520:
497:
419:
394:
4842:
526:
425:
31:
7542:
1953:(JH1-JH7). Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains full kinase function (JH1) while the other (JH2), previously thought to have no kinase functionality and accordingly termed a
3284:
Yamamoto K, Shibata F, Miura O, Kamiyama R, Hirosawa S, Miyasaka N (April 1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus".
57:
3237:"Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation"
2598:
Reiter A, Walz C, Watmore A, Schoch C, Blau I, Schlegelberger B, Berger U, Telford N, Aruliah S, Yin JA, Vanstraelen D, Barker HF, Taylor PC, O'Driscoll A, Benedetti F, Rudolph C, Kolb HJ, Hochhaus A, Hehlmann R, Chase A, Cross NC (April 2005).
2902:
Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, Ihle JN (July 1993). "JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin".
2554:
Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffé M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA (November 1997). "A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia".
3991:
Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (October 1997). "Cloning and characterization of novel CIS family genes".
3565:
Maegawa H, Kashiwagi A, Fujita T, Ugi S, Hasegawa M, Obata T, Nishio Y, Kojima H, Hidaka H, Kikkawa R (November 1996). "SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates".
533:
432:
4246:
Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A (June 1997).
3650:
Wu DW, Stark KC, Dunnington D, Dillon SB, Yi T, Jones C, Pelus LM (February 2000). "SH2-Containing protein tyrosine phosphatase-1 (SHP-1) association with Jak2 in UT-7/Epo cells".
4841:
6541:
3403:"Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription"
2208:
2364:
Brooks AJ, Dai W, O'Mara ML, Abankwa D, Chhabra Y, Pelekanos RA, et al. (2014). "Mechanism of activation of protein kinase JAK2 by the growth hormone receptor".
6687:
3526:"Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis"
4710:
Staerk J, Kallin A, Royer Y, Diaconu CC, Dusa A, Demoulin JB, Vainchenker W, Constantinescu SN (March 2007). "JAK2, the JAK2 V617F mutant and cytokine receptors".
6536:
6471:
3941:"Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain"
2047:, because the receptors for these growth factors require JAK2 for signal transduction. JAK2 mutation, when demonstrable, is one of the methods of diagnosing
3322:"JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation"
6967:
4882:
6606:
1560:
355:
6621:
1541:
6677:
6571:
7379:
6703:
7165:
4560:"Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL"
3235:
Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, Narazaki M, Okumura K, Saitoh H, Nakagawa R, Uchiyama Y, Akira S, Kishimoto T (January 2001).
6586:
6581:
6576:
6566:
6840:
6698:
6667:
6631:
3366:
Fuhrer DK, Yang YC (July 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11".
3159:
Hellgren G, Jansson JO, Carlsson LM, Carlsson B (June 1999). "The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver".
6753:
6718:
5980:
5606:
2305:
2287:
7490:
7185:
6794:
6784:
6774:
6708:
6657:
4117:"STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction"
7419:
7409:
7399:
7336:
7061:
6764:
4156:
Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A (March 1999).
4074:
Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997).
7414:
7331:
7296:
7041:
6813:
6546:
6464:
6030:
5191:
4519:"Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity"
7356:
6531:
3687:"The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity"
2442:
Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O (August 2011).
1823:
7156:
7145:
7121:
6611:
5903:
4875:
4347:"Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1"
3444:"Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin"
1816:
6990:
5538:
5329:
2863:"The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor"
2103:
6500:
5879:
5644:
5548:
2325:"Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice"
4435:
Yamashita Y, Watanabe S, Miyazato A, Ohya Ki, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (March 1998).
3603:"Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1"
2540:
6647:
6457:
5286:
4821:
2270:
7562:
6779:
5314:
2138:
2108:
54:
5682:
5673:
5373:
5368:
5363:
5358:
5025:
4868:
2249:
2168:
6511:
5567:
5558:
4973:
2173:
3196:"Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor"
519:
7465:
6180:
5349:
5058:
1941:
The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (
5252:
2444:"The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling"
2073:
496:
3857:
Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G (May 1997).
4115:
Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K (April 1997).
2274:
2253:
2681:
Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC (April 2005).
7176:
6878:
5184:
3939:
Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A (June 1999).
1605:
3118:
VanderKuur JA, Wang X, Zhang L, Campbell GS, Allevato G, Billestrup N, Norstedt G, Carter-Su C (August 1994).
6336:
5397:
5111:
3728:"Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling"
4158:"The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop"
4076:"An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT"
1586:
7480:
5828:
5760:
5751:
2024:
1883:
418:
393:
335:
6134:
6125:
6105:
6061:
5889:
2060:
3485:"Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases"
3120:"Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase"
7532:
7470:
7112:
5572:
4891:
4850:: The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
532:
431:
2987:
Chauhan D, Kharbanda SM, Ogata A, Urashima M, Frank D, Malik N, Kufe DW, Anderson KC (December 1995).
2601:"The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2"
7567:
7071:
6437:
6424:
6411:
6398:
6385:
6372:
6359:
6321:
5177:
4930:
4814:
2016:
1891:
525:
424:
2822:"ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases"
322:
6331:
6285:
6228:
5222:
5208:
4925:
4793:
3542:
3525:
1795:
1770:
1760:
1756:
1752:
1748:
1744:
1720:
1699:
1695:
1685:
1681:
1677:
1673:
343:
4306:"Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling"
6824:
6520:
6233:
5946:
5937:
2093:
2078:
1950:
1931:
1927:
5169:
4207:"Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor"
1799:
1774:
1724:
1669:
7209:
5235:
3818:"Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2"
2220:
1919:
1907:
1957:, has since been found to be catalytically active, albeit at only 10% that of the JH1 domain.
7021:
7016:
6254:
6173:
5898:
5582:
4899:
4437:"Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription"
3900:"CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2"
2948:"A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn"
2407:
Morgan KJ, Gilliland DG (2008). "A role for JAK2 mutations in myeloproliferative diseases".
7136:
6972:
6326:
4807:
4260:
3077:
Frank SJ, Yi W, Zhao Y, Goldsmith JF, Gilliland G, Jiang J, Sakai I, Kraft AS (June 1995).
2989:"Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells"
2564:
2493:"Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis"
1371:
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
407:
4789:
3079:"Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor"
1126:
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
363:
8:
7087:
6977:
6869:
6290:
5596:
2420:
2005:
1954:
4264:
2568:
7001:
6996:
6962:
6957:
6903:
6491:
6483:
6223:
5970:
5961:
5789:
5780:
4770:
4633:
4608:
4575:
4286:
4182:
4157:
3970:
3261:
3236:
3013:
2988:
2946:
Sayeski PP, Ali MS, Safavi A, Lyles M, Kim SO, Frank SJ, Bernstein KE (November 1999).
2928:
2761:
2522:
2468:
2443:
2389:
2036:
1935:
367:
4757:
4740:
4584:
4559:
4396:"Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK"
4371:
4346:
4133:
4116:
3752:
3727:
3627:
3602:
3136:
3119:
2879:
2862:
2779:
Sarkar S, Pollack BP, Lin KT, Kotenko SV, Cook JR, Lewis A, Pestka S (December 2001).
2509:
2492:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
7429:
6480:
6014:
4963:
4917:
4762:
4727:
4698:
4677:
4638:
4609:"Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling"
4589:
4540:
4499:
4458:
4417:
4376:
4362:
4327:
4278:
4228:
4187:
4138:
4097:
4053:
4009:
3962:
3957:
3940:
3921:
3880:
3839:
3798:
3757:
3708:
3667:
3632:
3583:
3547:
3506:
3465:
3424:
3383:
3343:
3302:
3266:
3217:
3176:
3141:
3100:
3059:
3054:
3037:
3018:
2969:
2920:
2916:
2884:
2843:
2802:
2753:
2712:
2663:
2622:
2580:
2514:
2473:
2424:
2381:
2346:
2048:
2012:
315:
47:
4774:
4394:
Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997).
3974:
2932:
2526:
2393:
7082:
7011:
7006:
6894:
6551:
6269:
6264:
6238:
6166:
5291:
5277:
4752:
4719:
4669:
4628:
4620:
4607:
Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS (August 2010).
4579:
4571:
4530:
4489:
4448:
4407:
4366:
4358:
4317:
4290:
4268:
4218:
4177:
4169:
4128:
4087:
4043:
4001:
3952:
3911:
3898:
Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A (September 2000).
3870:
3829:
3788:
3747:
3739:
3698:
3659:
3622:
3614:
3575:
3537:
3496:
3455:
3414:
3375:
3333:
3294:
3256:
3248:
3207:
3168:
3131:
3090:
3049:
3008:
3000:
2959:
2912:
2874:
2833:
2792:
2765:
2743:
2704:
2694:
2653:
2612:
2572:
2504:
2463:
2455:
2416:
2373:
2336:
612:
543:
487:
442:
4741:"Pathogenetic role of JAK2 V617F mutation in chronic myeloproliferative disorders"
3320:
Ogata N, Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K (April 1998).
2617:
2600:
2576:
347:
7460:
7437:
6982:
6899:
6662:
6316:
6300:
6213:
5533:
5523:
5518:
5498:
5493:
5488:
5483:
5478:
5469:
5204:
4723:
4673:
2658:
2641:
587:
371:
4558:
Matsuguchi T, Inhorn RC, Carlesso N, Xu G, Druker B, Griffin JD (January 1995).
4494:
4477:
3875:
3858:
3685:
Pollack BP, Kotenko SV, He W, Izotova LS, Barnoski BL, Pestka S (October 1999).
3460:
3443:
2310:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2292:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1086:
activation of cysteine-type endopeptidase activity involved in apoptotic process
7546:
7321:
7311:
7238:
6855:
6845:
6769:
6601:
6449:
6354:
6295:
6009:
5999:
5383:
5200:
4958:
4948:
2044:
2040:
688:
4624:
4173:
3816:
VanderKuur J, Allevato G, Billestrup N, Norstedt G, Carter-Su C (March 1995).
7556:
6889:
6672:
6591:
6259:
6218:
5445:
5306:
4860:
4535:
4518:
4453:
4436:
4322:
4305:
4223:
4206:
4048:
4031:
3703:
3686:
3419:
3402:
3338:
3321:
3095:
3078:
2964:
2947:
2838:
2821:
2032:
2020:
790:
4345:
Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O (May 2002).
3834:
3817:
3524:
Tauchi T, Damen JE, Toyama K, Feng GS, Broxmeyer HE, Krystal G (June 1996).
3212:
3195:
2377:
748:
626:
7495:
7475:
7394:
7384:
7326:
7273:
7203:
7102:
7046:
6733:
6723:
6713:
6616:
6596:
6561:
6556:
6208:
5990:
5701:
5692:
5436:
4982:
4940:
4766:
4731:
4702:
4681:
4642:
4412:
4395:
4380:
4331:
4232:
4191:
4092:
4075:
4005:
3966:
3925:
3916:
3899:
3802:
3793:
3776:
3743:
3712:
3671:
3663:
3618:
3579:
3501:
3484:
3469:
3379:
3306:
3298:
3270:
3180:
3172:
3004:
2973:
2888:
2847:
2806:
2797:
2780:
2757:
2716:
2667:
2626:
2477:
2428:
2385:
2341:
2324:
1887:
1386:
positive regulation of vascular associated smooth muscle cell proliferation
605:
384:
4593:
4544:
4503:
4478:"Induction of Jak/STAT signaling by activation of the type 1 TNF receptor"
4462:
4421:
4282:
4142:
4101:
4057:
4013:
3884:
3843:
3761:
3636:
3601:
Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T (December 1996).
3587:
3551:
3510:
3428:
3387:
3347:
3252:
3221:
3145:
3104:
3063:
3036:
Giorgetti-Peraldi S, Peyrade F, Baron V, Van
Obberghen E (December 1995).
3035:
3022:
2924:
2781:"hTid-1, a human DnaJ protein, modulates the interferon signaling pathway"
2584:
2518:
2350:
1863:
1858:
7505:
7500:
7404:
7389:
7361:
7351:
7346:
7301:
7268:
7263:
7258:
7253:
7248:
7233:
7228:
7051:
7036:
7031:
6850:
6835:
6652:
6432:
6367:
6203:
5101:
2708:
2699:
2682:
2491:
Neubauer H, Cumano A, Müller M, Wu H, Huffstadt U, Pfeffer K (May 1998).
2226:
1650:
1631:
30:
7341:
7243:
7097:
6642:
6115:
6110:
6100:
6095:
6086:
6035:
5951:
5841:
4517:
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997).
3859:"Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase"
3726:
Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C (November 1997).
2178:
1946:
1942:
1895:
504:
401:
351:
2748:
2731:
2459:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
7515:
7510:
7291:
6738:
6406:
6380:
2683:"A gain-of-function mutation of JAK2 in myeloproliferative disorders"
2200:
1966:
1505:
1031:
intrinsic apoptotic signaling pathway in response to oxidative stress
571:
558:
470:
457:
359:
3815:
7541:
6743:
5850:
5257:
4907:
2183:
2001:
1993:
1911:
1847:
4393:
4273:
4249:"A new protein containing an SH2 domain that inhibits JAK kinases"
4248:
4073:
2323:
Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA (June 1998).
5199:
4205:
Dif F, Saunier E, Demeneix B, Kelly PA, Edery M (December 2001).
3442:
Ryu H, Lee JH, Kim KS, Jeong SM, Kim PH, Chung HT (August 2000).
2820:
Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (June 1999).
1970:
1617:
1572:
1490:
1486:
1136:
positive regulation of nitric-oxide synthase biosynthetic process
4434:
4344:
4029:
1226:
positive regulation of DNA-binding transcription factor activity
1191:
positive regulation of growth hormone receptor signaling pathway
339:
7316:
7306:
6951:
6947:
6943:
6939:
6935:
6931:
6419:
6189:
6139:
5827:
5402:
5338:
5333:
4476:
Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB (March 1998).
3990:
3158:
3038:"Involvement of Janus kinases in the insulin signaling pathway"
2163:
2158:
2128:
2118:
2113:
2068:
2028:
1899:
1831:
1527:
1391:
positive regulation of tyrosine phosphorylation of STAT protein
4799:
4155:
1890:
family and has been implicated in signaling by members of the
1346:
positive regulation of phosphatidylinositol 3-kinase signaling
6986:
6927:
6923:
6919:
6915:
6911:
6907:
6804:
6393:
5927:
5805:
5770:
5765:
5741:
5543:
5528:
5513:
5508:
5503:
5455:
5450:
5426:
5421:
5412:
5324:
5319:
5296:
5267:
5262:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5048:
5043:
5038:
5033:
5015:
5010:
5005:
5000:
4995:
4990:
2986:
2204:
2153:
2143:
2133:
1923:
1915:
1903:
3938:
3897:
3856:
3283:
3193:
2901:
2553:
2322:
1231:
negative regulation of cardiac muscle cell apoptotic process
7371:
7283:
7220:
6045:
5975:
5922:
5913:
5874:
5865:
5855:
5736:
5727:
5717:
5663:
5654:
5639:
5630:
5620:
5615:
5591:
5392:
5244:
5221:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
4516:
4030:
Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998).
3117:
2680:
2193:
2188:
2148:
2123:
2098:
2088:
6158:
4606:
4557:
4245:
3234:
2441:
2363:
1296:
positive regulation of cytosolic calcium ion concentration
1061:
positive regulation of phosphoprotein phosphatase activity
950:
extrinsic component of cytoplasmic side of plasma membrane
6076:
6071:
6066:
6040:
4114:
3564:
3194:
Gual P, Baron V, Lequoy V, Van
Obberghen E (March 1998).
2860:
2819:
2083:
1321:
regulation of interferon-gamma-mediated signaling pathway
1181:
platelet-derived growth factor receptor signaling pathway
4709:
3725:
2861:
Huang LJ, Constantinescu SN, Lodish HF (December 2001).
1476:
positive regulation of MHC class II biosynthetic process
1366:
positive regulation of epithelial cell apoptotic process
1301:
positive regulation of nitric oxide biosynthetic process
1166:
positive regulation of peptidyl-tyrosine phosphorylation
595:
6612:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
4204:
3684:
3649:
2778:
2597:
1161:
positive regulation of tumor necrosis factor production
3600:
2490:
1451:
positive regulation of Ras protein signal transduction
1206:
growth hormone receptor signaling pathway via JAK-STAT
879:
non-membrane spanning protein tyrosine kinase activity
16:
Non-receptor tyrosine kinase and coding gene in humans
7530:
4688:
3523:
3319:
2945:
1441:
regulation of receptor signaling pathway via JAK-STAT
760:
4475:
4303:
3076:
2732:"The JAK2 exon 12 mutations: a comprehensive review"
2541:"OrthoMaM phylogenetic marker: JAK2 coding sequence"
1960:
Loss of JAK2 is lethal by embryonic day 12 in mice.
1331:
positive regulation of cell population proliferation
1091:
negative regulation of cell population proliferation
1071:
positive regulation of interleukin-1 beta production
4304:Pezet A, Favre H, Kelly PA, Edery M (August 1999).
3994:
3775:Xie S, Lin H, Sun T, Arlinghaus RB (October 2002).
3774:
3568:
3368:
3287:
2266:
2264:
2262:
2245:
2243:
2241:
1466:positive regulation of cold-induced thermogenesis
542:
441:
7554:
6704:Granulocyte macrophage colony-stimulating factor
6479:
3777:"Jak2 is involved in c-Myc induction by Bcr-Abl"
3483:Yin T, Shen R, Feng GS, Yang YC (January 1997).
1256:enzyme linked receptor protein signaling pathway
1051:tumor necrosis factor-mediated signaling pathway
3482:
2406:
2259:
2238:
1446:regulation of nitric oxide biosynthetic process
1026:negative regulation of neuron apoptotic process
4890:
4069:
4067:
4025:
4023:
3986:
3984:
3543:10.1182/blood.V87.11.4495.bloodjournal87114495
3441:
3361:
3359:
3357:
2271:GRCm38: Ensembl release 89: ENSMUSG00000024789
1973:for which complete genome data are available.
1186:positive regulation of cell-substrate adhesion
6465:
6174:
5185:
4876:
4815:
4689:Pargade V, Darnige L, Gaussem P (2006). "".
4600:
4338:
4297:
4198:
4149:
3932:
3891:
3768:
3678:
3643:
3435:
3277:
3228:
3152:
2939:
2854:
2813:
2772:
2723:
2674:
2639:
2633:
2591:
2000:genes have been found in patients suffering
1456:modulation of chemical synaptic transmission
1281:mineralocorticoid receptor signaling pathway
1211:positive regulation of inflammatory response
1196:G protein-coupled receptor signaling pathway
4551:
4510:
4469:
4428:
4387:
4239:
4108:
4064:
4032:"Jak2-Stat5 interactions analyzed in yeast"
4020:
3981:
3850:
3809:
3719:
3594:
3558:
3517:
3476:
3400:
3394:
3354:
3313:
3187:
3111:
3070:
3029:
2980:
2895:
2547:
2400:
2250:GRCh38: Ensembl release 89: ENSG00000096968
1326:regulation of cell population proliferation
1156:positive regulation of cell differentiation
1041:interferon-gamma-mediated signaling pathway
7471:Leukemia/leukocyte inhibitory factor (LIF)
6472:
6458:
6181:
6167:
5192:
5178:
4883:
4869:
4822:
4808:
4745:Journal of the Chinese Medical Association
3365:
2484:
2357:
2316:
2011:Mutations in JAK2 have been implicated in
7466:FMS-like tyrosine kinase 3 ligand (FLT3L)
6895:Interferon alpha (interferon alfa, IFN-α)
4792:at the U.S. National Library of Medicine
4756:
4632:
4583:
4534:
4493:
4452:
4411:
4370:
4321:
4272:
4222:
4181:
4132:
4091:
4047:
3956:
3915:
3874:
3833:
3792:
3751:
3702:
3626:
3541:
3500:
3459:
3418:
3337:
3260:
3211:
3135:
3094:
3053:
3012:
2963:
2878:
2837:
2796:
2747:
2698:
2657:
2616:
2508:
2467:
2448:Nature Structural & Molecular Biology
2340:
2039:more sensitive to growth factors such as
1431:interleukin-35-mediated signaling pathway
1426:interleukin-27-mediated signaling pathway
1416:interleukin-23-mediated signaling pathway
1406:interleukin-12-mediated signaling pathway
1276:negative regulation of cell-cell adhesion
1066:growth hormone receptor signaling pathway
844:histone kinase activity (H3-Y41 specific)
7488:Additional cytokine receptor modulators:
2533:
1976:
1922:), and the single chain receptors (e.g.
1461:postsynapse to nucleus signaling pathway
1421:interleukin-6-mediated signaling pathway
1401:tyrosine phosphorylation of STAT protein
1341:positive regulation of apoptotic process
1286:negative regulation of heart contraction
1261:positive regulation of insulin secretion
2035:at the 617 position, appears to render
1266:receptor signaling pathway via JAK-STAT
7555:
7312:Cucurbitacin I (elatericin B, JSI-124)
4659:
3401:Zhu T, Goh EL, Lobie PE (April 1998).
2203:signals through JAK2 are dependent on
1106:positive regulation of cell activation
6648:Granulocyte colony-stimulating factor
6453:
6162:
5826:
5220:
5173:
4864:
4803:
3652:Blood Cells, Molecules & Diseases
2729:
2642:"Myeloid neoplasms with eosinophilia"
2027:. This mutation (V617F), a change of
1291:positive regulation of cell migration
1251:peptidyl-tyrosine autophosphorylation
1116:extrinsic apoptotic signaling pathway
909:phosphatidylinositol 3-kinase binding
547:
508:
503:
446:
405:
400:
326:, JTK10, THCYT3, Janus kinase 2, MAX2
7007:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
6780:Macrophage colony-stimulating factor
4613:Molecular and Cellular Endocrinology
3241:The Journal of Experimental Medicine
2993:The Journal of Experimental Medicine
2421:10.1146/annurev.med.59.061506.154159
1111:mammary gland epithelium development
7481:Thymic stromal lymphopoietin (TSLP)
4738:
4523:The Journal of Biological Chemistry
4310:The Journal of Biological Chemistry
4036:The Journal of Biological Chemistry
3904:The Journal of Biological Chemistry
3822:The Journal of Biological Chemistry
3691:The Journal of Biological Chemistry
3489:The Journal of Biological Chemistry
3407:The Journal of Biological Chemistry
3124:The Journal of Biological Chemistry
3083:The Journal of Biological Chemistry
2952:The Journal of Biological Chemistry
2826:The Journal of Biological Chemistry
2785:The Journal of Biological Chemistry
2687:The New England Journal of Medicine
1411:cytokine-mediated signaling pathway
1396:activation of Janus kinase activity
1246:regulation of inflammatory response
899:type 1 angiotensin receptor binding
13:
4652:
4576:10.1002/j.1460-2075.1995.tb06999.x
1949:) and the presence of up to seven
1336:hormone-mediated signaling pathway
1076:positive regulation of DNA binding
1046:negative regulation of DNA binding
914:insulin receptor substrate binding
14:
7579:
4783:
3161:Growth Hormone & IGF Research
2223:, medical drugs under development
2059:Janus kinase 2 has been shown to
1381:negative regulation of cell death
1351:peptidyl-tyrosine phosphorylation
1271:intracellular signal transduction
1146:response to tumor necrosis factor
7540:
4840:
4363:10.1128/MCB.22.10.3316-3326.2002
3958:10.1046/j.1365-2443.1999.00263.x
3055:10.1111/j.1432-1033.1995.656_b.x
3042:European Journal of Biochemistry
919:peptide hormone receptor binding
864:protein tyrosine kinase activity
531:
524:
518:
495:
430:
423:
417:
392:
29:
7012:Interferon omega (IFN-ω, IFNW1)
4829:
2054:
1101:regulation of apoptotic process
829:interleukin-12 receptor binding
824:growth hormone receptor binding
4351:Molecular and Cellular Biology
3732:Molecular and Cellular Biology
3607:Molecular and Cellular Biology
2736:American Journal of Hematology
2435:
2298:
2280:
1241:response to lipopolysaccharide
904:acetylcholine receptor binding
749:More reference expression data
1:
5829:Non-receptor tyrosine kinases
4758:10.1016/S1726-4901(09)70337-5
4134:10.1016/S1074-7613(00)80288-5
3137:10.1016/S0021-9258(17)31863-X
2880:10.1016/S1097-2765(01)00401-4
2618:10.1158/0008-5472.CAN-04-4263
2577:10.1126/science.278.5341.1309
2510:10.1016/S0092-8674(00)81168-X
2232:
1236:actin filament polymerization
516:
415:
4724:10.1016/j.patbio.2006.06.003
4691:Annales de Biologie Clinique
4674:10.1016/j.patbio.2005.07.002
2917:10.1016/0092-8674(93)90414-L
2659:10.1182/blood-2016-10-695973
2025:myeloproliferative disorders
1969:have been identified in all
1884:non-receptor tyrosine kinase
1141:response to oxidative stress
7:
7563:Genes on human chromosome 9
6856:Thrombopoietin (THPO, MGDF)
6622:Pegol sihematide (EPO-018B)
6542:Carbamylated erythropoietin
6188:
4495:10.4049/jimmunol.160.6.2742
3876:10.4049/jimmunol.158.9.4097
3461:10.4049/jimmunol.165.4.2116
2640:Reiter A, Gotlib J (2017).
2214:
1176:protein autophosphorylation
1171:erythrocyte differentiation
10:
7584:
4892:JAK-STAT signaling pathway
2209:RUSH transcription factors
1471:microglial cell activation
1151:response to interleukin-12
894:protein C-terminus binding
814:signaling receptor binding
7450:
7428:
7405:Tofacitinib (tasocitinib)
7370:
7362:Tofacitinib (tasocitinib)
7282:
7269:Tofacitinib (tasocitinib)
7219:
7202:
7195:
7175:
7155:
7135:
7111:
7070:
6877:
6868:
6823:
6803:
6752:
6686:
6630:
6519:
6510:
6490:
6345:
6337:Michaelis–Menten kinetics
6309:
6278:
6247:
6196:
6124:
6085:
6054:
6023:
5989:
5960:
5936:
5912:
5888:
5864:
5840:
5836:
5822:
5798:
5779:
5750:
5726:
5710:
5691:
5672:
5653:
5629:
5605:
5581:
5557:
5468:
5435:
5411:
5382:
5348:
5305:
5276:
5243:
5234:
5230:
5223:Receptor tyrosine kinases
5216:
5110:
5057:
5024:
4981:
4972:
4939:
4931:Type II cytokine receptor
4916:
4898:
4835:
4660:Berger R (May 2006). "".
4625:10.1016/j.mce.2010.05.010
2409:Annual Review of Medicine
2306:"Mouse PubMed Reference:"
2288:"Human PubMed Reference:"
2017:essential thrombocythemia
1892:type II cytokine receptor
1862:
1857:
1853:
1846:
1830:
1811:
1792:
1788:
1767:
1743:
1736:
1717:
1713:
1692:
1668:
1661:
1648:
1644:
1629:
1625:
1616:
1603:
1599:
1584:
1580:
1571:
1558:
1554:
1539:
1535:
1526:
1511:
1504:
1500:
1484:
1311:response to hydroperoxide
884:identical protein binding
789:
785:
773:
768:
759:
746:
695:
686:
657:Descending thoracic aorta
633:
624:
594:
586:
582:
565:
552:
515:
494:
485:
481:
464:
451:
414:
391:
382:
378:
333:
330:
320:
313:
308:
73:
68:
51:
46:
41:
37:
28:
23:
7083:Interferon gamma (IFN-γ)
6229:Diffusion-limited enzyme
4926:Type I cytokine receptor
4794:Medical Subject Headings
4536:10.1074/jbc.272.22.14334
4454:10.1182/blood.V91.5.1496
4323:10.1074/jbc.274.35.24497
4224:10.1210/endo.142.12.8549
4049:10.1074/jbc.273.20.12567
3704:10.1074/jbc.274.44.31531
3420:10.1074/jbc.273.17.10682
3339:10.1182/blood.V91.7.2264
3096:10.1074/jbc.270.24.14776
2965:10.1074/jbc.274.46.33131
2839:10.1074/jbc.274.24.17209
2730:Scott LM (August 2011).
1886:. It is a member of the
1824:Chr 19: 29.23 – 29.29 Mb
1036:adaptive immune response
727:Rostral migratory stream
6983:Interferon beta (IFN-β)
5236:Growth factor receptors
4174:10.1093/emboj/18.5.1309
3835:10.1074/jbc.270.13.7587
3213:10.1210/endo.139.3.5829
2378:10.1126/science.1249783
1918:receptor family (e.g.,
1056:protein phosphorylation
889:protein kinase activity
7461:Cardiotrophin 1 (CT-1)
4413:10.1038/sj.onc.1201071
4093:10.1038/sj.onc.1200907
4006:10.1006/bbrc.1997.7484
3917:10.1074/jbc.M003456200
3794:10.1038/sj.onc.1205942
3744:10.1128/mcb.17.11.6633
3664:10.1006/bcmd.2000.0273
3619:10.1128/mcb.16.12.6985
3580:10.1006/bbrc.1996.1626
3502:10.1074/jbc.272.2.1032
3380:10.1006/bbrc.1996.1023
3299:10.1006/bbrc.1999.0479
3173:10.1054/ghir.1999.0111
3005:10.1084/jem.182.6.1801
2798:10.1074/jbc.M103683200
2342:10.1210/edrv.19.3.0334
2221:Janus kinase inhibitor
2008:forms of the disease.
1984:gene fusions with the
1436:chromatin organization
1376:innate immune response
1131:response to antibiotic
869:protein kinase binding
735:mesenteric lymph nodes
549:19 C1|19 23.73 cM
7458:Additional cytokines:
7385:Decernotinib (VX-509)
7022:Peginterferon alfa-2b
7017:Peginterferon alfa-2a
6537:Asialo erythropoietin
6322:Eadie–Hofstee diagram
6255:Allosteric regulation
4739:Hsu HC (March 2007).
4482:Journal of Immunology
3863:Journal of Immunology
3448:Journal of Immunology
3253:10.1084/jem.193.2.263
1977:Clinical significance
1817:Chr 9: 4.98 – 5.13 Mb
1221:immune system process
1010:glutamatergic synapse
510:Chromosome 19 (mouse)
6973:Interferon alfacon-1
6602:Erythropoietin (EPO)
6332:Lineweaver–Burk plot
5307:PDGF receptor family
2700:10.1056/NEJMoa051113
1951:JAK homology domains
1201:cell differentiation
1081:mesoderm development
849:transferase activity
673:left coronary artery
408:Chromosome 9 (human)
69:List of PDB id codes
42:Available structures
7120:See IL-28R (IFNLR)
7088:Interferon gamma 1b
6978:Interferon alpha-n3
5711:ROS receptor family
5245:EGF receptor family
4712:Pathologie-Biologie
4662:Pathologie-Biologie
4265:1997Natur.387..921E
2569:1997Sci...278.1309L
2037:hematopoietic cells
2006:clonal eosinophilia
1955:pseudokinase domain
1361:signal transduction
985:endomembrane system
7476:Oncostatin M (OSM)
7002:Interferon beta 1b
6997:Interferon beta 1a
6968:Interferon alfa n1
6963:Interferon alfa 2b
6958:Interferon alfa 2a
6792:Kinase inhibitors:
6291:Enzyme superfamily
6224:Enzyme promiscuity
1606:ENSMUSG00000024789
1019:Biological process
928:Cellular component
874:nucleotide binding
804:SH2 domain binding
797:Molecular function
7528:
7527:
7524:
7523:
7446:
7445:
7213:
7131:
7130:
6864:
6863:
6607:Erythropoietin-Fc
6481:Cytokine receptor
6447:
6446:
6156:
6155:
6152:
6151:
6148:
6147:
5818:
5817:
5814:
5813:
5464:
5463:
5167:
5166:
5163:
5162:
4918:Cytokine receptor
4858:
4857:
4316:(35): 24497–502.
2749:10.1002/ajh.22063
2563:(5341): 1309–12.
2460:10.1038/nsmb.2099
2372:(6185): 1249783.
2329:Endocrine Reviews
2049:polycythemia vera
2023:as well as other
2013:polycythemia vera
1902:receptor family (
1878:(commonly called
1873:
1872:
1869:
1868:
1842:
1841:
1807:
1806:
1782:
1781:
1732:
1731:
1707:
1706:
1657:
1656:
1638:
1637:
1612:
1611:
1593:
1592:
1567:
1566:
1548:
1547:
1496:
1495:
1306:blood coagulation
1121:axon regeneration
1096:apoptotic process
834:metal ion binding
781:
780:
777:
776:
755:
754:
742:
741:
680:
679:
578:
577:
477:
476:
304:
303:
300:
299:
52:Ortholog search:
7575:
7568:Tyrosine kinases
7545:
7544:
7536:
7217:
7216:
7207:
7200:
7199:
7059:Decoy receptors:
6875:
6874:
6552:Darbepoetin alfa
6517:
6516:
6474:
6467:
6460:
6451:
6450:
6327:Hanes–Woolf plot
6270:Enzyme activator
6265:Enzyme inhibitor
6239:Enzyme catalysis
6183:
6176:
6169:
6160:
6159:
5838:
5837:
5824:
5823:
5278:Insulin receptor
5241:
5240:
5232:
5231:
5218:
5217:
5205:tyrosine kinases
5194:
5187:
5180:
5171:
5170:
4979:
4978:
4974:Adaptor proteins
4885:
4878:
4871:
4862:
4861:
4844:
4824:
4817:
4810:
4801:
4800:
4778:
4760:
4735:
4706:
4685:
4647:
4646:
4636:
4604:
4598:
4597:
4587:
4555:
4549:
4548:
4538:
4529:(22): 14334–40.
4514:
4508:
4507:
4497:
4473:
4467:
4466:
4456:
4432:
4426:
4425:
4415:
4391:
4385:
4384:
4374:
4342:
4336:
4335:
4325:
4301:
4295:
4294:
4276:
4243:
4237:
4236:
4226:
4202:
4196:
4195:
4185:
4162:The EMBO Journal
4153:
4147:
4146:
4136:
4112:
4106:
4105:
4095:
4071:
4062:
4061:
4051:
4042:(20): 12567–75.
4027:
4018:
4017:
3988:
3979:
3978:
3960:
3936:
3930:
3929:
3919:
3910:(38): 29338–47.
3895:
3889:
3888:
3878:
3854:
3848:
3847:
3837:
3813:
3807:
3806:
3796:
3772:
3766:
3765:
3755:
3723:
3717:
3716:
3706:
3697:(44): 31531–42.
3682:
3676:
3675:
3647:
3641:
3640:
3630:
3598:
3592:
3591:
3562:
3556:
3555:
3545:
3536:(11): 4495–501.
3521:
3515:
3514:
3504:
3480:
3474:
3473:
3463:
3439:
3433:
3432:
3422:
3398:
3392:
3391:
3363:
3352:
3351:
3341:
3317:
3311:
3310:
3281:
3275:
3274:
3264:
3232:
3226:
3225:
3215:
3191:
3185:
3184:
3156:
3150:
3149:
3139:
3130:(34): 21709–17.
3115:
3109:
3108:
3098:
3089:(24): 14776–85.
3074:
3068:
3067:
3057:
3033:
3027:
3026:
3016:
2984:
2978:
2977:
2967:
2958:(46): 33131–42.
2943:
2937:
2936:
2899:
2893:
2892:
2882:
2858:
2852:
2851:
2841:
2832:(24): 17209–18.
2817:
2811:
2810:
2800:
2791:(52): 49034–42.
2776:
2770:
2769:
2751:
2727:
2721:
2720:
2702:
2678:
2672:
2671:
2661:
2637:
2631:
2630:
2620:
2595:
2589:
2588:
2551:
2545:
2544:
2537:
2531:
2530:
2512:
2488:
2482:
2481:
2471:
2439:
2433:
2432:
2404:
2398:
2397:
2361:
2355:
2354:
2344:
2320:
2314:
2313:
2302:
2296:
2295:
2284:
2278:
2268:
2257:
2247:
1898:receptors), the
1855:
1854:
1826:
1819:
1802:
1786:
1785:
1777:
1741:
1740:
1737:RefSeq (protein)
1727:
1711:
1710:
1702:
1666:
1665:
1642:
1641:
1623:
1622:
1597:
1596:
1578:
1577:
1552:
1551:
1533:
1532:
1502:
1501:
787:
786:
766:
765:
751:
703:secondary oocyte
691:
689:Top expressed in
684:
683:
645:popliteal artery
629:
627:Top expressed in
622:
621:
601:
600:
584:
583:
574:
561:
550:
535:
528:
522:
511:
499:
483:
482:
473:
460:
449:
434:
427:
421:
410:
396:
380:
379:
374:
372:JAK2 - orthologs
325:
318:
295:
66:
65:
60:
39:
38:
33:
21:
20:
7583:
7582:
7578:
7577:
7576:
7574:
7573:
7572:
7553:
7552:
7551:
7539:
7531:
7529:
7520:
7442:
7438:Deucravacitinib
7424:
7366:
7278:
7206:
7191:
7171:
7151:
7127:
7107:
7066:
6900:Interferon alfa
6860:
6819:
6799:
6748:
6682:
6678:Pegnartograstim
6663:Lipegfilgrastim
6626:
6572:Epoetin epsilon
6506:
6486:
6478:
6448:
6443:
6355:Oxidoreductases
6341:
6317:Enzyme kinetics
6305:
6301:List of enzymes
6274:
6243:
6214:Catalytic triad
6192:
6187:
6157:
6144:
6120:
6081:
6050:
6019:
5985:
5956:
5932:
5908:
5884:
5860:
5832:
5810:
5794:
5775:
5746:
5722:
5706:
5687:
5668:
5649:
5625:
5601:
5577:
5553:
5460:
5431:
5407:
5378:
5344:
5301:
5272:
5226:
5212:
5201:Protein kinases
5198:
5168:
5159:
5106:
5053:
5020:
4968:
4935:
4912:
4894:
4889:
4859:
4854:
4851:
4845:
4831:
4828:
4786:
4781:
4655:
4653:Further reading
4650:
4605:
4601:
4556:
4552:
4515:
4511:
4474:
4470:
4447:(5): 1496–507.
4433:
4429:
4406:(19): 2273–82.
4392:
4388:
4357:(10): 3316–26.
4343:
4339:
4302:
4298:
4259:(6636): 921–4.
4244:
4240:
4217:(12): 5286–93.
4203:
4199:
4154:
4150:
4113:
4109:
4072:
4065:
4028:
4021:
3989:
3982:
3937:
3933:
3896:
3892:
3869:(9): 4097–103.
3855:
3851:
3828:(13): 7587–93.
3814:
3810:
3787:(47): 7137–46.
3773:
3769:
3738:(11): 6633–44.
3724:
3720:
3683:
3679:
3648:
3644:
3613:(12): 6985–92.
3599:
3595:
3563:
3559:
3522:
3518:
3481:
3477:
3440:
3436:
3413:(17): 10682–9.
3399:
3395:
3364:
3355:
3318:
3314:
3282:
3278:
3233:
3229:
3192:
3188:
3157:
3153:
3116:
3112:
3075:
3071:
3034:
3030:
2985:
2981:
2944:
2940:
2900:
2896:
2859:
2855:
2818:
2814:
2777:
2773:
2728:
2724:
2693:(17): 1779–90.
2679:
2675:
2638:
2634:
2605:Cancer Research
2596:
2592:
2552:
2548:
2539:
2538:
2534:
2489:
2485:
2440:
2436:
2405:
2401:
2362:
2358:
2321:
2317:
2304:
2303:
2299:
2286:
2285:
2281:
2269:
2260:
2248:
2239:
2235:
2217:
2198:
2057:
2004:, particularly
1979:
1864:View/Edit Mouse
1859:View/Edit Human
1822:
1815:
1812:Location (UCSC)
1798:
1794:
1773:
1769:
1763:
1759:
1755:
1751:
1747:
1723:
1719:
1698:
1694:
1688:
1684:
1680:
1676:
1672:
1587:ENSG00000096968
1480:
1216:phosphorylation
1014:
995:plasma membrane
923:
859:protein binding
854:histone binding
809:kinase activity
747:
738:
733:
729:
725:
721:
717:
713:
709:
705:
701:
687:
676:
671:
667:
663:
661:ascending aorta
659:
655:
651:
649:tibial arteries
647:
643:
639:
637:Achilles tendon
625:
569:
556:
548:
538:
537:
536:
529:
509:
486:Gene location (
468:
455:
447:
437:
436:
435:
428:
406:
383:Gene location (
334:
321:
314:
75:
53:
17:
12:
11:
5:
7581:
7571:
7570:
7565:
7550:
7549:
7526:
7525:
7522:
7521:
7519:
7518:
7513:
7508:
7503:
7498:
7493:
7484:
7483:
7478:
7473:
7468:
7463:
7454:
7452:
7448:
7447:
7444:
7443:
7441:
7440:
7434:
7432:
7426:
7425:
7423:
7422:
7417:
7412:
7407:
7402:
7397:
7392:
7387:
7382:
7380:Cercosporamide
7376:
7374:
7368:
7367:
7365:
7364:
7359:
7354:
7349:
7344:
7339:
7334:
7329:
7324:
7322:Deuruxolitinib
7319:
7314:
7309:
7304:
7299:
7294:
7288:
7286:
7280:
7279:
7277:
7276:
7271:
7266:
7261:
7256:
7251:
7246:
7241:
7239:Deuruxolitinib
7236:
7231:
7225:
7223:
7214:
7197:
7193:
7192:
7190:
7189:
7181:
7179:
7173:
7172:
7170:
7169:
7161:
7159:
7153:
7152:
7150:
7149:
7141:
7139:
7133:
7132:
7129:
7128:
7126:
7125:
7117:
7115:
7113:IFNLR (λ, III)
7109:
7108:
7106:
7105:
7100:
7091:
7090:
7085:
7076:
7074:
7068:
7067:
7065:
7064:
7055:
7054:
7049:
7044:
7039:
7034:
7025:
7024:
7019:
7014:
7009:
7004:
6999:
6994:
6980:
6975:
6970:
6965:
6960:
6955:
6897:
6892:
6883:
6881:
6879:IFNAR (α/β, I)
6872:
6866:
6865:
6862:
6861:
6859:
6858:
6853:
6848:
6846:Promegapoietin
6843:
6838:
6829:
6827:
6825:Thrombopoietin
6821:
6820:
6818:
6817:
6809:
6807:
6801:
6800:
6798:
6797:
6788:
6787:
6782:
6777:
6772:
6770:Interleukin-34
6767:
6758:
6756:
6750:
6749:
6747:
6746:
6741:
6736:
6727:
6726:
6721:
6716:
6711:
6706:
6701:
6692:
6690:
6684:
6683:
6681:
6680:
6675:
6670:
6665:
6660:
6655:
6650:
6645:
6636:
6634:
6628:
6627:
6625:
6624:
6619:
6614:
6609:
6604:
6599:
6594:
6589:
6584:
6579:
6574:
6569:
6564:
6559:
6554:
6549:
6544:
6539:
6534:
6525:
6523:
6521:Erythropoietin
6514:
6508:
6507:
6505:
6504:
6496:
6494:
6488:
6487:
6477:
6476:
6469:
6462:
6454:
6445:
6444:
6442:
6441:
6428:
6415:
6402:
6389:
6376:
6363:
6349:
6347:
6343:
6342:
6340:
6339:
6334:
6329:
6324:
6319:
6313:
6311:
6307:
6306:
6304:
6303:
6298:
6293:
6288:
6282:
6280:
6279:Classification
6276:
6275:
6273:
6272:
6267:
6262:
6257:
6251:
6249:
6245:
6244:
6242:
6241:
6236:
6231:
6226:
6221:
6216:
6211:
6206:
6200:
6198:
6194:
6193:
6186:
6185:
6178:
6171:
6163:
6154:
6153:
6150:
6149:
6146:
6145:
6143:
6142:
6137:
6131:
6129:
6122:
6121:
6119:
6118:
6113:
6108:
6103:
6098:
6092:
6090:
6083:
6082:
6080:
6079:
6074:
6069:
6064:
6058:
6056:
6052:
6051:
6049:
6048:
6043:
6038:
6033:
6027:
6025:
6021:
6020:
6018:
6017:
6012:
6007:
6002:
5996:
5994:
5987:
5986:
5984:
5983:
5978:
5973:
5967:
5965:
5958:
5957:
5955:
5954:
5949:
5943:
5941:
5934:
5933:
5931:
5930:
5925:
5919:
5917:
5910:
5909:
5907:
5906:
5901:
5895:
5893:
5886:
5885:
5883:
5882:
5877:
5871:
5869:
5862:
5861:
5859:
5858:
5853:
5847:
5845:
5834:
5833:
5820:
5819:
5816:
5815:
5812:
5811:
5809:
5808:
5802:
5800:
5796:
5795:
5793:
5792:
5786:
5784:
5777:
5776:
5774:
5773:
5768:
5763:
5757:
5755:
5748:
5747:
5745:
5744:
5739:
5733:
5731:
5728:AATYK receptor
5724:
5723:
5721:
5720:
5714:
5712:
5708:
5707:
5705:
5704:
5698:
5696:
5689:
5688:
5686:
5685:
5679:
5677:
5670:
5669:
5667:
5666:
5660:
5658:
5651:
5650:
5648:
5647:
5642:
5636:
5634:
5627:
5626:
5624:
5623:
5618:
5612:
5610:
5603:
5602:
5600:
5599:
5594:
5588:
5586:
5579:
5578:
5576:
5575:
5570:
5564:
5562:
5555:
5554:
5552:
5551:
5546:
5541:
5536:
5531:
5526:
5521:
5516:
5511:
5506:
5501:
5496:
5491:
5486:
5481:
5475:
5473:
5466:
5465:
5462:
5461:
5459:
5458:
5453:
5448:
5442:
5440:
5433:
5432:
5430:
5429:
5424:
5418:
5416:
5409:
5408:
5406:
5405:
5400:
5395:
5389:
5387:
5384:VEGF receptors
5380:
5379:
5377:
5376:
5371:
5366:
5361:
5355:
5353:
5346:
5345:
5343:
5342:
5336:
5327:
5322:
5317:
5311:
5309:
5303:
5302:
5300:
5299:
5294:
5289:
5283:
5281:
5274:
5273:
5271:
5270:
5265:
5260:
5255:
5249:
5247:
5238:
5228:
5227:
5214:
5213:
5197:
5196:
5189:
5182:
5174:
5165:
5164:
5161:
5160:
5158:
5157:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5116:
5114:
5108:
5107:
5105:
5104:
5099:
5094:
5089:
5084:
5079:
5074:
5069:
5063:
5061:
5055:
5054:
5052:
5051:
5046:
5041:
5036:
5030:
5028:
5022:
5021:
5019:
5018:
5013:
5008:
5003:
4998:
4993:
4987:
4985:
4976:
4970:
4969:
4967:
4966:
4961:
4956:
4951:
4945:
4943:
4937:
4936:
4934:
4933:
4928:
4922:
4920:
4914:
4913:
4911:
4910:
4904:
4902:
4896:
4895:
4888:
4887:
4880:
4873:
4865:
4856:
4855:
4853:
4852:
4846:
4839:
4836:
4833:
4832:
4827:
4826:
4819:
4812:
4804:
4798:
4797:
4790:Janus+Kinase+2
4785:
4784:External links
4782:
4780:
4779:
4736:
4707:
4686:
4656:
4654:
4651:
4649:
4648:
4619:(1–2): 143–9.
4599:
4550:
4509:
4488:(6): 2742–50.
4468:
4427:
4386:
4337:
4296:
4238:
4197:
4168:(5): 1309–20.
4148:
4107:
4063:
4019:
3980:
3945:Genes to Cells
3931:
3890:
3849:
3808:
3767:
3718:
3677:
3642:
3593:
3557:
3516:
3475:
3454:(4): 2116–23.
3434:
3393:
3353:
3332:(7): 2264–71.
3312:
3276:
3227:
3186:
3151:
3110:
3069:
3028:
2979:
2938:
2894:
2873:(6): 1327–38.
2867:Molecular Cell
2853:
2812:
2771:
2722:
2673:
2652:(6): 704–714.
2632:
2590:
2546:
2532:
2503:(3): 397–409.
2483:
2454:(9): 971–976.
2434:
2399:
2356:
2315:
2297:
2279:
2258:
2236:
2234:
2231:
2230:
2229:
2224:
2216:
2213:
2197:
2196:
2191:
2186:
2181:
2176:
2171:
2166:
2161:
2156:
2151:
2146:
2141:
2136:
2131:
2126:
2121:
2116:
2111:
2106:
2101:
2096:
2091:
2086:
2081:
2076:
2071:
2065:
2056:
2053:
2045:thrombopoietin
2041:erythropoietin
1978:
1975:
1876:Janus kinase 2
1871:
1870:
1867:
1866:
1861:
1851:
1850:
1844:
1843:
1840:
1839:
1837:
1835:
1828:
1827:
1820:
1813:
1809:
1808:
1805:
1804:
1790:
1789:
1783:
1780:
1779:
1765:
1764:
1738:
1734:
1733:
1730:
1729:
1715:
1714:
1708:
1705:
1704:
1690:
1689:
1663:
1659:
1658:
1655:
1654:
1646:
1645:
1639:
1636:
1635:
1627:
1626:
1620:
1614:
1613:
1610:
1609:
1601:
1600:
1594:
1591:
1590:
1582:
1581:
1575:
1569:
1568:
1565:
1564:
1556:
1555:
1549:
1546:
1545:
1537:
1536:
1530:
1524:
1523:
1518:
1513:
1509:
1508:
1498:
1497:
1494:
1493:
1482:
1481:
1479:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1356:cell migration
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1022:
1020:
1016:
1015:
1013:
1012:
1007:
1002:
1000:focal adhesion
997:
992:
987:
982:
977:
975:endosome lumen
972:
970:nuclear matrix
967:
962:
957:
952:
947:
942:
937:
931:
929:
925:
924:
922:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
800:
798:
794:
793:
783:
782:
779:
778:
775:
774:
771:
770:
763:
757:
756:
753:
752:
744:
743:
740:
739:
737:
736:
732:
728:
724:
720:
716:
712:
708:
707:primary oocyte
704:
700:
696:
693:
692:
681:
678:
677:
675:
674:
670:
666:
662:
658:
654:
650:
646:
642:
638:
634:
631:
630:
618:
617:
609:
598:
592:
591:
588:RNA expression
580:
579:
576:
575:
567:
563:
562:
554:
551:
546:
540:
539:
530:
523:
517:
513:
512:
507:
501:
500:
492:
491:
479:
478:
475:
474:
466:
462:
461:
453:
450:
445:
439:
438:
429:
422:
416:
412:
411:
404:
398:
397:
389:
388:
376:
375:
332:
328:
327:
319:
311:
310:
306:
305:
302:
301:
298:
297:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
7580:
7569:
7566:
7564:
7561:
7560:
7558:
7548:
7543:
7538:
7537:
7534:
7517:
7514:
7512:
7509:
7507:
7504:
7502:
7499:
7497:
7494:
7492:
7489:
7486:
7485:
7482:
7479:
7477:
7474:
7472:
7469:
7467:
7464:
7462:
7459:
7456:
7455:
7453:
7449:
7439:
7436:
7435:
7433:
7431:
7427:
7421:
7418:
7416:
7413:
7411:
7408:
7406:
7403:
7401:
7398:
7396:
7393:
7391:
7388:
7386:
7383:
7381:
7378:
7377:
7375:
7373:
7369:
7363:
7360:
7358:
7355:
7353:
7350:
7348:
7345:
7343:
7340:
7338:
7335:
7333:
7330:
7328:
7325:
7323:
7320:
7318:
7315:
7313:
7310:
7308:
7305:
7303:
7300:
7298:
7295:
7293:
7290:
7289:
7287:
7285:
7281:
7275:
7272:
7270:
7267:
7265:
7262:
7260:
7257:
7255:
7252:
7250:
7247:
7245:
7242:
7240:
7237:
7235:
7232:
7230:
7227:
7226:
7224:
7222:
7218:
7215:
7211:
7205:
7201:
7198:
7194:
7187:
7183:
7182:
7180:
7178:
7174:
7167:
7163:
7162:
7160:
7158:
7154:
7147:
7143:
7142:
7140:
7138:
7134:
7123:
7119:
7118:
7116:
7114:
7110:
7104:
7101:
7099:
7096:
7093:
7092:
7089:
7086:
7084:
7081:
7078:
7077:
7075:
7073:
7072:IFNGR (γ, II)
7069:
7063:
7060:
7057:
7056:
7053:
7050:
7048:
7045:
7043:
7040:
7038:
7035:
7033:
7030:
7027:
7026:
7023:
7020:
7018:
7015:
7013:
7010:
7008:
7005:
7003:
7000:
6998:
6995:
6992:
6988:
6984:
6981:
6979:
6976:
6974:
6971:
6969:
6966:
6964:
6961:
6959:
6956:
6953:
6949:
6945:
6941:
6937:
6933:
6929:
6925:
6921:
6917:
6913:
6909:
6905:
6901:
6898:
6896:
6893:
6891:
6890:Albinterferon
6888:
6885:
6884:
6882:
6880:
6876:
6873:
6871:
6867:
6857:
6854:
6852:
6849:
6847:
6844:
6842:
6839:
6837:
6834:
6831:
6830:
6828:
6826:
6822:
6815:
6811:
6810:
6808:
6806:
6802:
6796:
6793:
6790:
6789:
6786:
6783:
6781:
6778:
6776:
6773:
6771:
6768:
6766:
6763:
6760:
6759:
6757:
6755:
6751:
6745:
6742:
6740:
6737:
6735:
6732:
6729:
6728:
6725:
6722:
6720:
6717:
6715:
6712:
6710:
6707:
6705:
6702:
6700:
6697:
6694:
6693:
6691:
6689:
6688:GM-CSF (CSF2)
6685:
6679:
6676:
6674:
6673:Pegfilgrastim
6671:
6669:
6666:
6664:
6661:
6659:
6656:
6654:
6651:
6649:
6646:
6644:
6641:
6638:
6637:
6635:
6633:
6629:
6623:
6620:
6618:
6615:
6613:
6610:
6608:
6605:
6603:
6600:
6598:
6595:
6593:
6592:Epoetin theta
6590:
6588:
6587:Epoetin omega
6585:
6583:
6582:Epoetin kappa
6580:
6578:
6577:Epoetin gamma
6575:
6573:
6570:
6568:
6567:Epoetin delta
6565:
6563:
6560:
6558:
6555:
6553:
6550:
6548:
6545:
6543:
6540:
6538:
6535:
6533:
6530:
6527:
6526:
6524:
6522:
6518:
6515:
6513:
6509:
6502:
6498:
6497:
6495:
6493:
6489:
6485:
6482:
6475:
6470:
6468:
6463:
6461:
6456:
6455:
6452:
6439:
6435:
6434:
6429:
6426:
6422:
6421:
6416:
6413:
6409:
6408:
6403:
6400:
6396:
6395:
6390:
6387:
6383:
6382:
6377:
6374:
6370:
6369:
6364:
6361:
6357:
6356:
6351:
6350:
6348:
6344:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6318:
6315:
6314:
6312:
6308:
6302:
6299:
6297:
6296:Enzyme family
6294:
6292:
6289:
6287:
6284:
6283:
6281:
6277:
6271:
6268:
6266:
6263:
6261:
6260:Cooperativity
6258:
6256:
6253:
6252:
6250:
6246:
6240:
6237:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6219:Oxyanion hole
6217:
6215:
6212:
6210:
6207:
6205:
6202:
6201:
6199:
6195:
6191:
6184:
6179:
6177:
6172:
6170:
6165:
6164:
6161:
6141:
6138:
6136:
6133:
6132:
6130:
6127:
6123:
6117:
6114:
6112:
6109:
6107:
6104:
6102:
6099:
6097:
6094:
6093:
6091:
6088:
6084:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6059:
6057:
6053:
6047:
6044:
6042:
6039:
6037:
6034:
6032:
6029:
6028:
6026:
6022:
6016:
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5997:
5995:
5992:
5988:
5982:
5979:
5977:
5974:
5972:
5969:
5968:
5966:
5963:
5959:
5953:
5950:
5948:
5945:
5944:
5942:
5939:
5935:
5929:
5926:
5924:
5921:
5920:
5918:
5915:
5911:
5905:
5902:
5900:
5897:
5896:
5894:
5891:
5887:
5881:
5878:
5876:
5873:
5872:
5870:
5867:
5863:
5857:
5854:
5852:
5849:
5848:
5846:
5843:
5839:
5835:
5831:(EC 2.7.10.2)
5830:
5825:
5821:
5807:
5804:
5803:
5801:
5799:uncategorised
5797:
5791:
5788:
5787:
5785:
5782:
5778:
5772:
5769:
5767:
5764:
5762:
5759:
5758:
5756:
5753:
5749:
5743:
5740:
5738:
5735:
5734:
5732:
5729:
5725:
5719:
5716:
5715:
5713:
5709:
5703:
5700:
5699:
5697:
5694:
5693:MuSK receptor
5690:
5684:
5681:
5680:
5678:
5675:
5671:
5665:
5662:
5661:
5659:
5656:
5655:PTK7 receptor
5652:
5646:
5643:
5641:
5638:
5637:
5635:
5632:
5628:
5622:
5619:
5617:
5614:
5613:
5611:
5608:
5604:
5598:
5595:
5593:
5590:
5589:
5587:
5584:
5580:
5574:
5571:
5569:
5566:
5565:
5563:
5560:
5556:
5550:
5547:
5545:
5542:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5520:
5517:
5515:
5512:
5510:
5507:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5480:
5477:
5476:
5474:
5471:
5467:
5457:
5454:
5452:
5449:
5447:
5444:
5443:
5441:
5438:
5434:
5428:
5425:
5423:
5420:
5419:
5417:
5414:
5410:
5404:
5401:
5399:
5396:
5394:
5391:
5390:
5388:
5385:
5381:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5356:
5354:
5351:
5347:
5340:
5337:
5335:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5312:
5310:
5308:
5304:
5298:
5295:
5293:
5290:
5288:
5285:
5284:
5282:
5279:
5275:
5269:
5266:
5264:
5261:
5259:
5256:
5254:
5251:
5250:
5248:
5246:
5242:
5239:
5237:
5233:
5229:
5225:(EC 2.7.10.1)
5224:
5219:
5215:
5210:
5206:
5202:
5195:
5190:
5188:
5183:
5181:
5176:
5175:
5172:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5117:
5115:
5113:
5109:
5103:
5100:
5098:
5095:
5093:
5090:
5088:
5085:
5083:
5080:
5078:
5075:
5073:
5070:
5068:
5065:
5064:
5062:
5060:
5056:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5031:
5029:
5027:
5023:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4988:
4986:
4984:
4980:
4977:
4975:
4971:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4946:
4944:
4942:
4938:
4932:
4929:
4927:
4924:
4923:
4921:
4919:
4915:
4909:
4906:
4905:
4903:
4901:
4897:
4893:
4886:
4881:
4879:
4874:
4872:
4867:
4866:
4863:
4849:
4843:
4838:
4837:
4834:
4825:
4820:
4818:
4813:
4811:
4806:
4805:
4802:
4795:
4791:
4788:
4787:
4776:
4772:
4768:
4764:
4759:
4754:
4750:
4746:
4742:
4737:
4733:
4729:
4725:
4721:
4717:
4713:
4708:
4704:
4700:
4696:
4692:
4687:
4683:
4679:
4675:
4671:
4667:
4663:
4658:
4657:
4644:
4640:
4635:
4630:
4626:
4622:
4618:
4614:
4610:
4603:
4595:
4591:
4586:
4581:
4577:
4573:
4570:(2): 257–65.
4569:
4565:
4561:
4554:
4546:
4542:
4537:
4532:
4528:
4524:
4520:
4513:
4505:
4501:
4496:
4491:
4487:
4483:
4479:
4472:
4464:
4460:
4455:
4450:
4446:
4442:
4438:
4431:
4423:
4419:
4414:
4409:
4405:
4401:
4397:
4390:
4382:
4378:
4373:
4368:
4364:
4360:
4356:
4352:
4348:
4341:
4333:
4329:
4324:
4319:
4315:
4311:
4307:
4300:
4292:
4288:
4284:
4280:
4275:
4274:10.1038/43213
4270:
4266:
4262:
4258:
4254:
4250:
4242:
4234:
4230:
4225:
4220:
4216:
4212:
4211:Endocrinology
4208:
4201:
4193:
4189:
4184:
4179:
4175:
4171:
4167:
4163:
4159:
4152:
4144:
4140:
4135:
4130:
4127:(4): 449–57.
4126:
4122:
4118:
4111:
4103:
4099:
4094:
4089:
4086:(7): 751–61.
4085:
4081:
4077:
4070:
4068:
4059:
4055:
4050:
4045:
4041:
4037:
4033:
4026:
4024:
4015:
4011:
4007:
4003:
4000:(2): 439–46.
3999:
3995:
3987:
3985:
3976:
3972:
3968:
3964:
3959:
3954:
3951:(6): 339–51.
3950:
3946:
3942:
3935:
3927:
3923:
3918:
3913:
3909:
3905:
3901:
3894:
3886:
3882:
3877:
3872:
3868:
3864:
3860:
3853:
3845:
3841:
3836:
3831:
3827:
3823:
3819:
3812:
3804:
3800:
3795:
3790:
3786:
3782:
3778:
3771:
3763:
3759:
3754:
3749:
3745:
3741:
3737:
3733:
3729:
3722:
3714:
3710:
3705:
3700:
3696:
3692:
3688:
3681:
3673:
3669:
3665:
3661:
3657:
3653:
3646:
3638:
3634:
3629:
3624:
3620:
3616:
3612:
3608:
3604:
3597:
3589:
3585:
3581:
3577:
3573:
3569:
3561:
3553:
3549:
3544:
3539:
3535:
3531:
3527:
3520:
3512:
3508:
3503:
3498:
3495:(2): 1032–7.
3494:
3490:
3486:
3479:
3471:
3467:
3462:
3457:
3453:
3449:
3445:
3438:
3430:
3426:
3421:
3416:
3412:
3408:
3404:
3397:
3389:
3385:
3381:
3377:
3374:(2): 289–96.
3373:
3369:
3362:
3360:
3358:
3349:
3345:
3340:
3335:
3331:
3327:
3323:
3316:
3308:
3304:
3300:
3296:
3292:
3288:
3280:
3272:
3268:
3263:
3258:
3254:
3250:
3246:
3242:
3238:
3231:
3223:
3219:
3214:
3209:
3206:(3): 884–93.
3205:
3201:
3200:Endocrinology
3197:
3190:
3182:
3178:
3174:
3170:
3166:
3162:
3155:
3147:
3143:
3138:
3133:
3129:
3125:
3121:
3114:
3106:
3102:
3097:
3092:
3088:
3084:
3080:
3073:
3065:
3061:
3056:
3051:
3048:(2): 656–60.
3047:
3043:
3039:
3032:
3024:
3020:
3015:
3010:
3006:
3002:
2999:(6): 1801–6.
2998:
2994:
2990:
2983:
2975:
2971:
2966:
2961:
2957:
2953:
2949:
2942:
2934:
2930:
2926:
2922:
2918:
2914:
2911:(2): 227–36.
2910:
2906:
2898:
2890:
2886:
2881:
2876:
2872:
2868:
2864:
2857:
2849:
2845:
2840:
2835:
2831:
2827:
2823:
2816:
2808:
2804:
2799:
2794:
2790:
2786:
2782:
2775:
2767:
2763:
2759:
2755:
2750:
2745:
2742:(8): 668–76.
2741:
2737:
2733:
2726:
2718:
2714:
2710:
2709:11383/2023329
2706:
2701:
2696:
2692:
2688:
2684:
2677:
2669:
2665:
2660:
2655:
2651:
2647:
2643:
2636:
2628:
2624:
2619:
2614:
2611:(7): 2662–7.
2610:
2606:
2602:
2594:
2586:
2582:
2578:
2574:
2570:
2566:
2562:
2558:
2550:
2542:
2536:
2528:
2524:
2520:
2516:
2511:
2506:
2502:
2498:
2494:
2487:
2479:
2475:
2470:
2465:
2461:
2457:
2453:
2449:
2445:
2438:
2430:
2426:
2422:
2418:
2415:(1): 213–22.
2414:
2410:
2403:
2395:
2391:
2387:
2383:
2379:
2375:
2371:
2367:
2360:
2352:
2348:
2343:
2338:
2335:(3): 225–68.
2334:
2330:
2326:
2319:
2311:
2307:
2301:
2293:
2289:
2283:
2276:
2272:
2267:
2265:
2263:
2255:
2251:
2246:
2244:
2242:
2237:
2228:
2225:
2222:
2219:
2218:
2212:
2210:
2207:, and on the
2206:
2202:
2195:
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2175:
2172:
2170:
2167:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2132:
2130:
2127:
2125:
2122:
2120:
2117:
2115:
2112:
2110:
2107:
2105:
2102:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2075:
2072:
2070:
2067:
2066:
2064:
2062:
2052:
2050:
2046:
2042:
2038:
2034:
2033:phenylalanine
2030:
2026:
2022:
2021:myelofibrosis
2018:
2014:
2009:
2007:
2003:
1999:
1995:
1991:
1987:
1983:
1974:
1972:
1968:
1965:
1961:
1958:
1956:
1952:
1948:
1944:
1939:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1909:
1905:
1901:
1897:
1894:family (e.g.
1893:
1889:
1885:
1881:
1877:
1865:
1860:
1856:
1852:
1849:
1845:
1838:
1836:
1833:
1829:
1825:
1821:
1818:
1814:
1810:
1803:
1801:
1797:
1791:
1787:
1784:
1778:
1776:
1772:
1766:
1762:
1758:
1754:
1750:
1746:
1742:
1739:
1735:
1728:
1726:
1722:
1716:
1712:
1709:
1703:
1701:
1697:
1691:
1687:
1683:
1679:
1675:
1671:
1667:
1664:
1662:RefSeq (mRNA)
1660:
1653:
1652:
1647:
1643:
1640:
1634:
1633:
1628:
1624:
1621:
1619:
1615:
1608:
1607:
1602:
1598:
1595:
1589:
1588:
1583:
1579:
1576:
1574:
1570:
1563:
1562:
1557:
1553:
1550:
1544:
1543:
1538:
1534:
1531:
1529:
1525:
1522:
1519:
1517:
1514:
1510:
1507:
1503:
1499:
1492:
1488:
1483:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1404:
1402:
1399:
1397:
1394:
1392:
1389:
1387:
1384:
1382:
1379:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1023:
1021:
1018:
1017:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
980:membrane raft
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
932:
930:
927:
926:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
801:
799:
796:
795:
792:
791:Gene ontology
788:
784:
772:
767:
764:
762:
758:
750:
745:
734:
730:
726:
722:
718:
714:
710:
706:
702:
698:
697:
694:
690:
685:
682:
672:
668:
664:
660:
656:
652:
648:
644:
640:
636:
635:
632:
628:
623:
620:
619:
616:
614:
610:
608:
607:
603:
602:
599:
597:
593:
589:
585:
581:
573:
568:
564:
560:
555:
545:
541:
534:
527:
521:
514:
506:
502:
498:
493:
489:
484:
480:
472:
467:
463:
459:
454:
444:
440:
433:
426:
420:
413:
409:
403:
399:
395:
390:
386:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
329:
324:
317:
312:
307:
296:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
7496:Lestaurtinib
7487:
7457:
7395:Ritlecitinib
7327:Lestaurtinib
7274:Upadacitinib
7103:Fontolizumab
7094:
7079:
7058:
7047:Rontalizumab
7028:
6886:
6841:Pegacaristim
6832:
6791:
6761:
6754:M-CSF (CSF1)
6734:Mavrilimumab
6730:
6724:Sargramostim
6714:Molgramostim
6699:Ecogramostim
6695:
6668:Nartograstim
6639:
6632:G-CSF (CSF3)
6617:Peginesatide
6597:Epoetin zeta
6562:Epoetin beta
6557:Epoetin alfa
6528:
6433:Translocases
6430:
6417:
6404:
6391:
6378:
6368:Transferases
6365:
6352:
6209:Binding site
6055:SRC-B family
6024:SRC-A family
6004:
5781:RET receptor
5752:AXL receptor
5674:RYK receptor
5631:DDR receptor
5607:ROR receptor
5583:TIE receptor
5559:LTK receptor
5470:EPH receptor
5437:Trk receptor
5413:HGF receptor
5350:FGF receptor
4953:
4941:Janus kinase
4847:
4751:(3): 89–93.
4748:
4744:
4718:(2): 88–91.
4715:
4711:
4694:
4690:
4668:(4): 182–4.
4665:
4661:
4616:
4612:
4602:
4567:
4563:
4553:
4526:
4522:
4512:
4485:
4481:
4471:
4444:
4440:
4430:
4403:
4399:
4389:
4354:
4350:
4340:
4313:
4309:
4299:
4256:
4252:
4241:
4214:
4210:
4200:
4165:
4161:
4151:
4124:
4120:
4110:
4083:
4079:
4039:
4035:
3997:
3993:
3948:
3944:
3934:
3907:
3903:
3893:
3866:
3862:
3852:
3825:
3821:
3811:
3784:
3780:
3770:
3735:
3731:
3721:
3694:
3690:
3680:
3658:(1): 15–24.
3655:
3651:
3645:
3610:
3606:
3596:
3574:(1): 122–7.
3571:
3567:
3560:
3533:
3529:
3519:
3492:
3488:
3478:
3451:
3447:
3437:
3410:
3406:
3396:
3371:
3367:
3329:
3325:
3315:
3293:(2): 400–4.
3290:
3286:
3279:
3247:(2): 263–9.
3244:
3240:
3230:
3203:
3199:
3189:
3167:(3): 212–8.
3164:
3160:
3154:
3127:
3123:
3113:
3086:
3082:
3072:
3045:
3041:
3031:
2996:
2992:
2982:
2955:
2951:
2941:
2908:
2904:
2897:
2870:
2866:
2856:
2829:
2825:
2815:
2788:
2784:
2774:
2739:
2735:
2725:
2690:
2686:
2676:
2649:
2645:
2635:
2608:
2604:
2593:
2560:
2556:
2549:
2535:
2500:
2496:
2486:
2451:
2447:
2437:
2412:
2408:
2402:
2369:
2365:
2359:
2332:
2328:
2318:
2309:
2300:
2291:
2282:
2199:
2058:
2055:Interactions
2010:
1997:
1989:
1985:
1981:
1980:
1963:
1962:
1959:
1940:
1888:Janus kinase
1879:
1875:
1874:
1796:NP_001041642
1793:
1771:NP_001309133
1768:
1761:NP_001309128
1757:NP_001309127
1753:NP_001309125
1749:NP_001309124
1745:NP_001309123
1721:NM_001048177
1718:
1700:NM_001322204
1696:NM_001322199
1693:
1686:NM_001322198
1682:NM_001322196
1678:NM_001322195
1674:NM_001322194
1649:
1630:
1604:
1585:
1559:
1540:
1520:
1515:
1316:MAPK cascade
960:cytoskeleton
839:heme binding
611:
604:
331:External IDs
74:
18:
7506:Quizartinib
7501:Midostaurin
7390:Peficitinib
7352:Ruxolitinib
7347:Peficitinib
7302:Baricitinib
7264:Ruxolitinib
7259:Peficitinib
7254:Oclacitinib
7249:Momelotinib
7234:Baricitinib
7229:Abrocitinib
7137:Interleukin
7095:Antibodies:
7052:Sifalimumab
7037:Faralimomab
7032:Anifrolumab
7029:Antibodies:
6851:Romiplostim
6836:Eltrombopag
6805:SCF (c-Kit)
6731:Antibodies:
6719:Regramostim
6653:Lenograstim
6204:Active site
4830:PDB gallery
2227:Ruxolitinib
1005:postsynapse
990:nucleoplasm
819:ATP binding
715:Paneth cell
665:sural nerve
570:29,290,480
557:29,229,228
309:Identifiers
7557:Categories
7491:Emfilermin
7342:Pacritinib
7244:Filgotinib
7210:inhibitors
7098:Emapalumab
6870:Interferon
6795:Agerafenib
6785:Mirimostim
6775:Lanimostim
6709:Milodistim
6658:Leridistim
6643:Filgrastim
6484:modulators
6407:Isomerases
6381:Hydrolases
6248:Regulation
4697:(1): 3–9.
2277:, May 2017
2256:, May 2017
2233:References
1896:interferon
615:(ortholog)
469:5,129,948
456:4,984,390
352:HomoloGene
7516:Sunitinib
7511:Sorafenib
7420:ZM-449829
7410:WHI-P 154
7400:TCS-21311
7337:NSC-33994
7292:Atiprimod
7080:Agonists:
7062:Bifarcept
6887:Agonists:
6833:Agonists:
6765:Cilmostim
6762:Agonists:
6739:Namilumab
6696:Agonists:
6640:Agonists:
6529:Agonists:
6492:Chemokine
6286:EC number
2201:Prolactin
1967:orthologs
1800:NP_032439
1775:NP_004963
1725:NM_008413
1670:NM_004972
1506:Orthologs
935:cytoplasm
360:GeneCards
7415:ZM-39923
7332:NSC-7908
7297:AZD-1480
7188:instead.
7168:instead.
7148:instead.
7124:instead.
7042:MEDI-545
6816:instead.
6744:Otilimab
6547:CNTO-530
6503:instead.
6310:Kinetics
6234:Cofactor
6197:Activity
4908:Cytokine
4775:33300937
4767:17389152
4732:16904848
4703:16420986
4682:16084028
4643:20562009
4400:Oncogene
4381:11971965
4332:10455112
4233:11713228
4192:10064597
4121:Immunity
4080:Oncogene
3975:24871585
3967:10421843
3926:10882725
3803:12370803
3781:Oncogene
3713:10531356
3672:10772872
3470:10925297
3307:10198225
3271:11208867
3181:10502458
2974:10551884
2933:37503350
2889:11779507
2848:10358079
2807:11679576
2758:21674578
2717:15858187
2668:28028030
2627:15805263
2527:11375232
2478:21841788
2429:17919086
2394:27946074
2386:24833397
2273:–
2252:–
2215:See also
2184:TNFRSF1A
2061:interact
2002:leukemia
1994:TEL-JAK2
1912:GM-CSF-R
1848:Wikidata
1485:Sources:
945:membrane
641:monocyte
7547:Biology
7357:SD-1008
6532:ARA-290
6420:Ligases
6190:Enzymes
5211:2.7.10)
4634:2902710
4594:7530656
4545:9162069
4504:9510175
4463:9473212
4422:9178903
4291:4347361
4283:9202126
4261:Bibcode
4183:1171221
4143:9133424
4102:9047382
4058:9575217
4014:9344848
3885:9126968
3844:7535773
3762:9343427
3637:8943354
3588:8912646
3552:8639815
3511:8995399
3429:9553131
3388:8702385
3348:9516124
3262:2193341
3222:9492017
3146:8063815
3105:7540178
3064:8536716
3023:7500025
3014:2192257
2925:8343951
2766:2905512
2585:9360930
2565:Bibcode
2557:Science
2519:9590174
2469:4504201
2366:Science
2351:9626554
2275:Ensembl
2254:Ensembl
2104:IL12RB2
1971:mammals
1914:), the
1882:) is a
1618:UniProt
1573:Ensembl
1512:Species
1491:QuickGO
965:nucleus
955:caveola
940:cytosol
719:jejunum
590:pattern
316:Aliases
7533:Portal
7451:Others
7317:CYT387
7307:CHZ868
7196:Others
6952:IFNA21
6948:IFNA17
6944:IFNA16
6940:IFNA14
6936:IFNA13
6932:IFNA10
6394:Lyases
6128:family
6089:family
5993:family
5964:family
5940:family
5916:family
5892:family
5868:family
5844:family
5783:family
5754:family
5742:AATYK2
5730:family
5695:family
5676:family
5657:family
5633:family
5609:family
5585:family
5561:family
5472:family
5439:family
5415:family
5403:VEGFR3
5398:VEGFR2
5393:VEGFR1
5386:family
5352:family
5339:PDGFRB
5334:PDGFRA
5280:family
4900:Ligand
4796:(MeSH)
4773:
4765:
4730:
4701:
4680:
4641:
4631:
4592:
4585:398079
4582:
4564:EMBO J
4543:
4502:
4461:
4420:
4379:
4372:133778
4369:
4330:
4289:
4281:
4253:Nature
4231:
4190:
4180:
4141:
4100:
4056:
4012:
3973:
3965:
3924:
3883:
3842:
3801:
3760:
3753:232517
3750:
3711:
3670:
3635:
3628:231702
3625:
3586:
3550:
3509:
3468:
3427:
3386:
3346:
3305:
3269:
3259:
3220:
3179:
3144:
3103:
3062:
3021:
3011:
2972:
2931:
2923:
2887:
2846:
2805:
2764:
2756:
2715:
2666:
2625:
2583:
2525:
2517:
2476:
2466:
2427:
2392:
2384:
2349:
2164:STAT5B
2159:STAT5A
2129:PTPN11
2119:PPP2R4
2114:PIK3R1
2069:DNAJA3
2063:with:
2029:valine
2019:, and
1996:) and
1900:GM-CSF
1834:search
1832:PubMed
1651:Q62120
1632:O60674
1528:Entrez
761:BioGPS
723:uterus
699:zygote
653:glutes
448:9p24.1
340:147796
6991:IFNB3
6987:IFNB1
6928:IFNA8
6924:IFNA7
6920:IFNA6
6916:IFNA5
6912:IFNA4
6908:IFNA2
6904:IFNA1
6346:Types
6140:ZAP70
5806:STYK1
5771:TYRO3
5737:AATYK
5544:EPHB6
5539:EPHB5
5534:EPHB4
5529:EPHB3
5524:EPHB2
5519:EPHB1
5514:EPHA8
5509:EPHA7
5504:EPHA6
5499:EPHA5
5494:EPHA4
5489:EPHA3
5484:EPHA2
5479:EPHA1
5456:NTRK3
5451:NTRK2
5446:NTRK1
5374:FGFR4
5369:FGFR3
5364:FGFR2
5359:FGFR1
5330:PDGFR
5315:CSF1R
5297:INSRR
5287:IGF1R
5268:ERBB4
5263:ERBB3
5258:ERBB2
5049:PIAS4
5044:PIAS3
5039:PIAS2
5034:PIAS1
5016:STAT6
5011:STAT5
5006:STAT4
5001:STAT3
4996:STAT2
4991:STAT1
4771:S2CID
4441:Blood
4287:S2CID
3971:S2CID
3530:Blood
3326:Blood
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