1314:
249:
226:
148:
123:
514:
507:
500:
255:
154:
4566:
31:
1290:
1480:. Additionally, LOX expression is an indicator of 5-year survival in patients, with a 71% chance of survival for patients with low LOX levels, compared to 43% for patients with high LOX levels. Thus, upregulation of lysyl oxidase is a predictor of poor prognosis in early-stage adenocarcinoma patients.
1309:
substituent. Furthermore, it is neutral charge at physiological pH. The ε-amine is condenses with LTQ to give the Schiff base via reaction with LTQ. The rate-limiting removal of a ε-proton yields an imine. Subsequent hydrolysis of the imine leads to release of the allysine residue. Molecular oxygen
1280:
q23.3-31.2. The DNA sequence encodes a polypeptide of 417 amino acids, the first 21 residues of which constitute a signal peptide, with a weight of approximately 32 kDa. The carboxyterminus contains the active copper (II) ion, lysine, tyrosine, and cysteine residues that comprise the catalytically
1388:, two X-linked recessive disorders characterized by a mutation in a gene coding for a protein involved in copper transport. Thus, not only is LOX crucial to cardiovascular development, it plays a major role in connective tissue development and may also be important in neurological function.
3038:
Yasutake A, Powers JC (Jun 1981). "Reactivity of human leukocyte elastase and porcine pancreatic elastase toward peptide 4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is selective for cross-linked regions of elastin".
2253:
Huang HY, Chen SZ, Zhang WT, Wang SS, Liu Y, Li X, Sun X, Li YM, Wen B, Lei QY, Tang QQ (May 2013). "Induction of epithelial-mesenchymal transition (EMT)-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment".
2754:
Mariani TJ, Trackman PC, Kagan HM, Eddy RL, Shows TB, Boyd CD, Deak SB (Jun 1992). "The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene)".
1511:). High levels of LOX were associated with high blood vessel density in patient samples. Clinically relevant LOX inhibitors may help slow cancer progression by downregulating crucial growth factors that promote solid tumor progression.
3175:
Csiszar K, Mariani TJ, Gosin JS, Deak SB, Boyd CD (May 1993). "A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene".
262:
161:
1476:, lysyl oxidase is found in high concentrations. LOX immunostaining has revealed that high LOX expression is associated with high extent of carcinoma invasion in samples obtained from surgically removed lung
1449:
LOX expression was also detected in megakaryocytes, or bone marrow cells responsible for the production of platelets. Data derived from a mouse model of myelofibrosis implicated LOX in bone marrow fibrosis.
1445:
In fact, recent research has shown overexpression of LOX as crucial to promoting tumor growth and metastasis in several cancers, including breast cancer, non-small cell lung cancer, and colorectal cancer.
2087:
Siegel RC, Fu JC, Uto N, Horiuchi K, Fujimoto D (Oct 1982). "Collagen cross-linking: lysyl oxidase dependent synthesis of pyridinoline in vitro: confirmation that pyridinoline is derived from collagen".
1364:
The importance of lysyl oxidase-derived cross-linking was established from animal studies in which lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with
2821:
Hämäläinen ER, Jones TA, Sheer D, Taskinen K, Pihlajaniemi T, Kivirikko KI (Nov 1991). "Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2".
1669:
Hämäläinen ER, Jones TA, Sheer D, Taskinen K, Pihlajaniemi T, Kivirikko KI (Nov 1991). "Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2".
1514:
Hence, inhibitors of the LOX enzyme may be useful in preventing angiogenesis, tumor progression, and metastasis as well as treating other fibrotic disease involving remodeling of the
2879:
Kuivaniemi H, Ala-Kokko L, Kivirikko KI (Sep 1986). "Secretion of lysyl oxidase by cultured human skin fibroblasts and effects of monensin, nigericin, tunicamycin and colchicine".
2289:
El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, Toner M, Bhatia SN, Irimia D, Vincent-Salomon A, Karnoub AE (Oct 2012).
2850:
Konishi A, Iguchi H, Ochi J, Kinoshita R, Miura K, Uchino H (Oct 1985). "Increased lysyl oxidase activity in culture medium of nonparenchymal cells from fibrotic livers".
2784:
Murawaki Y, Kusakabe Y, Hirayama C (Dec 1991). "Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin".
2516:
Wilgus ML, Borczuk AC, Stoopler M, Ginsburg M, Gorenstein L, Sonett JR, Powell CA (May 2011). "Lysyl oxidase: a lung adenocarcinoma biomarker of invasion and survival".
1747:
Duff AP, Cohen AE, Ellis PJ, Kuchar JA, Langley DB, Shepard EM, Dooley DM, Freeman HC, Guss JM (Dec 2003). "The crystal structure of Pichia pastoris lysyl oxidase".
1305:-containing copper amine oxidases. The reaction requires the cofactor lysyl tyrosylquinone (LTQ). The LTQ cofactor is unique among quinones because it contains an
1469:, which cleaves collagen, enhancing the invasion of metastasizing tumor cells. In contrast, LOX inhibition prevents CD11b+ cell recruitment and metastatic growth.
2206:"Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues"
1785:
Gacheru SN, Trackman PC, Shah MA, O'Gara CY, Spacciapoli P, Greenaway FT, Kagan HM (Nov 1990). "Structural and catalytic properties of copper in lysyl oxidase".
2348:
Shi W, Yang B, Li X, Sun S, Wang L, Jiao S (Dec 2012). "The effect of lysyl oxidase polymorphism on susceptibility and prognosis of nonsmall cell lung cancer".
2123:
Dawson DA, Rinaldi AC, Pöch G (Aug 2002). "Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism".
1453:
In a rodent model of breast cancer, a small-molecule or antibody inhibitors of LOX abolished metastasis. LOX secreted by hypoxic breast tumor cells crosslinks
3205:
Vetter U, Weis MA, Mörike M, Eanes ED, Eyre DR (Feb 1993). "Collagen crosslinks and mineral crystallinity in bone of patients with osteogenesis imperfecta".
2937:
Järveläinen H, Halme T, Rönnemaa T (1982). "Effect of cortisol on the proliferation and protein synthesis of human aortic smooth muscle cells in culture".
1317:
Mechanism of the oxidation of the side chain of lysine residues by the action of LTQ. The lysyl oxidase participates in the regeneration of the quinone.
877:
858:
84:
2908:
Reiser KM, Hennessy SM, Last JA (Dec 1987). "Analysis of age-associated changes in collagen crosslinking in the skin and lung in monkeys and rats".
4087:
1631:
1613:
4215:
4116:
3244:"Metalloproteinase activity secreted by fibrogenic cells in the processing of prolysyl oxidase. Potential role of procollagen C-proteinase"
3001:
Lien YH, Stern R, Fu JC, Siegel RC (Sep 1984). "Inhibition of collagen fibril formation in vitro and subsequent cross-linking by glucose".
4124:
3993:
3396:
1350:
collagen and elastin, which is essential for stabilization of collagen fibrils and for the integrity and elasticity of mature elastin.
1109:
4160:
1116:
4238:
3316:"2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth"
1652:
3134:"Tyrosine-rich acidic matrix protein (TRAMP) is a tyrosine-sulphated and widely distributed protein of the extracellular matrix"
1986:
Akagawa M, Suyama K (Feb 2001). "Characterization of a model compound for the lysine tyrosylquinone cofactor of lysyl oxidase".
2968:"Human placental lysyl oxidase. Purification, partial characterization, and preparation of two specific antisera to the enzyme"
1373:, characterized by poor bone formation and strength, hyperextensible skin, weak ligaments, and increased occurrence of aortic
3277:
Khakoo A, Thomas R, Trompeter R, Duffy P, Price R, Pope FM (Feb 1997). "Congenital cutis laxa and lysyl oxidase deficiency".
2030:
1266:
1596:
4586:
4080:
2682:
Kagan HM, Li W (Mar 2003). "Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell".
1861:
Kagan HM, Li W (Mar 2003). "Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell".
4065:
4044:
1575:
1500:
2469:"Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche"
248:
4285:
4182:
4120:
2664:
2608:
RodrĂguez C, RodrĂguez-Sinovas A, MartĂnez-González J (May 2008). "Lysyl oxidase as a potential therapeutic target".
2063:
3103:
Hämäläinen ER, Kemppainen R, Pihlajaniemi T, Kivirikko KI (Sep 1993). "Structure of the human lysyl oxidase gene".
225:
4073:
1600:
1579:
1419:
1403:), the activity of LOX was reduced by up to 80%, and the phenotype of the lungs resembles those of patients with
4054:
3389:
2158:
Wilmarth KR, Froines JR (Nov 1992). "In vitro and in vivo inhibition of lysyl oxidase by aminopropionitriles".
1395:
and the skin, as collagen and elastin represent 50-60% of the composition of the lung, and 75% of the skin. In
922:
4441:
3776:
3680:
3655:
903:
3808:
3737:
3675:
3670:
1822:"The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers"
147:
122:
64:
1310:
and the copper ion are utilized to reoxidize the cofactor, producing hydrogen peroxide as a side product.
3726:
3685:
3572:
3567:
3562:
3556:
3475:
4556:
4247:
4150:
4108:
3764:
3700:
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3615:
3605:
3535:
3468:
2559:
Baker AM, Bird D, Welti JC, Gourlaouen M, Lang G, Murray GI, Reynolds AR, Cox TR, Erler JT (Jan 2013).
1947:"Oxidation, cross-linking, and insolubilization of recombinant tropoelastin by purified lysyl oxidase"
1906:"Characterization of the Native Lysine Tyrosylquinone Cofactor in Lysyl Oxidase by Raman Spectroscopy"
1442:
breast and head and neck tumors. Patients with high LOX-expressing tumors have poor overall survival.
261:
160:
4542:
4529:
4516:
4503:
4490:
4477:
4464:
4426:
4138:
3753:
3488:
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3382:
1435:
3314:
Smithen DA, Leung LM, Challinor M, Lawrence R, Tang H, Niculescu-Duvaz D, et al. (March 2020).
254:
153:
51:
4436:
4390:
4333:
4104:
3368:
1704:
Requena JR, Levine RL, Stadtman ER (2003). "Recent
Advances in the Analysis of Oxidized Proteins".
1088:
1084:
1059:
1055:
1029:
1025:
1000:
996:
72:
2391:
Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT (Mar 2011).
4596:
4591:
4338:
4228:
4133:
2561:"Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis"
1820:
Thomassin L, Werneck CC, Broekelmann TJ, Gleyzal C, Hornstra IK, Mecham RP, Sommer P (Dec 2005).
1552:
1385:
1270:
1366:
1092:
1063:
1021:
992:
1313:
1281:
active site. The three-dimensional structure of human lysyl oxidase has not yet been resolved.
2393:"The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer"
4359:
4278:
4196:
3822:
3070:"A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase"
1377:. These abnormalities correlated well with decreased cross-linking of collagen and elastin.
4431:
4173:
3417:
3010:
2302:
2167:
1515:
1216:
136:
4095:
2291:"Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy"
1465:
myeloid cell recruitment. CD11b+ cells in turn adhere to crosslinked collagen and produce
8:
4395:
4252:
3649:
3364:
2432:
Erler JT, Giaccia AJ (Nov 2006). "Lysyl oxidase mediates hypoxic control of metastasis".
92:
3014:
2651:. Progress in Nucleic Acid Research and Molecular Biology. Vol. 70. pp. 1–32.
2306:
2171:
2050:. Progress in Nucleic Acid Research and Molecular Biology. Vol. 70. pp. 1–32.
1503:(VEGF) expression and secretion, which then promotes angiogenesis by phosphorylation of
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3988:
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3163:
2950:
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2707:
2585:
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2541:
2493:
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Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ (Jan 2009).
2373:
2325:
2290:
2230:
2205:
2204:
Mäki JM, Sormunen R, Lippo S, Kaarteenaho-Wiik R, Soininen R, Myllyharju J (Oct 2005).
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96:
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2003:
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1682:
1458:
1439:
44:
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3242:
Panchenko MV, Stetler-Stevenson WG, Trubetskoy OV, Gacheru SN, Kagan HM (Mar 1996).
3234:
3167:
2813:
2711:
2545:
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1733:
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4369:
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4271:
3918:
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3112:
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3018:
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2917:
2888:
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2525:
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1995:
1958:
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4318:
4191:
4039:
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3891:
3886:
3482:
3444:
3331:
1249:
556:
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
316:
100:
2719:
Svinarich DM, Twomey TA, Macauley SP, Krebs CJ, Yang TP, Krawetz SA (Jul 1992).
1636:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1618:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1346:
precursors. These aldehydes react with unmodified lysine residues, resulting in
4570:
4459:
4400:
4100:
3526:
2295:
Proceedings of the
National Academy of Sciences of the United States of America
1547:
1477:
1381:
1220:
417:
2484:
2361:
2267:
2179:
1717:
4580:
4364:
4323:
4178:
3791:
3409:
1922:
1905:
1261:
consists of an active site that includes a Cu(II) atom, coordinated by three
542:
3260:
3243:
3218:
3086:
3069:
3022:
2315:
793:
regulation of platelet-derived growth factor receptor-beta signaling pathway
513:
506:
499:
477:
355:
4313:
3951:
3349:
3241:
3189:
3116:
2797:
2703:
2674:
2629:
2607:
2594:
2537:
2502:
2453:
2418:
2369:
2334:
2275:
2239:
2144:
2073:
2007:
1999:
1882:
1847:
1838:
1821:
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1725:
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1484:
1354:
1277:
1224:
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334:
113:
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3298:
3269:
3226:
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3124:
3095:
3060:
3030:
2993:
2958:
2929:
2900:
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2842:
2805:
2776:
2746:
2409:
2392:
2187:
2109:
1972:
1931:
1806:
1690:
1293:
Lysyl oxidase-catalyzed oxidation of a lysine residue to allysine residue.
1156:
1151:
4537:
4472:
4308:
4029:
3958:
3694:
3639:
3102:
1473:
1472:
In cells lacking TGF-β receptors, a deficiency that is characteristic of
1423:
1254:
967:
948:
3052:
1945:
Bedell-Hogan D, Trackman P, Abrams W, Rosenbloom J, Kagan H (May 1993).
1380:
Developmentally, reduced lysyl oxidase activity have been implicated in
708:
regulation of transforming growth factor beta receptor signaling pathway
3660:
2529:
1347:
1232:
1212:
233:
130:
80:
2695:
1874:
1760:
4511:
4485:
4219:
1904:
Wang SX, Nakamura N, Mure M, Klinman JP, Sanders-Loehr J (Nov 1997).
1415:
1411:
1404:
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1358:
1262:
822:
300:
287:
199:
186:
88:
1944:
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1454:
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1208:
1204:
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1819:
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3841:
3817:
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3769:
3587:
3582:
3577:
3505:
3405:
2203:
1343:
1327:
1302:
1258:
934:
889:
807:
803:
1391:
Lysyl oxidase has also proven crucial to the development of the
68:
30:
4524:
4294:
4164:
3978:
3742:
3715:
3710:
3705:
3630:
3625:
3620:
3610:
3545:
3540:
3498:
3493:
3455:
1508:
1335:
1331:
1298:
1236:
1200:
1187:
1124:
844:
522:
1289:
723:
platelet-derived growth factor receptor-beta signaling pathway
4498:
4143:
4003:
3998:
3968:
3963:
3941:
3923:
3901:
3510:
3313:
2965:
2515:
1784:
1542:
1537:
1532:
1527:
1507:, or Akt, through platelet-derived growth factor receptor β (
1410:
Lysyl oxidase plays a crucial role in the commitment step of
1361:
derived from four lysine residues) that differ in structure.
1228:
3131:
2878:
2820:
2718:
2649:
Lysyl oxidases: a novel multifunctional amine oxidase family
2048:
Lysyl oxidases: a novel multifunctional amine oxidase family
1668:
3983:
3132:
Forbes EG, Cronshaw AD, MacBeath JR, Hulmes DJ (Sep 1994).
1518:, including neurodegenerative and cardiovascular diseases.
1466:
1438:(HIFs), and, hence, LOX expression is often upregulated in
1418:
during development. Its absence may lead to defects in the
1196:
4263:
3276:
2849:
1235:
of the existing tumor, causing it to become malignant and
2288:
2936:
2783:
2753:
2721:"Characterization of the human lysyl oxidase gene locus"
2558:
1369:(BAPN), an inhibitor of lysyl oxidase. This resulted in
324:
3174:
1903:
1499:. Subcutaneous tumor-derived LOX was shown to increase
1297:
Lysyl oxidase the terminal carbon of the side chain of
2966:
Kuivaniemi H, Savolainen ER, Kivirikko KI (Jun 1984).
2910:
Biochimica et
Biophysica Acta (BBA) - General Subjects
2881:
Biochimica et
Biophysica Acta (BBA) - General Subjects
4554:
3204:
2466:
1703:
489:
1746:
1357:
derived from three lysine residues) and in elastin (
2090:
2086:
1988:
2907:
2252:
1592:
1590:
1588:
1571:
1569:
1567:
55:, entrez:4015, lysyl oxidase, AAT10, Lysyl oxidase
3000:
2122:
2014:
1483:Lysyl oxidase has been newly implicated in tumor
271:
170:
4578:
2390:
1219:proteins. Inhibition of lysyl oxidase can cause
703:regulation of striated muscle tissue development
2199:
2197:
2157:
1585:
1564:
1301:side chain. The enzyme belongsthe category of
3067:
3037:
2160:Journal of Toxicology and Environmental Health
2020:
1597:GRCm38: Ensembl release 89: ENSMUSG00000024529
4279:
4081:
3390:
1985:
1780:
1778:
1664:
1662:
2601:
2552:
2509:
2460:
2431:
2425:
2384:
2347:
2341:
2282:
2246:
2194:
2116:
2039:
1979:
1854:
1813:
1353:Complex cross-links are formed in collagen (
3404:
2151:
2080:
2025:. New York: Garland Science. p. 1099.
1938:
1897:
1740:
1576:GRCh38: Ensembl release 89: ENSG00000113083
1334:that catalyzes formation of aldehydes from
748:regulation of megakaryocyte differentiation
4286:
4272:
4088:
4074:
3397:
3383:
1775:
1659:
1414:, or fat cell, formation from pluripotent
3367:at the U.S. National Library of Medicine
3339:
3259:
3149:
3085:
2983:
2736:
2584:
2492:
2408:
2324:
2314:
2229:
1962:
1921:
1837:
2397:Journal of the National Cancer Institute
1647:
1645:
1429:
1312:
1288:
3427:
2681:
2646:
2045:
1860:
1697:
1422:superfamily of proteins, which control
18:Mammalian protein found in Homo sapiens
4579:
3068:Kim Y, Boyd CD, Csiszar K (Mar 1995).
2939:Acta Medica Scandinavica. Supplementum
1321:
1276:In humans, the LOX gene is located on
768:cellular response to organic substance
4267:
4069:
3378:
1642:
1330:is an extracellular copper-dependent
1267:2,4,5-trihydroxyphenylalanine quinone
693:regulation of protein phosphorylation
276:
237:
232:
175:
134:
129:
3207:Journal of Bone and Mineral Research
4045:Cartilage oligomeric matrix protein
3248:The Journal of Biological Chemistry
3074:The Journal of Biological Chemistry
2972:The Journal of Biological Chemistry
2725:The Journal of Biological Chemistry
1951:The Journal of Biological Chemistry
1910:The Journal of Biological Chemistry
1826:The Journal of Biological Chemistry
1787:The Journal of Biological Chemistry
1190:that, in humans, is encoded by the
13:
3291:10.1111/j.1399-0004.1997.tb02430.x
2951:10.1111/j.0954-6820.1982.tb00367.x
2639:
1501:vascular endothelial growth factor
14:
4608:
3358:
2210:The American Journal of Pathology
1199:. It catalyzes the conversion of
713:extracellular matrix organization
581:protein-lysine 6-oxidase activity
4564:
2684:Journal of Cellular Biochemistry
1863:Journal of Cellular Biochemistry
1653:"Entrez Gene: LOX lysyl oxidase"
753:muscle cell cellular homeostasis
512:
505:
498:
260:
253:
247:
224:
159:
152:
146:
121:
29:
1434:LOX expression is regulated by
1420:transforming growth factor beta
738:regulation of apoptotic process
3320:Journal of Medicinal Chemistry
1624:
1606:
1253:, lysyl oxidase constitutes a
1223:, but, at the same time, its
788:cellular response to chemokine
783:regulation of bone development
778:regulation of receptor binding
523:More reference expression data
478:More reference expression data
1:
2985:10.1016/S0021-9258(17)39828-9
2769:10.1016/S0934-8832(11)80067-3
2738:10.1016/S0021-9258(19)49723-8
2657:10.1016/S0079-6603(01)70012-8
2622:10.1358/dnp.2008.21.4.1213351
2577:10.1158/0008-5472.CAN-12-2447
2446:10.1158/0008-5472.CAN-06-3197
2222:10.1016/S0002-9440(10)61183-2
2137:10.1016/S0300-483X(02)00233-0
2102:10.1016/S0006-291X(82)80083-1
2056:10.1016/S0079-6603(01)70012-8
2023:Molecular biology of the cell
1964:10.1016/S0021-9258(18)82207-4
1558:
763:connective tissue development
698:regulation of gene expression
245:
144:
3809:Cartilage associated protein
3332:10.1021/acs.jmedchem.9b01112
3151:10.1016/0014-5793(94)00907-4
2922:10.1016/0304-4165(87)90220-0
2893:10.1016/0304-4165(86)90325-9
2864:10.1016/0016-5085(85)90563-3
2835:10.1016/0888-7543(91)90057-L
2610:Drug News & Perspectives
1799:10.1016/0162-0134(89)84532-5
1683:10.1016/0888-7543(91)90057-L
1407:and dilated distal airways.
1284:
1242:
733:descending aorta development
633:collagen fibril organization
7:
4587:Genes on human chromosome 5
4293:
1521:
728:ascending aorta development
643:response to steroid hormone
366:stromal cell of endometrium
10:
4613:
4248:D-amino acid dehydrogenase
4151:Glutamate synthase (NADPH)
4109:amino acid oxidoreductases
1467:matrix metalloproteinase-2
1167:
743:protein kinase B signaling
688:osteoblast differentiation
678:blood vessel morphogenesis
4450:
4442:Michaelis–Menten kinetics
4414:
4383:
4352:
4301:
4237:
4214:
4159:
4115:
4018:
3934:
3840:
3790:
3519:
3436:
3416:
2485:10.1016/j.ccr.2008.11.012
2362:10.1007/s13277-012-0501-5
2268:10.1016/j.scr.2012.12.005
2180:10.1080/15287399209531680
1718:10.1007/s00726-003-0012-1
1632:"Mouse PubMed Reference:"
1614:"Human PubMed Reference:"
1436:hypoxia-inducible factors
1155:
1150:
1146:
1139:
1123:
1110:Chr 5: 122.06 – 122.08 Mb
1104:
1081:
1077:
1052:
1048:
1041:
1018:
1014:
989:
985:
978:
965:
961:
946:
942:
933:
920:
916:
901:
897:
888:
875:
871:
856:
852:
843:
828:
821:
817:
801:
683:peptidyl-lysine oxidation
541:
537:
520:
497:
488:
475:
424:
415:
362:
353:
323:
315:
311:
294:
281:
244:
223:
214:
210:
193:
180:
143:
120:
111:
107:
62:
59:
49:
42:
37:
28:
23:
4334:Diffusion-limited enzyme
3369:Medical Subject Headings
1923:10.1074/jbc.272.46.28841
1399:homozygous null models (
1184:protein-lysine 6-oxidase
1168:Not to be confused with
1117:Chr 18: 52.65 – 52.66 Mb
773:DNA biosynthetic process
663:blood vessel development
4229:Glycine cleavage system
4134:Glutamate dehydrogenase
3261:10.1074/jbc.271.12.7113
3219:10.1002/jbmr.5650080203
3087:10.1074/jbc.270.13.7176
3023:10.1126/science.6147899
2316:10.1073/pnas.1206653109
2021:Alberts, Bruce (2002).
1553:Occipital horn syndrome
1386:occipital horn syndrome
571:oxidoreductase activity
3190:10.1006/geno.1993.1203
3117:10.1006/geno.1993.1369
2798:10.1002/hep.1840140635
2000:10.1006/bbrc.2001.4315
1839:10.1074/jbc.M506832200
1318:
1294:
673:elastic fiber assembly
278:18 D1|18 28.22 cM
4427:Eadie–Hofstee diagram
4360:Allosteric regulation
3823:Procollagen peptidase
1461:and is essential for
1430:Clinical significance
1426:and differentiation.
1316:
1292:
1265:residues, as well as
1247:In the yeast species
428:stroma of bone marrow
239:Chromosome 18 (mouse)
4437:Lineweaver–Burk plot
4174:D-amino acid oxidase
1516:extracellular matrix
1367:β-aminopropionitrile
1217:extracellular matrix
617:extracellular matrix
607:extracellular region
137:Chromosome 5 (human)
4253:Amine dehydrogenase
3053:10.1021/bi00516a002
3015:1984Sci...225.1489L
2410:10.1093/jnci/djq569
2307:2012PNAS..10917460E
2172:1992JTEHA..37..411W
1322:Biological function
718:bone mineralization
668:response to hormone
612:extracellular space
4396:Enzyme superfamily
4329:Enzyme promiscuity
3989:Matrix gla protein
3800:Prolyl hydroxylase
2647:Csiszar K (2001).
2530:10.1002/cncr.25768
2256:Stem Cell Research
2046:Csiszar K (2001).
1393:respiratory system
1319:
1295:
1231:cells may promote
1211:. Allysine form
1203:residues into its
923:ENSMUSG00000024529
626:Biological process
590:Cellular component
576:copper ion binding
549:Molecular function
4552:
4551:
4261:
4260:
4241:: other acceptors
4201:Flavin-containing
4183:Copper-containing
4107:1.4) - primarily
4063:
4062:
4014:
4013:
3836:
3835:
3804:Lysyl hydroxylase
3595:basement membrane
3279:Clinical Genetics
3009:(4669): 1489–91.
2978:(11): 6996–7002.
2696:10.1002/jcb.10413
2032:978-0-8153-3218-3
1875:10.1002/jcb.10413
1761:10.1021/bi035338v
1459:basement membrane
1269:(TPQ), a crucial
1182:), also known as
1166:
1165:
1162:
1161:
1135:
1134:
1100:
1099:
1071:
1070:
1037:
1036:
1008:
1007:
974:
973:
955:
954:
929:
928:
910:
909:
884:
883:
865:
864:
813:
812:
658:heart development
653:aorta development
561:metal ion binding
533:
532:
529:
528:
484:
483:
471:
470:
409:
408:
382:periodontal fiber
307:
306:
206:
205:
4604:
4569:
4568:
4560:
4432:Hanes–Woolf plot
4375:Enzyme activator
4370:Enzyme inhibitor
4344:Enzyme catalysis
4288:
4281:
4274:
4265:
4264:
4090:
4083:
4076:
4067:
4066:
3434:
3433:
3425:
3424:
3399:
3392:
3385:
3376:
3375:
3353:
3343:
3326:(5): 2308–2324.
3310:
3273:
3263:
3238:
3201:
3171:
3153:
3128:
3099:
3089:
3064:
3034:
2997:
2987:
2962:
2933:
2904:
2875:
2852:Gastroenterology
2846:
2817:
2780:
2750:
2740:
2715:
2678:
2634:
2633:
2605:
2599:
2598:
2588:
2556:
2550:
2549:
2513:
2507:
2506:
2496:
2464:
2458:
2457:
2440:(21): 10238–41.
2429:
2423:
2422:
2412:
2388:
2382:
2381:
2345:
2339:
2338:
2328:
2318:
2286:
2280:
2279:
2250:
2244:
2243:
2233:
2201:
2192:
2191:
2155:
2149:
2148:
2120:
2114:
2113:
2084:
2078:
2077:
2043:
2037:
2036:
2018:
2012:
2011:
1983:
1977:
1976:
1966:
1957:(14): 10345–50.
1942:
1936:
1935:
1925:
1901:
1895:
1894:
1858:
1852:
1851:
1841:
1832:(52): 42848–55.
1817:
1811:
1810:
1782:
1773:
1772:
1755:(51): 15148–57.
1744:
1738:
1737:
1712:(3–4): 221–226.
1701:
1695:
1694:
1666:
1657:
1656:
1649:
1640:
1639:
1628:
1622:
1621:
1610:
1604:
1594:
1583:
1573:
1505:protein kinase B
1491:formation, both
1307:1,2-benzoquinone
1257:structure. Each
1148:
1147:
1119:
1112:
1095:
1075:
1074:
1066:
1046:
1045:
1042:RefSeq (protein)
1032:
1012:
1011:
1003:
983:
982:
959:
958:
940:
939:
914:
913:
895:
894:
869:
868:
850:
849:
819:
818:
638:lung development
539:
538:
525:
516:
509:
502:
495:
494:
480:
452:efferent ductule
420:
418:Top expressed in
413:
412:
394:ventricular zone
386:cartilage tissue
358:
356:Top expressed in
351:
350:
330:
329:
313:
312:
303:
290:
279:
264:
257:
251:
240:
228:
212:
211:
202:
189:
178:
163:
156:
150:
139:
125:
109:
108:
103:
54:
47:
33:
21:
20:
4612:
4611:
4607:
4606:
4605:
4603:
4602:
4601:
4577:
4576:
4575:
4563:
4555:
4553:
4548:
4460:Oxidoreductases
4446:
4422:Enzyme kinetics
4410:
4406:List of enzymes
4379:
4348:
4319:Catalytic triad
4297:
4292:
4262:
4257:
4233:
4210:
4155:
4111:
4101:oxidoreductases
4099:
4094:
4064:
4059:
4010:
3930:
3832:
3786:
3669:transmembrane:
3515:
3419:
3412:
3403:
3361:
3356:
3080:(13): 7176–82.
2731:(20): 14382–7.
2667:
2642:
2640:Further reading
2637:
2606:
2602:
2565:Cancer Research
2557:
2553:
2524:(10): 2186–91.
2514:
2510:
2465:
2461:
2434:Cancer Research
2430:
2426:
2389:
2385:
2346:
2342:
2301:(43): 17460–5.
2287:
2283:
2251:
2247:
2202:
2195:
2156:
2152:
2131:(2–3): 267–84.
2121:
2117:
2085:
2081:
2066:
2044:
2040:
2033:
2019:
2015:
1984:
1980:
1943:
1939:
1916:(46): 28841–4.
1902:
1898:
1859:
1855:
1818:
1814:
1793:(31): 19022–7.
1783:
1776:
1745:
1741:
1702:
1698:
1667:
1660:
1651:
1650:
1643:
1630:
1629:
1625:
1612:
1611:
1607:
1595:
1586:
1574:
1565:
1561:
1524:
1478:adenocarcinomas
1432:
1324:
1287:
1250:Pichia pastoris
1245:
1173:
1157:View/Edit Mouse
1152:View/Edit Human
1115:
1108:
1105:Location (UCSC)
1091:
1087:
1083:
1062:
1058:
1054:
1028:
1024:
1020:
999:
995:
991:
904:ENSG00000113083
797:
758:cell chemotaxis
621:
585:
566:protein binding
521:
511:
510:
504:
503:
476:
467:
464:ascending aorta
462:
458:
454:
450:
446:
442:
438:
434:
430:
416:
405:
400:
396:
392:
388:
384:
380:
376:
372:
370:Achilles tendon
368:
354:
298:
285:
277:
267:
266:
265:
258:
238:
215:Gene location (
197:
184:
176:
166:
165:
164:
157:
135:
112:Gene location (
101:LOX - orthologs
63:
50:
43:
19:
12:
11:
5:
4610:
4600:
4599:
4597:Copper enzymes
4594:
4592:Lysyl oxidases
4589:
4574:
4573:
4550:
4549:
4547:
4546:
4533:
4520:
4507:
4494:
4481:
4468:
4454:
4452:
4448:
4447:
4445:
4444:
4439:
4434:
4429:
4424:
4418:
4416:
4412:
4411:
4409:
4408:
4403:
4398:
4393:
4387:
4385:
4384:Classification
4381:
4380:
4378:
4377:
4372:
4367:
4362:
4356:
4354:
4350:
4349:
4347:
4346:
4341:
4336:
4331:
4326:
4321:
4316:
4311:
4305:
4303:
4299:
4298:
4291:
4290:
4283:
4276:
4268:
4259:
4258:
4256:
4255:
4250:
4244:
4242:
4235:
4234:
4232:
4231:
4225:
4223:
4212:
4211:
4209:
4208:
4194:
4189:
4176:
4170:
4168:
4157:
4156:
4154:
4153:
4148:
4147:
4146:
4141:
4130:
4128:
4113:
4112:
4097:
4093:
4092:
4085:
4078:
4070:
4061:
4060:
4058:
4057:
4052:
4048:
4047:
4042:
4037:
4032:
4022:
4020:
4016:
4015:
4012:
4011:
4009:
4008:
4007:
4006:
4001:
3991:
3986:
3981:
3976:
3971:
3966:
3961:
3956:
3955:
3954:
3944:
3938:
3936:
3932:
3931:
3929:
3928:
3927:
3926:
3921:
3916:
3906:
3905:
3904:
3899:
3894:
3889:
3879:
3878:
3877:
3872:
3867:
3862:
3857:
3846:
3844:
3838:
3837:
3834:
3833:
3831:
3830:
3825:
3820:
3815:
3806:
3796:
3794:
3788:
3787:
3785:
3784:
3779:
3774:
3773:
3772:
3767:
3757:
3747:
3746:
3745:
3740:
3730:
3720:
3719:
3718:
3713:
3708:
3703:
3689:
3688:
3683:
3678:
3673:
3666:
3665:
3664:
3663:
3658:
3646:
3636:
3635:
3634:
3633:
3628:
3623:
3618:
3613:
3608:
3591:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3550:
3549:
3548:
3543:
3538:
3523:
3521:
3517:
3516:
3514:
3513:
3508:
3503:
3502:
3501:
3496:
3491:
3479:
3472:
3460:
3459:
3458:
3453:
3440:
3438:
3437:Fibril forming
3431:
3422:
3418:Extracellular
3414:
3413:
3410:scleroproteins
3402:
3401:
3394:
3387:
3379:
3373:
3372:
3360:
3359:External links
3357:
3355:
3354:
3311:
3274:
3254:(12): 7113–9.
3239:
3202:
3172:
3129:
3100:
3065:
3047:(13): 3675–9.
3035:
2998:
2963:
2934:
2905:
2876:
2847:
2818:
2792:(6): 1167–73.
2781:
2751:
2716:
2679:
2665:
2643:
2641:
2638:
2636:
2635:
2600:
2551:
2508:
2459:
2424:
2383:
2356:(6): 2379–83.
2350:Tumour Biology
2340:
2281:
2262:(3): 278–287.
2245:
2193:
2150:
2115:
2096:(4): 1546–50.
2079:
2064:
2038:
2031:
2013:
1978:
1937:
1896:
1853:
1812:
1774:
1739:
1696:
1658:
1641:
1623:
1605:
1584:
1562:
1560:
1557:
1556:
1555:
1550:
1548:Menkes disease
1545:
1540:
1535:
1530:
1523:
1520:
1431:
1428:
1382:Menkes disease
1323:
1320:
1286:
1283:
1244:
1241:
1221:osteolathyrism
1164:
1163:
1160:
1159:
1154:
1144:
1143:
1137:
1136:
1133:
1132:
1130:
1128:
1121:
1120:
1113:
1106:
1102:
1101:
1098:
1097:
1079:
1078:
1072:
1069:
1068:
1050:
1049:
1043:
1039:
1038:
1035:
1034:
1016:
1015:
1009:
1006:
1005:
987:
986:
980:
976:
975:
972:
971:
963:
962:
956:
953:
952:
944:
943:
937:
931:
930:
927:
926:
918:
917:
911:
908:
907:
899:
898:
892:
886:
885:
882:
881:
873:
872:
866:
863:
862:
854:
853:
847:
841:
840:
835:
830:
826:
825:
815:
814:
811:
810:
799:
798:
796:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
620:
619:
614:
609:
604:
599:
593:
591:
587:
586:
584:
583:
578:
573:
568:
563:
558:
552:
550:
546:
545:
535:
534:
531:
530:
527:
526:
518:
517:
492:
486:
485:
482:
481:
473:
472:
469:
468:
466:
465:
461:
457:
453:
449:
445:
444:left lung lobe
441:
437:
433:
429:
425:
422:
421:
410:
407:
406:
404:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
360:
359:
347:
346:
338:
327:
321:
320:
317:RNA expression
309:
308:
305:
304:
296:
292:
291:
283:
280:
275:
269:
268:
259:
252:
246:
242:
241:
236:
230:
229:
221:
220:
208:
207:
204:
203:
195:
191:
190:
182:
179:
174:
168:
167:
158:
151:
145:
141:
140:
133:
127:
126:
118:
117:
105:
104:
61:
57:
56:
48:
40:
39:
35:
34:
26:
25:
17:
9:
6:
4:
3:
2:
4609:
4598:
4595:
4593:
4590:
4588:
4585:
4584:
4582:
4572:
4567:
4562:
4561:
4558:
4544:
4540:
4539:
4534:
4531:
4527:
4526:
4521:
4518:
4514:
4513:
4508:
4505:
4501:
4500:
4495:
4492:
4488:
4487:
4482:
4479:
4475:
4474:
4469:
4466:
4462:
4461:
4456:
4455:
4453:
4449:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4423:
4420:
4419:
4417:
4413:
4407:
4404:
4402:
4401:Enzyme family
4399:
4397:
4394:
4392:
4389:
4388:
4386:
4382:
4376:
4373:
4371:
4368:
4366:
4365:Cooperativity
4363:
4361:
4358:
4357:
4355:
4351:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4324:Oxyanion hole
4322:
4320:
4317:
4315:
4312:
4310:
4307:
4306:
4304:
4300:
4296:
4289:
4284:
4282:
4277:
4275:
4270:
4269:
4266:
4254:
4251:
4249:
4246:
4245:
4243:
4240:
4236:
4230:
4227:
4226:
4224:
4221:
4217:
4213:
4206:
4202:
4198:
4197:Primary-amine
4195:
4193:
4190:
4188:
4184:
4180:
4179:Amine oxidase
4177:
4175:
4172:
4171:
4169:
4166:
4162:
4158:
4152:
4149:
4145:
4142:
4140:
4137:
4136:
4135:
4132:
4131:
4129:
4126:
4122:
4118:
4114:
4110:
4106:
4102:
4091:
4086:
4084:
4079:
4077:
4072:
4071:
4068:
4056:
4053:
4050:
4049:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4027:
4024:
4023:
4021:
4017:
4005:
4002:
4000:
3997:
3996:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3970:
3967:
3965:
3962:
3960:
3957:
3953:
3950:
3949:
3948:
3945:
3943:
3940:
3939:
3937:
3933:
3925:
3922:
3920:
3917:
3915:
3912:
3911:
3910:
3907:
3903:
3900:
3898:
3895:
3893:
3890:
3888:
3885:
3884:
3883:
3880:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3852:
3851:
3848:
3847:
3845:
3843:
3839:
3829:
3828:Lysyl oxidase
3826:
3824:
3821:
3819:
3816:
3814:
3810:
3807:
3805:
3801:
3798:
3797:
3795:
3793:
3789:
3783:
3780:
3778:
3775:
3771:
3768:
3766:
3763:
3762:
3761:
3758:
3755:
3751:
3748:
3744:
3741:
3739:
3736:
3735:
3734:
3731:
3728:
3724:
3721:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3698:
3697:
3696:
3691:
3690:
3687:
3684:
3682:
3679:
3677:
3674:
3672:
3668:
3667:
3662:
3659:
3657:
3654:
3653:
3652:
3651:
3647:
3645:
3641:
3638:
3637:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3603:
3602:
3601:
3596:
3593:
3592:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3558:
3554:
3551:
3547:
3544:
3542:
3539:
3537:
3534:
3533:
3532:
3528:
3525:
3524:
3522:
3518:
3512:
3509:
3507:
3504:
3500:
3497:
3495:
3492:
3490:
3487:
3486:
3485:
3484:
3480:
3478:
3477:
3473:
3470:
3466:
3465:
3461:
3457:
3454:
3452:
3449:
3448:
3447:
3446:
3442:
3441:
3439:
3435:
3432:
3430:
3426:
3423:
3421:
3415:
3411:
3407:
3400:
3395:
3393:
3388:
3386:
3381:
3380:
3377:
3370:
3366:
3365:Lysyl+Oxidase
3363:
3362:
3351:
3347:
3342:
3337:
3333:
3329:
3325:
3321:
3317:
3312:
3308:
3304:
3300:
3296:
3292:
3288:
3285:(2): 109–14.
3284:
3280:
3275:
3271:
3267:
3262:
3257:
3253:
3249:
3245:
3240:
3236:
3232:
3228:
3224:
3220:
3216:
3212:
3208:
3203:
3199:
3195:
3191:
3187:
3183:
3179:
3173:
3169:
3165:
3161:
3157:
3152:
3147:
3143:
3139:
3135:
3130:
3126:
3122:
3118:
3114:
3110:
3106:
3101:
3097:
3093:
3088:
3083:
3079:
3075:
3071:
3066:
3062:
3058:
3054:
3050:
3046:
3042:
3036:
3032:
3028:
3024:
3020:
3016:
3012:
3008:
3004:
2999:
2995:
2991:
2986:
2981:
2977:
2973:
2969:
2964:
2960:
2956:
2952:
2948:
2944:
2940:
2935:
2931:
2927:
2923:
2919:
2916:(3): 339–48.
2915:
2911:
2906:
2902:
2898:
2894:
2890:
2887:(2): 326–34.
2886:
2882:
2877:
2873:
2869:
2865:
2861:
2858:(4): 709–15.
2857:
2853:
2848:
2844:
2840:
2836:
2832:
2829:(3): 508–16.
2828:
2824:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2791:
2787:
2782:
2778:
2774:
2770:
2766:
2762:
2758:
2752:
2748:
2744:
2739:
2734:
2730:
2726:
2722:
2717:
2713:
2709:
2705:
2701:
2697:
2693:
2690:(4): 660–72.
2689:
2685:
2680:
2676:
2672:
2668:
2666:9780125400701
2662:
2658:
2654:
2650:
2645:
2644:
2631:
2627:
2623:
2619:
2616:(4): 218–24.
2615:
2611:
2604:
2596:
2592:
2587:
2582:
2578:
2574:
2571:(2): 583–94.
2570:
2566:
2562:
2555:
2547:
2543:
2539:
2535:
2531:
2527:
2523:
2519:
2512:
2504:
2500:
2495:
2490:
2486:
2482:
2478:
2474:
2470:
2463:
2455:
2451:
2447:
2443:
2439:
2435:
2428:
2420:
2416:
2411:
2406:
2403:(5): 407–24.
2402:
2398:
2394:
2387:
2379:
2375:
2371:
2367:
2363:
2359:
2355:
2351:
2344:
2336:
2332:
2327:
2322:
2317:
2312:
2308:
2304:
2300:
2296:
2292:
2285:
2277:
2273:
2269:
2265:
2261:
2257:
2249:
2241:
2237:
2232:
2227:
2223:
2219:
2216:(4): 927–36.
2215:
2211:
2207:
2200:
2198:
2189:
2185:
2181:
2177:
2173:
2169:
2166:(3): 411–23.
2165:
2161:
2154:
2146:
2142:
2138:
2134:
2130:
2126:
2119:
2111:
2107:
2103:
2099:
2095:
2091:
2083:
2075:
2071:
2067:
2065:9780125400701
2061:
2057:
2053:
2049:
2042:
2034:
2028:
2024:
2017:
2009:
2005:
2001:
1997:
1993:
1989:
1982:
1974:
1970:
1965:
1960:
1956:
1952:
1948:
1941:
1933:
1929:
1924:
1919:
1915:
1911:
1907:
1900:
1892:
1888:
1884:
1880:
1876:
1872:
1869:(4): 660–72.
1868:
1864:
1857:
1849:
1845:
1840:
1835:
1831:
1827:
1823:
1816:
1808:
1804:
1800:
1796:
1792:
1788:
1781:
1779:
1770:
1766:
1762:
1758:
1754:
1750:
1743:
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1700:
1692:
1688:
1684:
1680:
1677:(3): 508–16.
1676:
1672:
1665:
1663:
1654:
1648:
1646:
1637:
1633:
1627:
1619:
1615:
1609:
1602:
1598:
1593:
1591:
1589:
1581:
1577:
1572:
1570:
1568:
1563:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1534:
1531:
1529:
1526:
1525:
1519:
1517:
1512:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1481:
1479:
1475:
1470:
1468:
1464:
1460:
1456:
1451:
1447:
1443:
1441:
1437:
1427:
1425:
1421:
1417:
1413:
1408:
1406:
1402:
1398:
1394:
1389:
1387:
1383:
1378:
1376:
1372:
1368:
1362:
1360:
1356:
1355:pyridinolines
1351:
1349:
1348:cross-linking
1345:
1341:
1337:
1333:
1329:
1315:
1311:
1308:
1304:
1300:
1299:lysyl residue
1291:
1282:
1279:
1274:
1272:
1268:
1264:
1260:
1256:
1252:
1251:
1240:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1198:
1195:
1194:
1189:
1185:
1181:
1177:
1176:Lysyl oxidase
1171:
1158:
1153:
1149:
1145:
1142:
1138:
1131:
1129:
1126:
1122:
1118:
1114:
1111:
1107:
1103:
1096:
1094:
1090:
1086:
1080:
1076:
1073:
1067:
1065:
1061:
1057:
1051:
1047:
1044:
1040:
1033:
1031:
1027:
1023:
1017:
1013:
1010:
1004:
1002:
998:
994:
988:
984:
981:
979:RefSeq (mRNA)
977:
970:
969:
964:
960:
957:
951:
950:
945:
941:
938:
936:
932:
925:
924:
919:
915:
912:
906:
905:
900:
896:
893:
891:
887:
880:
879:
874:
870:
867:
861:
860:
855:
851:
848:
846:
842:
839:
836:
834:
831:
827:
824:
820:
816:
809:
805:
800:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
648:wound healing
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
553:
551:
548:
547:
544:
543:Gene ontology
540:
536:
524:
519:
515:
508:
501:
496:
493:
491:
487:
479:
474:
463:
459:
455:
451:
447:
443:
440:body of femur
439:
435:
431:
427:
426:
423:
419:
414:
411:
402:skin of thigh
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
364:
361:
357:
352:
349:
348:
345:
343:
339:
337:
336:
332:
331:
328:
326:
322:
318:
314:
310:
302:
297:
293:
289:
284:
274:
270:
263:
256:
250:
243:
235:
231:
227:
222:
218:
213:
209:
201:
196:
192:
188:
183:
173:
169:
162:
155:
149:
142:
138:
132:
128:
124:
119:
115:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
66:
58:
53:
46:
41:
36:
32:
27:
22:
16:
4538:Translocases
4535:
4522:
4509:
4496:
4483:
4473:Transferases
4470:
4457:
4314:Binding site
4186:
3952:Tropoelastin
3908:
3881:
3849:
3827:
3759:
3749:
3732:
3722:
3693:
3648:
3598:
3552:
3530:
3481:
3474:
3462:
3443:
3323:
3319:
3282:
3278:
3251:
3247:
3213:(2): 133–7.
3210:
3206:
3184:(2): 401–6.
3181:
3177:
3144:(3): 433–6.
3141:
3138:FEBS Letters
3137:
3111:(3): 544–8.
3108:
3104:
3077:
3073:
3044:
3041:Biochemistry
3040:
3006:
3002:
2975:
2971:
2942:
2938:
2913:
2909:
2884:
2880:
2855:
2851:
2826:
2822:
2789:
2785:
2763:(3): 242–8.
2760:
2756:
2728:
2724:
2687:
2683:
2648:
2613:
2609:
2603:
2568:
2564:
2554:
2521:
2517:
2511:
2479:(1): 35–44.
2476:
2472:
2462:
2437:
2433:
2427:
2400:
2396:
2386:
2353:
2349:
2343:
2298:
2294:
2284:
2259:
2255:
2248:
2213:
2209:
2163:
2159:
2153:
2128:
2124:
2118:
2093:
2089:
2082:
2047:
2041:
2022:
2016:
1994:(1): 193–9.
1991:
1987:
1981:
1954:
1950:
1940:
1913:
1909:
1899:
1866:
1862:
1856:
1829:
1825:
1815:
1790:
1786:
1752:
1749:Biochemistry
1748:
1742:
1709:
1705:
1699:
1674:
1670:
1635:
1626:
1617:
1608:
1513:
1496:
1492:
1489:blood vessel
1485:angiogenesis
1482:
1471:
1452:
1448:
1444:
1433:
1409:
1400:
1396:
1390:
1379:
1363:
1352:
1338:residues in
1325:
1296:
1278:chromosome 5
1275:
1248:
1246:
1225:upregulation
1192:
1191:
1183:
1179:
1175:
1174:
1170:Lipoxygenase
1089:NP_001273111
1085:NP_001273110
1082:
1060:NP_001304002
1056:NP_001171573
1053:
1030:NM_001286182
1026:NM_001286181
1019:
1001:NM_001317073
997:NM_001178102
990:
966:
947:
921:
902:
876:
857:
837:
832:
340:
333:
198:122,078,413
185:122,063,195
60:External IDs
15:
4309:Active site
4030:Cytokeratin
3959:Vitronectin
3640:multiplexin
2473:Cancer Cell
1706:Amino Acids
1474:lung cancer
1424:cell growth
1255:homodimeric
1213:cross-links
1207:derivative
398:skin of arm
390:pericardium
378:skin of hip
299:52,662,939
286:52,649,139
38:Identifiers
4581:Categories
4512:Isomerases
4486:Hydrolases
4353:Regulation
3661:Endostatin
3650:type XVIII
2945:: 114–22.
2786:Hepatology
2125:Toxicology
1603:, May 2017
1582:, May 2017
1559:References
1416:stem cells
1359:desmosines
1233:metastasis
432:belly cord
344:(ortholog)
81:HomoloGene
4391:EC number
4220:disulfide
4205:Monoamine
4040:Reticulin
3733:type VIII
1412:adipocyte
1405:emphysema
1375:aneurysms
1371:lathyrism
1285:Mechanism
1263:histidine
1243:Structure
1237:cancerous
1093:NP_034858
1064:NP_002308
1022:NM_010728
993:NM_002317
823:Orthologs
89:GeneCards
4415:Kinetics
4339:Cofactor
4302:Activity
4222:acceptor
4167:acceptor
4127:acceptor
4055:diseases
4051:See also
3994:Tectorin
3813:Leprecan
3723:type VII
3553:type XII
3476:type III
3429:Collagen
3350:31430136
3307:36246895
3235:21904627
3178:Genomics
3168:23360856
3105:Genomics
2823:Genomics
2814:25820738
2712:23651213
2704:12577300
2675:11642359
2630:18560621
2595:23188504
2546:25144943
2538:21523732
2503:19111879
2454:17079439
2419:21282564
2378:14633716
2370:22948781
2335:23033492
2276:23395997
2240:16192629
2145:12135629
2074:11642359
2008:11178979
1891:23651213
1883:12577300
1848:16251195
1769:14690425
1734:28837698
1726:14661085
1671:Genomics
1599:–
1578:–
1522:See also
1497:in vitro
1455:collagen
1340:collagen
1271:cofactor
1209:allysine
1205:aldehyde
1186:, is an
1141:Wikidata
802:Sources:
597:collagen
436:calvaria
4571:Biology
4525:Ligases
4295:Enzymes
4192:Diamine
4035:Gelatin
4026:Keratin
3974:Decorin
3947:Elastin
3842:Laminin
3818:ADAMTS2
3792:Enzymes
3782:COL28A1
3777:COL27A1
3770:COL11A2
3765:COL11A1
3760:type XI
3754:COL10A1
3695:type VI
3692:other:
3686:COL25A1
3681:COL23A1
3676:COL17A1
3671:COL13A1
3656:COL18A1
3644:COL15A1
3600:type IV
3588:COL22A1
3583:COL21A1
3578:COL20A1
3573:COL19A1
3568:COL16A1
3563:COL14A1
3557:COL12A1
3531:type IX
3511:COL26A1
3506:COL24A1
3464:type II
3406:Protein
3341:7073924
3299:9111998
3270:8636146
3227:8442432
3198:8100215
3160:8082810
3125:7902322
3096:7706256
3061:6912069
3031:6147899
3011:Bibcode
3003:Science
2994:6144680
2959:6127904
2930:3120785
2901:2874833
2872:2863189
2843:1685472
2806:1683640
2777:1357535
2747:1352776
2586:3548904
2494:3050620
2326:3491529
2303:Bibcode
2231:1603668
2188:1359158
2168:Bibcode
2110:6129847
1973:8098038
1932:9360949
1807:1977746
1691:1685472
1601:Ensembl
1580:Ensembl
1493:in vivo
1457:in the
1440:hypoxic
1401:Lox -/-
1344:elastin
1328:oxidase
1303:quinone
1259:monomer
935:UniProt
890:Ensembl
829:Species
808:QuickGO
602:nucleus
319:pattern
45:Aliases
4557:Portal
4499:Lyases
4239:1.4.99
4165:oxygen
3979:FAM20C
3750:type X
3743:COL8A2
3738:COL8A1
3727:COL7A1
3716:COL6A5
3711:COL6A3
3706:COL6A2
3701:COL6A1
3631:COL4A6
3626:COL4A5
3621:COL4A4
3616:COL4A3
3611:COL4A2
3606:COL4A1
3546:COL9A3
3541:COL9A2
3536:COL9A1
3499:COL5A3
3494:COL5A2
3489:COL5A1
3483:type V
3469:COL2A1
3456:COL1A2
3451:COL1A1
3445:type I
3420:matrix
3371:(MeSH)
3348:
3338:
3305:
3297:
3268:
3233:
3225:
3196:
3166:
3158:
3123:
3094:
3059:
3029:
2992:
2957:
2928:
2899:
2870:
2841:
2812:
2804:
2775:
2757:Matrix
2745:
2710:
2702:
2673:
2663:
2628:
2593:
2583:
2544:
2536:
2518:Cancer
2501:
2491:
2452:
2417:
2376:
2368:
2333:
2323:
2274:
2238:
2228:
2186:
2143:
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2072:
2062:
2029:
2006:
1971:
1930:
1889:
1881:
1846:
1805:
1767:
1732:
1724:
1689:
1509:PDGFRB
1463:CD11b+
1336:lysine
1332:enzyme
1326:Lysyl
1201:lysine
1188:enzyme
1127:search
1125:PubMed
968:P28301
949:P28300
845:Entrez
490:BioGPS
456:dermis
177:5q23.1
69:153455
4451:Types
4216:1.4.4
4187:Lysyl
4161:1.4.3
4144:GLUD2
4139:GLUD1
4117:1.4.1
4096:CH-NH
4019:Other
4004:TECTB
3999:TECTA
3969:FREM2
3964:FRAS1
3942:ALCAM
3935:Other
3924:LAMC3
3919:LAMC2
3914:LAMC1
3909:gamma
3902:LAMB4
3897:LAMB3
3892:LAMB2
3887:LAMB1
3875:LAMA5
3870:LAMA4
3865:LAMA3
3860:LAMA2
3855:LAMA1
3850:alpha
3527:FACIT
3520:Other
3303:S2CID
3231:S2CID
3164:S2CID
2810:S2CID
2708:S2CID
2542:S2CID
2374:S2CID
1887:S2CID
1730:S2CID
1543:LOXL4
1538:LOXL3
1533:LOXL2
1528:LOXL1
1487:, or
1229:tumor
878:16948
838:Mouse
833:Human
804:Amigo
460:ankle
448:molar
374:tibia
342:Mouse
335:Human
282:Start
217:Mouse
181:Start
114:Human
77:96817
4543:list
4536:EC7
4530:list
4523:EC6
4517:list
4510:EC5
4504:list
4497:EC4
4491:list
4484:EC3
4478:list
4471:EC2
4465:list
4458:EC1
4199:)) (
4125:NADP
3984:ECM1
3882:beta
3346:PMID
3295:PMID
3266:PMID
3223:PMID
3194:PMID
3156:PMID
3121:PMID
3092:PMID
3057:PMID
3027:PMID
2990:PMID
2955:PMID
2926:PMID
2897:PMID
2868:PMID
2839:PMID
2802:PMID
2773:PMID
2743:PMID
2700:PMID
2671:PMID
2661:ISBN
2626:PMID
2591:PMID
2534:PMID
2499:PMID
2450:PMID
2415:PMID
2366:PMID
2331:PMID
2272:PMID
2236:PMID
2184:PMID
2141:PMID
2106:PMID
2070:PMID
2060:ISBN
2027:ISBN
2004:PMID
1969:PMID
1928:PMID
1879:PMID
1844:PMID
1803:PMID
1765:PMID
1722:PMID
1687:PMID
1495:and
1384:and
1342:and
1197:gene
859:4015
325:Bgee
273:Band
234:Chr.
172:Band
131:Chr.
85:1741
65:OMIM
4207:)))
4121:NAD
3336:PMC
3328:doi
3287:doi
3256:doi
3252:271
3215:doi
3186:doi
3146:doi
3142:351
3113:doi
3082:doi
3078:270
3049:doi
3019:doi
3007:225
2980:doi
2976:259
2947:doi
2943:660
2918:doi
2914:926
2889:doi
2885:883
2860:doi
2831:doi
2794:doi
2765:doi
2733:doi
2729:267
2692:doi
2653:doi
2618:doi
2581:PMC
2573:doi
2526:doi
2522:117
2489:PMC
2481:doi
2442:doi
2405:doi
2401:103
2358:doi
2321:PMC
2311:doi
2299:109
2264:doi
2226:PMC
2218:doi
2214:167
2176:doi
2133:doi
2129:177
2098:doi
2094:108
2052:doi
1996:doi
1992:281
1959:doi
1955:268
1918:doi
1914:272
1871:doi
1834:doi
1830:280
1795:doi
1791:265
1757:doi
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1679:doi
1397:Lox
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