420:
3872:
397:
1922:, kills the infected cell. Pyroptosis is mediated via caspase-1 and is characterized by cell lysis and the secretion of IL-1β causing inflammation and attraction of more immune cells. This can create a cycle of CD4 T cells getting abortively infect with HIV, dying of pyroptosis, new T helper cells arriving to the site of inflammation where they get infected again. The results is the depletion of T helper cells. Even though, levels of IL-1β in blood are not majorly different between HIV positive and negative individuals, studies have shown elevated levels of IL-1β of
4157:
4142:
319:
294:
4067:
3992:
4112:
3887:
4127:
4052:
4082:
4037:
4097:
1933:) has a high density of immune cells as the gut is an interface between symbiotic gut microbes that should remain with the host and pathogenic bacteria that should not gain access into the circulatory system. If HIV-infection leads to the secretion of IL-1βin monocytes and macrophages, it causes inflammation of this area. The mucosal epithelial layer responds to this by producing less or altering the tight junction proteins which makes it easier for pathogenic microbes to move into the
3917:
3932:
3902:
426:
325:
4022:
4007:
3947:
3977:
1975:. The inflammatory reaction leads to damage of retinal cells and infiltration of cells of the immune system. The inflammatory process including NLRP3 upregulation is one of the causes of age-related macular degeneration and other retinal diseases that lead to vision loss. Additionally, it has been shown that caspase-1 is upregulated in the retina of diabetic patients, causing a higher production of IL-1β and subsequent death of retinal neurons.
4172:
3962:
31:
1914:. Secondly, CD4 T cells can be infected by the virus but instead of producing more viral particles, the cell enters a latent phase. In this period, the T helper cells looks identical from the outside but any stressor could lead to the renewed production of HIV and its propagation to new immune cells. Lastly, the T
671:
678:
1671:(interleukin 1) was purified by Dinarello in 1977 with a specific activity of 10–20 nanograms/kg. In 1979, Dinarello reported that purified human leukocytic pyrogen was the same molecule that was described by Igal Gery in 1972. He named it lymphocyte-activating factor (LAF) because it was a lymphocyte
1961:
did not have an significant effect. The role of IL-1β in age-related macular degeneration has not been proven in patient, but in many animal models and in vitro studies it has been demonstrated the role of IL-1β in retinal pigmented epithelial cells and photoreceptor cells damage. NLRP3 inflammasome
2047:
is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. Anakinra blocks the biologic activity of IL-1 alpha and beta by competitively inhibiting IL-1 binding to the interleukin type 1 receptor (IL-1RI), which is expressed in a wide variety of tissues
1868:
polymorphisms is connected to malignancies such as colon cancer and melanoma. It was reported that IL-1β secretion was elevated in the lung adenocarcinoma cell line A549. It has also been shown in another study that IL-1β, together with IL-8, plays an important role in chemoresistance of malignant
1863:
Several types of inflammasomes are suggested to play role in tumorgenesis due to their immunomodulatory properties, modulation of gut microbiota, differentiation and apoptosis. Over-expression of IL-1β caused by inflammasome may result in carcinogenesis. Some data suggest that
57:
1957:. Significantly increased protein level of IL-1β has been found in the vitreous of diabetic retinopathy patient. The role of IL-1β has been investigated for potential therapeutic target for treatment of diabetic retinopathy. However, systemic using of
3400:
Smirnova MG, Kiselev SL, Gnuchev NV, Birchall JP, Pearson JP (2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion".
3871:
4156:
4141:
2746:
Pelegrín P, García-Castillo J, Mulero V, Meseguer J (October 2001). "Interleukin-1beta isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines".
1970:
in human retina which is important for retinal metabolic activity, integrity and inhibition of immune cells infiltration. It has been shown that human retinal pigmented epithelial cells can secrete IL-1 β in exposure to
2782:
Scapigliati G, Buonocore F, Bird S, Zou J, Pelegrin P, Falasca C, et al. (November 2001). "Phylogeny of cytokines: molecular cloning and expression analysis of sea bass
Dicentrarchus labrax interleukin-1beta".
3597:
Milosevic V, Kopecka J, Salaroglio IC, Libener R, Napoli F, Izzo S, et al. (January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5".
3008:
Milosevic V, Kopecka J, Salaroglio IC, Libener R, Napoli F, Izzo S, et al. (January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5".
433:
332:
1869:
pleural mesothelioma by inducing expression of transmembrane transporters. Another study showed that inhibition of inflammasome and IL-1β expression decreased development of cancer cells in melanoma.
2029:. Consequently, microglia release interleukin-1β among other cytokines. Nevertheless, the significance of IL-1β in Alzheimer disease and the onset of neuroinflammation still remains largely unknown.
3494:
Chakravorty M, Ghosh A, Choudhury A, Santra A, Hembrum J, Roychoudhury S (February 2004). "Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India".
4066:
1760:
complex — cytosolic molecular complex — have been described. Inflammasomes recognize danger signals and activate proinflammatory process and production of IL-1β and IL-18.
1991:(MS) research, have found that blocking IL-1β could make the animals resistant to EAE. IL-1β led to the production of an antigen-specific pro-inflammatory subset of T helper cells (
2253:
March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, et al. (1985). "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs".
2036:
studies have shown that IL-1β causes an increase in mitochondrial glutaminase activity. In response, there is excessive glutamate secretion which has a neurotoxic effect.
3991:
1805:
APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
5327:
4111:
2818:
Pelegrín P, Chaves-Pozo E, Mulero V, Meseguer J (March 2004). "Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream".
3886:
5943:
4126:
1847:(a chronic autoimmune disease of the central nervous system). However, it is not known exactly which cells produce IL-1β. Treatment of multiple sclerosis with
3880:: THE STRUCTURE OF AN INTERLEUKIN-1 BETA MUTANT WITH REDUCED BIOACTIVITY SHOWS MULTIPLE SUBTLE CHANGES IN CONFORMATION THAT AFFECT PROTEIN-PROTEIN RECOGNITION
4051:
5453:
2545:
Gery I, Handschumacher RE (March 1974). "Potentiation of the T lymphocyte response to mitogens. III. Properties of the mediator(s) from adherent cells".
4081:
4036:
1351:
6565:
1872:
Furthermore, it has been found that in breast cancer cells, IL-1β activates p38 and p42/22 MAPK pathways which ultimately lead to the secretion of the
1332:
6339:
255:
6348:
4165:: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN-1 BETA IN SOLUTION BY THREE-AND FOUR-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
4150:: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN-1 BETA IN SOLUTION BY THREE-AND FOUR-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
4096:
2049:
5478:
4716:
3213:"NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration"
1999:
1753:. This induction of expression is in the absence of additional signals. That suggests IL-1β is involved in modulation of autoimmune inflammation
5897:
5692:
6209:
6204:
3560:
Maruyama Y, Stenvinkel P, Lindholm B (2005). "Role of interleukin-1beta in the development of malnutrition in chronic renal failure patients".
3164:"Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1β and MCP-1 in cultured human retinal pigment epithelial cells"
6189:
6101:
6080:
5529:
5463:
5422:
5320:
4788:
3916:
2172:
2154:
6070:
5938:
5845:
5824:
5575:
5544:
5539:
5483:
5402:
1903:). The latter can be infected by the virus in various ways with different fates depending on the state of activation of the T helper cell.
6116:
5549:
5377:
5372:
5722:
5707:
5671:
5641:
5387:
3931:
3819:
1551:
1558:
1984:
1966:
which catalyze cleavage of inactive cytosolic precursor pro-IL-1β to its mature form IL-1β. Retinal pigmented epithelial cells forms
3901:
1772:) type of inflammasome is activated by various stimuli and there are documented several diseases connected to NLRP3 activation like
5313:
1810:
The physiological activity determined from the dose dependent proliferation of murine D10S cells is 2.5 x 10 to 7.1 x 10 units/mg.
3762:
Kamangar F, Cheng C, Abnet CC, Rabkin CS (October 2006). "Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis".
6036:
6032:
6028:
4792:
2632:
1813:
IL-1β is present in other species of animals, however non-mammalian sequences of IL-1β lack a conserved cascase-1 cleavage site.
6525:
5792:
5187:
2059:
1826:
2589:
Yaseen MM, Abuharfeil NM, Darmani H (January 2023). "The role of IL-1β during human immunodeficiency virus type 1 infection".
6529:
6515:
6475:
3851:
2306:"Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene"
2648:"Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity"
2137:
6590:
6544:
54:
3424:"Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease"
1884:. Higher osteoprotegerin and IL-1β levels are a characteristic of breast cancer cells with a higher metastatic potential.
4212:
2116:
2018:
1918:
cell can become abortively infected, where the virus gets detected inside the cell and a programmed cell-death, known as
1800:. The molecular weight of the proteolytically processed IL-1β is 17.5 kDa. IL-1β has the following amino acid sequence:
6449:
5397:
5078:
2699:"NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases"
419:
4608:
2141:
2120:
396:
1945:
It has been shown that IL-1 family plays important role in inflammation in many degenerative diseases, such as
1930:
1396:
2353:
Bensi G, Raugei G, Palla E, Carinci V, Tornese
Buonamassa D, Melli M (1987). "Human interleukin-1 beta gene".
6410:
6389:
4385:
4021:
4006:
4075:: Determination of Solvent Content in Cavities in Interleukin-1 Using Experimentally-Phased Electron Density
3946:
2498:"Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s)"
1377:
2022:
318:
293:
235:
3367:
1710:, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and
1675:. It was not until 1984 that interleukin 1 was discovered to consist of two distinct proteins, now called
5221:
4771:
4546:
3976:
2961:"New Insights into the Role of IL-1β in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis"
3262:"IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases"
1896:(HIV) infects cells of the immune system, such as macrophages, dendritic cells, and CD4 T helper cells (
5254:
5056:
4766:
2096:(because ß transcodes to ss). This is why so many mentions of the latter appear in web search results.
1822:
1726:
hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on
432:
331:
4171:
3961:
3531:
Joseph AM, Kumar M, Mitra D (January 2005). "Nef: "necessary and enforcing factor" in HIV infection".
2002:
which is correlated to neuroinflammation. Detailed mechanisms on this front are yet to be elucidated.
5175:
4860:
3844:
1998:). In combination with other cytokines, interleukin-1β can upregulate the production of the cytokine
1967:
1937:. Here, the pathogens can further activate local immune cells and amplify the inflammatory response.
1773:
425:
324:
222:
5210:
4637:
4613:
3810:
243:
2058:
is a human monoclonal antibody targeted at IL-1B, and approved in many countries for treatment of
6368:
6328:
6307:
6251:
6219:
6178:
6136:
6090:
6009:
5983:
5927:
5886:
5860:
5834:
5488:
4205:
3806:
2902:
Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, et al. (December 2014).
1534:
1513:
1487:
1466:
5803:
5783:
5762:
5681:
5620:
5564:
5518:
5442:
5347:
4538:
2010:
1777:
1719:
3688:
Copeland KF (December 2005). "Modulation of HIV-1 transcription by cytokines and chemokines".
3211:
Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR (January 2013).
6595:
4000:: Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan.
2870:
2190:
Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA (December 1984).
1707:
2697:
Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Rouis M (April 2015).
5336:
5064:
3837:
2915:
2401:
2262:
2203:
1954:
1950:
1946:
1702:
known as slanDC, as a proprotein, which is proteolytically processed to its active form by
1683:
307:
1829:, due to mutations in the inflammasome receptor NLRP3 which triggers processing of IL-1β.
263:
8:
5468:
5362:
4906:
2855:"Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)"
2006:
1769:
1676:
2919:
2405:
2266:
2207:
1910:
cells can die of viral lysis due to an active infection that produces enough virions to
5339:
5030:
4945:
4652:
4198:
4120:: FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE
3787:
3745:
3718:
3676:
3633:
3585:
3519:
3448:
3423:
3344:
3319:
3288:
3261:
3237:
3212:
3188:
3163:
3139:
3114:
3090:
3063:
3044:
2985:
2960:
2936:
2903:
2879:
2854:
2723:
2698:
2614:
2522:
2497:
2473:
2448:
2286:
2048:
and organs. Anakinra is marketed as
Kineret and is approved in the US for treatment of
1988:
1865:
1848:
1844:
267:
3895:: CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-1BETA AT 2.0 ANGSTROMS RESOLUTION
3478:
2424:
2389:
2330:
2305:
2226:
2191:
1266:
1261:
1256:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1216:
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1201:
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1151:
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1141:
1136:
1131:
1126:
1121:
1116:
1111:
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1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
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921:
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886:
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871:
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861:
856:
851:
846:
841:
836:
831:
826:
821:
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811:
806:
790:
785:
780:
775:
770:
765:
760:
755:
739:
734:
729:
724:
719:
4937:
4556:
4422:
3779:
3750:
3705:
3668:
3637:
3625:
3577:
3548:
3511:
3482:
3453:
3410:
3349:
3293:
3242:
3193:
3144:
3095:
3048:
3036:
2990:
2941:
2884:
2835:
2800:
2764:
2728:
2679:
2618:
2606:
2562:
2558:
2527:
2478:
2429:
2370:
2366:
2335:
2278:
2231:
215:
47:
3680:
3589:
1007:
positive regulation of vascular endothelial growth factor receptor signaling pathway
6560:
5249:
5170:
5038:
4727:
4561:
4135:: A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B
3791:
3771:
3740:
3730:
3697:
3658:
3615:
3607:
3569:
3540:
3523:
3503:
3474:
3443:
3435:
3339:
3331:
3283:
3273:
3232:
3224:
3183:
3175:
3134:
3126:
3085:
3075:
3026:
3018:
2980:
2972:
2931:
2923:
2874:
2866:
2827:
2792:
2756:
2718:
2710:
2669:
2659:
2598:
2554:
2517:
2509:
2468:
2460:
2419:
2409:
2362:
2325:
2317:
2290:
2270:
2221:
2211:
1992:
1972:
1923:
512:
443:
387:
342:
5305:
3775:
2646:
Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH (August 2009).
982:
positive regulation of granulocyte macrophage colony-stimulating factor production
247:
6352:
4776:
4462:
2664:
2647:
2014:
1881:
1785:
1668:
1107:
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
487:
271:
2714:
2177:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2159:
National Center for
Biotechnology Information, U.S. National Library of Medicine
6550:
6540:
6535:
6521:
6507:
6497:
6492:
6439:
6421:
6400:
6379:
6358:
6344:
6318:
6262:
6230:
6194:
6157:
6152:
6147:
6111:
6106:
6020:
5999:
5953:
5902:
5871:
5850:
5585:
5554:
5290:
5285:
5140:
5136:
5118:
5113:
4916:
4911:
4901:
4896:
4891:
4886:
4881:
4877:
4846:
4841:
4836:
4815:
4810:
4805:
4800:
4755:
4750:
4745:
4740:
4688:
4673:
4664:
4221:
4060:: CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN-1 BETA AT 2.0 ANGSTROMS RESOLUTION
3701:
3179:
2449:"Potentiation of the T-lymphocyte response to mitogens. I. The responding cell"
2394:
Proceedings of the
National Academy of Sciences of the United States of America
2196:
Proceedings of the
National Academy of Sciences of the United States of America
2080:
Because many authors of scientific manuscripts make the minor error of using a
1934:
1750:
1746:
1742:
1738:
1734:
1699:
588:
3335:
3080:
2831:
2390:"Human leukocytic pyrogen: purification and development of a radioimmunoassay"
6584:
6292:
5948:
5814:
5773:
5697:
5631:
5580:
5534:
5473:
5358:
5280:
5275:
5270:
5216:
5165:
4831:
4735:
4711:
4706:
4683:
4678:
4669:
4660:
4442:
3823:
3735:
3544:
3278:
2976:
2321:
1897:
1837:
1797:
1648:
706:
4190:
4090:: INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY SER) (C71S)
4045:: INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY ALA) (C71A)
3062:
Moossavi M, Parsamanesh N, Bahrami A, Atkin SL, Sahebkar A (November 2018).
2414:
2216:
648:
526:
6466:
6287:
5973:
5968:
5963:
5712:
5651:
5610:
4761:
4593:
3783:
3754:
3709:
3672:
3647:"Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells"
3629:
3581:
3552:
3515:
3486:
3457:
3414:
3353:
3297:
3246:
3197:
3148:
3099:
3040:
2994:
2945:
2888:
2839:
2804:
2796:
2768:
2760:
2732:
2683:
2610:
1765:
1757:
1727:
505:
284:
3507:
3228:
2566:
2531:
2513:
2482:
2464:
2374:
2339:
2282:
2235:
1598:
1593:
6297:
6277:
6240:
6075:
6065:
5917:
5912:
5747:
5717:
5656:
5498:
5458:
5417:
5412:
5182:
5128:
4869:
4628:
4551:
4105:: INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 8 REPLACED BY ALA (C8A)
3439:
2093:
2055:
1958:
1911:
1852:
1441:
1422:
3620:
3130:
3031:
2927:
2433:
670:
6282:
6272:
6167:
6060:
6055:
5876:
5737:
5727:
5661:
5595:
5508:
5503:
5432:
5235:
4928:
4618:
4578:
2904:"Dietary modulation of the microbiome affects autoinflammatory disease"
2065:
1919:
1691:
1652:
677:
404:
301:
251:
3611:
3573:
3022:
2674:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
5752:
5742:
5732:
5605:
4240:
2745:
2602:
2274:
2081:
2069:
2026:
1963:
1855:
has also been shown to reduce the presence of IL-1β or its receptor.
1833:
1796:
Before cleavage by caspase 1, pro-IL-1β has a molecular weight of 37
1711:
1703:
1656:
1296:
471:
458:
370:
357:
259:
2192:"Nucleotide sequence of human monocyte interleukin 1 precursor cDNA"
1102:
positive regulation of vascular endothelial growth factor production
5392:
5230:
4225:
3465:
Arend WP (2003). "The balance between IL-1 and IL-1Ra in disease".
3260:
Wooff Y, Man SM, Aggio-Bruce R, Natoli R, Fernando N (2019-07-16).
2251:"Catabolin" is the name given by Jeremy Saklatvala for IL-1 alpha.
2044:
1695:
1687:
1655:
and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic
1634:
1582:
2304:
Clark BD, Collins KL, Gandy MS, Webb AC, Auron PE (October 1986).
6511:
5994:
3925:: TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA
3663:
3646:
3596:
3162:
Bian ZM, Field MG, Elner SG, Kahlenberg JM, Elner VM (May 2018).
3007:
2817:
2696:
1781:
1672:
1637:
1408:
1363:
1281:
1277:
2852:
2092:(β), mentions of "IL-1ß" often become "IL-1ss" upon automated
1042:
positive regulation of monocyte chemotactic protein-1 production
962:
positive regulation of DNA-binding transcription factor activity
239:
6126:
5108:
5005:
5000:
4995:
4990:
4985:
4980:
4698:
4503:
4487:
4482:
4477:
4472:
4467:
4457:
4452:
3493:
3061:
1566:
1318:
686:
3829:
3399:
1052:
positive regulation of membrane protein ectodomain proteolysis
977:
positive regulation of NF-kappaB transcription factor activity
6433:
6429:
6425:
6044:
6040:
6024:
5144:
5103:
5098:
5093:
5088:
5083:
5020:
5010:
4975:
4970:
4965:
4960:
4955:
4950:
4603:
4598:
4588:
4573:
4568:
4447:
4437:
4432:
4427:
4417:
4412:
4406:
4390:
4380:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
1877:
1761:
1715:
5068:
5015:
4583:
4524:
4519:
4299:
4294:
4289:
4284:
4278:
4272:
4266:
4260:
4255:
3940:: Crystal structure of Interleukin 1-beta F42W/W120F mutant
2781:
2089:
1873:
1843:
The presence of IL-1β has been also found in patients with
1821:
Increased production of IL-1β causes a number of different
1723:
1706:(CASP1/ICE). This cytokine is an important mediator of the
1644:
1172:
positive regulation of epithelial to mesenchymal transition
3559:
3210:
2645:
2085:
1242:
positive regulation of T-helper 1 cell cytokine production
1097:
positive regulation of I-kappaB kinase/NF-kappaB signaling
1092:
extrinsic apoptotic signaling pathway in absence of ligand
6501:
3719:"H pylori and gastric cancer: shifting the global burden"
3259:
2853:
Masters SL, Simon A, Aksentijevich I, Kastner DL (2009).
2252:
2189:
1893:
1247:
positive regulation of prostaglandin biosynthetic process
1137:
positive regulation of transcription by RNA polymerase II
902:
positive regulation of myosin light chain kinase activity
822:
negative regulation of insulin receptor signaling pathway
817:
positive regulation of calcidiol 1-monooxygenase activity
3910:: INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT
3761:
3161:
2901:
1032:
positive regulation of nitric oxide biosynthetic process
1012:
positive regulation of cell adhesion molecule production
495:
2588:
2352:
2005:
IL-1β has also been observed in elevated levels of the
1825:, most notably the monogenic conditions referred to as
30:
1659:(interleukin 1 beta convertase) to form mature IL-1β.
1077:
negative regulation of glucose transmembrane transport
2303:
2072:
targeting IL-1B, and approved in the US as
Arcalyst.
942:
positive regulation of heterotypic cell-cell adhesion
660:
3115:"The role of IL-1B in breast cancer bone metastasis"
2387:
2017:, that are characteristic of Alzheimer disease, are
1162:
positive regulation of cell population proliferation
857:
negative regulation of cell population proliferation
226:, IL-1, IL1-BETA, IL1F2, interleukin 1 beta, IL1beta
5335:
3716:
3320:"The IL-1β phenomena in neuroinflammatory diseases"
887:
positive regulation of transcription, DNA-templated
2544:
2446:
2133:
2131:
2129:
2112:
2110:
2108:
1122:regulation of establishment of endothelial barrier
1057:positive regulation of interferon-gamma production
892:positive regulation of protein export from nucleus
2388:Dinarello CA, Renfer L, Wolff SM (October 1977).
1667:The fever-producing property of human leukocytic
1227:positive regulation of neuroinflammatory response
852:regulation of I-kappaB kinase/NF-kappaB signaling
442:
341:
6582:
3764:Cancer Epidemiology, Biomarkers & Prevention
3717:Prinz C, Schwendy S, Voland P (September 2006).
3530:
3313:
3311:
3309:
3307:
3217:Investigative Ophthalmology & Visual Science
3317:
3112:
2126:
2105:
1267:positive regulation of RNA biosynthetic process
1207:positive regulation of glial cell proliferation
1147:regulation of defense response to virus by host
1087:positive regulation of T cell mediated immunity
917:positive regulation of interleukin-6 production
837:positive regulation of mitotic nuclear division
832:positive regulation of interleukin-8 production
3644:
2584:
2582:
2580:
2578:
2576:
2138:GRCm38: Ensembl release 89: ENSMUSG00000027398
1827:Cryopyrin-Associated Periodic Syndromes (CAPS)
1237:positive regulation of NIK/NF-kappaB signaling
1112:negative regulation of lipid catabolic process
947:positive regulation of lipid catabolic process
927:negative regulation of lipid metabolic process
897:positive regulation of prostaglandin secretion
807:positive regulation of protein phosphorylation
5321:
4220:
4206:
3845:
3304:
2247:
2245:
1929:In fact, the gut-associated lymphoid tissue (
1722:(CNS) is found to contribute to inflammatory
1002:lipopolysaccharide-mediated signaling pathway
3001:
2846:
2447:Gery I, Gershon RK, Waksman BH (July 1972).
1257:positive regulation of inflammatory response
1252:positive regulation of complement activation
1202:negative regulation of synaptic transmission
1117:negative regulation of adiponectin secretion
1047:regulation of nitric-oxide synthase activity
952:cellular response to organic cyclic compound
3421:
2573:
2538:
2495:
2117:GRCh38: Ensembl release 89: ENSG00000125538
912:positive regulation of T cell proliferation
5328:
5314:
4213:
4199:
3852:
3838:
3820:United States National Library of Medicine
3064:"Role of the NLRP3 inflammasome in cancer"
2958:
2346:
2297:
2242:
2183:
2039:
1067:positive regulation of histone acetylation
907:negative regulation of MAP kinase activity
3809:at the U.S. National Library of Medicine
3744:
3734:
3662:
3645:Roy D, Sarkar S, Felty Q (January 2006).
3619:
3447:
3343:
3287:
3277:
3236:
3187:
3138:
3089:
3079:
3030:
2984:
2935:
2878:
2722:
2673:
2663:
2521:
2472:
2423:
2413:
2329:
2225:
2215:
1985:experimental autoimmune encephalomyelitis
1858:
1690:. This cytokine is produced by activated
1167:regulation of signaling receptor activity
6493:Interleukin 14 (taxilin alpha, HMW-BCGF)
3818:This article incorporates text from the
3687:
2871:10.1146/annurev.immunol.25.022106.141627
2820:Developmental and Comparative Immunology
2381:
1816:
1217:interleukin-1-mediated signaling pathway
827:cellular response to mechanical stimulus
3368:"ARCALYSTTM (rilonacept) Product Label"
2633:"Entrez Gene: IL1B interleukin 1, beta"
2060:cryopyrin-associated periodic syndromes
1940:
1222:cellular response to lipopolysaccharide
992:ectopic germ cell programmed cell death
957:positive regulation of fever generation
16:Mammalian protein found in Homo sapiens
6583:
5791:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
1887:
1232:positive regulation of p38MAPK cascade
1072:positive regulation of gene expression
867:cellular response to organic substance
5309:
4194:
3833:
3464:
2025:(PRRs) and lead to the activation of
1718:(PTGS2/COX2) by this cytokine in the
1177:positive regulation of cell migration
447:
408:
403:
346:
305:
300:
3467:Cytokine & Growth Factor Reviews
3318:Mendiola AS, Cardona AE (May 2018).
2502:The Journal of Experimental Medicine
2453:The Journal of Experimental Medicine
2075:
2019:damage-associated molecular patterns
1978:
1768:, a nucleotide-binding domain and a
1127:positive regulation of cell division
3690:Mini Reviews in Medicinal Chemistry
3422:Griffin WS, Mrak RE (August 2002).
3377:. U.S. Food and Drug Administration
3113:Tulotta C, Ottewell P (July 2018).
1212:regulation of ERK1 and ERK2 cascade
1197:negative regulation of neurogenesis
1142:cytokine-mediated signaling pathway
967:positive regulation of angiogenesis
872:positive regulation of phagocytosis
13:
3392:
1840:through a IL-1β dependent manner.
1157:positive regulation of JNK cascade
14:
6607:
4030:: Interleukin-1 Beta Mutant F146Y
4015:: INTERLEUKIN 1 BETA MUTANT F101Y
3800:
3723:World Journal of Gastroenterology
1640:that in humans is encoded by the
4170:
4155:
4140:
4125:
4110:
4095:
4080:
4065:
4050:
4035:
4020:
4005:
3990:
3975:
3960:
3955:: Interleukin 1 beta mutant F42W
3945:
3930:
3915:
3900:
3885:
3870:
2959:Lin CC, Edelson BT (June 2017).
2496:Gery I, Waksman BH (July 1972).
1947:age-related macular degeneration
676:
669:
631:lumbar subsegment of spinal cord
431:
424:
418:
395:
330:
323:
317:
292:
29:
6319:Interleukin 27 (interleukin 30)
3859:
3600:International Journal of Cancer
3360:
3253:
3204:
3155:
3106:
3055:
3011:International Journal of Cancer
2952:
2895:
2811:
2785:Fish & Shellfish Immunology
2775:
2739:
2690:
2639:
2625:
2489:
2440:
2021:(DAMPs) that are recognized by
937:hyaluronan biosynthetic process
877:regulation of insulin secretion
720:protein domain specific binding
3375:Regeneron Pharmaceuticals, Inc
3324:Journal of Neural Transmission
2165:
2147:
1623:leukocytic endogenous mediator
972:response to lipopolysaccharide
725:interleukin-1 receptor binding
687:More reference expression data
649:More reference expression data
1:
3985:: Interleukin 1B Mutant F146W
3776:10.1158/1055-9965.EPI-06-0267
3479:10.1016/S1359-6101(02)00020-5
2099:
2068:is an IL-1 trap developed by
2023:pattern recognition receptors
1926:in HIV-infected individuals.
1791:
1082:interleukin-1 beta production
416:
315:
3428:Journal of Leukocyte Biology
2665:10.1016/j.immuni.2009.08.001
2559:10.1016/0008-8749(74)90016-1
2367:10.1016/0378-1119(87)90398-2
1894:human immunodeficiency virus
1836:has been observed to induce
1631:lymphocyte activating factor
932:sequestering of triglyceride
7:
6591:Genes on human chromosome 2
5669:Antisense oligonucleotides:
2859:Annual Review of Immunology
2715:10.1016/j.redox.2015.01.008
2591:Reviews in Medical Virology
1733:IL-1β, in combination with
1662:
10:
6612:
4180:: HUMAN INTERLEUKIN-1 BETA
3970:: Interleukin 1 beta F101W
3702:10.2174/138955705774933383
3180:10.1016/j.exer.2018.02.014
1823:autoinflammatory syndromes
1647:. There are two genes for
1192:regulation of neurogenesis
1027:protein kinase B signaling
6485:
6465:
6458:
6409:
6388:
6367:
6327:
6306:
6250:
6218:
6177:
6135:
6089:
6008:
5982:
5926:
5885:
5859:
5833:
5802:
5782:
5761:
5680:
5619:
5563:
5517:
5441:
5346:
5200:
5176:Colony-stimulating factor
5158:
5127:
5055:
5029:
4936:
4927:
4868:
4859:
4824:
4787:
4725:
4697:
4651:
4636:
4627:
4537:
4512:
4496:
4399:
4248:
4239:
4232:
3865:
3403:European Cytokine Network
3336:10.1007/s00702-017-1732-9
3168:Experimental Eye Research
3081:10.1186/s12943-018-0900-3
2832:10.1016/j.dci.2003.08.002
2173:"Mouse PubMed Reference:"
2155:"Human PubMed Reference:"
1764:(contains three domain:
1682:IL-1β is a member of the
1597:
1592:
1588:
1581:
1565:
1559:Chr 2: 129.21 – 129.21 Mb
1552:Chr 2: 112.83 – 112.84 Mb
1546:
1531:
1527:
1510:
1506:
1499:
1484:
1480:
1463:
1459:
1452:
1439:
1435:
1420:
1416:
1407:
1394:
1390:
1375:
1371:
1362:
1349:
1345:
1330:
1326:
1317:
1302:
1295:
1291:
1275:
1262:response to interleukin-1
705:
701:
684:
668:
659:
646:
595:
586:
533:
524:
494:
486:
482:
465:
452:
415:
394:
385:
381:
364:
351:
314:
291:
282:
278:
233:
230:
220:
213:
208:
73:
68:
51:
46:
41:
37:
28:
23:
5211:proinflammatory cytokine
3811:Medical Subject Headings
3736:10.3748/wjg.v12.i34.5458
3545:10.2174/1570162052773013
3279:10.3389/fimmu.2019.01618
3119:Endocrine-Related Cancer
2977:10.4049/jimmunol.1700263
1774:type 2 diabetes mellitus
1737:, induced expression of
1679:and interleukin-1 beta.
1182:interleukin-6 production
842:response to carbohydrate
812:smooth muscle adaptation
6359:Interleukin-29 (IFN-λ1)
5504:Daclizumab (dacliximab)
5489:Tucotuzumab celmoleukin
3651:Frontiers in Bioscience
3266:Frontiers in Immunology
2415:10.1073/pnas.74.10.4624
2217:10.1073/pnas.81.24.7907
2040:As a therapeutic target
1627:mononuclear cell factor
6340:Interferon λ4 (IFN-λ4)
5433:Rilonacept (IL-1 Trap)
4342:/PARC/DCCK1/AMAC1/MIP4
2797:10.1006/fsim.2001.0347
2761:10.1006/cyto.2001.0949
2322:10.1093/nar/14.20.7897
2310:Nucleic Acids Research
1859:Role in carcinogenesis
1720:central nervous system
1633:and other names, is a
561:pancreatic ductal cell
6263:Interleukin 23 (SGRF)
5944:Cintredekin besudotox
5872:Interleukin 11 (AGIF)
5851:Interleukin 10 (CSIF)
3508:10.1353/hub.2004.0016
3229:10.1167/iovs.12-10655
2965:Journal of Immunology
2514:10.1084/jem.136.1.143
2465:10.1084/jem.136.1.128
2009:and brain tissues of
1968:blood retinal barrier
1817:Clinical significance
1708:inflammatory response
922:inflammatory response
882:neutrophil chemotaxis
776:extracellular exosome
5337:Interleukin receptor
3533:Current HIV Research
3440:10.1189/jlb.72.2.233
1955:retinitis pigmentosa
1951:diabetic retinopathy
1941:Retinal degeneration
1684:interleukin 1 family
1187:astrocyte activation
1022:monocyte aggregation
766:extracellular region
449:2 F1|2 62.97 cM
410:Chromosome 2 (mouse)
308:Chromosome 2 (human)
69:List of PDB id codes
42:Available structures
5469:Denileukin diftitox
4907:Interferon type III
3807:IL1B+protein,+human
3131:10.1530/ERC-17-0309
2928:10.1038/nature13788
2920:2014Natur.516..246L
2547:Cellular Immunology
2406:1977PNAS...74.4624D
2267:1985Natur.315..641M
2208:1984PNAS...81.7907A
2007:cerebrospinal fluid
1987:(EAE), a model for
1983:Studies in mice on
1888:In HIV-1 infections
1778:Alzheimer's disease
1770:leucine-rich repeat
1714:. The induction of
1677:interleukin-1 alpha
1132:signal transduction
1037:cell-cell signaling
997:leukocyte migration
847:embryo implantation
791:extracellular space
623:islet of Langerhans
6041:E (interleukin 25)
3822:, which is in the
3562:Blood Purification
1989:multiple sclerosis
1866:NLRP3 inflammasome
1849:glatiramer acetate
1845:multiple sclerosis
1698:, and a subset of
1619:leukocytic pyrogen
1611:Interleukin-1 beta
1397:ENSMUSG00000027398
800:Biological process
749:Cellular component
713:Molecular function
607:tibiofemoral joint
6578:
6577:
6574:
6573:
6543:(signals through
6524:(signals through
6510:(signals through
6500:(signals through
6124:Binding proteins:
5454:Adargileukin alfa
5303:
5302:
5196:
5195:
5154:
5153:
5051:
5050:
5047:
5046:
4855:
4854:
4533:
4532:
4188:
4187:
3770:(10): 1920–1928.
3729:(34): 5458–5464.
3696:(12): 1093–1101.
3612:10.1002/ijc.32419
3574:10.1159/000086012
3023:10.1002/ijc.32419
2971:(12): 4553–4560.
2914:(7530): 246–249.
2400:(10): 4624–4627.
2316:(20): 7897–7914.
2261:(6021): 641–647.
2202:(24): 7907–7911.
2076:Orthographic note
2015:amyloid-β plaques
1979:Neuroinflammation
1608:
1607:
1604:
1603:
1577:
1576:
1542:
1541:
1521:
1520:
1495:
1494:
1474:
1473:
1448:
1447:
1429:
1428:
1403:
1402:
1384:
1383:
1358:
1357:
1339:
1338:
1287:
1286:
862:apoptotic process
781:secretory granule
730:cytokine activity
697:
696:
693:
692:
655:
654:
642:
641:
580:
579:
553:bone marrow cells
537:periodontal fiber
478:
477:
377:
376:
204:
203:
200:
199:
52:Ortholog search:
6603:
6566:Efineptakin alfa
6561:Efavaleukin alfa
6463:
6462:
5430:Decoy receptors:
5330:
5323:
5316:
5307:
5306:
4934:
4933:
4866:
4865:
4649:
4648:
4634:
4633:
4246:
4245:
4237:
4236:
4215:
4208:
4201:
4192:
4191:
4174:
4159:
4144:
4129:
4114:
4099:
4084:
4069:
4054:
4039:
4024:
4009:
3994:
3979:
3964:
3949:
3934:
3919:
3904:
3889:
3874:
3854:
3847:
3840:
3831:
3830:
3795:
3758:
3748:
3738:
3713:
3684:
3666:
3641:
3623:
3593:
3556:
3527:
3490:
3473:(4–5): 323–340.
3461:
3451:
3418:
3387:
3386:
3384:
3382:
3372:
3364:
3358:
3357:
3347:
3315:
3302:
3301:
3291:
3281:
3257:
3251:
3250:
3240:
3208:
3202:
3201:
3191:
3159:
3153:
3152:
3142:
3125:(7): R421–R434.
3110:
3104:
3103:
3093:
3083:
3068:Molecular Cancer
3059:
3053:
3052:
3034:
3005:
2999:
2998:
2988:
2956:
2950:
2949:
2939:
2899:
2893:
2892:
2882:
2850:
2844:
2843:
2815:
2809:
2808:
2779:
2773:
2772:
2743:
2737:
2736:
2726:
2694:
2688:
2687:
2677:
2667:
2643:
2637:
2636:
2629:
2623:
2622:
2603:10.1002/rmv.2400
2586:
2571:
2570:
2553:(1–3): 162–169.
2542:
2536:
2535:
2525:
2493:
2487:
2486:
2476:
2444:
2438:
2437:
2427:
2417:
2385:
2379:
2378:
2350:
2344:
2343:
2333:
2301:
2295:
2294:
2275:10.1038/315641a0
2249:
2240:
2239:
2229:
2219:
2187:
2181:
2180:
2169:
2163:
2162:
2151:
2145:
2135:
2124:
2114:
2088:(ß), instead of
1973:oxidative stress
1924:lymphatic tissue
1806:
1716:cyclooxygenase-2
1617:) also known as
1590:
1589:
1561:
1554:
1537:
1525:
1524:
1516:
1504:
1503:
1500:RefSeq (protein)
1490:
1478:
1477:
1469:
1457:
1456:
1433:
1432:
1414:
1413:
1388:
1387:
1369:
1368:
1343:
1342:
1324:
1323:
1293:
1292:
1152:fever generation
735:integrin binding
703:
702:
689:
680:
673:
666:
665:
651:
591:
589:Top expressed in
584:
583:
557:cartilage tissue
529:
527:Top expressed in
522:
521:
501:
500:
484:
483:
474:
461:
450:
435:
428:
422:
411:
399:
383:
382:
373:
360:
349:
334:
327:
321:
310:
296:
280:
279:
274:
272:IL1B - orthologs
225:
218:
195:
66:
65:
60:
39:
38:
33:
21:
20:
6611:
6610:
6606:
6605:
6604:
6602:
6601:
6600:
6581:
6580:
6579:
6570:
6481:
6454:
6405:
6384:
6363:
6323:
6302:
6246:
6243:(against IL-22)
6214:
6173:
6170:(against IL-20)
6131:
6085:
6004:
5978:
5922:
5881:
5855:
5829:
5798:
5778:
5757:
5676:
5615:
5559:
5513:
5437:
5342:
5334:
5304:
5299:
5265:
5244:
5202:
5192:
5150:
5123:
5043:
5025:
4923:
4851:
4820:
4783:
4721:
4693:
4644:
4642:
4640:
4623:
4529:
4508:
4492:
4395:
4228:
4219:
4189:
4184:
4181:
4175:
4166:
4160:
4151:
4145:
4136:
4130:
4121:
4115:
4106:
4100:
4091:
4085:
4076:
4070:
4061:
4055:
4046:
4040:
4031:
4025:
4016:
4010:
4001:
3995:
3986:
3980:
3971:
3965:
3956:
3950:
3941:
3935:
3926:
3920:
3911:
3905:
3896:
3890:
3881:
3875:
3861:
3858:
3803:
3798:
3395:
3393:Further reading
3390:
3380:
3378:
3370:
3366:
3365:
3361:
3316:
3305:
3258:
3254:
3209:
3205:
3160:
3156:
3111:
3107:
3060:
3056:
3006:
3002:
2957:
2953:
2900:
2896:
2851:
2847:
2816:
2812:
2780:
2776:
2744:
2740:
2695:
2691:
2644:
2640:
2631:
2630:
2626:
2587:
2574:
2543:
2539:
2494:
2490:
2445:
2441:
2386:
2382:
2351:
2347:
2302:
2298:
2250:
2243:
2188:
2184:
2171:
2170:
2166:
2153:
2152:
2148:
2136:
2127:
2115:
2106:
2102:
2078:
2050:RA, NOMID, DIRA
2042:
1996:
1981:
1943:
1917:
1909:
1901:
1890:
1882:osteoprotegerin
1861:
1819:
1804:
1794:
1786:atherosclerosis
1700:dendritic cells
1665:
1599:View/Edit Mouse
1594:View/Edit Human
1557:
1550:
1547:Location (UCSC)
1533:
1512:
1486:
1465:
1378:ENSG00000125538
1271:
1017:response to ATP
987:immune response
795:
744:
740:protein binding
685:
675:
674:
647:
638:
635:right ventricle
633:
629:
625:
621:
617:
613:
609:
605:
601:
587:
576:
571:
567:
563:
559:
555:
551:
547:
543:
539:
525:
469:
456:
448:
438:
437:
436:
429:
409:
386:Gene location (
368:
355:
347:
337:
336:
335:
328:
306:
283:Gene location (
234:
221:
214:
75:
53:
17:
12:
11:
5:
6609:
6599:
6598:
6593:
6576:
6575:
6572:
6571:
6569:
6568:
6563:
6554:
6553:
6551:Interleukin 35
6548:
6541:Interleukin 34
6538:
6536:Interleukin 32
6533:
6522:Interleukin 26
6519:
6508:Interleukin 24
6505:
6498:Interleukin 16
6495:
6489:
6487:
6483:
6482:
6480:
6479:
6471:
6469:
6460:
6456:
6455:
6453:
6452:
6443:
6442:
6440:Interleukin 38
6437:
6422:Interleukin 36
6415:
6413:
6407:
6406:
6404:
6403:
6401:Interleukin 33
6394:
6392:
6386:
6385:
6383:
6382:
6380:Interleukin 31
6373:
6371:
6365:
6364:
6362:
6361:
6356:
6345:Interleukin 28
6342:
6333:
6331:
6325:
6324:
6322:
6321:
6312:
6310:
6304:
6303:
6301:
6300:
6295:
6290:
6285:
6280:
6275:
6266:
6265:
6256:
6254:
6248:
6247:
6245:
6244:
6234:
6233:
6231:Interleukin 22
6224:
6222:
6216:
6215:
6213:
6212:
6207:
6198:
6197:
6195:Interleukin 21
6192:
6183:
6181:
6175:
6174:
6172:
6171:
6161:
6160:
6158:Interleukin 24
6155:
6153:Interleukin 20
6150:
6148:Interleukin 19
6141:
6139:
6133:
6132:
6130:
6129:
6120:
6119:
6114:
6112:Interleukin 37
6109:
6107:Interleukin 18
6104:
6095:
6093:
6087:
6086:
6084:
6083:
6078:
6073:
6068:
6063:
6058:
6049:
6048:
6021:Interleukin 17
6014:
6012:
6006:
6005:
6003:
6002:
6000:Interleukin 15
5997:
5988:
5986:
5980:
5979:
5977:
5976:
5971:
5966:
5957:
5956:
5954:Interleukin 13
5951:
5946:
5941:
5932:
5930:
5924:
5923:
5921:
5920:
5915:
5906:
5905:
5903:Interleukin 12
5900:
5891:
5889:
5883:
5882:
5880:
5879:
5874:
5865:
5863:
5857:
5856:
5854:
5853:
5848:
5839:
5837:
5831:
5830:
5828:
5827:
5818:
5817:
5808:
5806:
5800:
5799:
5797:
5796:
5788:
5786:
5780:
5779:
5777:
5776:
5767:
5765:
5759:
5758:
5756:
5755:
5750:
5745:
5740:
5735:
5730:
5725:
5720:
5715:
5710:
5701:
5700:
5695:
5686:
5684:
5678:
5677:
5675:
5674:
5665:
5664:
5659:
5654:
5645:
5644:
5635:
5634:
5625:
5623:
5617:
5616:
5614:
5613:
5608:
5599:
5598:
5589:
5588:
5586:Interleukin 13
5583:
5578:
5569:
5567:
5561:
5560:
5558:
5557:
5555:Promegapoietin
5552:
5547:
5542:
5537:
5532:
5523:
5521:
5515:
5514:
5512:
5511:
5506:
5501:
5492:
5491:
5486:
5481:
5479:Pegaldesleukin
5476:
5471:
5466:
5461:
5456:
5447:
5445:
5439:
5438:
5436:
5435:
5426:
5425:
5420:
5415:
5406:
5405:
5400:
5395:
5390:
5381:
5380:
5375:
5370:
5352:
5350:
5344:
5343:
5333:
5332:
5325:
5318:
5310:
5301:
5300:
5298:
5297:
5296:
5295:
5294:
5293:
5288:
5283:
5278:
5273:
5263:
5259:
5258:
5257:
5252:
5242:
5233:
5227:
5226:
5225:
5224:
5219:
5206:
5204:
5198:
5197:
5194:
5193:
5191:
5190:
5185:
5180:
5179:
5178:
5173:
5162:
5160:
5156:
5155:
5152:
5151:
5149:
5148:
5133:
5131:
5125:
5124:
5122:
5121:
5116:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5071:
5061:
5059:
5057:Ig superfamily
5053:
5052:
5049:
5048:
5045:
5044:
5042:
5041:
5035:
5033:
5027:
5026:
5024:
5023:
5018:
5013:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4942:
4940:
4931:
4925:
4924:
4922:
4921:
4920:
4919:
4914:
4904:
4899:
4894:
4889:
4884:
4874:
4872:
4863:
4857:
4856:
4853:
4852:
4850:
4849:
4844:
4839:
4834:
4828:
4826:
4822:
4821:
4819:
4818:
4813:
4808:
4803:
4797:
4795:
4785:
4784:
4782:
4781:
4780:
4779:
4774:
4769:
4764:
4753:
4748:
4743:
4738:
4732:
4730:
4723:
4722:
4720:
4719:
4714:
4709:
4703:
4701:
4695:
4694:
4692:
4691:
4686:
4681:
4676:
4667:
4657:
4655:
4646:
4631:
4625:
4624:
4622:
4621:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4576:
4571:
4566:
4565:
4564:
4559:
4549:
4543:
4541:
4535:
4534:
4531:
4530:
4528:
4527:
4522:
4516:
4514:
4510:
4509:
4507:
4506:
4500:
4498:
4494:
4493:
4491:
4490:
4485:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4430:
4425:
4420:
4415:
4410:
4403:
4401:
4397:
4396:
4394:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4348:
4343:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4276:
4270:
4264:
4258:
4252:
4250:
4243:
4234:
4230:
4229:
4222:Cell signaling
4218:
4217:
4210:
4203:
4195:
4186:
4185:
4183:
4182:
4176:
4169:
4167:
4161:
4154:
4152:
4146:
4139:
4137:
4131:
4124:
4122:
4116:
4109:
4107:
4101:
4094:
4092:
4086:
4079:
4077:
4071:
4064:
4062:
4056:
4049:
4047:
4041:
4034:
4032:
4026:
4019:
4017:
4011:
4004:
4002:
3996:
3989:
3987:
3981:
3974:
3972:
3966:
3959:
3957:
3951:
3944:
3942:
3936:
3929:
3927:
3921:
3914:
3912:
3906:
3899:
3897:
3891:
3884:
3882:
3876:
3869:
3866:
3863:
3862:
3857:
3856:
3849:
3842:
3834:
3815:
3814:
3802:
3801:External links
3799:
3797:
3796:
3759:
3714:
3685:
3642:
3606:(1): 192–207.
3594:
3568:(4): 275–281.
3557:
3528:
3502:(1): 153–159.
3491:
3462:
3434:(2): 233–238.
3419:
3409:(2): 161–172.
3396:
3394:
3391:
3389:
3388:
3359:
3330:(5): 781–795.
3303:
3252:
3223:(1): 110–120.
3203:
3154:
3105:
3054:
3017:(1): 192–207.
3000:
2951:
2894:
2845:
2826:(3): 229–237.
2810:
2791:(8): 711–726.
2774:
2738:
2689:
2658:(2): 331–341.
2638:
2624:
2572:
2537:
2508:(1): 143–155.
2488:
2459:(1): 128–142.
2439:
2380:
2345:
2296:
2241:
2182:
2164:
2146:
2125:
2103:
2101:
2098:
2077:
2074:
2041:
2038:
2013:patients. The
1994:
1980:
1977:
1942:
1939:
1935:lamina propria
1915:
1907:
1899:
1889:
1886:
1860:
1857:
1818:
1815:
1808:
1807:
1793:
1790:
1664:
1661:
1606:
1605:
1602:
1601:
1596:
1586:
1585:
1579:
1578:
1575:
1574:
1572:
1570:
1563:
1562:
1555:
1548:
1544:
1543:
1540:
1539:
1529:
1528:
1522:
1519:
1518:
1508:
1507:
1501:
1497:
1496:
1493:
1492:
1482:
1481:
1475:
1472:
1471:
1461:
1460:
1454:
1450:
1449:
1446:
1445:
1437:
1436:
1430:
1427:
1426:
1418:
1417:
1411:
1405:
1404:
1401:
1400:
1392:
1391:
1385:
1382:
1381:
1373:
1372:
1366:
1360:
1359:
1356:
1355:
1347:
1346:
1340:
1337:
1336:
1328:
1327:
1321:
1315:
1314:
1309:
1304:
1300:
1299:
1289:
1288:
1285:
1284:
1273:
1272:
1270:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
803:
801:
797:
796:
794:
793:
788:
783:
778:
773:
768:
763:
758:
752:
750:
746:
745:
743:
742:
737:
732:
727:
722:
716:
714:
710:
709:
699:
698:
695:
694:
691:
690:
682:
681:
663:
657:
656:
653:
652:
644:
643:
640:
639:
637:
636:
632:
628:
624:
620:
616:
612:
608:
604:
600:
596:
593:
592:
581:
578:
577:
575:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
531:
530:
518:
517:
509:
498:
492:
491:
488:RNA expression
480:
479:
476:
475:
467:
463:
462:
454:
451:
446:
440:
439:
430:
423:
417:
413:
412:
407:
401:
400:
392:
391:
379:
378:
375:
374:
366:
362:
361:
353:
350:
345:
339:
338:
329:
322:
316:
312:
311:
304:
298:
297:
289:
288:
276:
275:
232:
228:
227:
219:
211:
210:
206:
205:
202:
201:
198:
197:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
6608:
6597:
6594:
6592:
6589:
6588:
6586:
6567:
6564:
6562:
6559:
6556:
6555:
6552:
6549:
6546:
6542:
6539:
6537:
6534:
6531:
6527:
6523:
6520:
6517:
6513:
6509:
6506:
6503:
6499:
6496:
6494:
6491:
6490:
6488:
6484:
6477:
6473:
6472:
6470:
6468:
6464:
6461:
6457:
6451:
6448:
6445:
6444:
6441:
6438:
6435:
6431:
6427:
6423:
6420:
6417:
6416:
6414:
6412:
6408:
6402:
6399:
6396:
6395:
6393:
6391:
6387:
6381:
6378:
6375:
6374:
6372:
6370:
6366:
6360:
6357:
6354:
6350:
6346:
6343:
6341:
6338:
6335:
6334:
6332:
6330:
6326:
6320:
6317:
6314:
6313:
6311:
6309:
6305:
6299:
6296:
6294:
6293:Tildrakizumab
6291:
6289:
6286:
6284:
6281:
6279:
6276:
6274:
6271:
6268:
6267:
6264:
6261:
6258:
6257:
6255:
6253:
6249:
6242:
6239:
6236:
6235:
6232:
6229:
6226:
6225:
6223:
6221:
6217:
6211:
6208:
6206:
6203:
6200:
6199:
6196:
6193:
6191:
6188:
6185:
6184:
6182:
6180:
6176:
6169:
6166:
6163:
6162:
6159:
6156:
6154:
6151:
6149:
6146:
6143:
6142:
6140:
6138:
6134:
6128:
6125:
6122:
6121:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6097:
6096:
6094:
6092:
6088:
6082:
6079:
6077:
6074:
6072:
6069:
6067:
6064:
6062:
6059:
6057:
6054:
6051:
6050:
6046:
6042:
6038:
6034:
6030:
6026:
6022:
6019:
6016:
6015:
6013:
6011:
6007:
6001:
5998:
5996:
5993:
5990:
5989:
5987:
5985:
5981:
5975:
5972:
5970:
5967:
5965:
5962:
5959:
5958:
5955:
5952:
5950:
5949:Interleukin 4
5947:
5945:
5942:
5940:
5937:
5934:
5933:
5931:
5929:
5925:
5919:
5916:
5914:
5911:
5908:
5907:
5904:
5901:
5899:
5898:Edodekin alfa
5896:
5893:
5892:
5890:
5888:
5884:
5878:
5875:
5873:
5870:
5867:
5866:
5864:
5862:
5858:
5852:
5849:
5847:
5844:
5841:
5840:
5838:
5836:
5832:
5826:
5823:
5820:
5819:
5816:
5815:Interleukin 9
5813:
5810:
5809:
5807:
5805:
5801:
5794:
5790:
5789:
5787:
5785:
5781:
5775:
5774:Interleukin 7
5772:
5769:
5768:
5766:
5764:
5760:
5754:
5751:
5749:
5746:
5744:
5741:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5719:
5716:
5714:
5711:
5709:
5706:
5703:
5702:
5699:
5698:Interleukin 6
5696:
5694:
5693:Atexakin alfa
5691:
5688:
5687:
5685:
5683:
5679:
5673:
5670:
5667:
5666:
5663:
5660:
5658:
5655:
5653:
5650:
5647:
5646:
5643:
5640:
5637:
5636:
5633:
5632:Interleukin 5
5630:
5627:
5626:
5624:
5622:
5618:
5612:
5609:
5607:
5604:
5601:
5600:
5597:
5594:
5591:
5590:
5587:
5584:
5582:
5581:Interleukin 4
5579:
5577:
5574:
5571:
5570:
5568:
5566:
5562:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5535:Interleukin 3
5533:
5531:
5528:
5525:
5524:
5522:
5520:
5516:
5510:
5507:
5505:
5502:
5500:
5497:
5494:
5493:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5474:Interleukin 2
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5449:
5448:
5446:
5444:
5440:
5434:
5431:
5428:
5427:
5424:
5421:
5419:
5416:
5414:
5411:
5408:
5407:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5383:
5382:
5379:
5376:
5374:
5371:
5368:
5364:
5360:
5359:Interleukin 1
5357:
5354:
5353:
5351:
5349:
5345:
5341:
5338:
5331:
5326:
5324:
5319:
5317:
5312:
5311:
5308:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5268:
5267:
5260:
5256:
5253:
5251:
5248:
5247:
5246:
5239:
5238:
5237:
5234:
5232:
5229:
5228:
5223:
5220:
5218:
5215:
5214:
5213:
5212:
5208:
5207:
5205:
5199:
5189:
5186:
5184:
5181:
5177:
5174:
5172:
5169:
5168:
5167:
5166:Hematopoietic
5164:
5163:
5161:
5157:
5146:
5142:
5138:
5135:
5134:
5132:
5130:
5126:
5120:
5117:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5066:
5063:
5062:
5060:
5058:
5054:
5040:
5037:
5036:
5034:
5032:
5028:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4943:
4941:
4939:
4935:
4932:
4930:
4926:
4918:
4915:
4913:
4910:
4909:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4879:
4876:
4875:
4873:
4871:
4867:
4864:
4862:
4858:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4829:
4827:
4823:
4817:
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4798:
4796:
4794:
4790:
4786:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4759:
4758:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4733:
4731:
4729:
4724:
4718:
4715:
4713:
4710:
4708:
4705:
4704:
4702:
4700:
4696:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4671:
4668:
4666:
4662:
4659:
4658:
4656:
4654:
4650:
4647:
4639:
4635:
4632:
4630:
4626:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4574:TNFSF5/CD40LG
4572:
4570:
4567:
4563:
4560:
4558:
4555:
4554:
4553:
4550:
4548:
4545:
4544:
4542:
4540:
4536:
4526:
4523:
4521:
4518:
4517:
4515:
4511:
4505:
4502:
4501:
4499:
4495:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4471:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4408:
4405:
4404:
4402:
4398:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4347:
4344:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4280:
4277:
4274:
4271:
4268:
4265:
4262:
4259:
4257:
4254:
4253:
4251:
4247:
4244:
4242:
4238:
4235:
4231:
4227:
4223:
4216:
4211:
4209:
4204:
4202:
4197:
4196:
4193:
4179:
4173:
4168:
4164:
4158:
4153:
4149:
4143:
4138:
4134:
4128:
4123:
4119:
4113:
4108:
4104:
4098:
4093:
4089:
4083:
4078:
4074:
4068:
4063:
4059:
4053:
4048:
4044:
4038:
4033:
4029:
4023:
4018:
4014:
4008:
4003:
3999:
3993:
3988:
3984:
3978:
3973:
3969:
3963:
3958:
3954:
3948:
3943:
3939:
3933:
3928:
3924:
3918:
3913:
3909:
3903:
3898:
3894:
3888:
3883:
3879:
3873:
3868:
3867:
3864:
3855:
3850:
3848:
3843:
3841:
3836:
3835:
3832:
3828:
3827:
3825:
3824:public domain
3821:
3812:
3808:
3805:
3804:
3793:
3789:
3785:
3781:
3777:
3773:
3769:
3765:
3760:
3756:
3752:
3747:
3742:
3737:
3732:
3728:
3724:
3720:
3715:
3711:
3707:
3703:
3699:
3695:
3691:
3686:
3682:
3678:
3674:
3670:
3665:
3660:
3656:
3652:
3648:
3643:
3639:
3635:
3631:
3627:
3622:
3617:
3613:
3609:
3605:
3601:
3595:
3591:
3587:
3583:
3579:
3575:
3571:
3567:
3563:
3558:
3554:
3550:
3546:
3542:
3538:
3534:
3529:
3525:
3521:
3517:
3513:
3509:
3505:
3501:
3497:
3496:Human Biology
3492:
3488:
3484:
3480:
3476:
3472:
3468:
3463:
3459:
3455:
3450:
3445:
3441:
3437:
3433:
3429:
3425:
3420:
3416:
3412:
3408:
3404:
3398:
3397:
3376:
3369:
3363:
3355:
3351:
3346:
3341:
3337:
3333:
3329:
3325:
3321:
3314:
3312:
3310:
3308:
3299:
3295:
3290:
3285:
3280:
3275:
3271:
3267:
3263:
3256:
3248:
3244:
3239:
3234:
3230:
3226:
3222:
3218:
3214:
3207:
3199:
3195:
3190:
3185:
3181:
3177:
3173:
3169:
3165:
3158:
3150:
3146:
3141:
3136:
3132:
3128:
3124:
3120:
3116:
3109:
3101:
3097:
3092:
3087:
3082:
3077:
3073:
3069:
3065:
3058:
3050:
3046:
3042:
3038:
3033:
3028:
3024:
3020:
3016:
3012:
3004:
2996:
2992:
2987:
2982:
2978:
2974:
2970:
2966:
2962:
2955:
2947:
2943:
2938:
2933:
2929:
2925:
2921:
2917:
2913:
2909:
2905:
2898:
2890:
2886:
2881:
2876:
2872:
2868:
2864:
2860:
2856:
2849:
2841:
2837:
2833:
2829:
2825:
2821:
2814:
2806:
2802:
2798:
2794:
2790:
2786:
2778:
2770:
2766:
2762:
2758:
2754:
2750:
2742:
2734:
2730:
2725:
2720:
2716:
2712:
2708:
2704:
2703:Redox Biology
2700:
2693:
2685:
2681:
2676:
2671:
2666:
2661:
2657:
2653:
2649:
2642:
2634:
2628:
2620:
2616:
2612:
2608:
2604:
2600:
2596:
2592:
2585:
2583:
2581:
2579:
2577:
2568:
2564:
2560:
2556:
2552:
2548:
2541:
2533:
2529:
2524:
2519:
2515:
2511:
2507:
2503:
2499:
2492:
2484:
2480:
2475:
2470:
2466:
2462:
2458:
2454:
2450:
2443:
2435:
2431:
2426:
2421:
2416:
2411:
2407:
2403:
2399:
2395:
2391:
2384:
2376:
2372:
2368:
2364:
2361:(1): 95–101.
2360:
2356:
2349:
2341:
2337:
2332:
2327:
2323:
2319:
2315:
2311:
2307:
2300:
2292:
2288:
2284:
2280:
2276:
2272:
2268:
2264:
2260:
2256:
2248:
2246:
2237:
2233:
2228:
2223:
2218:
2213:
2209:
2205:
2201:
2197:
2193:
2186:
2178:
2174:
2168:
2160:
2156:
2150:
2143:
2139:
2134:
2132:
2130:
2122:
2118:
2113:
2111:
2109:
2104:
2097:
2095:
2091:
2087:
2083:
2073:
2071:
2067:
2063:
2061:
2057:
2053:
2051:
2046:
2037:
2035:
2030:
2028:
2024:
2020:
2016:
2012:
2008:
2003:
2001:
1997:
1990:
1986:
1976:
1974:
1969:
1965:
1960:
1956:
1952:
1948:
1938:
1936:
1932:
1927:
1925:
1921:
1913:
1912:kill the cell
1904:
1902:
1895:
1885:
1883:
1879:
1875:
1870:
1867:
1856:
1854:
1850:
1846:
1841:
1839:
1838:osteomyelitis
1835:
1830:
1828:
1824:
1814:
1811:
1803:
1802:
1801:
1799:
1789:
1787:
1783:
1779:
1775:
1771:
1767:
1763:
1759:
1754:
1752:
1748:
1744:
1740:
1736:
1731:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1685:
1680:
1678:
1674:
1670:
1660:
1658:
1654:
1650:
1649:interleukin-1
1646:
1643:
1639:
1636:
1632:
1628:
1624:
1620:
1616:
1612:
1600:
1595:
1591:
1587:
1584:
1580:
1573:
1571:
1568:
1564:
1560:
1556:
1553:
1549:
1545:
1538:
1536:
1530:
1526:
1523:
1517:
1515:
1509:
1505:
1502:
1498:
1491:
1489:
1483:
1479:
1476:
1470:
1468:
1462:
1458:
1455:
1453:RefSeq (mRNA)
1451:
1444:
1443:
1438:
1434:
1431:
1425:
1424:
1419:
1415:
1412:
1410:
1406:
1399:
1398:
1393:
1389:
1386:
1380:
1379:
1374:
1370:
1367:
1365:
1361:
1354:
1353:
1348:
1344:
1341:
1335:
1334:
1329:
1325:
1322:
1320:
1316:
1313:
1310:
1308:
1305:
1301:
1298:
1294:
1290:
1283:
1279:
1274:
1268:
1265:
1263:
1260:
1258:
1255:
1253:
1250:
1248:
1245:
1243:
1240:
1238:
1235:
1233:
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1195:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1138:
1135:
1133:
1130:
1128:
1125:
1123:
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1103:
1100:
1098:
1095:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
804:
802:
799:
798:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
753:
751:
748:
747:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
717:
715:
712:
711:
708:
707:Gene ontology
704:
700:
688:
683:
679:
672:
667:
664:
662:
658:
650:
645:
634:
630:
626:
622:
618:
614:
610:
606:
602:
598:
597:
594:
590:
585:
582:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
535:
532:
528:
523:
520:
519:
516:
514:
510:
508:
507:
503:
502:
499:
497:
493:
489:
485:
481:
473:
468:
464:
460:
455:
445:
441:
434:
427:
421:
414:
406:
402:
398:
393:
389:
384:
380:
372:
367:
363:
359:
354:
344:
340:
333:
326:
320:
313:
309:
303:
299:
295:
290:
286:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
229:
224:
217:
212:
207:
196:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
6596:Interleukins
6557:
6545:M-CSFR/CSF1R
6532:heterodimer)
6518:heterodimer)
6447:Antagonists:
6446:
6418:
6397:
6376:
6336:
6315:
6288:Risankizumab
6269:
6259:
6237:
6227:
6210:NNC0114-0006
6205:NNC0114-0005
6201:
6186:
6164:
6144:
6123:
6098:
6052:
6017:
5991:
5974:Tralokinumab
5969:Lebrikizumab
5964:Anrukinzumab
5960:
5935:
5909:
5894:
5868:
5842:
5821:
5811:
5770:
5713:Clazakizumab
5704:
5689:
5668:
5652:Benralizumab
5648:
5639:Antagonists:
5638:
5628:
5611:Pascolizumab
5602:
5593:Antagonists:
5592:
5572:
5526:
5495:
5450:
5429:
5409:
5385:Antagonists:
5384:
5366:
5355:
5261:
5240:
5209:
5201:By function/
5073:
4912:IL28/IFNL2+3
4177:
4162:
4147:
4132:
4117:
4102:
4087:
4072:
4057:
4042:
4027:
4012:
3997:
3982:
3967:
3952:
3937:
3922:
3907:
3892:
3877:
3817:
3816:
3767:
3763:
3726:
3722:
3693:
3689:
3664:10.2741/1845
3654:
3650:
3621:2318/1711962
3603:
3599:
3565:
3561:
3539:(1): 87–94.
3536:
3532:
3499:
3495:
3470:
3466:
3431:
3427:
3406:
3402:
3379:. Retrieved
3374:
3362:
3327:
3323:
3269:
3265:
3255:
3220:
3216:
3206:
3171:
3167:
3157:
3122:
3118:
3108:
3071:
3067:
3057:
3032:2318/1711962
3014:
3010:
3003:
2968:
2964:
2954:
2911:
2907:
2897:
2862:
2858:
2848:
2823:
2819:
2813:
2788:
2784:
2777:
2755:(2): 67–72.
2752:
2748:
2741:
2706:
2702:
2692:
2655:
2651:
2641:
2627:
2597:(1): e2400.
2594:
2590:
2550:
2546:
2540:
2505:
2501:
2491:
2456:
2452:
2442:
2397:
2393:
2383:
2358:
2354:
2348:
2313:
2309:
2299:
2258:
2254:
2199:
2195:
2185:
2176:
2167:
2158:
2149:
2079:
2064:
2054:
2043:
2033:
2031:
2004:
1982:
1944:
1928:
1905:
1891:
1871:
1862:
1842:
1831:
1820:
1812:
1809:
1795:
1766:pyrin domain
1758:inflammasome
1755:
1732:
1728:chromosome 2
1681:
1666:
1641:
1630:
1626:
1622:
1618:
1614:
1610:
1609:
1532:
1511:
1485:
1464:
1440:
1421:
1395:
1376:
1350:
1331:
1311:
1306:
1062:MAPK cascade
511:
504:
470:129,213,059
457:129,206,490
369:112,836,816
356:112,829,751
231:External IDs
74:
18:
6298:Ustekinumab
6278:Briakinumab
6270:Antibodies:
6241:Fezakinumab
6238:Antibodies:
6202:Antibodies:
6190:Denenicokin
6165:Antibodies:
6102:Iboctadekin
6081:Vunakizumab
6076:Secukinumab
6066:Perakizumab
6053:Antibodies:
5961:Antibodies:
5918:Ustekinumab
5913:Briakinumab
5910:Antibodies:
5822:Antibodies:
5748:Tocilizumab
5718:Elsilimomab
5705:Antibodies:
5657:Mepolizumab
5649:Antibodies:
5603:Antibodies:
5530:Daniplestim
5499:Basiliximab
5496:Antibodies:
5464:Celmoleukin
5459:Aldesleukin
5423:Lutikizumab
5418:Gevokizumab
5413:Canakinumab
5410:Antibodies:
5129:IL17 family
4870:IL10 family
4789:IL12 family
4641:(grouped by
4629:Interleukin
4552:Lymphotoxin
3860:PDB gallery
3657:: 889–898.
2865:: 621–668.
2709:: 296–307.
2094:transcoding
2056:Canakinumab
1959:canakinumab
1853:natalizumab
1832:Intestinal
1692:macrophages
619:bone marrow
599:granulocyte
565:gallbladder
541:granulocyte
209:Identifiers
6585:Categories
6353:B (IFN-λ3)
6349:A (IFN-λ2)
6283:Guselkumab
6273:Brazikumab
6168:Fletikumab
6071:Remtolumab
6061:Ixekizumab
6056:Brodalumab
5939:Binetrakin
5877:Oprelvekin
5846:Ilodecakin
5825:Enokizumab
5738:Siltuximab
5728:Olokizumab
5662:Reslizumab
5596:Pitrakinra
5576:Binetrakin
5545:Milodistim
5540:Leridistim
5509:Inolimomab
5484:Teceleukin
5403:Isunakinra
5340:modulators
5236:Lymphokine
5074:IL1B/IL1F2
5069:IL1A/IL1F1
5065:IL1 family
4929:Interferon
4917:IL29/IFNL1
3074:(1): 158.
2675:2262/67623
2144:, May 2017
2123:, May 2017
2100:References
2066:Rilonacept
1920:pyroptosis
1906:Firstly, T
1880:inhibitor
1792:Properties
1756:Different
1751:γδ T cells
1653:IL-1 alpha
627:right lung
515:(ortholog)
252:HomoloGene
6558:Unsorted:
6419:Agonists:
6398:Agonists:
6377:Agonists:
6337:Agonists:
6316:Agonists:
6260:Agonists:
6228:Agonists:
6187:Agonists:
6145:Agonists:
6117:Tadekinig
6099:Agonists:
6018:Agonists:
5992:Agonists:
5936:Agonists:
5895:Agonists:
5869:Agonists:
5843:Agonists:
5812:Agonists:
5771:Agonists:
5753:Levilimab
5743:Sirukumab
5733:Sarilumab
5690:Agonists:
5629:Agonists:
5606:Dupilumab
5573:Agonists:
5550:Muplestim
5527:Agonists:
5451:Agonists:
5378:Pifonakin
5373:Mobenakin
5356:Agonists:
5114:33/IL1F11
5079:1Ra/IL1F3
4726:IL6 like/
4443:CXCL8/IL8
4241:Chemokine
4233:By family
4226:cytokines
3638:160014053
3381:5 October
3174:: 29–39.
3049:160014053
2619:252762935
2082:homoglyph
2070:Regeneron
2027:microglia
2011:Alzheimer
1964:caspase-1
1962:activate
1834:dysbiosis
1712:apoptosis
1704:caspase 1
1696:monocytes
1688:cytokines
1657:caspase 1
1535:NP_032387
1514:NP_000567
1488:NM_008361
1467:NM_000576
1297:Orthologs
756:cytoplasm
260:GeneCards
6512:IL-22Rα1
6478:instead.
5795:instead.
5723:mAb 1339
5708:ARGX-109
5672:TPI ASM8
5642:YM-90709
5393:Anakinra
5388:AF-12198
5231:Monokine
4760:+non IL
4645:subunit)
4643:receptor
4614:TNFSF13B
4562:TNFC/LTB
4557:TNFB/LTA
3784:17035400
3755:17006981
3710:16375755
3681:23009646
3673:16146780
3630:31107974
3590:72570361
3582:15925866
3553:15638726
3516:15222686
3487:12220547
3458:12149413
3415:12101072
3354:28534174
3298:31379825
3272:: 1618.
3247:23221073
3198:29454857
3149:29760166
3100:30447690
3041:31107974
2995:28583987
2946:25274309
2889:19302049
2840:14642889
2805:11759041
2769:11683587
2749:Cytokine
2733:25625584
2684:19682929
2652:Immunity
2611:36209388
2140:–
2119:–
2045:Anakinra
2034:in vitro
2032:Lastly,
1663:Function
1651:(IL-1):
1635:cytokine
1583:Wikidata
1276:Sources:
771:lysosome
569:appendix
545:monocyte
6530:IL-10Rβ
6526:IL-20Rα
6516:IL-20Rβ
6450:IL-36RA
5995:ALT-803
5119:18/IL1G
4861:Type II
4793:IL12RB1
4699:β chain
4653:γ chain
4609:TNFSF13
4604:TNFSF11
4599:TNFSF10
4281:/RANTES
3792:8542733
3746:4088226
3524:2816300
3449:3835694
3345:5699978
3289:6646526
3238:3544415
3189:5924621
3140:5987176
3091:6240225
2986:5509030
2937:4268032
2916:Bibcode
2880:2996236
2724:4315937
2567:4549027
2532:5033418
2523:2139186
2483:5033417
2474:2139184
2402:Bibcode
2375:2954882
2340:3490654
2291:4240002
2283:2989698
2263:Bibcode
2236:6083565
2204:Bibcode
2142:Ensembl
2121:Ensembl
2086:sharp s
1782:obesity
1673:mitogen
1669:pyrogen
1638:protein
1409:UniProt
1364:Ensembl
1303:Species
1282:QuickGO
786:vesicle
761:cytosol
573:decidua
490:pattern
216:Aliases
6486:Others
6459:Others
6411:IL1RL2
6390:IL1RL1
6127:IL18BP
5398:IL-1RA
5109:IL1F10
5006:IFNA21
5001:IFNA17
4996:IFNA16
4991:IFNA14
4986:IFNA13
4981:IFNA10
4638:Type I
4594:TNFSF9
4589:TNFSF8
4584:TNFSF7
4579:TNFSF6
4569:TNFSF4
4504:CX3CL1
4488:CXCL17
4483:CXCL16
4478:CXCL15
4473:CXCL14
4468:CXCL13
4463:CXCL12
4458:CXCL11
4453:CXCL10
4275:/MIP1β
4269:/MIP1α
3813:(MeSH)
3790:
3782:
3753:
3743:
3708:
3679:
3671:
3636:
3628:
3588:
3580:
3551:
3522:
3514:
3485:
3456:
3446:
3413:
3352:
3342:
3296:
3286:
3245:
3235:
3196:
3186:
3147:
3137:
3098:
3088:
3047:
3039:
2993:
2983:
2944:
2934:
2908:Nature
2887:
2877:
2838:
2803:
2767:
2731:
2721:
2682:
2617:
2609:
2565:
2530:
2520:
2481:
2471:
2432:
2425:431999
2422:
2373:
2338:
2331:311823
2328:
2289:
2281:
2255:Nature
2234:
2227:392262
2224:
2000:GM-CSF
1569:search
1567:PubMed
1442:P10749
1423:P01584
1319:Entrez
661:BioGPS
615:embryo
611:spleen
348:2q14.1
240:147720
6369:IL-31
6329:IL-28
6308:IL-27
6252:IL-23
6220:IL-22
6179:IL-21
6137:IL-20
6091:IL-18
6010:IL-17
5984:IL-15
5928:IL-13
5887:IL-12
5861:IL-11
5835:IL-10
5171:KITLG
5159:Other
5145:IL17A
5104:IL1F9
5099:IL1F8
5094:IL1F7
5089:IL1F6
5084:IL1F5
5021:IFNW1
5011:IFNB1
4976:IFNA8
4971:IFNA7
4966:IFNA6
4961:IFNA5
4956:IFNA4
4951:IFNA2
4946:IFNA1
4825:Other
4728:gp130
4717:GMCSF
4497:CX3CL
4448:CXCL9
4438:CXCL7
4433:CXCL6
4428:CXCL5
4423:CXCL4
4418:CXCL3
4413:CXCL2
4407:CXCL1
4391:CCL28
4386:CCL27
4381:CCL26
4376:CCL25
4371:CCL24
4366:CCL23
4361:CCL22
4356:CCL21
4351:CCL20
4346:CCL19
4340:CCL18
4335:CCL17
4330:CCL16
4325:CCL15
4320:CCL14
4315:CCL13
4310:CCL12
4305:CCL11
4263:/MCP1
3788:S2CID
3677:S2CID
3634:S2CID
3586:S2CID
3520:S2CID
3371:(PDF)
3045:S2CID
2615:S2CID
2434:22079
2287:S2CID
1878:RANKL
1762:NLRP3
1747:IL-22
1743:IL-21
1739:IL-17
1735:IL-23
1615:IL-1β
1352:16176
1312:Mouse
1307:Human
1278:Amigo
603:blood
549:blood
513:Mouse
506:Human
453:Start
388:Mouse
352:Start
285:Human
248:96543
6476:here
6474:See
5804:IL-9
5793:here
5784:IL-8
5763:IL-7
5682:IL-6
5621:IL-5
5565:IL-4
5519:IL-3
5443:IL-2
5348:IL-1
5291:IL13
5286:IL10
5255:TNFβ
5250:IFNγ
5222:TNFA
5203:cell
5183:SPP1
5141:IL25
5137:IL17
5039:IFNG
5016:IFNK
4902:IL26
4897:IL24
4892:IL20
4887:IL19
4882:IL22
4878:IL10
4847:IL34
4842:IL32
4837:IL16
4832:IL14
4816:IL35
4811:IL27
4806:IL23
4801:IL12
4777:CTF1
4772:CNTF
4756:IL31
4751:IL30
4746:IL27
4741:IL11
4689:IL21
4674:IL13
4665:IL15
4547:TNFA
4525:XCL2
4520:XCL1
4400:CXCL
4300:CCL9
4295:CCL8
4290:CCL7
4285:CCL6
4279:CCL5
4273:CCL4
4267:CCL3
4261:CCL2
4256:CCL1
4178:9ilb
4163:7i1b
4148:6i1b
4133:5i1b
4118:4i1b
4103:41bi
4088:31bi
4073:2nvh
4058:2i1b
4043:21bi
4028:1twm
4013:1twe
3998:1tp0
3983:1too
3968:1t4q
3953:1s0l
3938:1l2h
3923:1itb
3908:1iob
3893:1i1b
3878:1hib
3780:PMID
3751:PMID
3706:PMID
3669:PMID
3626:PMID
3578:PMID
3549:PMID
3512:PMID
3483:PMID
3454:PMID
3411:PMID
3383:2020
3350:PMID
3294:PMID
3243:PMID
3194:PMID
3145:PMID
3096:PMID
3037:PMID
2991:PMID
2942:PMID
2885:PMID
2836:PMID
2801:PMID
2765:PMID
2729:PMID
2680:PMID
2607:PMID
2563:PMID
2528:PMID
2479:PMID
2430:PMID
2371:PMID
2355:Gene
2336:PMID
2279:PMID
2232:PMID
2090:beta
1953:and
1931:GALT
1892:The
1874:RANK
1784:and
1745:and
1724:pain
1645:gene
1642:IL1B
1333:3553
496:Bgee
444:Band
405:Chr.
343:Band
302:Chr.
264:IL1B
236:OMIM
223:IL1B
193:5BVP
189:4GAF
185:9ILB
181:7I1B
177:6I1B
173:5I1B
169:4I1B
165:4GAI
161:4G6M
157:4G6J
153:4DEP
149:41BI
145:3POK
141:3O4O
137:31BI
133:2NVH
129:2KH2
125:2I1B
121:21BI
117:1TWM
113:1TWE
109:1TP0
105:1TOO
101:1T4Q
97:1S0L
93:1L2H
89:1ITB
85:1IOB
81:1I1B
77:1HIB
58:RCSB
55:PDBe
24:IL1B
6502:CD4
6467:JAK
5281:IL6
5276:IL5
5271:IL4
5217:IL1
5188:MIF
4767:LIF
4762:OSM
4736:IL6
4712:IL5
4707:IL3
4684:IL9
4679:IL7
4670:IL4
4661:IL2
4619:EDA
4539:TNF
4513:XCL
4409:/KC
4249:CCL
3772:doi
3741:PMC
3731:doi
3698:doi
3659:doi
3616:hdl
3608:doi
3604:146
3570:doi
3541:doi
3504:doi
3475:doi
3444:PMC
3436:doi
3340:PMC
3332:doi
3328:125
3284:PMC
3274:doi
3233:PMC
3225:doi
3184:PMC
3176:doi
3172:170
3135:PMC
3127:doi
3086:PMC
3076:doi
3027:hdl
3019:doi
3015:146
2981:PMC
2973:doi
2969:198
2932:PMC
2924:doi
2912:516
2875:PMC
2867:doi
2828:doi
2793:doi
2757:doi
2719:PMC
2711:doi
2670:hdl
2660:doi
2599:doi
2555:doi
2518:PMC
2510:doi
2506:136
2469:PMC
2461:doi
2457:136
2420:PMC
2410:doi
2363:doi
2326:PMC
2318:doi
2271:doi
2259:315
2222:PMC
2212:doi
1995:H17
1851:or
1798:kDa
1749:by
1686:of
466:End
365:End
268:OMA
256:481
244:MGI
48:PDB
6587::
6432:,
6428:,
6351:,
6043:,
6039:,
6035:,
6031:,
6027:,
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2161:.
1993:T
1916:H
1908:H
1900:H
1898:T
1876:/
1613:(
390:)
287:)
270::
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