255:
232:
154:
129:
261:
160:
2927:
1078:
Evidence suggests a role for NCEH in cancer. Cancer cell lines contain unusually high levels of the protein. Reduction of the amount of NCEH1 in cancer cells reduces tumor migration and growth in mice and addition of alkyl-LPA restores these processes.
1290:
Buchebner M, Pfeifer T, Rathke N, Chandak PG, Lass A, Schreiber R, Kratzer A, Zimmermann R, Sattler W, Koefeler H, Fröhlich E, Kostner GM, Birner-Gruenberger R, Chiang KP, Haemmerle G, Zechner R, Levak-Frank S, Cravatt B, Kratky D (Oct 2010).
1750:
Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S (Nov 2010).
1342:
Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S (Nov 2010).
268:
167:
1669:
Okazaki H, Igarashi M, Nishi M, Sekiya M, Tajima M, Takase S, Takanashi M, Ohta K, Tamura Y, Okazaki S, Yahagi N, Ohashi K, Amemiya-Kudo M, Nakagawa Y, Nagai R, Kadowaki T, Osuga J, Ishibashi S (Nov 2008).
1543:
Okazaki H, Igarashi M, Nishi M, Sekiya M, Tajima M, Takase S, Takanashi M, Ohta K, Tamura Y, Okazaki S, Yahagi N, Ohashi K, Amemiya-Kudo M, Nakagawa Y, Nagai R, Kadowaki T, Osuga J, Ishibashi S (Nov 2008).
1098:
that contains an N-terminal transmembrane domain, a central catalytic domain and a lipid-binding domain at its C-terminus. The protein exists in three isoforms that result from differences in
2408:
2354:
715:
696:
90:
2016:
1209:
2177:
1191:
1834:
2273:
939:
1984:
946:
1715:
Yilmaz S, Boffito M, Collot-Teixeira S, De
Lorenzo F, Waters L, Fletcher C, Back D, Pozniak A, Gazzard B, McGregor JL (Jul 2010).
2001:
1717:"Investigation of low-dose ritonavir on human peripheral blood mononuclear cells using gene expression whole genome microarrays"
2248:
1174:
2947:
2162:
1070:. However, loss of the protein in mice selectively reduces 2-acetyl monoalkylglycerol ether activity throughout the body.
2263:
2257:
2058:
1808:
1227:
1153:
2106:
1293:"Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363"
2646:
2217:
2006:
254:
2324:
2212:
1178:
1157:
231:
2133:
2043:
1996:
760:
2802:
2555:
2496:
1130:
741:
2600:
2167:
2157:
1672:"Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages"
1636:"An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling"
1546:"Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages"
1248:"An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling"
153:
128:
70:
1753:"The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages"
1345:"The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages"
2560:
2452:
2077:
267:
166:
2917:
2146:
2142:
2138:
2054:
1887:
1032:
260:
159:
2903:
2890:
2877:
2864:
2851:
2838:
2825:
2787:
2314:
1870:
1386:"Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness"
1125:
57:
2797:
2751:
2694:
2062:
1911:
1825:
897:
893:
889:
842:
838:
834:
78:
17:
1036:
2699:
1931:
1801:
1060:
922:
901:
863:
830:
2487:
2126:
2720:
2639:
2422:
2319:
2111:
2072:
1936:
1858:
1056:
1024:
2792:
2605:
2440:
2435:
2368:
2028:
1853:
1456:
1397:
142:
98:
8:
2756:
2460:
2430:
2234:
2229:
2153:
2089:
1875:
1460:
1401:
2689:
2593:
2445:
1926:
1916:
1794:
1698:
1671:
1572:
1545:
1479:
1444:
1319:
1292:
102:
1420:
1385:
630:
625:
620:
615:
610:
605:
589:
584:
579:
574:
569:
553:
548:
543:
538:
2952:
2394:
2339:
2307:
2182:
1901:
1774:
1738:
1703:
1657:
1622:
1577:
1525:
1484:
1425:
1366:
1324:
1269:
1120:
1067:
50:
82:
2735:
2730:
2704:
2632:
2470:
2050:
1955:
1950:
1906:
1764:
1728:
1693:
1683:
1652:
1647:
1635:
1617:
1612:
1600:
1567:
1557:
1515:
1474:
1464:
1415:
1405:
1356:
1314:
1304:
1264:
1259:
1247:
1095:
1066:
Controversial studies by one group also implicate the protein in the hydrolysis of
347:
278:
222:
177:
1769:
1752:
1361:
1344:
1055:
Monoalkylglycerol ethers (MAGEs) can then be converted to lysophospholipids alkyl-
2782:
2766:
2679:
2572:
2386:
2302:
2297:
2292:
2205:
2200:
1960:
1838:
322:
106:
1786:
1733:
1716:
1214:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1196:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2931:
2820:
2761:
2545:
2540:
2535:
1921:
1896:
1892:
1865:
1848:
1449:
Proceedings of the
National Academy of Sciences of the United States of America
1390:
Proceedings of the
National Academy of Sciences of the United States of America
423:
1504:"Each lipase has a unique sensitivity profile for organophosphorus inhibitors"
2941:
2725:
2684:
2286:
2195:
1945:
1443:
Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE (Apr 2005).
1099:
525:
1520:
1503:
1469:
1102:. Transcripts encode a protein for isoform a of 448, b of 440 and c of 275
1086:
oxon. Conversely, enzymatic activity can be inhibited by organophosphates.
483:
361:
2674:
2413:
2344:
2067:
1988:
1778:
1742:
1707:
1688:
1661:
1626:
1581:
1562:
1529:
1488:
1429:
1410:
1370:
1328:
1273:
1083:
340:
119:
986:
981:
2898:
2833:
2669:
2588:
2359:
2253:
2116:
2082:
2020:
1103:
1028:
805:
786:
1309:
2565:
239:
136:
86:
1714:
2872:
2846:
2478:
2277:
2190:
1817:
1115:
660:
306:
293:
205:
192:
94:
2926:
2523:
2518:
2513:
2334:
1969:
1821:
1082:
NCEH can break down organophosphates like the pesticide metabolite
970:
1502:
Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE (May 2006).
2530:
2508:
2503:
2121:
772:
727:
645:
641:
74:
2885:
2655:
2550:
2483:
2376:
1974:
1882:
1633:
1445:"A brain detoxifying enzyme for organophosphorus nerve poisons"
1245:
1010:
954:
682:
2859:
2492:
2243:
2239:
1289:
1634:
Chiang KP, Niessen S, Saghatelian A, Cravatt BF (Oct 2006).
1246:
Chiang KP, Niessen S, Saghatelian A, Cravatt BF (Oct 2006).
2224:
2101:
2094:
2038:
2033:
1031:, as part of an enzymatic pathway regulating the levels of
1017:
2624:
1668:
1542:
1051:
2-acetyl monoalkylglycerol ether → monoalkylglycerol ether
1749:
1383:
1341:
1501:
1442:
330:
61:, AADACL1, NCEH, neutral cholesterol ester hydrolase 1
2915:
1384:
Jessani N, Liu Y, Humphrey M, Cravatt BF (Aug 2002).
495:
1228:"Entrez Gene: Neutral cholesterol ester hydrolase 1"
1170:
1168:
1166:
1149:
1147:
1145:
2112:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
1816:
277:
176:
2939:
1598:
1280:
1234:
1163:
1142:
27:Protein-coding gene in the species Homo sapiens
1335:
1285:
1283:
1241:
1239:
1237:
1175:GRCm38: Ensembl release 89: ENSMUSG00000027698
2640:
1802:
1047:The enzymatic reaction catalyzed by NCEH is:
1536:
1039:that may be involved in cancer development.
1154:GRCh38: Ensembl release 89: ENSG00000144959
2647:
2633:
1809:
1795:
631:low-density lipoprotein particle clearance
1768:
1732:
1697:
1687:
1651:
1616:
1571:
1561:
1519:
1478:
1468:
1419:
1409:
1360:
1318:
1308:
1263:
1073:
580:intracellular membrane-bounded organelle
2002:Ubiquitin carboxy-terminal hydrolase L1
1601:"Enzyme annotation with chemical tools"
14:
2940:
2628:
2582:either deoxy- or ribo-
1790:
1220:
999:Neutral cholesterol ester hydrolase 1
282:
243:
238:
181:
140:
135:
2163:Protein serine/threonine phosphatase
1599:Herman AG, Stockwell BR (Oct 2006).
2264:Cyclic nucleotide phosphodiesterase
2258:Clostridium perfringens alpha toxin
2059:Tartrate-resistant acid phosphatase
1676:The Journal of Biological Chemistry
1550:The Journal of Biological Chemistry
539:carboxylic ester hydrolase activity
24:
2107:Pyruvate dehydrogenase phosphatase
1591:
25:
2964:
2007:4-hydroxybenzoyl-CoA thioesterase
1023:NCEH is an enzyme located in the
1013:that in humans is encoded by the
372:lateral nuclear group of thalamus
2925:
1029:2-acetyl monoalkylglycerol ether
1003:arylacetamide deacetylase-like 1
266:
259:
253:
230:
165:
158:
152:
127:
2325:N-acetylglucosamine-6-sulfatase
2213:Sphingomyelin phosphodiesterase
1495:
1436:
2134:Inositol-phosphate phosphatase
1997:Palmitoyl protein thioesterase
1653:10.1016/j.chembiol.2006.08.008
1618:10.1016/j.chembiol.2006.10.002
1377:
1265:10.1016/j.chembiol.2006.08.008
1202:
1184:
585:endoplasmic reticulum membrane
570:integral component of membrane
484:More reference expression data
13:
1:
2497:RNA-induced silencing complex
1770:10.1161/CIRCRESAHA.110.226613
1362:10.1161/CIRCRESAHA.110.226613
1136:
251:
150:
2601:Serratia marcescens nuclease
2168:Dual-specificity phosphatase
2158:Protein tyrosine phosphatase
1089:
626:xenobiotic metabolic process
7:
2948:Genes on human chromosome 3
2654:
2078:Fructose 1,6-bisphosphatase
1734:10.1016/j.ygeno.2010.03.011
1109:
1042:
10:
2969:
1033:platelet activating factor
2811:
2803:Michaelis–Menten kinetics
2775:
2744:
2713:
2662:
2581:
2469:
2421:
2407:
2385:
2367:
2353:
2333:
2315:Galactosamine-6 sulfatase
2272:
2176:
2015:
1983:
1871:6-phosphogluconolactonase
1833:
1297:Journal of Lipid Research
1210:"Mouse PubMed Reference:"
1192:"Human PubMed Reference:"
1126:Lysophospholipid receptor
985:
980:
976:
969:
953:
940:Chr 3: 172.63 – 172.71 Mb
934:
919:
915:
886:
882:
875:
860:
856:
827:
823:
816:
803:
799:
784:
780:
771:
758:
754:
739:
735:
726:
713:
709:
694:
690:
681:
666:
659:
655:
639:
554:serine hydrolase activity
524:
520:
508:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
2695:Diffusion-limited enzyme
2063:Purple acid phosphatases
549:sterol esterase activity
1640:Chemistry & Biology
1605:Chemistry & Biology
1470:10.1073/pnas.0501915102
1252:Chemistry & Biology
1061:lysophosphatidylcholine
947:Chr 3: 27.24 – 27.34 Mb
606:lipid catabolic process
450:myocardium of ventricle
434:interventricular septum
2488:Microprocessor complex
2127:Beta-propeller phytase
1689:10.1074/jbc.M802686200
1563:10.1074/jbc.M802686200
1508:Toxicological Sciences
1411:10.1073/pnas.162187599
1059:(alkyl-LPA) and alkyl-
392:superior frontal gyrus
2788:Eadie–Hofstee diagram
2721:Allosteric regulation
2423:Endodeoxyribonuclease
2320:Iduronate-2-sulfatase
2073:Glucose 6-phosphatase
1859:Butyrylcholinesterase
1521:10.1093/toxsci/kfj124
1074:Clinical significance
1057:lysophosphatidic acid
1025:endoplasmic reticulum
1001:(NCEH) also known as
575:endoplasmic reticulum
458:epithelium of stomach
404:primary visual cortex
2798:Lineweaver–Burk plot
2606:Micrococcal nuclease
2441:Deoxyribonuclease IV
2436:Deoxyribonuclease II
2369:Exodeoxyribonuclease
2029:Alkaline phosphatase
1854:Acetylcholinesterase
1757:Circulation Research
1349:Circulation Research
245:Chromosome 3 (mouse)
143:Chromosome 3 (human)
2461:UvrABC endonuclease
2431:Deoxyribonuclease I
2154:Protein phosphatase
2090:Protein phosphatase
1888:Bile salt-dependent
1876:PAF acetylhydrolase
1682:(48): 33357–33364.
1461:2005PNAS..102.6195N
1402:2002PNAS...9910335J
1310:10.1194/jlr.M004259
1027:. NCEH hydrolyzes
380:islet of Langerhans
2757:Enzyme superfamily
2690:Enzyme promiscuity
2594:Mung bean nuclease
2453:Restriction enzyme
2446:Restriction enzyme
1068:cholesterol esters
761:ENSMUSG00000027698
599:Biological process
563:Cellular component
544:hydrolase activity
532:Molecular function
2913:
2912:
2622:
2621:
2618:
2617:
2614:
2613:
2403:
2402:
2395:Oligonucleotidase
2340:deoxyribonuclease
2308:Steroid sulfatase
2183:Phosphodiesterase
1912:Hormone-sensitive
1763:(11): 1387–1395.
1646:(10): 1041–1050.
1611:(10): 1013–1014.
1121:phosphatidic acid
1037:lysophospholipids
996:
995:
992:
991:
965:
964:
930:
929:
909:
908:
871:
870:
850:
849:
812:
811:
793:
792:
767:
766:
748:
747:
722:
721:
703:
702:
651:
650:
621:catabolic process
516:
515:
512:
511:
490:
489:
477:
476:
415:
414:
400:postcentral gyrus
384:prefrontal cortex
313:
312:
212:
211:
107:NCEH1 - orthologs
16:(Redirected from
2960:
2930:
2929:
2921:
2793:Hanes–Woolf plot
2736:Enzyme activator
2731:Enzyme inhibitor
2705:Enzyme catalysis
2649:
2642:
2635:
2626:
2625:
2471:Endoribonuclease
2457:
2451:
2419:
2418:
2365:
2364:
2351:
2350:
2051:Acid phosphatase
1932:Monoacylglycerol
1842:ester hydrolases
1811:
1804:
1797:
1788:
1787:
1782:
1772:
1746:
1736:
1711:
1701:
1691:
1665:
1655:
1630:
1620:
1586:
1585:
1575:
1565:
1556:(48): 33357–64.
1540:
1534:
1533:
1523:
1499:
1493:
1492:
1482:
1472:
1455:(17): 6195–200.
1440:
1434:
1433:
1423:
1413:
1396:(16): 10335–40.
1381:
1375:
1374:
1364:
1339:
1333:
1332:
1322:
1312:
1303:(10): 2896–908.
1287:
1278:
1277:
1267:
1243:
1232:
1231:
1224:
1218:
1217:
1206:
1200:
1199:
1188:
1182:
1172:
1161:
1151:
1096:serine hydrolase
978:
977:
949:
942:
925:
913:
912:
904:
880:
879:
876:RefSeq (protein)
866:
854:
853:
845:
821:
820:
797:
796:
778:
777:
752:
751:
733:
732:
707:
706:
688:
687:
657:
656:
616:lipid metabolism
522:
521:
501:
500:
486:
438:secondary oocyte
426:
424:Top expressed in
419:
418:
376:secondary oocyte
364:
362:Top expressed in
357:
356:
336:
335:
319:
318:
309:
296:
285:
270:
263:
257:
246:
234:
218:
217:
208:
195:
184:
169:
162:
156:
145:
131:
115:
114:
109:
60:
53:
32:
31:
21:
2968:
2967:
2963:
2962:
2961:
2959:
2958:
2957:
2938:
2937:
2936:
2924:
2916:
2914:
2909:
2821:Oxidoreductases
2807:
2783:Enzyme kinetics
2771:
2767:List of enzymes
2740:
2709:
2680:Catalytic triad
2658:
2653:
2623:
2610:
2577:
2465:
2455:
2449:
2412:
2399:
2387:Exoribonuclease
2381:
2358:
2342:
2338:
2329:
2303:Arylsulfatase L
2298:Arylsulfatase B
2293:Arylsulfatase A
2268:
2181:
2172:
2011:
1979:
1841:
1829:
1815:
1785:
1594:
1592:Further reading
1589:
1541:
1537:
1500:
1496:
1441:
1437:
1382:
1378:
1355:(11): 1387–95.
1340:
1336:
1288:
1281:
1258:(10): 1041–50.
1244:
1235:
1226:
1225:
1221:
1208:
1207:
1203:
1190:
1189:
1185:
1173:
1164:
1152:
1143:
1139:
1112:
1092:
1076:
1045:
987:View/Edit Mouse
982:View/Edit Human
945:
938:
935:Location (UCSC)
921:
900:
896:
892:
888:
862:
841:
837:
833:
829:
742:ENSG00000144959
635:
594:
558:
482:
473:
470:proximal tubule
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
411:
408:caudate nucleus
406:
402:
398:
396:right ventricle
394:
390:
388:Brodmann area 9
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
2966:
2956:
2955:
2950:
2935:
2934:
2911:
2910:
2908:
2907:
2894:
2881:
2868:
2855:
2842:
2829:
2815:
2813:
2809:
2808:
2806:
2805:
2800:
2795:
2790:
2785:
2779:
2777:
2773:
2772:
2770:
2769:
2764:
2759:
2754:
2748:
2746:
2745:Classification
2742:
2741:
2739:
2738:
2733:
2728:
2723:
2717:
2715:
2711:
2710:
2708:
2707:
2702:
2697:
2692:
2687:
2682:
2677:
2672:
2666:
2664:
2660:
2659:
2652:
2651:
2644:
2637:
2629:
2620:
2619:
2616:
2615:
2612:
2611:
2609:
2608:
2603:
2598:
2597:
2596:
2585:
2583:
2579:
2578:
2576:
2575:
2570:
2569:
2568:
2563:
2558:
2553:
2543:
2538:
2533:
2528:
2527:
2526:
2521:
2516:
2511:
2501:
2500:
2499:
2490:
2475:
2473:
2467:
2466:
2464:
2463:
2458:
2443:
2438:
2433:
2427:
2425:
2416:
2405:
2404:
2401:
2400:
2398:
2397:
2391:
2389:
2383:
2382:
2380:
2379:
2373:
2371:
2362:
2348:
2331:
2330:
2328:
2327:
2322:
2317:
2312:
2311:
2310:
2305:
2300:
2295:
2282:
2280:
2270:
2269:
2267:
2266:
2261:
2251:
2246:
2237:
2232:
2227:
2222:
2221:
2220:
2210:
2209:
2208:
2203:
2193:
2187:
2185:
2174:
2173:
2171:
2170:
2165:
2160:
2151:
2150:
2149:
2131:
2130:
2129:
2119:
2114:
2109:
2104:
2099:
2098:
2097:
2087:
2086:
2085:
2075:
2070:
2065:
2048:
2047:
2046:
2041:
2036:
2025:
2023:
2013:
2012:
2010:
2009:
2004:
1999:
1993:
1991:
1981:
1980:
1978:
1977:
1972:
1966:
1965:
1964:
1963:
1958:
1953:
1942:
1941:
1940:
1939:
1937:Diacylglycerol
1934:
1929:
1924:
1919:
1914:
1909:
1904:
1899:
1890:
1879:
1878:
1873:
1868:
1866:Pectinesterase
1863:
1862:
1861:
1856:
1849:Cholinesterase
1845:
1843:
1831:
1830:
1814:
1813:
1806:
1799:
1791:
1784:
1783:
1747:
1712:
1666:
1631:
1595:
1593:
1590:
1588:
1587:
1535:
1494:
1435:
1376:
1334:
1279:
1233:
1219:
1201:
1183:
1162:
1140:
1138:
1135:
1134:
1133:
1128:
1123:
1118:
1111:
1108:
1091:
1088:
1075:
1072:
1053:
1052:
1044:
1041:
994:
993:
990:
989:
984:
974:
973:
967:
966:
963:
962:
960:
958:
951:
950:
943:
936:
932:
931:
928:
927:
917:
916:
910:
907:
906:
884:
883:
877:
873:
872:
869:
868:
858:
857:
851:
848:
847:
825:
824:
818:
814:
813:
810:
809:
801:
800:
794:
791:
790:
782:
781:
775:
769:
768:
765:
764:
756:
755:
749:
746:
745:
737:
736:
730:
724:
723:
720:
719:
711:
710:
704:
701:
700:
692:
691:
685:
679:
678:
673:
668:
664:
663:
653:
652:
649:
648:
637:
636:
634:
633:
628:
623:
618:
613:
608:
602:
600:
596:
595:
593:
592:
587:
582:
577:
572:
566:
564:
560:
559:
557:
556:
551:
546:
541:
535:
533:
529:
528:
518:
517:
514:
513:
510:
509:
506:
505:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
442:primary oocyte
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
9:
6:
4:
3:
2:
2965:
2954:
2951:
2949:
2946:
2945:
2943:
2933:
2928:
2923:
2922:
2919:
2905:
2901:
2900:
2895:
2892:
2888:
2887:
2882:
2879:
2875:
2874:
2869:
2866:
2862:
2861:
2856:
2853:
2849:
2848:
2843:
2840:
2836:
2835:
2830:
2827:
2823:
2822:
2817:
2816:
2814:
2810:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2780:
2778:
2774:
2768:
2765:
2763:
2762:Enzyme family
2760:
2758:
2755:
2753:
2750:
2749:
2747:
2743:
2737:
2734:
2732:
2729:
2727:
2726:Cooperativity
2724:
2722:
2719:
2718:
2716:
2712:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2685:Oxyanion hole
2683:
2681:
2678:
2676:
2673:
2671:
2668:
2667:
2665:
2661:
2657:
2650:
2645:
2643:
2638:
2636:
2631:
2630:
2627:
2607:
2604:
2602:
2599:
2595:
2592:
2591:
2590:
2587:
2586:
2584:
2580:
2574:
2571:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2548:
2547:
2544:
2542:
2539:
2537:
2534:
2532:
2529:
2525:
2522:
2520:
2517:
2515:
2512:
2510:
2507:
2506:
2505:
2502:
2498:
2494:
2491:
2489:
2485:
2482:
2481:
2480:
2477:
2476:
2474:
2472:
2468:
2462:
2459:
2454:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2428:
2426:
2424:
2420:
2417:
2415:
2410:
2406:
2396:
2393:
2392:
2390:
2388:
2384:
2378:
2375:
2374:
2372:
2370:
2366:
2363:
2361:
2356:
2352:
2349:
2346:
2341:
2336:
2332:
2326:
2323:
2321:
2318:
2316:
2313:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2290:
2289:
2288:
2287:arylsulfatase
2284:
2283:
2281:
2279:
2275:
2271:
2265:
2262:
2259:
2255:
2252:
2250:
2247:
2245:
2241:
2238:
2236:
2233:
2231:
2228:
2226:
2223:
2219:
2216:
2215:
2214:
2211:
2207:
2204:
2202:
2199:
2198:
2197:
2196:Phospholipase
2194:
2192:
2189:
2188:
2186:
2184:
2179:
2175:
2169:
2166:
2164:
2161:
2159:
2155:
2152:
2148:
2144:
2140:
2137:
2136:
2135:
2132:
2128:
2125:
2124:
2123:
2120:
2118:
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2096:
2093:
2092:
2091:
2088:
2084:
2081:
2080:
2079:
2076:
2074:
2071:
2069:
2066:
2064:
2060:
2056:
2052:
2049:
2045:
2042:
2040:
2037:
2035:
2032:
2031:
2030:
2027:
2026:
2024:
2022:
2018:
2014:
2008:
2005:
2003:
2000:
1998:
1995:
1994:
1992:
1990:
1986:
1982:
1976:
1973:
1971:
1968:
1967:
1962:
1959:
1957:
1954:
1952:
1949:
1948:
1947:
1946:Phospholipase
1944:
1943:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1898:
1894:
1891:
1889:
1886:
1885:
1884:
1881:
1880:
1877:
1874:
1872:
1869:
1867:
1864:
1860:
1857:
1855:
1852:
1851:
1850:
1847:
1846:
1844:
1840:
1836:
1832:
1827:
1823:
1819:
1812:
1807:
1805:
1800:
1798:
1793:
1792:
1789:
1780:
1776:
1771:
1766:
1762:
1758:
1754:
1748:
1744:
1740:
1735:
1730:
1726:
1722:
1718:
1713:
1709:
1705:
1700:
1695:
1690:
1685:
1681:
1677:
1673:
1667:
1663:
1659:
1654:
1649:
1645:
1641:
1637:
1632:
1628:
1624:
1619:
1614:
1610:
1606:
1602:
1597:
1596:
1583:
1579:
1574:
1569:
1564:
1559:
1555:
1551:
1547:
1539:
1531:
1527:
1522:
1517:
1514:(1): 166–72.
1513:
1509:
1505:
1498:
1490:
1486:
1481:
1476:
1471:
1466:
1462:
1458:
1454:
1450:
1446:
1439:
1431:
1427:
1422:
1417:
1412:
1407:
1403:
1399:
1395:
1391:
1387:
1380:
1372:
1368:
1363:
1358:
1354:
1350:
1346:
1338:
1330:
1326:
1321:
1316:
1311:
1306:
1302:
1298:
1294:
1286:
1284:
1275:
1271:
1266:
1261:
1257:
1253:
1249:
1242:
1240:
1238:
1229:
1223:
1215:
1211:
1205:
1197:
1193:
1187:
1180:
1176:
1171:
1169:
1167:
1159:
1155:
1150:
1148:
1146:
1141:
1132:
1131:LPA signaling
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1113:
1107:
1105:
1101:
1100:mRNA splicing
1097:
1087:
1085:
1080:
1071:
1069:
1064:
1063:(alkyl-LPC).
1062:
1058:
1050:
1049:
1048:
1040:
1038:
1034:
1030:
1026:
1021:
1019:
1016:
1012:
1008:
1005:(AADACL1) or
1004:
1000:
988:
983:
979:
975:
972:
968:
961:
959:
956:
952:
948:
944:
941:
937:
933:
926:
924:
918:
914:
911:
905:
903:
899:
895:
891:
885:
881:
878:
874:
867:
865:
859:
855:
852:
846:
844:
840:
836:
832:
826:
822:
819:
817:RefSeq (mRNA)
815:
808:
807:
802:
798:
795:
789:
788:
783:
779:
776:
774:
770:
763:
762:
757:
753:
750:
744:
743:
738:
734:
731:
729:
725:
718:
717:
712:
708:
705:
699:
698:
693:
689:
686:
684:
680:
677:
674:
672:
669:
665:
662:
658:
654:
647:
643:
638:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
603:
601:
598:
597:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
567:
565:
562:
561:
555:
552:
550:
547:
545:
542:
540:
537:
536:
534:
531:
530:
527:
526:Gene ontology
523:
519:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
446:otolith organ
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
2899:Translocases
2896:
2883:
2870:
2857:
2844:
2834:Transferases
2831:
2818:
2675:Binding site
2456:}}
2450:{{
2414:Endonuclease
2345:ribonuclease
2285:
2068:Nucleotidase
1989:Thioesterase
1760:
1756:
1727:(1): 57–65.
1724:
1720:
1679:
1675:
1643:
1639:
1608:
1604:
1553:
1549:
1538:
1511:
1507:
1497:
1452:
1448:
1438:
1393:
1389:
1379:
1352:
1348:
1337:
1300:
1296:
1255:
1251:
1222:
1213:
1204:
1195:
1186:
1093:
1084:chlorpyrifos
1081:
1077:
1065:
1054:
1046:
1022:
1014:
1006:
1002:
998:
997:
920:
898:NP_001139750
894:NP_001139749
890:NP_001139748
887:
861:
843:NM_001146278
839:NM_001146277
835:NM_001146276
828:
804:
785:
759:
740:
714:
695:
675:
670:
466:right kidney
462:human kidney
346:
339:
204:172,711,218
191:172,630,249
66:External IDs
29:
2670:Active site
2589:Nuclease S1
2360:Exonuclease
2254:Lecithinase
2083:Calcineurin
2021:Phosphatase
1927:Lipoprotein
1917:Endothelial
1104:amino acids
305:27,338,757
292:27,237,114
284:3|3 A3
44:Identifiers
2942:Categories
2873:Isomerases
2847:Hydrolases
2714:Regulation
1902:Pancreatic
1839:Carboxylic
1181:, May 2017
1160:, May 2017
1137:References
1094:NCEH is a
611:metabolism
350:(ortholog)
87:HomoloGene
2752:EC number
2479:RNase III
2337:(includes
2278:Sulfatase
2191:Autotaxin
2055:Prostatic
1907:Lysosomal
1822:esterases
1818:Hydrolase
1116:Autotaxin
1090:Structure
923:NP_848887
902:NP_065843
864:NM_178772
831:NM_020792
661:Orthologs
95:GeneCards
2953:EC 3.1.1
2776:Kinetics
2700:Cofactor
2663:Activity
2573:RNase T1
2335:Nuclease
1970:Cutinase
1779:20947831
1743:20353815
1721:Genomics
1708:18782767
1662:17052608
1627:17052604
1582:18782767
1530:16449251
1489:15840715
1430:12149457
1371:20947831
1329:20625037
1274:17052608
1177:–
1156:–
1110:See also
1043:Function
1007:KIAA1363
971:Wikidata
640:Sources:
590:membrane
18:KIAA1363
2932:Biology
2886:Ligases
2656:Enzymes
2546:RNase E
2541:RNase Z
2536:RNase A
2531:RNase P
2504:RNase H
2122:Phytase
1922:Hepatic
1897:Lingual
1893:Gastric
1699:2662263
1573:2662263
1480:1087944
1457:Bibcode
1398:Bibcode
1320:2936755
1179:Ensembl
1158:Ensembl
773:UniProt
728:Ensembl
667:Species
646:QuickGO
454:utricle
325:pattern
183:3q26.31
83:2443191
51:Aliases
2918:Portal
2860:Lyases
2484:Drosha
2409:3.1.21
2377:RecBCD
2355:3.1.11
1975:PETase
1883:Lipase
1777:
1741:
1706:
1696:
1660:
1625:
1580:
1570:
1528:
1487:
1477:
1428:
1421:124915
1418:
1369:
1327:
1317:
1272:
1106:long.
1011:enzyme
1009:is an
957:search
955:PubMed
806:Q8BLF1
787:Q6PIU2
716:320024
683:Entrez
496:BioGPS
75:613234
2812:Types
2493:Dicer
2448:;see
2274:3.1.6
2244:PDE4B
2240:PDE4A
2178:3.1.4
2147:IMPA3
2143:IMPA2
2139:IMPA1
2017:3.1.3
1985:3.1.2
1835:3.1.1
1015:NCEH1
697:57552
676:Mouse
671:Human
642:Amigo
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
99:NCEH1
91:23251
58:NCEH1
35:NCEH1
2904:list
2897:EC7
2891:list
2884:EC6
2878:list
2871:EC5
2865:list
2858:EC4
2852:list
2845:EC3
2839:list
2832:EC2
2826:list
2819:EC1
2411:-31:
2357:-16:
2343:and
2249:PDE5
2235:PDE3
2230:PDE2
2225:PDE1
2117:PTEN
2102:OCRL
2095:PP2A
2044:ALPP
2039:ALPL
2034:ALPI
1828:3.1)
1775:PMID
1739:PMID
1704:PMID
1658:PMID
1623:PMID
1578:PMID
1526:PMID
1485:PMID
1426:PMID
1367:PMID
1325:PMID
1270:PMID
1035:and
1018:gene
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
71:OMIM
2566:4/5
1765:doi
1761:107
1729:doi
1694:PMC
1684:doi
1680:283
1648:doi
1613:doi
1568:PMC
1558:doi
1554:283
1516:doi
1475:PMC
1465:doi
1453:102
1416:PMC
1406:doi
1357:doi
1353:107
1315:PMC
1305:doi
1260:doi
504:n/a
301:End
200:End
103:OMA
79:MGI
2944::
2524:2C
2519:2B
2514:2A
2495::
2486::
2276::
2156::
2145:,
2141:,
2057:)/
2019::
1987::
1956:A2
1951:A1
1837::
1826:EC
1820::
1773:.
1759:.
1755:.
1737:.
1725:96
1723:.
1719:.
1702:.
1692:.
1678:.
1674:.
1656:.
1644:13
1642:.
1638:.
1621:.
1609:13
1607:.
1603:.
1576:.
1566:.
1552:.
1548:.
1524:.
1512:91
1510:.
1506:.
1483:.
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