35:) means excluding the exposure in a time period before registration of an outcome. It may be motivated by that the actual outcome had actually occurred before the registration of it, and that the last exposure before registration did not contribute to the case.
53:, that is, when a treatment for the first symptoms of a disease or other outcome appear to cause the outcome. Protopathic bias is a potential bias when there is a lag time from the first symptoms and start of treatment before actual diagnosis.
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Tamim H, Monfared AA, LeLorier J (March 2007). "Application of lag-time into exposure definitions to control for protopathic bias".
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Feinstein AR, Horwitz RI (November 1978). "A critique of the statistical evidence associating estrogens with endometrial cancer".
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