318:
295:
1578:
a C-terminal putative dibasic (Arg-Arg) cleavage motif. Preptin is present in islet beta-cells, undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. It has an anabolic impact on bone growth and exhibits osteogenic properties, increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. This activity resides within the first 16 amino acids of preptin. Genetic ablation of the preptin-coding region of Igf2 in female mice impairs pancreatic function.
217:
192:
2719:
583:
576:
569:
324:
223:
29:
1626:
induces a decrease in methylation level at IGF-2 demethylated region, and this might be among the mechanisms behind the association between intrauterine exposure to preeclampsia and high risk for metabolic diseases in the later life of the infants. In animals it has been shown that toxins such as PCB
1577:
Preptin, a 34-aa peptide hormone produced by the pancreas, kidneys, breast tissues, and salivary glands, is derived from proteolytic cleavage of IGF-2 proprotein. The sequence of preptin (amino acids 93-126 of canonical IGF-2 preproprotein) is flanked by an N-terminal arginine (Arg) cleavage site and
1544:
In the process of folliculogenesis, IGF-2 is created by thecal cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on granulosa cells in the ovary. IGF-2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting alongside
55:
1496:
region. The mechanism in which CTCF binds to these regions is currently unknown, but could include either a direct DNA-CTCF interaction or it could possibly be mediated by other proteins. In mammals (mice, humans, pigs), only the allele for insulin-like growth factor-2
1513:
The canonical isoform of IGF-2 preproprotein (180 amino acids) includes a signal peptide (amino acids 1-24) and a propeptide (amino acids 92-180). Proteolytic processing removes the signal peptide and the propeptide to generate the mature hormone (amino acids 25-91).
2287:
Höglund O, Sjölund C, Shokrai A, Bäcklin BM, Backhaus A, Wikström K, Granerus M, Engström W (June 1993). "The effects of polychlorinated biphenyls on growth factor expression and biological reproduction in the mink (Mustela vison)".
2122:
Amso Z, Kowalczyk R, Watson M, Park YF, Callon KE, Musson DS, Cornish J, Brimble M (21 Oct 2016). "Structure activity relationship study on the peptide hormone preptin, a novel bone-anabolic agent for the treatment of osteoporosis".
331:
230:
1552:
A study at the Mount Sinai School of
Medicine found that IGF-2 may be linked to memory and reproduction. A study at the European Neuroscience Institute-Goettingen (Germany) found that fear extinction-induced
1505:
promoter and enhancer. So does the father's allele, but in his case, the insulator has been methylated. CTCF can no longer bind to the insulator, and so the enhancer is now free to turn on the father's
1412:
believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on
2718:
2201:
Balduyck B, Lauwers P, Govaert K, Hendriks J, De
Maeseneer M, Van Schil P (Jul 2006). "Solitary fibrous tumor of the pleura with associated hypoglycemia: Doege-Potter syndrome: a case report".
2016:
Agis-Balboa RC, Arcos-Diaz D, Wittnam J, Govindarajan N, Blom K, Burkhardt S, Haladyniak U, Agbemenyah HY, Zovoilis A, Salinas-Riester G, Opitz L, Sananbenesi F, Fischer A (Oct 2011).
6278:
1501:) inherited from one's father is active; that inherited from the mother is not—a phenomenon called imprinting. The mechanism: the mother's allele has an insulator between the
6298:
6288:
4067:
4443:
1361:
1557:
signalling promotes the survival of 17- to 19-day-old newborn hippocampal neurons. This suggests that therapeutic strategies that enhance IGF-2 signalling and adult
1549:
secretion during the luteal phase of the menstrual cycle, together with luteinizing hormone (LH). Thus, IGF-2 acts as a co-hormone together with both FSH and LH.
2158:
Buckels EJ, Hsu H-L, Buchanan CM, Matthews BG (1 Dec 2022). "Genetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female mice".
6273:
7014:
4808:
1824:
961:
942:
153:
6043:
4118:
5982:
5159:
4351:
4060:
6942:
5084:
2067:"Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion"
6666:
6579:
6524:
6478:
6423:
6158:
6098:
5099:
5029:
4588:
4186:
4128:
1744:
1726:
6661:
6539:
6438:
6224:
6113:
5913:
5873:
5621:
5540:
5402:
5343:
5305:
5250:
5245:
5235:
5109:
5104:
5074:
5049:
5044:
5034:
4920:
4839:
4778:
4706:
4685:
4670:
4623:
4276:
6761:
6619:
6598:
6554:
6534:
6453:
6433:
6148:
6128:
6108:
5751:
5746:
5079:
4803:
4336:
4133:
3564:
3536:
3433:
1484:
imprinting control region (ICR) along with
Differentially-methylated Region-1 (DMR1) and Matrix Attachment Region −3 (MAR3). These three
7009:
6584:
6574:
6529:
6483:
6473:
6428:
6252:
6219:
6199:
6163:
6153:
6103:
6063:
5535:
5515:
5482:
5363:
5265:
5114:
4053:
1232:
6544:
6443:
6338:
6242:
6194:
6187:
6173:
6118:
6088:
5568:
5558:
5510:
5492:
5421:
5255:
5094:
5039:
1225:
6283:
5973:
2759:
2369:"Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding"
5578:
5295:
3392:
1622:. As IGF-2 promotes development of fetal pancreatic beta cells, it is believed to be related to some forms of diabetes mellitus.
1866:"Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells"
6383:
4563:
4246:
3113:
3108:
2984:
2410:"Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit"
2320:"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3"
6999:
6961:
6911:
6882:
6829:
5316:
5183:
3634:
2698:
1834:
1660:
1534:
1530:
1709:
1381:
6640:
6636:
6632:
6628:
4181:
4165:
3316:
3185:
3180:
3175:
52:
4909:
4828:
4695:
4612:
1688:
7019:
6624:
3277:
3249:
3167:
1946:
1665:
6313:
5432:
4992:
4603:
2787:
2727:: SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS
2608:
1959:
Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM (Jan 2011).
1923:
1595:
317:
4261:
4205:
4196:
3737:
1780:
Pham NV, Nguyen MT, Hu JF, Vu TH, Hoffman AR (Nov 1998). "Dissociation of IGF2 and H19 imprinting in human brain".
6835:
3311:
3073:
3002:
2525:"Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology"
2236:
He J, Zhang A, Fang M, Fang R, Ge J, Jiang Y, Zhang H, Han C, Ye X, Yu D, Huang H, Liu Y, Dong M (12 July 2013).
1713:
1692:
294:
6922:
6898:
6038:
5594:
5457:
3843:
3466:
3402:
3296:
3134:
2802:
1006:
1369:
6888:
3858:
3326:
3301:
2626:
Fowden AL, Sibley C, Reik W, Constancia M (2006). "Imprinted genes, placental development and fetal growth".
216:
191:
2451:"Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3"
1864:
Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A, Vigneri R (1999).
987:
6932:
5200:
3910:
3652:
3367:
3056:
2752:
1538:
133:
6303:
3397:
3377:
3190:
2952:
2666:
1640:
1619:
6917:
4743:
4023:
3905:
3046:
3029:
2994:
2831:
1365:
330:
229:
7004:
6825:
4028:
2691:
1628:
323:
222:
3586:
120:
5009:
4925:
4844:
4711:
4628:
3657:
3216:
2776:
2670:
1204:
1200:
1196:
1192:
1171:
1167:
1163:
1159:
1129:
1125:
1117:
1113:
1092:
1088:
1084:
1076:
141:
6609:
4356:
4231:
3886:
3195:
2979:
2745:
1607:
1533:
and to the short isoform of the insulin receptor (IR-A or exon 11-). IGF-2 may also bind to the
1208:
1155:
1121:
1080:
6893:
6509:
6413:
6033:
5452:
4438:
4076:
3732:
3709:
3461:
3242:
6967:
5164:
4448:
4087:
3478:
1603:
1430:
205:
3441:
1463:
6907:
6293:
5225:
5174:
2684:
1972:
1587:
1348:
161:
8:
6048:
5462:
4018:
3624:
3619:
3591:
3554:
3387:
3372:
3336:
3211:
2018:"A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories"
1976:
1850:
5726:
4079:
3359:
2647:
2349:
2301:
2264:
2237:
2183:
2104:
2091:
2066:
2042:
2017:
1993:
1960:
1805:
1610:
in which hypoglycemia is associated with the presence of one or more non-islet fibrous
1446:
1442:
165:
2600:
2540:
2507:
2336:
2319:
2238:"Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies"
1793:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
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786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
685:
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675:
659:
654:
649:
644:
639:
634:
629:
624:
6353:
3546:
3235:
2639:
2614:
2604:
2579:
2544:
2511:
2472:
2431:
2390:
2341:
2269:
2218:
2214:
2187:
2175:
2140:
2096:
2047:
1998:
1942:
1919:
1895:
1890:
1865:
1830:
1797:
1457:. However, in some human brain regions a loss of imprinting occurs resulting in both
1356:
113:
45:
4045:
2353:
2108:
1809:
1310:
6771:
5903:
3513:
3508:
2651:
2631:
2596:
2569:
2536:
2503:
2462:
2421:
2380:
2331:
2297:
2259:
2249:
2210:
2167:
2132:
2086:
2078:
2037:
2029:
1988:
1980:
1885:
1877:
1789:
1344:
410:
341:
285:
240:
145:
3838:
3471:
3266:
2966:
1545:
follicle stimulating hormone (FSH). After ovulation has occurred, IGF-2 promotes
1475:
1453:
is imprinted, with expression resulting favourably from the paternally inherited
1322:
385:
169:
2082:
1749:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1731:
National Center for
Biotechnology Information, U.S. National Library of Medicine
6957:
6878:
6820:
6514:
6363:
6358:
5472:
5467:
4113:
4103:
4098:
3990:
3959:
3931:
3876:
3488:
3419:
2318:
Storch S, Kübler B, Höning S, Ackmann M, Zapf J, Blum W, Braulke T (Dec 2001).
2171:
1615:
1541:), which acts as a signalling antagonist; that is, to prevent IGF-2 responses.
486:
3771:
6993:
6651:
6564:
6493:
6463:
6398:
6308:
6262:
6138:
6068:
6013:
6002:
5487:
5195:
4878:
4783:
4675:
4000:
3776:
2768:
2254:
1762:
1438:
611:
582:
575:
2558:"The insulin-like growth factor/insulin system in epithelial ovarian cancer"
2426:
2409:
2385:
2368:
546:
424:
6977:
6947:
6686:
6676:
6569:
6468:
6323:
6143:
6078:
5993:
5497:
5300:
5139:
5134:
5054:
5004:
4818:
4572:
4553:
4532:
4503:
4226:
4221:
3783:
3719:
3704:
3667:
3614:
3581:
3321:
3288:
2643:
2618:
2583:
2467:
2450:
2394:
2345:
2273:
2222:
2179:
2144:
2100:
2051:
2033:
2002:
1899:
1623:
1599:
1558:
1546:
1485:
1413:
568:
403:
182:
2548:
2515:
2476:
2435:
1881:
1829:(3rd ed.). Upper Saddle River, N.J.: Pearson Education. p. 533.
1801:
1272:
1267:
6937:
6903:
6801:
6791:
6786:
6776:
6726:
6549:
6448:
6209:
6123:
6053:
5948:
5711:
5676:
5626:
5589:
5525:
5407:
5338:
5290:
5280:
5275:
5270:
5154:
5149:
5144:
4522:
4433:
4423:
4391:
4386:
4381:
4376:
4366:
4326:
4291:
3967:
3944:
3446:
3349:
1648:
1051:
1032:
2494:
O'Dell SD, Day IN (Jul 1998). "Insulin-like growth factor II (IGF-II)".
2367:
Buckway CK, Wilson EM, Ahlsén M, Bang P, Oh Y, Rosenfeld RG (Oct 2001).
2015:
1984:
28:
6756:
6721:
6716:
6706:
6696:
6614:
6403:
6378:
6368:
6214:
6168:
6028:
5854:
5823:
5792:
5761:
5706:
5681:
5661:
5646:
5636:
5530:
5447:
5240:
5220:
5119:
5064:
5059:
4883:
4788:
4773:
4568:
4527:
4499:
4468:
4428:
4331:
4286:
4281:
4256:
4251:
4241:
4154:
4148:
4138:
3995:
3881:
3531:
3483:
3412:
3407:
3017:
3012:
3007:
2523:
Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D (Sep 1998).
2136:
1480:
302:
199:
149:
2635:
90:
86:
82:
78:
74:
6781:
6751:
6746:
6741:
6736:
6731:
6711:
6701:
6691:
6681:
6373:
6333:
6229:
6204:
5963:
5958:
5953:
5943:
5938:
5933:
5923:
5844:
5782:
5716:
5696:
5691:
5686:
5671:
5666:
5656:
5651:
5545:
5520:
5285:
5205:
5124:
5069:
4959:
4898:
4888:
4793:
4680:
4478:
4473:
4463:
4371:
4361:
4346:
4321:
4316:
4306:
4301:
4296:
3798:
3727:
3609:
3521:
3456:
3382:
3118:
2974:
1523:
906:
369:
356:
268:
255:
157:
2595:. International Review of Cytology. Vol. 243. pp. 215–85.
2524:
1961:"A critical role for IGF-II in memory consolidation and enhancement"
1618:. Loss of imprinting of IGF-2 is a common feature in tumors seen in
827:
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
124:, C11orf43, GRDF, IGF-II, PP9974, insulin like growth factor 2, SRS3
6952:
6671:
6328:
5928:
5918:
5898:
5641:
5631:
4978:
4458:
4401:
4311:
4271:
3949:
3848:
3830:
3788:
3766:
3689:
3681:
3662:
3644:
3573:
3451:
3344:
3306:
2928:
1317:
1256:
5833:
5802:
5771:
5735:
1958:
1416:. It is believed to be a major fetal growth factor in contrast to
6927:
6348:
5813:
5215:
4176:
3853:
3820:
3815:
3807:
3694:
3629:
3500:
3258:
3103:
3042:
2737:
2574:
2557:
1409:
1405:
1401:
1018:
973:
891:
887:
1522:
The major role of IGF-2 is as a growth promoting hormone during
137:
6840:
6504:
6393:
6318:
6023:
6018:
5442:
5437:
5391:
5387:
5383:
5379:
5375:
5371:
5367:
5019:
4558:
4236:
3977:
3939:
3758:
3699:
1644:
1554:
1454:
1376:
1240:
928:
767:
positive regulation of protein serine/threonine kinase activity
591:
2676:
2200:
2157:
6872:
6868:
6864:
6860:
6856:
6852:
6848:
6844:
6559:
6458:
6133:
6073:
5887:
5610:
5606:
5602:
5598:
5089:
4953:
4872:
4868:
4767:
4763:
4759:
4755:
4664:
4660:
4511:
4010:
3985:
3896:
3868:
3601:
3157:
3152:
3147:
3142:
3098:
3093:
3088:
3083:
2947:
2942:
2937:
2913:
2907:
2901:
2895:
2875:
2871:
2862:
2858:
2849:
2845:
1611:
1591:
1417:
2496:
2286:
1851:"Insulin-like growth factor II, UniProtKB P01344 IGF2_HUMAN"
1408:. The MeSH definition reads: "A well-characterized neutral
6343:
4949:
4945:
4941:
4937:
4933:
4929:
4864:
4860:
4856:
4852:
4848:
4751:
4747:
4739:
4735:
4731:
4727:
4723:
4719:
4715:
4656:
4652:
4648:
4644:
4640:
4636:
4632:
4584:
4580:
4576:
4542:
4507:
4488:
3227:
2867:
2854:
2841:
2819:
2815:
2811:
2806:
2798:
1566:
1562:
1489:
1471:
1434:
1338:
1305:
2625:
1863:
1287:
Insulin-like growth factor II E-peptide (somatomedians-A )
877:
positive regulation of glycogen (starch) synthase activity
2317:
852:
positive regulation of insulin receptor signaling pathway
847:
positive regulation of transcription by RNA polymerase II
782:
negative regulation of transcription by RNA polymerase II
1561:
might be suitable to treat diseases linked to excessive
857:
positive regulation of peptidyl-tyrosine phosphorylation
393:
2448:
2366:
2121:
1917:(1st ed.). San Diego: Academic Press. p. 222.
1492:
in a way that limits downstream enhancer access to the
6943:
Pituitary adenylate cyclase-activating peptide (PACAP)
2522:
2064:
1940:(1st ed.). San Diego: Academic Press. p. 22.
4075:
3276:
762:
positive regulation of activated T cell proliferation
558:
2373:
The
Journal of Clinical Endocrinology and Metabolism
1449:
is found at distal chromosome 7. In both organisms,
1420:(IGF-1), which is a major growth factor in adults."
842:
positive regulation of glycogen biosynthetic process
832:
positive regulation of multicellular organism growth
807:
positive regulation of cell population proliferation
702:
regulation of gene expression by genetic imprinting
521:
dentate gyrus of hippocampal formation granule cell
6889:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5747:Glial cell line-derived neurotrophic factor (GDNF)
5400:Cleavage products/derivatives with unknown target:
2065:Buchanan CM, Phillips AR, Cooper GJ (1 Dec 2001).
1705:
1703:
1701:
1684:
1682:
1680:
655:protein serine/threonine kinase activator activity
717:positive regulation of protein kinase B signaling
340:
239:
6991:
6923:Macrophage-stimulating protein (MSP; HLP, HGFLP)
2449:Firth SM, Ganeshprasad U, Baxter RC (Jan 1998).
4564:Heparin-binding EGF-like growth factor (HB-EGF)
4247:Heparin-binding EGF-like growth factor (HB-EGF)
2313:
2311:
2235:
1698:
1677:
1639:Insulin-like growth factor 2 has been shown to
747:positive regulation of mitotic nuclear division
1779:
1710:GRCm38: Ensembl release 89: ENSMUSG00000048583
1467:being transcribed from both parental alleles.
802:positive regulation of protein phosphorylation
6975:Additional growth factor receptor modulators:
4061:
3243:
2753:
2692:
2493:
7015:Insulin-like growth factor receptor agonists
5329:Insulin-like growth factor-2 (somatomedin A)
5211:Insulin-like growth factor-2 (somatomedin A)
5201:Insulin-like growth factor-1 (somatomedin C)
2593:Insulin-Like Growth Factor Signaling in Fish
2590:
2555:
2360:
2308:
2194:
2009:
1843:
2442:
2407:
2401:
1857:
1689:GRCh38: Ensembl release 89: ENSG00000167244
1529:IGF-2 exerts its effects by binding to the
645:insulin-like growth factor receptor binding
4068:
4054:
3250:
3236:
2760:
2746:
2699:
2685:
722:regulation of transcription, DNA-templated
2669:at the U.S. National Library of Medicine
2573:
2529:Comparative Biochemistry and Physiology B
2466:
2425:
2384:
2335:
2263:
2253:
2090:
2041:
1992:
1938:DNA Methylation and Complex Human Disease
1935:
1915:DNA Methylation and Complex Human Disease
1912:
1889:
1586:IGF-2 is sometimes produced in excess in
867:regulation of muscle cell differentiation
837:positive regulation of catalytic activity
777:regulation of signaling receptor activity
6933:Migration-stimulating factor (MSF; PRG4)
4262:Transforming growth factor alpha (TGFα)
2229:
1822:
1441:15.5, a region which contains numerous
6992:
6836:Connective tissue growth factor (CTGF)
6899:Hepatoma-derived growth factor (HDGF)
4049:
3231:
2741:
2680:
1661:Insulin-like growth factor 2 receptor
1581:
345:
306:
301:
244:
203:
198:
1537:(also called the cation-independent
1404:that share structural similarity to
862:striated muscle cell differentiation
752:positive regulation of cell division
2455:The Journal of Biological Chemistry
2414:The Journal of Biological Chemistry
757:positive regulation of MAPK cascade
13:
2767:
2486:
2302:10.1111/j.1439-0531.1993.tb00129.x
1666:Insulin-like growth factor II IRES
1596:non-islet hypoglycemic cell tumors
822:regulation of histone modification
737:multicellular organism development
712:insulin receptor signaling pathway
14:
7031:
7010:Hormones of the somatotropic axis
2660:
2591:Wood AW, Duan C, Bern HA (2005).
2556:Kalli KR, Conover CA (May 2003).
1423:
6918:Leukemia inhibitory factor (LIF)
3738:5-Methoxy-N,N-dimethyltryptamine
2717:
2408:Twigg SM, Baxter RC (Mar 1998).
2290:Reproduction in Domestic Animals
2215:10.1097/01243894-200607000-00016
872:embryonic placenta morphogenesis
581:
574:
567:
329:
322:
316:
293:
228:
221:
215:
190:
27:
6086:Negative allosteric modulators:
3074:Relaxin family peptide hormones
2706:
2280:
2151:
2115:
2058:
1952:
1929:
1906:
1826:iGenetics: A Molecular Approach
1763:"Insulin-Like Growth Factor II"
1634:
1478:of the gene, by binding to the
6404:Gossypetin (3,5,7,8,3',4'-HHF)
5595:Platelet-derived growth factor
1870:Molecular and Cellular Biology
1816:
1773:
1755:
1737:
1719:
797:embryonic placenta development
792:in utero embryonic development
772:carbohydrate metabolic process
592:More reference expression data
547:More reference expression data
1:
6610:Placental growth factor (PGF)
2667:Insulin-Like+Growth+Factor+II
2601:10.1016/S0074-7696(05)43004-1
2541:10.1016/S0305-0491(98)10106-2
2508:10.1016/S1357-2725(98)00048-X
2337:10.1016/S0014-5793(01)03204-5
2160:Am J Physiol Endocrinol Metab
1794:10.1016/s0006-8993(98)00783-5
1671:
1631:) affects IGF II expression.
1333:Available protein structures:
817:exocrine pancreas development
314:
213:
7000:Genes on human chromosome 11
6894:Glia maturation factor (GMF)
5403:Glypromate (GPE, (1-3)IGF-1)
3257:
2203:Journal of Thoracic Oncology
1539:mannose 6-phosphate receptor
1418:insulin-like growth factor 1
1394:Insulin-like growth factor 2
681:platelet alpha granule lumen
7:
1654:
1620:Beckwith-Wiedemann syndrome
1517:
707:skeletal system development
443:stromal cell of endometrium
10:
7036:
6826:Colony-stimulating factors
6818:Additional growth factors:
3906:Insulin-like growth factor
3047:Insulin-like growth factor
2172:10.1152/ajpendo.00401.2021
1572:
1474:is involved in repressing
1400:) is one of three protein
812:animal organ morphogenesis
787:osteoblast differentiation
7020:Insulin receptor agonists
6810:
6597:
6492:
6261:
6174:SNA-120 (pegylated K252a)
6001:
5992:
5972:
5886:
5863:
5832:
5801:
5770:
5734:
5725:
5577:
5420:
5353:
5346:(against IGF-1 and IGF-2)
5315:
5308:(against IGF-1 and IGF-2)
5182:
5173:
4991:
4968:
4908:
4827:
4694:
4611:
4602:
4541:
4487:
4400:
4204:
4195:
4164:
4086:
4009:
3976:
3958:
3930:
3895:
3867:
3829:
3806:
3797:
3757:
3750:
3718:
3680:
3643:
3600:
3572:
3563:
3545:
3499:
3432:
3358:
3335:
3287:
3265:
3204:
3166:
3133:
3070:
3039:
3028:
2993:
2965:
2923:
2884:
2828:
2784:
2775:
2712:
2083:10.1042/0264-6021:3600431
1745:"Mouse PubMed Reference:"
1727:"Human PubMed Reference:"
1629:polychlorinated biphenyls
1375:
1355:
1337:
1332:
1328:
1316:
1304:
1296:
1291:
1286:
1271:
1266:
1262:
1255:
1239:
1220:
1189:
1185:
1152:
1148:
1141:
1110:
1106:
1073:
1069:
1062:
1049:
1045:
1030:
1026:
1017:
1004:
1000:
985:
981:
972:
959:
955:
940:
936:
927:
912:
905:
901:
885:
742:glucose metabolic process
610:
606:
589:
566:
557:
544:
493:
484:
431:
422:
392:
384:
380:
363:
350:
313:
292:
283:
279:
262:
249:
212:
189:
180:
176:
131:
128:
118:
111:
106:
71:
66:
49:
44:
39:
35:
26:
21:
5010:Hepatocyte growth factor
4569:Neuregulins (heregulins)
4500:Neuregulins (heregulins)
4444:Trastuzumab duocarmazine
4157:(against angiopoietin 2)
4151:(against angiopoietin 3)
2671:Medical Subject Headings
2630:. 65 Suppl 3 (3): 50–8.
2255:10.1186/1471-2164-14-472
1233:Chr 7: 142.2 – 142.22 Mb
660:receptor ligand activity
625:insulin receptor binding
4357:Depatuxizumab mafodotin
2887:FGF homologous factors:
2562:Frontiers in Bioscience
2427:10.1074/jbc.273.11.6074
2386:10.1210/jcem.86.10.7936
1608:paraneoplastic syndrome
497:extraembryonic membrane
6980:(neurotrophin mixture)
6968:Wnt signaling proteins
6649:Allosteric modulators:
6369:Norwogonin (5,7,8-THF)
4589:5 (tomoregulin, TMEFF)
4439:Trastuzumab deruxtecan
4077:Growth factor receptor
3733:N,N-Dimethyltryptamine
3710:Pancreatic polypeptide
2468:10.1074/jbc.273.5.2631
2034:10.1038/emboj.2011.293
1226:Chr 11: 2.13 – 2.16 Mb
732:platelet degranulation
640:growth factor activity
525:intra-embryonic coelom
6908:T-cell growth factors
5165:Telisotuzumab vedotin
4449:Trastuzumab emtansine
1882:10.1128/MCB.19.5.3278
1604:Doege-Potter syndrome
206:Chromosome 11 (human)
5493:EVT-901 (SAR-127963)
5226:Mecasermin rinfabate
3168:Vascular endothelial
1936:Neidhart, M (2016).
1913:Neidhart, M (2016).
676:extracellular region
347:7 F5|7 87.99 cM
308:Chromosome 7 (mouse)
67:List of PDB id codes
40:Available structures
4019:Natriuretic peptide
3337:Posterior pituitary
3322:Somatostatin (GHIH)
1985:10.1038/nature09667
1977:2011Natur.469..491C
1823:Russell PJ (2009).
686:extracellular space
467:canal of the cervix
447:right lobe of liver
6659:Kinase inhibitors:
6522:Kinase inhibitors:
6421:Kinase inhibitors:
6096:Kinase inhibitors:
5911:Kinase inhibitors:
5871:Kinase inhibitors:
5852:Kinase inhibitors:
5821:Kinase inhibitors:
5790:Kinase inhibitors:
5759:Kinase inhibitors:
5619:Kinase inhibitors:
5233:Kinase inhibitors:
5027:Kinase inhibitors:
4816:Kinase inhibitors:
4809:Aprutumab ixadotin
4456:Kinase inhibitors:
4269:Kinase inhibitors:
4126:Kinase inhibitors:
3360:Anterior pituitary
2137:10.1039/c6ob01455k
1582:Clinical relevance
1007:ENSMUSG00000048583
695:Biological process
669:Cellular component
618:Molecular function
463:right uterine tube
6987:
6986:
6593:
6592:
6354:N-Acetylserotonin
6253:ReN-1820 (TrkAd5)
5882:
5881:
5416:
5415:
5361:Binding proteins:
5020:Dihexa (PNB-0408)
4987:
4986:
4598:
4597:
4512:6 (neuroglycan C)
4232:EGF (urogastrone)
4210:
4043:
4042:
4039:
4038:
3926:
3925:
3746:
3745:
3676:
3675:
3428:
3427:
3225:
3224:
3129:
3128:
2961:
2960:
2735:
2734:
2636:10.1159/000091506
2131:(39): 9225–9238.
2077:(Pt 2): 431–439.
1836:978-0-321-61022-5
1447:homologous region
1391:
1390:
1387:
1386:
1382:structure summary
1282:
1281:
1278:
1277:
1251:
1250:
1216:
1215:
1179:
1178:
1137:
1136:
1100:
1099:
1058:
1057:
1039:
1038:
1013:
1012:
994:
993:
968:
967:
949:
948:
897:
896:
602:
601:
598:
597:
553:
552:
540:
539:
478:
477:
455:left uterine tube
376:
375:
275:
274:
102:
101:
98:
97:
50:Ortholog search:
7027:
7005:Peptide hormones
6799:Decoy receptors:
6772:Alacizumab pegol
6250:Decoy receptors:
5999:
5998:
5904:Stem cell factor
5845:Persephin (PSPN)
5783:Neurturin (NRTN)
5732:
5731:
5569:LEVI-04 (p75-Fc)
5566:Decoy receptors:
5180:
5179:
4609:
4608:
4208:
4202:
4201:
4070:
4063:
4056:
4047:
4046:
3804:
3803:
3799:Digestive system
3755:
3754:
3570:
3569:
3509:Thyroid hormones
3285:
3284:
3274:
3273:
3252:
3245:
3238:
3229:
3228:
3135:Platelet-derived
3077:
3050:
3037:
3036:
2931:
2889:
2835:
2792:
2782:
2781:
2762:
2755:
2748:
2739:
2738:
2721:
2701:
2694:
2687:
2678:
2677:
2655:
2628:Hormone Research
2622:
2587:
2577:
2552:
2519:
2481:
2480:
2470:
2446:
2440:
2439:
2429:
2405:
2399:
2398:
2388:
2364:
2358:
2357:
2339:
2315:
2306:
2305:
2284:
2278:
2277:
2267:
2257:
2233:
2227:
2226:
2198:
2192:
2191:
2166:(6): E467–E479.
2155:
2149:
2148:
2119:
2113:
2112:
2094:
2062:
2056:
2055:
2045:
2022:The EMBO Journal
2013:
2007:
2006:
1996:
1956:
1950:
1941:
1933:
1927:
1918:
1910:
1904:
1903:
1893:
1861:
1855:
1854:
1847:
1841:
1840:
1820:
1814:
1813:
1777:
1771:
1770:
1759:
1753:
1752:
1741:
1735:
1734:
1723:
1717:
1707:
1696:
1686:
1330:
1329:
1284:
1283:
1264:
1263:
1235:
1228:
1211:
1183:
1182:
1174:
1146:
1145:
1142:RefSeq (protein)
1132:
1104:
1103:
1095:
1067:
1066:
1043:
1042:
1024:
1023:
998:
997:
979:
978:
953:
952:
934:
933:
903:
902:
650:integrin binding
630:hormone activity
608:
607:
594:
585:
578:
571:
564:
563:
549:
505:genital tubercle
489:
487:Top expressed in
482:
481:
427:
425:Top expressed in
420:
419:
399:
398:
382:
381:
372:
359:
348:
333:
326:
320:
309:
297:
281:
280:
271:
258:
247:
232:
225:
219:
208:
194:
178:
177:
172:
170:IGF2 - orthologs
123:
116:
93:
64:
63:
58:
37:
36:
31:
19:
18:
7035:
7034:
7030:
7029:
7028:
7026:
7025:
7024:
6990:
6989:
6988:
6983:
6928:Midkine (NEGF2)
6806:
6589:
6488:
6257:
6195:ABT-110 (PG110)
5988:
5968:
5878:
5859:
5828:
5797:
5766:
5721:
5573:
5511:ABT-110 (PG110)
5412:
5349:
5311:
5169:
4983:
4964:
4904:
4901:(against FGF23)
4823:
4690:
4594:
4537:
4483:
4396:
4207:
4191:
4160:
4082:
4074:
4044:
4035:
4005:
3972:
3954:
3922:
3891:
3863:
3825:
3793:
3742:
3714:
3672:
3639:
3596:
3559:
3541:
3525:
3517:
3495:
3479:Adrenal medulla
3472:Androstenedione
3424:
3354:
3331:
3279:
3268:
3261:
3256:
3226:
3221:
3200:
3162:
3125:
3071:
3066:
3040:
3031:
3024:
2989:
2967:EGF-like domain
2957:
2924:
2919:
2885:
2880:
2829:
2824:
2785:
2771:
2766:
2736:
2731:
2728:
2722:
2708:
2705:
2663:
2658:
2611:
2489:
2487:Further reading
2484:
2447:
2443:
2406:
2402:
2379:(10): 4943–50.
2365:
2361:
2316:
2309:
2285:
2281:
2234:
2230:
2199:
2195:
2156:
2152:
2125:Org Biomol Chem
2120:
2116:
2063:
2059:
2028:(19): 4071–83.
2014:
2010:
1971:(7331): 491–7.
1957:
1953:
1934:
1930:
1911:
1907:
1862:
1858:
1849:
1848:
1844:
1837:
1821:
1817:
1778:
1774:
1761:
1760:
1756:
1743:
1742:
1738:
1725:
1724:
1720:
1708:
1699:
1687:
1678:
1674:
1657:
1637:
1584:
1575:
1565:memory such as
1520:
1445:. In mice this
1443:imprinted genes
1428:In humans, the
1426:
1273:View/Edit Mouse
1268:View/Edit Human
1231:
1224:
1221:Location (UCSC)
1207:
1203:
1199:
1195:
1191:
1170:
1166:
1162:
1158:
1154:
1128:
1124:
1120:
1116:
1112:
1091:
1087:
1083:
1079:
1075:
988:ENSG00000167244
881:
690:
664:
635:protein binding
590:
580:
579:
573:
572:
545:
536:
531:
529:rhombencephalon
527:
523:
519:
515:
511:
507:
503:
499:
485:
474:
469:
465:
461:
459:muscle of thigh
457:
453:
449:
445:
441:
437:
423:
367:
354:
346:
336:
335:
334:
327:
307:
284:Gene location (
266:
253:
245:
235:
234:
233:
226:
204:
181:Gene location (
132:
119:
112:
73:
51:
17:
16:Protein hormone
12:
11:
5:
7033:
7023:
7022:
7017:
7012:
7007:
7002:
6985:
6984:
6982:
6981:
6971:
6970:
6965:
6958:Thrombopoietin
6955:
6950:
6945:
6940:
6935:
6930:
6925:
6920:
6915:
6901:
6896:
6891:
6886:
6879:Erythropoietin
6876:
6838:
6833:
6823:
6821:Adrenomedullin
6814:
6812:
6808:
6807:
6805:
6804:
6795:
6794:
6789:
6784:
6779:
6774:
6765:
6764:
6759:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6674:
6669:
6664:
6655:
6654:
6645:
6644:
6622:
6617:
6612:
6603:
6601:
6595:
6594:
6591:
6590:
6588:
6587:
6582:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6542:
6537:
6532:
6527:
6518:
6517:
6512:
6507:
6498:
6496:
6490:
6489:
6487:
6486:
6481:
6476:
6471:
6466:
6461:
6456:
6451:
6446:
6441:
6436:
6431:
6426:
6417:
6416:
6407:
6406:
6401:
6396:
6387:
6386:
6381:
6376:
6371:
6366:
6361:
6356:
6351:
6346:
6341:
6336:
6331:
6326:
6321:
6316:
6311:
6306:
6301:
6296:
6291:
6286:
6284:4'-DMA-7,8-DHF
6281:
6276:
6267:
6265:
6259:
6258:
6256:
6255:
6246:
6245:
6233:
6232:
6227:
6222:
6217:
6212:
6207:
6202:
6197:
6178:
6177:
6171:
6166:
6161:
6156:
6151:
6146:
6141:
6136:
6131:
6126:
6121:
6116:
6111:
6106:
6101:
6092:
6091:
6082:
6081:
6076:
6071:
6066:
6057:
6056:
6051:
6046:
6044:Gambogic amide
6041:
6036:
6031:
6026:
6021:
6016:
6007:
6005:
5996:
5990:
5989:
5987:
5986:
5978:
5976:
5970:
5969:
5967:
5966:
5961:
5956:
5951:
5946:
5941:
5936:
5931:
5926:
5921:
5916:
5907:
5906:
5901:
5892:
5890:
5884:
5883:
5880:
5879:
5877:
5876:
5867:
5865:
5861:
5860:
5858:
5857:
5848:
5847:
5838:
5836:
5830:
5829:
5827:
5826:
5817:
5816:
5814:Artemin (ARTN)
5807:
5805:
5799:
5798:
5796:
5795:
5786:
5785:
5776:
5774:
5768:
5767:
5765:
5764:
5755:
5754:
5749:
5740:
5738:
5729:
5723:
5722:
5720:
5719:
5714:
5709:
5700:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5639:
5634:
5629:
5624:
5615:
5614:
5592:
5583:
5581:
5575:
5574:
5572:
5571:
5562:
5561:
5549:
5548:
5543:
5538:
5533:
5528:
5523:
5518:
5513:
5501:
5500:
5495:
5490:
5485:
5476:
5475:
5470:
5465:
5460:
5455:
5450:
5445:
5440:
5435:
5426:
5424:
5418:
5417:
5414:
5413:
5411:
5410:
5405:
5396:
5395:
5357:
5355:
5351:
5350:
5348:
5347:
5341:
5332:
5331:
5321:
5319:
5313:
5312:
5310:
5309:
5303:
5298:
5293:
5288:
5283:
5278:
5273:
5268:
5259:
5258:
5253:
5248:
5243:
5238:
5229:
5228:
5223:
5218:
5213:
5208:
5203:
5198:
5188:
5186:
5177:
5171:
5170:
5168:
5167:
5162:
5157:
5152:
5147:
5142:
5137:
5128:
5127:
5122:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5057:
5052:
5047:
5042:
5037:
5032:
5023:
5022:
5013:
5012:
5007:
4997:
4995:
4989:
4988:
4985:
4984:
4982:
4981:
4972:
4970:
4966:
4965:
4963:
4962:
4957:
4923:
4914:
4912:
4906:
4905:
4903:
4902:
4892:
4891:
4886:
4881:
4876:
4842:
4833:
4831:
4825:
4824:
4822:
4821:
4812:
4811:
4806:
4797:
4796:
4791:
4786:
4781:
4776:
4771:
4709:
4700:
4698:
4692:
4691:
4689:
4688:
4683:
4678:
4673:
4668:
4626:
4617:
4615:
4606:
4600:
4599:
4596:
4595:
4593:
4592:
4566:
4561:
4556:
4547:
4545:
4539:
4538:
4536:
4535:
4530:
4525:
4516:
4515:
4493:
4491:
4485:
4484:
4482:
4481:
4476:
4471:
4466:
4461:
4452:
4451:
4446:
4441:
4436:
4431:
4426:
4417:
4416:
4406:
4404:
4398:
4397:
4395:
4394:
4389:
4384:
4379:
4374:
4369:
4364:
4359:
4354:
4349:
4340:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4265:
4264:
4259:
4254:
4249:
4244:
4239:
4234:
4229:
4224:
4214:
4212:
4199:
4193:
4192:
4190:
4189:
4184:
4179:
4170:
4168:
4162:
4161:
4159:
4158:
4152:
4142:
4141:
4136:
4131:
4122:
4121:
4119:Angiopoietin 3
4116:
4114:Angiopoietin 2
4107:
4106:
4104:Angiopoietin 4
4101:
4099:Angiopoietin 1
4092:
4090:
4084:
4083:
4073:
4072:
4065:
4058:
4050:
4041:
4040:
4037:
4036:
4034:
4033:
4032:
4031:
4026:
4015:
4013:
4007:
4006:
4004:
4003:
3998:
3993:
3988:
3982:
3980:
3974:
3973:
3971:
3970:
3964:
3962:
3956:
3955:
3953:
3952:
3947:
3942:
3936:
3934:
3932:Adipose tissue
3928:
3927:
3924:
3923:
3921:
3920:
3919:
3918:
3913:
3902:
3900:
3893:
3892:
3890:
3889:
3884:
3879:
3877:Enteroglucagon
3873:
3871:
3865:
3864:
3862:
3861:
3856:
3851:
3846:
3841:
3835:
3833:
3827:
3826:
3824:
3823:
3818:
3812:
3810:
3801:
3795:
3794:
3792:
3791:
3786:
3781:
3780:
3779:
3777:Beta thymosins
3774:
3763:
3761:
3752:
3748:
3747:
3744:
3743:
3741:
3740:
3735:
3730:
3724:
3722:
3716:
3715:
3713:
3712:
3707:
3702:
3697:
3692:
3686:
3684:
3678:
3677:
3674:
3673:
3671:
3670:
3665:
3660:
3655:
3649:
3647:
3641:
3640:
3638:
3637:
3632:
3627:
3622:
3617:
3612:
3606:
3604:
3598:
3597:
3595:
3594:
3589:
3584:
3578:
3576:
3567:
3561:
3560:
3558:
3557:
3551:
3549:
3543:
3542:
3540:
3539:
3534:
3529:
3528:
3527:
3523:
3519:
3515:
3505:
3503:
3497:
3496:
3494:
3493:
3492:
3491:
3489:Norepinephrine
3486:
3476:
3475:
3474:
3469:
3464:
3459:
3454:
3449:
3442:Adrenal cortex
3438:
3436:
3430:
3429:
3426:
3425:
3423:
3422:
3417:
3416:
3415:
3410:
3405:
3400:
3395:
3385:
3380:
3375:
3370:
3364:
3362:
3356:
3355:
3353:
3352:
3347:
3341:
3339:
3333:
3332:
3330:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3293:
3291:
3282:
3271:
3263:
3262:
3255:
3254:
3247:
3240:
3232:
3223:
3222:
3220:
3219:
3214:
3208:
3206:
3202:
3201:
3199:
3198:
3193:
3188:
3183:
3178:
3172:
3170:
3164:
3163:
3161:
3160:
3155:
3150:
3145:
3139:
3137:
3131:
3130:
3127:
3126:
3124:
3123:
3122:
3121:
3116:
3111:
3101:
3096:
3091:
3086:
3080:
3078:
3068:
3067:
3065:
3064:
3059:
3053:
3051:
3034:
3032:Relaxin family
3026:
3025:
3023:
3022:
3021:
3020:
3015:
3010:
2999:
2997:
2991:
2990:
2988:
2987:
2982:
2977:
2971:
2969:
2963:
2962:
2959:
2958:
2956:
2955:
2950:
2945:
2940:
2934:
2932:
2921:
2920:
2918:
2917:
2911:
2905:
2899:
2892:
2890:
2882:
2881:
2879:
2878:
2865:
2852:
2838:
2836:
2826:
2825:
2823:
2822:
2809:
2795:
2793:
2779:
2773:
2772:
2769:Growth factors
2765:
2764:
2757:
2750:
2742:
2733:
2732:
2730:
2729:
2723:
2716:
2713:
2710:
2709:
2704:
2703:
2696:
2689:
2681:
2675:
2674:
2662:
2661:External links
2659:
2657:
2656:
2623:
2609:
2588:
2568:(4): d714–22.
2553:
2520:
2490:
2488:
2485:
2483:
2482:
2441:
2420:(11): 6074–9.
2400:
2359:
2307:
2296:(3): 215–216.
2279:
2228:
2193:
2150:
2114:
2057:
2008:
1951:
1947:978-0124201941
1928:
1905:
1876:(5): 3278–88.
1856:
1842:
1835:
1815:
1782:Brain Research
1772:
1754:
1736:
1718:
1697:
1675:
1673:
1670:
1669:
1668:
1663:
1656:
1653:
1636:
1633:
1616:pleural cavity
1583:
1580:
1574:
1571:
1535:IGF-2 receptor
1531:IGF-1 receptor
1519:
1516:
1439:chromosome 11p
1437:is located on
1425:
1424:Gene structure
1422:
1389:
1388:
1385:
1384:
1379:
1373:
1372:
1359:
1353:
1352:
1342:
1335:
1334:
1326:
1325:
1320:
1314:
1313:
1308:
1302:
1301:
1298:
1294:
1293:
1289:
1288:
1280:
1279:
1276:
1275:
1270:
1260:
1259:
1253:
1252:
1249:
1248:
1246:
1244:
1237:
1236:
1229:
1222:
1218:
1217:
1214:
1213:
1187:
1186:
1180:
1177:
1176:
1150:
1149:
1143:
1139:
1138:
1135:
1134:
1108:
1107:
1101:
1098:
1097:
1071:
1070:
1064:
1060:
1059:
1056:
1055:
1047:
1046:
1040:
1037:
1036:
1028:
1027:
1021:
1015:
1014:
1011:
1010:
1002:
1001:
995:
992:
991:
983:
982:
976:
970:
969:
966:
965:
957:
956:
950:
947:
946:
938:
937:
931:
925:
924:
919:
914:
910:
909:
899:
898:
895:
894:
883:
882:
880:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
698:
696:
692:
691:
689:
688:
683:
678:
672:
670:
666:
665:
663:
662:
657:
652:
647:
642:
637:
632:
627:
621:
619:
615:
614:
604:
603:
600:
599:
596:
595:
587:
586:
561:
555:
554:
551:
550:
542:
541:
538:
537:
535:
534:
530:
526:
522:
518:
514:
513:tail of embryo
510:
506:
502:
498:
494:
491:
490:
479:
476:
475:
473:
472:
471:left ventricle
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
429:
428:
416:
415:
407:
396:
390:
389:
386:RNA expression
378:
377:
374:
373:
365:
361:
360:
352:
349:
344:
338:
337:
328:
321:
315:
311:
310:
305:
299:
298:
290:
289:
277:
276:
273:
272:
264:
260:
259:
251:
248:
243:
237:
236:
227:
220:
214:
210:
209:
202:
196:
195:
187:
186:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
7032:
7021:
7018:
7016:
7013:
7011:
7008:
7006:
7003:
7001:
6998:
6997:
6995:
6979:
6976:
6973:
6972:
6969:
6966:
6963:
6959:
6956:
6954:
6951:
6949:
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6913:
6909:
6905:
6902:
6900:
6897:
6895:
6892:
6890:
6887:
6884:
6880:
6877:
6874:
6870:
6866:
6862:
6858:
6854:
6850:
6846:
6842:
6839:
6837:
6834:
6831:
6827:
6824:
6822:
6819:
6816:
6815:
6813:
6809:
6803:
6800:
6797:
6796:
6793:
6790:
6788:
6785:
6783:
6780:
6778:
6775:
6773:
6770:
6767:
6766:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6705:
6703:
6700:
6698:
6695:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6665:
6663:
6660:
6657:
6656:
6653:
6652:Cyclotraxin B
6650:
6647:
6646:
6642:
6638:
6634:
6630:
6626:
6623:
6621:
6618:
6616:
6613:
6611:
6608:
6605:
6604:
6602:
6600:
6596:
6586:
6583:
6581:
6578:
6576:
6573:
6571:
6568:
6566:
6565:Larotrectinib
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6520:
6519:
6516:
6513:
6511:
6508:
6506:
6503:
6500:
6499:
6497:
6495:
6491:
6485:
6482:
6480:
6477:
6475:
6472:
6470:
6467:
6465:
6464:Larotrectinib
6462:
6460:
6457:
6455:
6452:
6450:
6447:
6445:
6442:
6440:
6437:
6435:
6432:
6430:
6427:
6425:
6422:
6419:
6418:
6415:
6412:
6409:
6408:
6405:
6402:
6400:
6399:Cyclotraxin B
6397:
6395:
6392:
6389:
6388:
6385:
6382:
6380:
6377:
6375:
6372:
6370:
6367:
6365:
6362:
6360:
6357:
6355:
6352:
6350:
6347:
6345:
6342:
6340:
6337:
6335:
6332:
6330:
6327:
6325:
6322:
6320:
6317:
6315:
6312:
6310:
6309:Amitriptyline
6307:
6305:
6302:
6300:
6297:
6295:
6292:
6290:
6287:
6285:
6282:
6280:
6277:
6275:
6272:
6269:
6268:
6266:
6264:
6260:
6254:
6251:
6248:
6247:
6244:
6241:
6238:
6235:
6234:
6231:
6228:
6226:
6223:
6221:
6218:
6216:
6213:
6211:
6208:
6206:
6203:
6201:
6198:
6196:
6193:
6189:
6186:
6185:Against TrkA:
6183:
6180:
6179:
6175:
6172:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6150:
6147:
6145:
6142:
6140:
6139:Larotrectinib
6137:
6135:
6132:
6130:
6127:
6125:
6122:
6120:
6117:
6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6094:
6093:
6090:
6087:
6084:
6083:
6080:
6077:
6075:
6072:
6070:
6069:Dexamethasone
6067:
6065:
6062:
6059:
6058:
6055:
6052:
6050:
6047:
6045:
6042:
6040:
6037:
6035:
6032:
6030:
6027:
6025:
6022:
6020:
6017:
6015:
6014:Amitriptyline
6012:
6009:
6008:
6006:
6004:
6000:
5997:
5995:
5991:
5984:
5980:
5979:
5977:
5975:
5971:
5965:
5962:
5960:
5957:
5955:
5952:
5950:
5947:
5945:
5942:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5909:
5908:
5905:
5902:
5900:
5897:
5894:
5893:
5891:
5889:
5885:
5875:
5872:
5869:
5868:
5866:
5862:
5856:
5853:
5850:
5849:
5846:
5843:
5840:
5839:
5837:
5835:
5831:
5825:
5822:
5819:
5818:
5815:
5812:
5809:
5808:
5806:
5804:
5800:
5794:
5791:
5788:
5787:
5784:
5781:
5778:
5777:
5775:
5773:
5769:
5763:
5760:
5757:
5756:
5753:
5750:
5748:
5745:
5742:
5741:
5739:
5737:
5733:
5730:
5728:
5724:
5718:
5715:
5713:
5710:
5708:
5705:
5702:
5701:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5623:
5620:
5617:
5616:
5612:
5608:
5604:
5600:
5596:
5593:
5591:
5588:
5585:
5584:
5582:
5580:
5576:
5570:
5567:
5564:
5563:
5560:
5557:
5554:
5551:
5550:
5547:
5544:
5542:
5539:
5537:
5534:
5532:
5529:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5506:
5503:
5502:
5499:
5496:
5494:
5491:
5489:
5488:Dexamethasone
5486:
5484:
5481:
5478:
5477:
5474:
5471:
5469:
5466:
5464:
5461:
5459:
5456:
5454:
5451:
5449:
5446:
5444:
5441:
5439:
5436:
5434:
5431:
5428:
5427:
5425:
5423:
5419:
5409:
5406:
5404:
5401:
5398:
5397:
5393:
5389:
5385:
5381:
5377:
5373:
5369:
5365:
5362:
5359:
5358:
5356:
5352:
5345:
5342:
5340:
5337:
5334:
5333:
5330:
5326:
5323:
5322:
5320:
5318:
5314:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5261:
5260:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5231:
5230:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5196:des(1-3)IGF-1
5193:
5190:
5189:
5187:
5185:
5181:
5178:
5176:
5172:
5166:
5163:
5161:
5160:Telisotuzumab
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5130:
5129:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5025:
5024:
5021:
5018:
5017:Potentiators:
5015:
5014:
5011:
5008:
5006:
5002:
4999:
4998:
4996:
4994:
4990:
4980:
4977:
4974:
4973:
4971:
4967:
4961:
4958:
4955:
4951:
4947:
4943:
4939:
4935:
4931:
4927:
4924:
4922:
4919:
4916:
4915:
4913:
4911:
4907:
4900:
4897:
4894:
4893:
4890:
4887:
4885:
4882:
4880:
4879:Selpercatinib
4877:
4874:
4870:
4866:
4862:
4858:
4854:
4850:
4846:
4843:
4841:
4838:
4835:
4834:
4832:
4830:
4826:
4820:
4817:
4814:
4813:
4810:
4807:
4805:
4802:
4799:
4798:
4795:
4792:
4790:
4787:
4785:
4784:Selpercatinib
4782:
4780:
4777:
4775:
4772:
4769:
4765:
4761:
4757:
4753:
4749:
4745:
4741:
4737:
4733:
4729:
4725:
4721:
4717:
4713:
4710:
4708:
4705:
4702:
4701:
4699:
4697:
4693:
4687:
4684:
4682:
4679:
4677:
4676:Selpercatinib
4674:
4672:
4669:
4666:
4662:
4658:
4654:
4650:
4646:
4642:
4638:
4634:
4630:
4627:
4625:
4622:
4619:
4618:
4616:
4614:
4610:
4607:
4605:
4601:
4590:
4586:
4582:
4578:
4574:
4570:
4567:
4565:
4562:
4560:
4557:
4555:
4552:
4549:
4548:
4546:
4544:
4540:
4534:
4531:
4529:
4526:
4524:
4521:
4518:
4517:
4513:
4509:
4505:
4501:
4498:
4495:
4494:
4492:
4490:
4486:
4480:
4477:
4475:
4472:
4470:
4467:
4465:
4462:
4460:
4457:
4454:
4453:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4419:
4418:
4415:
4411:
4408:
4407:
4405:
4403:
4399:
4393:
4390:
4388:
4385:
4383:
4380:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4352:Depatuxizumab
4350:
4348:
4345:
4342:
4341:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4267:
4266:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4233:
4230:
4228:
4225:
4223:
4219:
4216:
4215:
4213:
4211:
4203:
4200:
4198:
4194:
4188:
4185:
4183:
4180:
4178:
4175:
4172:
4171:
4169:
4167:
4163:
4156:
4153:
4150:
4147:
4144:
4143:
4140:
4137:
4135:
4132:
4130:
4127:
4124:
4123:
4120:
4117:
4115:
4112:
4109:
4108:
4105:
4102:
4100:
4097:
4094:
4093:
4091:
4089:
4085:
4081:
4078:
4071:
4066:
4064:
4059:
4057:
4052:
4051:
4048:
4030:
4027:
4025:
4022:
4021:
4020:
4017:
4016:
4014:
4012:
4008:
4002:
4001:Prostaglandin
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3983:
3981:
3979:
3975:
3969:
3966:
3965:
3963:
3961:
3957:
3951:
3948:
3946:
3943:
3941:
3938:
3937:
3935:
3933:
3929:
3917:
3914:
3912:
3909:
3908:
3907:
3904:
3903:
3901:
3898:
3894:
3888:
3885:
3883:
3880:
3878:
3875:
3874:
3872:
3870:
3866:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3836:
3834:
3832:
3828:
3822:
3819:
3817:
3814:
3813:
3811:
3809:
3805:
3802:
3800:
3796:
3790:
3787:
3785:
3782:
3778:
3775:
3773:
3770:
3769:
3768:
3765:
3764:
3762:
3760:
3756:
3753:
3749:
3739:
3736:
3734:
3731:
3729:
3726:
3725:
3723:
3721:
3717:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3687:
3685:
3683:
3679:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3650:
3648:
3646:
3642:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3607:
3605:
3603:
3599:
3593:
3590:
3588:
3585:
3583:
3580:
3579:
3577:
3575:
3571:
3568:
3566:
3562:
3556:
3553:
3552:
3550:
3548:
3544:
3538:
3535:
3533:
3530:
3526:
3520:
3518:
3512:
3511:
3510:
3507:
3506:
3504:
3502:
3498:
3490:
3487:
3485:
3482:
3481:
3480:
3477:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3444:
3443:
3440:
3439:
3437:
3435:
3431:
3421:
3418:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3390:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3365:
3363:
3361:
3357:
3351:
3348:
3346:
3343:
3342:
3340:
3338:
3334:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3294:
3292:
3290:
3286:
3283:
3281:
3278:Hypothalamic–
3275:
3272:
3270:
3264:
3260:
3253:
3248:
3246:
3241:
3239:
3234:
3233:
3230:
3218:
3215:
3213:
3210:
3209:
3207:
3203:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3173:
3171:
3169:
3165:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3140:
3138:
3136:
3132:
3120:
3117:
3115:
3112:
3110:
3107:
3106:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3081:
3079:
3076:
3075:
3069:
3063:
3060:
3058:
3055:
3054:
3052:
3049:
3048:
3044:
3038:
3035:
3033:
3027:
3019:
3016:
3014:
3011:
3009:
3006:
3005:
3004:
3001:
3000:
2998:
2996:
2992:
2986:
2983:
2981:
2978:
2976:
2973:
2972:
2970:
2968:
2964:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2935:
2933:
2930:
2927:
2926:hormone-like:
2922:
2915:
2912:
2909:
2906:
2903:
2900:
2897:
2894:
2893:
2891:
2888:
2883:
2877:
2873:
2869:
2866:
2864:
2860:
2856:
2853:
2851:
2847:
2843:
2840:
2839:
2837:
2834:
2833:
2827:
2821:
2817:
2813:
2810:
2808:
2804:
2800:
2797:
2796:
2794:
2791:
2789:
2783:
2780:
2778:
2774:
2770:
2763:
2758:
2756:
2751:
2749:
2744:
2743:
2740:
2726:
2720:
2715:
2714:
2711:
2702:
2697:
2695:
2690:
2688:
2683:
2682:
2679:
2672:
2668:
2665:
2664:
2653:
2649:
2645:
2641:
2637:
2633:
2629:
2624:
2620:
2616:
2612:
2610:9780123646477
2606:
2602:
2598:
2594:
2589:
2585:
2581:
2576:
2571:
2567:
2563:
2559:
2554:
2550:
2546:
2542:
2538:
2534:
2530:
2526:
2521:
2517:
2513:
2509:
2505:
2502:(7): 767–71.
2501:
2497:
2492:
2491:
2478:
2474:
2469:
2464:
2461:(5): 2631–8.
2460:
2456:
2452:
2445:
2437:
2433:
2428:
2423:
2419:
2415:
2411:
2404:
2396:
2392:
2387:
2382:
2378:
2374:
2370:
2363:
2355:
2351:
2347:
2343:
2338:
2333:
2329:
2325:
2321:
2314:
2312:
2303:
2299:
2295:
2291:
2283:
2275:
2271:
2266:
2261:
2256:
2251:
2247:
2243:
2239:
2232:
2224:
2220:
2216:
2212:
2209:(6): 588–90.
2208:
2204:
2197:
2189:
2185:
2181:
2177:
2173:
2169:
2165:
2161:
2154:
2146:
2142:
2138:
2134:
2130:
2126:
2118:
2110:
2106:
2102:
2098:
2093:
2088:
2084:
2080:
2076:
2072:
2068:
2061:
2053:
2049:
2044:
2039:
2035:
2031:
2027:
2023:
2019:
2012:
2004:
2000:
1995:
1990:
1986:
1982:
1978:
1974:
1970:
1966:
1962:
1955:
1948:
1944:
1939:
1932:
1925:
1924:9780124201941
1921:
1916:
1909:
1901:
1897:
1892:
1887:
1883:
1879:
1875:
1871:
1867:
1860:
1852:
1846:
1838:
1832:
1828:
1827:
1819:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1783:
1776:
1768:
1764:
1758:
1750:
1746:
1740:
1732:
1728:
1722:
1715:
1711:
1706:
1704:
1702:
1694:
1690:
1685:
1683:
1681:
1676:
1667:
1664:
1662:
1659:
1658:
1652:
1650:
1646:
1642:
1632:
1630:
1625:
1621:
1617:
1613:
1609:
1605:
1601:
1597:
1593:
1589:
1579:
1570:
1568:
1564:
1560:
1556:
1550:
1548:
1542:
1540:
1536:
1532:
1527:
1525:
1515:
1511:
1509:
1504:
1500:
1495:
1491:
1487:
1486:DNA sequences
1483:
1482:
1477:
1473:
1468:
1466:
1465:
1460:
1456:
1452:
1448:
1444:
1440:
1436:
1433:
1432:
1421:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1383:
1380:
1378:
1374:
1371:
1367:
1363:
1360:
1358:
1354:
1350:
1346:
1343:
1340:
1336:
1331:
1327:
1324:
1321:
1319:
1315:
1312:
1309:
1307:
1303:
1299:
1295:
1290:
1285:
1274:
1269:
1265:
1261:
1258:
1254:
1247:
1245:
1242:
1238:
1234:
1230:
1227:
1223:
1219:
1212:
1210:
1206:
1202:
1198:
1194:
1188:
1184:
1181:
1175:
1173:
1169:
1165:
1161:
1157:
1151:
1147:
1144:
1140:
1133:
1131:
1127:
1123:
1119:
1115:
1109:
1105:
1102:
1096:
1094:
1090:
1086:
1082:
1078:
1072:
1068:
1065:
1063:RefSeq (mRNA)
1061:
1054:
1053:
1048:
1044:
1041:
1035:
1034:
1029:
1025:
1022:
1020:
1016:
1009:
1008:
1003:
999:
996:
990:
989:
984:
980:
977:
975:
971:
964:
963:
958:
954:
951:
945:
944:
939:
935:
932:
930:
926:
923:
920:
918:
915:
911:
908:
904:
900:
893:
889:
884:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
699:
697:
694:
693:
687:
684:
682:
679:
677:
674:
673:
671:
668:
667:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
622:
620:
617:
616:
613:
612:Gene ontology
609:
605:
593:
588:
584:
577:
570:
565:
562:
560:
556:
548:
543:
533:mesencephalon
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
495:
492:
488:
483:
480:
470:
466:
462:
458:
454:
451:apex of heart
450:
446:
442:
438:
434:
433:
430:
426:
421:
418:
417:
414:
412:
408:
406:
405:
401:
400:
397:
395:
391:
387:
383:
379:
371:
366:
362:
358:
353:
343:
339:
332:
325:
319:
312:
304:
300:
296:
291:
287:
282:
278:
270:
265:
261:
257:
252:
242:
238:
231:
224:
218:
211:
207:
201:
197:
193:
188:
184:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
6978:Cerebrolysin
6974:
6948:Pleiotrophin
6904:Interleukins
6817:
6798:
6768:
6687:Fruquintinib
6677:Cabozantinib
6658:
6648:
6606:
6570:Lestaurtinib
6521:
6501:
6469:Lestaurtinib
6420:
6410:
6391:Antagonists:
6390:
6324:Deoxygedunin
6279:3,7,8,2'-THF
6270:
6249:
6240:Against NGF:
6239:
6236:
6192:Against NGF:
6191:
6184:
6181:
6144:Lestaurtinib
6095:
6085:
6079:Testosterone
6061:Antagonists:
6060:
6010:
5910:
5895:
5870:
5851:
5841:
5820:
5810:
5789:
5779:
5758:
5743:
5703:
5618:
5586:
5565:
5556:Against NGF:
5555:
5552:
5508:Against NGF:
5507:
5504:
5498:Testosterone
5480:Antagonists:
5479:
5429:
5399:
5360:
5335:
5328:
5324:
5301:Teprotumumab
5262:
5232:
5210:
5191:
5140:Ficlatuzumab
5135:Emibetuzumab
5131:
5085:JNJ-38877605
5055:Cabozantinib
5026:
5016:
5005:Fosgonimeton
5000:
4975:
4917:
4895:
4836:
4819:Infigratinib
4815:
4800:
4703:
4620:
4554:Betacellulin
4550:
4533:Seribantumab
4519:
4496:
4455:
4420:
4414:Unknown/none
4413:
4409:
4343:
4268:
4227:Betacellulin
4222:Amphiregulin
4217:
4209:(ErbB1/HER1)
4173:
4145:
4125:
4111:Antagonists:
4110:
4095:
4088:Angiopoietin
3915:
3784:Thymopoietin
3720:Pineal gland
3705:Somatostatin
3668:Progesterone
3615:Progesterone
3582:Testosterone
3565:Gonadal axis
3537:Thyroid axis
3434:Adrenal axis
3289:Hypothalamus
3072:
3061:
3041:
3030:Insulin/IGF/
2995:TGFβ pathway
2925:
2886:
2830:
2788:FGF receptor
2786:
2724:
2627:
2592:
2575:10.2741/1034
2565:
2561:
2535:(1): 19–26.
2532:
2528:
2499:
2495:
2458:
2454:
2444:
2417:
2413:
2403:
2376:
2372:
2362:
2330:(3): 395–8.
2327:
2324:FEBS Letters
2323:
2293:
2289:
2282:
2245:
2242:BMC Genomics
2241:
2231:
2206:
2202:
2196:
2163:
2159:
2153:
2128:
2124:
2117:
2074:
2070:
2060:
2025:
2021:
2011:
1968:
1964:
1954:
1937:
1931:
1914:
1908:
1873:
1869:
1859:
1845:
1825:
1818:
1788:(1–2): 1–8.
1785:
1781:
1775:
1766:
1757:
1748:
1739:
1730:
1721:
1638:
1635:Interactions
1624:Preeclampsia
1600:hypoglycemia
1585:
1576:
1559:neurogenesis
1551:
1547:progesterone
1543:
1528:
1521:
1512:
1507:
1502:
1498:
1493:
1479:
1470:The protein
1469:
1462:
1458:
1450:
1429:
1427:
1414:somatotropin
1397:
1393:
1392:
1205:NP_001302418
1201:NP_001302417
1197:NP_001116209
1193:NP_001116208
1190:
1172:NP_001278791
1168:NP_001278790
1164:NP_001121070
1160:NP_001007140
1153:
1130:NM_001315489
1126:NM_001315488
1118:NM_001122737
1114:NM_001122736
1111:
1093:NM_001291861
1089:NM_001127598
1085:NM_001007139
1077:NM_001291862
1074:
1050:
1031:
1005:
986:
960:
941:
921:
916:
727:ossification
409:
402:
368:142,220,553
355:142,204,503
129:External IDs
72:
6938:Oncomodulin
6802:Aflibercept
6792:Ranibizumab
6787:Ramucirumab
6777:Bevacizumab
6769:Antibodies:
6727:Regorafenib
6667:Altiratinib
6580:ONO-5390556
6550:Entrectinib
6525:Altiratinib
6479:ONO-5390556
6449:Entrectinib
6424:Altiratinib
6210:Frunevetmab
6182:Antibodies:
6159:ONO-5390556
6124:Entrectinib
6099:Altiratinib
6054:Tavilermide
5949:Quizartinib
5888:SCF (c-Kit)
5712:Ramucirumab
5704:Antibodies:
5677:Quizartinib
5627:Avapritinib
5590:Becaplermin
5526:Frunevetmab
5505:Antibodies:
5408:Trofinetide
5339:Dusigitumab
5336:Antibodies:
5291:Robatumumab
5281:Figitumumab
5276:Dalotuzumab
5271:Cixutumumab
5263:Antibodies:
5155:Rilotumumab
5150:Onartuzumab
5145:Flanvotumab
5132:Antibodies:
5100:PF-04217903
5030:Altiratinib
4993:HGF (c-Met)
4896:Antibodies:
4801:Antibodies:
4523:Duligotumab
4520:Antibodies:
4434:Trastuzumab
4424:Ertumaxomab
4421:Antibodies:
4392:Zalutumumab
4387:Panitumumab
4382:Nimotuzumab
4377:Necitumumab
4367:Imgatuzumab
4344:Antibodies:
4327:Osimertinib
4292:Dacomitinib
4187:Dapiclermin
4146:Antibodies:
4129:Altiratinib
3968:Osteocalcin
3945:Adiponectin
3772:Thymosin α1
3547:Parathyroid
3447:Aldosterone
3350:Vasopressin
2707:PDB gallery
1649:transferrin
1292:Identifiers
517:neural tube
439:sural nerve
107:Identifiers
6994:Categories
6757:Vandetanib
6722:Rebastinib
6717:Pegaptanib
6707:Nintedanib
6697:Lenvatinib
6662:Agerafenib
6615:Ripretinib
6540:CH-7057288
6439:CH-7057288
6304:7,8,3'-THF
6299:7,8,2'-THF
6225:Ranevetmab
6215:Fulranumab
6169:Rebastinib
6114:CH-7057288
6029:Cenegermin
5914:Agerafenib
5874:Agerafenib
5855:Vandetanib
5824:Vandetanib
5793:Vandetanib
5762:Vandetanib
5707:Olaratumab
5682:Ripretinib
5662:Nintedanib
5647:Lenvatinib
5637:Crenolanib
5622:Agerafenib
5541:Ranevetmab
5531:Fulranumab
5448:Cenegermin
5422:LNGF (p75)
5344:Xentuzumab
5306:Xentuzumab
5251:NVP-AEW541
5246:NVP-ADW742
5241:Linsitinib
5236:BMS-754807
5221:Mecasermin
5120:Tivantinib
5110:PHA-665752
5105:PF-2341066
5075:Golvatinib
5065:Crizotinib
5060:Capmatinib
5050:BMS-777607
5045:Amuvatinib
4921:Ersofermin
4884:Sprifermin
4840:Ersofermin
4789:Sprifermin
4779:Repifermin
4774:Palifermin
4707:Ersofermin
4686:Velafermin
4671:Repifermin
4624:Ersofermin
4543:ErbB4/HER4
4528:Patritumab
4489:ErbB3/HER3
4469:Mubritinib
4429:Pertuzumab
4402:ErbB2/HER2
4332:Vandetanib
4287:Canertinib
4282:Brigatinib
4277:Agerafenib
4257:Nepidermin
4252:Murodermin
4242:Epiregulin
4197:EGF (ErbB)
4155:Nesvacumab
4149:Evinacumab
4139:Rebastinib
4080:modulators
3996:Calcitriol
3882:Peptide YY
3532:Calcitonin
3484:Adrenaline
3413:Lipotropin
3408:Endorphins
3217:Hepatocyte
2777:Fibroblast
2071:Biochem. J
1716:, May 2017
1695:, May 2017
1672:References
1598:, causing
1510:promoter.
1476:expression
1345:structures
413:(ortholog)
267:2,158,391
254:2,129,112
150:HomoloGene
6782:Icrucumab
6762:WHI-P 154
6752:Tivozanib
6747:Toceranib
6742:Sunitinib
6737:Sorafenib
6732:Semaxanib
6712:Pazopanib
6702:Motesanib
6692:Lapatinib
6682:Cediranib
6620:Telbermin
6607:Agonists:
6555:GZ-389988
6535:CE-245677
6502:Agonists:
6454:GZ-389988
6434:CE-245677
6334:Diosmetin
6271:Agonists:
6237:Aptamers:
6230:Tanezumab
6205:Fasinumab
6149:Milciclib
6129:GZ-389988
6109:CE-245677
6011:Agonists:
5964:Toceranib
5959:Sunitinib
5954:Sorafenib
5944:Pazopanib
5939:Nilotinib
5934:Masitinib
5924:Dasatinib
5896:Agonists:
5842:Agonists:
5811:Agonists:
5780:Agonists:
5752:Liatermin
5744:Agonists:
5727:RET (GFL)
5717:Tovetumab
5697:Toceranib
5692:Sorafenib
5687:Sunitinib
5672:Radotinib
5667:Pazopanib
5657:Motesanib
5652:Masitinib
5587:Agonists:
5553:Aptamers:
5546:Tanezumab
5521:Fasinumab
5430:Agonists:
5286:Ganitumab
5206:IGF-1 LR3
5125:Volitinib
5080:INCB28060
5070:Foretinib
4976:Agonists:
4960:Trafermin
4918:Agonists:
4899:Burosumab
4889:Trafermin
4837:Agonists:
4804:Aprutumab
4794:Trafermin
4756:10 (KGF2)
4704:Agonists:
4681:Trafermin
4661:10 (KGF2)
4621:Agonists:
4551:Agonists:
4497:Agonists:
4479:Tucatinib
4474:Neratinib
4464:Lapatinib
4372:Matuzumab
4362:Futuximab
4347:Cetuximab
4337:WHI-P 154
4322:Neratinib
4317:Lapatinib
4307:Grandinin
4302:Gefitinib
4297:Erlotinib
4174:Agonists:
4134:CE-245677
4096:Agonists:
3767:Thymosins
3728:Melatonin
3610:Estradiol
3457:Cortisone
3383:Prolactin
3280:pituitary
3267:Endocrine
2188:252458335
1524:gestation
1323:IPR013576
1209:NP_034644
1156:NP_000603
1122:NM_010514
1081:NM_000612
907:Orthologs
158:GeneCards
6964:instead)
6953:Renalase
6914:instead)
6885:instead)
6832:instead)
6672:Axitinib
6641:D (FIGF)
6585:PLX-7486
6575:ONO-4474
6530:AZD-6918
6484:PLX-7486
6474:ONO-4474
6429:AZD-6918
6411:Ligands:
6329:Deprenyl
6289:7,3'-DHF
6220:MEDI-578
6200:ASP-6294
6164:PLX-7486
6154:ONO-4474
6104:AZD-6918
6064:ALE-0540
5985:instead.
5929:Imatinib
5919:Axitinib
5899:Ancestim
5864:Unsorted
5642:Imatinib
5632:Axitinib
5536:MEDI-578
5516:ASP-6294
5483:ALE-0540
5325:Agonists
5266:AVE-1642
5192:Agonists
5115:SU-11274
5001:Agonists
4979:FGF15/19
4969:Unsorted
4934:2 (bFGF)
4853:2 (bFGF)
4720:2 (bFGF)
4637:2 (bFGF)
4459:Afatinib
4410:Agonists
4312:Icotinib
4272:Afatinib
4218:Agonists
3960:Skeleton
3950:Resistin
3849:Secretin
3831:Duodenum
3789:Thymulin
3690:Glucagon
3682:Pancreas
3663:Estrogen
3645:Placenta
3452:Cortisol
3345:Oxytocin
3307:Dopamine
3259:Hormones
2929:FGF15/19
2790:ligands:
2644:16612114
2619:15797461
2584:12700030
2395:11600567
2354:22895295
2346:11749962
2274:23844573
2223:17409923
2180:36459047
2145:27488745
2109:39228039
2101:11716772
2052:21873981
2003:21270887
1900:10207053
1810:39228039
1712:–
1691:–
1655:See also
1641:interact
1518:Function
1488:bind to
1402:hormones
1362:RCSB PDB
1318:InterPro
1257:Wikidata
886:Sources:
509:placenta
501:yolk sac
435:placenta
6841:Ephrins
6545:DS-6051
6444:DS-6051
6349:LM22A-4
6339:DMAQ-B1
6294:7,8-DHF
6274:3,7-DHF
6243:RBM-004
6188:GBR-900
6119:DS-6051
6089:VM-902A
5559:RBM-004
5256:OSl-906
5216:Insulin
5095:MK-2461
5040:AMG-458
4177:Axokine
3854:Motilin
3821:Ghrelin
3816:Gastrin
3808:Stomach
3695:Insulin
3630:Relaxin
3625:Inhibin
3620:Activin
3592:Inhibin
3501:Thyroid
3104:Relaxin
3043:Insulin
2652:1030630
2549:9972281
2516:9722981
2477:9446566
2436:9497324
2265:3723441
2248:: 472.
2092:1222244
2043:3209781
1994:3908455
1973:Bibcode
1802:9813220
1769:. NCBI.
1714:Ensembl
1693:Ensembl
1614:in the
1573:Preptin
1410:peptide
1406:insulin
1311:PF08365
1019:UniProt
974:Ensembl
913:Species
892:QuickGO
388:pattern
246:11p15.5
114:Aliases
6811:Others
6505:BNN-20
6394:ANA-12
6319:BNN-20
6039:DHEA-S
6024:BNN-27
6019:BNN-20
5458:DHEA-S
5443:BNN-27
5438:BNN-20
5354:Others
4559:Epigen
4237:Epigen
3978:Kidney
3940:Leptin
3899:/other
3759:Thymus
3700:Amylin
3574:Testis
3467:DHEA-S
3269:glands
3191:VEGF-D
3186:VEGF-C
3181:VEGF-B
3176:VEGF-A
2985:HB-EGF
2916:(FHF4)
2910:(FHF2)
2904:(FHF1)
2898:(FHF3)
2673:(MeSH)
2650:
2642:
2617:
2607:
2582:
2547:
2514:
2475:
2434:
2393:
2352:
2344:
2272:
2262:
2221:
2186:
2178:
2143:
2107:
2099:
2089:
2050:
2040:
2001:
1991:
1965:Nature
1945:
1922:
1898:
1888:
1833:
1808:
1800:
1645:IGFBP3
1612:tumors
1592:tumors
1555:IGFBP7
1553:IGF-2/
1455:allele
1377:PDBsum
1351:
1341:
1300:IGF2_C
1297:Symbol
1243:search
1241:PubMed
1052:P09535
1033:P01344
929:Entrez
559:BioGPS
138:147470
6960:(see
6910:(see
6881:(see
6828:(see
6560:K252a
6459:K252a
6134:K252a
6074:FX007
5834:GFRα4
5803:GFRα3
5772:GFRα2
5736:GFRα1
5364:IGFBP
5317:IGF-2
5296:R1507
5184:IGF-1
5090:K252a
4910:FGFR4
4829:FGFR3
4696:FGFR2
4613:FGFR1
4011:Heart
3986:Renin
3916:IGF-2
3911:IGF-1
3897:Liver
3887:GLP-1
3869:Ileum
3751:Other
3635:GnSAF
3602:Ovary
3212:Nerve
3205:Other
3158:PDGFD
3153:PDGFC
3148:PDGFB
3143:PDGFA
3099:INSL6
3094:INSL5
3089:INSL4
3084:INSL3
3018:TGFβ3
3013:TGFβ2
3008:TGFβ1
2953:FGF23
2948:FGF21
2943:FGF19
2938:FGF15
2914:FGF14
2908:FGF13
2902:FGF12
2896:FGF11
2876:FGF20
2872:FGF16
2863:FGF18
2859:FGF17
2850:FGF22
2846:FGF10
2648:S2CID
2350:S2CID
2184:S2CID
2105:S2CID
1891:84122
1806:S2CID
1643:with
1606:is a
1590:cell
1588:islet
1398:IGF-2
962:16002
922:Mouse
917:Human
888:Amigo
411:Mouse
404:Human
351:Start
286:Mouse
250:Start
183:Human
146:96434
6962:here
6912:here
6883:here
6830:here
6625:VEGF
6599:VEGF
6515:NT-3
6510:DHEA
6494:TrkC
6414:DHEA
6384:TDP6
6364:NT-4
6359:NT-3
6344:HIOC
6314:BDNF
6263:TrkB
6034:DHEA
6003:TrkA
5983:here
5981:See
5974:TGFβ
5579:PDGF
5473:NT-4
5468:NT-3
5453:DHEA
5433:BDNF
4182:CNTF
4166:CNTF
3462:DHEA
3398:ACTH
3393:CLIP
3388:POMC
3317:GHRH
3297:GnRH
3062:IGF2
3057:IGF1
3045:and
3003:TGFβ
2975:TGFα
2868:FGF9
2855:FGF8
2842:FGF7
2820:FGF6
2816:FGF4
2812:FGF3
2807:FGF5
2803:FGF2
2799:FGF1
2725:1igl
2640:PMID
2615:PMID
2605:ISBN
2580:PMID
2545:PMID
2512:PMID
2473:PMID
2432:PMID
2391:PMID
2342:PMID
2270:PMID
2219:PMID
2176:PMID
2141:PMID
2097:PMID
2048:PMID
1999:PMID
1943:ISBN
1920:ISBN
1896:PMID
1831:ISBN
1798:PMID
1767:MeSH
1647:and
1594:and
1567:PTSD
1563:fear
1508:IGF2
1503:IGF2
1499:IGF2
1494:IGF2
1490:CTCF
1472:CTCF
1461:and
1459:IGF2
1451:IGF2
1435:gene
1431:IGF2
1370:PDBj
1366:PDBe
1349:ECOD
1339:Pfam
1306:Pfam
943:3481
394:Bgee
342:Band
303:Chr.
241:Band
200:Chr.
162:IGF2
134:OMIM
121:IGF2
91:3E4Z
87:2V5P
83:2L29
79:1IGL
75:3KR3
56:RCSB
53:PDBe
22:IGF2
6379:R13
6049:NGF
5994:Trk
5463:NGF
5175:IGF
5035:AM7
4926:FGF
4845:FGF
4746:),
4744:KGF
4712:FGF
4629:FGF
4604:FGF
4206:EGF
4029:BNP
4024:ANP
3991:EPO
3859:VIP
3844:GIP
3839:CCK
3658:HPL
3653:hCG
3587:AMH
3555:PTH
3403:MSH
3378:TSH
3368:FSH
3327:MCH
3312:CRH
3302:TRH
3196:PGF
2980:EGF
2832:KGF
2632:doi
2597:doi
2570:doi
2537:doi
2533:121
2504:doi
2463:doi
2459:273
2422:doi
2418:273
2381:doi
2332:doi
2328:509
2298:doi
2260:PMC
2250:doi
2211:doi
2168:doi
2164:323
2133:doi
2087:PMC
2079:doi
2075:360
2038:PMC
2030:doi
1989:PMC
1981:doi
1969:469
1886:PMC
1878:doi
1790:doi
1786:810
1481:H19
1464:H19
1357:PDB
364:End
263:End
166:OMA
154:510
142:MGI
46:PDB
6996::
6873:B3
6871:,
6869:B2
6867:,
6865:B1
6863:,
6861:A5
6859:,
6857:A4
6855:,
6853:A3
6851:,
6849:A2
6847:,
6845:A1
6639:,
6635:,
6631:,
6374:R7
6190:;
5609:,
5605:,
5601:,
5390:,
5386:,
5382:,
5378:,
5374:,
5370:,
5327::
5194::
5003::
4954:19
4952:,
4948:,
4944:,
4940:,
4936:,
4932:,
4873:23
4871:,
4869:18
4867:,
4863:,
4859:,
4855:,
4851:,
4768:22
4766:,
4764:18
4762:,
4760:17
4758:,
4754:,
4750:,
4738:,
4734:,
4730:,
4726:,
4722:,
4718:,
4665:20
4663:,
4659:,
4655:,
4651:,
4647:,
4643:,
4639:,
4635:,
4587:,
4583:,
4579:,
4575:,
4510:,
4506:,
4412::
4220::
3420:GH
3373:LH
2646:.
2638:.
2613:.
2603:.
2578:.
2564:.
2560:.
2543:.
2531:.
2527:.
2510:.
2500:30
2498:.
2471:.
2457:.
2453:.
2430:.
2416:.
2412:.
2389:.
2377:86
2375:.
2371:.
2348:.
2340:.
2326:.
2322:.
2310:^
2294:28
2292:.
2268:.
2258:.
2246:14
2244:.
2240:.
2217:.
2205:.
2182:.
2174:.
2162:.
2139:.
2129:14
2127:.
2103:.
2095:.
2085:.
2073:.
2069:.
2046:.
2036:.
2026:30
2024:.
2020:.
1997:.
1987:.
1979:.
1967:.
1963:.
1894:.
1884:.
1874:19
1872:.
1868:.
1804:.
1796:.
1784:.
1765:.
1747:.
1729:.
1700:^
1679:^
1651:.
1602:.
1569:.
1526:.
1368:;
1364:;
1347:/
890:/
370:bp
357:bp
269:bp
256:bp
164:;
160::
156:;
152::
148:;
144::
140:;
136::
89:,
85:,
81:,
77:,
6906:/
6875:)
6843:(
6643:)
6637:C
6633:B
6629:A
6627:(
6176:)
5613:)
5611:D
5607:C
5603:B
5599:A
5597:(
5394:)
5392:7
5388:6
5384:5
5380:4
5376:3
5372:2
5368:1
5366:(
4956:)
4950:9
4946:8
4942:6
4938:4
4930:1
4928:(
4875:)
4865:9
4861:8
4857:4
4849:1
4847:(
4770:)
4752:9
4748:8
4742:(
4740:7
4736:6
4732:5
4728:4
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