1761:
1539:. In cells, the priming is accomplished by a protein talin, which binds to the β tail of the integrin dimer and changes its conformation. The α and β integrin chains are both class-I transmembrane proteins: they pass the plasma membrane as single transmembrane alpha-helices. Unfortunately, the helices are too long, and recent studies suggest that, for integrin gpIIbIIIa, they are tilted with respect both to one another and to the plane of the membrane. Talin binding alters the angle of tilt of the β3 chain transmembrane helix in model systems and this may reflect a stage in the process of inside-out signalling which primes integrins. Moreover, talin proteins are able to dimerize and thus are thought to intervene in the clustering of integrin dimers which leads to the formation of a
1721:
recent studies indicate that integrins have additional, multi-faceted roles in cell signaling. Integrins can regulate the receptor tyrosine kinase signaling by recruiting specific adaptors to the plasma membrane. For example, β1c integrin recruits Gab1/Shp2 and presents Shp2 to IGF1R, resulting in dephosphorylation of the receptor. In a reverse direction, when a receptor tyrosine kinase is activated, integrins co-localise at focal adhesion with the receptor tyrosine kinases and their associated signaling molecules.
1517:
difficult to address with available technologies. The default assumption is that they emerge rather like little lollipops, but there is little evidence for this. The integrin structure has drawn attention to this problem, which may have general implications for how membrane proteins work. It appears that the integrin transmembrane helices are tilted (see "Activation" below), which hints that the extracellular chains may also not be orthogonal with respect to the membrane surface.
1688:
membrane. So the focal adhesions contain integrin ligand, integrin molecule, and associate plaque proteins. Binding is propelled by changes in free energy. As previously stated, these complexes connect the extracellular matrix to actin bundles. Cryo-electron tomography reveals that the adhesion contains particles on the cell membrane with diameter of 25 +/- 5 nm and spaced at approximately 45 nm. Treatment with Rho-kinase inhibitor
385:
1592:(thrombocytes) responsible for attachment to fibrin within a developing blood clot. This molecule dramatically increases its binding affinity for fibrin/fibrinogen through association of platelets with exposed collagens in the wound site. Upon association of platelets with collagen, GPIIb/IIIa changes shape, allowing it to bind to fibrin and other blood components to form the clot matrix and stop blood loss.
3824:
646:
232:
42:
2314:
inactive state, and can be rapidly primed, or put into a state capable of binding their ligands, by cytokines. Integrins can assume several different well-defined shapes or "conformational states". Once primed, the conformational state changes to stimulate ligand binding, which then activates the receptors — also by inducing a shape change — to trigger outside-in signal transduction.
1684:. These adhesion complexes attach to the actin cytoskeleton. The integrins thus serve to link two networks across the plasma membrane: the extracellular ECM and the intracellular actin filamentous system. Integrin α6β4 is an exception: it links to the keratin intermediate filament system in epithelial cells.
1559:
Integrins have two main functions, attachment of the cells to the ECM and signal transduction from the ECM to the cells. They are also involved in a wide range of other biological activities, including extravasation, cell-to-cell adhesion, cell migration, and as receptors for certain viruses, such as
1503:
crystal structure obtained for the complete extracellular region of one integrin, αvβ3, shows the molecule to be folded into an inverted V-shape that potentially brings the ligand-binding sites close to the cell membrane. Perhaps more importantly, the crystal structure was also obtained for the same
1469:
of divalent cations, and carries either a calcium or magnesium ion, the principal divalent cations in blood at median concentrations of 1.4 mM (calcium) and 0.8 mM (magnesium). The other two sites become occupied by cations when ligands bind—at least for those ligands involving an acidic
1720:
Integrins play an important role in cell signaling by modulating the cell signaling pathways of transmembrane protein kinases such as receptor tyrosine kinases (RTK). While the interaction between integrin and receptor tyrosine kinases originally was thought of as uni-directional and supportive,
1580:
and other viruses. Recently, the importance of integrins in the progress of autoimmune disorders is also gaining attention of the scientists. These mechanoreceptors seem to regulate autoimmunity by dictating various intracellular pathways to control immune cell adhesion to endothelial cell layers
1534:
When released into the cell membrane, newly synthesized integrin dimers are speculated to be found in the same "bent" conformation revealed by the structural studies described above. One school of thought claims that this bent form prevents them from interacting with their ligands, although bent
1712:, where they are added back to the surface. In this way they are cycled for reuse, enabling the cell to make fresh attachments at its leading front. The cycle of integrin endocytosis and recycling back to the cell surface is important also for not migrating cells and during animal development.
2313:
Beta-1 integrins interact with many alpha integrin chains. Gene knockouts of integrins in mice are not always lethal, which suggests that during embryonal development, one integrin may substitute its function for another in order to allow survival. Some integrins are on the cell surface in an
1724:
The repertoire of integrins expressed on a particular cell can specify the signaling pathway due to the differential binding affinity of ECM ligands for the integrins. The tissue stiffness and matrix composition can initiate specific signaling pathways regulating cell behavior. Clustering and
1687:
Focal adhesions are large molecular complexes, which are generated following interaction of integrins with ECM, then their clustering. The clusters likely provide sufficient intracellular binding sites to permit the formation of stable signaling complexes on the cytoplasmic side of the cell
1520:
Although the crystal structure changed surprisingly little after binding to cilengitide, the current hypothesis is that integrin function involves changes in shape to move the ligand-binding site into a more accessible position, away from the cell surface, and this shape change also triggers
1516:
from the membrane, the ligand binding site would apparently be obstructed, especially as integrin ligands are typically massive and well cross-linked components of the ECM. In fact, little is known about the angle that membrane proteins subtend to the plane of the membrane; this is a problem
1391:
and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino acids, one of the largest of any membrane protein. Outside the cell membrane, the α and β chains lie close together along a length of about
1525:
that only recognize integrins when they have bound to their ligands, or are activated. As the "footprint" that an antibody makes on its binding target is roughly a circle about 3 nm in diameter, the resolution of this technique is low. Nevertheless, these so-called LIBS
3282:
Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, Languino LR (August 2005). "beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts".
1648:, and many others, they enforce a cellular decision on what biological action to take, be it attachment, movement, death, or differentiation. Thus integrins lie at the heart of many cellular biological processes. The attachment of the cell takes place through formation of
1508:. As detailed above, this finally revealed why divalent cations (in the A-domains) are critical for RGD-ligand binding to integrins. The interaction of such sequences with integrins is believed to be a primary switch by which ECM exerts its effects on cell behaviour.
1639:
Cell attachment to the ECM is a basic requirement to build a multicellular organism. Integrins are not simply hooks, but give the cell critical signals about the nature of its surroundings. Together with signals arising from receptors for soluble growth factors like
1511:
The structure poses many questions, especially regarding ligand binding and signal transduction. The ligand binding site is directed towards the C-terminal of the integrin, the region where the molecule emerges from the cell membrane. If it emerges
1756:
Knowledge of the relationship between integrins and receptor tyrosine kinase has laid a foundation for new approaches to cancer therapy. Specifically, targeting integrins associated with RTKs is an emerging approach for inhibiting angiogenesis.
1535:
forms can predominate in high-resolution EM structures of integrin bound to an ECM ligand. Therefore, at least in biochemical experiments, integrin dimers must apparently not be 'unbent' in order to prime them and allow their binding to the
1789:(CNS). There are two obstacles that prevent integrin-mediated regeneration in the CNS: 1) integrins are not localised in the axon of most adult CNS neurons and 2) integrins become inactivated by molecules in the scar tissue after injury.
1703:
through their integrins. During movement, the cell makes new attachments to the substrate at its front and concurrently releases those at its rear. When released from the substrate, integrin molecules are taken back into the cell by
1457:
adhesion molecules (integrins of the β2 family). This α-I domain is the binding site for ligands of such integrins. Those integrins that don't carry this inserted domain also have an A-domain in their ligand binding site, but
3129:
Patla I, Volberg T, Elad N, Hirschfeld-Warneken V, Grashoff C, Fässler R, Spatz JP, Geiger B, Medalia O (September 2010). "Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography".
1482:
Despite many years of effort, discovering the high-resolution structure of integrins proved to be challenging, as membrane proteins are classically difficult to purify, and as integrins are large, complex and highly
1495:
and light scattering, were combined with fragmentary high-resolution crystallographic or NMR data from single or paired domains of single integrin chains, and molecular models postulated for the rest of the chains.
1526:(Ligand-Induced-Binding-Sites) antibodies unequivocally show that dramatic changes in integrin shape routinely occur. However, how the changes detected with antibodies look on the structure is still unknown.
1632:. The connection between the cell and the ECM may help the cell to endure pulling forces without being ripped out of the ECM. The ability of a cell to create this kind of bond is also of vital importance in
1384:; for example, four variants of the beta-1 subunit exist. Through different combinations of the α and β subunits, 24 unique mammalian integrins are generated, excluding splice- and glycosylation variants.
1760:
7066:
3781:"Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis"
895:
nematodes two α subunits and one β subunit. The α and β subunits are both class I transmembrane proteins, so each penetrates the plasma membrane once, and can possess several
1521:
intracellular signaling. There is a wide body of cell-biological and biochemical literature that supports this view. Perhaps the most convincing evidence involves the use of
7086:
3542:"Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation"
1470:
amino acid in their interaction sites. An acidic amino acid features in the integrin-interaction site of many ECM proteins, for example as part of the amino acid sequence
7076:
4855:
3684:
Kazanecki, CC; Uzwiak, DJ; Denhxxardt, DT (1 November 2007). "Control of osteopontin signaling and function by post-translational phosphorylation and protein folding".
883:
of these subunits, which gives rise to an array of unique integrins with varied activity. In mammals, integrins are assembled from eighteen α and eight β subunits, in
5231:
745:
505:
343:
190:
3318:
Kim SH, Turnbull J, Guimond S (May 2011). "Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor".
1725:
activation of the integrins/actin complexes strengthen the focal adhesion interaction and initiate the framework for cell signaling through assembly of adhesomes.
1785:
of damaged PNS neurons and attach to ligands in the ECM to promote axon regeneration. It is unclear whether integrins can promote axon regeneration in the adult
7061:
4234:
4208:
4203:
4198:
4123:
4113:
4054:
1581:
followed by their trans-migration. This process might or might not be dependent on the sheer force faced by the extracellular parts of different integrins.
5596:
3732:"The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23"
3730:
Hermann P, Armant M, Brown E, Rubio M, Ishihara H, Ulrich D, Caspary RG, Lindberg FP, Armitage R, Maliszewski C, Delespesse G, Sarfati M (February 1999).
4304:
3177:. Theoretical and Computational Biophysics Group, Beckman Institute for Advanced Science and Technology: University of Illinois at Urbana-Champaign.
6831:
4906:
2255:
2123:
2005:
1980:
802:, and movement of new receptors to the cell membrane. The presence of integrins allows rapid and flexible responses to events at the cell surface (
6770:
2419:
Sauer FG, Fütterer K, Pinkner JS, Dodson KW, Hultgren SJ, Waksman G (August 1999). "Structural basis of chaperone function and pilus biogenesis".
1441:
Integrins can be categorized in multiple ways. For example, some α chains have an additional structural element (or "domain") inserted toward the
5947:
5139:
4848:
7730:
5872:
817:
Several types of integrins exist, and one cell generally has multiple different types on its surface. Integrins are found in all animals while
134:
122:
1408:
claws, although they don't actually "pinch" their ligand, they chemically interact with it at the insides of the "tips" of their "pinchers".
7799:
7454:
7367:
7312:
7266:
7211:
6946:
6886:
5887:
5817:
5376:
4974:
4916:
1612:) inside the cell. Which ligand in the ECM the integrin can bind to is defined by which α and β subunits the integrin is made of. Among the
7449:
7327:
7226:
7012:
6901:
6701:
6661:
6409:
6328:
6190:
6131:
6093:
6038:
6033:
6023:
5897:
5892:
5862:
5837:
5832:
5822:
5708:
5627:
5566:
5494:
5473:
5458:
5411:
5064:
7549:
7407:
7386:
7342:
7322:
7241:
7221:
6936:
6916:
6896:
6539:
6534:
5867:
5591:
5124:
4921:
4272:
2882:"Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects"
7372:
7362:
7317:
7271:
7261:
7216:
7040:
7007:
6987:
6951:
6941:
6891:
6851:
6323:
6303:
6270:
6151:
6053:
5902:
4841:
2845:
Goldmann WH, Bremer A, Häner M, Aebi U, Isenberg G (1994). "Native talin is a dumbbell-shaped homodimer when it interacts with actin".
7332:
7231:
7126:
7030:
6982:
6975:
6961:
6906:
6876:
6356:
6346:
6298:
6280:
6209:
6043:
5882:
5827:
429:
7071:
6761:
4453:
4139:
2189:
1487:
with many sugar 'trees' attached to them. Low-resolution images of detergent extracts of intact integrin GPIIbIIIa, obtained using
6366:
6083:
7171:
5351:
5034:
7749:
7699:
7670:
7617:
6104:
5971:
4297:
3524:
3367:
693:
453:
291:
102:
765:
525:
363:
210:
7428:
7424:
7420:
7416:
4969:
4953:
1465:
In both cases, the A-domains carry up to three divalent cation binding sites. One is permanently occupied in physiological
3178:
8046:
5697:
5616:
5483:
5400:
3877:
3385:"β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma"
8014:
7412:
1641:
7792:
7101:
6220:
5780:
5391:
4822:
2338:
2362:
Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA (October 2001).
5049:
4993:
4984:
4325:
4290:
3597:
Wagner, N.; Löhler, J.; Kunkel, E. J.; Ley, K.; Leung, E.; Krissansen, G.; Rajewsky, K.; Müller, W. (1996-07-25).
3358:
Bostwick DG, Cheng L (2020-01-01). "9 - Neoplasms of the
Prostate". In Cheng L, MacLennan GT, Bostwick DG (eds.).
8189:
8184:
7623:
4532:
4352:
7710:
7686:
6826:
6382:
6245:
1471:
1728:
Depending on the integrin's regulatory impact on specific receptor tyrosine kinases, the cell can experience:
753:
513:
351:
198:
7676:
4342:
3540:
Wang, Caihong; McDonough, Jacquelyn S.; McDonald, Keely G.; Huang, Conway; Newberry, Rodney D. (2008-09-15).
1430:. The role of divalent cations in the α subunit is unknown, but may stabilize the folds of the protein. The
8041:
7785:
7720:
6116:
5998:
5988:
2757:"The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation"
7091:
1680:
family members to phosphorylate substrates such as p130CAS thereby recruiting signaling adaptors such as
1445:, the alpha-A domain (so called because it has a similar structure to the A-domains found in the protein
1434:
in the β subunits are more interesting: they are directly involved in coordinating at least some of the
434:
7860:
7843:
7826:
7705:
5531:
4770:
3828:
829:
749:
650:
crystal structure of the filamin a repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
509:
347:
194:
8056:
8051:
7865:
7613:
2968:"Integrin Regulated Autoimmune Disorders: Understanding the Role of Mechanical Force in Autoimmunity"
1778:
1491:, and even data from indirect techniques that investigate the solution properties of integrins using
1454:
706:
466:
304:
115:
17:
8148:
7838:
5797:
5713:
5632:
5499:
5416:
4802:
3849:
2931:
Yamada KM, Miyamoto S (October 1995). "Integrin transmembrane signaling and cytoskeletal control".
1745:
7976:
7948:
7875:
7855:
7397:
5144:
5019:
3870:
1645:
818:
783:
3511:
Krieger M, Scott MP, Matsudaira PT, Lodish HF, Darnell JE, Zipursky L, Kaiser C, Berk A (2004).
7988:
7961:
7681:
7297:
7201:
6821:
6240:
5226:
4864:
4317:
1786:
1573:
1194:
1092:
1075:
832:
1364:
1348:
1332:
1315:
1299:
1282:
1265:
1248:
1211:
1177:
1160:
1143:
1126:
1109:
1058:
1042:
1025:
1008:
991:
974:
957:
940:
923:
8114:
8076:
7956:
7902:
7880:
7833:
7755:
5952:
5236:
4875:
4509:
4282:
4059:
2096:
1673:
1585:
1446:
1435:
1401:
8085:
8081:
8033:
7695:
7081:
6013:
5962:
4481:
4467:
4171:
4155:
4086:
3083:
3019:"Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis"
2375:
1601:
1536:
787:
732:
492:
330:
177:
8:
8143:
8126:
7812:
6836:
6250:
4346:
3839:
1700:
1492:
1488:
791:
146:
3087:
2379:
8179:
7777:
6514:
4867:
3863:
3756:
3731:
3709:
3644:
Elangbam CS, Qualls CW, Dahlgren RR (January 1997). "Cell adhesion molecules--update".
3574:
3541:
3463:
3438:
3409:
3384:
3259:
3234:
3155:
3106:
3071:
3043:
3018:
2994:
2967:
2908:
2881:
2822:
2797:
2675:
2612:
2488:
2396:
2363:
127:
3599:"Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue"
2662:
2645:
2621:
2596:
2475:
2458:
7993:
7141:
3845:
3802:
3761:
3701:
3661:
3626:
3618:
3579:
3561:
3520:
3513:
3468:
3414:
3363:
3335:
3300:
3264:
3215:
3147:
3111:
3048:
2999:
2948:
2944:
2913:
2862:
2827:
2778:
2737:
2702:
2667:
2626:
2577:
2523:
2480:
2436:
2401:
1774:
740:
698:
532:
500:
458:
338:
296:
185:
107:
4833:
3713:
3159:
3034:
2679:
2492:
674:
410:
260:
70:
8119:
8090:
8019:
7915:
7848:
7559:
6691:
4647:
4313:
4160:
4091:
4021:
4016:
3970:
3792:
3751:
3743:
3693:
3653:
3610:
3569:
3553:
3458:
3450:
3404:
3396:
3327:
3292:
3254:
3246:
3205:
3139:
3101:
3091:
3038:
3030:
2989:
2979:
2940:
2903:
2893:
2854:
2817:
2809:
2768:
2729:
2657:
2616:
2608:
2569:
2515:
2470:
2428:
2391:
2383:
2062:
1449:; it is also termed the α-I domain). Integrins carrying this domain either bind to
1416:
1338:
1321:
1166:
728:
488:
326:
173:
3779:
Bergh JJ, Lin HY, Lansing L, Mohamed SN, Davis FB, Mousa S, Davis PJ (July 2005).
3400:
3296:
2519:
2432:
139:
83:
7998:
3362:(Fourth ed.). Philadelphia: Content Repository Only!. pp. 415–525.e42.
3096:
1709:
1653:
880:
876:
686:
422:
272:
151:
95:
3557:
2573:
1695:
One important function of integrins on cells in tissue culture is their role in
8131:
7938:
7808:
7745:
7666:
7608:
7302:
7151:
7146:
6260:
6255:
4901:
4891:
4886:
4255:
4250:
4229:
3657:
3174:
2755:
Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH (October 1999).
2542:
2224:
2197:
2154:
1952:
1696:
1540:
1412:
891:
3835:
3437:
Nieuwenhuis B, Haenzi B, Andrews MR, Verhaagen J, Fawcett JW (February 2018).
3250:
3210:
3193:
2984:
8173:
7933:
7439:
7352:
7281:
7251:
7186:
7096:
7050:
6926:
6856:
6801:
6790:
6275:
5983:
5666:
5571:
5463:
4629:
3622:
3565:
2773:
2756:
1909:
1737:
1652:
complexes, which consist of integrins and many cytoplasmic proteins, such as
1649:
1609:
1513:
1484:
1466:
1388:
3072:"The non-equilibrium thermodynamics and kinetics of focal adhesion dynamics"
2387:
8158:
7923:
7919:
7765:
7735:
7474:
7464:
7357:
7256:
7111:
6931:
6866:
6781:
6285:
6088:
5927:
5922:
5842:
5792:
5606:
5360:
5341:
5320:
5291:
5014:
5009:
4600:
4596:
4592:
4588:
4381:
3806:
3765:
3705:
3583:
3472:
3418:
3339:
3304:
3268:
3219:
3151:
3115:
3067:
3052:
3003:
2917:
2898:
2858:
2831:
2782:
2741:
2706:
2671:
2581:
2527:
2484:
2440:
2405:
2087:
2045:
1605:
1381:
799:
3747:
3665:
3630:
3598:
3439:"Integrins promote axonal regeneration after injury of the nervous system"
2952:
2866:
2630:
702:
462:
300:
111:
8153:
7966:
7725:
7691:
7589:
7579:
7574:
7564:
7514:
7337:
7236:
6997:
6911:
6841:
6736:
6499:
6464:
6414:
6377:
6313:
6195:
6126:
6078:
6068:
6063:
6058:
5942:
5937:
5932:
5310:
5221:
5211:
5179:
5174:
5169:
5164:
5154:
5114:
5079:
4673:
4606:
4566:
4556:
3797:
3780:
2364:"Crystal structure of the extracellular segment of integrin alpha Vbeta3"
2328:
2273:
2242:
2215:
2177:
2173:
2145:
2141:
1915:
1782:
1732:
1705:
1621:
1617:
1577:
1551:
proteins have also been found to interact with integrin and activate it.
1505:
852:
848:
811:
27:
Instance of a defined set in Homo sapiens with
Reactome ID (R-HSA-374573)
3331:
2597:"Electron microscopy and structural model of human fibronectin receptor"
1692:
reduces the size of the particle, and it is extremely mechanosensitive.
8106:
7544:
7509:
7504:
7494:
7484:
7402:
7191:
7166:
7156:
7002:
6956:
6816:
6642:
6611:
6580:
6549:
6494:
6469:
6449:
6434:
6424:
6318:
6235:
6028:
6008:
5907:
5852:
5847:
5671:
5576:
5561:
5356:
5315:
5287:
5256:
5216:
5119:
5074:
5069:
5044:
5039:
5029:
4942:
4936:
4926:
4779:
4750:
4745:
4740:
4663:
4584:
2733:
2333:
2299:
2078:
1972:
1681:
1677:
1569:
1561:
1504:
integrin bound to a small ligand containing the RGD-sequence, the drug
1442:
1397:
885:
795:
446:
284:
3697:
3454:
2966:
Banerjee, S; Nara, R; Chakraborty, S; Chowdhury, D; Haldar, S (2022).
622:
616:
610:
604:
598:
592:
586:
580:
574:
568:
562:
556:
550:
544:
538:
8136:
7870:
7569:
7539:
7534:
7529:
7524:
7519:
7499:
7489:
7479:
7469:
7161:
7121:
7017:
6992:
6751:
6746:
6741:
6731:
6726:
6721:
6711:
6632:
6570:
6504:
6484:
6479:
6474:
6459:
6454:
6444:
6439:
6333:
6308:
6073:
5993:
5912:
5857:
5747:
5686:
5676:
5581:
5468:
5266:
5261:
5251:
5159:
5149:
5134:
5109:
5104:
5094:
5089:
5084:
4576:
4376:
3614:
2185:
1750:
1565:
1548:
1544:
1393:
896:
872:
3143:
2813:
2595:
Nermut MV, Green NM, Eason P, Yamada SS, Yamada KM (December 1988).
7928:
7740:
7459:
7116:
6716:
6706:
6686:
6429:
6419:
5766:
5246:
5189:
5099:
5059:
4732:
4541:
4334:
3128:
2112:
2082:
1835:
1764:
Integrins are localised at the growth cone of regenerating neurons.
1661:
1657:
1633:
1625:
1589:
1522:
1450:
1424:
1420:
856:
840:
836:
825:
807:
681:
417:
267:
90:
6621:
6590:
6559:
6523:
7910:
7715:
7136:
6601:
6003:
4964:
3436:
3383:
Carbonell WS, DeLay M, Jahangiri A, Park CC, Aghi MK (May 2013).
3065:
2720:
Calderwood DA (June 2004). "Talin controls integrin activation".
2541:
Bruce A, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002).
2323:
2305:
1839:
1689:
1665:
1629:
1405:
860:
844:
794:
pathways that mediate cellular signals such as regulation of the
441:
279:
2965:
2277:
2246:
1797:
The following are 16 of the ~24 integrins found in vertebrates:
384:
46:
Structure of the extracellular segment of integrin alpha Vbeta3.
7628:
7292:
7181:
7106:
6811:
6806:
6230:
6225:
6179:
6175:
6171:
6167:
6163:
6159:
6155:
5807:
5346:
5024:
4642:
4513:
4403:
4366:
4356:
4064:
3950:
3945:
3823:
2506:
Giancotti FG, Ruoslahti E (August 1999). "Integrin signaling".
2054:
2050:
1927:
1919:
1669:
1613:
1427:
1200:
1098:
1081:
760:
645:
520:
358:
231:
205:
41:
4312:
3233:
Moreno-Layseca P, Icha J, Hamidi H, Ivaska J (February 2019).
3232:
1584:
A prominent function of the integrins is seen in the molecule
7660:
7656:
7652:
7648:
7644:
7640:
7636:
7632:
7347:
7246:
6921:
6861:
6675:
6398:
6394:
6390:
6386:
5877:
5741:
5660:
5656:
5555:
5551:
5547:
5543:
5452:
5448:
5299:
4817:
4794:
4790:
4718:
4708:
4703:
4698:
4693:
4688:
4637:
4517:
4499:
4495:
4485:
4471:
4457:
4433:
4428:
4423:
4418:
4413:
4408:
4391:
4386:
4360:
4218:
4213:
4176:
4144:
4118:
4031:
4026:
4011:
3980:
3975:
3965:
3960:
3955:
3940:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
2181:
2029:
1893:
1500:
1423:-rich repeated sequences. Both α and β subunits bind several
1370:
1354:
1305:
1217:
1183:
1149:
1132:
1115:
1064:
1048:
1031:
1014:
997:
980:
963:
946:
929:
3855:
3510:
3166:
2879:
1708:; they are transported through the cell to its front by the
7131:
5737:
5733:
5729:
5725:
5721:
5717:
5652:
5648:
5644:
5640:
5636:
5539:
5535:
5527:
5523:
5519:
5515:
5511:
5507:
5503:
5444:
5440:
5436:
5432:
5428:
5424:
5420:
5372:
5368:
5364:
5330:
5295:
5276:
4812:
4807:
4774:
4713:
4683:
4678:
4668:
4618:
4614:
4610:
4561:
4503:
4489:
4475:
4461:
4396:
4371:
4222:
4180:
4164:
4148:
4095:
4068:
4006:
4001:
3996:
3382:
3016:
1288:
1271:
1254:
722:
669:
482:
405:
320:
255:
167:
77:
65:
3539:
2418:
2361:
3683:
3443:
Biological
Reviews of the Cambridge Philosophical Society
2646:"Integrins: bidirectional, allosteric signaling machines"
2459:"Integrins: bidirectional, allosteric signaling machines"
1431:
7807:
790:(ECM) adhesion. Upon ligand binding, integrins activate
639:
Integrin beta 7 cytoplasmic domain: complex with filamin
3729:
2880:
Harburger DS, Bouaouina M, Calderwood DA (April 2009).
2844:
2754:
7731:
Pituitary adenylate cyclase-activating peptide (PACAP)
3778:
3643:
3194:"Endocytic Trafficking of Integrins in Cell Migration"
2798:"The final steps of integrin activation: the end game"
2594:
4863:
3596:
3017:
Wilhelmsen K, Litjens SH, Sonnenberg A (April 2006).
2540:
1380:
Variants of some subunits are formed by differential
3191:
2239:
proliferating epithelia, esp. lung and mammary gland
843:, to mediate cell–cell and cell–matrix interaction.
3432:
3430:
3428:
2170:
activated endothelial cells, melanoma, glioblastoma
7677:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
6535:Glial cell line-derived neurotrophic factor (GDNF)
6188:Cleavage products/derivatives with unknown target:
3512:
3317:
3192:Paul NR, Jacquemet G, Caswell PT (November 2015).
2795:
2505:
3519:(fifth ed.). New York: W.H. Freeman and CO.
3281:
8171:
7711:Macrophage-stimulating protein (MSP; HLP, HGFLP)
3672:
3425:
3172:
3070:, Garikipati K (August 2010). Buehler MJ (ed.).
2789:
1595:
824:Integrins work alongside other proteins such as
5352:Heparin-binding EGF-like growth factor (HB-EGF)
5035:Heparin-binding EGF-like growth factor (HB-EGF)
3725:
3723:
3679:
3677:
3675:
1415:of the integrin subunits can vary from 90
1404:region for the ECM. They have been compared to
2930:
2452:
2450:
2357:
2355:
2212:widespread, esp. fibroblasts, epithelial cells
7793:
7763:Additional growth factor receptor modulators:
4849:
4298:
3871:
3357:
2796:Shattil SJ, Kim C, Ginsberg MH (April 2010).
1768:
1453:(e.g. integrins α1 β1, and α2 β1), or act as
6117:Insulin-like growth factor-2 (somatomedin A)
5999:Insulin-like growth factor-2 (somatomedin A)
5989:Insulin-like growth factor-1 (somatomedin C)
3720:
3311:
3122:
3059:
3010:
2873:
2748:
2713:
3637:
3235:"Integrin trafficking in cells and tissues"
2972:Frontiers in Cell and Developmental Biology
2838:
2693:Smith JW (June 2003). "Cilengitide Merck".
2560:Humphries MJ (2000). "Integrin structure".
2447:
2412:
2352:
1474:("RGD" in the one-letter amino acid code).
7800:
7786:
4856:
4842:
4305:
4291:
3878:
3864:
3506:
3504:
3502:
2719:
2588:
2549:(4th ed.). New York: Garland Science.
644:
383:
230:
40:
35:Integrin alphaVbeta3 extracellular domains
3848:at the U.S. National Library of Medicine
3796:
3755:
3573:
3500:
3498:
3496:
3494:
3492:
3490:
3488:
3486:
3484:
3482:
3462:
3408:
3258:
3209:
3105:
3095:
3042:
2993:
2983:
2907:
2897:
2821:
2772:
2661:
2620:
2559:
2474:
2395:
1419:to 160 kDa. Beta subunits have four
7885:
7721:Migration-stimulating factor (MSF; PRG4)
2695:Current Opinion in Investigational Drugs
1773:Integrins have an important function in
1759:
5050:Transforming growth factor alpha (TGFα)
1792:
14:
8172:
7624:Connective tissue growth factor (CTGF)
3479:
2802:Nature Reviews. Molecular Cell Biology
1715:
1588:, an integrin on the surface of blood
7781:
7687:Hepatoma-derived growth factor (HDGF)
4837:
4286:
3859:
3353:
3351:
3349:
2692:
2643:
2637:
2456:
1781:(PNS). Integrins are present at the
1462:A-domain is found on the β subunit.
798:, organization of the intracellular
236:Structure of chaperone protein PAPD.
8047:Transcription preinitiation complex
2886:The Journal of Biological Chemistry
2761:The Journal of Biological Chemistry
2553:
879:. Several genes code for multiple
24:
8015:Signal transducing adaptor protein
4273:cell surface receptor deficiencies
3346:
2613:10.1002/j.1460-2075.1988.tb03303.x
889:five α and two β subunits, and in
25:
8201:
3817:
2339:Extracellular polymeric substance
1751:apoptosis (programmed cell death)
225:Integrin alpha cytoplasmic region
7706:Leukemia inhibitory factor (LIF)
3822:
3686:Journal of Cellular Biochemistry
3181:from the original on 2010-12-02.
2722:Biochemical Society Transactions
2562:Biochemical Society Transactions
810:to initiate an interaction with
6874:Negative allosteric modulators:
3772:
3590:
3533:
3376:
3275:
3226:
3185:
3035:10.1128/MCB.26.8.2877-2886.2006
2959:
2933:Current Opinion in Cell Biology
2924:
2270:neural tissue; peripheral nerve
7192:Gossypetin (3,5,7,8,3',4'-HHF)
6383:Platelet-derived growth factor
3023:Molecular and Cellular Biology
2686:
2534:
2499:
2218:, osteopontin, and adenovirus
2109:Fibrinogen receptor; gpIIbIIIa
1477:
1472:Arginine-Glycine-Aspartic acid
13:
1:
7398:Placental growth factor (PGF)
3885:
3401:10.1158/0008-5472.CAN-13-0011
3297:10.1158/0008-5472.CAN-04-4315
2847:Journal of Structural Biology
2663:10.1016/S0092-8674(02)00971-6
2547:Molecular Biology of the Cell
2520:10.1126/science.285.5430.1028
2476:10.1016/s0092-8674(02)00971-6
2433:10.1126/science.285.5430.1058
2345:
1596:Attachment of cell to the ECM
1529:
786:that help cell-cell and cell-
717:Available protein structures:
477:Available protein structures:
315:Available protein structures:
162:Available protein structures:
7682:Glia maturation factor (GMF)
6191:Glypromate (GPE, (1-3)IGF-1)
4133:Leukocyte-adhesion receptor:
3320:The Journal of Endocrinology
3173:Gullingsrud J, Sotomayor M.
3097:10.1371/journal.pone.0012043
2945:10.1016/0955-0674(95)80110-3
1604:(ECM) outside a cell to the
866:
7:
4192:Very late antigen receptor:
3836:Talin substrate for calpain
3736:The Journal of Cell Biology
3558:10.4049/jimmunol.181.6.4052
3360:Urologic Surgical Pathology
3175:"Mechanosensitive channels"
3066:Olberding JE, Thouless MD,
2644:Hynes RO (September 2002).
2457:Hynes RO (September 2002).
2317:
2176:, fibronectin, fibrinogen,
1965:VLA-5; fibronectin receptor
1554:
1387:Integrin subunits span the
10:
8206:
7614:Colony-stimulating factors
7606:Additional growth factors:
4771:Lymphocyte homing receptor
3658:10.1177/030098589703400113
1769:Integrins and nerve repair
1668:. These act by regulating
1600:Integrins couple the cell-
830:immunoglobulin superfamily
821:are found in plant cells.
378:Integrin, beta chain (vWA)
8099:
8069:
8032:
8007:
7984:
7975:
7947:
7901:
7894:
7819:
7598:
7385:
7280:
7049:
6962:SNA-120 (pegylated K252a)
6789:
6780:
6760:
6674:
6651:
6620:
6589:
6558:
6522:
6513:
6365:
6208:
6141:
6134:(against IGF-1 and IGF-2)
6103:
6096:(against IGF-1 and IGF-2)
5970:
5961:
5779:
5756:
5696:
5615:
5482:
5399:
5390:
5329:
5275:
5188:
4992:
4983:
4952:
4874:
4763:
4731:
4656:
4628:
4575:
4549:
4540:
4531:
4444:
4333:
4324:
4268:
4243:
4191:
4132:
4106:
4079:
4047:
4040:
3989:
3893:
3251:10.1038/s41556-018-0223-z
3211:10.1016/j.cub.2015.09.049
2985:10.3389/fcell.2022.852878
2574:10.1042/0300-5127:0280311
1779:peripheral nervous system
759:
739:
721:
716:
712:
692:
680:
668:
660:
655:
643:
638:
531:
519:
499:
481:
476:
472:
452:
440:
428:
416:
404:
396:
391:
382:
377:
357:
337:
319:
314:
310:
290:
278:
266:
254:
246:
241:
229:
224:
204:
184:
166:
161:
157:
145:
133:
121:
101:
89:
76:
64:
56:
51:
39:
34:
8127:Neuroendocrine signaling
5798:Hepatocyte growth factor
5357:Neuregulins (heregulins)
5288:Neuregulins (heregulins)
5232:Trastuzumab duocarmazine
4945:(against angiopoietin 2)
4939:(against angiopoietin 3)
4803:Carcinoembryonic antigen
4657:Unconventional/ungrouped
3850:Medical Subject Headings
2774:10.1074/jbc.274.40.28071
2117:fibrinogen, fibronectin
1746:cellular differentiation
5145:Depatuxizumab mafodotin
4318:cell adhesion molecules
2388:10.1126/science.1064535
1993:VLA-6; laminin receptor
871:Integrins are obligate
833:cell adhesion molecules
819:integrin-like receptors
784:transmembrane receptors
8190:Cell adhesion proteins
8185:Transmembrane proteins
7989:cAMP-dependent pathway
7768:(neurotrophin mixture)
7756:Wnt signaling proteins
7437:Allosteric modulators:
7157:Norwogonin (5,7,8-THF)
5377:5 (tomoregulin, TMEFF)
5227:Trastuzumab deruxtecan
4865:Growth factor receptor
3515:Molecular cell biology
2899:10.1074/jbc.M809233200
2859:10.1006/jsbi.1994.1002
1787:central nervous system
1765:
1574:foot-and-mouth disease
1400:of each chain forms a
1396:; the final 5 nm
847:for integrins include
8115:Synaptic transmission
8111:Neurocrine signaling
8034:Transcription factors
7881:PI3K/AKT/mTOR pathway
7696:T-cell growth factors
5953:Telisotuzumab vedotin
5237:Trastuzumab emtansine
4510:Glycoprotein IIb/IIIa
4244:Vitronectin receptor:
4107:Fibronectin receptor:
4060:Glycoprotein IIb/IIIa
4048:Cytoadhesin receptor:
3831:at Wikimedia Commons
3748:10.1083/jcb.144.4.767
3546:Journal of Immunology
1763:
1674:focal adhesion kinase
1447:von Willebrand factor
1438:that integrins bind.
6281:EVT-901 (SAR-127963)
6014:Mecasermin rinfabate
4482:Macrophage-1 antigen
4468:Integrin alphaXbeta2
4235:Integrin alpha6beta1
4209:Integrin alpha3beta1
4204:Integrin alpha2beta1
4199:Integrin alpha1beta1
4172:Integrin alphaXbeta2
4156:Macrophage-1 antigen
4124:Integrin alpha5beta1
4119:Integrin alpha4beta1
4114:Integrin alpha2beta1
4087:Macrophage-1 antigen
4080:Fibrinogen receptor:
4055:Integrin alpha6beta4
3798:10.1210/en.2005-0102
3646:Veterinary Pathology
2167:vitronectin receptor
1864:Collagens, laminins
1793:Vertebrate integrins
1777:after injury of the
1699:. Cells adhere to a
1608:(in particular, the
1602:extracellular matrix
875:composed of α and β
788:extracellular matrix
60:Integrin_alphaVbeta3
8144:Mechanotransduction
8132:Exocrine signalling
7939:Signaling molecules
7813:Signal transduction
4347:Myelin protein zero
4326:Calcium-independent
3840:The Proteolysis Map
3332:10.1530/JOE-10-0377
3239:Nature Cell Biology
3132:Nature Cell Biology
3088:2010PLoSO...512043O
2380:2001Sci...294..339X
2138:neurological tumors
1716:Signal transduction
1493:ultracentrifugation
1489:electron microscopy
1276:LFA-1, MAC-1, MFI7
1232:
907:
792:signal transduction
8154:Ion channel gating
7886:Integrin receptors
7820:Signaling pathways
7447:Kinase inhibitors:
7310:Kinase inhibitors:
7209:Kinase inhibitors:
6884:Kinase inhibitors:
6699:Kinase inhibitors:
6659:Kinase inhibitors:
6640:Kinase inhibitors:
6609:Kinase inhibitors:
6578:Kinase inhibitors:
6547:Kinase inhibitors:
6407:Kinase inhibitors:
6021:Kinase inhibitors:
5815:Kinase inhibitors:
5604:Kinase inhibitors:
5597:Aprutumab ixadotin
5244:Kinase inhibitors:
5057:Kinase inhibitors:
4914:Kinase inhibitors:
2734:10.1042/BST0320434
1766:
1259:FNRB, MSK12, MDF2
1227:
902:
8167:
8166:
8149:Phototransduction
8107:Intracrine action
8065:
8064:
8028:
8027:
7916:Neurotransmitters
7775:
7774:
7381:
7380:
7142:N-Acetylserotonin
7041:ReN-1820 (TrkAd5)
6670:
6669:
6204:
6203:
6149:Binding proteins:
5808:Dihexa (PNB-0408)
5775:
5774:
5386:
5385:
5300:6 (neuroglycan C)
5020:EGF (urogastrone)
4998:
4831:
4830:
4759:
4758:
4727:
4726:
4533:Calcium-dependent
4527:
4526:
4314:Membrane proteins
4280:
4279:
4264:
4263:
3827:Media related to
3698:10.1002/jcb.21558
3609:(6589): 366–370.
3526:978-0-7167-4366-8
3455:10.1111/brv.12398
3369:978-0-323-54941-7
3204:(22): R1092-105.
2514:(5430): 1028–32.
2427:(5430): 1058–61.
2311:
2310:
2090:proteins, ICAM-1
1775:neuroregeneration
1616:of integrins are
1378:
1377:
1225:
1224:
775:
774:
771:
770:
766:structure summary
634:
633:
630:
629:
526:structure summary
373:
372:
369:
368:
364:structure summary
220:
219:
216:
215:
211:structure summary
16:(Redirected from
8197:
8120:Chemical synapse
8020:Scaffold protein
7982:
7981:
7977:Second messenger
7903:Receptor ligands
7899:
7898:
7802:
7795:
7788:
7779:
7778:
7587:Decoy receptors:
7560:Alacizumab pegol
7038:Decoy receptors:
6787:
6786:
6692:Stem cell factor
6633:Persephin (PSPN)
6571:Neurturin (NRTN)
6520:
6519:
6357:LEVI-04 (p75-Fc)
6354:Decoy receptors:
5968:
5967:
5397:
5396:
4996:
4990:
4989:
4858:
4851:
4844:
4835:
4834:
4547:
4546:
4538:
4537:
4331:
4330:
4307:
4300:
4293:
4284:
4283:
4045:
4044:
3880:
3873:
3866:
3857:
3856:
3826:
3811:
3810:
3800:
3776:
3770:
3769:
3759:
3727:
3718:
3717:
3681:
3670:
3669:
3641:
3635:
3634:
3615:10.1038/382366a0
3594:
3588:
3587:
3577:
3552:(6): 4052–4061.
3537:
3531:
3530:
3518:
3508:
3477:
3476:
3466:
3449:(3): 1339–1362.
3434:
3423:
3422:
3412:
3380:
3374:
3373:
3355:
3344:
3343:
3315:
3309:
3308:
3291:(15): 6692–700.
3279:
3273:
3272:
3262:
3230:
3224:
3223:
3213:
3189:
3183:
3182:
3170:
3164:
3163:
3126:
3120:
3119:
3109:
3099:
3063:
3057:
3056:
3046:
3014:
3008:
3007:
2997:
2987:
2963:
2957:
2956:
2928:
2922:
2921:
2911:
2901:
2892:(17): 11485–97.
2877:
2871:
2870:
2842:
2836:
2835:
2825:
2793:
2787:
2786:
2776:
2752:
2746:
2745:
2717:
2711:
2710:
2690:
2684:
2683:
2665:
2641:
2635:
2634:
2624:
2601:The EMBO Journal
2592:
2586:
2585:
2557:
2551:
2550:
2538:
2532:
2531:
2503:
2497:
2496:
2478:
2454:
2445:
2444:
2416:
2410:
2409:
2399:
2374:(5541): 339–45.
2359:
1971:fibronectin and
1800:
1799:
1543:. Recently, the
1233:
1231:
1226:
908:
906:
901:
714:
713:
648:
636:
635:
625:
619:
613:
607:
601:
595:
589:
583:
577:
571:
565:
559:
553:
547:
541:
474:
473:
387:
375:
374:
312:
311:
234:
222:
221:
159:
158:
44:
32:
31:
21:
8205:
8204:
8200:
8199:
8198:
8196:
8195:
8194:
8170:
8169:
8168:
8163:
8095:
8061:
8024:
8003:
7999:Lipid signaling
7971:
7943:
7890:
7815:
7806:
7776:
7771:
7716:Midkine (NEGF2)
7594:
7377:
7276:
7045:
6983:ABT-110 (PG110)
6776:
6756:
6666:
6647:
6616:
6585:
6554:
6509:
6361:
6299:ABT-110 (PG110)
6200:
6137:
6099:
5957:
5771:
5752:
5692:
5689:(against FGF23)
5611:
5478:
5382:
5325:
5271:
5184:
4995:
4979:
4948:
4870:
4862:
4832:
4827:
4755:
4723:
4652:
4624:
4571:
4523:
4440:
4320:
4311:
4281:
4276:
4260:
4239:
4187:
4128:
4102:
4075:
4036:
3985:
3889:
3884:
3820:
3815:
3814:
3777:
3773:
3728:
3721:
3682:
3673:
3642:
3638:
3595:
3591:
3538:
3534:
3527:
3509:
3480:
3435:
3426:
3395:(10): 3145–54.
3389:Cancer Research
3381:
3377:
3370:
3356:
3347:
3316:
3312:
3285:Cancer Research
3280:
3276:
3231:
3227:
3198:Current Biology
3190:
3186:
3171:
3167:
3144:10.1038/ncb2095
3127:
3123:
3064:
3060:
3015:
3011:
2964:
2960:
2929:
2925:
2878:
2874:
2843:
2839:
2814:10.1038/nrm2871
2794:
2790:
2767:(40): 28071–4.
2753:
2749:
2718:
2714:
2691:
2687:
2642:
2638:
2593:
2589:
2558:
2554:
2539:
2535:
2504:
2500:
2455:
2448:
2417:
2413:
2360:
2353:
2348:
2320:
2293:
2289:
2263:
2259:
2232:
2228:
2205:
2201:
2162:
2158:
2131:
2127:
2104:
2100:
2070:
2066:
2037:
2033:
2013:
2009:
1988:
1984:
1960:
1956:
1935:
1931:
1901:
1897:
1877:
1873:
1854:
1850:
1825:
1821:
1795:
1771:
1718:
1710:endocytic cycle
1598:
1557:
1532:
1480:
1229:
904:
869:
777:
776:
651:
621:
615:
609:
603:
597:
591:
585:
579:
573:
567:
561:
555:
549:
543:
537:
237:
123:OPM superfamily
47:
28:
23:
22:
15:
12:
11:
5:
8203:
8193:
8192:
8187:
8182:
8165:
8164:
8162:
8161:
8156:
8151:
8146:
8141:
8140:
8139:
8129:
8124:
8123:
8122:
8117:
8109:
8103:
8101:
8100:Other concepts
8097:
8096:
8094:
8093:
8088:
8079:
8073:
8071:
8067:
8066:
8063:
8062:
8060:
8059:
8054:
8049:
8044:
8038:
8036:
8030:
8029:
8026:
8025:
8023:
8022:
8017:
8011:
8009:
8005:
8004:
8002:
8001:
7996:
7991:
7985:
7979:
7973:
7972:
7970:
7969:
7964:
7959:
7953:
7951:
7945:
7944:
7942:
7941:
7936:
7934:Growth factors
7931:
7926:
7913:
7907:
7905:
7896:
7892:
7891:
7889:
7888:
7883:
7878:
7873:
7868:
7863:
7858:
7853:
7852:
7851:
7846:
7836:
7831:
7829:
7823:
7821:
7817:
7816:
7809:Cell signaling
7805:
7804:
7797:
7790:
7782:
7773:
7772:
7770:
7769:
7759:
7758:
7753:
7746:Thrombopoietin
7743:
7738:
7733:
7728:
7723:
7718:
7713:
7708:
7703:
7689:
7684:
7679:
7674:
7667:Erythropoietin
7664:
7626:
7621:
7611:
7609:Adrenomedullin
7602:
7600:
7596:
7595:
7593:
7592:
7583:
7582:
7577:
7572:
7567:
7562:
7553:
7552:
7547:
7542:
7537:
7532:
7527:
7522:
7517:
7512:
7507:
7502:
7497:
7492:
7487:
7482:
7477:
7472:
7467:
7462:
7457:
7452:
7443:
7442:
7433:
7432:
7410:
7405:
7400:
7391:
7389:
7383:
7382:
7379:
7378:
7376:
7375:
7370:
7365:
7360:
7355:
7350:
7345:
7340:
7335:
7330:
7325:
7320:
7315:
7306:
7305:
7300:
7295:
7286:
7284:
7278:
7277:
7275:
7274:
7269:
7264:
7259:
7254:
7249:
7244:
7239:
7234:
7229:
7224:
7219:
7214:
7205:
7204:
7195:
7194:
7189:
7184:
7175:
7174:
7169:
7164:
7159:
7154:
7149:
7144:
7139:
7134:
7129:
7124:
7119:
7114:
7109:
7104:
7099:
7094:
7089:
7084:
7079:
7074:
7072:4'-DMA-7,8-DHF
7069:
7064:
7055:
7053:
7047:
7046:
7044:
7043:
7034:
7033:
7021:
7020:
7015:
7010:
7005:
7000:
6995:
6990:
6985:
6966:
6965:
6959:
6954:
6949:
6944:
6939:
6934:
6929:
6924:
6919:
6914:
6909:
6904:
6899:
6894:
6889:
6880:
6879:
6870:
6869:
6864:
6859:
6854:
6845:
6844:
6839:
6834:
6832:Gambogic amide
6829:
6824:
6819:
6814:
6809:
6804:
6795:
6793:
6784:
6778:
6777:
6775:
6774:
6766:
6764:
6758:
6757:
6755:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6695:
6694:
6689:
6680:
6678:
6672:
6671:
6668:
6667:
6665:
6664:
6655:
6653:
6649:
6648:
6646:
6645:
6636:
6635:
6626:
6624:
6618:
6617:
6615:
6614:
6605:
6604:
6602:Artemin (ARTN)
6595:
6593:
6587:
6586:
6584:
6583:
6574:
6573:
6564:
6562:
6556:
6555:
6553:
6552:
6543:
6542:
6537:
6528:
6526:
6517:
6511:
6510:
6508:
6507:
6502:
6497:
6488:
6487:
6482:
6477:
6472:
6467:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6427:
6422:
6417:
6412:
6403:
6402:
6380:
6371:
6369:
6363:
6362:
6360:
6359:
6350:
6349:
6337:
6336:
6331:
6326:
6321:
6316:
6311:
6306:
6301:
6289:
6288:
6283:
6278:
6273:
6264:
6263:
6258:
6253:
6248:
6243:
6238:
6233:
6228:
6223:
6214:
6212:
6206:
6205:
6202:
6201:
6199:
6198:
6193:
6184:
6183:
6145:
6143:
6139:
6138:
6136:
6135:
6129:
6120:
6119:
6109:
6107:
6101:
6100:
6098:
6097:
6091:
6086:
6081:
6076:
6071:
6066:
6061:
6056:
6047:
6046:
6041:
6036:
6031:
6026:
6017:
6016:
6011:
6006:
6001:
5996:
5991:
5986:
5976:
5974:
5965:
5959:
5958:
5956:
5955:
5950:
5945:
5940:
5935:
5930:
5925:
5916:
5915:
5910:
5905:
5900:
5895:
5890:
5885:
5880:
5875:
5870:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5825:
5820:
5811:
5810:
5801:
5800:
5795:
5785:
5783:
5777:
5776:
5773:
5772:
5770:
5769:
5760:
5758:
5754:
5753:
5751:
5750:
5745:
5711:
5702:
5700:
5694:
5693:
5691:
5690:
5680:
5679:
5674:
5669:
5664:
5630:
5621:
5619:
5613:
5612:
5610:
5609:
5600:
5599:
5594:
5585:
5584:
5579:
5574:
5569:
5564:
5559:
5497:
5488:
5486:
5480:
5479:
5477:
5476:
5471:
5466:
5461:
5456:
5414:
5405:
5403:
5394:
5388:
5387:
5384:
5383:
5381:
5380:
5354:
5349:
5344:
5335:
5333:
5327:
5326:
5324:
5323:
5318:
5313:
5304:
5303:
5281:
5279:
5273:
5272:
5270:
5269:
5264:
5259:
5254:
5249:
5240:
5239:
5234:
5229:
5224:
5219:
5214:
5205:
5204:
5194:
5192:
5186:
5185:
5183:
5182:
5177:
5172:
5167:
5162:
5157:
5152:
5147:
5142:
5137:
5128:
5127:
5122:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5053:
5052:
5047:
5042:
5037:
5032:
5027:
5022:
5017:
5012:
5002:
5000:
4987:
4981:
4980:
4978:
4977:
4972:
4967:
4958:
4956:
4950:
4949:
4947:
4946:
4940:
4930:
4929:
4924:
4919:
4910:
4909:
4907:Angiopoietin 3
4904:
4902:Angiopoietin 2
4895:
4894:
4892:Angiopoietin 4
4889:
4887:Angiopoietin 1
4880:
4878:
4872:
4871:
4861:
4860:
4853:
4846:
4838:
4829:
4828:
4826:
4825:
4820:
4815:
4810:
4805:
4799:
4798:
4782:
4777:
4767:
4765:
4761:
4760:
4757:
4756:
4754:
4753:
4748:
4743:
4737:
4735:
4729:
4728:
4725:
4724:
4722:
4721:
4716:
4711:
4706:
4701:
4696:
4691:
4686:
4681:
4676:
4671:
4666:
4660:
4658:
4654:
4653:
4651:
4650:
4645:
4640:
4634:
4632:
4626:
4625:
4623:
4622:
4604:
4581:
4579:
4573:
4572:
4570:
4569:
4564:
4559:
4553:
4551:
4544:
4535:
4529:
4528:
4525:
4524:
4522:
4521:
4507:
4493:
4479:
4465:
4450:
4448:
4442:
4441:
4439:
4438:
4437:
4436:
4431:
4426:
4421:
4416:
4411:
4401:
4400:
4399:
4394:
4389:
4384:
4374:
4369:
4364:
4350:
4339:
4337:
4328:
4322:
4321:
4310:
4309:
4302:
4295:
4287:
4278:
4277:
4269:
4266:
4265:
4262:
4261:
4259:
4258:
4256:Alpha-v beta-5
4253:
4251:Alpha-v beta-3
4247:
4245:
4241:
4240:
4238:
4237:
4232:
4230:Alpha-5 beta-1
4227:
4226:
4225:
4211:
4206:
4201:
4195:
4193:
4189:
4188:
4186:
4185:
4184:
4183:
4169:
4168:
4167:
4153:
4152:
4151:
4136:
4134:
4130:
4129:
4127:
4126:
4121:
4116:
4110:
4108:
4104:
4103:
4101:
4100:
4099:
4098:
4083:
4081:
4077:
4076:
4074:
4073:
4072:
4071:
4057:
4051:
4049:
4042:
4038:
4037:
4035:
4034:
4029:
4024:
4019:
4014:
4009:
4004:
3999:
3993:
3991:
3987:
3986:
3984:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3897:
3895:
3891:
3890:
3883:
3882:
3875:
3868:
3860:
3854:
3853:
3843:
3819:
3818:External links
3816:
3813:
3812:
3791:(7): 2864–71.
3771:
3719:
3671:
3636:
3589:
3532:
3525:
3478:
3424:
3375:
3368:
3345:
3310:
3274:
3245:(2): 122–132.
3225:
3184:
3165:
3121:
3058:
3029:(8): 2877–86.
3009:
2958:
2923:
2872:
2837:
2808:(4): 288–300.
2788:
2747:
2728:(Pt3): 434–7.
2712:
2685:
2636:
2607:(13): 4093–9.
2587:
2552:
2533:
2498:
2446:
2411:
2350:
2349:
2347:
2344:
2343:
2342:
2336:
2331:
2326:
2319:
2316:
2309:
2308:
2303:
2297:
2295:
2291:
2287:
2282:
2281:
2271:
2268:
2266:
2261:
2257:
2251:
2250:
2240:
2237:
2235:
2230:
2226:
2220:
2219:
2213:
2210:
2208:
2203:
2199:
2193:
2192:
2171:
2168:
2165:
2160:
2156:
2150:
2149:
2139:
2136:
2134:
2129:
2125:
2119:
2118:
2115:
2110:
2107:
2102:
2098:
2092:
2091:
2085:
2076:
2073:
2068:
2064:
2058:
2057:
2048:
2043:
2040:
2035:
2031:
2025:
2024:
2021:
2020:muscle, glioma
2018:
2016:
2011:
2007:
2001:
2000:
1997:
1994:
1991:
1986:
1982:
1976:
1975:
1969:
1966:
1963:
1958:
1954:
1948:
1947:
1944:
1941:
1938:
1933:
1929:
1923:
1922:
1913:
1907:
1904:
1899:
1895:
1889:
1888:
1885:
1882:
1879:
1875:
1871:
1866:
1865:
1862:
1859:
1856:
1852:
1848:
1843:
1842:
1833:
1830:
1827:
1823:
1819:
1814:
1813:
1810:
1807:
1804:
1794:
1791:
1770:
1767:
1754:
1753:
1748:
1743:
1740:
1735:
1717:
1714:
1697:cell migration
1610:microfilaments
1597:
1594:
1556:
1553:
1541:focal adhesion
1531:
1528:
1479:
1476:
1467:concentrations
1413:molecular mass
1402:ligand-binding
1376:
1375:
1373:
1368:
1360:
1359:
1357:
1352:
1344:
1343:
1341:
1336:
1328:
1327:
1324:
1319:
1311:
1310:
1308:
1303:
1295:
1294:
1291:
1286:
1278:
1277:
1274:
1269:
1261:
1260:
1257:
1252:
1244:
1243:
1240:
1237:
1223:
1222:
1220:
1215:
1207:
1206:
1203:
1198:
1190:
1189:
1186:
1181:
1173:
1172:
1169:
1164:
1156:
1155:
1152:
1147:
1139:
1138:
1135:
1130:
1122:
1121:
1118:
1113:
1105:
1104:
1101:
1096:
1088:
1087:
1084:
1079:
1071:
1070:
1067:
1062:
1054:
1053:
1051:
1046:
1038:
1037:
1034:
1029:
1021:
1020:
1017:
1012:
1004:
1003:
1000:
995:
987:
986:
983:
978:
970:
969:
966:
961:
953:
952:
949:
944:
936:
935:
932:
927:
919:
918:
915:
912:
892:Caenorhabditis
868:
865:
773:
772:
769:
768:
763:
757:
756:
743:
737:
736:
726:
719:
718:
710:
709:
696:
690:
689:
684:
678:
677:
672:
666:
665:
664:Integrin_b_cyt
662:
658:
657:
653:
652:
649:
641:
640:
632:
631:
628:
627:
535:
529:
528:
523:
517:
516:
503:
497:
496:
486:
479:
478:
470:
469:
456:
450:
449:
444:
438:
437:
432:
426:
425:
420:
414:
413:
408:
402:
401:
398:
394:
393:
389:
388:
380:
379:
371:
370:
367:
366:
361:
355:
354:
341:
335:
334:
324:
317:
316:
308:
307:
294:
288:
287:
282:
276:
275:
270:
264:
263:
258:
252:
251:
250:Integrin_alpha
248:
244:
243:
239:
238:
235:
227:
226:
218:
217:
214:
213:
208:
202:
201:
188:
182:
181:
171:
164:
163:
155:
154:
149:
143:
142:
137:
131:
130:
125:
119:
118:
105:
99:
98:
93:
87:
86:
81:
74:
73:
68:
62:
61:
58:
54:
53:
49:
48:
45:
37:
36:
30:
29:
26:
9:
6:
4:
3:
2:
8202:
8191:
8188:
8186:
8183:
8181:
8178:
8177:
8175:
8160:
8157:
8155:
8152:
8150:
8147:
8145:
8142:
8138:
8135:
8134:
8133:
8130:
8128:
8125:
8121:
8118:
8116:
8113:
8112:
8110:
8108:
8105:
8104:
8102:
8098:
8092:
8089:
8087:
8083:
8080:
8078:
8075:
8074:
8072:
8068:
8058:
8055:
8053:
8050:
8048:
8045:
8043:
8040:
8039:
8037:
8035:
8031:
8021:
8018:
8016:
8013:
8012:
8010:
8006:
8000:
7997:
7995:
7992:
7990:
7987:
7986:
7983:
7980:
7978:
7974:
7968:
7965:
7963:
7962:Intracellular
7960:
7958:
7955:
7954:
7952:
7950:
7946:
7940:
7937:
7935:
7932:
7930:
7927:
7925:
7924:Neurohormones
7921:
7920:Neuropeptides
7917:
7914:
7912:
7909:
7908:
7906:
7904:
7900:
7897:
7893:
7887:
7884:
7882:
7879:
7877:
7874:
7872:
7871:Fas apoptosis
7869:
7867:
7864:
7862:
7859:
7857:
7854:
7850:
7847:
7845:
7842:
7841:
7840:
7837:
7835:
7832:
7830:
7828:
7825:
7824:
7822:
7818:
7814:
7810:
7803:
7798:
7796:
7791:
7789:
7784:
7783:
7780:
7767:
7764:
7761:
7760:
7757:
7754:
7751:
7747:
7744:
7742:
7739:
7737:
7734:
7732:
7729:
7727:
7724:
7722:
7719:
7717:
7714:
7712:
7709:
7707:
7704:
7701:
7697:
7693:
7690:
7688:
7685:
7683:
7680:
7678:
7675:
7672:
7668:
7665:
7662:
7658:
7654:
7650:
7646:
7642:
7638:
7634:
7630:
7627:
7625:
7622:
7619:
7615:
7612:
7610:
7607:
7604:
7603:
7601:
7597:
7591:
7588:
7585:
7584:
7581:
7578:
7576:
7573:
7571:
7568:
7566:
7563:
7561:
7558:
7555:
7554:
7551:
7548:
7546:
7543:
7541:
7538:
7536:
7533:
7531:
7528:
7526:
7523:
7521:
7518:
7516:
7513:
7511:
7508:
7506:
7503:
7501:
7498:
7496:
7493:
7491:
7488:
7486:
7483:
7481:
7478:
7476:
7473:
7471:
7468:
7466:
7463:
7461:
7458:
7456:
7453:
7451:
7448:
7445:
7444:
7441:
7440:Cyclotraxin B
7438:
7435:
7434:
7430:
7426:
7422:
7418:
7414:
7411:
7409:
7406:
7404:
7401:
7399:
7396:
7393:
7392:
7390:
7388:
7384:
7374:
7371:
7369:
7366:
7364:
7361:
7359:
7356:
7354:
7353:Larotrectinib
7351:
7349:
7346:
7344:
7341:
7339:
7336:
7334:
7331:
7329:
7326:
7324:
7321:
7319:
7316:
7314:
7311:
7308:
7307:
7304:
7301:
7299:
7296:
7294:
7291:
7288:
7287:
7285:
7283:
7279:
7273:
7270:
7268:
7265:
7263:
7260:
7258:
7255:
7253:
7252:Larotrectinib
7250:
7248:
7245:
7243:
7240:
7238:
7235:
7233:
7230:
7228:
7225:
7223:
7220:
7218:
7215:
7213:
7210:
7207:
7206:
7203:
7200:
7197:
7196:
7193:
7190:
7188:
7187:Cyclotraxin B
7185:
7183:
7180:
7177:
7176:
7173:
7170:
7168:
7165:
7163:
7160:
7158:
7155:
7153:
7150:
7148:
7145:
7143:
7140:
7138:
7135:
7133:
7130:
7128:
7125:
7123:
7120:
7118:
7115:
7113:
7110:
7108:
7105:
7103:
7100:
7098:
7097:Amitriptyline
7095:
7093:
7090:
7088:
7085:
7083:
7080:
7078:
7075:
7073:
7070:
7068:
7065:
7063:
7060:
7057:
7056:
7054:
7052:
7048:
7042:
7039:
7036:
7035:
7032:
7029:
7026:
7023:
7022:
7019:
7016:
7014:
7011:
7009:
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6977:
6974:
6973:Against TrkA:
6971:
6968:
6967:
6963:
6960:
6958:
6955:
6953:
6950:
6948:
6945:
6943:
6940:
6938:
6935:
6933:
6930:
6928:
6927:Larotrectinib
6925:
6923:
6920:
6918:
6915:
6913:
6910:
6908:
6905:
6903:
6900:
6898:
6895:
6893:
6890:
6888:
6885:
6882:
6881:
6878:
6875:
6872:
6871:
6868:
6865:
6863:
6860:
6858:
6857:Dexamethasone
6855:
6853:
6850:
6847:
6846:
6843:
6840:
6838:
6835:
6833:
6830:
6828:
6825:
6823:
6820:
6818:
6815:
6813:
6810:
6808:
6805:
6803:
6802:Amitriptyline
6800:
6797:
6796:
6794:
6792:
6788:
6785:
6783:
6779:
6772:
6768:
6767:
6765:
6763:
6759:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6705:
6703:
6700:
6697:
6696:
6693:
6690:
6688:
6685:
6682:
6681:
6679:
6677:
6673:
6663:
6660:
6657:
6656:
6654:
6650:
6644:
6641:
6638:
6637:
6634:
6631:
6628:
6627:
6625:
6623:
6619:
6613:
6610:
6607:
6606:
6603:
6600:
6597:
6596:
6594:
6592:
6588:
6582:
6579:
6576:
6575:
6572:
6569:
6566:
6565:
6563:
6561:
6557:
6551:
6548:
6545:
6544:
6541:
6538:
6536:
6533:
6530:
6529:
6527:
6525:
6521:
6518:
6516:
6512:
6506:
6503:
6501:
6498:
6496:
6493:
6490:
6489:
6486:
6483:
6481:
6478:
6476:
6473:
6471:
6468:
6466:
6463:
6461:
6458:
6456:
6453:
6451:
6448:
6446:
6443:
6441:
6438:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6416:
6413:
6411:
6408:
6405:
6404:
6400:
6396:
6392:
6388:
6384:
6381:
6379:
6376:
6373:
6372:
6370:
6368:
6364:
6358:
6355:
6352:
6351:
6348:
6345:
6342:
6339:
6338:
6335:
6332:
6330:
6327:
6325:
6322:
6320:
6317:
6315:
6312:
6310:
6307:
6305:
6302:
6300:
6297:
6294:
6291:
6290:
6287:
6284:
6282:
6279:
6277:
6276:Dexamethasone
6274:
6272:
6269:
6266:
6265:
6262:
6259:
6257:
6254:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6216:
6215:
6213:
6211:
6207:
6197:
6194:
6192:
6189:
6186:
6185:
6181:
6177:
6173:
6169:
6165:
6161:
6157:
6153:
6150:
6147:
6146:
6144:
6140:
6133:
6130:
6128:
6125:
6122:
6121:
6118:
6114:
6111:
6110:
6108:
6106:
6102:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6065:
6062:
6060:
6057:
6055:
6052:
6049:
6048:
6045:
6042:
6040:
6037:
6035:
6032:
6030:
6027:
6025:
6022:
6019:
6018:
6015:
6012:
6010:
6007:
6005:
6002:
6000:
5997:
5995:
5992:
5990:
5987:
5985:
5984:des(1-3)IGF-1
5981:
5978:
5977:
5975:
5973:
5969:
5966:
5964:
5960:
5954:
5951:
5949:
5948:Telisotuzumab
5946:
5944:
5941:
5939:
5936:
5934:
5931:
5929:
5926:
5924:
5921:
5918:
5917:
5914:
5911:
5909:
5906:
5904:
5901:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5813:
5812:
5809:
5806:
5805:Potentiators:
5803:
5802:
5799:
5796:
5794:
5790:
5787:
5786:
5784:
5782:
5778:
5768:
5765:
5762:
5761:
5759:
5755:
5749:
5746:
5743:
5739:
5735:
5731:
5727:
5723:
5719:
5715:
5712:
5710:
5707:
5704:
5703:
5701:
5699:
5695:
5688:
5685:
5682:
5681:
5678:
5675:
5673:
5670:
5668:
5667:Selpercatinib
5665:
5662:
5658:
5654:
5650:
5646:
5642:
5638:
5634:
5631:
5629:
5626:
5623:
5622:
5620:
5618:
5614:
5608:
5605:
5602:
5601:
5598:
5595:
5593:
5590:
5587:
5586:
5583:
5580:
5578:
5575:
5573:
5572:Selpercatinib
5570:
5568:
5565:
5563:
5560:
5557:
5553:
5549:
5545:
5541:
5537:
5533:
5529:
5525:
5521:
5517:
5513:
5509:
5505:
5501:
5498:
5496:
5493:
5490:
5489:
5487:
5485:
5481:
5475:
5472:
5470:
5467:
5465:
5464:Selpercatinib
5462:
5460:
5457:
5454:
5450:
5446:
5442:
5438:
5434:
5430:
5426:
5422:
5418:
5415:
5413:
5410:
5407:
5406:
5404:
5402:
5398:
5395:
5393:
5389:
5378:
5374:
5370:
5366:
5362:
5358:
5355:
5353:
5350:
5348:
5345:
5343:
5340:
5337:
5336:
5334:
5332:
5328:
5322:
5319:
5317:
5314:
5312:
5309:
5306:
5305:
5301:
5297:
5293:
5289:
5286:
5283:
5282:
5280:
5278:
5274:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5242:
5241:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5207:
5206:
5203:
5199:
5196:
5195:
5193:
5191:
5187:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5140:Depatuxizumab
5138:
5136:
5133:
5130:
5129:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5055:
5054:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5007:
5004:
5003:
5001:
4999:
4991:
4988:
4986:
4982:
4976:
4973:
4971:
4968:
4966:
4963:
4960:
4959:
4957:
4955:
4951:
4944:
4941:
4938:
4935:
4932:
4931:
4928:
4925:
4923:
4920:
4918:
4915:
4912:
4911:
4908:
4905:
4903:
4900:
4897:
4896:
4893:
4890:
4888:
4885:
4882:
4881:
4879:
4877:
4873:
4869:
4866:
4859:
4854:
4852:
4847:
4845:
4840:
4839:
4836:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4804:
4801:
4800:
4796:
4792:
4788:
4787:
4783:
4781:
4778:
4776:
4772:
4769:
4768:
4766:
4762:
4752:
4749:
4747:
4744:
4742:
4739:
4738:
4736:
4734:
4730:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4662:
4661:
4659:
4655:
4649:
4646:
4644:
4641:
4639:
4636:
4635:
4633:
4631:
4630:Protocadherin
4627:
4620:
4616:
4612:
4608:
4605:
4602:
4598:
4594:
4590:
4586:
4583:
4582:
4580:
4578:
4574:
4568:
4565:
4563:
4560:
4558:
4555:
4554:
4552:
4548:
4545:
4543:
4539:
4536:
4534:
4530:
4519:
4515:
4511:
4508:
4505:
4501:
4497:
4494:
4491:
4487:
4483:
4480:
4477:
4473:
4469:
4466:
4463:
4459:
4455:
4452:
4451:
4449:
4447:
4443:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4406:
4405:
4402:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4379:
4378:
4375:
4373:
4370:
4368:
4365:
4362:
4358:
4354:
4351:
4348:
4344:
4341:
4340:
4338:
4336:
4332:
4329:
4327:
4323:
4319:
4315:
4308:
4303:
4301:
4296:
4294:
4289:
4288:
4285:
4275:
4274:
4267:
4257:
4254:
4252:
4249:
4248:
4246:
4242:
4236:
4233:
4231:
4228:
4224:
4220:
4217:
4216:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4196:
4194:
4190:
4182:
4178:
4175:
4174:
4173:
4170:
4166:
4162:
4159:
4158:
4157:
4154:
4150:
4146:
4143:
4142:
4141:
4138:
4137:
4135:
4131:
4125:
4122:
4120:
4117:
4115:
4112:
4111:
4109:
4105:
4097:
4093:
4090:
4089:
4088:
4085:
4084:
4082:
4078:
4070:
4066:
4063:
4062:
4061:
4058:
4056:
4053:
4052:
4050:
4046:
4043:
4039:
4033:
4030:
4028:
4025:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3994:
3992:
3988:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3898:
3896:
3892:
3888:
3881:
3876:
3874:
3869:
3867:
3862:
3861:
3858:
3851:
3847:
3844:
3841:
3837:
3834:
3833:
3832:
3830:
3825:
3808:
3804:
3799:
3794:
3790:
3786:
3785:Endocrinology
3782:
3775:
3767:
3763:
3758:
3753:
3749:
3745:
3742:(4): 767–75.
3741:
3737:
3733:
3726:
3724:
3715:
3711:
3707:
3703:
3699:
3695:
3692:(4): 912–24.
3691:
3687:
3680:
3678:
3676:
3667:
3663:
3659:
3655:
3651:
3647:
3640:
3632:
3628:
3624:
3620:
3616:
3612:
3608:
3604:
3600:
3593:
3585:
3581:
3576:
3571:
3567:
3563:
3559:
3555:
3551:
3547:
3543:
3536:
3528:
3522:
3517:
3516:
3507:
3505:
3503:
3501:
3499:
3497:
3495:
3493:
3491:
3489:
3487:
3485:
3483:
3474:
3470:
3465:
3460:
3456:
3452:
3448:
3444:
3440:
3433:
3431:
3429:
3420:
3416:
3411:
3406:
3402:
3398:
3394:
3390:
3386:
3379:
3371:
3365:
3361:
3354:
3352:
3350:
3341:
3337:
3333:
3329:
3326:(2): 139–51.
3325:
3321:
3314:
3306:
3302:
3298:
3294:
3290:
3286:
3278:
3270:
3266:
3261:
3256:
3252:
3248:
3244:
3240:
3236:
3229:
3221:
3217:
3212:
3207:
3203:
3199:
3195:
3188:
3180:
3176:
3169:
3161:
3157:
3153:
3149:
3145:
3141:
3138:(9): 909–15.
3137:
3133:
3125:
3117:
3113:
3108:
3103:
3098:
3093:
3089:
3085:
3082:(8): e12043.
3081:
3077:
3073:
3069:
3062:
3054:
3050:
3045:
3040:
3036:
3032:
3028:
3024:
3020:
3013:
3005:
3001:
2996:
2991:
2986:
2981:
2977:
2973:
2969:
2962:
2954:
2950:
2946:
2942:
2938:
2934:
2927:
2919:
2915:
2910:
2905:
2900:
2895:
2891:
2887:
2883:
2876:
2868:
2864:
2860:
2856:
2852:
2848:
2841:
2833:
2829:
2824:
2819:
2815:
2811:
2807:
2803:
2799:
2792:
2784:
2780:
2775:
2770:
2766:
2762:
2758:
2751:
2743:
2739:
2735:
2731:
2727:
2723:
2716:
2708:
2704:
2700:
2696:
2689:
2681:
2677:
2673:
2669:
2664:
2659:
2656:(6): 673–87.
2655:
2651:
2647:
2640:
2632:
2628:
2623:
2618:
2614:
2610:
2606:
2602:
2598:
2591:
2583:
2579:
2575:
2571:
2568:(4): 311–39.
2567:
2563:
2556:
2548:
2544:
2537:
2529:
2525:
2521:
2517:
2513:
2509:
2502:
2494:
2490:
2486:
2482:
2477:
2472:
2469:(6): 673–87.
2468:
2464:
2460:
2453:
2451:
2442:
2438:
2434:
2430:
2426:
2422:
2415:
2407:
2403:
2398:
2393:
2389:
2385:
2381:
2377:
2373:
2369:
2365:
2358:
2356:
2351:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2321:
2315:
2307:
2304:
2301:
2298:
2296:
2294:
2284:
2283:
2279:
2275:
2272:
2269:
2267:
2265:
2264:
2253:
2252:
2248:
2244:
2241:
2238:
2236:
2234:
2233:
2222:
2221:
2217:
2214:
2211:
2209:
2207:
2206:
2195:
2194:
2191:
2187:
2183:
2179:
2175:
2172:
2169:
2166:
2164:
2163:
2152:
2151:
2148:, fibrinogen
2147:
2143:
2140:
2137:
2135:
2133:
2132:
2121:
2120:
2116:
2114:
2111:
2108:
2106:
2105:
2094:
2093:
2089:
2086:
2084:
2080:
2077:
2074:
2072:
2071:
2060:
2059:
2056:
2052:
2049:
2047:
2046:T-lymphocytes
2044:
2041:
2039:
2038:
2027:
2026:
2022:
2019:
2017:
2015:
2014:
2003:
2002:
1998:
1995:
1992:
1990:
1989:
1978:
1977:
1974:
1970:
1967:
1964:
1962:
1961:
1950:
1949:
1945:
1942:
1939:
1937:
1936:
1925:
1924:
1921:
1917:
1914:
1911:
1910:Hematopoietic
1908:
1905:
1903:
1902:
1891:
1890:
1886:
1883:
1880:
1878:
1868:
1867:
1863:
1860:
1857:
1855:
1845:
1844:
1841:
1837:
1834:
1831:
1828:
1826:
1816:
1815:
1811:
1808:
1805:
1802:
1801:
1798:
1790:
1788:
1784:
1780:
1776:
1762:
1758:
1752:
1749:
1747:
1744:
1742:cell survival
1741:
1739:
1738:cell division
1736:
1734:
1731:
1730:
1729:
1726:
1722:
1713:
1711:
1707:
1702:
1698:
1693:
1691:
1685:
1683:
1679:
1675:
1672:such as FAK (
1671:
1667:
1663:
1659:
1655:
1651:
1650:cell adhesion
1647:
1643:
1637:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1593:
1591:
1587:
1582:
1579:
1575:
1571:
1567:
1563:
1552:
1550:
1546:
1542:
1538:
1527:
1524:
1518:
1515:
1509:
1507:
1502:
1497:
1494:
1490:
1486:
1475:
1473:
1468:
1463:
1461:
1456:
1452:
1448:
1444:
1439:
1437:
1433:
1429:
1426:
1422:
1418:
1414:
1409:
1407:
1403:
1399:
1395:
1390:
1389:cell membrane
1385:
1383:
1374:
1372:
1369:
1367:
1366:
1362:
1361:
1358:
1356:
1353:
1351:
1350:
1346:
1345:
1342:
1340:
1337:
1335:
1334:
1330:
1329:
1325:
1323:
1320:
1318:
1317:
1313:
1312:
1309:
1307:
1304:
1302:
1301:
1297:
1296:
1293:GP3A, GPIIIa
1292:
1290:
1287:
1285:
1284:
1280:
1279:
1275:
1273:
1270:
1268:
1267:
1263:
1262:
1258:
1256:
1253:
1251:
1250:
1246:
1245:
1241:
1238:
1235:
1234:
1221:
1219:
1216:
1214:
1213:
1209:
1208:
1204:
1202:
1199:
1197:
1196:
1192:
1191:
1187:
1185:
1182:
1180:
1179:
1175:
1174:
1170:
1168:
1165:
1163:
1162:
1158:
1157:
1153:
1151:
1148:
1146:
1145:
1141:
1140:
1136:
1134:
1131:
1129:
1128:
1124:
1123:
1119:
1117:
1114:
1112:
1111:
1107:
1106:
1102:
1100:
1097:
1095:
1094:
1090:
1089:
1085:
1083:
1080:
1078:
1077:
1073:
1072:
1068:
1066:
1063:
1061:
1060:
1056:
1055:
1052:
1050:
1047:
1045:
1044:
1040:
1039:
1035:
1033:
1030:
1028:
1027:
1023:
1022:
1018:
1016:
1013:
1011:
1010:
1006:
1005:
1001:
999:
996:
994:
993:
989:
988:
984:
982:
979:
977:
976:
972:
971:
967:
965:
962:
960:
959:
955:
954:
950:
948:
945:
943:
942:
938:
937:
933:
931:
928:
926:
925:
921:
920:
916:
913:
910:
909:
900:
898:
894:
893:
888:
887:
882:
878:
874:
864:
862:
858:
854:
850:
846:
842:
838:
834:
831:
827:
822:
820:
815:
813:
809:
805:
801:
797:
793:
789:
785:
781:
767:
764:
762:
758:
755:
751:
747:
744:
742:
738:
734:
730:
727:
724:
720:
715:
711:
708:
704:
700:
697:
695:
691:
688:
685:
683:
679:
676:
673:
671:
667:
663:
659:
654:
647:
642:
637:
624:
618:
612:
606:
600:
594:
588:
582:
576:
570:
564:
558:
552:
546:
540:
536:
534:
530:
527:
524:
522:
518:
515:
511:
507:
504:
502:
498:
494:
490:
487:
484:
480:
475:
471:
468:
464:
460:
457:
455:
451:
448:
445:
443:
439:
436:
433:
431:
427:
424:
421:
419:
415:
412:
409:
407:
403:
400:Integrin_beta
399:
395:
390:
386:
381:
376:
365:
362:
360:
356:
353:
349:
345:
342:
340:
336:
332:
328:
325:
322:
318:
313:
309:
306:
302:
298:
295:
293:
289:
286:
283:
281:
277:
274:
271:
269:
265:
262:
259:
257:
253:
249:
245:
240:
233:
228:
223:
212:
209:
207:
203:
200:
196:
192:
189:
187:
183:
179:
175:
172:
169:
165:
160:
156:
153:
150:
148:
144:
141:
138:
136:
132:
129:
126:
124:
120:
117:
113:
109:
106:
104:
100:
97:
94:
92:
88:
85:
82:
79:
75:
72:
69:
67:
63:
59:
55:
50:
43:
38:
33:
19:
8159:Gap junction
7994:Ca signaling
7957:Cell surface
7766:Cerebrolysin
7762:
7736:Pleiotrophin
7692:Interleukins
7605:
7586:
7556:
7475:Fruquintinib
7465:Cabozantinib
7446:
7436:
7394:
7358:Lestaurtinib
7309:
7289:
7257:Lestaurtinib
7208:
7198:
7179:Antagonists:
7178:
7112:Deoxygedunin
7067:3,7,8,2'-THF
7058:
7037:
7028:Against NGF:
7027:
7024:
6980:Against NGF:
6979:
6972:
6969:
6932:Lestaurtinib
6883:
6873:
6867:Testosterone
6849:Antagonists:
6848:
6798:
6698:
6683:
6658:
6639:
6629:
6608:
6598:
6577:
6567:
6546:
6531:
6491:
6406:
6374:
6353:
6344:Against NGF:
6343:
6340:
6296:Against NGF:
6295:
6292:
6286:Testosterone
6268:Antagonists:
6267:
6217:
6187:
6148:
6123:
6112:
6089:Teprotumumab
6050:
6020:
5979:
5928:Ficlatuzumab
5923:Emibetuzumab
5919:
5873:JNJ-38877605
5843:Cabozantinib
5814:
5804:
5793:Fosgonimeton
5788:
5763:
5705:
5683:
5624:
5607:Infigratinib
5603:
5588:
5491:
5408:
5342:Betacellulin
5338:
5321:Seribantumab
5307:
5284:
5243:
5208:
5202:Unknown/none
5201:
5197:
5131:
5056:
5015:Betacellulin
5010:Amphiregulin
5005:
4997:(ErbB1/HER1)
4961:
4933:
4913:
4899:Antagonists:
4898:
4883:
4876:Angiopoietin
4785:
4784:
4445:
4270:
3886:
3821:
3788:
3784:
3774:
3739:
3735:
3689:
3685:
3652:(1): 61–73.
3649:
3645:
3639:
3606:
3602:
3592:
3549:
3545:
3535:
3514:
3446:
3442:
3392:
3388:
3378:
3359:
3323:
3319:
3313:
3288:
3284:
3277:
3242:
3238:
3228:
3201:
3197:
3187:
3168:
3135:
3131:
3124:
3079:
3075:
3061:
3026:
3022:
3012:
2975:
2971:
2961:
2939:(5): 681–9.
2936:
2932:
2926:
2889:
2885:
2875:
2850:
2846:
2840:
2805:
2801:
2791:
2764:
2760:
2750:
2725:
2721:
2715:
2701:(6): 741–5.
2698:
2694:
2688:
2653:
2649:
2639:
2604:
2600:
2590:
2565:
2561:
2555:
2546:
2536:
2511:
2507:
2501:
2466:
2462:
2424:
2420:
2414:
2371:
2367:
2341:(EPS or XPS)
2312:
2285:
2254:
2223:
2196:
2153:
2122:
2095:
2061:
2028:
2004:
1979:
1951:
1926:
1892:
1869:
1846:
1817:
1809:Distribution
1796:
1772:
1755:
1727:
1723:
1719:
1694:
1686:
1664:, and alpha-
1638:
1606:cytoskeleton
1599:
1583:
1558:
1533:
1519:
1514:orthogonally
1510:
1498:
1485:glycosylated
1481:
1464:
1459:
1440:
1410:
1386:
1382:RNA splicing
1379:
1363:
1347:
1331:
1314:
1298:
1281:
1264:
1247:
1210:
1193:
1176:
1159:
1142:
1125:
1108:
1091:
1074:
1057:
1041:
1024:
1007:
990:
973:
956:
939:
922:
890:
884:
873:heterodimers
870:
823:
816:
803:
800:cytoskeleton
779:
778:
8070:By distance
8008:Assistants:
7967:Co-receptor
7726:Oncomodulin
7590:Aflibercept
7580:Ranibizumab
7575:Ramucirumab
7565:Bevacizumab
7557:Antibodies:
7515:Regorafenib
7455:Altiratinib
7368:ONO-5390556
7338:Entrectinib
7313:Altiratinib
7267:ONO-5390556
7237:Entrectinib
7212:Altiratinib
6998:Frunevetmab
6970:Antibodies:
6947:ONO-5390556
6912:Entrectinib
6887:Altiratinib
6842:Tavilermide
6737:Quizartinib
6676:SCF (c-Kit)
6500:Ramucirumab
6492:Antibodies:
6465:Quizartinib
6415:Avapritinib
6378:Becaplermin
6314:Frunevetmab
6293:Antibodies:
6196:Trofinetide
6127:Dusigitumab
6124:Antibodies:
6079:Robatumumab
6069:Figitumumab
6064:Dalotuzumab
6059:Cixutumumab
6051:Antibodies:
5943:Rilotumumab
5938:Onartuzumab
5933:Flanvotumab
5920:Antibodies:
5888:PF-04217903
5818:Altiratinib
5781:HGF (c-Met)
5684:Antibodies:
5589:Antibodies:
5311:Duligotumab
5308:Antibodies:
5222:Trastuzumab
5212:Ertumaxomab
5209:Antibodies:
5180:Zalutumumab
5175:Panitumumab
5170:Nimotuzumab
5165:Necitumumab
5155:Imgatuzumab
5132:Antibodies:
5115:Osimertinib
5080:Dacomitinib
4975:Dapiclermin
4934:Antibodies:
4917:Altiratinib
4607:Desmocollin
2853:(1): 3–10.
2543:"Integrins"
2329:Disintegrin
2274:fibronectin
2243:fibronectin
2216:vitronectin
2178:osteopontin
2174:vitronectin
2146:osteopontin
2142:vitronectin
2079:Neutrophils
1973:proteinases
1916:Fibronectin
1783:growth cone
1733:cell growth
1706:endocytosis
1622:vitronectin
1618:fibronectin
1578:polio virus
1506:cilengitide
1188:VNRA, MSK8
897:cytoplasmic
853:vitronectin
849:fibronectin
812:coagulation
656:Identifiers
392:Identifiers
242:Identifiers
135:OPM protein
52:Identifiers
8174:Categories
8137:Pheromones
8077:Juxtacrine
7545:Vandetanib
7510:Rebastinib
7505:Pegaptanib
7495:Nintedanib
7485:Lenvatinib
7450:Agerafenib
7403:Ripretinib
7328:CH-7057288
7227:CH-7057288
7092:7,8,3'-THF
7087:7,8,2'-THF
7013:Ranevetmab
7003:Fulranumab
6957:Rebastinib
6902:CH-7057288
6817:Cenegermin
6702:Agerafenib
6662:Agerafenib
6643:Vandetanib
6612:Vandetanib
6581:Vandetanib
6550:Vandetanib
6495:Olaratumab
6470:Ripretinib
6450:Nintedanib
6435:Lenvatinib
6425:Crenolanib
6410:Agerafenib
6329:Ranevetmab
6319:Fulranumab
6236:Cenegermin
6210:LNGF (p75)
6132:Xentuzumab
6094:Xentuzumab
6039:NVP-AEW541
6034:NVP-ADW742
6029:Linsitinib
6024:BMS-754807
6009:Mecasermin
5908:Tivantinib
5898:PHA-665752
5893:PF-2341066
5863:Golvatinib
5853:Crizotinib
5848:Capmatinib
5838:BMS-777607
5833:Amuvatinib
5709:Ersofermin
5672:Sprifermin
5628:Ersofermin
5577:Sprifermin
5567:Repifermin
5562:Palifermin
5495:Ersofermin
5474:Velafermin
5459:Repifermin
5412:Ersofermin
5331:ErbB4/HER4
5316:Patritumab
5277:ErbB3/HER3
5257:Mubritinib
5217:Pertuzumab
5190:ErbB2/HER2
5120:Vandetanib
5075:Canertinib
5070:Brigatinib
5065:Agerafenib
5045:Nepidermin
5040:Murodermin
5030:Epiregulin
4985:EGF (ErbB)
4943:Nesvacumab
4937:Evinacumab
4927:Rebastinib
4868:modulators
4780:L-selectin
4751:P-selectin
4746:L-selectin
4741:E-selectin
4664:T-cadherin
4585:Desmoglein
4577:Desmosomal
3842:animation.
2978:: 852878.
2346:References
2334:Exopolymer
2300:Epithelial
2075:Mac-1, CR3
1996:widespread
1968:widespread
1887:Laminin-5
1678:Src kinase
1586:GpIIb/IIIa
1570:hantavirus
1562:adenovirus
1530:Activation
1523:antibodies
1443:N-terminal
886:Drosophila
814:factors).
796:cell cycle
729:structures
489:structures
327:structures
174:structures
147:Membranome
8180:Integrins
8091:Endocrine
8086:Paracrine
8082:Autocrine
7949:Receptors
7929:Cytokines
7570:Icrucumab
7550:WHI-P 154
7540:Tivozanib
7535:Toceranib
7530:Sunitinib
7525:Sorafenib
7520:Semaxanib
7500:Pazopanib
7490:Motesanib
7480:Lapatinib
7470:Cediranib
7408:Telbermin
7395:Agonists:
7343:GZ-389988
7323:CE-245677
7290:Agonists:
7242:GZ-389988
7222:CE-245677
7122:Diosmetin
7059:Agonists:
7025:Aptamers:
7018:Tanezumab
6993:Fasinumab
6937:Milciclib
6917:GZ-389988
6897:CE-245677
6799:Agonists:
6752:Toceranib
6747:Sunitinib
6742:Sorafenib
6732:Pazopanib
6727:Nilotinib
6722:Masitinib
6712:Dasatinib
6684:Agonists:
6630:Agonists:
6599:Agonists:
6568:Agonists:
6540:Liatermin
6532:Agonists:
6515:RET (GFL)
6505:Tovetumab
6485:Toceranib
6480:Sorafenib
6475:Sunitinib
6460:Radotinib
6455:Pazopanib
6445:Motesanib
6440:Masitinib
6375:Agonists:
6341:Aptamers:
6334:Tanezumab
6309:Fasinumab
6218:Agonists:
6074:Ganitumab
5994:IGF-1 LR3
5913:Volitinib
5868:INCB28060
5858:Foretinib
5764:Agonists:
5748:Trafermin
5706:Agonists:
5687:Burosumab
5677:Trafermin
5625:Agonists:
5592:Aprutumab
5582:Trafermin
5544:10 (KGF2)
5492:Agonists:
5469:Trafermin
5449:10 (KGF2)
5409:Agonists:
5339:Agonists:
5285:Agonists:
5267:Tucatinib
5262:Neratinib
5252:Lapatinib
5160:Matuzumab
5150:Futuximab
5135:Cetuximab
5125:WHI-P 154
5110:Neratinib
5105:Lapatinib
5095:Grandinin
5090:Gefitinib
5085:Erlotinib
4962:Agonists:
4922:CE-245677
4884:Agonists:
4733:Selectins
4550:Classical
4542:Cadherins
4446:Integrins
4377:L1 family
4271:see also
3887:Integrins
3846:Integrins
3829:Integrins
3623:0028-0836
3566:1550-6606
3068:Arruda EM
2186:thyroxine
2113:Platelets
2083:monocytes
2023:laminins
1999:laminins
1946:MAD-CAM1
1836:Collagens
1701:substrate
1590:platelets
1566:echovirus
1549:Kindlin-2
1545:Kindlin-1
1478:Structure
1455:cell-cell
1451:collagens
1398:N-termini
1326:FLJ26658
1242:synonyms
1120:FLJ39841
1103:HsT18964
1036:FLJ25220
917:synonyms
899:domains.
867:Structure
841:syndecans
837:selectins
826:cadherins
808:platelets
806:. signal
780:Integrins
687:IPR014836
620:,
614:,
608:,
602:,
596:,
590:,
584:,
578:,
572:,
566:,
560:,
554:,
548:,
542:,
447:PDOC00216
423:IPR002369
285:PDOC00215
273:IPR000413
96:IPR013649
18:Integrins
7911:Hormones
7861:JAK-STAT
7849:MAPK/ERK
7844:TGF beta
7752:instead)
7741:Renalase
7702:instead)
7673:instead)
7620:instead)
7460:Axitinib
7429:D (FIGF)
7373:PLX-7486
7363:ONO-4474
7318:AZD-6918
7272:PLX-7486
7262:ONO-4474
7217:AZD-6918
7199:Ligands:
7117:Deprenyl
7077:7,3'-DHF
7008:MEDI-578
6988:ASP-6294
6952:PLX-7486
6942:ONO-4474
6892:AZD-6918
6852:ALE-0540
6773:instead.
6717:Imatinib
6707:Axitinib
6687:Ancestim
6652:Unsorted
6430:Imatinib
6420:Axitinib
6324:MEDI-578
6304:ASP-6294
6271:ALE-0540
6113:Agonists
6054:AVE-1642
5980:Agonists
5903:SU-11274
5789:Agonists
5767:FGF15/19
5757:Unsorted
5722:2 (bFGF)
5641:2 (bFGF)
5508:2 (bFGF)
5425:2 (bFGF)
5247:Afatinib
5198:Agonists
5100:Icotinib
5060:Afatinib
5006:Agonists
4786:integrin
4335:IgSF CAM
3807:15802494
3766:10037797
3714:24240459
3706:17910028
3584:18768861
3473:29446228
3419:23644530
3340:21307119
3305:16061650
3269:30602723
3220:26583903
3179:Archived
3160:20775305
3152:20694000
3116:20805876
3076:PLOS ONE
3053:16581764
3004:35372360
2918:19240021
2832:20308986
2783:10497155
2742:15157154
2707:12901235
2680:30326350
2672:12297042
2582:10961914
2528:10446041
2493:30326350
2485:12297042
2441:10446050
2406:11546839
2318:See also
1840:laminins
1812:Ligands
1806:Synonyms
1662:paxillin
1658:vinculin
1634:ontogeny
1626:collagen
1555:Function
1425:divalent
1421:cysteine
1392:23
1239:protein
1230:(mammal)
1137:HUMINAE
914:protein
905:(mammal)
881:isoforms
877:subunits
857:collagen
746:RCSB PDB
682:InterPro
506:RCSB PDB
418:InterPro
344:RCSB PDB
268:InterPro
191:RCSB PDB
91:InterPro
8042:General
7866:Akt/PKB
7629:Ephrins
7333:DS-6051
7232:DS-6051
7137:LM22A-4
7127:DMAQ-B1
7082:7,8-DHF
7062:3,7-DHF
7031:RBM-004
6976:GBR-900
6907:DS-6051
6877:VM-902A
6347:RBM-004
6044:OSl-906
6004:Insulin
5883:MK-2461
5828:AMG-458
4965:Axokine
3838:– PMAP
3757:2132927
3666:9150551
3631:8684468
3575:2778276
3464:6055631
3410:4040366
3260:6597357
3107:2923603
3084:Bibcode
3044:1446957
2995:8971850
2953:8573343
2909:2670154
2867:8031639
2823:3929966
2631:2977331
2508:Science
2421:Science
2397:2885948
2376:Bibcode
2368:Science
2324:D-dimer
2306:Laminin
1943:T cells
1690:Y-27632
1670:kinases
1666:actinin
1630:laminin
1614:ligands
1436:ligands
1432:cations
1428:cations
1406:lobster
1086:PRO827
861:laminin
845:Ligands
675:PF08725
626:
442:PROSITE
435:SM00187
411:PF00362
280:PROSITE
261:PF00357
71:PF08441
7895:Agents
7599:Others
7293:BNN-20
7182:ANA-12
7107:BNN-20
6827:DHEA-S
6812:BNN-27
6807:BNN-20
6246:DHEA-S
6231:BNN-27
6226:BNN-20
6142:Others
5347:Epigen
5025:Epigen
4648:PCDH19
4643:PCDH15
4514:ITGA2B
4404:Nectin
4382:L1-CAM
4372:PE-CAM
4367:VCAM-1
4065:ITGA2B
4041:Dimers
3852:(MeSH)
3805:
3764:
3754:
3712:
3704:
3664:
3629:
3621:
3603:Nature
3582:
3572:
3564:
3523:
3471:
3461:
3417:
3407:
3366:
3338:
3303:
3267:
3257:
3218:
3158:
3150:
3114:
3104:
3051:
3041:
3002:
2992:
2951:
2916:
2906:
2865:
2830:
2820:
2781:
2740:
2705:
2678:
2670:
2629:
2622:455118
2619:
2580:
2526:
2491:
2483:
2439:
2404:
2394:
2302:cells
2190:TETRAC
2055:ICAM-2
2051:ICAM-1
1940:LPAM-1
1920:VCAM-1
1676:) and
1628:, and
1205:GPIIb
1195:ITGA2B
1171:MAC-1
1154:LFA1A
1099:ITGA11
1093:ITGA11
1082:ITGA10
1076:ITGA10
903:alpha
828:, the
761:PDBsum
735:
725:
707:SUPFAM
661:Symbol
521:PDBsum
495:
485:
467:SUPFAM
397:Symbol
359:PDBsum
333:
323:
305:SUPFAM
247:Symbol
206:PDBsum
180:
170:
116:SUPFAM
84:CL0159
57:Symbol
8057:TFIIH
8052:TFIID
7876:Hippo
7856:Notch
7748:(see
7698:(see
7669:(see
7616:(see
7348:K252a
7247:K252a
6922:K252a
6862:FX007
6622:GFRα4
6591:GFRα3
6560:GFRα2
6524:GFRα1
6152:IGFBP
6105:IGF-2
6084:R1507
5972:IGF-1
5878:K252a
5698:FGFR4
5617:FGFR3
5484:FGFR2
5401:FGFR1
4823:EpCAM
4818:CD146
4795:LFA-1
4791:VLA-4
4764:Other
4719:CDH10
4709:CDH17
4704:CDH16
4699:CDH15
4694:CDH12
4689:CDH11
4638:PCDH1
4518:ITGB3
4500:CD49d
4496:VLA-4
4486:CD11b
4472:CD11c
4458:CD11a
4454:LFA-1
4434:CD155
4429:CADM3
4424:CADM1
4419:PVRL3
4414:PVRL2
4409:PVRL1
4392:NFASC
4387:NRCAM
4343:N-CAM
4219:CD49d
4214:VLA-4
4177:CD11c
4161:CD11b
4145:CD11a
4140:LFA-1
4092:CD11b
4069:ITGB3
3894:Alpha
3710:S2CID
3156:S2CID
2676:S2CID
2489:S2CID
2182:Cyr61
2088:Serum
2042:LFA-1
1912:cells
1906:VLA-4
1881:VLA-3
1858:VLA-2
1829:VLA-1
1654:talin
1501:X-ray
1371:ITGB8
1365:ITGB8
1355:ITGB7
1349:ITGB7
1339:ITGB6
1333:ITGB6
1322:ITGB5
1316:ITGB5
1306:CD104
1300:ITGB4
1283:ITGB3
1266:ITGB2
1249:ITGB1
1236:gene
1228:beta
1218:CD11c
1212:ITGAX
1178:ITGAV
1167:CD11b
1161:ITGAM
1150:CD11a
1144:ITGAL
1133:CD103
1127:ITGAE
1116:CD11D
1110:ITGAD
1065:ITGA9
1059:ITGA9
1049:ITGA8
1043:ITGA8
1032:ITGA7
1026:ITGA7
1019:VLA6
1015:CD49f
1009:ITGA6
1002:VLA5
998:CD49e
992:ITGA5
985:VLA4
981:CD49d
975:ITGA4
968:VLA3
964:CD49c
958:ITGA3
951:VLA2
947:CD49b
941:ITGA2
934:VLA1
930:CD49a
924:ITGA1
911:gene
703:SCOPe
694:SCOP2
463:SCOPe
454:SCOP2
430:SMART
301:SCOPe
292:SCOP2
112:SCOPe
103:SCOP2
7827:GPCR
7750:here
7700:here
7671:here
7618:here
7413:VEGF
7387:VEGF
7303:NT-3
7298:DHEA
7282:TrkC
7202:DHEA
7172:TDP6
7152:NT-4
7147:NT-3
7132:HIOC
7102:BDNF
7051:TrkB
6822:DHEA
6791:TrkA
6771:here
6769:See
6762:TGFβ
6367:PDGF
6261:NT-4
6256:NT-3
6241:DHEA
6221:BDNF
4970:CNTF
4954:CNTF
4813:CD44
4808:CD24
4775:CD44
4714:CDH9
4684:CDH8
4679:CDH6
4674:CDH5
4669:CDH4
4619:DSC3
4615:DSC2
4611:DSC1
4601:DSG4
4597:DSG3
4593:DSG2
4589:DSG1
4567:CDH3
4562:CDH2
4557:CDH1
4504:CD29
4490:CD18
4476:CD18
4462:CD18
4397:CHL1
4353:ICAM
4223:CD29
4181:CD18
4165:CD18
4149:CD18
4096:CD18
3990:Beta
3803:PMID
3762:PMID
3702:PMID
3662:PMID
3627:PMID
3619:ISSN
3580:PMID
3562:ISSN
3521:ISBN
3469:PMID
3415:PMID
3364:ISBN
3336:PMID
3301:PMID
3265:PMID
3216:PMID
3148:PMID
3112:PMID
3049:PMID
3000:PMID
2949:PMID
2914:PMID
2863:PMID
2828:PMID
2779:PMID
2738:PMID
2703:PMID
2668:PMID
2650:Cell
2627:PMID
2578:PMID
2524:PMID
2481:PMID
2463:Cell
2437:PMID
2402:PMID
2280:1+3
2278:TGFβ
2249:1+3
2247:TGFβ
2081:and
1884:Many
1861:Many
1832:Many
1803:Name
1642:VEGF
1547:and
1499:The
1460:this
1411:The
1289:CD61
1272:CD18
1255:CD29
1201:CD41
1184:CD51
1069:RLC
859:and
839:and
782:are
754:PDBj
750:PDBe
733:ECOD
723:Pfam
699:1m8O
670:Pfam
623:1u8c
617:1tye
611:1ty7
605:1ty6
599:1ty5
593:1ty3
587:1txv
581:1s4x
575:1m8o
569:1m1x
563:1l5g
557:1l3y
551:1kuz
545:1kup
539:1jv2
514:PDBj
510:PDBe
493:ECOD
483:Pfam
459:1jv2
406:Pfam
352:PDBj
348:PDBe
331:ECOD
321:Pfam
297:1dpk
256:Pfam
199:PDBj
195:PDBe
178:ECOD
168:Pfam
140:2knc
108:1jv2
80:clan
78:Pfam
66:Pfam
7839:RTK
7834:Wnt
7167:R13
6837:NGF
6782:Trk
6251:NGF
5963:IGF
5823:AM7
5714:FGF
5633:FGF
5534:),
5532:KGF
5500:FGF
5417:FGF
5392:FGF
4994:EGF
3951:A11
3946:A10
3793:doi
3789:146
3752:PMC
3744:doi
3740:144
3694:doi
3690:102
3654:doi
3611:doi
3607:382
3570:PMC
3554:doi
3550:181
3459:PMC
3451:doi
3405:PMC
3397:doi
3328:doi
3324:209
3293:doi
3255:PMC
3247:doi
3206:doi
3140:doi
3102:PMC
3092:doi
3039:PMC
3031:doi
2990:PMC
2980:doi
2941:doi
2904:PMC
2894:doi
2890:284
2855:doi
2851:112
2818:PMC
2810:doi
2769:doi
2765:274
2730:doi
2658:doi
2654:110
2617:PMC
2609:doi
2570:doi
2516:doi
2512:285
2471:doi
2467:110
2429:doi
2425:285
2392:PMC
2384:doi
2372:294
2099:IIb
1682:CRK
1646:EGF
1537:ECM
1417:kDa
804:e.g
741:PDB
533:PDB
501:PDB
339:PDB
186:PDB
128:176
8176::
8084:/
7811:/
7661:B3
7659:,
7657:B2
7655:,
7653:B1
7651:,
7649:A5
7647:,
7645:A4
7643:,
7641:A3
7639:,
7637:A2
7635:,
7633:A1
7427:,
7423:,
7419:,
7162:R7
6978:;
6397:,
6393:,
6389:,
6178:,
6174:,
6170:,
6166:,
6162:,
6158:,
6115::
5982::
5791::
5742:19
5740:,
5736:,
5732:,
5728:,
5724:,
5720:,
5661:23
5659:,
5657:18
5655:,
5651:,
5647:,
5643:,
5639:,
5556:22
5554:,
5552:18
5550:,
5548:17
5546:,
5542:,
5538:,
5526:,
5522:,
5518:,
5514:,
5510:,
5506:,
5453:20
5451:,
5447:,
5443:,
5439:,
5435:,
5431:,
5427:,
5423:,
5375:,
5371:,
5367:,
5363:,
5298:,
5294:,
5200::
5008::
4793:,
4773::
4617:,
4613:,
4599:,
4595:,
4591:,
4359:,
4316::
4032:B8
4027:B7
4022:B6
4017:B5
4012:B4
4007:B3
4002:B2
3997:B1
3981:AX
3976:AV
3971:AM
3966:AL
3961:AE
3956:AD
3941:A9
3936:A8
3931:A7
3926:A6
3921:A5
3916:A4
3911:A3
3906:A2
3901:A1
3801:.
3787:.
3783:.
3760:.
3750:.
3738:.
3734:.
3722:^
3708:.
3700:.
3688:.
3674:^
3660:.
3650:34
3648:.
3625:.
3617:.
3605:.
3601:.
3578:.
3568:.
3560:.
3548:.
3544:.
3481:^
3467:.
3457:.
3447:93
3445:.
3441:.
3427:^
3413:.
3403:.
3393:73
3391:.
3387:.
3348:^
3334:.
3322:.
3299:.
3289:65
3287:.
3263:.
3253:.
3243:21
3241:.
3237:.
3214:.
3202:25
3200:.
3196:.
3154:.
3146:.
3136:12
3134:.
3110:.
3100:.
3090:.
3078:.
3074:.
3047:.
3037:.
3027:26
3025:.
3021:.
2998:.
2988:.
2976:10
2974:.
2970:.
2947:.
2935:.
2912:.
2902:.
2888:.
2884:.
2861:.
2849:.
2826:.
2816:.
2806:11
2804:.
2800:.
2777:.
2763:.
2759:.
2736:.
2726:32
2724:.
2697:.
2674:.
2666:.
2652:.
2648:.
2625:.
2615:.
2603:.
2599:.
2576:.
2566:28
2564:.
2545:.
2522:.
2510:.
2487:.
2479:.
2465:.
2461:.
2449:^
2435:.
2423:.
2400:.
2390:.
2382:.
2370:.
2366:.
2354:^
2276:;
2245:;
2188:,
2184:,
2180:,
2144:,
2053:,
1918:,
1838:,
1660:,
1656:,
1644:,
1636:.
1624:,
1620:,
1576:,
1572:,
1568:,
1564:,
1394:nm
863:.
855:,
851:,
835:,
752:;
748:;
731:/
705:/
701:/
512:;
508:;
491:/
465:/
461:/
350:;
346:;
329:/
303:/
299:/
197:;
193:;
176:/
152:13
114:/
110:/
7922:/
7918:/
7801:e
7794:t
7787:v
7694:/
7663:)
7631:(
7431:)
7425:C
7421:B
7417:A
7415:(
6964:)
6401:)
6399:D
6395:C
6391:B
6387:A
6385:(
6182:)
6180:7
6176:6
6172:5
6168:4
6164:3
6160:2
6156:1
6154:(
5744:)
5738:9
5734:8
5730:6
5726:4
5718:1
5716:(
5663:)
5653:9
5649:8
5645:4
5637:1
5635:(
5558:)
5540:9
5536:8
5530:(
5528:7
5524:6
5520:5
5516:4
5512:3
5504:1
5502:(
5455:)
5445:8
5441:6
5437:5
5433:4
5429:3
5421:1
5419:(
5379:)
5373:4
5369:3
5365:2
5361:1
5359:(
5302:)
5296:2
5292:1
5290:(
4857:e
4850:t
4843:v
4797:)
4789:(
4621:)
4609:(
4603:)
4587:(
4520:)
4516:+
4512:(
4506:)
4502:+
4498:(
4492:)
4488:+
4484:(
4478:)
4474:+
4470:(
4464:)
4460:+
4456:(
4363:)
4361:5
4357:1
4355:(
4349:)
4345:(
4306:e
4299:t
4292:v
4221:+
4179:+
4163:+
4147:+
4094:+
4067:+
3879:e
3872:t
3865:v
3809:.
3795::
3768:.
3746::
3716:.
3696::
3668:.
3656::
3633:.
3613::
3586:.
3556::
3529:.
3475:.
3453::
3421:.
3399::
3372:.
3342:.
3330::
3307:.
3295::
3271:.
3249::
3222:.
3208::
3162:.
3142::
3118:.
3094::
3086::
3080:5
3055:.
3033::
3006:.
2982::
2955:.
2943::
2937:7
2920:.
2896::
2869:.
2857::
2834:.
2812::
2785:.
2771::
2744:.
2732::
2709:.
2699:4
2682:.
2660::
2633:.
2611::
2605:7
2584:.
2572::
2530:.
2518::
2495:.
2473::
2443:.
2431::
2408:.
2386::
2378::
2292:4
2290:β
2288:6
2286:α
2262:8
2260:β
2258:V
2256:α
2231:6
2229:β
2227:V
2225:α
2204:5
2202:β
2200:V
2198:α
2161:3
2159:β
2157:V
2155:α
2130:1
2128:β
2126:V
2124:α
2103:3
2101:β
2097:α
2069:2
2067:β
2065:M
2063:α
2036:2
2034:β
2032:L
2030:α
2012:1
2010:β
2008:7
2006:α
1987:1
1985:β
1983:6
1981:α
1959:1
1957:β
1955:5
1953:α
1934:7
1932:β
1930:4
1928:α
1900:1
1898:β
1896:4
1894:α
1876:1
1874:β
1872:3
1870:α
1853:1
1851:β
1849:2
1847:α
1824:1
1822:β
1820:1
1818:α
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
