190:
165:
374:
196:
891:
localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide chain. IL-3 is produced as a monomer
1671:
Takai S, Yamada K, Hirayama N, Miyajima A, Taniyama T (February 1994). "Mapping of the human gene encoding the mutual signal-transducing subunit (?-chain) of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) receptor complexes to chromosome
1143:. Interleukin 3 was originally discovered in mice and later isolated from humans. The cytokine was originally discovered via the observation that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3).
52:
1285:
Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (October 1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3".
2331:
Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3".
2422:
Dorssers L, Burger H, Bot F, Delwel R, Geurts van Kessel AH, Löwenberg B, Wagemaker G (1987). "Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3".
1405:
Aglietta M, Pasquino P, Sanavio F, Stacchini A, Severino A, Fubini L, Morelli S, Volta C, Monteverde A (1996-01-01). "Granulocyte-Macrophage colony stimulating factor and interleukin 3: Target cells and kinetics of response in vivo".
1088:
IL-3 is a T cell-derived, pluripotent and hematopoietic factor required for survival and proliferation of hematopoietic progenitor cells. The signal transmission is ensured by high affinity between cell surface
203:
977:
IL-3 also induces various effector functions in both immature and mature cells that more precisely modulate the body’s defense against microbial pathogens. IL-3 is also involved in the reconstruction of
1158:
However, it was observed that IL-3 is present in the myelomonocytic leukaemia cell line WEHI-3B. It is thought that this genetic change is the key in development of this leukemia type.
2052:"Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF"
2577:"Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding"
2003:"Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding"
1166:
Human IL-3 was first cloned in 1986 and since then clinical trials are ongoing. Post-chemotherapy, IL-3 application reduces chemotherapy delays and promotes regeneration of
2243:
Urdal DL, Price V, Sassenfeld HM, Cosman D, Gillis S, Park LS (1989). "Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3".
2206:
Kitamura T, Sato N, Arai K, Miyajima A (1991). "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors".
4169:
1094:
974:
populations. IL-3 signaling is able to give rise to widest array of cell lineages which is why it has been independently named “multi-CSF” in some older literature.
1755:"Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine"
4785:
1884:
Serrano F, Varas F, Bernard A, Bueren JA (1994). "Accelerated and longterm hematopoietic engraftment in mice transplanted with ex-vivo expanded bone marrow".
4045:
1093:
and IL-3. This high affinity receptor contains α and β subunits. IL-3 shares the β subunit with IL-5 and granulocyte-macrophage colony-stimulating factor (
4295:
940:, IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell populations via binding at the
126:
5407:
603:
5181:
5190:
4320:
4089:
3434:
1072:). The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on
1018:
933:
4739:
4534:
5051:
5046:
5031:
4943:
4922:
4371:
4305:
4264:
4162:
3506:
1253:
1185:
It has been shown that combination of IL-3, GM-CSF and stem cell factor enhances peripheral blood stem cells during high-dose chemotherapy.
4912:
4780:
4687:
4666:
4417:
4386:
4381:
4325:
4244:
4958:
4391:
4219:
4214:
2618:
Feng Y, Klein BK, McWherter CA (1996). "Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3".
4564:
4549:
4513:
4483:
4229:
812:
896:
is to regulate the concentrations of various blood-cell types. It induces proliferation and differentiation in both early pluripotent
4155:
4038:
1188:
Other studies showed that IL-3 could be a future perspective therapeutic agent in lymphohematopoietic disorders and solid cancers.
1954:"Enhanced immune costimulatory activity of primary acute myeloid leukaemia blasts after retrovirus-mediated gene transfer of B7.1"
951:
with the goal of initiating proliferation of various other immune cell types. However, IL-3 has also been shown to be produced in
4878:
4874:
4870:
3510:
1271:
1332:
5367:
4634:
3905:
5371:
5357:
5317:
4095:
2524:"Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases"
1819:
1381:
5432:
5386:
4100:
2489:"Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells"
2290:"Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones"
1913:"Ex-vivo expansion of murine marrow cells with IL-3, Il-6, Il-11 and SCF leads to impaired engraftment in irradiated host"
4031:
2930:
1726:
Manzoor H Mangi AC (1999). "Interleukin-3 in hematology and onkology: Current state of knowledge and future directions".
1236:
990:
2140:
Martinez-Moczygemba M, Huston DP (2003). "Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF".
5291:
2288:
Otsuka T, Miyajima A, Brown N, Otsu K, Abrams J, Saeland S, Caux C, de Waal
Malefijt R, de Vries J, Meyerson P (1988).
1139:
In the early 1960s
Ginsberg and Sachs discovered that IL-3 is a potent mast cell growth factor produced from activated
4239:
3796:
1647:
1097:). This β subunit sharing explains the biological functional similarities of different hematopoietic growth factors.
2371:"The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q"
2792:
Tabira T, Chui DH, Fan JP, Shirabe T, Konishi Y (1998). "Interleukin-3 and interleukin-3 receptors in the brain".
3326:
2751:"CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2"
1240:
959:
909:
5252:
5231:
3103:
2050:
Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994).
49:
646:
189:
164:
114:
1845:"Effects of purified bacterially synthesised murine multi CSF (IL3) on hematopoiesis in normal adult mice"
3939:
3489:
3264:
1197:
3972:
3774:
3484:
1120:
202:
4054:
3893:
3578:
2661:, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (1997).
2632:
2522:
Le Beau MM, Espinosa R, Neuman WL, Stock W, Roulston D, Larson RA, Keinanen M, Westbrook CA (1993).
195:
101:
3928:
3355:
3331:
1522:"Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis"
1175:
998:
2001:
Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (June 1996).
1466:
Guthridge MA, Stomski FC, Thomas D, Woodcock JM, Bagley CJ, Berndt MC, Lopez AF (September 1998).
5210:
5170:
5149:
5093:
5061:
5020:
4978:
4932:
4851:
4825:
4769:
4728:
4702:
4676:
4330:
2923:
994:
2716:"The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling"
776:
731:
4645:
4625:
4604:
4523:
4462:
4406:
4360:
4284:
4189:
3256:
2627:
1090:
941:
5437:
2575:
Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (1996).
4178:
3782:
2837:
Nilsen EM, Johansen FE, Jahnsen FL, Lundin KE, Scholz T, Brandtzaeg P, Haraldsen G (1998).
2801:
2674:
2535:
2382:
2252:
1073:
178:
1754:
8:
4310:
4204:
3624:
892:
by activated T cells, monocytes/macrophages and stroma cells. The major function of IL-3
134:
2839:"Cytokine profiles of cultured microvascular endothelial cells from the human intestine"
2805:
2678:
2539:
2386:
2256:
4208:
4181:
3791:
3748:
3663:
3370:
2916:
2863:
2838:
2825:
2813:
2780:
2454:"HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells"
2357:
2319:
2276:
2264:
2231:
2194:
2128:
2067:
1784:
1705:
1439:
1387:
1311:
138:
2601:
2576:
2405:
2370:
2369:
Le Beau MM, Epstein ND, O'Brien SJ, Nienhuis AW, Yang YC, Clark SC, Rowley JD (1987).
2103:
Wagemaker G, Burger H, van Gils FC, van Leen RW, Wielenga JJ (1990). "Interleukin-3".
2076:
2051:
2027:
2002:
1811:
1364:
Aiguo W, Guangren D (July 2006). "PMID Observer Design of
Descriptor Linear Systems".
537:
532:
527:
522:
517:
512:
507:
502:
497:
492:
487:
482:
477:
461:
456:
451:
435:
430:
425:
420:
415:
3655:
3274:
3140:
2897:
2888:
2868:
2817:
2772:
2737:
2702:
2697:
2662:
2645:
2606:
2563:
2558:
2523:
2510:
2475:
2440:
2436:
2410:
2349:
2345:
2311:
2268:
2223:
2219:
2186:
2157:
2132:
2120:
2081:
2032:
1983:
1975:
1934:
1893:
1866:
1825:
1815:
1776:
1735:
1697:
1689:
1653:
1643:
1636:
1613:
1605:
1551:
1543:
1497:
1489:
1431:
1423:
1377:
1340:
1303:
1299:
94:
42:
2829:
2784:
2361:
2323:
2280:
2235:
2198:
1802:
Ihle JN, Weinstein Y, Keller J, Henderson L, Palaszynski E (1985). "Interleukin 3".
1788:
1709:
1443:
1315:
5402:
3967:
3888:
3756:
3445:
3279:
2858:
2850:
2809:
2762:
2727:
2692:
2682:
2637:
2596:
2588:
2553:
2543:
2500:
2465:
2432:
2400:
2390:
2341:
2301:
2260:
2215:
2178:
2149:
2112:
2071:
2063:
2022:
2014:
1965:
1924:
1856:
1807:
1766:
1681:
1595:
1533:
1479:
1415:
1369:
1295:
282:
213:
4147:
1001:. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (
5194:
3494:
3180:
2452:
Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S (1995).
1600:
1583:
1391:
1179:
901:
257:
142:
2505:
2488:
2306:
2289:
1771:
1258:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5392:
5382:
5377:
5363:
5349:
5339:
5334:
5281:
5263:
5242:
5221:
5200:
5186:
5160:
5104:
5072:
5036:
4999:
4994:
4989:
4953:
4948:
4862:
4841:
4795:
4744:
4713:
4692:
4427:
4396:
4136:
4118:
4008:
4003:
3858:
3854:
3836:
3831:
3634:
3629:
3619:
3614:
3609:
3604:
3599:
3595:
3564:
3559:
3554:
3533:
3528:
3523:
3518:
3473:
3468:
3463:
3458:
3406:
3391:
3382:
2939:
2767:
2750:
2658:
2153:
1373:
1105:
1100:
IL-3 receptors can be found on a variety of cell types including many immature
1014:
1010:
1929:
1912:
1861:
1844:
1538:
1521:
1108:
such as hemopoietic progenitor cells, as well as certain myeloid progenitors,
5426:
5134:
4790:
4656:
4615:
4539:
4473:
4422:
4315:
4200:
4023:
3998:
3993:
3988:
3934:
3883:
3549:
3453:
3429:
3401:
3396:
3387:
3378:
3160:
2732:
2715:
2470:
2453:
2169:
Mroczko B, Szmitkowski M (2004). "Hematopoietic cytokines as tumor markers".
1979:
1693:
1609:
1547:
1493:
1427:
1101:
1069:
1057:
1053:
1022:
983:
963:
937:
929:
402:
2908:
2548:
2395:
1657:
1419:
351:
296:
5308:
5129:
4815:
4810:
4805:
4554:
4493:
4452:
3479:
3311:
2687:
2641:
2190:
2161:
1739:
1617:
1555:
1468:"Mechanism of Activation of the GM-CSF, IL-3, and IL-5 Family of Receptors"
275:
155:
2872:
2821:
2776:
2741:
2706:
2649:
2610:
2592:
2567:
2514:
2479:
2444:
2414:
2353:
2315:
2272:
2227:
2182:
2124:
2085:
2036:
2018:
1987:
1970:
1953:
1952:
Hirst W, Buggins A, Darling D, Gäken J, Farzaneh F, Mufti GJ (July 1997).
1938:
1897:
1870:
1829:
1780:
1701:
1501:
1435:
1307:
855:
373:
5139:
5119:
5082:
4917:
4907:
4759:
4754:
4589:
4559:
4498:
4340:
4300:
4259:
4254:
3900:
3846:
3587:
3346:
3269:
2854:
1213:
1167:
1002:
971:
928:) that can improve the body's natural response to disease as part of the
921:
689:
1584:"GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation"
1484:
1467:
1174:. However, only IL-3 treatment in bone marrow failure disorders such as
5124:
5114:
5009:
4902:
4897:
4718:
4579:
4569:
4503:
4437:
4350:
4345:
4274:
3953:
3646:
3336:
3296:
2116:
1685:
1128:
1113:
1065:
967:
172:
122:
1272:"Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)"
71:
4594:
4584:
4574:
4447:
2958:
2749:
Sanchez X, Suetomi K, Cousins-Hodges B, Horton JK, Navarro J (1998).
1049:
1041:
897:
567:
241:
228:
130:
2714:
Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997).
4234:
4062:
3948:
2943:
1633:
1171:
1109:
1006:
979:
925:
905:
893:
844:
2748:
1123:
cell signalization pathway. It can stimulate transcription factor
904:. It also has many more specific effects like the regeneration of
5353:
4836:
4128:
2902:
2892:
2368:
2049:
1152:
1061:
1045:
1037:
1029:
962: IL-3 is capable of stimulating differentiation of immature
877:
675:
632:
552:
548:
2451:
1404:
118:
4968:
4080:
3826:
3723:
3718:
3713:
3708:
3703:
3698:
3416:
3221:
3205:
3200:
3195:
3190:
3185:
3175:
3170:
2656:
2102:
1910:
1140:
1077:
1040:
can either induce their own proliferation and differentiation (
1033:
955:
948:
825:
589:
513:
positive regulation of tyrosine phosphorylation of STAT protein
382:
1465:
5275:
5271:
5267:
4886:
4882:
4866:
4110:
3862:
3821:
3816:
3811:
3806:
3801:
3738:
3728:
3693:
3688:
3683:
3678:
3673:
3668:
3321:
3316:
3306:
3291:
3286:
3165:
3155:
3150:
3145:
3135:
3130:
3124:
3108:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
2487:
Than S, Oyaizu N, Pahwa RN, Kalyanaraman VS, Pahwa S (1994).
1201:
881:
2887:
Overview of all the structural information available in the
2663:"P110delta, a novel phosphoinositide 3-kinase in leukocytes"
1801:
3786:
3733:
3301:
3242:
3237:
3017:
3012:
3007:
3002:
2996:
2990:
2984:
2978:
2973:
2836:
2486:
1670:
888:
2521:
2242:
1911:
Peters SO, Kittler EL, Ramshaw HS, Quesenberry PJ (1996).
1064:(upregulated upon cell activation, under the induction of
5343:
2139:
1883:
1806:. Methods in Enzymology. Vol. 116. pp. 540–52.
1124:
952:
2574:
2330:
2205:
2000:
1951:
1284:
1151:
IL-3 is produced by T cells only after stimulation with
498:
positive regulation of peptidyl-tyrosine phosphorylation
265:
2421:
2287:
2713:
1843:
Metcalf D, Begley CG, Johnson GR, et al. (1986).
1036:
from the bone marrow in an immune response. Activated
932:. In conjunction with other β common chain cytokines
363:
2791:
1842:
1634:
Delves, Peter J., Roitt, Ivan
Maurice, eds. (1998).
538:
positive regulation of cell population proliferation
4177:
1581:
1327:
1325:
1080:gene, and its function is quite similar to GM-CSF.
2617:
2168:
1752:
1635:
1519:
1232:
1230:
1228:
523:regulation of cytokine-mediated signaling pathway
212:
5424:
4090:Granulocyte macrophage colony-stimulating factor
1520:Wang AA, Gommerman JL, Rojas OL (January 2021).
1322:
1019:Granulocyte macrophage colony-stimulating factor
989:Interleukin 3 stimulates the differentiation of
1725:
1359:
1357:
1225:
16:Protein-coding gene in the species Homo sapiens
4053:
1013:), in conjunction with other cytokines, e.g.,
4163:
4039:
2938:
2924:
1582:Dougan M, Dranoff G, Dougan SK (April 2019).
1363:
1354:
1028:IL-3 is secreted by basophils and activated
2043:
1994:
1795:
1753:Ihle JN, Pepersack L, Rebar L (June 1981).
1746:
1642:(2nd ed.). San Diego: Academic Press.
1237:GRCh38: Ensembl release 89: ENSG00000164399
4170:
4156:
4046:
4032:
2931:
2917:
1278:
2862:
2766:
2731:
2696:
2686:
2631:
2600:
2557:
2547:
2504:
2469:
2404:
2394:
2305:
2075:
2026:
1969:
1928:
1860:
1770:
1728:Cytokines, Cellular and Molecular Therapy
1599:
1537:
1483:
1032:to support growth and differentiation of
528:regulation of signaling receptor activity
5335:Interleukin 14 (taxilin alpha, HMW-BCGF)
1161:
958:and may be involved in earlier antibody
908:and potentially aids in early antibody
5425:
4633:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
105:, interleukin 3, IL-3, MCGF, MULTI-CSF
4151:
4096:Granulocyte colony-stimulating factor
4027:
2912:
1721:
1719:
1629:
1627:
1577:
1575:
1573:
1571:
1569:
1567:
1565:
1264:
947:IL-3 is mainly produced by activated
217:
176:
171:
4101:Macrophage colony-stimulating factor
1515:
1513:
1511:
1461:
1459:
1457:
1455:
1453:
1127:(activation of gene expression) and
997:or, with the addition of IL-7, into
991:multipotent hematopoietic stem cells
533:cytokine-mediated signaling pathway
13:
2814:10.1111/j.1749-6632.1998.tb09554.x
2265:10.1111/j.1749-6632.1989.tb22418.x
2095:
2068:10.1002/j.1460-2075.1994.tb06848.x
1716:
1624:
1562:
457:intracellular anatomical structure
14:
5449:
2881:
1508:
1450:
508:peptidyl-tyrosine phosphorylation
1804:Immunochemical Techniques Part H
1196:Interleukin 3 has been shown to
431:protein tyrosine kinase activity
372:
201:
194:
188:
163:
5161:Interleukin 27 (interleukin 30)
1945:
1904:
1877:
1836:
1664:
1366:2007 Chinese Control Conference
1191:
924:, a type of biological signal (
1398:
1246:
1119:IL-3/Receptor complex induces
436:interleukin-1 receptor binding
421:interleukin-3 receptor binding
383:More reference expression data
352:More reference expression data
1:
1812:10.1016/S0076-6879(85)16042-8
1219:
1044:signaling), or that of other
186:
2667:Proc. Natl. Acad. Sci. U.S.A
2528:Proc. Natl. Acad. Sci. U.S.A
2437:10.1016/0378-1119(87)90254-X
2375:Proc. Natl. Acad. Sci. U.S.A
2346:10.1016/0092-8674(86)90360-0
2220:10.1016/0092-8674(91)90039-2
1601:10.1016/j.immuni.2019.03.022
1526:Journal of Molecular Biology
1300:10.1016/0092-8674(86)90360-0
1155:or other specific impulses.
1134:
1131:(suppression of apoptosis).
1076:, only 9 kilobases from the
7:
5433:Genes on human chromosome 5
4511:Antisense oligonucleotides:
2506:10.1182/blood.V84.1.184.184
2307:10.4049/jimmunol.140.7.2288
1772:10.4049/jimmunol.126.6.2184
1207:
1083:
915:
10:
5454:
4055:Colony-stimulating factors
2768:10.4049/jimmunol.160.2.906
2154:10.1016/j.jaci.2003.08.015
1638:Encyclopedia of immunology
1374:10.1109/chicc.2006.4347343
1368:. IEEE. pp. 161–165.
1146:
1052:signaling) – both involve
493:nervous system development
5327:
5307:
5300:
5251:
5230:
5209:
5169:
5148:
5092:
5060:
5019:
4977:
4931:
4850:
4824:
4768:
4727:
4701:
4675:
4644:
4624:
4603:
4522:
4461:
4405:
4359:
4283:
4188:
4127:
4109:
4079:
4061:
3918:
3894:Colony-stimulating factor
3876:
3845:
3773:
3747:
3654:
3645:
3586:
3577:
3542:
3505:
3443:
3415:
3369:
3354:
3345:
3255:
3230:
3214:
3117:
2966:
2957:
2950:
1930:10.1182/blood.V87.1.30.30
1862:10.1182/blood.V68.1.46.46
1539:10.1016/j.jmb.2020.09.014
1337:atlasgeneticsoncology.org
1254:"Human PubMed Reference:"
999:lymphoid progenitor cells
859:
854:
850:
843:
824:
813:Chr 5: 132.06 – 132.06 Mb
807:
794:
790:
773:
769:
762:
749:
745:
728:
724:
717:
706:
702:
687:
683:
674:
663:
659:
644:
640:
631:
620:
616:
601:
597:
588:
573:
566:
562:
546:
401:
397:
380:
371:
362:
349:
336:
332:
303:
294:
264:
256:
252:
235:
222:
185:
162:
153:
149:
112:
109:
99:
92:
87:
68:
63:
46:
41:
36:
32:
28:
23:
3929:proinflammatory cytokine
2733:10.1074/jbc.272.36.22630
2471:10.1074/jbc.270.33.19364
2142:J. Allergy Clin. Immunol
1182:(AA) was disappointing.
1176:myelodysplastic syndrome
995:myeloid progenitor cells
5201:Interleukin-29 (IFN-λ1)
4346:Daclizumab (dacliximab)
4331:Tucotuzumab celmoleukin
2901:(Interleukin-3) at the
2549:10.1073/pnas.90.12.5484
2396:10.1073/pnas.84.16.5913
2148:(4): 653–65, quiz 666.
1420:10.1002/stem.5530110814
982:via the development of
966:causing changes to the
5182:Interferon λ4 (IFN-λ4)
4275:Rilonacept (IL-1 Trap)
3060:/PARC/DCCK1/AMAC1/MIP4
2688:10.1073/pnas.94.9.4330
2642:10.1006/jmbi.1996.0337
1886:Bone Marrow Transplant
1091:interleukin-3 receptor
942:interleukin-3 receptor
416:growth factor activity
47:Human UniProt search:
5105:Interleukin 23 (SGRF)
4786:Cintredekin besudotox
4714:Interleukin 11 (AGIF)
4693:Interleukin 10 (CSIF)
2593:10.1128/MCB.16.6.3035
2183:10.1515/CCLM.2004.253
2019:10.1128/MCB.16.6.3035
1971:10.1038/sj.gt.3300437
1333:"IL3 (interleukin-3)"
1162:Immunological therapy
483:embryonic hemopoiesis
4179:Interleukin receptor
2855:10.1136/gut.42.5.635
2794:Ann. N. Y. Acad. Sci
2245:Ann. N. Y. Acad. Sci
2171:Clin. Chem. Lab. Med
1102:myelomonocytic cells
964:myelomonocytic cells
920:Interleukin 3 is an
452:extracellular region
179:Chromosome 5 (human)
64:List of PDB id codes
37:Available structures
4311:Denileukin diftitox
3625:Interferon type III
2806:1998NYASA.840..107T
2679:1997PNAS...94.4330V
2540:1993PNAS...90.5484B
2387:1987PNAS...84.5913L
2257:1989NYASA.554..167U
1485:10.1002/stem.160301
488:cell-cell signaling
462:extracellular space
4883:E (interleukin 25)
2657:Vanhaesebroeck B,
2117:10.1007/BF02170083
1686:10.1007/bf00210610
1106:hemopoietic system
960:isotype switching.
884:is encoded by the
471:Biological process
445:Cellular component
409:Molecular function
5420:
5419:
5416:
5415:
5385:(signals through
5366:(signals through
5352:(signals through
5342:(signals through
4966:Binding proteins:
4296:Adargileukin alfa
4145:
4144:
4021:
4020:
3914:
3913:
3872:
3871:
3769:
3768:
3765:
3764:
3573:
3572:
3251:
3250:
1821:978-0-12-182016-9
1383:978-7-81124-055-9
910:isotype switching
867:
866:
863:
862:
839:
838:
803:
802:
784:
783:
758:
757:
739:
738:
713:
712:
696:
695:
670:
669:
653:
652:
627:
626:
610:
609:
558:
557:
426:cytokine activity
393:
392:
389:
388:
358:
357:
345:
344:
326:
325:
248:
247:
83:
82:
79:
78:
5445:
5408:Efineptakin alfa
5403:Efavaleukin alfa
5305:
5304:
4272:Decoy receptors:
4172:
4165:
4158:
4149:
4148:
4092:
4048:
4041:
4034:
4025:
4024:
3652:
3651:
3584:
3583:
3367:
3366:
3352:
3351:
2964:
2963:
2955:
2954:
2933:
2926:
2919:
2910:
2909:
2876:
2866:
2833:
2788:
2770:
2745:
2735:
2726:(36): 22630–41.
2710:
2700:
2690:
2653:
2635:
2614:
2604:
2571:
2561:
2551:
2518:
2508:
2483:
2473:
2448:
2418:
2408:
2398:
2365:
2327:
2309:
2284:
2239:
2202:
2165:
2136:
2090:
2089:
2079:
2047:
2041:
2040:
2030:
1998:
1992:
1991:
1973:
1949:
1943:
1942:
1932:
1908:
1902:
1901:
1881:
1875:
1874:
1864:
1840:
1834:
1833:
1799:
1793:
1792:
1774:
1750:
1744:
1743:
1723:
1714:
1713:
1668:
1662:
1661:
1641:
1631:
1622:
1621:
1603:
1579:
1560:
1559:
1541:
1517:
1506:
1505:
1487:
1463:
1448:
1447:
1402:
1396:
1395:
1361:
1352:
1351:
1349:
1348:
1339:. Archived from
1329:
1320:
1319:
1282:
1276:
1275:
1268:
1262:
1261:
1250:
1244:
1234:
852:
851:
835:
820:
815:
798:
788:
787:
779:
767:
766:
763:RefSeq (protein)
753:
743:
742:
734:
722:
721:
700:
699:
681:
680:
657:
656:
638:
637:
614:
613:
595:
594:
564:
563:
518:fever generation
399:
398:
385:
376:
369:
368:
354:
330:
329:
299:
297:Top expressed in
292:
291:
271:
270:
254:
253:
244:
231:
220:
205:
198:
192:
181:
167:
151:
150:
145:
104:
97:
74:
61:
60:
55:
34:
33:
21:
20:
5453:
5452:
5448:
5447:
5446:
5444:
5443:
5442:
5423:
5422:
5421:
5412:
5323:
5296:
5247:
5226:
5205:
5165:
5144:
5088:
5085:(against IL-22)
5056:
5015:
5012:(against IL-20)
4973:
4927:
4846:
4820:
4764:
4723:
4697:
4671:
4640:
4620:
4599:
4518:
4457:
4401:
4355:
4279:
4184:
4176:
4146:
4141:
4123:
4105:
4088:
4075:
4057:
4052:
4022:
4017:
3983:
3962:
3920:
3910:
3868:
3841:
3761:
3743:
3641:
3569:
3538:
3501:
3439:
3411:
3362:
3360:
3358:
3341:
3247:
3226:
3210:
3113:
2946:
2937:
2884:
2879:
2633:10.1.1.521.3736
2581:Mol. Cell. Biol
2464:(33): 19364–9.
2177:(12): 1347–54.
2098:
2096:Further reading
2093:
2062:(21): 5176–85.
2048:
2044:
2007:Mol. Cell. Biol
1999:
1995:
1950:
1946:
1909:
1905:
1882:
1878:
1841:
1837:
1822:
1800:
1796:
1751:
1747:
1724:
1717:
1669:
1665:
1650:
1632:
1625:
1580:
1563:
1518:
1509:
1464:
1451:
1403:
1399:
1384:
1362:
1355:
1346:
1344:
1331:
1330:
1323:
1283:
1279:
1270:
1269:
1265:
1252:
1251:
1247:
1235:
1226:
1222:
1210:
1194:
1180:aplastic anemia
1164:
1149:
1137:
1086:
1056:binding to the
1011:dendritic cells
918:
856:View/Edit Human
833:
818:
811:
808:Location (UCSC)
796:
775:
751:
730:
647:ENSG00000164399
542:
503:immune response
466:
440:
381:
350:
341:
322:
317:
313:
309:
307:Achilles tendon
295:
239:
226:
218:
208:
207:
206:
199:
177:
154:Gene location (
143:IL3 - orthologs
113:
100:
93:
70:
48:
17:
12:
11:
5:
5451:
5441:
5440:
5435:
5418:
5417:
5414:
5413:
5411:
5410:
5405:
5396:
5395:
5393:Interleukin 35
5390:
5383:Interleukin 34
5380:
5378:Interleukin 32
5375:
5364:Interleukin 26
5361:
5350:Interleukin 24
5347:
5340:Interleukin 16
5337:
5331:
5329:
5325:
5324:
5322:
5321:
5313:
5311:
5302:
5298:
5297:
5295:
5294:
5285:
5284:
5282:Interleukin 38
5279:
5264:Interleukin 36
5257:
5255:
5249:
5248:
5246:
5245:
5243:Interleukin 33
5236:
5234:
5228:
5227:
5225:
5224:
5222:Interleukin 31
5215:
5213:
5207:
5206:
5204:
5203:
5198:
5187:Interleukin 28
5184:
5175:
5173:
5167:
5166:
5164:
5163:
5154:
5152:
5146:
5145:
5143:
5142:
5137:
5132:
5127:
5122:
5117:
5108:
5107:
5098:
5096:
5090:
5089:
5087:
5086:
5076:
5075:
5073:Interleukin 22
5066:
5064:
5058:
5057:
5055:
5054:
5049:
5040:
5039:
5037:Interleukin 21
5034:
5025:
5023:
5017:
5016:
5014:
5013:
5003:
5002:
5000:Interleukin 24
4997:
4995:Interleukin 20
4992:
4990:Interleukin 19
4983:
4981:
4975:
4974:
4972:
4971:
4962:
4961:
4956:
4954:Interleukin 37
4951:
4949:Interleukin 18
4946:
4937:
4935:
4929:
4928:
4926:
4925:
4920:
4915:
4910:
4905:
4900:
4891:
4890:
4863:Interleukin 17
4856:
4854:
4848:
4847:
4845:
4844:
4842:Interleukin 15
4839:
4830:
4828:
4822:
4821:
4819:
4818:
4813:
4808:
4799:
4798:
4796:Interleukin 13
4793:
4788:
4783:
4774:
4772:
4766:
4765:
4763:
4762:
4757:
4748:
4747:
4745:Interleukin 12
4742:
4733:
4731:
4725:
4724:
4722:
4721:
4716:
4707:
4705:
4699:
4698:
4696:
4695:
4690:
4681:
4679:
4673:
4672:
4670:
4669:
4660:
4659:
4650:
4648:
4642:
4641:
4639:
4638:
4630:
4628:
4622:
4621:
4619:
4618:
4609:
4607:
4601:
4600:
4598:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4543:
4542:
4537:
4528:
4526:
4520:
4519:
4517:
4516:
4507:
4506:
4501:
4496:
4487:
4486:
4477:
4476:
4467:
4465:
4459:
4458:
4456:
4455:
4450:
4441:
4440:
4431:
4430:
4428:Interleukin 13
4425:
4420:
4411:
4409:
4403:
4402:
4400:
4399:
4397:Promegapoietin
4394:
4389:
4384:
4379:
4374:
4365:
4363:
4357:
4356:
4354:
4353:
4348:
4343:
4334:
4333:
4328:
4323:
4321:Pegaldesleukin
4318:
4313:
4308:
4303:
4298:
4289:
4287:
4281:
4280:
4278:
4277:
4268:
4267:
4262:
4257:
4248:
4247:
4242:
4237:
4232:
4223:
4222:
4217:
4212:
4194:
4192:
4186:
4185:
4175:
4174:
4167:
4160:
4152:
4143:
4142:
4140:
4139:
4137:Thrombopoietin
4133:
4131:
4125:
4124:
4122:
4121:
4119:Erythropoietin
4115:
4113:
4107:
4106:
4104:
4103:
4098:
4093:
4085:
4083:
4077:
4076:
4074:
4073:
4067:
4065:
4059:
4058:
4051:
4050:
4043:
4036:
4028:
4019:
4018:
4016:
4015:
4014:
4013:
4012:
4011:
4006:
4001:
3996:
3991:
3981:
3977:
3976:
3975:
3970:
3960:
3951:
3945:
3944:
3943:
3942:
3937:
3924:
3922:
3916:
3915:
3912:
3911:
3909:
3908:
3903:
3898:
3897:
3896:
3891:
3880:
3878:
3874:
3873:
3870:
3869:
3867:
3866:
3851:
3849:
3843:
3842:
3840:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3779:
3777:
3775:Ig superfamily
3771:
3770:
3767:
3766:
3763:
3762:
3760:
3759:
3753:
3751:
3745:
3744:
3742:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3660:
3658:
3649:
3643:
3642:
3640:
3639:
3638:
3637:
3632:
3622:
3617:
3612:
3607:
3602:
3592:
3590:
3581:
3575:
3574:
3571:
3570:
3568:
3567:
3562:
3557:
3552:
3546:
3544:
3540:
3539:
3537:
3536:
3531:
3526:
3521:
3515:
3513:
3503:
3502:
3500:
3499:
3498:
3497:
3492:
3487:
3482:
3471:
3466:
3461:
3456:
3450:
3448:
3441:
3440:
3438:
3437:
3432:
3427:
3421:
3419:
3413:
3412:
3410:
3409:
3404:
3399:
3394:
3385:
3375:
3373:
3364:
3349:
3343:
3342:
3340:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3289:
3284:
3283:
3282:
3277:
3267:
3261:
3259:
3253:
3252:
3249:
3248:
3246:
3245:
3240:
3234:
3232:
3228:
3227:
3225:
3224:
3218:
3216:
3212:
3211:
3209:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3121:
3119:
3115:
3114:
3112:
3111:
3106:
3101:
3096:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2994:
2988:
2982:
2976:
2970:
2968:
2961:
2952:
2948:
2947:
2940:Cell signaling
2936:
2935:
2928:
2921:
2913:
2907:
2906:
2883:
2882:External links
2880:
2878:
2877:
2834:
2789:
2746:
2711:
2654:
2615:
2587:(6): 3035–46.
2572:
2534:(12): 5484–8.
2519:
2484:
2449:
2419:
2381:(16): 5913–7.
2366:
2328:
2300:(7): 2288–95.
2285:
2240:
2214:(6): 1165–74.
2203:
2166:
2137:
2099:
2097:
2094:
2092:
2091:
2042:
2013:(6): 3035–46.
1993:
1964:(7): 691–699.
1944:
1903:
1876:
1835:
1820:
1794:
1745:
1715:
1680:(2): 198–200.
1674:Human Genetics
1663:
1648:
1623:
1594:(4): 796–811.
1561:
1507:
1478:(5): 301–313.
1449:
1397:
1382:
1353:
1321:
1277:
1263:
1245:
1223:
1221:
1218:
1217:
1216:
1209:
1206:
1193:
1190:
1163:
1160:
1148:
1145:
1136:
1133:
1085:
1082:
1021:(GM-CSF), and
1015:Erythropoietin
984:megakaryocytes
917:
914:
900:and committed
865:
864:
861:
860:
858:
848:
847:
841:
840:
837:
836:
831:
829:
822:
821:
816:
809:
805:
804:
801:
800:
792:
791:
785:
782:
781:
771:
770:
764:
760:
759:
756:
755:
747:
746:
740:
737:
736:
726:
725:
719:
715:
714:
711:
710:
704:
703:
697:
694:
693:
685:
684:
678:
672:
671:
668:
667:
661:
660:
654:
651:
650:
642:
641:
635:
629:
628:
625:
624:
618:
617:
611:
608:
607:
599:
598:
592:
586:
585:
580:
575:
571:
570:
560:
559:
556:
555:
544:
543:
541:
540:
535:
530:
525:
520:
515:
510:
505:
500:
495:
490:
485:
480:
474:
472:
468:
467:
465:
464:
459:
454:
448:
446:
442:
441:
439:
438:
433:
428:
423:
418:
412:
410:
406:
405:
395:
394:
391:
390:
387:
386:
378:
377:
366:
360:
359:
356:
355:
347:
346:
343:
342:
340:
337:
334:
333:
327:
324:
323:
321:
320:
316:
312:
308:
304:
301:
300:
288:
287:
279:
268:
262:
261:
258:RNA expression
250:
249:
246:
245:
237:
233:
232:
224:
221:
216:
210:
209:
200:
193:
187:
183:
182:
175:
169:
168:
160:
159:
147:
146:
111:
107:
106:
98:
90:
89:
85:
84:
81:
80:
77:
76:
66:
65:
57:
56:
45:
39:
38:
30:
29:
26:
25:
15:
9:
6:
4:
3:
2:
5450:
5439:
5436:
5434:
5431:
5430:
5428:
5409:
5406:
5404:
5401:
5398:
5397:
5394:
5391:
5388:
5384:
5381:
5379:
5376:
5373:
5369:
5365:
5362:
5359:
5355:
5351:
5348:
5345:
5341:
5338:
5336:
5333:
5332:
5330:
5326:
5319:
5315:
5314:
5312:
5310:
5306:
5303:
5299:
5293:
5290:
5287:
5286:
5283:
5280:
5277:
5273:
5269:
5265:
5262:
5259:
5258:
5256:
5254:
5250:
5244:
5241:
5238:
5237:
5235:
5233:
5229:
5223:
5220:
5217:
5216:
5214:
5212:
5208:
5202:
5199:
5196:
5192:
5188:
5185:
5183:
5180:
5177:
5176:
5174:
5172:
5168:
5162:
5159:
5156:
5155:
5153:
5151:
5147:
5141:
5138:
5136:
5135:Tildrakizumab
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5110:
5109:
5106:
5103:
5100:
5099:
5097:
5095:
5091:
5084:
5081:
5078:
5077:
5074:
5071:
5068:
5067:
5065:
5063:
5059:
5053:
5050:
5048:
5045:
5042:
5041:
5038:
5035:
5033:
5030:
5027:
5026:
5024:
5022:
5018:
5011:
5008:
5005:
5004:
5001:
4998:
4996:
4993:
4991:
4988:
4985:
4984:
4982:
4980:
4976:
4970:
4967:
4964:
4963:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4942:
4939:
4938:
4936:
4934:
4930:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4893:
4892:
4888:
4884:
4880:
4876:
4872:
4868:
4864:
4861:
4858:
4857:
4855:
4853:
4849:
4843:
4840:
4838:
4835:
4832:
4831:
4829:
4827:
4823:
4817:
4814:
4812:
4809:
4807:
4804:
4801:
4800:
4797:
4794:
4792:
4791:Interleukin 4
4789:
4787:
4784:
4782:
4779:
4776:
4775:
4773:
4771:
4767:
4761:
4758:
4756:
4753:
4750:
4749:
4746:
4743:
4741:
4740:Edodekin alfa
4738:
4735:
4734:
4732:
4730:
4726:
4720:
4717:
4715:
4712:
4709:
4708:
4706:
4704:
4700:
4694:
4691:
4689:
4686:
4683:
4682:
4680:
4678:
4674:
4668:
4665:
4662:
4661:
4658:
4657:Interleukin 9
4655:
4652:
4651:
4649:
4647:
4643:
4636:
4632:
4631:
4629:
4627:
4623:
4617:
4616:Interleukin 7
4614:
4611:
4610:
4608:
4606:
4602:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4545:
4544:
4541:
4540:Interleukin 6
4538:
4536:
4535:Atexakin alfa
4533:
4530:
4529:
4527:
4525:
4521:
4515:
4512:
4509:
4508:
4505:
4502:
4500:
4497:
4495:
4492:
4489:
4488:
4485:
4482:
4479:
4478:
4475:
4474:Interleukin 5
4472:
4469:
4468:
4466:
4464:
4460:
4454:
4451:
4449:
4446:
4443:
4442:
4439:
4436:
4433:
4432:
4429:
4426:
4424:
4423:Interleukin 4
4421:
4419:
4416:
4413:
4412:
4410:
4408:
4404:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4378:
4377:Interleukin 3
4375:
4373:
4370:
4367:
4366:
4364:
4362:
4358:
4352:
4349:
4347:
4344:
4342:
4339:
4336:
4335:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4316:Interleukin 2
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4291:
4290:
4288:
4286:
4282:
4276:
4273:
4270:
4269:
4266:
4263:
4261:
4258:
4256:
4253:
4250:
4249:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4225:
4224:
4221:
4218:
4216:
4213:
4210:
4206:
4202:
4201:Interleukin 1
4199:
4196:
4195:
4193:
4191:
4187:
4183:
4180:
4173:
4168:
4166:
4161:
4159:
4154:
4153:
4150:
4138:
4135:
4134:
4132:
4130:
4126:
4120:
4117:
4116:
4114:
4112:
4108:
4102:
4099:
4097:
4094:
4091:
4087:
4086:
4084:
4082:
4078:
4072:
4071:Interleukin 3
4069:
4068:
4066:
4064:
4060:
4056:
4049:
4044:
4042:
4037:
4035:
4030:
4029:
4026:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3986:
3985:
3978:
3974:
3971:
3969:
3966:
3965:
3964:
3957:
3956:
3955:
3952:
3950:
3947:
3946:
3941:
3938:
3936:
3933:
3932:
3931:
3930:
3926:
3925:
3923:
3917:
3907:
3904:
3902:
3899:
3895:
3892:
3890:
3887:
3886:
3885:
3884:Hematopoietic
3882:
3881:
3879:
3875:
3864:
3860:
3856:
3853:
3852:
3850:
3848:
3844:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3784:
3781:
3780:
3778:
3776:
3772:
3758:
3755:
3754:
3752:
3750:
3746:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3661:
3659:
3657:
3653:
3650:
3648:
3644:
3636:
3633:
3631:
3628:
3627:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3597:
3594:
3593:
3591:
3589:
3585:
3582:
3580:
3576:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3547:
3545:
3541:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3516:
3514:
3512:
3508:
3504:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3477:
3476:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3451:
3449:
3447:
3442:
3436:
3433:
3431:
3428:
3426:
3423:
3422:
3420:
3418:
3414:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3389:
3386:
3384:
3380:
3377:
3376:
3374:
3372:
3368:
3365:
3357:
3353:
3350:
3348:
3344:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3292:TNFSF5/CD40LG
3290:
3288:
3285:
3281:
3278:
3276:
3273:
3272:
3271:
3268:
3266:
3263:
3262:
3260:
3258:
3254:
3244:
3241:
3239:
3236:
3235:
3233:
3229:
3223:
3220:
3219:
3217:
3213:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3126:
3123:
3122:
3120:
3116:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2998:
2995:
2992:
2989:
2986:
2983:
2980:
2977:
2975:
2972:
2971:
2969:
2965:
2962:
2960:
2956:
2953:
2949:
2945:
2941:
2934:
2929:
2927:
2922:
2920:
2915:
2914:
2911:
2904:
2900:
2899:
2894:
2890:
2886:
2885:
2874:
2870:
2865:
2860:
2856:
2852:
2849:(5): 635–42.
2848:
2844:
2840:
2835:
2831:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2800:(1): 107–16.
2799:
2795:
2790:
2786:
2782:
2778:
2774:
2769:
2764:
2761:(2): 906–10.
2760:
2756:
2752:
2747:
2743:
2739:
2734:
2729:
2725:
2721:
2720:J. Biol. Chem
2717:
2712:
2708:
2704:
2699:
2694:
2689:
2684:
2680:
2676:
2673:(9): 4330–5.
2672:
2668:
2664:
2660:
2655:
2651:
2647:
2643:
2639:
2634:
2629:
2626:(3): 524–41.
2625:
2621:
2616:
2612:
2608:
2603:
2598:
2594:
2590:
2586:
2582:
2578:
2573:
2569:
2565:
2560:
2555:
2550:
2545:
2541:
2537:
2533:
2529:
2525:
2520:
2516:
2512:
2507:
2502:
2498:
2494:
2490:
2485:
2481:
2477:
2472:
2467:
2463:
2459:
2458:J. Biol. Chem
2455:
2450:
2446:
2442:
2438:
2434:
2431:(1): 115–24.
2430:
2426:
2420:
2416:
2412:
2407:
2402:
2397:
2392:
2388:
2384:
2380:
2376:
2372:
2367:
2363:
2359:
2355:
2351:
2347:
2343:
2339:
2335:
2329:
2325:
2321:
2317:
2313:
2308:
2303:
2299:
2295:
2291:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2254:
2251:(1): 167–76.
2250:
2246:
2241:
2237:
2233:
2229:
2225:
2221:
2217:
2213:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2172:
2167:
2163:
2159:
2155:
2151:
2147:
2143:
2138:
2134:
2130:
2126:
2122:
2118:
2114:
2111:(4): 337–45.
2110:
2106:
2101:
2100:
2087:
2083:
2078:
2073:
2069:
2065:
2061:
2057:
2053:
2046:
2038:
2034:
2029:
2024:
2020:
2016:
2012:
2008:
2004:
1997:
1989:
1985:
1981:
1977:
1972:
1967:
1963:
1959:
1955:
1948:
1940:
1936:
1931:
1926:
1922:
1918:
1914:
1907:
1899:
1895:
1892:(6): 855–62.
1891:
1887:
1880:
1872:
1868:
1863:
1858:
1854:
1850:
1846:
1839:
1831:
1827:
1823:
1817:
1813:
1809:
1805:
1798:
1790:
1786:
1782:
1778:
1773:
1768:
1765:(6): 2184–9.
1764:
1760:
1756:
1749:
1741:
1737:
1733:
1729:
1722:
1720:
1711:
1707:
1703:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1667:
1659:
1655:
1651:
1649:0-12-226765-6
1645:
1640:
1639:
1630:
1628:
1619:
1615:
1611:
1607:
1602:
1597:
1593:
1589:
1585:
1578:
1576:
1574:
1572:
1570:
1568:
1566:
1557:
1553:
1549:
1545:
1540:
1535:
1532:(1): 166655.
1531:
1527:
1523:
1516:
1514:
1512:
1503:
1499:
1495:
1491:
1486:
1481:
1477:
1473:
1469:
1462:
1460:
1458:
1456:
1454:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1417:
1414:(S2): 83–87.
1413:
1409:
1401:
1393:
1389:
1385:
1379:
1375:
1371:
1367:
1360:
1358:
1343:on 2022-02-05
1342:
1338:
1334:
1328:
1326:
1317:
1313:
1309:
1305:
1301:
1297:
1293:
1289:
1281:
1273:
1267:
1259:
1255:
1249:
1242:
1238:
1233:
1231:
1229:
1224:
1215:
1212:
1211:
1205:
1203:
1199:
1189:
1186:
1183:
1181:
1177:
1173:
1169:
1159:
1156:
1154:
1144:
1142:
1132:
1130:
1126:
1122:
1117:
1115:
1111:
1107:
1103:
1098:
1096:
1092:
1081:
1079:
1075:
1071:
1067:
1063:
1059:
1058:IL-2 receptor
1055:
1051:
1047:
1043:
1039:
1035:
1031:
1026:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
992:
987:
985:
981:
975:
973:
969:
965:
961:
957:
954:
950:
945:
943:
939:
935:
931:
930:immune system
927:
923:
913:
911:
907:
903:
899:
895:
890:
887:
883:
879:
875:
871:
870:Interleukin 3
857:
853:
849:
846:
842:
832:
830:
827:
823:
817:
814:
810:
806:
799:
793:
789:
786:
780:
778:
772:
768:
765:
761:
754:
748:
744:
741:
735:
733:
727:
723:
720:
718:RefSeq (mRNA)
716:
709:
705:
701:
698:
692:
691:
686:
682:
679:
677:
673:
666:
662:
658:
655:
649:
648:
643:
639:
636:
634:
630:
623:
619:
615:
612:
606:
605:
600:
596:
593:
591:
587:
584:
581:
579:
576:
572:
569:
565:
561:
554:
550:
545:
539:
536:
534:
531:
529:
526:
524:
521:
519:
516:
514:
511:
509:
506:
504:
501:
499:
496:
494:
491:
489:
486:
484:
481:
479:
476:
475:
473:
470:
469:
463:
460:
458:
455:
453:
450:
449:
447:
444:
443:
437:
434:
432:
429:
427:
424:
422:
419:
417:
414:
413:
411:
408:
407:
404:
403:Gene ontology
400:
396:
384:
379:
375:
370:
367:
365:
361:
353:
348:
338:
335:
331:
328:
318:
314:
310:
306:
305:
302:
298:
293:
290:
289:
286:
284:
280:
278:
277:
273:
272:
269:
267:
263:
259:
255:
251:
243:
238:
234:
230:
225:
215:
211:
204:
197:
191:
184:
180:
174:
170:
166:
161:
157:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
108:
103:
96:
91:
86:
75:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
19:
5438:Interleukins
5399:
5387:M-CSFR/CSF1R
5374:heterodimer)
5360:heterodimer)
5289:Antagonists:
5288:
5260:
5239:
5218:
5178:
5157:
5130:Risankizumab
5111:
5101:
5079:
5069:
5052:NNC0114-0006
5047:NNC0114-0005
5043:
5028:
5006:
4986:
4965:
4940:
4894:
4859:
4833:
4816:Tralokinumab
4811:Lebrikizumab
4806:Anrukinzumab
4802:
4777:
4751:
4736:
4710:
4684:
4663:
4653:
4612:
4555:Clazakizumab
4546:
4531:
4510:
4494:Benralizumab
4490:
4481:Antagonists:
4480:
4470:
4453:Pascolizumab
4444:
4435:Antagonists:
4434:
4414:
4376:
4368:
4337:
4292:
4271:
4251:
4227:Antagonists:
4226:
4197:
4070:
3979:
3958:
3927:
3919:By function/
3630:IL28/IFNL2+3
3424:
2896:
2846:
2842:
2797:
2793:
2758:
2754:
2723:
2719:
2670:
2666:
2623:
2620:J. Mol. Biol
2619:
2584:
2580:
2531:
2527:
2499:(1): 184–8.
2496:
2492:
2461:
2457:
2428:
2424:
2378:
2374:
2337:
2333:
2297:
2293:
2248:
2244:
2211:
2207:
2174:
2170:
2145:
2141:
2108:
2104:
2059:
2055:
2045:
2010:
2006:
1996:
1961:
1958:Gene Therapy
1957:
1947:
1920:
1916:
1906:
1889:
1885:
1879:
1855:(1): 46–57.
1852:
1848:
1838:
1803:
1797:
1762:
1758:
1748:
1734:(2): 87–95.
1731:
1727:
1677:
1673:
1666:
1637:
1591:
1587:
1529:
1525:
1475:
1471:
1411:
1407:
1400:
1365:
1345:. Retrieved
1341:the original
1336:
1291:
1287:
1280:
1266:
1257:
1248:
1195:
1192:Interactions
1187:
1184:
1168:granulocytes
1165:
1157:
1150:
1138:
1118:
1099:
1087:
1074:chromosome 5
1027:
1003:granulocytes
988:
976:
946:
919:
885:
873:
869:
868:
795:
774:
750:
729:
707:
688:
664:
645:
621:
602:
582:
577:
478:MAPK cascade
281:
274:
240:132,063,204
227:132,060,655
110:External IDs
69:
18:
5140:Ustekinumab
5120:Briakinumab
5112:Antibodies:
5083:Fezakinumab
5080:Antibodies:
5044:Antibodies:
5032:Denenicokin
5007:Antibodies:
4944:Iboctadekin
4923:Vunakizumab
4918:Secukinumab
4908:Perakizumab
4895:Antibodies:
4803:Antibodies:
4760:Ustekinumab
4755:Briakinumab
4752:Antibodies:
4664:Antibodies:
4590:Tocilizumab
4560:Elsilimomab
4547:Antibodies:
4499:Mepolizumab
4491:Antibodies:
4445:Antibodies:
4372:Daniplestim
4341:Basiliximab
4338:Antibodies:
4306:Celmoleukin
4301:Aldesleukin
4265:Lutikizumab
4260:Gevokizumab
4255:Canakinumab
4252:Antibodies:
3847:IL17 family
3588:IL10 family
3507:IL12 family
3359:(grouped by
3347:Interleukin
3270:Lymphotoxin
2340:(1): 3–10.
1923:(1): 30–7.
1294:(1): 3–10.
1214:Interleukin
1129:Ras pathway
1114:eosinophils
972:granulocyte
922:interleukin
902:progenitors
311:bone marrow
88:Identifiers
5427:Categories
5195:B (IFN-λ3)
5191:A (IFN-λ2)
5125:Guselkumab
5115:Brazikumab
5010:Fletikumab
4913:Remtolumab
4903:Ixekizumab
4898:Brodalumab
4781:Binetrakin
4719:Oprelvekin
4688:Ilodecakin
4667:Enokizumab
4580:Siltuximab
4570:Olokizumab
4504:Reslizumab
4438:Pitrakinra
4418:Binetrakin
4387:Milodistim
4382:Leridistim
4351:Inolimomab
4326:Teceleukin
4245:Isunakinra
4182:modulators
3954:Lymphokine
3792:IL1B/IL1F2
3787:IL1A/IL1F1
3783:IL1 family
3647:Interferon
3635:IL29/IFNL1
2755:J. Immunol
2294:J. Immunol
2105:Biotherapy
1759:J. Immunol
1672:22q13.1".
1472:Stem Cells
1408:Stem Cells
1347:2019-06-19
1243:, May 2017
1220:References
1178:(MDS) and
1121:JAK2/STAT5
1068:-secreted
1066:macrophage
968:macrophage
898:stem cells
315:lymph node
285:(ortholog)
123:HomoloGene
5400:Unsorted:
5261:Agonists:
5240:Agonists:
5219:Agonists:
5179:Agonists:
5158:Agonists:
5102:Agonists:
5070:Agonists:
5029:Agonists:
4987:Agonists:
4959:Tadekinig
4941:Agonists:
4860:Agonists:
4834:Agonists:
4778:Agonists:
4737:Agonists:
4711:Agonists:
4685:Agonists:
4654:Agonists:
4613:Agonists:
4595:Levilimab
4585:Sirukumab
4575:Sarilumab
4532:Agonists:
4471:Agonists:
4448:Dupilumab
4415:Agonists:
4392:Muplestim
4369:Agonists:
4293:Agonists:
4220:Pifonakin
4215:Mobenakin
4198:Agonists:
3832:33/IL1F11
3797:1Ra/IL1F3
3444:IL6 like/
3161:CXCL8/IL8
2959:Chemokine
2951:By family
2944:cytokines
2659:Welham MJ
2628:CiteSeerX
2133:195122011
1980:0969-7128
1694:0340-6717
1610:1074-7613
1548:0022-2836
1494:1066-5099
1428:1066-5099
1172:platelets
1135:Discovery
1110:basophils
1050:paracrine
1042:autocrine
1007:monocytes
980:platelets
906:platelets
777:NP_000579
732:NM_000588
568:Orthologs
131:GeneCards
5354:IL-22Rα1
5320:instead.
4637:instead.
4565:mAb 1339
4550:ARGX-109
4514:TPI ASM8
4484:YM-90709
4235:Anakinra
4230:AF-12198
4063:CFU-GEMM
3949:Monokine
3478:+non IL
3363:subunit)
3361:receptor
3332:TNFSF13B
3280:TNFC/LTB
3275:TNFB/LTA
2830:30047980
2785:25068171
2362:37207637
2324:10373990
2281:35647863
2236:42948973
2199:11414705
2191:15576295
2162:14564341
1789:20592584
1740:10515681
1710:34492340
1658:36017792
1618:30995500
1588:Immunity
1556:32976908
1444:27772987
1316:37207637
1239:–
1208:See also
1198:interact
1153:antigens
1084:Receptor
926:cytokine
916:Function
894:cytokine
880:that in
845:Wikidata
547:Sources:
319:appendix
5372:IL-10Rβ
5368:IL-20Rα
5358:IL-20Rβ
5292:IL-36RA
4837:ALT-803
4129:CFU-Meg
3837:18/IL1G
3579:Type II
3511:IL12RB1
3417:β chain
3371:γ chain
3327:TNFSF13
3322:TNFSF11
3317:TNFSF10
2999:/RANTES
2903:PDBe-KB
2893:UniProt
2873:9659156
2864:1727090
2822:9629242
2802:Bibcode
2777:9551928
2742:9278420
2707:9113989
2675:Bibcode
2650:8676386
2611:8649415
2568:8516290
2536:Bibcode
2515:8018916
2480:7642615
2445:3497843
2415:3497400
2383:Bibcode
2354:3489530
2316:3127463
2273:2544122
2253:Bibcode
2228:1833064
2125:2268499
2086:7957082
2037:8649415
1988:9282170
1939:8547656
1898:7711665
1871:3087441
1830:3003517
1781:6971890
1702:8112746
1502:9766809
1436:8401260
1308:3489530
1241:Ensembl
1147:Disease
1141:T cells
1104:in the
1062:T cells
1046:T cells
1038:T cells
1034:T cells
1030:T cells
1017:(EPO),
956:B cells
949:T cells
878:protein
876:) is a
676:UniProt
633:Ensembl
574:Species
553:QuickGO
260:pattern
95:Aliases
5328:Others
5301:Others
5253:IL1RL2
5232:IL1RL1
4969:IL18BP
4240:IL-1RA
4081:CFU-GM
3827:IL1F10
3724:IFNA21
3719:IFNA17
3714:IFNA16
3709:IFNA14
3704:IFNA13
3699:IFNA10
3356:Type I
3312:TNFSF9
3307:TNFSF8
3302:TNFSF7
3297:TNFSF6
3287:TNFSF4
3222:CX3CL1
3206:CXCL17
3201:CXCL16
3196:CXCL15
3191:CXCL14
3186:CXCL13
3181:CXCL12
3176:CXCL11
3171:CXCL10
2993:/MIP1β
2987:/MIP1α
2898:P08700
2871:
2861:
2828:
2820:
2783:
2775:
2740:
2705:
2695:
2648:
2630:
2609:
2602:231298
2599:
2566:
2556:
2513:
2478:
2443:
2413:
2406:298973
2403:
2360:
2352:
2322:
2314:
2279:
2271:
2234:
2226:
2197:
2189:
2160:
2131:
2123:
2084:
2077:395466
2074:
2056:EMBO J
2035:
2028:231298
2025:
1986:
1978:
1937:
1896:
1869:
1828:
1818:
1787:
1779:
1738:
1708:
1700:
1692:
1656:
1646:
1616:
1608:
1554:
1546:
1500:
1492:
1442:
1434:
1426:
1390:
1380:
1314:
1306:
1112:, and
1095:GM-CSF
1078:GM-CSF
1009:, and
934:GM-CSF
882:humans
828:search
826:PubMed
690:P08700
590:Entrez
364:BioGPS
219:5q31.1
119:147740
5211:IL-31
5171:IL-28
5150:IL-27
5094:IL-23
5062:IL-22
5021:IL-21
4979:IL-20
4933:IL-18
4852:IL-17
4826:IL-15
4770:IL-13
4729:IL-12
4703:IL-11
4677:IL-10
4111:CFU-E
3889:KITLG
3877:Other
3863:IL17A
3822:IL1F9
3817:IL1F8
3812:IL1F7
3807:IL1F6
3802:IL1F5
3739:IFNW1
3729:IFNB1
3694:IFNA8
3689:IFNA7
3684:IFNA6
3679:IFNA5
3674:IFNA4
3669:IFNA2
3664:IFNA1
3543:Other
3446:gp130
3435:GMCSF
3215:CX3CL
3166:CXCL9
3156:CXCL7
3151:CXCL6
3146:CXCL5
3141:CXCL4
3136:CXCL3
3131:CXCL2
3125:CXCL1
3109:CCL28
3104:CCL27
3099:CCL26
3094:CCL25
3089:CCL24
3084:CCL23
3079:CCL22
3074:CCL21
3069:CCL20
3064:CCL19
3058:CCL18
3053:CCL17
3048:CCL16
3043:CCL15
3038:CCL14
3033:CCL13
3028:CCL12
3023:CCL11
2981:/MCP1
2826:S2CID
2781:S2CID
2698:20722
2559:46745
2493:Blood
2358:S2CID
2320:S2CID
2277:S2CID
2232:S2CID
2195:S2CID
2129:S2CID
1917:Blood
1849:Blood
1785:S2CID
1706:S2CID
1440:S2CID
1392:72187
1388:S2CID
1312:S2CID
1202:IL3RA
1200:with
1125:c‑myc
993:into
583:Mouse
578:Human
549:Amigo
283:Mouse
276:Human
223:Start
156:Human
127:47938
5318:here
5316:See
4646:IL-9
4635:here
4626:IL-8
4605:IL-7
4524:IL-6
4463:IL-5
4407:IL-4
4361:IL-3
4285:IL-2
4190:IL-1
4009:IL13
4004:IL10
3973:TNFβ
3968:IFNγ
3940:TNFA
3921:cell
3901:SPP1
3859:IL25
3855:IL17
3757:IFNG
3734:IFNK
3620:IL26
3615:IL24
3610:IL20
3605:IL19
3600:IL22
3596:IL10
3565:IL34
3560:IL32
3555:IL16
3550:IL14
3534:IL35
3529:IL27
3524:IL23
3519:IL12
3495:CTF1
3490:CNTF
3474:IL31
3469:IL30
3464:IL27
3459:IL11
3407:IL21
3392:IL13
3383:IL15
3265:TNFA
3243:XCL2
3238:XCL1
3118:CXCL
3018:CCL9
3013:CCL8
3008:CCL7
3003:CCL6
2997:CCL5
2991:CCL4
2985:CCL3
2979:CCL2
2974:CCL1
2891:for
2869:PMID
2818:PMID
2773:PMID
2738:PMID
2703:PMID
2646:PMID
2607:PMID
2564:PMID
2511:PMID
2476:PMID
2441:PMID
2425:Gene
2411:PMID
2350:PMID
2334:Cell
2312:PMID
2269:PMID
2224:PMID
2208:Cell
2187:PMID
2158:PMID
2121:PMID
2082:PMID
2033:PMID
1984:PMID
1976:ISSN
1935:PMID
1894:PMID
1867:PMID
1826:PMID
1816:ISBN
1777:PMID
1736:PMID
1698:PMID
1690:ISSN
1654:OCLC
1644:ISBN
1614:PMID
1606:ISSN
1552:PMID
1544:ISSN
1498:PMID
1490:ISSN
1432:PMID
1424:ISSN
1378:ISBN
1304:PMID
1288:Cell
1170:and
1070:IL-1
1054:IL-2
1023:IL-6
970:and
953:IgG+
938:IL-5
936:and
889:gene
874:IL-3
604:3562
266:Bgee
214:Band
173:Chr.
115:OMIM
72:1JLI
53:RCSB
50:PDBe
5344:CD4
5309:JAK
3999:IL6
3994:IL5
3989:IL4
3935:IL1
3906:MIF
3485:LIF
3480:OSM
3454:IL6
3430:IL5
3425:IL3
3402:IL9
3397:IL7
3388:IL4
3379:IL2
3337:EDA
3257:TNF
3231:XCL
3127:/KC
2967:CCL
2889:PDB
2859:PMC
2851:doi
2843:Gut
2810:doi
2798:840
2763:doi
2759:160
2728:doi
2724:272
2693:PMC
2683:doi
2638:doi
2624:259
2597:PMC
2589:doi
2554:PMC
2544:doi
2501:doi
2466:doi
2462:270
2433:doi
2401:PMC
2391:doi
2342:doi
2302:doi
2298:140
2261:doi
2249:554
2216:doi
2179:doi
2150:doi
2146:112
2113:doi
2072:PMC
2064:doi
2023:PMC
2015:doi
1966:doi
1925:doi
1857:doi
1808:doi
1767:doi
1763:126
1682:doi
1596:doi
1534:doi
1530:433
1480:doi
1416:doi
1370:doi
1296:doi
1060:on
886:IL3
834:n/a
819:n/a
797:n/a
752:n/a
708:n/a
665:n/a
622:n/a
339:n/a
236:End
139:OMA
135:IL3
102:IL3
43:PDB
24:IL3
5429::
5274:,
5270:,
5193:,
4885:,
4881:,
4877:,
4873:,
4869:,
4207:,
3785::
3749:II
2942::
2895::
2867:.
2857:.
2847:42
2845:.
2841:.
2824:.
2816:.
2808:.
2796:.
2779:.
2771:.
2757:.
2753:.
2736:.
2722:.
2718:.
2701:.
2691:.
2681:.
2671:94
2669:.
2665:.
2644:.
2636:.
2622:.
2605:.
2595:.
2585:16
2583:.
2579:.
2562:.
2552:.
2542:.
2532:90
2530:.
2526:.
2509:.
2497:84
2495:.
2491:.
2474:.
2460:.
2456:.
2439:.
2429:55
2427:.
2409:.
2399:.
2389:.
2379:84
2377:.
2373:.
2356:.
2348:.
2338:47
2336:.
2318:.
2310:.
2296:.
2292:.
2275:.
2267:.
2259:.
2247:.
2230:.
2222:.
2212:66
2210:.
2193:.
2185:.
2175:42
2173:.
2156:.
2144:.
2127:.
2119:.
2107:.
2080:.
2070:.
2060:13
2058:.
2054:.
2031:.
2021:.
2011:16
2009:.
2005:.
1982:.
1974:.
1960:.
1956:.
1933:.
1921:87
1919:.
1915:.
1890:14
1888:.
1865:.
1853:68
1851:.
1847:.
1824:.
1814:.
1783:.
1775:.
1761:.
1757:.
1730:.
1718:^
1704:.
1696:.
1688:.
1678:93
1676:.
1652:.
1626:^
1612:.
1604:.
1592:50
1590:.
1586:.
1564:^
1550:.
1542:.
1528:.
1524:.
1510:^
1496:.
1488:.
1476:16
1474:.
1470:.
1452:^
1438:.
1430:.
1422:.
1412:11
1410:.
1386:.
1376:.
1356:^
1335:.
1324:^
1310:.
1302:.
1292:47
1290:.
1256:.
1227:^
1204:.
1116:.
1025:.
1005:,
986:.
944:.
912:.
551:/
242:bp
229:bp
137:;
133::
129:;
125::
121:;
117::
5389:)
5370:/
5356:/
5346:)
5278:)
5276:γ
5272:β
5268:α
5266:(
5197:)
5189:(
4889:)
4887:F
4879:D
4875:C
4871:B
4867:A
4865:(
4211:)
4209:β
4205:α
4203:(
4171:e
4164:t
4157:v
4047:e
4040:t
4033:v
3984:2
3982:h
3980:T
3963:1
3961:h
3959:T
3865:)
3861:(
3857:/
3656:I
3598:/
3509:/
3390:/
3381:/
2932:e
2925:t
2918:v
2905:.
2875:.
2853::
2832:.
2812::
2804::
2787:.
2765::
2744:.
2730::
2709:.
2685::
2677::
2652:.
2640::
2613:.
2591::
2570:.
2546::
2538::
2517:.
2503::
2482:.
2468::
2447:.
2435::
2417:.
2393::
2385::
2364:.
2344::
2326:.
2304::
2283:.
2263::
2255::
2238:.
2218::
2201:.
2181::
2164:.
2152::
2135:.
2115::
2109:2
2088:.
2066::
2039:.
2017::
1990:.
1968::
1962:4
1941:.
1927::
1900:.
1873:.
1859::
1832:.
1810::
1791:.
1769::
1742:.
1732:5
1712:.
1684::
1660:.
1620:.
1598::
1558:.
1536::
1504:.
1482::
1446:.
1418::
1394:.
1372::
1350:.
1318:.
1298::
1274:.
1260:.
1048:(
872:(
158:)
141::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
