320:
297:
219:
194:
571:
326:
225:
3610:
31:
1575:
Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP (August 2000). "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation".
57:
2427:
Santin AD, Cane' S, Bellone S, Bignotti E, Palmieri M, De Las Casas LE, et al. (August 2004). "The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells".
2621:
Diamandis EP, Scorilas A, Kishi T, Blennow K, Luo LY, Soosaipillai A, et al. (March 2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with
Alzheimer's disease and frontotemporal dementia".
1178:, other skin-expressed proteases, also cleave corneodesmosomal proteins. KLK5 is able to undergo autoactivation, as well as activating KLK7 and KLK14, suggesting a KLK skin cascade is responsible for coordinating desquamation.
2228:
Descargues P, Deraison C, Bonnart C, Kreft M, Kishibe M, Ishida-Yamamoto A, et al. (January 2005). "Spink5-deficient mice mimic
Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity".
2340:
Talieri M, Diamandis EP, Gourgiotis D, Mathioudaki K, Scorilas A (January 2004). "Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma".
333:
232:
2498:
Planque C, de Monte M, Guyetant S, Rollin J, Desmazes C, Panel V, et al. (April 2005). "KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer".
2313:
Dong Y, Kaushal A, Brattsand M, Nicklin J, Clements JA (May 2003). "Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers".
2539:
Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region".
1846:
Egelrud T, Brattsand M, Kreutzmann P, Walden M, Vitzithum K, Marx UC, et al. (December 2005). "hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6".
2101:
Komatsu N, Saijoh K, Kuk C, Liu AC, Khan S, Shirasaki F, et al. (June 2007). "Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients".
2463:
Rezze GG, Fregnani JH, Duprat J, Landman G (March 2011). "Cell adhesion and communication proteins are differentially expressed in melanoma progression model".
3264:
2696:"LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum"
1536:"Stratum corneum chymotryptic enzyme: a proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation"
779:
155:
3124:
760:
1249:. These diseases are characterised by excessively dry, scaly and inflamed skin, due to a disruption of skin homeostasis and correct barrier function.
2864:
1365:
1347:
2274:"Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome"
54:
2025:
Skytt A, Strömqvist M, Egelrud T (June 1995). "Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme".
2384:
Johnson SK, Ramani VC, Hennings L, Haun RS (May 2007). "Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin".
1007:
1014:
1171:. For example, KLK7 expression is highly downregulated at acral surfaces where desquamation is delayed and the epidermis is thick.
2146:"Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis"
2884:
1520:
1750:"Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes"
3630:
1330:
1088:
and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human
1709:"Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7"
1385:"Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase"
1128:, requiring proteolytic cleavage of the short N-terminal pro-region to liberate activated enzyme. This may be performed by
2857:
1309:
1799:"LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction"
1167:, the shedding of corneocytes from the outer layer of the epidermis. This indicates a role for KLK7 in maintaining skin
1613:"Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome"
3329:
2842:
1945:"Antileukoprotease inhibits stratum corneum chymotryptic enzyme. Evidence for a regulative function in desquamation"
319:
1334:
1313:
296:
2850:
824:
2774:"Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7"
1474:"Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005".
3485:
2653:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
218:
193:
805:
3084:
1198:
1182:
135:
2694:
Ishida-Yamamoto A, Deraison C, Bonnart C, Bitoun E, Robinson R, O'Brien TJ, et al. (February 2005).
2272:
Descargues P, Deraison C, Prost C, Fraitag S, Mazereeuw-Hautier J, D'Alessio M, et al. (July 2006).
3600:
2568:
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002).
332:
231:
2060:
Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, et al. (September 2006).
3586:
3573:
3560:
3547:
3534:
3521:
3508:
3470:
2999:
2984:
325:
224:
122:
3480:
3434:
3377:
2881:
961:
957:
906:
902:
143:
1889:
Meyer-Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, et al. (October 2010).
3382:
3274:
3239:
3234:
2651:
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004).
1984:
Galliano MF, Toulza E, Gallinaro H, Jonca N, Ishida-Yamamoto A, Serre G, Guerrin M (March 2006).
1797:
Deraison C, Bonnart C, Lopez F, Besson C, Robinson R, Jayakumar A, et al. (September 2007).
2570:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
2062:"Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences"
1986:"A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis"
990:
969:
965:
931:
910:
898:
2729:
Yamasaki K, Schauber J, Coda A, Lin H, Dorschner RA, Schechter NM, et al. (October 2006).
2144:
Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, et al. (July 2004).
1156:
2731:"Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin"
3403:
3322:
3229:
3079:
1611:
Sales KU, Masedunskas A, Bey AL, Rasmussen AL, Weigert R, List K, et al. (August 2010).
1224:. Analysis of peptide substrate hydrolysis indicates a strong preference for tyrosine at P1.
207:
2772:
Debela M, Hess P, Magdolen V, Schechter NM, Steiner T, Huber R, et al. (October 2007).
1424:
Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006).
3475:
3219:
2837:
2785:
2581:
1212:
KLK7 is a chymotrypsin-like serine protease, preferring to cleave proteins at the residues
1425:
163:
8:
3439:
3119:
3109:
2926:
2921:
1891:"Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases"
1748:
Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022).
1707:
Caubet C, Jonca N, Brattsand M, Guerrin M, Bernard D, Schmidt R, et al. (May 2004).
2789:
2585:
3635:
3372:
2808:
2773:
2760:
2409:
2366:
2254:
2210:
2126:
1917:
1890:
1871:
1823:
1798:
1774:
1749:
1637:
1612:
1499:
1456:
1426:"A comprehensive nomenclature for serine proteases with homology to tissue kallikreins"
1246:
1121:
167:
2872:
2677:
2652:
2635:
2604:
2569:
2552:
2185:
Ekholm E, Egelrud T (April 1999). "Stratum corneum chymotryptic enzyme in psoriasis".
1589:
1401:
1384:
1383:
Hansson L, Strömqvist M, Bäckman A, Wallbrandt P, Carlstein A, Egelrud T (July 1994).
694:
689:
684:
679:
663:
658:
653:
648:
632:
627:
622:
617:
612:
3101:
2813:
2752:
2717:
2712:
2695:
2682:
2639:
2609:
2556:
2516:
2480:
2445:
2401:
2358:
2322:
2295:
2246:
2202:
2167:
2162:
2145:
2118:
2114:
2083:
2042:
2007:
1966:
1922:
1863:
1859:
1828:
1779:
1730:
1725:
1708:
1686:
1681:
1664:
1642:
1593:
1557:
1491:
1448:
1406:
1270:
1238:
115:
47:
2764:
2258:
2214:
1875:
1503:
147:
3418:
3413:
3387:
3315:
2893:
2803:
2793:
2742:
2707:
2672:
2664:
2631:
2599:
2589:
2548:
2508:
2472:
2437:
2413:
2393:
2370:
2350:
2285:
2238:
2194:
2157:
2110:
2073:
2034:
1997:
1956:
1912:
1902:
1855:
1818:
1810:
1769:
1761:
1720:
1676:
1632:
1624:
1585:
1547:
1483:
1440:
1396:
1125:
1085:
412:
343:
287:
242:
2476:
2130:
1460:
1284:
by excessive cleavage of cell junction proteins. It may also be underexpressed in
3465:
3449:
3362:
3134:
3129:
2901:
2877:
1274:
1160:
1074:
387:
171:
2441:
1370:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1352:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3614:
3503:
3444:
2778:
Proceedings of the
National Academy of Sciences of the United States of America
2574:
Proceedings of the
National Academy of Sciences of the United States of America
2512:
1765:
1262:
1148:
488:
3624:
3408:
3367:
3279:
3152:
3141:
2873:
1961:
1944:
1552:
1535:
1266:
1217:
1093:
599:
2798:
1907:
1814:
548:
426:
3357:
3175:
3069:
2911:
2817:
2756:
2721:
2686:
2643:
2613:
2594:
2560:
2520:
2484:
2449:
2405:
2362:
2326:
2299:
2290:
2273:
2250:
2206:
2171:
2122:
2087:
2078:
2061:
2038:
2011:
2002:
1985:
1943:
Franzke CW, Baici A, Bartels J, Christophers E, Wiedow O (September 1996).
1926:
1867:
1832:
1783:
1734:
1690:
1646:
1597:
1495:
1452:
1164:
570:
405:
184:
2747:
2730:
2198:
2046:
1970:
1561:
1410:
1237:
Dysregulation of KLK7 has been linked to several skin disorders including
1054:
1049:
3581:
3516:
3352:
3294:
3289:
2938:
2354:
1285:
1168:
1144:
873:
854:
850:
1663:
Brattsand M, Stefansson K, Lundh C, Haasum Y, Egelrud T (January 2005).
1487:
1444:
3256:
3198:
2979:
2974:
2954:
2668:
2397:
1258:
1133:
1089:
304:
201:
151:
1092:
family, which includes fifteen homologous serine proteases located on
92:
88:
84:
80:
76:
3555:
3529:
3284:
3270:
3089:
2969:
2959:
2339:
1242:
1152:
724:
371:
358:
270:
257:
159:
2693:
3609:
3170:
3165:
3114:
2964:
2949:
2916:
2242:
1628:
1278:
1213:
1108:
gene results in two transcript variants encoding the same protein.
1038:
1574:
1382:
3224:
3214:
3160:
3074:
2906:
1281:
1221:
1117:
836:
791:
709:
705:
2059:
1845:
139:
3568:
3338:
3251:
3193:
2833:
1942:
1206:
1194:
1190:
1022:
746:
579:
2426:
2271:
2227:
2143:
1662:
3542:
3260:
3246:
3185:
3059:
3054:
3049:
3044:
3039:
3034:
2620:
2567:
2497:
1888:
1665:"A proteolytic cascade of kallikreins in the stratum corneum"
1186:
1181:
KLK7 activity is regulated by a number of endogenous protein
1175:
2650:
1983:
1610:
3029:
3024:
3014:
3009:
3004:
2994:
2989:
2771:
2312:
1706:
1202:
1151:. These proteins constitute the extracellular component of
1129:
1081:
3307:
2538:
2462:
1796:
1423:
2383:
1747:
395:
2728:
680:
positive regulation of antibacterial peptide production
30:
2024:
3598:
2836:
online database for peptidases and their inhibitors:
560:
2501:
2100:
2027:
1155:, intercellular cohesive structures which link the
1521:"Entrez Gene: KLK7 kallikrein-related peptidase 7"
1326:
1324:
1322:
1305:
1303:
1301:
1163:. Proteolysis of corneodesmosomes is required for
126:, PRSS6, SCCE, hK7, kallikrein related peptidase 7
342:
241:
3622:
1702:
1700:
1533:
1319:
1298:
1257:Overexpression of KLK7 may provide a route for
18:Protein-coding gene in the species Homo sapiens
1331:GRCm38: Ensembl release 89: ENSMUSG00000030713
3323:
2858:
2184:
1697:
2456:
2420:
2377:
2333:
2306:
2221:
2178:
2094:
1568:
1467:
1417:
1310:GRCh38: Ensembl release 89: ENSG00000169035
3330:
3316:
2865:
2851:
1938:
1936:
1658:
1656:
1527:
1376:
2807:
2797:
2746:
2711:
2676:
2603:
2593:
2289:
2161:
2077:
2001:
1960:
1916:
1906:
1822:
1773:
1724:
1680:
1636:
1551:
1400:
2700:The Journal of Investigative Dermatology
2278:The Journal of Investigative Dermatology
2150:The Journal of Investigative Dermatology
1713:The Journal of Investigative Dermatology
1669:The Journal of Investigative Dermatology
1515:
1513:
1227:
1933:
1653:
1084:. KLK7 was initially purified from the
3623:
2878:serine proteases/serine endopeptidases
1882:
1839:
1790:
3311:
2846:
2053:
2018:
1977:
1604:
1510:
347:
308:
303:
246:
205:
200:
2491:
1209:ions are also able to inhibit KLK7.
1143:Once active, KLK7 is able to cleave
2265:
2187:Archives of Dermatological Research
2137:
2066:The Journal of Biological Chemistry
1990:The Journal of Biological Chemistry
1949:The Journal of Biological Chemistry
1895:The Journal of Biological Chemistry
1389:The Journal of Biological Chemistry
13:
2531:
1848:The British Journal of Dermatology
628:serine-type endopeptidase activity
14:
3647:
2826:
2636:10.1016/j.clinbiochem.2003.11.012
1077:that in humans is encoded by the
3608:
2713:10.1111/j.0022-202X.2004.23583.x
2163:10.1111/j.0022-202X.2004.22708.x
2115:10.1111/j.1600-0625.2007.00562.x
1860:10.1111/j.1365-2133.2005.06834.x
1726:10.1111/j.0022-202X.2004.22512.x
1682:10.1111/j.0022-202X.2004.23547.x
1116:KLK7 is secreted as an inactive
685:extracellular matrix disassembly
569:
331:
324:
318:
295:
230:
223:
217:
192:
29:
1741:
1534:Lundström A, Egelrud T (1991).
1232:
1358:
1340:
1067:Kallikrein-related peptidase 7
618:serine-type peptidase activity
580:More reference expression data
549:More reference expression data
507:basilar part of occipital bone
1:
3090:Urinary plasminogen activator
2553:10.1016/S0378-1119(00)00382-6
2477:10.1016/j.humpath.2010.09.004
1803:Molecular Biology of the Cell
1590:10.1016/S0378-1119(00)00280-8
1402:10.1016/S0021-9258(17)32185-3
1291:
633:metalloendopeptidase activity
316:
215:
3631:Genes on human chromosome 19
3085:Tissue plasminogen activator
1199:alpha-2-Macroglobulin-like 1
1104:Alternative splicing of the
7:
3337:
2442:10.1016/j.ygyno.2004.05.023
1111:
10:
3652:
2513:10.1016/j.bbrc.2005.02.100
2343:Thrombosis and Haemostasis
1766:10.1172/jci.insight.159762
1540:Acta Dermato-Venereologica
3494:
3486:Michaelis–Menten kinetics
3458:
3427:
3396:
3345:
3207:
3184:
3176:Proteinase 3/Myeloblastin
3150:
3100:
2937:
2892:
1482:(6): 635–824. June 2006.
1366:"Mouse PubMed Reference:"
1348:"Human PubMed Reference:"
1252:
1159:of adjacent cells in the
1053:
1048:
1044:
1037:
1021:
1002:
987:
983:
954:
950:
943:
928:
924:
895:
891:
884:
871:
867:
848:
844:
835:
822:
818:
803:
799:
790:
777:
773:
758:
754:
745:
730:
723:
719:
703:
598:
594:
577:
568:
559:
546:
495:
486:
433:
424:
394:
386:
382:
365:
352:
315:
294:
285:
281:
264:
251:
214:
191:
182:
178:
133:
130:
120:
113:
108:
73:
68:
51:
46:
41:
37:
28:
23:
3378:Diffusion-limited enzyme
2315:Clinical Cancer Research
2103:Experimental Dermatology
1962:10.1074/jbc.271.36.21886
1553:10.2340/0001555571471474
1008:Chr 19: 50.98 – 50.98 Mb
2799:10.1073/pnas.0707811104
1908:10.1074/jbc.M109.091850
1815:10.1091/mbc.e07-02-0124
1099:
1015:Chr 7: 43.46 – 43.47 Mb
654:epidermal lamellar body
3230:Proprotein convertases
2595:10.1073/pnas.242603899
2291:10.1038/sj.jid.5700284
2079:10.1074/jbc.M602372200
2039:10.1006/bbrc.1995.1853
2003:10.1074/jbc.m508017200
1157:intermediate filaments
3471:Eadie–Hofstee diagram
3404:Allosteric regulation
3080:Plasminogen activator
2748:10.1096/fj.06-6075com
2624:Clinical Biochemistry
2199:10.1007/s004030050393
1228:Clinical significance
695:epidermis development
208:Chromosome 19 (human)
3481:Lineweaver–Burk plot
3220:Prolyl endopeptidase
2430:Gynecologic Oncology
2355:10.1160/TH03-05-0261
1476:Biological Chemistry
1433:Biological Chemistry
1140:activators of KLK7.
649:extracellular region
503:skin of external ear
349:7 B3|7 28.27 cM
310:Chromosome 7 (mouse)
69:List of PDB id codes
42:Available structures
2790:2007PNAS..10416086D
2784:(41): 16086–16091.
2586:2002PNAS...9916899M
2580:(26): 16899–16903.
2072:(35): 25678–25688.
1955:(36): 21886–21890.
1901:(42): 32174–32181.
1488:10.1515/BC.2006.081
1445:10.1515/BC.2006.082
1395:(30): 19420–19426.
659:extracellular space
437:gingival epithelium
3440:Enzyme superfamily
3373:Enzyme promiscuity
2669:10.1101/gr.2596504
2663:(10B): 2121–2127.
2398:10.1002/cncr.22606
1247:Netherton syndrome
1122:stratum granulosum
825:ENSMUSG00000030713
673:Biological process
642:Cellular component
623:hydrolase activity
613:peptidase activity
606:Molecular function
535:Meckel's cartilage
3596:
3595:
3305:
3304:
3102:Complement system
2894:Digestive enzymes
2741:(12): 2068–2080.
1239:atopic dermatitis
1064:
1063:
1060:
1059:
1033:
1032:
998:
997:
977:
976:
939:
938:
918:
917:
880:
879:
861:
860:
831:
830:
812:
811:
786:
785:
767:
766:
715:
714:
664:secretory granule
590:
589:
586:
585:
555:
554:
542:
541:
480:
479:
469:mucosa of pharynx
378:
377:
277:
276:
104:
103:
100:
99:
52:Ortholog search:
3643:
3613:
3612:
3604:
3476:Hanes–Woolf plot
3419:Enzyme activator
3414:Enzyme inhibitor
3388:Enzyme catalysis
3332:
3325:
3318:
3309:
3308:
2867:
2860:
2853:
2844:
2843:
2821:
2811:
2801:
2768:
2750:
2725:
2715:
2690:
2680:
2647:
2617:
2607:
2597:
2564:
2525:
2524:
2507:(4): 1260–1266.
2495:
2489:
2488:
2460:
2454:
2453:
2424:
2418:
2417:
2392:(9): 1811–1820.
2381:
2375:
2374:
2337:
2331:
2330:
2321:(5): 1710–1720.
2310:
2304:
2303:
2293:
2284:(7): 1622–1632.
2269:
2263:
2262:
2225:
2219:
2218:
2182:
2176:
2175:
2165:
2141:
2135:
2134:
2098:
2092:
2091:
2081:
2057:
2051:
2050:
2022:
2016:
2015:
2005:
1996:(9): 5780–5789.
1981:
1975:
1974:
1964:
1940:
1931:
1930:
1920:
1910:
1886:
1880:
1879:
1854:(6): 1200–1203.
1843:
1837:
1836:
1826:
1809:(9): 3607–3619.
1794:
1788:
1787:
1777:
1745:
1739:
1738:
1728:
1719:(5): 1235–1244.
1704:
1695:
1694:
1684:
1660:
1651:
1650:
1640:
1608:
1602:
1601:
1584:(1–2): 119–128.
1572:
1566:
1565:
1555:
1531:
1525:
1524:
1517:
1508:
1507:
1471:
1465:
1464:
1430:
1421:
1415:
1414:
1404:
1380:
1374:
1373:
1362:
1356:
1355:
1344:
1338:
1328:
1317:
1307:
1153:corneodesmosomes
1046:
1045:
1017:
1010:
993:
981:
980:
972:
948:
947:
944:RefSeq (protein)
934:
922:
921:
913:
889:
888:
865:
864:
842:
841:
816:
815:
797:
796:
771:
770:
752:
751:
721:
720:
596:
595:
582:
573:
566:
565:
551:
491:
489:Top expressed in
484:
483:
429:
427:Top expressed in
422:
421:
401:
400:
384:
383:
374:
361:
350:
335:
328:
322:
311:
299:
283:
282:
273:
260:
249:
234:
227:
221:
210:
196:
180:
179:
174:
172:KLK7 - orthologs
125:
118:
95:
66:
65:
60:
39:
38:
33:
21:
20:
3651:
3650:
3646:
3645:
3644:
3642:
3641:
3640:
3621:
3620:
3619:
3607:
3599:
3597:
3592:
3504:Oxidoreductases
3490:
3466:Enzyme kinetics
3454:
3450:List of enzymes
3423:
3392:
3363:Catalytic triad
3341:
3336:
3306:
3301:
3203:
3180:
3146:
3096:
2933:
2902:Enteropeptidase
2888:
2871:
2829:
2824:
2657:Genome Research
2534:
2532:Further reading
2529:
2528:
2496:
2492:
2465:Human Pathology
2461:
2457:
2425:
2421:
2382:
2378:
2338:
2334:
2311:
2307:
2270:
2266:
2231:Nature Genetics
2226:
2222:
2183:
2179:
2142:
2138:
2099:
2095:
2058:
2054:
2023:
2019:
1982:
1978:
1941:
1934:
1887:
1883:
1844:
1840:
1795:
1791:
1760:(16): e159762.
1746:
1742:
1705:
1698:
1661:
1654:
1617:Nature Genetics
1609:
1605:
1573:
1569:
1532:
1528:
1519:
1518:
1511:
1473:
1472:
1468:
1428:
1422:
1418:
1381:
1377:
1364:
1363:
1359:
1346:
1345:
1341:
1329:
1320:
1308:
1299:
1294:
1255:
1235:
1230:
1161:stratum corneum
1114:
1102:
1075:serine protease
1055:View/Edit Mouse
1050:View/Edit Human
1013:
1006:
1003:Location (UCSC)
989:
968:
964:
960:
956:
930:
909:
905:
901:
897:
853:
806:ENSG00000169035
699:
668:
637:
578:
547:
538:
533:
529:
525:
521:
517:
513:
509:
505:
501:
487:
476:
471:
467:
463:
459:
457:skin of abdomen
455:
451:
447:
443:
439:
425:
369:
356:
348:
338:
337:
336:
329:
309:
286:Gene location (
268:
255:
247:
237:
236:
235:
228:
206:
183:Gene location (
134:
121:
114:
75:
53:
19:
12:
11:
5:
3649:
3639:
3638:
3633:
3618:
3617:
3594:
3593:
3591:
3590:
3577:
3564:
3551:
3538:
3525:
3512:
3498:
3496:
3492:
3491:
3489:
3488:
3483:
3478:
3473:
3468:
3462:
3460:
3456:
3455:
3453:
3452:
3447:
3442:
3437:
3431:
3429:
3428:Classification
3425:
3424:
3422:
3421:
3416:
3411:
3406:
3400:
3398:
3394:
3393:
3391:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3349:
3347:
3343:
3342:
3335:
3334:
3327:
3320:
3312:
3303:
3302:
3300:
3299:
3298:
3297:
3292:
3282:
3277:
3268:
3254:
3249:
3244:
3243:
3242:
3237:
3227:
3222:
3217:
3211:
3209:
3205:
3204:
3202:
3201:
3196:
3190:
3188:
3182:
3181:
3179:
3178:
3173:
3168:
3163:
3157:
3155:
3148:
3147:
3145:
3144:
3139:
3138:
3137:
3132:
3122:
3117:
3112:
3106:
3104:
3098:
3097:
3095:
3094:
3093:
3092:
3087:
3077:
3065:
3064:
3063:
3062:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2977:
2972:
2967:
2962:
2957:
2952:
2943:
2941:
2935:
2934:
2932:
2931:
2930:
2929:
2924:
2914:
2909:
2904:
2898:
2896:
2890:
2889:
2874:Endopeptidases
2870:
2869:
2862:
2855:
2847:
2841:
2840:
2828:
2827:External links
2825:
2823:
2822:
2769:
2726:
2706:(2): 360–366.
2691:
2648:
2630:(3): 230–237.
2618:
2565:
2547:(1): 119–130.
2535:
2533:
2530:
2527:
2526:
2490:
2471:(3): 409–418.
2455:
2436:(2): 283–288.
2419:
2376:
2349:(1): 180–186.
2332:
2305:
2264:
2243:10.1038/ng1493
2220:
2193:(4): 195–200.
2177:
2136:
2109:(6): 513–519.
2093:
2052:
2033:(2): 586–589.
2017:
1976:
1932:
1881:
1838:
1789:
1740:
1696:
1675:(1): 198–203.
1652:
1629:10.1038/ng.629
1623:(8): 676–683.
1603:
1567:
1546:(6): 471–474.
1526:
1509:
1466:
1439:(6): 637–641.
1416:
1375:
1357:
1339:
1318:
1296:
1295:
1293:
1290:
1254:
1251:
1234:
1231:
1229:
1226:
1174:Both KLK5 and
1149:corneodesmosin
1113:
1110:
1101:
1098:
1062:
1061:
1058:
1057:
1052:
1042:
1041:
1035:
1034:
1031:
1030:
1028:
1026:
1019:
1018:
1011:
1004:
1000:
999:
996:
995:
985:
984:
978:
975:
974:
952:
951:
945:
941:
940:
937:
936:
926:
925:
919:
916:
915:
893:
892:
886:
882:
881:
878:
877:
869:
868:
862:
859:
858:
846:
845:
839:
833:
832:
829:
828:
820:
819:
813:
810:
809:
801:
800:
794:
788:
787:
784:
783:
775:
774:
768:
765:
764:
756:
755:
749:
743:
742:
737:
732:
728:
727:
717:
716:
713:
712:
701:
700:
698:
697:
692:
687:
682:
676:
674:
670:
669:
667:
666:
661:
656:
651:
645:
643:
639:
638:
636:
635:
630:
625:
620:
615:
609:
607:
603:
602:
592:
591:
588:
587:
584:
583:
575:
574:
563:
557:
556:
553:
552:
544:
543:
540:
539:
537:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
493:
492:
481:
478:
477:
475:
474:
473:body of tongue
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
431:
430:
418:
417:
409:
398:
392:
391:
388:RNA expression
380:
379:
376:
375:
367:
363:
362:
354:
351:
346:
340:
339:
330:
323:
317:
313:
312:
307:
301:
300:
292:
291:
279:
278:
275:
274:
266:
262:
261:
253:
250:
245:
239:
238:
229:
222:
216:
212:
211:
204:
198:
197:
189:
188:
176:
175:
132:
128:
127:
119:
111:
110:
106:
105:
102:
101:
98:
97:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
9:
6:
4:
3:
2:
3648:
3637:
3634:
3632:
3629:
3628:
3626:
3616:
3611:
3606:
3605:
3602:
3588:
3584:
3583:
3578:
3575:
3571:
3570:
3565:
3562:
3558:
3557:
3552:
3549:
3545:
3544:
3539:
3536:
3532:
3531:
3526:
3523:
3519:
3518:
3513:
3510:
3506:
3505:
3500:
3499:
3497:
3493:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3463:
3461:
3457:
3451:
3448:
3446:
3445:Enzyme family
3443:
3441:
3438:
3436:
3433:
3432:
3430:
3426:
3420:
3417:
3415:
3412:
3410:
3409:Cooperativity
3407:
3405:
3402:
3401:
3399:
3395:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3368:Oxyanion hole
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3350:
3348:
3344:
3340:
3333:
3328:
3326:
3321:
3319:
3314:
3313:
3310:
3296:
3293:
3291:
3288:
3287:
3286:
3283:
3281:
3280:Streptokinase
3278:
3276:
3272:
3269:
3266:
3262:
3258:
3255:
3253:
3250:
3248:
3245:
3241:
3238:
3236:
3233:
3232:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3212:
3210:
3206:
3200:
3197:
3195:
3192:
3191:
3189:
3187:
3183:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3158:
3156:
3154:
3153:immune system
3149:
3143:
3142:C3-convertase
3140:
3136:
3133:
3131:
3128:
3127:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3107:
3105:
3103:
3099:
3091:
3088:
3086:
3083:
3082:
3081:
3078:
3076:
3073:
3071:
3067:
3066:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2982:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2945:
2944:
2942:
2940:
2936:
2928:
2925:
2923:
2920:
2919:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2899:
2897:
2895:
2891:
2886:
2883:
2879:
2875:
2868:
2863:
2861:
2856:
2854:
2849:
2848:
2845:
2839:
2835:
2831:
2830:
2819:
2815:
2810:
2805:
2800:
2795:
2791:
2787:
2783:
2779:
2775:
2770:
2766:
2762:
2758:
2754:
2749:
2744:
2740:
2736:
2735:FASEB Journal
2732:
2727:
2723:
2719:
2714:
2709:
2705:
2701:
2697:
2692:
2688:
2684:
2679:
2674:
2670:
2666:
2662:
2658:
2654:
2649:
2645:
2641:
2637:
2633:
2629:
2625:
2619:
2615:
2611:
2606:
2601:
2596:
2591:
2587:
2583:
2579:
2575:
2571:
2566:
2562:
2558:
2554:
2550:
2546:
2542:
2537:
2536:
2522:
2518:
2514:
2510:
2506:
2502:
2494:
2486:
2482:
2478:
2474:
2470:
2466:
2459:
2451:
2447:
2443:
2439:
2435:
2431:
2423:
2415:
2411:
2407:
2403:
2399:
2395:
2391:
2387:
2380:
2372:
2368:
2364:
2360:
2356:
2352:
2348:
2344:
2336:
2328:
2324:
2320:
2316:
2309:
2301:
2297:
2292:
2287:
2283:
2279:
2275:
2268:
2260:
2256:
2252:
2248:
2244:
2240:
2236:
2232:
2224:
2216:
2212:
2208:
2204:
2200:
2196:
2192:
2188:
2181:
2173:
2169:
2164:
2159:
2155:
2151:
2147:
2140:
2132:
2128:
2124:
2120:
2116:
2112:
2108:
2104:
2097:
2089:
2085:
2080:
2075:
2071:
2067:
2063:
2056:
2048:
2044:
2040:
2036:
2032:
2028:
2021:
2013:
2009:
2004:
1999:
1995:
1991:
1987:
1980:
1972:
1968:
1963:
1958:
1954:
1950:
1946:
1939:
1937:
1928:
1924:
1919:
1914:
1909:
1904:
1900:
1896:
1892:
1885:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1842:
1834:
1830:
1825:
1820:
1816:
1812:
1808:
1804:
1800:
1793:
1785:
1781:
1776:
1771:
1767:
1763:
1759:
1755:
1751:
1744:
1736:
1732:
1727:
1722:
1718:
1714:
1710:
1703:
1701:
1692:
1688:
1683:
1678:
1674:
1670:
1666:
1659:
1657:
1648:
1644:
1639:
1634:
1630:
1626:
1622:
1618:
1614:
1607:
1599:
1595:
1591:
1587:
1583:
1579:
1571:
1563:
1559:
1554:
1549:
1545:
1541:
1537:
1530:
1522:
1516:
1514:
1505:
1501:
1497:
1493:
1489:
1485:
1481:
1477:
1470:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1427:
1420:
1412:
1408:
1403:
1398:
1394:
1390:
1386:
1379:
1371:
1367:
1361:
1353:
1349:
1343:
1336:
1332:
1327:
1325:
1323:
1315:
1311:
1306:
1304:
1302:
1297:
1289:
1287:
1283:
1280:
1276:
1272:
1268:
1264:
1260:
1250:
1248:
1244:
1240:
1225:
1223:
1219:
1218:phenylalanine
1215:
1210:
1208:
1204:
1200:
1196:
1192:
1188:
1184:
1179:
1177:
1172:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1141:
1139:
1135:
1131:
1127:
1124:layer of the
1123:
1119:
1109:
1107:
1097:
1095:
1094:chromosome 19
1091:
1087:
1083:
1080:
1076:
1072:
1068:
1056:
1051:
1047:
1043:
1040:
1036:
1029:
1027:
1024:
1020:
1016:
1012:
1009:
1005:
1001:
994:
992:
986:
982:
979:
973:
971:
967:
963:
959:
953:
949:
946:
942:
935:
933:
927:
923:
920:
914:
912:
908:
904:
900:
894:
890:
887:
885:RefSeq (mRNA)
883:
876:
875:
870:
866:
863:
857:
856:
852:
847:
843:
840:
838:
834:
827:
826:
821:
817:
814:
808:
807:
802:
798:
795:
793:
789:
782:
781:
776:
772:
769:
763:
762:
757:
753:
750:
748:
744:
741:
738:
736:
733:
729:
726:
722:
718:
711:
707:
702:
696:
693:
691:
688:
686:
683:
681:
678:
677:
675:
672:
671:
665:
662:
660:
657:
655:
652:
650:
647:
646:
644:
641:
640:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
610:
608:
605:
604:
601:
600:Gene ontology
597:
593:
581:
576:
572:
567:
564:
562:
558:
550:
545:
534:
530:
526:
522:
519:sphenoid bone
518:
514:
510:
506:
502:
498:
497:
494:
490:
485:
482:
472:
468:
464:
460:
456:
453:skin of thigh
452:
448:
444:
440:
436:
435:
432:
428:
423:
420:
419:
416:
414:
410:
408:
407:
403:
402:
399:
397:
393:
389:
385:
381:
373:
368:
364:
360:
355:
345:
341:
334:
327:
321:
314:
306:
302:
298:
293:
289:
284:
280:
272:
267:
263:
259:
254:
244:
240:
233:
226:
220:
213:
209:
203:
199:
195:
190:
186:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
129:
124:
117:
112:
107:
96:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
3582:Translocases
3579:
3566:
3553:
3540:
3527:
3517:Transferases
3514:
3501:
3358:Binding site
3070:fibrinolysis
3068:
3019:
2946:
2912:Chymotrypsin
2781:
2777:
2738:
2734:
2703:
2699:
2660:
2656:
2627:
2623:
2577:
2573:
2544:
2540:
2504:
2500:
2493:
2468:
2464:
2458:
2433:
2429:
2422:
2389:
2385:
2379:
2346:
2342:
2335:
2318:
2314:
2308:
2281:
2277:
2267:
2237:(1): 56–65.
2234:
2230:
2223:
2190:
2186:
2180:
2156:(1): 62–66.
2153:
2149:
2139:
2106:
2102:
2096:
2069:
2065:
2055:
2030:
2026:
2020:
1993:
1989:
1979:
1952:
1948:
1898:
1894:
1884:
1851:
1847:
1841:
1806:
1802:
1792:
1757:
1753:
1743:
1716:
1712:
1672:
1668:
1620:
1616:
1606:
1581:
1577:
1570:
1543:
1539:
1529:
1479:
1475:
1469:
1436:
1432:
1419:
1392:
1388:
1378:
1369:
1360:
1351:
1342:
1256:
1236:
1233:Skin disease
1211:
1180:
1173:
1165:desquamation
1142:
1137:
1136:, which are
1115:
1105:
1103:
1078:
1070:
1066:
1065:
988:
962:NP_001230055
958:NP_001193982
955:
929:
907:NM_001243126
903:NM_001207053
896:
872:
849:
823:
804:
778:
759:
739:
734:
531:basisphenoid
511:skin of back
411:
404:
131:External IDs
74:
15:
3353:Active site
2975:Factor XIIa
2955:Factor VIIa
2939:Coagulation
1754:JCI Insight
1286:lung cancer
1169:homeostasis
1145:desmocollin
690:proteolysis
465:skin of hip
449:skin of arm
445:human penis
370:43,465,783
357:43,460,718
269:50,984,099
256:50,976,468
109:Identifiers
3625:Categories
3556:Isomerases
3530:Hydrolases
3397:Regulation
3257:Subtilisin
3199:Batroxobin
2980:Kallikrein
2970:Factor XIa
2960:Factor IXa
2927:Pancreatic
2922:Neutrophil
1337:, May 2017
1316:, May 2017
1292:References
1271:pancreatic
1259:metastasis
1185:including
1183:inhibitors
1134:matriptase
1090:kallikrein
527:belly cord
415:(ortholog)
152:HomoloGene
3636:EC 3.4.21
3435:EC number
3285:Cathepsin
3271:Sedolisin
3247:Prostasin
2965:Factor Xa
1243:psoriasis
1126:epidermis
1096:(19q13).
1086:epidermis
991:NP_036002
970:NP_644806
966:NP_005037
932:NM_011872
911:NM_005046
899:NM_139277
725:Orthologs
515:esophagus
160:GeneCards
3459:Kinetics
3383:Cofactor
3346:Activity
3186:Venombin
3171:Tryptase
3166:Granzyme
3120:Factor I
3115:Factor D
3110:Factor B
2950:Thrombin
2947:factors:
2917:Elastase
2818:17909180
2765:18170331
2757:17012259
2722:15675955
2687:15489334
2644:14972646
2614:12477932
2561:11054574
2521:15766562
2485:21193224
2450:15297163
2406:17354228
2363:14691584
2327:12738725
2300:16628198
2259:11404025
2251:15619623
2215:37395502
2207:10335915
2172:15191543
2123:17518992
2088:16740631
2012:16298998
1927:20667819
1876:42775195
1868:16307658
1833:17596512
1784:35900871
1735:15140227
1691:15654974
1647:20657595
1598:10974542
1504:83910246
1496:16800723
1453:16800724
1333:–
1312:–
1279:melanoma
1214:tyrosine
1138:in vitro
1112:Function
1039:Wikidata
704:Sources:
248:19q13.41
3615:Biology
3569:Ligases
3339:Enzymes
3225:Pronase
3215:Acrosin
3161:Chymase
3075:Plasmin
2907:Trypsin
2838:S01.017
2809:2042166
2786:Bibcode
2582:Bibcode
2414:8142528
2371:5692357
2047:7794273
1971:8702990
1918:2952218
1824:1951746
1775:9462509
1638:3081165
1562:1685827
1411:8034709
1335:Ensembl
1314:Ensembl
1282:cancers
1263:ovarian
1222:leucine
1201:. Both
1120:in the
1118:zymogen
1073:) is a
837:UniProt
792:Ensembl
731:Species
710:QuickGO
523:decidua
390:pattern
148:1346336
116:Aliases
3601:Portal
3543:Lyases
3252:Reelin
3194:Ancrod
3151:Other
2885:3.4.21
2834:MEROPS
2816:
2806:
2763:
2755:
2720:
2685:
2678:528928
2675:
2642:
2612:
2605:139241
2602:
2559:
2519:
2483:
2448:
2412:
2404:
2386:Cancer
2369:
2361:
2325:
2298:
2257:
2249:
2213:
2205:
2170:
2131:866377
2129:
2121:
2086:
2045:
2010:
1969:
1925:
1915:
1874:
1866:
1831:
1821:
1782:
1772:
1733:
1689:
1645:
1635:
1596:
1560:
1502:
1494:
1461:436200
1459:
1451:
1409:
1277:, and
1275:cervix
1267:breast
1253:Cancer
1195:elafin
1191:SPINK6
1025:search
1023:PubMed
874:Q91VE3
855:Q6DTY1
851:P49862
747:Entrez
561:BioGPS
461:nipple
140:604438
3495:Types
3261:Furin
3208:Other
3135:MASP2
3130:MASP1
3060:KLK15
3055:KLK14
3050:KLK13
3045:KLK12
3040:KLK11
3035:KLK10
2761:S2CID
2410:S2CID
2367:S2CID
2255:S2CID
2211:S2CID
2127:S2CID
1872:S2CID
1500:S2CID
1457:S2CID
1429:(PDF)
1187:LEKTI
1176:KLK14
780:23993
740:Mouse
735:Human
706:Amigo
441:vulva
413:Mouse
406:Human
353:Start
288:Mouse
252:Start
185:Human
156:37998
3587:list
3580:EC7
3574:list
3567:EC6
3561:list
3554:EC5
3548:list
3541:EC4
3535:list
3528:EC3
3522:list
3515:EC2
3509:list
3502:EC1
3275:TPP1
3125:MASP
3030:KLK9
3025:KLK8
3020:KLK7
3015:KLK6
3010:KLK5
3005:KLK4
3000:KLK3
2995:KLK2
2990:KLK1
2832:The
2814:PMID
2753:PMID
2718:PMID
2683:PMID
2640:PMID
2610:PMID
2557:PMID
2541:Gene
2517:PMID
2481:PMID
2446:PMID
2402:PMID
2359:PMID
2323:PMID
2296:PMID
2247:PMID
2203:PMID
2168:PMID
2119:PMID
2084:PMID
2043:PMID
2008:PMID
1967:PMID
1923:PMID
1864:PMID
1829:PMID
1780:PMID
1731:PMID
1687:PMID
1643:PMID
1594:PMID
1578:Gene
1558:PMID
1492:PMID
1449:PMID
1407:PMID
1245:and
1205:and
1197:and
1147:and
1130:KLK5
1106:KLK7
1100:Gene
1082:gene
1079:KLK7
1071:KLK7
761:5650
396:Bgee
344:Band
305:Chr.
243:Band
202:Chr.
164:KLK7
136:OMIM
123:KLK7
93:3BSQ
89:2QXJ
85:2QXI
81:2QXH
77:2QXG
58:RCSB
55:PDBe
24:KLK7
3265:S1P
2985:PSA
2804:PMC
2794:doi
2782:104
2743:doi
2708:doi
2704:124
2673:PMC
2665:doi
2632:doi
2600:PMC
2590:doi
2549:doi
2545:257
2509:doi
2505:329
2473:doi
2438:doi
2394:doi
2390:109
2351:doi
2286:doi
2282:126
2239:doi
2195:doi
2191:291
2158:doi
2154:123
2111:doi
2074:doi
2070:281
2035:doi
2031:211
1998:doi
1994:281
1957:doi
1953:271
1913:PMC
1903:doi
1899:285
1856:doi
1852:153
1819:PMC
1811:doi
1770:PMC
1762:doi
1721:doi
1717:122
1677:doi
1673:124
1633:PMC
1625:doi
1586:doi
1582:254
1548:doi
1484:doi
1480:387
1441:doi
1437:387
1397:doi
1393:269
1261:in
1220:or
1132:or
499:lip
366:End
265:End
168:OMA
144:MGI
48:PDB
3627::
2882:EC
2876::
2812:.
2802:.
2792:.
2780:.
2776:.
2759:.
2751:.
2739:20
2737:.
2733:.
2716:.
2702:.
2698:.
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1207:Cu
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