241:
4153:
4148:
4143:
4138:
4128:
4098:
4078:
3955:
3950:
3931:
3926:
3916:
3892:
3887:
3882:
3858:
3853:
3843:
3838:
3833:
3823:
3803:
3788:
3783:
3778:
3758:
3753:
3743:
3738:
3733:
3728:
3723:
3713:
3708:
3703:
3698:
3678:
3673:
3668:
3663:
3658:
3653:
3638:
3588:
3583:
3477:
3472:
3467:
3462:
3457:
3452:
3413:
3345:
3340:
3289:
3284:
3210:
3205:
3200:
3166:
2960:
2945:
2940:
2935:
2930:
2925:
2555:
2295:
Sanz-Moreno, Victoria; Casar Berta; Crespo Piero (May 2003).
1612:
1604:
1600:
1588:
1495:, this kinase is involved in many cellular processes such as
2081:
976:
epithelial cell proliferation involved in lung morphogenesis
4476:
4403:
4398:
4388:
4361:
4118:
4068:
4049:
4044:
4039:
4034:
3989:
3984:
3979:
3974:
3921:
3877:
3818:
3813:
3763:
3748:
3718:
3648:
3564:
3559:
3554:
3487:
3389:
3330:
3325:
3229:
3195:
3080:
3075:
3070:
3039:
3007:
2995:
2990:
2985:
2975:
2970:
2737:
Galabova-Kovacs G, Kolbus A, Matzen D, et al. (2006).
2736:
1460:
4706:
2670:
2512:
1450:
Dual specificity mitogen-activated protein kinase kinase 1
4445:
2980:
2965:
2385:
Xu Be, Be; Stippec S; Robinson F L; Cobb M H (Jul 2001).
4635:
531:
2556:
Rossomando AJ, Dent P, Sturgill TW, Marshak DR (1994).
1011:
regulation of early endosome to late endosome transport
2466:
4997:
696:
936:
negative regulation of cell population proliferation
2469:"MEKK1 binds raf-1 and the ERK2 cascade components"
1071:
positive regulation of transcription, DNA-templated
635:
dentate gyrus of hippocampal formation granule cell
1660:
1658:
1656:
1639:
1637:
1635:
774:protein serine/threonine kinase activator activity
1101:stress-activated protein kinase signaling cascade
784:protein serine/threonine/tyrosine kinase activity
478:
377:
5021:
2780:GeneReviews/NCBI/NIH/UW entry on Noonan syndrome
2641:
2707:
1937:
1935:
1885:
1883:
1881:
1833:
1653:
1632:
1483:for multiple biochemical signals. This protein
16:Protein-coding gene in the species Homo sapiens
1991:
1989:
1987:
1665:GRCm38: Ensembl release 89: ENSMUSG00000004936
4722:
2917:Non-specific serine/threonine protein kinases
2866:
2805:
2163:
2122:
1473:mitogen-activated protein (MAP) kinase kinase
2460:
2425:
2419:
2378:
2337:
2288:
2239:
2198:
1932:
1878:
1523:organisms in natural populations are highly
1066:positive regulation of ERK1 and ERK2 cascade
2157:
2116:
2075:
2034:
1984:
1644:GRCh38: Ensembl release 89: ENSG00000169032
966:regulation of stress-activated MAPK cascade
961:positive regulation of cell differentiation
4729:
4715:
3300:Goodpasture-antigen-binding protein kinase
2873:
2859:
2812:
2798:
2598:
2467:Karandikar, M; Xu S; Cobb M H (Dec 2000).
1829:
1827:
1755:
1710:
1593:Phosphatidylethanolamine binding protein 1
605:Skeletal muscle tissue of rectus abdominis
4013:Serine/threonine-specific protein kinases
3187:(isocitrate dehydrogenase (NADP+)) kinase
2904:Serine/threonine-specific protein kinases
2886:Serine/threonine-specific protein kinases
2754:
2616:
2581:
2538:
2484:
2443:
2402:
2361:
2320:
2271:
2222:
2181:
2140:
2099:
2058:
1967:
1915:
1861:
1851:
1779:
1761:
1738:
4548:Receptor protein serine/threonine kinase
809:protein serine/threonine kinase activity
4531:Low-density-lipoprotein receptor kinase
1824:
1557:Mitogen-activated protein kinase kinase
21:Mitogen-activated protein kinase kinase
5022:
1493:MAP kinase signal transduction pathway
1477:extracellular signal-regulated kinases
1036:positive regulation of gene expression
951:negative regulation of gene expression
4710:
4634:
4010:
3276:Fas-activated serine/threonine kinase
2901:
2854:
2793:
1106:activation of protein kinase activity
906:regulation of protein phosphorylation
483:
444:
439:
382:
341:
336:
4648:
4557:Bone morphogenetic protein receptors
3091:Dephospho-(reductase kinase) kinase
1041:Bergmann glial cell differentiation
911:positive regulation of axonogenesis
13:
3546:G-protein coupled receptor kinases
2505:
1555:MAP2K1 is also known as MEK1 (see
1091:peptidyl-threonine phosphorylation
14:
5046:
3536:Beta adrenergic receptor kinase-2
3221:(tyrosine 3-monooxygenase) kinase
2773:
2164:Zheng, C F; Guan K L (Nov 1993).
2123:Butch, E R; Guan K L (Feb 1996).
1456:that in humans is encoded by the
1046:peptidyl-tyrosine phosphorylation
1021:placenta blood vessel development
5007:
4228:Mitogen-activated protein kinase
2830:
2685:10.1111/j.0105-2896.2005.00327.x
2006:(5383). UNITED STATES: 1668–71.
1076:regulation of mitotic cell cycle
789:protein tyrosine kinase activity
705:
467:
460:
454:
431:
366:
359:
353:
328:
33:
4614:Anti-Müllerian hormone receptor
4497:(acetyl-CoA carboxylase) kinase
4169:(RNA-polymerase)-subunit kinase
3531:Beta adrenergic receptor kinase
3522:Beta adrenergic receptor kinase
2819:
2574:10.1128/mcb.14.3.1594-1602.1994
2397:(28). United States: 26509–15.
2356:(17). United States: 14844–52.
2313:10.1128/MCB.23.9.3079-3090.2003
2053:(17). UNITED STATES: 10475–84.
1908:10.1128/MCB.20.9.3079-3085.2000
1578:
1081:regulation of apoptotic process
1051:regulation of Golgi inheritance
1001:regulation of axon regeneration
4237:Extracellular signal-regulated
2479:(51). UNITED STATES: 40120–7.
2438:(19). United States: 16070–5.
2426:Chen, Z; Cobb M H (May 2001).
2258:(11). UNITED STATES: 7539–48.
2217:(51). UNITED STATES: 39815–8.
2176:(32). UNITED STATES: 23933–9.
1834:Goldfarb T, Lichten M (2010).
1810:
1796:
1762:Zheng CF, Guan KL (Jun 1993).
1692:
1674:
1016:labyrinthine layer development
716:More reference expression data
685:More reference expression data
1:
4301:P38 mitogen-activated protein
3400:cGMP-dependent protein kinase
3361:cAMP-dependent protein kinase
3057:Pyruvate dehydrogenase kinase
3003:Ataxia telangiectasia mutated
2307:(9). United States: 3079–90.
2183:10.1016/S0021-9258(20)80474-8
2020:10.1126/science.281.5383.1668
1902:(9). UNITED STATES: 3079–85.
1781:10.1016/S0021-9258(18)82142-1
1625:
1475:. MAP kinases, also known as
840:microtubule organizing center
452:
351:
5030:Genes on human chromosome 15
3100:AMP-activated protein kinase
2601:"The MAPK signaling cascade"
2135:(8). UNITED STATES: 4230–5.
2094:(5). UNITED STATES: 2620–8.
1954:(4). United States: 765–76.
1853:10.1371/journal.pbio.1000520
1026:keratinocyte differentiation
7:
4736:
4015:(EC 2.7.11.21-EC 2.7.11.30)
1818:"MAP2K1 - My Cancer Genome"
1466:
931:cerebellar cortex formation
10:
5051:
3942:Elongation factor 2 kinase
2906:(EC 2.7.11.1-EC 2.7.11.20)
2722:10.2174/157016206775197583
2618:10.1096/fasebj.9.9.7601337
2599:Seger R, Krebs EG (1995).
1510:
799:MAP kinase kinase activity
759:protein C-terminus binding
749:protein N-terminus binding
18:
4893:
4885:Michaelis–Menten kinetics
4857:
4826:
4795:
4744:
4644:
4630:
4546:
4529:
4512:
4495:
4466:
4337:MAP kinase kinase kinases
4326:
4226:
4167:
4058:
4024:
4020:
4006:
3964:
3940:
3901:
3869:Myosin light-chain kinase
3867:
3575:Ca2+/calmodulin-dependent
3573:
3544:
3520:
3501:
3422:
3398:
3359:
3315:
3298:
3274:
3240:Myosin-heavy-chain kinase
3238:
3219:
3185:
3156:
3089:
3055:
2915:
2911:
2897:
2825:
1700:"Mouse PubMed Reference:"
1682:"Human PubMed Reference:"
1583:MAP2K1 has been shown to
1541:sister chromatid exchange
1436:
1431:
1427:
1420:
1404:
1385:
1370:
1366:
1349:
1345:
1338:
1323:
1319:
1302:
1298:
1291:
1278:
1274:
1259:
1255:
1246:
1233:
1229:
1214:
1210:
1201:
1188:
1184:
1169:
1165:
1156:
1141:
1134:
1130:
1114:
986:thyroid gland development
734:
730:
713:
704:
695:
682:
631:
622:
569:
560:
530:
522:
518:
501:
488:
451:
430:
421:
417:
400:
387:
350:
327:
318:
314:
269:
266:
256:
249:
244:
77:
72:
55:
50:
45:
41:
32:
27:
4777:Diffusion-limited enzyme
4637:Dual-specificity kinases
2656:10.2174/1570162052773013
2060:10.1074/jbc.273.17.10475
1505:transcription regulation
1391:Chr 15: 66.39 – 66.49 Mb
814:scaffold protein binding
4060:Cyclin-dependent kinase
1398:Chr 9: 64.09 – 64.16 Mb
1086:protein phosphorylation
804:protein kinase activity
2486:10.1074/jbc.M005926200
2445:10.1074/jbc.M100681200
2404:10.1074/jbc.M102769200
2363:10.1074/jbc.M107776200
2264:10.1128/mcb.19.11.7539
2224:10.1074/jbc.C000403200
2142:10.1074/jbc.271.8.4230
2101:10.1074/jbc.272.5.2620
1545:inter-homolog exchange
991:neuron differentiation
647:superior frontal gyrus
597:superior frontal gyrus
4870:Eadie–Hofstee diagram
4803:Allosteric regulation
1960:10.1083/jcb.152.4.765
1096:ERK1 and ERK2 cascade
860:endoplasmic reticulum
671:primary visual cortex
344:Chromosome 15 (human)
4880:Lineweaver–Burk plot
3903:Phosphorylase kinase
2756:10.4161/cc.5.14.2981
1719:Cytogenet Cell Genet
769:transferase activity
577:orbitofrontal cortex
446:Chromosome 9 (mouse)
73:List of PDB id codes
46:Available structures
2012:1998Sci...281.1668S
1056:signal transduction
921:cellular senescence
485:9 C|9 34.55 cM
4839:Enzyme superfamily
4772:Enzyme promiscuity
4514:Tropomyosin kinase
4468:Tau-protein kinase
1479:(ERKs), act as an
1236:ENSMUSG00000004936
1006:lung morphogenesis
941:thymus development
899:Biological process
823:Cellular component
794:nucleotide binding
742:Molecular function
655:hippocampus proper
639:olfactory tubercle
308:MAP2K1 - orthologs
4995:
4994:
4704:
4703:
4700:
4699:
4696:
4695:
4626:
4625:
4622:
4621:
4002:
4001:
3998:
3997:
3483:Protein kinase N1
3438:Protein kinase Cζ
2848:
2847:
2531:10.1042/bj2850701
1731:10.1159/000134677
1568:Holliday junction
1543:, rather than by
1487:lies upstream of
1481:integration point
1447:
1446:
1443:
1442:
1416:
1415:
1381:
1380:
1360:
1359:
1334:
1333:
1313:
1312:
1287:
1286:
1268:
1267:
1242:
1241:
1223:
1222:
1197:
1196:
1178:
1177:
1126:
1125:
996:trachea formation
956:heart development
726:
725:
722:
721:
691:
690:
678:
677:
643:nucleus accumbens
616:
615:
601:nucleus accumbens
585:postcentral gyrus
581:prefrontal cortex
514:
513:
413:
412:
240:
239:
236:
235:
56:Ortholog search:
5042:
5012:
5011:
5003:
4875:Hanes–Woolf plot
4818:Enzyme activator
4813:Enzyme inhibitor
4787:Enzyme catalysis
4731:
4724:
4717:
4708:
4707:
4646:
4645:
4632:
4631:
4279:C-Jun N-terminal
4022:
4021:
4008:
4007:
3512:Rhodopsin kinase
3503:Rhodopsin kinase
3433:Protein kinase C
3424:Protein kinase C
3409:Protein kinase G
3370:Protein kinase A
2981:Protein kinase B
2913:
2912:
2899:
2898:
2875:
2868:
2861:
2852:
2851:
2834:
2814:
2807:
2800:
2791:
2790:
2768:
2758:
2733:
2704:
2667:
2638:
2620:
2595:
2585:
2552:
2542:
2499:
2498:
2488:
2464:
2458:
2457:
2447:
2423:
2417:
2416:
2406:
2382:
2376:
2375:
2365:
2341:
2335:
2334:
2324:
2292:
2286:
2285:
2275:
2243:
2237:
2236:
2226:
2202:
2196:
2195:
2185:
2161:
2155:
2154:
2144:
2120:
2114:
2113:
2103:
2079:
2073:
2072:
2062:
2038:
2032:
2031:
1993:
1982:
1981:
1971:
1939:
1930:
1929:
1919:
1887:
1876:
1875:
1865:
1855:
1846:(10): e1000520.
1831:
1822:
1821:
1814:
1808:
1807:
1800:
1794:
1793:
1783:
1759:
1753:
1752:
1742:
1714:
1708:
1707:
1696:
1690:
1689:
1678:
1672:
1662:
1651:
1641:
1561:sister chromatid
1429:
1428:
1400:
1393:
1376:
1364:
1363:
1355:
1343:
1342:
1339:RefSeq (protein)
1329:
1317:
1316:
1308:
1296:
1295:
1272:
1271:
1253:
1252:
1227:
1226:
1208:
1207:
1182:
1181:
1163:
1162:
1132:
1131:
926:face development
732:
731:
718:
709:
702:
701:
687:
659:secondary oocyte
627:
625:Top expressed in
620:
619:
589:Brodmann area 46
573:secondary oocyte
565:
563:Top expressed in
558:
557:
537:
536:
520:
519:
510:
497:
486:
471:
464:
458:
447:
435:
419:
418:
409:
396:
385:
370:
363:
357:
346:
332:
316:
315:
310:
261:
254:
231:
70:
69:
64:
43:
42:
37:
25:
24:
5050:
5049:
5045:
5044:
5043:
5041:
5040:
5039:
5020:
5019:
5018:
5006:
4998:
4996:
4991:
4903:Oxidoreductases
4889:
4865:Enzyme kinetics
4853:
4849:List of enzymes
4822:
4791:
4762:Catalytic triad
4740:
4735:
4705:
4692:
4640:
4618:
4542:
4525:
4508:
4491:
4462:
4322:
4222:
4193:P70-S6 Kinase 1
4163:
4054:
4016:
3994:
3960:
3936:
3897:
3863:
3569:
3540:
3516:
3497:
3418:
3394:
3355:
3311:
3294:
3270:
3264:Aurora C kinase
3259:Aurora B kinase
3254:Aurora A kinase
3234:
3215:
3181:
3152:
3085:
3051:
2907:
2893:
2879:
2849:
2844:
2841:
2835:
2821:
2818:
2776:
2771:
2568:(3): 1594–602.
2508:
2506:Further reading
2503:
2502:
2465:
2461:
2424:
2420:
2383:
2379:
2342:
2338:
2301:Mol. Cell. Biol
2293:
2289:
2252:Mol. Cell. Biol
2244:
2240:
2203:
2199:
2162:
2158:
2121:
2117:
2080:
2076:
2039:
2035:
1994:
1985:
1940:
1933:
1896:Mol. Cell. Biol
1888:
1879:
1832:
1825:
1816:
1815:
1811:
1802:
1801:
1797:
1774:(15): 11435–9.
1760:
1756:
1715:
1711:
1698:
1697:
1693:
1680:
1679:
1675:
1663:
1654:
1642:
1633:
1628:
1581:
1513:
1501:differentiation
1469:
1438:View/Edit Mouse
1433:View/Edit Human
1396:
1389:
1386:Location (UCSC)
1372:
1351:
1325:
1304:
1217:ENSG00000169032
1110:
971:phosphorylation
894:
890:plasma membrane
870:Golgi apparatus
818:
779:protein binding
754:kinase activity
714:
683:
674:
669:
665:
661:
657:
653:
649:
645:
641:
637:
623:
612:
609:cingulate gyrus
607:
603:
599:
595:
593:Brodmann area 9
591:
587:
583:
579:
575:
561:
505:
492:
484:
474:
473:
472:
465:
445:
422:Gene location (
404:
391:
383:
373:
372:
371:
364:
342:
319:Gene location (
270:
257:
250:
79:
57:
23:
17:
12:
11:
5:
5048:
5038:
5037:
5032:
5017:
5016:
4993:
4992:
4990:
4989:
4976:
4963:
4950:
4937:
4924:
4911:
4897:
4895:
4891:
4890:
4888:
4887:
4882:
4877:
4872:
4867:
4861:
4859:
4855:
4854:
4852:
4851:
4846:
4841:
4836:
4830:
4828:
4827:Classification
4824:
4823:
4821:
4820:
4815:
4810:
4805:
4799:
4797:
4793:
4792:
4790:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4748:
4746:
4742:
4741:
4734:
4733:
4726:
4719:
4711:
4702:
4701:
4698:
4697:
4694:
4693:
4691:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4654:
4652:
4642:
4641:
4628:
4627:
4624:
4623:
4620:
4619:
4617:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4580:
4579:
4574:
4569:
4564:
4553:
4551:
4550:(EC 2.7.11.30)
4544:
4543:
4541:
4540:
4536:
4534:
4533:(EC 2.7.11.29)
4527:
4526:
4524:
4523:
4519:
4517:
4516:(EC 2.7.11.28)
4510:
4509:
4507:
4506:
4502:
4500:
4499:(EC 2.7.11.27)
4493:
4492:
4490:
4489:
4484:
4479:
4473:
4471:
4470:(EC 2.7.11.26)
4464:
4463:
4461:
4460:
4455:
4450:
4449:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4408:
4407:
4406:
4401:
4396:
4391:
4381:
4380:
4379:
4374:
4369:
4364:
4359:
4354:
4349:
4344:
4333:
4331:
4330:(EC 2.7.11.25)
4324:
4323:
4321:
4320:
4319:
4318:
4313:
4308:
4298:
4297:
4296:
4291:
4286:
4276:
4275:
4274:
4269:
4264:
4259:
4254:
4249:
4244:
4233:
4231:
4230:(EC 2.7.11.24)
4224:
4223:
4221:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4174:
4172:
4171:(EC 2.7.11.23)
4165:
4164:
4162:
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4126:
4121:
4116:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4065:
4063:
4062:(EC 2.7.11.22)
4056:
4055:
4053:
4052:
4047:
4042:
4037:
4031:
4029:
4028:(EC 2.7.11.21)
4018:
4017:
4004:
4003:
4000:
3999:
3996:
3995:
3993:
3992:
3987:
3982:
3977:
3971:
3969:
3968:(EC 2.7.11.21)
3962:
3961:
3959:
3958:
3953:
3947:
3945:
3944:(EC 2.7.11.20)
3938:
3937:
3935:
3934:
3929:
3924:
3919:
3914:
3908:
3906:
3905:(EC 2.7.11.19)
3899:
3898:
3896:
3895:
3890:
3885:
3880:
3874:
3872:
3871:(EC 2.7.11.18)
3865:
3864:
3862:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3580:
3578:
3577:(EC 2.7.11.17)
3571:
3570:
3568:
3567:
3562:
3557:
3551:
3549:
3548:(EC 2.7.11.16)
3542:
3541:
3539:
3538:
3533:
3527:
3525:
3524:(EC 2.7.11.15)
3518:
3517:
3515:
3514:
3508:
3506:
3505:(EC 2.7.11.14)
3499:
3498:
3496:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3429:
3427:
3426:(EC 2.7.11.13)
3420:
3419:
3417:
3416:
3411:
3405:
3403:
3402:(EC 2.7.11.12)
3396:
3395:
3393:
3392:
3387:
3382:
3377:
3372:
3366:
3364:
3363:(EC 2.7.11.11)
3357:
3356:
3354:
3353:
3348:
3343:
3338:
3333:
3328:
3322:
3320:
3319:(EC 2.7.11.10)
3313:
3312:
3310:
3309:
3305:
3303:
3296:
3295:
3293:
3292:
3287:
3281:
3279:
3272:
3271:
3269:
3268:
3267:
3266:
3261:
3256:
3245:
3243:
3236:
3235:
3233:
3232:
3226:
3224:
3217:
3216:
3214:
3213:
3208:
3203:
3198:
3192:
3190:
3183:
3182:
3180:
3179:
3174:
3169:
3163:
3161:
3154:
3153:
3151:
3150:
3149:
3148:
3143:
3138:
3130:
3129:
3128:
3123:
3115:
3114:
3113:
3108:
3096:
3094:
3087:
3086:
3084:
3083:
3078:
3073:
3068:
3062:
3060:
3053:
3052:
3050:
3049:
3048:
3047:
3037:
3036:
3035:
3030:
3025:
3020:
3010:
3005:
3000:
2999:
2998:
2993:
2988:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2922:
2920:
2909:
2908:
2895:
2894:
2878:
2877:
2870:
2863:
2855:
2846:
2845:
2843:
2842:
2836:
2829:
2826:
2823:
2822:
2817:
2816:
2809:
2802:
2794:
2788:
2787:
2782:
2775:
2774:External links
2772:
2770:
2769:
2749:(14): 1514–8.
2734:
2705:
2668:
2639:
2596:
2553:
2509:
2507:
2504:
2501:
2500:
2459:
2418:
2377:
2336:
2287:
2238:
2197:
2156:
2115:
2074:
2033:
1983:
1931:
1877:
1823:
1809:
1795:
1754:
1725:(3–4): 301–3.
1709:
1691:
1673:
1652:
1630:
1629:
1627:
1624:
1580:
1577:
1512:
1509:
1468:
1465:
1445:
1444:
1441:
1440:
1435:
1425:
1424:
1418:
1417:
1414:
1413:
1411:
1409:
1402:
1401:
1394:
1387:
1383:
1382:
1379:
1378:
1368:
1367:
1361:
1358:
1357:
1347:
1346:
1340:
1336:
1335:
1332:
1331:
1321:
1320:
1314:
1311:
1310:
1300:
1299:
1293:
1289:
1288:
1285:
1284:
1276:
1275:
1269:
1266:
1265:
1257:
1256:
1250:
1244:
1243:
1240:
1239:
1231:
1230:
1224:
1221:
1220:
1212:
1211:
1205:
1199:
1198:
1195:
1194:
1186:
1185:
1179:
1176:
1175:
1167:
1166:
1160:
1154:
1153:
1148:
1143:
1139:
1138:
1128:
1127:
1124:
1123:
1112:
1111:
1109:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
902:
900:
896:
895:
893:
892:
887:
882:
877:
875:early endosome
872:
867:
862:
857:
852:
847:
842:
837:
835:focal adhesion
832:
826:
824:
820:
819:
817:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
745:
743:
739:
738:
728:
727:
724:
723:
720:
719:
711:
710:
699:
693:
692:
689:
688:
680:
679:
676:
675:
673:
672:
668:
664:
660:
656:
652:
648:
644:
640:
636:
632:
629:
628:
617:
614:
613:
611:
610:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
567:
566:
554:
553:
545:
534:
528:
527:
524:RNA expression
516:
515:
512:
511:
503:
499:
498:
490:
487:
482:
476:
475:
466:
459:
453:
449:
448:
443:
437:
436:
428:
427:
415:
414:
411:
410:
402:
398:
397:
389:
386:
381:
375:
374:
365:
358:
352:
348:
347:
340:
334:
333:
325:
324:
312:
311:
268:
264:
263:
255:
247:
246:
242:
241:
238:
237:
234:
233:
75:
74:
66:
65:
54:
48:
47:
39:
38:
30:
29:
19:Main article:
15:
9:
6:
4:
3:
2:
5047:
5036:
5033:
5031:
5028:
5027:
5025:
5015:
5010:
5005:
5004:
5001:
4987:
4983:
4982:
4977:
4974:
4970:
4969:
4964:
4961:
4957:
4956:
4951:
4948:
4944:
4943:
4938:
4935:
4931:
4930:
4925:
4922:
4918:
4917:
4912:
4909:
4905:
4904:
4899:
4898:
4896:
4892:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4862:
4860:
4856:
4850:
4847:
4845:
4844:Enzyme family
4842:
4840:
4837:
4835:
4832:
4831:
4829:
4825:
4819:
4816:
4814:
4811:
4809:
4808:Cooperativity
4806:
4804:
4801:
4800:
4798:
4794:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4767:Oxyanion hole
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4749:
4747:
4743:
4739:
4732:
4727:
4725:
4720:
4718:
4713:
4712:
4709:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4655:
4653:
4651:
4647:
4643:
4638:
4633:
4629:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4559:
4558:
4555:
4554:
4552:
4549:
4545:
4538:
4537:
4535:
4532:
4528:
4521:
4520:
4518:
4515:
4511:
4504:
4503:
4501:
4498:
4494:
4488:
4485:
4483:
4480:
4478:
4475:
4474:
4472:
4469:
4465:
4459:
4456:
4454:
4451:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4413:
4412:
4409:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4386:
4385:
4382:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4343:
4340:
4339:
4338:
4335:
4334:
4332:
4329:
4325:
4317:
4314:
4312:
4309:
4307:
4304:
4303:
4302:
4299:
4295:
4292:
4290:
4287:
4285:
4282:
4281:
4280:
4277:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4239:
4238:
4235:
4234:
4232:
4229:
4225:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4175:
4173:
4170:
4166:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4066:
4064:
4061:
4057:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4032:
4030:
4027:
4023:
4019:
4014:
4009:
4005:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3972:
3970:
3967:
3963:
3957:
3954:
3952:
3949:
3948:
3946:
3943:
3939:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3909:
3907:
3904:
3900:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3875:
3873:
3870:
3866:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3581:
3579:
3576:
3572:
3566:
3563:
3561:
3558:
3556:
3553:
3552:
3550:
3547:
3543:
3537:
3534:
3532:
3529:
3528:
3526:
3523:
3519:
3513:
3510:
3509:
3507:
3504:
3500:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3430:
3428:
3425:
3421:
3415:
3412:
3410:
3407:
3406:
3404:
3401:
3397:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3367:
3365:
3362:
3358:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3323:
3321:
3318:
3314:
3307:
3306:
3304:
3302:(EC 2.7.11.9)
3301:
3297:
3291:
3288:
3286:
3283:
3282:
3280:
3278:(EC 2.7.11.8)
3277:
3273:
3265:
3262:
3260:
3257:
3255:
3252:
3251:
3250:
3249:Aurora kinase
3247:
3246:
3244:
3242:(EC 2.7.11.7)
3241:
3237:
3231:
3228:
3227:
3225:
3223:(EC 2.7.11.6)
3222:
3218:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3193:
3191:
3189:(EC 2.7.11.5)
3188:
3184:
3178:
3175:
3173:
3170:
3168:
3165:
3164:
3162:
3160:(EC 2.7.11.4)
3159:
3155:
3147:
3144:
3142:
3139:
3137:
3134:
3133:
3131:
3127:
3124:
3122:
3119:
3118:
3116:
3112:
3109:
3107:
3104:
3103:
3101:
3098:
3097:
3095:
3093:(EC 2.7.11.3)
3092:
3088:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3063:
3061:
3059:(EC 2.7.11.2)
3058:
3054:
3046:
3043:
3042:
3041:
3038:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3015:
3014:
3013:EIF-2 kinases
3011:
3009:
3006:
3004:
3001:
2997:
2994:
2992:
2989:
2987:
2984:
2983:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2923:
2921:
2919:(EC 2.7.11.1)
2918:
2914:
2910:
2905:
2900:
2896:
2891:
2887:
2883:
2876:
2871:
2869:
2864:
2862:
2857:
2856:
2853:
2839:
2833:
2828:
2827:
2824:
2815:
2810:
2808:
2803:
2801:
2796:
2795:
2792:
2786:
2783:
2781:
2778:
2777:
2766:
2762:
2757:
2752:
2748:
2744:
2740:
2735:
2731:
2727:
2723:
2719:
2715:
2711:
2710:Curr. HIV Res
2706:
2702:
2698:
2694:
2690:
2686:
2682:
2678:
2674:
2669:
2665:
2661:
2657:
2653:
2649:
2645:
2644:Curr. HIV Res
2640:
2636:
2632:
2628:
2624:
2619:
2614:
2611:(9): 726–35.
2610:
2606:
2602:
2597:
2593:
2589:
2584:
2579:
2575:
2571:
2567:
2563:
2562:Mol Cell Biol
2559:
2554:
2550:
2546:
2541:
2536:
2532:
2528:
2524:
2520:
2516:
2511:
2510:
2496:
2492:
2487:
2482:
2478:
2474:
2473:J. Biol. Chem
2470:
2463:
2455:
2451:
2446:
2441:
2437:
2433:
2432:J. Biol. Chem
2429:
2422:
2414:
2410:
2405:
2400:
2396:
2392:
2391:J. Biol. Chem
2388:
2381:
2373:
2369:
2364:
2359:
2355:
2351:
2350:J. Biol. Chem
2347:
2340:
2332:
2328:
2323:
2318:
2314:
2310:
2306:
2302:
2298:
2291:
2283:
2279:
2274:
2269:
2265:
2261:
2257:
2253:
2249:
2242:
2234:
2230:
2225:
2220:
2216:
2212:
2211:J. Biol. Chem
2208:
2201:
2193:
2189:
2184:
2179:
2175:
2171:
2170:J. Biol. Chem
2167:
2160:
2152:
2148:
2143:
2138:
2134:
2130:
2129:J. Biol. Chem
2126:
2119:
2111:
2107:
2102:
2097:
2093:
2089:
2088:J. Biol. Chem
2085:
2078:
2070:
2066:
2061:
2056:
2052:
2048:
2047:J. Biol. Chem
2044:
2037:
2029:
2025:
2021:
2017:
2013:
2009:
2005:
2001:
2000:
1992:
1990:
1988:
1979:
1975:
1970:
1965:
1961:
1957:
1953:
1949:
1945:
1938:
1936:
1927:
1923:
1918:
1913:
1909:
1905:
1901:
1897:
1893:
1886:
1884:
1882:
1873:
1869:
1864:
1859:
1854:
1849:
1845:
1841:
1837:
1830:
1828:
1819:
1813:
1805:
1799:
1791:
1787:
1782:
1777:
1773:
1769:
1765:
1758:
1750:
1746:
1741:
1740:11577/2469645
1736:
1732:
1728:
1724:
1720:
1713:
1705:
1701:
1695:
1687:
1683:
1677:
1670:
1666:
1661:
1659:
1657:
1649:
1645:
1640:
1638:
1636:
1631:
1623:
1621:
1617:
1614:
1610:
1606:
1602:
1598:
1594:
1590:
1586:
1576:
1574:
1569:
1565:
1564:recombination
1562:
1558:
1553:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1522:
1518:
1508:
1506:
1502:
1498:
1497:proliferation
1494:
1490:
1486:
1482:
1478:
1474:
1464:
1462:
1459:
1455:
1451:
1439:
1434:
1430:
1426:
1423:
1419:
1412:
1410:
1407:
1403:
1399:
1395:
1392:
1388:
1384:
1377:
1375:
1369:
1365:
1362:
1356:
1354:
1348:
1344:
1341:
1337:
1330:
1328:
1322:
1318:
1315:
1309:
1307:
1301:
1297:
1294:
1292:RefSeq (mRNA)
1290:
1283:
1282:
1277:
1273:
1270:
1264:
1263:
1258:
1254:
1251:
1249:
1245:
1238:
1237:
1232:
1228:
1225:
1219:
1218:
1213:
1209:
1206:
1204:
1200:
1193:
1192:
1187:
1183:
1180:
1174:
1173:
1168:
1164:
1161:
1159:
1155:
1152:
1149:
1147:
1144:
1140:
1137:
1133:
1129:
1122:
1118:
1113:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
946:cell motility
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
903:
901:
898:
897:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
865:late endosome
863:
861:
858:
856:
853:
851:
848:
846:
845:mitochondrion
843:
841:
838:
836:
833:
831:
828:
827:
825:
822:
821:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
746:
744:
741:
740:
737:
736:Gene ontology
733:
729:
717:
712:
708:
703:
700:
698:
694:
686:
681:
670:
666:
663:temporal lobe
662:
658:
654:
650:
646:
642:
638:
634:
633:
630:
626:
621:
618:
608:
604:
600:
596:
592:
588:
584:
580:
576:
572:
571:
568:
564:
559:
556:
555:
552:
550:
546:
544:
543:
539:
538:
535:
533:
529:
525:
521:
517:
509:
504:
500:
496:
491:
481:
477:
470:
463:
457:
450:
442:
438:
434:
429:
425:
420:
416:
408:
403:
399:
395:
390:
380:
376:
369:
362:
356:
349:
345:
339:
335:
331:
326:
322:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
265:
260:
253:
248:
243:
232:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
26:
22:
4981:Translocases
4978:
4965:
4952:
4939:
4926:
4916:Transferases
4913:
4900:
4757:Binding site
4657:
4188:P70S6 kinase
2837:
2746:
2742:
2716:(1): 57–64.
2713:
2709:
2676:
2673:Immunol. Rev
2672:
2650:(1): 87–94.
2647:
2643:
2608:
2604:
2565:
2561:
2525:(3): 701–5.
2522:
2518:
2476:
2472:
2462:
2435:
2431:
2421:
2394:
2390:
2380:
2353:
2349:
2339:
2304:
2300:
2290:
2255:
2251:
2241:
2214:
2210:
2200:
2173:
2169:
2159:
2132:
2128:
2118:
2091:
2087:
2077:
2050:
2046:
2036:
2003:
1997:
1951:
1948:J. Cell Biol
1947:
1899:
1895:
1843:
1839:
1812:
1798:
1771:
1767:
1757:
1722:
1718:
1712:
1703:
1694:
1685:
1676:
1582:
1579:Interactions
1554:
1514:
1470:
1457:
1449:
1448:
1371:
1350:
1324:
1303:
1279:
1260:
1234:
1215:
1189:
1170:
1150:
1145:
1031:MAPK cascade
850:cytoskeleton
547:
540:
267:External IDs
78:
4752:Active site
4639:(EC 2.7.12)
4026:Polo kinase
3966:Polo kinase
2820:PDB gallery
1768:J Biol Chem
1525:polymorphic
1489:MAP kinases
764:ATP binding
506:64,160,913
493:64,093,052
405:66,491,656
392:66,386,837
245:Identifiers
5024:Categories
4955:Isomerases
4929:Hydrolases
4796:Regulation
3317:IκB kinase
2892:2.7.11-12)
2743:Cell Cycle
2519:Biochem. J
1671:, May 2017
1650:, May 2017
1626:References
1535:. During
1529:insertions
981:chemotaxis
551:(ortholog)
288:HomoloGene
5035:EC 2.7.12
4834:EC number
3443:PKC alpha
2679:: 30–49.
1840:PLOS Biol
1597:MAP2K1IP1
1533:deletions
1374:NP_032953
1353:NP_002746
1327:NM_008927
1306:NM_002755
1136:Orthologs
880:cytoplasm
296:GeneCards
4858:Kinetics
4782:Cofactor
4745:Activity
3799:KIAA0999
3694:MAPKAPK5
3689:MAPKAPK3
3684:MAPKAPK2
2765:16861903
2730:16454711
2701:13811917
2693:16313339
2664:15638726
2635:23298305
2495:10969079
2454:11279118
2413:11352917
2372:11823456
2331:12697810
2282:10523642
2233:11044439
1978:11266467
1926:10757792
1872:20976044
1667:–
1646:–
1609:MAPK8IP3
1585:interact
1467:Function
1422:Wikidata
1115:Sources:
830:membrane
667:amygdala
384:15q22.31
5014:Biology
4968:Ligases
4738:Enzymes
4458:MAP3K14
4436:MAP3K11
4431:MAP3K10
4421:MAP3K13
4416:MAP3K12
4218:RPS6KC1
4213:RPS6KA1
4208:RPS6KA3
4203:RPS6KA2
4198:RPS6KB2
4183:RPS6KA4
4178:RPS6KA5
3829:Kalirin
3794:SNF1LK2
3033:EIF2AK4
3028:EIF2AK3
2882:Kinases
2627:7601337
2605:FASEB J
2592:8114697
2549:1379797
2540:1132850
2192:8226933
2151:8626767
2110:9006895
2069:9553107
2028:9733512
2008:Bibcode
1999:Science
1969:2195784
1863:2957403
1790:8388392
1749:9465908
1669:Ensembl
1648:Ensembl
1573:mitosis
1549:homolog
1537:meiosis
1521:diploid
1517:genomes
1511:Meiosis
1248:UniProt
1203:Ensembl
1142:Species
1121:QuickGO
885:cytosol
855:nucleus
526:pattern
284:1346866
252:Aliases
5000:Portal
4942:Lyases
4688:MAP2K7
4683:MAP2K6
4678:MAP2K5
4673:MAP2K4
4668:MAP2K3
4663:MAP2K2
4658:MAP2K1
4609:ACVRL1
4604:ACVR2B
4599:ACVR2A
4594:ACVR1C
4589:ACVR1B
4572:BMPR1B
4567:BMPR1A
4441:MAP3K7
4426:MAP3K9
4377:MAP3K8
4372:MAP3K7
4367:MAP3K6
4362:MAP3K5
4357:MAP3K4
4352:MAP3K3
4347:MAP3K2
4342:MAP3K1
4316:MAPK14
4311:MAPK13
4306:MAPK11
4294:MAPK10
4272:MAPK15
4267:MAPK12
4159:CDC2L1
4134:CDC2L5
3809:SNF1LK
3634:CAMK2G
3629:CAMK2D
3624:CAMK2B
3619:CAMK2A
3609:CAMK1G
3604:CAMK1D
3599:CAMK1B
3594:CAMK1A
3448:PRKCB1
3385:PRKACA
3380:PRKACB
3375:PRKACG
3351:IKBKAP
3177:BCKDHB
3172:BCKDHA
3146:PRKAG3
3141:PRKAG2
3136:PRKAG1
3126:PRKAB2
3121:PRKAB1
3111:PRKAA2
3106:PRKAA1
2951:STK38L
2763:
2728:
2699:
2691:
2662:
2633:
2625:
2590:
2583:358518
2580:
2547:
2537:
2493:
2452:
2411:
2370:
2329:
2322:153192
2319:
2280:
2270:
2231:
2190:
2149:
2108:
2067:
2026:
1976:
1966:
1924:
1914:
1870:
1860:
1788:
1747:
1620:MAP3K1
1618:, and
1485:kinase
1458:MAP2K1
1454:enzyme
1452:is an
1408:search
1406:PubMed
1281:P31938
1262:Q02750
1158:Entrez
697:BioGPS
651:zygote
300:MAP2K1
276:176872
259:MAP2K1
28:MAP2K1
4894:Types
4650:MAP2K
4584:ACVR1
4577:BMPR2
4562:BMPR1
4487:GSK-3
4328:MAP3K
4289:MAPK9
4284:MAPK8
4262:MAPK7
4257:MAPK6
4252:MAPK4
4247:MAPK3
4242:MAPK1
4154:PFTK1
4149:PCTK3
4144:PCTK2
4139:PCTK1
4129:CDK12
4124:CDK10
4099:CDKL5
4079:CDKL2
3956:STK19
3951:EEF2K
3932:PHKG2
3927:PHKG1
3917:PHKA2
3912:PHKA1
3893:MYLK4
3888:MYLK3
3883:MYLK2
3859:DCLK1
3854:Titin
3844:TRIB3
3839:TRIB2
3834:TRIB1
3824:TSSK2
3804:STK40
3789:PSKH1
3784:PRKD3
3779:PRKD2
3759:PHKG2
3754:PHKG1
3744:OBSCN
3739:NUAK2
3734:NUAK1
3729:MKNK2
3724:MKNK1
3714:MARK4
3709:MARK3
3704:MARK2
3699:MARK1
3679:STK11
3674:DAPK3
3669:DAPK2
3664:DAPK1
3659:CHEK2
3654:CHEK1
3639:CAMK4
3614:CAMK2
3589:CAMK1
3584:BRSK2
3478:PRKCQ
3473:PRKCI
3468:PRKCG
3463:PRKCH
3458:PRKCE
3453:PRKCD
3414:PRKG1
3346:IKBKG
3341:IKBKE
3290:STK10
3285:FASTK
3211:IDH3G
3206:IDH3B
3201:IDH3A
3167:BCKDK
2961:ROCK1
2946:STK38
2941:MAST2
2936:MAST1
2931:LATS2
2926:LATS1
2697:S2CID
2631:S2CID
2273:84763
1917:85596
1613:MAPK1
1605:MAPK3
1601:GRB10
1589:C-Raf
1587:with
1191:26395
1151:Mouse
1146:Human
1117:Amigo
549:Mouse
542:Human
489:Start
424:Mouse
388:Start
321:Human
4986:list
4979:EC7
4973:list
4966:EC6
4960:list
4953:EC5
4947:list
4940:EC4
4934:list
4927:EC3
4921:list
4914:EC2
4908:list
4901:EC1
4477:TPK1
4453:CDC7
4411:MLKs
4404:KSR2
4399:KSR1
4394:BRAF
4389:ARAF
4384:RAFs
4119:CDK9
4114:CDK8
4109:CDK7
4104:CDK6
4094:CDK5
4089:CDK4
4084:CDK3
4074:CDK2
4069:CDK1
4050:PLK4
4045:PLK3
4040:PLK2
4035:PLK1
3990:PLK4
3985:PLK3
3980:PLK2
3975:PLK1
3922:PHKB
3878:MYLK
3849:TRIO
3819:SPEG
3814:SNRK
3774:PKD1
3769:PIM2
3764:PIM1
3749:PASK
3719:MELK
3649:CASK
3644:MLCK
3565:GRK6
3560:GRK5
3555:GRK4
3493:PKN3
3488:PKN2
3390:PRKY
3336:TBK1
3331:IKK2
3326:CHUK
3230:STK4
3196:IDH2
3081:PDK4
3076:PDK3
3071:PDK2
3066:PDK1
3045:WEE1
3040:Wee1
3008:mTOR
2996:AKT3
2991:AKT2
2986:AKT1
2976:SGK3
2971:SGK2
2838:1s9j
2761:PMID
2726:PMID
2689:PMID
2660:PMID
2623:PMID
2588:PMID
2545:PMID
2491:PMID
2450:PMID
2409:PMID
2368:PMID
2327:PMID
2278:PMID
2229:PMID
2188:PMID
2147:PMID
2106:PMID
2065:PMID
2024:PMID
1974:PMID
1922:PMID
1868:PMID
1786:PMID
1745:PMID
1531:and
1527:for
1515:The
1461:gene
1172:5604
532:Bgee
480:Band
441:Chr.
379:Band
338:Chr.
292:2063
272:OMIM
229:5BX0
225:4U81
221:4U80
217:4U7Z
213:4MNE
209:4LMN
205:4ARK
201:4ANB
197:4AN9
193:4AN3
189:4AN2
185:3ZM4
181:3ZLY
177:3ZLX
173:3ZLW
169:3ZLS
165:3WIG
161:3W8Q
157:3VVH
153:3V04
149:3V01
145:3SLS
141:3PP1
137:3OS3
133:3ORN
129:3MBL
125:3EQI
121:3EQH
117:3EQG
113:3EQF
109:3EQD
105:3EQC
101:3EQB
97:3E8N
93:3DY7
89:3DV3
85:2P55
81:1S9J
62:RCSB
59:PDBe
4482:TTK
4446:ZAK
3023:HRI
3018:PKR
2966:SGK
2956:CIT
2751:doi
2718:doi
2681:doi
2677:208
2652:doi
2613:doi
2578:PMC
2570:doi
2535:PMC
2527:doi
2523:285
2481:doi
2477:275
2440:doi
2436:276
2399:doi
2395:276
2358:doi
2354:277
2317:PMC
2309:doi
2268:PMC
2260:doi
2219:doi
2215:275
2178:doi
2174:268
2137:doi
2133:271
2096:doi
2092:272
2055:doi
2051:273
2016:doi
2004:281
1964:PMC
1956:doi
1952:152
1912:PMC
1904:doi
1858:PMC
1848:doi
1776:doi
1772:268
1735:hdl
1727:doi
1616:MP1
1519:of
502:End
401:End
304:OMA
280:MGI
52:PDB
5026::
3132:γ
3117:β
3102:α
2890:EC
2884::
2759:.
2745:.
2741:.
2724:.
2712:.
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2675:.
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508:bp
495:bp
407:bp
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302:;
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286:;
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278:;
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227:,
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