336:
313:
235:
210:
601:
587:
594:
342:
241:
1468:. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor-like domains of various proteins.
3355:
3372:
49:
75:
2268:
Ho SP, Scully MS, Krauthauser CM, Wexler EJ, Stow MD, Dinchuk JE, et al. (August 2002). "Antisense oligonucleotides selectively regulate aspartyl beta-hydroxylase and its truncated protein isoform in vitro but distribute poorly into A549 tumors in vivo".
2549:
Feldmann G, Nattermann J, Nischalke HD, GorschlĂĽter M, Kuntzen T, Ahlenstiel G, et al. (June 2006). "Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer".
2359:
Maeda T, Sepe P, Lahousse S, Tamaki S, Enjoji M, Wands JR, de la Monte SM (May 2003). "Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) beta-hydroxylase suppress migration of cholangiocarcinoma cells".
2973:
2669:
349:
248:
2842:
2587:
Gundogan F, Elwood G, Greco D, Rubin LP, Pinar H, Carlson RI, et al. (January 2007). "Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy loss".
2878:
2165:"Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane"
1782:
Palumbo KS, Wands JR, Safran H, King T, Carlson RI, de la Monte SM (July 2002). "Human aspartyl (asparaginyl) beta-hydroxylase monoclonal antibodies: potential biomarkers for pancreatic carcinoma".
2947:
2910:
2969:
2742:
2520:
de la Monte SM, Tamaki S, Cantarini MC, Ince N, Wiedmann M, Carter JJ, et al. (May 2006). "Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness".
1744:
Xue T, Xue XP, Huang QS, Wei L, Sun K, Xue T (August 2009). "Monoclonal antibodies against human aspartyl (asparaginyl) beta-hydroxylase developed by DNA immunization".
1714:
Ince N, de la Monte SM, Wands JR (March 2000). "Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation".
2066:"Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane"
1528:
1004:
157:
1887:"Mutations in ASPH cause facial dysmorphism, lens dislocation, anterior-segment abnormalities, and spontaneous filtering blebs, or Traboulsi syndrome"
985:
1609:
1591:
2130:"Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin"
1938:
1450:
1372:
1627:
Korioth F, Gieffers C, Frey J (December 1994). "Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase".
2832:
1379:
2725:
1700:
3451:
2900:
2639:
2997:
3417:
1574:
3436:
72:
2617:
1944:
2800:
1553:
1825:
3074:
2773:
2391:"Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion"
335:
2023:"Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma"
2812:
2758:
1578:
1557:
312:
2099:
Wetzel GT, Ding S, Chen F (March 2000). "Molecular cloning of junctin from human and developing rabbit heart".
1049:
2487:"Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma"
3441:
3230:
1030:
234:
209:
137:
3041:
2890:
1850:
Hampton T (November 2007). "New screening techniques show potential for early detection of lung cancer".
2389:
Treves S, Franzini-Armstrong C, Moccagatta L, Arnoult C, Grasso C, Schrum A, et al. (August 2004).
1662:
Lim KY, Hong CS, Kim DH (September 2000). "cDNA cloning and characterization of human cardiac junctin".
3345:
2632:
2306:
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002).
348:
247:
3410:
3331:
3318:
3305:
3292:
3279:
3266:
3253:
3215:
3036:
2987:
2959:
2927:
1818:
341:
240:
2021:
Lavaissiere L, Jia S, Nishiyama M, de la Monte S, Stern AM, Wands JR, Friedman PA (September 1996).
3225:
3179:
3122:
2660:
1347:
1343:
1339:
1335:
1325:
1321:
1317:
1313:
1309:
1274:
1270:
1260:
1256:
1252:
1248:
1244:
1216:
1212:
1208:
1204:
1194:
1190:
1186:
1182:
1178:
1143:
1139:
1129:
1125:
1121:
1117:
1113:
181:
145:
124:
3127:
2882:
2673:
2198:
Kirchhefer U, Neumann J, Baba HA, Begrow F, Kobayashi YM, Reinke U, et al. (February 2001).
17:
2432:
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004).
2308:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1480:
was recognized as an indicator of carcinoma in humans. Further research has correlated elevated
1355:
1351:
1294:
1290:
1286:
1282:
1278:
1224:
1220:
1163:
1159:
1155:
1151:
1147:
820:
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
3021:
2937:
2686:
3148:
3067:
2817:
2790:
2625:
187:
3403:
3220:
2932:
2895:
2656:
2647:
2445:
2319:
223:
33:
165:
8:
3446:
3184:
2918:
2233:
Sepe PS, Lahousse SA, Gemelli B, Chang H, Maeda T, Wands JR, de la Monte SM (July 2002).
2200:"Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1"
1950:
2449:
2323:
2128:
Dinchuk JE, Henderson NL, Burn TC, Huber R, Ho SP, Link J, et al. (December 2000).
1885:
Patel N, Khan AO, Mansour A, Mohamed JY, Al-Assiri A, Haddad R, et al. (May 2014).
3117:
2681:
2575:
2415:
2390:
2294:
2251:
2235:"Role of the aspartyl-asparaginyl-beta-hydroxylase gene in neuroblastoma cell motility"
2234:
1911:
1886:
1807:
870:
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
169:
2827:
2468:
2433:
2373:
2342:
2307:
2047:
2022:
1675:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
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834:
829:
824:
819:
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804:
799:
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784:
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763:
758:
753:
748:
743:
738:
733:
728:
723:
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713:
708:
703:
687:
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667:
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657:
652:
647:
642:
2715:
2605:
2567:
2537:
2508:
2473:
2420:
2377:
2347:
2286:
2256:
2221:
2186:
2151:
2116:
2087:
2052:
2009:
1966:
1957:
1916:
1867:
1799:
1795:
1761:
1723:
1679:
1644:
1640:
1504:
1500:
795:
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
117:
65:
2579:
149:
3163:
3158:
3132:
3060:
2597:
2559:
2529:
2498:
2463:
2453:
2410:
2402:
2369:
2337:
2327:
2298:
2278:
2246:
2211:
2176:
2141:
2108:
2077:
2042:
2034:
1999:
1906:
1898:
1859:
1811:
1791:
1753:
1671:
1636:
428:
359:
303:
258:
2601:
3210:
3194:
3107:
2805:
1988:"Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases"
1508:
403:
173:
1614:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1596:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3387:
3359:
3248:
3189:
3031:
3011:
3006:
2648:
2533:
2438:
Proceedings of the
National Academy of Sciences of the United States of America
2312:
Proceedings of the
National Academy of Sciences of the United States of America
2004:
1987:
1902:
1496:
504:
3391:
2503:
2486:
3430:
3153:
3112:
2082:
2065:
1863:
629:
600:
586:
2458:
564:
442:
128:, AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin, aspartate beta-hydroxylase
3383:
3102:
2850:
2846:
2609:
2571:
2541:
2512:
2477:
2424:
2381:
2351:
2332:
2290:
2282:
2260:
2225:
2216:
2199:
2190:
2181:
2164:
2155:
2146:
2129:
2120:
2112:
2013:
1920:
1871:
1829:
1803:
1765:
1727:
1683:
840:
positive regulation of ryanodine-sensitive calcium-release channel activity
593:
421:
200:
2563:
2406:
2163:
Treves S, Feriotto G, Moccagatta L, Gambari R, Zorzato F (December 2000).
2091:
2064:
Zhang L, Kelley J, Schmeisser G, Kobayashi YM, Jones LR (September 1997).
2056:
1757:
1648:
1419:
1414:
3326:
3261:
3097:
2388:
1519:
only in diseased tissue, but not in adjacent normal and inflamed tissue.
1512:
1485:
1465:
1094:
1075:
2982:
320:
217:
153:
2548:
2239:
Laboratory
Investigation; A Journal of Technical Methods and Pathology
2038:
94:
3300:
3274:
2951:
2914:
2858:
2652:
1493:
949:
387:
374:
286:
273:
161:
1826:"CC Detect - Serum-Based Diagnostic Test For Colon Cancer Available"
3354:
2730:
2485:
Xian ZH, Zhang SH, Cong WM, Yan HX, Wang K, Wu MC (February 2006).
2434:"Large-scale characterization of HeLa cell nuclear phosphoproteins"
2431:
1403:
2020:
790:
regulation of ryanodine-sensitive calcium-release channel activity
3026:
1971:
1961:
1462:
1061:
1016:
934:
930:
141:
3313:
3083:
2868:
2863:
2822:
2162:
1439:
1387:
971:
2519:
2063:
609:
3287:
3015:
2750:
2708:
2701:
2696:
2691:
2305:
1489:
1956:
Overview of all the structural information available in the
3379:
3371:
2795:
2783:
2778:
2768:
2763:
2746:
2720:
2197:
1446:
3052:
2271:
The
Journal of Pharmacology and Experimental Therapeutics
2267:
2127:
815:
positive regulation of calcium ion transport into cytosol
2586:
2232:
411:
2358:
1884:
865:
regulation of cell communication by electrical coupling
48:
1781:
785:
positive regulation of intracellular protein transport
3343:
875:
activation of store-operated calcium channel activity
576:
1713:
885:
negative regulation of cell population proliferation
739:
integral component of endoplasmic reticulum membrane
1992:
1626:
1453:, a superfamily non-haem iron-containing proteins.
835:
positive regulation of transcription, DNA-templated
1570:
1568:
1566:
1549:
1547:
1545:
1461:This gene is thought to play an important role in
850:activation of cysteine-type endopeptidase activity
358:
257:
3428:
2484:
1970:(Aspartyl/asparaginyl beta-hydroxylase) at the
1777:
1775:
1563:
1542:
2098:
1743:
1701:"Entrez Gene: ASPH aspartate beta-hydroxylase"
1575:GRCm38: Ensembl release 89: ENSMUSG00000028207
3411:
3068:
2633:
1985:
688:peptidyl-aspartic acid 3-dioxygenase activity
1843:
1772:
1655:
1554:GRCh38: Ensembl release 89: ENSG00000198363
3418:
3404:
3075:
3061:
2640:
2626:
1739:
1737:
1661:
1620:
729:junctional sarcoplasmic reticulum membrane
2502:
2467:
2457:
2414:
2341:
2331:
2250:
2215:
2180:
2145:
2081:
2046:
2003:
1910:
1476:As early as 1996, the over-expression of
1451:alpha-ketoglutarate-dependent hydroxylase
1707:
1695:
1693:
1484:levels (variously in affected tissue or
1471:
1849:
1734:
1515:. The pancreatic study showed elevated
14:
3429:
1986:Hirota K, Semenza GL (December 2005).
915:regulation of protein depolymerization
3056:
2621:
2027:The Journal of Clinical Investigation
1690:
1432:Aspartyl/asparaginyl beta-hydroxylase
363:
324:
319:
262:
221:
216:
3366:
2833:24-hydroxycholesterol 7α-hydroxylase
900:peptidyl-aspartic acid hydroxylation
2204:The Journal of Biological Chemistry
2169:The Journal of Biological Chemistry
2134:The Journal of Biological Chemistry
2070:The Journal of Biological Chemistry
855:calcium ion transmembrane transport
535:medial head of gastrocnemius muscle
24:
2252:10.1097/01.lab.0000020406.91689.7f
1978:
1891:American Journal of Human Genetics
860:positive regulation of proteolysis
34:Aspheric lens § Camera lenses
25:
3463:
2101:Molecular Genetics and Metabolism
1931:
1442:that in humans is encoded by the
643:transmembrane transporter binding
27:Protein and coding gene in humans
3370:
3353:
1796:10.1097/00006676-200207000-00010
825:peptidyl-amino acid modification
805:regulation of cardiac conduction
780:cellular response to calcium ion
678:structural constituent of muscle
599:
592:
585:
347:
340:
334:
311:
246:
239:
233:
208:
47:
2813:Cholesterol 7 alpha-hydroxylase
2759:Flavin-containing monooxygenase
1878:
890:regulation of protein stability
744:sarcoplasmic reticulum membrane
1602:
1584:
754:endoplasmic reticulum membrane
724:cortical endoplasmic reticulum
704:integral component of membrane
610:More reference expression data
565:More reference expression data
13:
1:
3452:Human chromosome 8 gene stubs
2602:10.1016/j.humpath.2006.06.005
2374:10.1016/S0168-8278(03)00052-7
1676:10.1016/S0378-1119(00)00299-7
1535:
880:pattern specification process
332:
231:
3390:. You can help Knowledge by
1641:10.1016/0378-1119(94)90460-X
749:sarcoplasmic reticulum lumen
653:structural molecule activity
7:
3437:Genes on human chromosome 8
3082:
3042:Deoxyhypusine monooxygenase
2395:The Journal of Cell Biology
1456:
845:ion transmembrane transport
457:stromal cell of endometrium
10:
3468:
3365:
2534:10.1016/j.jhep.2006.01.038
2005:10.1016/j.bbrc.2005.08.193
1949:gene details page in the
1903:10.1016/j.ajhg.2014.04.002
668:electron transfer activity
531:sternocleidomastoid muscle
31:
3239:
3231:Michaelis–Menten kinetics
3203:
3172:
3141:
3090:
3037:Ecdysone 20-monooxygenase
2996:
2988:Stearoyl-CoA desaturase-1
2968:
2960:Dopamine beta-hydroxylase
2946:
2928:Phenylalanine hydroxylase
2909:
2877:
2841:
2741:
2668:
2504:10.1038/modpathol.3800530
1610:"Mouse PubMed Reference:"
1592:"Human PubMed Reference:"
1418:
1413:
1409:
1402:
1386:
1367:
1332:
1308:
1267:
1243:
1236:
1201:
1177:
1136:
1112:
1105:
1092:
1088:
1073:
1069:
1060:
1047:
1043:
1028:
1024:
1015:
1002:
998:
983:
979:
970:
955:
948:
944:
928:
905:roof of mouth development
628:
624:
607:
584:
575:
562:
511:
502:
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
185:
180:
135:
132:
122:
115:
110:
91:
86:
69:
64:
59:
55:
46:
41:
3123:Diffusion-limited enzyme
2083:10.1074/jbc.272.37.23389
1864:10.1001/jama.298.17.1997
920:electron transport chain
830:detection of calcium ion
527:tibialis anterior muscle
2459:10.1073/pnas.0404720101
1488:) with hepatocellular (
709:calcium channel complex
673:oxidoreductase activity
551:interventricular septum
515:vastus lateralis muscle
32:For camera lenses, see
3022:Squalene monooxygenase
2938:Tryptophan hydroxylase
2687:HIF prolyl-hydroxylase
2333:10.1073/pnas.242603899
2283:10.1124/jpet.302.2.795
2217:10.1074/jbc.M006443200
2182:10.1074/jbc.M005473200
2147:10.1074/jbc.M006753200
2113:10.1006/mgme.2000.2966
1373:Chr 8: 61.5 – 61.71 Mb
734:sarcoplasmic reticulum
519:triceps brachii muscle
3216:Eadie–Hofstee diagram
3149:Allosteric regulation
2818:Methane monooxygenase
2791:Nitric oxide synthase
2564:10.1055/s-2006-925065
2522:Journal of Hepatology
2407:10.1083/jcb.200404079
2362:Journal of Hepatology
1758:10.1089/hyb.2009.0017
1472:Clinical significance
1380:Chr 4: 9.45 – 9.67 Mb
759:endoplasmic reticulum
461:palpebral conjunctiva
3442:Human 2OG oxygenases
3226:Lineweaver–Burk plot
2933:Tyrosine hydroxylase
2657:steroid hydroxylases
1943:genome location and
648:dioxygenase activity
473:right adrenal cortex
326:Chromosome 4 (mouse)
224:Chromosome 8 (human)
87:List of PDB id codes
60:Available structures
2883:iron–sulfur protein
2450:2004PNAS..10112130B
2324:2002PNAS...9916899M
1951:UCSC Genome Browser
683:calcium ion binding
485:left adrenal cortex
481:germinal epithelium
469:islet of Langerhans
465:epithelium of colon
3378:This article on a
3185:Enzyme superfamily
3118:Enzyme promiscuity
2682:Prolyl hydroxylase
1529:Traboulsi syndrome
1050:ENSMUSG00000028207
910:face morphogenesis
895:limb morphogenesis
810:muscle contraction
773:Biological process
697:Cellular component
636:Molecular function
477:left adrenal gland
3399:
3398:
3341:
3340:
3050:
3049:
2716:Lysyl hydroxylase
2318:(26): 16899–903.
2039:10.1172/JCI118918
1505:colorectal cancer
1501:pancreatic cancer
1429:
1428:
1425:
1424:
1398:
1397:
1363:
1362:
1302:
1301:
1232:
1231:
1171:
1170:
1101:
1100:
1082:
1081:
1056:
1055:
1037:
1036:
1011:
1010:
992:
991:
940:
939:
658:metal ion binding
620:
619:
616:
615:
571:
570:
558:
557:
496:
495:
394:
393:
293:
292:
106:
105:
102:
101:
70:Ortholog search:
16:(Redirected from
3459:
3420:
3413:
3406:
3374:
3367:
3358:
3357:
3349:
3221:Hanes–Woolf plot
3164:Enzyme activator
3159:Enzyme inhibitor
3133:Enzyme catalysis
3077:
3070:
3063:
3054:
3053:
2642:
2635:
2628:
2619:
2618:
2613:
2583:
2545:
2516:
2506:
2491:Modern Pathology
2481:
2471:
2461:
2428:
2418:
2385:
2355:
2345:
2335:
2302:
2264:
2254:
2229:
2219:
2194:
2184:
2175:(50): 39555–68.
2159:
2149:
2140:(50): 39543–54.
2124:
2095:
2085:
2076:(37): 23389–97.
2060:
2050:
2017:
2007:
1925:
1924:
1914:
1882:
1876:
1875:
1847:
1841:
1840:
1838:
1837:
1828:. Archived from
1822:
1816:
1815:
1779:
1770:
1769:
1741:
1732:
1731:
1711:
1705:
1704:
1697:
1688:
1687:
1659:
1653:
1652:
1624:
1618:
1617:
1606:
1600:
1599:
1588:
1582:
1572:
1561:
1551:
1411:
1410:
1382:
1375:
1358:
1306:
1305:
1297:
1241:
1240:
1237:RefSeq (protein)
1227:
1175:
1174:
1166:
1110:
1109:
1086:
1085:
1067:
1066:
1041:
1040:
1022:
1021:
996:
995:
977:
976:
946:
945:
626:
625:
612:
603:
596:
589:
582:
581:
567:
547:digastric muscle
507:
505:Top expressed in
500:
499:
445:
443:Top expressed in
438:
437:
417:
416:
400:
399:
390:
377:
366:
351:
344:
338:
327:
315:
299:
298:
289:
276:
265:
250:
243:
237:
226:
212:
196:
195:
190:
176:
174:ASPH - orthologs
127:
120:
97:
84:
83:
78:
57:
56:
51:
39:
38:
21:
3467:
3466:
3462:
3461:
3460:
3458:
3457:
3456:
3427:
3426:
3425:
3424:
3364:
3352:
3344:
3342:
3337:
3249:Oxidoreductases
3235:
3211:Enzyme kinetics
3199:
3195:List of enzymes
3168:
3137:
3108:Catalytic triad
3086:
3081:
3051:
3046:
3000:- miscellaneous
2992:
2964:
2942:
2905:
2873:
2837:
2828:14α-demethylase
2737:
2664:
2649:Oxidoreductases
2646:
2616:
2590:Human Pathology
2444:(33): 12130–5.
1981:
1979:Further reading
1934:
1929:
1928:
1883:
1879:
1848:
1844:
1835:
1833:
1824:
1823:
1819:
1780:
1773:
1742:
1735:
1716:Cancer Research
1712:
1708:
1699:
1698:
1691:
1660:
1656:
1625:
1621:
1608:
1607:
1603:
1590:
1589:
1585:
1573:
1564:
1552:
1543:
1538:
1509:prostate cancer
1474:
1459:
1420:View/Edit Mouse
1415:View/Edit Human
1378:
1371:
1368:Location (UCSC)
1354:
1350:
1346:
1342:
1338:
1334:
1328:
1324:
1320:
1316:
1312:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1263:
1259:
1255:
1251:
1247:
1223:
1219:
1215:
1211:
1207:
1203:
1197:
1193:
1189:
1185:
1181:
1162:
1158:
1154:
1150:
1146:
1142:
1138:
1132:
1128:
1124:
1120:
1116:
1031:ENSG00000198363
924:
800:response to ATP
768:
719:plasma membrane
692:
663:protein binding
608:
598:
597:
591:
590:
563:
554:
549:
545:
541:
539:muscle of thigh
537:
533:
529:
525:
523:temporal muscle
521:
517:
503:
492:
487:
483:
479:
475:
471:
467:
463:
459:
455:
453:Achilles tendon
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
186:
136:
123:
116:
93:
71:
37:
28:
23:
22:
15:
12:
11:
5:
3465:
3455:
3454:
3449:
3444:
3439:
3423:
3422:
3415:
3408:
3400:
3397:
3396:
3375:
3363:
3362:
3339:
3338:
3336:
3335:
3322:
3309:
3296:
3283:
3270:
3257:
3243:
3241:
3237:
3236:
3234:
3233:
3228:
3223:
3218:
3213:
3207:
3205:
3201:
3200:
3198:
3197:
3192:
3187:
3182:
3176:
3174:
3173:Classification
3170:
3169:
3167:
3166:
3161:
3156:
3151:
3145:
3143:
3139:
3138:
3136:
3135:
3130:
3125:
3120:
3115:
3110:
3105:
3100:
3094:
3092:
3088:
3087:
3080:
3079:
3072:
3065:
3057:
3048:
3047:
3045:
3044:
3039:
3034:
3029:
3024:
3019:
3012:Heme oxygenase
3009:
3007:Cyclooxygenase
3003:
3001:
2994:
2993:
2991:
2990:
2985:
2979:
2977:
2966:
2965:
2963:
2962:
2956:
2954:
2944:
2943:
2941:
2940:
2935:
2930:
2924:
2922:
2907:
2906:
2904:
2903:
2898:
2893:
2887:
2885:
2875:
2874:
2872:
2871:
2866:
2861:
2855:
2853:
2839:
2838:
2836:
2835:
2830:
2825:
2820:
2815:
2810:
2809:
2808:
2803:
2798:
2788:
2787:
2786:
2781:
2776:
2771:
2766:
2755:
2753:
2739:
2738:
2736:
2735:
2734:
2733:
2728:
2718:
2713:
2712:
2711:
2706:
2705:
2704:
2699:
2694:
2678:
2676:
2674:2-oxoglutarate
2666:
2665:
2645:
2644:
2637:
2630:
2622:
2615:
2614:
2584:
2546:
2517:
2482:
2429:
2386:
2356:
2303:
2277:(2): 795–803.
2265:
2230:
2195:
2160:
2125:
2096:
2061:
2033:(6): 1313–23.
2018:
1982:
1980:
1977:
1976:
1975:
1954:
1933:
1932:External links
1930:
1927:
1926:
1877:
1842:
1817:
1771:
1733:
1706:
1689:
1654:
1619:
1601:
1583:
1562:
1540:
1539:
1537:
1534:
1497:adenocarcinoma
1473:
1470:
1458:
1455:
1427:
1426:
1423:
1422:
1417:
1407:
1406:
1400:
1399:
1396:
1395:
1393:
1391:
1384:
1383:
1376:
1369:
1365:
1364:
1361:
1360:
1330:
1329:
1303:
1300:
1299:
1265:
1264:
1238:
1234:
1233:
1230:
1229:
1199:
1198:
1172:
1169:
1168:
1134:
1133:
1107:
1103:
1102:
1099:
1098:
1090:
1089:
1083:
1080:
1079:
1071:
1070:
1064:
1058:
1057:
1054:
1053:
1045:
1044:
1038:
1035:
1034:
1026:
1025:
1019:
1013:
1012:
1009:
1008:
1000:
999:
993:
990:
989:
981:
980:
974:
968:
967:
962:
957:
953:
952:
942:
941:
938:
937:
926:
925:
923:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
776:
774:
770:
769:
767:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
700:
698:
694:
693:
691:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
639:
637:
633:
632:
622:
621:
618:
617:
614:
613:
605:
604:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
509:
508:
497:
494:
493:
491:
490:
489:adipose tissue
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
254:
245:
238:
232:
228:
227:
220:
214:
213:
205:
204:
192:
191:
184:
178:
177:
134:
130:
129:
121:
113:
112:
108:
107:
104:
103:
100:
99:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
26:
9:
6:
4:
3:
2:
3464:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3434:
3432:
3421:
3416:
3414:
3409:
3407:
3402:
3401:
3395:
3393:
3389:
3385:
3381:
3376:
3373:
3369:
3368:
3361:
3356:
3351:
3350:
3347:
3333:
3329:
3328:
3323:
3320:
3316:
3315:
3310:
3307:
3303:
3302:
3297:
3294:
3290:
3289:
3284:
3281:
3277:
3276:
3271:
3268:
3264:
3263:
3258:
3255:
3251:
3250:
3245:
3244:
3242:
3238:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3208:
3206:
3202:
3196:
3193:
3191:
3190:Enzyme family
3188:
3186:
3183:
3181:
3178:
3177:
3175:
3171:
3165:
3162:
3160:
3157:
3155:
3154:Cooperativity
3152:
3150:
3147:
3146:
3144:
3140:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3113:Oxyanion hole
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3095:
3093:
3089:
3085:
3078:
3073:
3071:
3066:
3064:
3059:
3058:
3055:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3017:
3013:
3010:
3008:
3005:
3004:
3002:
2999:
2995:
2989:
2986:
2984:
2981:
2980:
2978:
2975:
2971:
2967:
2961:
2958:
2957:
2955:
2953:
2949:
2945:
2939:
2936:
2934:
2931:
2929:
2926:
2925:
2923:
2920:
2919:BH4 dependent
2916:
2912:
2908:
2902:
2899:
2897:
2894:
2892:
2889:
2888:
2886:
2884:
2880:
2876:
2870:
2867:
2865:
2862:
2860:
2857:
2856:
2854:
2852:
2848:
2844:
2840:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2807:
2804:
2802:
2799:
2797:
2794:
2793:
2792:
2789:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2761:
2760:
2757:
2756:
2754:
2752:
2748:
2744:
2740:
2732:
2729:
2727:
2724:
2723:
2722:
2719:
2717:
2714:
2710:
2707:
2703:
2700:
2698:
2695:
2693:
2690:
2689:
2688:
2685:
2684:
2683:
2680:
2679:
2677:
2675:
2671:
2667:
2662:
2658:
2654:
2650:
2643:
2638:
2636:
2631:
2629:
2624:
2623:
2620:
2611:
2607:
2603:
2599:
2595:
2591:
2585:
2581:
2577:
2573:
2569:
2565:
2561:
2557:
2553:
2547:
2543:
2539:
2535:
2531:
2528:(5): 971–83.
2527:
2523:
2518:
2514:
2510:
2505:
2500:
2496:
2492:
2488:
2483:
2479:
2475:
2470:
2465:
2460:
2455:
2451:
2447:
2443:
2439:
2435:
2430:
2426:
2422:
2417:
2412:
2408:
2404:
2401:(4): 537–48.
2400:
2396:
2392:
2387:
2383:
2379:
2375:
2371:
2368:(5): 615–22.
2367:
2363:
2357:
2353:
2349:
2344:
2339:
2334:
2329:
2325:
2321:
2317:
2313:
2309:
2304:
2300:
2296:
2292:
2288:
2284:
2280:
2276:
2272:
2266:
2262:
2258:
2253:
2248:
2245:(7): 881–91.
2244:
2240:
2236:
2231:
2227:
2223:
2218:
2213:
2210:(6): 4142–9.
2209:
2205:
2201:
2196:
2192:
2188:
2183:
2178:
2174:
2170:
2166:
2161:
2157:
2153:
2148:
2143:
2139:
2135:
2131:
2126:
2122:
2118:
2114:
2110:
2106:
2102:
2097:
2093:
2089:
2084:
2079:
2075:
2071:
2067:
2062:
2058:
2054:
2049:
2044:
2040:
2036:
2032:
2028:
2024:
2019:
2015:
2011:
2006:
2001:
1997:
1993:
1989:
1984:
1983:
1973:
1969:
1968:
1963:
1959:
1955:
1952:
1948:
1947:
1942:
1941:
1936:
1935:
1922:
1918:
1913:
1908:
1904:
1900:
1896:
1892:
1888:
1881:
1873:
1869:
1865:
1861:
1857:
1853:
1846:
1832:on 2021-02-08
1831:
1827:
1821:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1785:
1778:
1776:
1767:
1763:
1759:
1755:
1751:
1747:
1740:
1738:
1729:
1725:
1722:(5): 1261–6.
1721:
1717:
1710:
1702:
1696:
1694:
1685:
1681:
1677:
1673:
1669:
1665:
1658:
1650:
1646:
1642:
1638:
1634:
1630:
1623:
1615:
1611:
1605:
1597:
1593:
1587:
1580:
1576:
1571:
1569:
1567:
1559:
1555:
1550:
1548:
1546:
1541:
1533:
1531:
1530:
1525:
1522:Mutations in
1520:
1518:
1514:
1510:
1506:
1502:
1498:
1495:
1491:
1487:
1483:
1479:
1469:
1467:
1464:
1454:
1452:
1449:. ASPH is an
1448:
1445:
1441:
1437:
1433:
1421:
1416:
1412:
1408:
1405:
1401:
1394:
1392:
1389:
1385:
1381:
1377:
1374:
1370:
1366:
1359:
1357:
1353:
1349:
1345:
1341:
1337:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1304:
1298:
1296:
1292:
1288:
1284:
1280:
1276:
1272:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1239:
1235:
1228:
1226:
1222:
1218:
1214:
1210:
1206:
1200:
1196:
1192:
1188:
1184:
1180:
1176:
1173:
1167:
1165:
1161:
1157:
1153:
1149:
1145:
1141:
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1108:
1106:RefSeq (mRNA)
1104:
1097:
1096:
1091:
1087:
1084:
1078:
1077:
1072:
1068:
1065:
1063:
1059:
1052:
1051:
1046:
1042:
1039:
1033:
1032:
1027:
1023:
1020:
1018:
1014:
1007:
1006:
1001:
997:
994:
988:
987:
982:
978:
975:
973:
969:
966:
963:
961:
958:
954:
951:
947:
943:
936:
932:
927:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
777:
775:
772:
771:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
701:
699:
696:
695:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
635:
634:
631:
630:Gene ontology
627:
623:
611:
606:
602:
595:
588:
583:
580:
578:
574:
566:
561:
550:
546:
543:soleus muscle
542:
538:
534:
530:
526:
522:
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
131:
126:
119:
114:
109:
98:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
35:
30:
19:
3392:expanding it
3384:chromosome 8
3377:
3327:Translocases
3324:
3311:
3298:
3285:
3272:
3262:Transferases
3259:
3246:
3103:Binding site
2851:flavoprotein
2655:, including
2653:dioxygenases
2593:
2589:
2558:(6): 604–9.
2555:
2551:
2525:
2521:
2497:(2): 280–6.
2494:
2490:
2441:
2437:
2398:
2394:
2365:
2361:
2315:
2311:
2274:
2270:
2242:
2238:
2207:
2203:
2172:
2168:
2137:
2133:
2107:(3): 252–8.
2104:
2100:
2073:
2069:
2030:
2026:
1998:(1): 610–6.
1995:
1991:
1965:
1945:
1939:
1897:(5): 755–9.
1894:
1890:
1880:
1858:(17): 1997.
1855:
1851:
1845:
1834:. Retrieved
1830:the original
1820:
1790:(1): 39–44.
1787:
1783:
1752:(4): 251–7.
1749:
1745:
1719:
1715:
1709:
1670:(1): 35–42.
1667:
1663:
1657:
1635:(2): 395–9.
1632:
1628:
1622:
1613:
1604:
1595:
1586:
1527:
1523:
1521:
1516:
1481:
1477:
1475:
1460:
1443:
1435:
1431:
1430:
1348:NP_001277296
1344:NP_001171327
1340:NP_001171326
1336:NP_001171325
1333:
1326:NP_001171324
1322:NP_001171323
1318:NP_001171322
1314:NP_001171321
1310:NP_001171320
1275:NP_001158228
1271:NP_001158227
1268:
1261:NP_001158226
1257:NP_001158225
1253:NP_001158224
1249:NP_001158223
1245:NP_001158222
1217:NM_001290367
1213:NM_001177856
1209:NM_001177855
1205:NM_001177854
1202:
1195:NM_001177853
1191:NM_001177852
1187:NM_001177851
1183:NM_001177850
1179:NM_001177849
1144:NM_001164756
1140:NM_001164755
1137:
1130:NM_001164754
1126:NM_001164753
1122:NM_001164752
1118:NM_001164751
1114:NM_001164750
1093:
1074:
1048:
1029:
1003:
984:
964:
959:
427:
420:
133:External IDs
92:
29:
3098:Active site
2596:(1): 50–9.
1513:lung cancer
1486:blood serum
1466:homeostasis
365:4|4 A1
285:61,714,640
272:61,500,556
111:Identifiers
3447:EC 1.14.11
3431:Categories
3301:Isomerases
3275:Hydrolases
3142:Regulation
2983:Tyrosinase
2950:: reduced
2913:: reduced
2881:: reduced
2845:: reduced
1836:2011-11-29
1581:, May 2017
1560:, May 2017
1536:References
431:(ortholog)
386:9,669,344
373:9,448,069
188:1.14.11.16
154:HomoloGene
3382:on human
3180:EC number
2952:ascorbate
2915:pteridine
2552:Endoscopy
1746:Hybridoma
1494:carcinoma
1356:NP_598484
1352:NP_075553
1295:NP_115857
1291:NP_115856
1287:NP_115855
1283:NP_064549
1279:NP_004309
1225:NM_133723
1221:NM_023066
1164:NM_032468
1160:NM_032467
1156:NM_032466
1152:NM_020164
1148:NM_004318
950:Orthologs
764:cytoplasm
182:EC number
162:GeneCards
3204:Kinetics
3128:Cofactor
3091:Activity
2610:16949909
2580:33900440
2572:16673309
2542:16564107
2513:16341145
2478:15302935
2425:15302852
2382:12713872
2352:12477932
2291:12130746
2261:12118090
2226:11069905
2191:11007777
2156:10956665
2121:10767180
2014:16154531
1921:24768550
1872:17986689
1804:12131769
1784:Pancreas
1766:19663697
1728:10728685
1684:10974562
1577:–
1556:–
1457:Function
1438:) is an
1404:Wikidata
929:Sources:
714:membrane
3360:Biology
3314:Ligases
3084:Enzymes
2998:1.14.99
2976:: other
2970:1.14.18
2948:1.14.17
2911:1.14.16
2879:1.14.15
2843:1.14.14
2743:1.14.13
2670:1.14.11
2446:Bibcode
2416:1868564
2320:Bibcode
2299:7167890
2092:9287354
2057:8823296
1972:PDBe-KB
1962:UniProt
1912:4067561
1812:2098747
1649:7821814
1579:Ensembl
1558:Ensembl
1463:calcium
1062:UniProt
1017:Ensembl
956:Species
935:QuickGO
406:pattern
150:1914186
118:Aliases
18:Junctin
3346:Portal
3288:Lyases
2847:flavin
2726:ALKBH1
2608:
2578:
2570:
2540:
2511:
2476:
2469:514446
2466:
2423:
2413:
2380:
2350:
2343:139241
2340:
2297:
2289:
2259:
2224:
2189:
2154:
2119:
2090:
2055:
2048:507557
2045:
2012:
1967:Q12797
1937:Human
1919:
1909:
1870:
1810:
1802:
1764:
1726:
1682:
1647:
1526:cause
1511:. and
1440:enzyme
1390:search
1388:PubMed
1095:Q8BSY0
1076:Q12797
972:Entrez
577:BioGPS
264:8q12.3
142:600582
3386:is a
3240:Types
3016:HMOX1
2751:NADPH
2709:P4HTM
2702:EGLN3
2697:EGLN2
2692:EGLN1
2663:1.14)
2576:S2CID
2295:S2CID
1808:S2CID
1490:liver
1005:65973
965:Mouse
960:Human
931:Amigo
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
158:20910
3388:stub
3380:gene
3332:list
3325:EC7
3319:list
3312:EC6
3306:list
3299:EC5
3293:list
3286:EC4
3280:list
3273:EC3
3267:list
3260:EC2
3254:list
3247:EC1
3032:21A2
3027:17A1
2901:11A1
2896:11B2
2891:11B1
2859:19A1
2806:NOS3
2801:NOS2
2796:NOS1
2784:FMO5
2779:FMO4
2774:FMO3
2769:FMO2
2764:FMO1
2747:NADH
2721:AlkB
2606:PMID
2568:PMID
2538:PMID
2509:PMID
2474:PMID
2421:PMID
2378:PMID
2348:PMID
2287:PMID
2257:PMID
2222:PMID
2187:PMID
2152:PMID
2117:PMID
2088:PMID
2053:PMID
2010:PMID
1960:for
1946:ASPH
1940:ASPH
1917:PMID
1868:PMID
1852:JAMA
1800:PMID
1762:PMID
1724:PMID
1680:PMID
1664:Gene
1645:PMID
1629:Gene
1524:ASPH
1517:HAAH
1482:HAAH
1478:HAAH
1447:gene
1444:ASPH
1436:HAAH
412:Bgee
360:Band
321:Chr.
259:Band
218:Chr.
166:ASPH
138:OMIM
125:ASPH
95:5APA
76:RCSB
73:PDBe
42:ASPH
2869:2E1
2864:2D6
2849:or
2823:3A4
2749:or
2731:FTO
2598:doi
2560:doi
2530:doi
2499:doi
2464:PMC
2454:doi
2442:101
2411:PMC
2403:doi
2399:166
2370:doi
2338:PMC
2328:doi
2279:doi
2275:302
2247:doi
2212:doi
2208:276
2177:doi
2173:275
2142:doi
2138:275
2109:doi
2078:doi
2074:272
2043:PMC
2035:doi
2000:doi
1996:338
1958:PDB
1907:PMC
1899:doi
1860:doi
1856:298
1792:doi
1754:doi
1672:doi
1668:255
1637:doi
1633:150
1503:),
986:444
382:End
281:End
170:OMA
146:MGI
66:PDB
3433::
2974:19
2745::
2672::
2661:EC
2651::
2604:.
2594:38
2592:.
2574:.
2566:.
2556:38
2554:.
2536:.
2526:44
2524:.
2507:.
2495:19
2493:.
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2472:.
2462:.
2452:.
2440:.
2436:.
2419:.
2409:.
2397:.
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2376:.
2366:38
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2041:.
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2029:.
2025:.
2008:.
1994:.
1990:.
1964::
1915:.
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1893:.
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1854:.
1806:.
1798:.
1788:25
1786:.
1774:^
1760:.
1750:28
1748:.
1736:^
1720:60
1718:.
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375:bp
287:bp
274:bp
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164::
160:;
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148::
144:;
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3308:)
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3282:)
3278:(
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2016:.
2002::
1974:.
1953:.
1923:.
1901::
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