327:
304:
226:
201:
4099:
578:
4114:
333:
232:
42:
1368:, has different effects on the protein, but most of these effects include cellular re-localization, conformational and steric changes. These processes lead to decrease in Tyrosine phosphorylation by insulin receptors and diminished PI3K recruitment. Altogether, these mechanisms stimulate IRS-1 degradation and insulin resistance. Other inhibitory pathways include
1577:(HCC). In rat model, IRS-1 focal overexpression is associated with early events of hepatocarcinogenesis. During progression of preneoplastic foci into hepatocellular carcinomas expression of IRS-1 gradually decreases, which is characterises a metabolic shift heading towards malignant neoplastic phenotype. Transgenic mice, co-expressing IRS-1 and
1714:. Frequency of lung metastasis in IRS-1 deficient tumor is elevated opposing to IRS-2 deficient tumor, where it is decreased. Basically, IRS-2 has a positive impact on metastasis of breast cancer whereas a stronger metastatic potential is observed when IRS-1 is down-regulated. IRS-1 is strongly expressed in
1284:. This phosphorylation is absent in tissues lacking IRS-1. The cascade is followed by glucose uptake. Formation of the Grb-2/Sos complex, also known as the RAS guanine nucleotide exchange factor complex, results in ERK1/2 activation. IRS-1 signal transduction may be inhibited by SHP2 in some tissues.
1668:
is able to reduce IRS-1 transcript level, thereby reducing protein expression in MCF-7 ER+ cells. Reduction of IRS-1 leads to decreased survival of these cells. siRNA treatment effects are additive to effects of TAM treatment. IGFRs and estrogen coaction facilitates growth in different breast cancer
1312:
An alternative multi-site phosphorylation of Serine/Threonine in IRS-1 regulates insulin signaling positively and negatively. C-terminal region contains most of the phosphorylation sites of the protein. The C-terminal tail is not structured, therefore the mechanisms of regulation of IRS-1 by
68:
1669:
cell lines, however amplification of IGF1R signalling can abrogate need of estrogen for transformation and growth of MCF-7 cells. IRS-1 overexpression in breast cancer cells decreased estrogen requirements. This decrease is dependent on IRS-1 levels in the cells.
3635:
Cesarone G, Edupuganti OP, Chen CP, Wickstrom E (2007-12-01). "Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1".
2641:"Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation"
2015:
Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ (March 2008).
3566:
Hellawell GO, Turner GD, Davies DR, Poulsom R, Brewster SF, Macaulay VM (May 2002). "Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease".
1685:
and positively regulates IRS-1 mRNA production. Decreased anchorage- dependent/independent cell growth and initiation of cell death under low growth factor and estrogen conditions are observed in MCF-7 cells with down-regulated IRS-1.
1542:(min/+) mutated mice shows increased irradiation-induced apoptosis in crypt. Deficiency in IRS-1 - partial (+/-) or absolute (-/-) - in Apc (min/+) mice demonstrates reduced amount of tumors comparing to IRS-1 (+/+)/ Apc (min/+) mice.
1493:
IRS-1, as a signalling adapter protein, is able to integrate different signalling cascades, which indicates its possible role in cancer progression. IRS-1 protein is known to be involved in various types of cancer, including
2302:
Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorensen PH (August 2002). "ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation".
1561:
is shown to degrade IRS-1 by gaining access to endosomal compartment of carcinoma cell. IRS-1 degradation induces cell proliferation in mouse and human adenocarcinomas. Ablation of IRS-1 alters downstream signalling through
1628:
of metastatic prostate cancer goes along with down-regulation of IRS-1 and significant reduction of PTEN in 3 out of 12 cases. Most of the tumors still express IRS-1 and IGF1R during progression of the metastatic disease.
340:
239:
3671:
Surmacz E, Burgaud JL (November 1995). "Overexpression of insulin receptor substrate 1 (IRS-1) in the human breast cancer cell line MCF-7 induces loss of estrogen requirements for growth and transformation".
1830:
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF (July 1991). "Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein".
1607:
independent mechanism, when IRS-1 is ectopically expressed in the cells. These effects are mediated by PI3K. Uncanonical phosphorylation of Serine 612 by PI3K of IRS-1 protein is due to hyper-activation of
3067:"Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein"
1317:
causes insulin resistance and multi-site S/T phosphorylation, which results in block of interaction between IRS-1 and juxtamembrane domain peptide, thus converting IRS-1 into an inactive state.
3294:
Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD (February 2010).
3699:
Mauro L, Salerno M, Panno ML, Bellizzi D, Sisci D, Miglietta A, Surmacz E, AndΓ² S (November 2001). "Estradiol increases IRS-1 gene expression and insulin signaling in breast cancer cells".
1698:
mice overexpressing IRS-1 develop metastatic breast cancer. The tumors demonstrate squamous differentiation which is associated with Ξ²-catenin pathway. IRS-1 interacts with Ξ²-catenin both
1392:. This metabolite if present in high amounts leads to O-GlcNAc protein modifications. IRS-1 can undergo this modification, which results in its phosphorylation and functional suppression.
3523:
Reiss K, Wang JY, Romano G, Tu X, Peruzzi F, Baserga R (January 2001). "Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells".
1589:
that results in HCC development. Expressed alone, IRS-1 and HBx are not sufficient to induce neoplastic alterations in the liver, though their paired expression switches on IN/IRS-1/
1268:
pathways. Tyrosine phosphorylation of IRS-1 by insulin receptor (IR) introduces multiple binding sites for proteins bearing SH2 homology domain, such as PI3K, Grb-2/Sos complex and
3949:
Bezerra RM, Chadid TT, Altemani CM, Sales TS, Menezes R, Soares MC, Saad ST, Saad MJ (February 2004). "Lack of Arg972 polymorphism in the IRS1 gene in
ParakanΓ£ Brazilian Indians".
3863:"IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors"
3232:
Esposito DL, Aru F, Lattanzio R, Morgano A, Abbondanza M, Malekzadeh R, Bishehsari F, Valanzano R, Russo A, Piantelli M, Moschetta A, Lotti LV, Mariani-Costantini R (2012-04-27).
2474:"Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system"
4098:
2813:"An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events"
2433:"Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786"
1652:, ectopic expression of PTEN in MCF-7 suppresses IRS-1/Grb-2/Sos complex formation due to differential phosphorylation of IRS-1. Overexpression of IRS-1 has been linked to
1538:, InsRΞ² and IGF1R. IRS-1 promotes CRC metastasis to the liver. Decreased apoptosis of crypt stem cells is associated with colon cancer risk. Reduced expression of IRS-1 in
1616:Ξ±5Ξ²1, activating an alternative signalling cascade. This cascade results in decreased cell motility opposing to IGF-1 - dependent mechanism. Loss of IRS-1 expression and
3596:"PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model"
1301:. Multiple tyrosine residues of IRS-1 itself are then phosphorylated by these receptors. This enables IRS-1 to activate several signalling pathways, including the
3734:
Nolan MK, Jankowska L, Prisco M, Xu S, Guvakova MA, Surmacz E (September 1997). "Differential roles of IRS-1 and SHC signaling pathways in breast cancer cells".
1690:
is underexpressed in breast cancer cells. mir126 targets IRS-1 at transcriptional level and inhibits transition from G1/G0 phase to S phase during cell cycle in
1376:
of IRS-1. SOCS proteins act by binding to IR and by interfering with IR phosphorylation of IRS-1, therefore attenuating insulin signaling. They can also bind to
2903:"Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins"
1530:(APC) - mutated cells, it is also needed for transformation in ectopically expressing oncogenic Ξ²-catenin cells. IRS-1 dominant-negative mutant functions as
3386:"Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9"
931:
912:
162:
2731:"Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers"
2252:"The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling"
2201:
Ueno H, Kondo E, Yamamoto-Honda R, Tobe K, Nakamoto T, Sasaki K, Mitani K, Furusaka A, Tanaka T, Tsujimoto Y, Kadowaki T, Hirai H (February 2000).
2690:"The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)"
2639:
Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, Narazaki M, Okumura K, Saitoh H, Nakagawa R, Uchiyama Y, Akira S, Kishimoto T (January 2001).
2600:"Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases"
1534:, whereas ectopic IRS-1 stimulates oncogenic transformation. IRS-1 is upregulated in colorectal cancers (CRC) with elevated levels of Ξ²-catenin,
3149:"14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner"
2114:
Gual P, Le
Marchand-Brustel Y, Tanti JF (January 2005). "Positive and negative regulation of insulin signaling through IRS-1 phosphorylation".
1302:
1812:
3812:
Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV (December 2006).
1794:
2065:
Xu X, Sarikas A, Dias-Santagata DC, Dolios G, Lafontant PJ, Tsai SC, Zhu W, Nakajima H, Nakajima HO, Field LJ, Wang R, Pan ZQ (May 2008).
3747:
1648:
pathway is inhibited by phosphatase activity of PTEN. PTEN does not have effect on IRS-1 independent MAPK activation. When treated with
4113:
1276:, which, in turn, recruits Akt kinase. Further, Akt kinase is activated via phosphorylation of its T308 residue and analogous sites in
1273:
1131:
1724:
when IRS-2 is elevated in invasive tumors. Increased IRS-1 makes MCF-7 cells susceptible to specific chemotherapeutic agents, such as
3435:"Overexpression of insulin receptor substrate-1 emerges early in hepatocarcinogenesis and elicits preneoplastic hepatic glycogenosis"
2854:"Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation"
2392:"Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action"
1138:
2203:"Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function"
1710:
play distinct roles in breast cancer progression and metastasis. Overexpression of either one is sufficient to cause tumorogenesis
1567:
1389:
1262:
3777:
Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ, Ma D (December 2008). "The cell growth suppressor, mir-126, targets IRS-1".
4078:
1515:
1427:
1250:
1913:"Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2"
1777:
4142:
65:
1961:
1756:
2559:"Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor"
1369:
3476:"Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver"
326:
1590:
1265:
2811:
Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL (May 2002).
2250:
Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Backer JM, Ullrich A, White MF (May 1993).
1781:
1760:
303:
3814:"Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2"
3026:"The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling"
2772:"Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes"
1624:
studies of IRS-1 involvement in prostate cancer show ambiguous results. Down-regulation of IGF1R in bone marrow
1736:. Therefore, IRS-1 can be a good pointer of specific drug therapies effectiveness for breast cancer treatment.
1212:
976:
2018:"Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice"
2515:"Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10"
957:
3234:"The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer"
2154:"Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility"
1604:
1526:-Ξ²-catenin complexes directly regulate IRS-1. IRS-1 is required for maintenance of neoplasmic phenotype in
1365:
225:
200:
142:
4023:"Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2"
3384:
Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, McNaughton KK, Lund PK (January 2008).
3190:"Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2"
2944:"Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)"
1401:
1314:
3108:"Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor"
1380:, causing a subsequent decrease in IRS-1 tyrosine phosphorylation. During insulin resistance induced by
2067:"The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation"
1539:
1527:
339:
238:
2729:
Hadari YR, Tzahar E, Nadiv O, Rothenberg P, Roberts CT, LeRoith D, Yarden Y, Zick Y (September 1992).
4071:
2985:"The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp"
1609:
1563:
1254:
332:
231:
1960:
Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L (April 2001).
129:
2598:
Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995).
1715:
1632:
IRS-1 has a functional role in breast cancer progression and metastasis. Overexpression of PTEN in
1574:
150:
4107:: IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
1215:
ca. 40 residues downstream of this, followed by a poorly conserved C-terminus tail. Together with
1114:
1093:
1067:
1046:
3474:
Longato L, de la Monte S, Kuzushita N, Horimoto M, Rogers AB, Slagle BL, Wands JR (June 2009).
1665:
1653:
1594:
1531:
1294:
17:
4064:
3245:
1973:
1840:
214:
1962:"Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein"
1233:, whose disruption extends the median lifespan of flies up to 48%. Similarly, Irs1 mutant
1207:. It is a 180 kDa protein with amino acid sequence of 1242 residues. It contains a single
170:
8:
1682:
1678:
1558:
1208:
3249:
1977:
1844:
3974:
3887:
3862:
3838:
3813:
3759:
3548:
3500:
3475:
3451:
3434:
3410:
3385:
3320:
3295:
3268:
3233:
2878:
2853:
2770:
Gual P, Gonzalez T, GrΓ©meaux T, Barres R, Le
Marchand-Brustel Y, Tanti JF (July 2003).
2665:
2640:
2328:
2267:
2091:
2066:
2047:
1997:
1937:
1912:
1864:
1673:
enhances expression of IRS-1 and activity of ERK1/2 and PI3K/Akt pathways in MCF-7 and
174:
3001:
2984:
2747:
2730:
2276:
2251:
1883:"IRS1 - Insulin receptor substrate 1 - Homo sapiens (Human) - IRS1 gene & protein"
1660:(TAM) inhibits IRS-1 function, therefore suppressing IRS-1/PI3K signalling cascade in
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
715:
710:
705:
700:
695:
690:
685:
669:
664:
659:
654:
649:
644:
639:
629:
624:
619:
4044:
4009:
3966:
3937:
3892:
3843:
3794:
3751:
3716:
3681:
3653:
3617:
3576:
3540:
3505:
3456:
3415:
3366:
3325:
3273:
3211:
3170:
3129:
3088:
3047:
3006:
2965:
2924:
2883:
2834:
2793:
2752:
2711:
2670:
2621:
2580:
2536:
2495:
2454:
2413:
2369:
2364:
2347:
2320:
2281:
2232:
2227:
2202:
2183:
2178:
2153:
2131:
2096:
2039:
1989:
1942:
1856:
1661:
1495:
122:
58:
3552:
2051:
2001:
4034:
3999:
3978:
3958:
3927:
3882:
3874:
3833:
3825:
3786:
3763:
3743:
3708:
3645:
3607:
3532:
3495:
3487:
3446:
3405:
3397:
3356:
3315:
3307:
3263:
3253:
3201:
3160:
3119:
3078:
3037:
2996:
2955:
2914:
2901:
Mothe I, Delahaye L, Filloux C, Pons S, White MF, Van
Obberghen E (December 1997).
2873:
2865:
2824:
2783:
2742:
2701:
2660:
2652:
2611:
2570:
2526:
2485:
2444:
2403:
2359:
2332:
2312:
2271:
2263:
2222:
2214:
2173:
2165:
2123:
2086:
2078:
2029:
1981:
1932:
1924:
1868:
1848:
1511:
1421:
1349:
1306:
1246:
419:
350:
294:
249:
1570:(PDGFR). Therefore, IRS-1 acts as major regulator of PI3K in lung adenocarcinoma.
1360:. Different Serine phosphorylation of IRS-1, caused by various molecules, such as
1297:
binding, induces the cytoplasmic binding of IRS-1 to these receptors, through its
154:
3878:
3296:"Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth"
3258:
2471:
2152:
MaΓ±es S, Mira E, GΓ³mez-Mouton C, Zhao ZJ, Lacalle RA, MartΓnez-A C (April 1999).
2127:
2082:
1503:
1290:
394:
178:
2942:
Lebrun P, Mothe-Satney I, Delahaye L, Van
Obberghen E, Baron V (November 1998).
2869:
2472:
Tartare-Deckert S, Sawka-Verhelle D, Murdaca J, Van
Obberghen E (October 1995).
1817:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1799:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1636:
epithelial breast cancer cells inhibits cell growth by inhibiting MAPK pathway.
3790:
2430:
1546:
1523:
1439:
1433:
1333:
1245:
Insulin receptor substrate 1 plays a key role in transmitting signals from the
495:
2829:
2812:
2531:
2514:
2390:
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF (January 2002).
1928:
1328:(growth promoting) pathways: mice deficient of IRS1 have only a mild diabetic
4136:
3165:
3148:
3042:
3025:
2960:
2943:
2616:
2599:
2490:
2473:
2431:
Sawka-Verhelle D, Tartare-Deckert S, White MF, Van
Obberghen E (March 1996).
1691:
1507:
1381:
606:
3932:
3915:
3124:
3107:
2919:
2902:
2706:
2689:
2575:
2558:
2449:
2432:
1985:
1603:
prostate cancer cells increase cell adhesion and diminish cell motility via
634:
555:
433:
4048:
4013:
3970:
3941:
3896:
3847:
3798:
3748:
10.1002/(sici)1097-0215(19970904)72:5<828::aid-ijc20>3.0.co;2-3
3720:
3712:
3657:
3621:
3612:
3595:
3580:
3544:
3536:
3509:
3419:
3370:
3329:
3277:
3215:
3133:
3092:
3083:
3066:
2887:
2838:
2797:
2788:
2771:
2715:
2674:
2417:
2408:
2391:
2324:
2316:
2236:
2187:
2135:
2100:
2043:
1993:
1946:
1519:
1377:
1234:
577:
412:
191:
3962:
3755:
3685:
3460:
3174:
3051:
3010:
2969:
2928:
2756:
2656:
2625:
2584:
2540:
2499:
2458:
2373:
2346:
Giorgetti-Peraldi S, Peyrade F, Baron V, Van
Obberghen E (December 1995).
2345:
2285:
2169:
2034:
2017:
1860:
1178:
1173:
3829:
3401:
3024:
Myers MG, Mendez R, Shi P, Pierce JH, Rhoads R, White MF (October 1998).
2218:
1882:
1733:
1617:
1578:
1499:
1385:
1021:
1002:
4039:
4022:
4004:
3987:
3361:
3344:
3206:
3189:
3065:
Goldstein BJ, Bittner-Kowalczyk A, White MF, Harbeck M (February 2000).
1237:
experience moderate life extension and delayed age-related pathologies.
41:
2941:
2513:
Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW (June 1996).
1725:
1695:
1637:
1554:
1361:
1357:
1298:
1225:
311:
208:
158:
3649:
3491:
3064:
99:
95:
91:
87:
3861:
Porter HA, Perry A, Kingsley C, Tran NL, Keegan AD (September 2013).
1852:
1729:
1674:
1670:
1657:
1586:
1550:
1353:
1329:
1321:
1277:
876:
378:
365:
277:
264:
166:
3311:
1557:
have recently been thought to adjust tumor growth and invasiveness.
1553:
overexpression of IRS-1 leads to reduced growth. Tumor infiltrating
3473:
1613:
1373:
1287:
1162:
3988:"Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis"
3345:"Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis"
1687:
1649:
1325:
1197:
988:
943:
861:
857:
1293:
of the insulin receptors or IGF-1 receptors, upon extracellular
146:
3634:
2688:
Aguirre V, Uchida T, Yenush L, Davis R, White MF (March 2000).
2348:"Involvement of Janus kinases in the insulin signaling pathway"
2014:
1625:
1468:
1456:
1451:
1146:
898:
625:
transmembrane receptor protein tyrosine kinase adaptor activity
586:
4056:
2064:
1633:
1600:
1518:(IGF1R) and many other cytokine receptors and is elevated in
1480:
1474:
1445:
1409:
1313:
phosphorylation still remain unclear. It has been shown that
777:
positive regulation of phosphatidylinositol 3-kinase activity
3565:
3383:
3293:
2810:
2556:
2113:
4122:: CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
4021:
Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007).
3231:
3188:
Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007).
2728:
2200:
1707:
1645:
1641:
1462:
1415:
1345:
1281:
1269:
1220:
1216:
1204:
3948:
2769:
2638:
2512:
1344:
The cellular protein levels of IRS-1 are regulated by the
3698:
2557:
Gual P, Baron V, Lequoy V, Van Obberghen E (March 1998).
2301:
2249:
2151:
1582:
1535:
1258:
807:
positive regulation of insulin receptor signaling pathway
787:
negative regulation of insulin receptor signaling pathway
2900:
2687:
1959:
402:
3860:
3106:
Ravichandran LV, Chen H, Li Y, Quon MJ (October 2001).
2982:
1829:
655:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
3733:
3432:
3146:
3105:
2983:
KuhnΓ© MR, Pawson T, Lienhard GE, Feng GS (June 1993).
2389:
1656:
resistance and hormone independence in breast cancer.
2597:
1585:) protein, demonstrate higher rate of hepatocellular
1272:. PI3K, involved in interaction with IRS-1, produces
832:
phosphatidylinositol-3-phosphate biosynthetic process
742:
insulin-like growth factor receptor signaling pathway
567:
3023:
1566:(PI3K), causing an increased interaction of it with
792:
positive regulation of cell population proliferation
752:
positive regulation of glycogen biosynthetic process
4020:
3811:
3779:
Biochemical and Biophysical Research Communications
3701:
Biochemical and Biophysical Research Communications
3187:
1620:mutations in LNCaP cells could promote metastasis.
1320:IRS-1 plays important biological function for both
827:
phosphatidylinositol phosphate biosynthetic process
3913:
3433:Nehrbass D, Klimek F, Bannasch P (February 1998).
1773:
1771:
1769:
1752:
1750:
1748:
1332:, but a pronounced growth impairment, i.e., IRS-1
3594:Weng LP, Smith WM, Brown JL, Eng C (March 2001).
3593:
3522:
1597:/Ξ²-catenin cascades, causing HCC transformation.
842:positive regulation of protein kinase B signaling
349:
248:
4134:
3147:Craparo A, Freund R, Gustafson TA (April 1997).
767:positive regulation of glucose metabolic process
732:positive regulation of fatty acid beta-oxidation
2385:
2383:
2297:
2295:
2147:
2145:
1766:
1745:
3920:The Journal of Allergy and Clinical Immunology
3776:
3670:
2552:
2550:
1778:GRCm38: Ensembl release 89: ENSMUSG00000055980
4072:
3289:
3287:
1336:only reach 50% of the weight of normal mice.
3985:
3342:
3099:
3058:
2845:
2804:
2763:
2681:
2632:
2380:
2292:
2194:
2142:
2058:
3914:Jiang H, Harris MB, Rothman P (June 2000).
3140:
3017:
2976:
2935:
2894:
2722:
2591:
2547:
2506:
2465:
2424:
2339:
2243:
1757:GRCh38: Ensembl release 89: ENSG00000169047
620:insulin-like growth factor receptor binding
4079:
4065:
3284:
2851:
1910:
1823:
444:Skeletal muscle tissue of rectus abdominis
4038:
4003:
3931:
3886:
3837:
3611:
3499:
3450:
3409:
3360:
3319:
3267:
3257:
3205:
3164:
3123:
3082:
3041:
3000:
2959:
2918:
2877:
2828:
2787:
2746:
2705:
2664:
2615:
2574:
2530:
2489:
2448:
2407:
2363:
2275:
2226:
2177:
2090:
2033:
1936:
1612:B pathway in LNCaP. IRS-1 interacts with
1522:induced cells. Some evidence shows that
1384:, glucose accumulates in tissues as its
837:interleukin-7-mediated signaling pathway
747:negative regulation of insulin secretion
691:intracellular membrane-bounded organelle
660:1-phosphatidylinositol-3-kinase activity
3986:Gibson SL, Ma Z, Shaw LM (March 2007).
3343:Gibson SL, Ma Z, Shaw LM (March 2007).
1568:platelet-derived growth factor receptor
812:phosphatidylinositol-mediated signaling
802:phosphatidylinositol 3-kinase signaling
14:
4135:
3916:"IL-4/IL-13 signaling beyond JAK/STAT"
1664:positive (ER+) MCF-7 cell line. IRS-1
133:, HIRS-1, insulin receptor substrate 1
4060:
3227:
3225:
1573:Some evidence shows role of IRS-1 in
1516:insulin-like growth factor-1 receptor
1251:insulin-like growth factor 1 receptor
797:cellular response to insulin stimulus
737:positive regulation of glucose import
640:phosphatidylinositol 3-kinase binding
354:
315:
310:
253:
212:
207:
2645:The Journal of Experimental Medicine
1906:
1904:
1902:
1211:(PH) domain at the N-terminus and a
3153:The Journal of Biological Chemistry
3071:The Journal of Biological Chemistry
3030:The Journal of Biological Chemistry
2989:The Journal of Biological Chemistry
2948:The Journal of Biological Chemistry
2776:The Journal of Biological Chemistry
2735:The Journal of Biological Chemistry
2694:The Journal of Biological Chemistry
2604:The Journal of Biological Chemistry
2478:The Journal of Biological Chemistry
2437:The Journal of Biological Chemistry
2396:The Journal of Biological Chemistry
1911:Copps KD, White MF (October 2012).
1681:. Estradiol acts directly on IRS-1
1677:cells transfected with mouse IRS-1
1510:. IRS-1 integrates signalling from
1253:(IGF-1) to intracellular pathways
24:
3906:
3222:
2268:10.1002/j.1460-2075.1993.tb05842.x
822:insulin receptor signaling pathway
25:
4154:
3439:The American Journal of Pathology
1899:
1488:
1200:that in humans is encoded by the
4112:
4097:
2852:Xia X, Serrero G (August 1999).
2365:10.1111/j.1432-1033.1995.656_b.x
2352:European Journal of Biochemistry
1404:(also concerted activity) with:
576:
338:
331:
325:
302:
237:
230:
224:
199:
40:
4086:
3854:
3805:
3770:
3736:International Journal of Cancer
3727:
3692:
3664:
3628:
3587:
3559:
3516:
3467:
3426:
3377:
3336:
3181:
2107:
1395:
847:cellular response to fatty acid
665:phosphotyrosine residue binding
452:epithelium of lactiferous gland
3818:Molecular and Cellular Biology
2158:Molecular and Cellular Biology
2008:
1953:
1875:
1805:
1787:
1640:phosphorylation through IRS-1/
587:More reference expression data
556:More reference expression data
13:
1:
3002:10.1016/S0021-9258(19)50220-4
2748:10.1016/S0021-9258(19)37065-6
2207:Molecular Biology of the Cell
1739:
1564:phosphatidylinositol-3 kinase
1339:
542:vestibular sensory epithelium
323:
222:
3879:10.1016/j.canlet.2013.03.030
3259:10.1371/journal.pone.0036190
2128:10.1016/j.biochi.2004.10.019
2083:10.1016/j.molcel.2008.03.009
1356:mediated degradation by the
1191:Insulin receptor substrate 1
7:
4143:Genes on human chromosome 2
1706:. IRS-1 and its homologue
1240:
762:response to peptide hormone
476:stromal cell of endometrium
10:
4159:
3791:10.1016/j.bbrc.2008.09.089
1528:adenomatous polyposis coli
1352:, which targets IRS-1 for
1223:, it is homologous to the
635:signal transducer activity
522:sternocleidomastoid muscle
4092:
2870:10.1042/0264-6021:3410831
2830:10.1007/s00125-002-0798-5
2532:10.1210/mend.10.6.8776723
1929:10.1007/s00125-012-2644-8
1813:"Mouse PubMed Reference:"
1795:"Human PubMed Reference:"
1177:
1172:
1168:
1161:
1145:
1126:
1111:
1107:
1090:
1086:
1079:
1064:
1060:
1043:
1039:
1032:
1019:
1015:
1000:
996:
987:
974:
970:
955:
951:
942:
929:
925:
910:
906:
897:
882:
875:
871:
855:
605:
601:
584:
575:
566:
553:
502:
493:
480:mucosa of urinary bladder
440:
431:
401:
393:
389:
372:
359:
322:
301:
292:
288:
271:
258:
221:
198:
189:
185:
140:
137:
127:
120:
115:
84:
79:
62:
57:
52:
48:
39:
34:
3674:Clinical Cancer Research
3600:Human Molecular Genetics
3166:10.1074/jbc.272.17.11663
3043:10.1074/jbc.273.41.26908
2961:10.1074/jbc.273.48.32244
2617:10.1074/jbc.270.48.28527
2491:10.1074/jbc.270.40.23456
1575:hepatocellular carcinoma
1219:, IRS3 (pseudogene) and
1132:Chr 2: 226.73 β 226.8 Mb
701:insulin receptor complex
670:insulin receptor binding
650:protein kinase C binding
3933:10.1067/mai.2000.107604
3125:10.1210/mend.15.10.0711
3112:Molecular Endocrinology
2920:10.1210/mend.11.13.0029
2907:Molecular Endocrinology
2858:The Biochemical Journal
2707:10.1074/jbc.275.12.9047
2576:10.1210/endo.139.3.5829
2519:Molecular Endocrinology
2450:10.1074/jbc.271.11.5980
1986:10.1126/science.1057991
1400:IRS1 has been shown to
1196:is a signaling adapter
1139:Chr 1: 82.21 β 82.27 Mb
518:vastus lateralis muscle
464:vastus lateralis muscle
29:Protein found in humans
3713:10.1006/bbrc.2001.5815
3638:Bioconjugate Chemistry
3537:10.1038/sj.onc.1204112
3084:10.1074/jbc.275.6.4283
2789:10.1074/jbc.M212273200
2409:10.1074/jbc.M101521200
2317:10.1038/sj.onc.1205669
514:triceps brachii muscle
3963:10.1353/hub.2004.0015
2657:10.1084/jem.193.2.263
2170:10.1128/mcb.19.4.3125
2035:10.1096/fj.07-9261com
3830:10.1128/MCB.00260-06
3613:10.1093/hmg/10.6.605
3402:10.1210/en.2007-0869
2219:10.1091/mbc.11.2.735
1683:regulatory sequences
317:Chromosome 1 (mouse)
215:Chromosome 2 (human)
80:List of PDB id codes
53:Available structures
4040:10.4161/cc.6.6.4035
4005:10.4161/cc.6.6.3987
3926:(6 Pt 1): 1063β70.
3362:10.4161/cc.6.6.3987
3250:2012PLoSO...736190E
3207:10.4161/cc.6.6.4035
1978:2001Sci...292..104C
1845:1991Natur.352...73S
1559:Neutrophil elastase
1209:pleckstrin homology
817:signal transduction
782:response to insulin
757:glucose homeostasis
356:1 C5|1 42.0 cM
1307:MAP kinase pathway
977:ENSMUSG00000055980
725:Biological process
679:Cellular component
630:SH2 domain binding
613:Molecular function
4130:
4129:
3650:10.1021/bc070135v
3492:10.1002/hep.22856
1716:ductal carcinoma
1694:and MCF-7 cells.
1662:estrogen receptor
1188:
1187:
1184:
1183:
1157:
1156:
1122:
1121:
1101:
1100:
1075:
1074:
1054:
1053:
1028:
1027:
1009:
1008:
983:
982:
964:
963:
938:
937:
919:
918:
867:
866:
597:
596:
593:
592:
562:
561:
549:
548:
487:
486:
385:
384:
284:
283:
111:
110:
107:
106:
63:Ortholog search:
16:(Redirected from
4150:
4116:
4101:
4081:
4074:
4067:
4058:
4057:
4052:
4042:
4017:
4007:
3982:
3945:
3935:
3901:
3900:
3890:
3858:
3852:
3851:
3841:
3809:
3803:
3802:
3774:
3768:
3767:
3731:
3725:
3724:
3696:
3690:
3689:
3668:
3662:
3661:
3632:
3626:
3625:
3615:
3591:
3585:
3584:
3563:
3557:
3556:
3520:
3514:
3513:
3503:
3471:
3465:
3464:
3454:
3430:
3424:
3423:
3413:
3381:
3375:
3374:
3364:
3340:
3334:
3333:
3323:
3291:
3282:
3281:
3271:
3261:
3229:
3220:
3219:
3209:
3185:
3179:
3178:
3168:
3144:
3138:
3137:
3127:
3103:
3097:
3096:
3086:
3062:
3056:
3055:
3045:
3036:(41): 26908β14.
3021:
3015:
3014:
3004:
2995:(16): 11479β81.
2980:
2974:
2973:
2963:
2954:(48): 32244β53.
2939:
2933:
2932:
2922:
2898:
2892:
2891:
2881:
2849:
2843:
2842:
2832:
2808:
2802:
2801:
2791:
2767:
2761:
2760:
2750:
2726:
2720:
2719:
2709:
2685:
2679:
2678:
2668:
2636:
2630:
2629:
2619:
2610:(48): 28527β30.
2595:
2589:
2588:
2578:
2554:
2545:
2544:
2534:
2510:
2504:
2503:
2493:
2484:(40): 23456β60.
2469:
2463:
2462:
2452:
2428:
2422:
2421:
2411:
2387:
2378:
2377:
2367:
2343:
2337:
2336:
2299:
2290:
2289:
2279:
2256:The EMBO Journal
2247:
2241:
2240:
2230:
2198:
2192:
2191:
2181:
2149:
2140:
2139:
2111:
2105:
2104:
2094:
2062:
2056:
2055:
2037:
2012:
2006:
2005:
1957:
1951:
1950:
1940:
1908:
1897:
1896:
1894:
1893:
1879:
1873:
1872:
1853:10.1038/352073a0
1827:
1821:
1820:
1809:
1803:
1802:
1791:
1785:
1775:
1764:
1754:
1532:tumor suppressor
1512:insulin receptor
1350:ubiquitin ligase
1247:insulin receptor
1170:
1169:
1141:
1134:
1117:
1105:
1104:
1096:
1084:
1083:
1080:RefSeq (protein)
1070:
1058:
1057:
1049:
1037:
1036:
1013:
1012:
994:
993:
968:
967:
949:
948:
923:
922:
904:
903:
873:
872:
603:
602:
589:
580:
573:
572:
558:
534:digastric muscle
498:
496:Top expressed in
491:
490:
460:cartilage tissue
456:lactiferous duct
436:
434:Top expressed in
429:
428:
408:
407:
391:
390:
381:
368:
357:
342:
335:
329:
318:
306:
290:
289:
280:
267:
256:
241:
234:
228:
217:
203:
187:
186:
181:
179:IRS1 - orthologs
132:
125:
102:
77:
76:
71:
50:
49:
44:
32:
31:
21:
4158:
4157:
4153:
4152:
4151:
4149:
4148:
4147:
4133:
4132:
4131:
4126:
4123:
4117:
4108:
4102:
4088:
4085:
4055:
3909:
3907:Further reading
3904:
3859:
3855:
3824:(24): 9302β14.
3810:
3806:
3775:
3771:
3732:
3728:
3697:
3693:
3680:(11): 1429β36.
3669:
3665:
3633:
3629:
3592:
3588:
3575:(10): 2942β50.
3569:Cancer Research
3564:
3560:
3521:
3517:
3472:
3468:
3431:
3427:
3382:
3378:
3341:
3337:
3312:10.1038/nm.2084
3300:Nature Medicine
3292:
3285:
3230:
3223:
3186:
3182:
3159:(17): 11663β9.
3145:
3141:
3118:(10): 1768β80.
3104:
3100:
3063:
3059:
3022:
3018:
2981:
2977:
2940:
2936:
2913:(13): 1911β23.
2899:
2895:
2850:
2846:
2809:
2805:
2782:(29): 26550β7.
2768:
2764:
2741:(25): 17483β6.
2727:
2723:
2700:(12): 9047β54.
2686:
2682:
2637:
2633:
2596:
2592:
2555:
2548:
2511:
2507:
2470:
2466:
2429:
2425:
2388:
2381:
2344:
2340:
2311:(37): 5684β95.
2300:
2293:
2248:
2244:
2199:
2195:
2150:
2143:
2112:
2108:
2063:
2059:
2013:
2009:
1972:(5514): 104β6.
1958:
1954:
1923:(10): 2565β82.
1909:
1900:
1891:
1889:
1887:www.uniprot.org
1881:
1880:
1876:
1828:
1824:
1811:
1810:
1806:
1793:
1792:
1788:
1776:
1767:
1755:
1746:
1742:
1491:
1486:
1398:
1374:O-GlcNAcylation
1342:
1291:phosphorylation
1243:
1179:View/Edit Mouse
1174:View/Edit Human
1137:
1130:
1127:Location (UCSC)
1113:
1092:
1066:
1045:
958:ENSG00000169047
851:
720:
716:plasma membrane
674:
645:protein binding
585:
554:
545:
540:
536:
532:
528:
526:temporal muscle
524:
520:
516:
512:
508:
494:
483:
478:
474:
470:
466:
462:
458:
454:
450:
446:
432:
376:
363:
355:
345:
344:
343:
336:
316:
293:Gene location (
275:
262:
254:
244:
243:
242:
235:
213:
190:Gene location (
141:
128:
121:
86:
64:
30:
23:
22:
15:
12:
11:
5:
4156:
4146:
4145:
4128:
4127:
4125:
4124:
4118:
4111:
4109:
4103:
4096:
4093:
4090:
4089:
4084:
4083:
4076:
4069:
4061:
4054:
4053:
4018:
3983:
3946:
3910:
3908:
3905:
3903:
3902:
3867:Cancer Letters
3853:
3804:
3769:
3726:
3691:
3663:
3644:(6): 1831β40.
3627:
3586:
3558:
3531:(4): 490β500.
3515:
3486:(6): 1935β43.
3466:
3425:
3376:
3335:
3283:
3221:
3180:
3139:
3098:
3057:
3016:
2975:
2934:
2893:
2844:
2803:
2762:
2721:
2680:
2631:
2590:
2546:
2505:
2464:
2443:(11): 5980β3.
2423:
2379:
2338:
2291:
2262:(5): 1929β36.
2242:
2193:
2164:(4): 3125β35.
2141:
2106:
2071:Molecular Cell
2057:
2007:
1952:
1898:
1874:
1839:(6330): 73β7.
1822:
1804:
1786:
1765:
1743:
1741:
1738:
1547:adenocarcinoma
1490:
1489:Role in cancer
1487:
1485:
1484:
1478:
1472:
1466:
1460:
1454:
1449:
1443:
1437:
1431:
1425:
1419:
1413:
1406:
1397:
1394:
1341:
1338:
1242:
1239:
1186:
1185:
1182:
1181:
1176:
1166:
1165:
1159:
1158:
1155:
1154:
1152:
1150:
1143:
1142:
1135:
1128:
1124:
1123:
1120:
1119:
1109:
1108:
1102:
1099:
1098:
1088:
1087:
1081:
1077:
1076:
1073:
1072:
1062:
1061:
1055:
1052:
1051:
1041:
1040:
1034:
1030:
1029:
1026:
1025:
1017:
1016:
1010:
1007:
1006:
998:
997:
991:
985:
984:
981:
980:
972:
971:
965:
962:
961:
953:
952:
946:
940:
939:
936:
935:
927:
926:
920:
917:
916:
908:
907:
901:
895:
894:
889:
884:
880:
879:
869:
868:
865:
864:
853:
852:
850:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
728:
726:
722:
721:
719:
718:
713:
708:
703:
698:
693:
688:
682:
680:
676:
675:
673:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
616:
614:
610:
609:
599:
598:
595:
594:
591:
590:
582:
581:
570:
564:
563:
560:
559:
551:
550:
547:
546:
544:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
500:
499:
488:
485:
484:
482:
481:
477:
473:
472:biceps brachii
469:
465:
461:
457:
453:
449:
445:
441:
438:
437:
425:
424:
416:
405:
399:
398:
395:RNA expression
387:
386:
383:
382:
374:
370:
369:
361:
358:
353:
347:
346:
337:
330:
324:
320:
319:
314:
308:
307:
299:
298:
286:
285:
282:
281:
273:
269:
268:
260:
257:
252:
246:
245:
236:
229:
223:
219:
218:
211:
205:
204:
196:
195:
183:
182:
139:
135:
134:
126:
118:
117:
113:
112:
109:
108:
105:
104:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
9:
6:
4:
3:
2:
4155:
4144:
4141:
4140:
4138:
4121:
4115:
4110:
4106:
4100:
4095:
4094:
4091:
4082:
4077:
4075:
4070:
4068:
4063:
4062:
4059:
4050:
4046:
4041:
4036:
4033:(6): 705β13.
4032:
4028:
4024:
4019:
4015:
4011:
4006:
4001:
3997:
3993:
3989:
3984:
3980:
3976:
3972:
3968:
3964:
3960:
3957:(1): 147β51.
3956:
3952:
3951:Human Biology
3947:
3943:
3939:
3934:
3929:
3925:
3921:
3917:
3912:
3911:
3898:
3894:
3889:
3884:
3880:
3876:
3873:(2): 239β48.
3872:
3868:
3864:
3857:
3849:
3845:
3840:
3835:
3831:
3827:
3823:
3819:
3815:
3808:
3800:
3796:
3792:
3788:
3785:(1): 136β40.
3784:
3780:
3773:
3765:
3761:
3757:
3753:
3749:
3745:
3742:(5): 828β34.
3741:
3737:
3730:
3722:
3718:
3714:
3710:
3706:
3702:
3695:
3687:
3683:
3679:
3675:
3667:
3659:
3655:
3651:
3647:
3643:
3639:
3631:
3623:
3619:
3614:
3609:
3606:(6): 605β16.
3605:
3601:
3597:
3590:
3582:
3578:
3574:
3570:
3562:
3554:
3550:
3546:
3542:
3538:
3534:
3530:
3526:
3519:
3511:
3507:
3502:
3497:
3493:
3489:
3485:
3481:
3477:
3470:
3462:
3458:
3453:
3448:
3444:
3440:
3436:
3429:
3421:
3417:
3412:
3407:
3403:
3399:
3395:
3391:
3390:Endocrinology
3387:
3380:
3372:
3368:
3363:
3358:
3354:
3350:
3346:
3339:
3331:
3327:
3322:
3317:
3313:
3309:
3306:(2): 219β23.
3305:
3301:
3297:
3290:
3288:
3279:
3275:
3270:
3265:
3260:
3255:
3251:
3247:
3244:(4): e36190.
3243:
3239:
3235:
3228:
3226:
3217:
3213:
3208:
3203:
3200:(6): 705β13.
3199:
3195:
3191:
3184:
3176:
3172:
3167:
3162:
3158:
3154:
3150:
3143:
3135:
3131:
3126:
3121:
3117:
3113:
3109:
3102:
3094:
3090:
3085:
3080:
3077:(6): 4283β9.
3076:
3072:
3068:
3061:
3053:
3049:
3044:
3039:
3035:
3031:
3027:
3020:
3012:
3008:
3003:
2998:
2994:
2990:
2986:
2979:
2971:
2967:
2962:
2957:
2953:
2949:
2945:
2938:
2930:
2926:
2921:
2916:
2912:
2908:
2904:
2897:
2889:
2885:
2880:
2875:
2871:
2867:
2863:
2859:
2855:
2848:
2840:
2836:
2831:
2826:
2823:(5): 657β67.
2822:
2818:
2814:
2807:
2799:
2795:
2790:
2785:
2781:
2777:
2773:
2766:
2758:
2754:
2749:
2744:
2740:
2736:
2732:
2725:
2717:
2713:
2708:
2703:
2699:
2695:
2691:
2684:
2676:
2672:
2667:
2662:
2658:
2654:
2650:
2646:
2642:
2635:
2627:
2623:
2618:
2613:
2609:
2605:
2601:
2594:
2586:
2582:
2577:
2572:
2569:(3): 884β93.
2568:
2564:
2563:Endocrinology
2560:
2553:
2551:
2542:
2538:
2533:
2528:
2525:(6): 631β41.
2524:
2520:
2516:
2509:
2501:
2497:
2492:
2487:
2483:
2479:
2475:
2468:
2460:
2456:
2451:
2446:
2442:
2438:
2434:
2427:
2419:
2415:
2410:
2405:
2402:(2): 1531β7.
2401:
2397:
2393:
2386:
2384:
2375:
2371:
2366:
2361:
2358:(2): 656β60.
2357:
2353:
2349:
2342:
2334:
2330:
2326:
2322:
2318:
2314:
2310:
2306:
2298:
2296:
2287:
2283:
2278:
2273:
2269:
2265:
2261:
2257:
2253:
2246:
2238:
2234:
2229:
2224:
2220:
2216:
2213:(2): 735β46.
2212:
2208:
2204:
2197:
2189:
2185:
2180:
2175:
2171:
2167:
2163:
2159:
2155:
2148:
2146:
2137:
2133:
2129:
2125:
2122:(1): 99β109.
2121:
2117:
2110:
2102:
2098:
2093:
2088:
2084:
2080:
2077:(4): 403β14.
2076:
2072:
2068:
2061:
2053:
2049:
2045:
2041:
2036:
2031:
2028:(3): 807β18.
2027:
2023:
2022:FASEB Journal
2019:
2011:
2003:
1999:
1995:
1991:
1987:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1948:
1944:
1939:
1934:
1930:
1926:
1922:
1918:
1914:
1907:
1905:
1903:
1888:
1884:
1878:
1870:
1866:
1862:
1858:
1854:
1850:
1846:
1842:
1838:
1834:
1826:
1818:
1814:
1808:
1800:
1796:
1790:
1783:
1779:
1774:
1772:
1770:
1762:
1758:
1753:
1751:
1749:
1744:
1737:
1735:
1731:
1727:
1723:
1720:
1719:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1684:
1680:
1676:
1672:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1635:
1630:
1627:
1623:
1619:
1615:
1611:
1606:
1602:
1598:
1596:
1592:
1588:
1584:
1580:
1576:
1571:
1569:
1565:
1560:
1556:
1552:
1548:
1543:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1509:
1508:breast cancer
1505:
1501:
1497:
1482:
1479:
1476:
1473:
1470:
1467:
1464:
1461:
1458:
1455:
1453:
1450:
1447:
1444:
1441:
1438:
1435:
1432:
1429:
1426:
1423:
1420:
1417:
1414:
1411:
1408:
1407:
1405:
1403:
1393:
1391:
1387:
1383:
1382:hyperglycemia
1379:
1375:
1372:proteins and
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1337:
1335:
1334:knockout mice
1331:
1327:
1323:
1318:
1316:
1310:
1308:
1304:
1300:
1296:
1292:
1289:
1285:
1283:
1279:
1275:
1271:
1267:
1264:
1260:
1256:
1252:
1248:
1238:
1236:
1232:
1228:
1227:
1222:
1218:
1214:
1210:
1206:
1203:
1199:
1195:
1192:
1180:
1175:
1171:
1167:
1164:
1160:
1153:
1151:
1148:
1144:
1140:
1136:
1133:
1129:
1125:
1118:
1116:
1110:
1106:
1103:
1097:
1095:
1089:
1085:
1082:
1078:
1071:
1069:
1063:
1059:
1056:
1050:
1048:
1042:
1038:
1035:
1033:RefSeq (mRNA)
1031:
1024:
1023:
1018:
1014:
1011:
1005:
1004:
999:
995:
992:
990:
986:
979:
978:
973:
969:
966:
960:
959:
954:
950:
947:
945:
941:
934:
933:
928:
924:
921:
915:
914:
909:
905:
902:
900:
896:
893:
890:
888:
885:
881:
878:
874:
870:
863:
859:
854:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
729:
727:
724:
723:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
683:
681:
678:
677:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
617:
615:
612:
611:
608:
607:Gene ontology
604:
600:
588:
583:
579:
574:
571:
569:
565:
557:
552:
541:
537:
533:
530:body of femur
529:
525:
521:
517:
513:
509:
505:
504:
501:
497:
492:
489:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
442:
439:
435:
430:
427:
426:
423:
421:
417:
415:
414:
410:
409:
406:
404:
400:
396:
392:
388:
380:
375:
371:
367:
362:
352:
348:
341:
334:
328:
321:
313:
309:
305:
300:
296:
291:
287:
279:
274:
270:
266:
261:
251:
247:
240:
233:
227:
220:
216:
210:
206:
202:
197:
193:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
136:
131:
124:
119:
114:
103:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
4119:
4104:
4030:
4026:
3998:(6): 631β7.
3995:
3991:
3954:
3950:
3923:
3919:
3870:
3866:
3856:
3821:
3817:
3807:
3782:
3778:
3772:
3739:
3735:
3729:
3707:(3): 685β9.
3704:
3700:
3694:
3677:
3673:
3666:
3641:
3637:
3630:
3603:
3599:
3589:
3572:
3568:
3561:
3528:
3524:
3518:
3483:
3479:
3469:
3445:(2): 341β5.
3442:
3438:
3428:
3396:(1): 261β7.
3393:
3389:
3379:
3355:(6): 631β7.
3352:
3348:
3338:
3303:
3299:
3241:
3237:
3197:
3193:
3183:
3156:
3152:
3142:
3115:
3111:
3101:
3074:
3070:
3060:
3033:
3029:
3019:
2992:
2988:
2978:
2951:
2947:
2937:
2910:
2906:
2896:
2864:(3): 831β7.
2861:
2857:
2847:
2820:
2817:Diabetologia
2816:
2806:
2779:
2775:
2765:
2738:
2734:
2724:
2697:
2693:
2683:
2651:(2): 263β9.
2648:
2644:
2634:
2607:
2603:
2593:
2566:
2562:
2522:
2518:
2508:
2481:
2477:
2467:
2440:
2436:
2426:
2399:
2395:
2355:
2351:
2341:
2308:
2304:
2259:
2255:
2245:
2210:
2206:
2196:
2161:
2157:
2119:
2115:
2109:
2074:
2070:
2060:
2025:
2021:
2010:
1969:
1965:
1955:
1920:
1917:Diabetologia
1916:
1890:. Retrieved
1886:
1877:
1836:
1832:
1825:
1816:
1807:
1798:
1789:
1721:
1717:
1711:
1703:
1699:
1654:antiestrogen
1631:
1621:
1599:
1579:hepatitis Bx
1572:
1544:
1492:
1399:
1396:Interactions
1343:
1319:
1311:
1303:PI3K pathway
1286:
1244:
1230:
1224:
1201:
1193:
1190:
1189:
1112:
1091:
1065:
1044:
1020:
1001:
975:
956:
930:
911:
891:
886:
772:MAPK cascade
510:pineal gland
418:
411:
276:226,799,820
263:226,731,312
138:External IDs
85:
26:
4087:PDB gallery
1734:vincristine
1555:neutrophils
1388:metabolite
1364:, TNFΞ± and
1362:fatty acids
1299:PTB domains
377:82,269,137
364:82,210,822
116:Identifiers
4027:Cell Cycle
3992:Cell Cycle
3480:Hepatology
3349:Cell Cycle
3194:Cell Cycle
1892:2016-04-21
1784:, May 2017
1763:, May 2017
1740:References
1696:Transgenic
1549:cell line
1496:colorectal
1390:UDP-GlcNAc
1386:hexosamine
1358:proteasome
1340:Regulation
1266:MAP kinase
1226:Drosophila
1213:PTB domain
422:(ortholog)
159:HomoloGene
2116:Biochimie
1730:etoposide
1671:Estradiol
1658:Tamoxifen
1587:displasia
1520:Ξ²-catenin
1354:ubiquitin
1330:phenotype
1326:mitogenic
1322:metabolic
1249:(IR) and
1115:NP_034700
1094:NP_005535
1068:NM_010570
1047:NM_005544
877:Orthologs
686:cytoplasm
167:GeneCards
4137:Category
4049:17374994
4014:17361103
3971:15222685
3942:10856136
3897:23562473
3848:17030631
3799:18834857
3721:11676497
3658:17922544
3622:11230180
3581:12019176
3553:19294187
3545:11313980
3525:Oncogene
3510:19475691
3420:17916629
3371:17361103
3330:20081861
3278:22558377
3238:PLOS ONE
3216:17374994
3134:11579209
3093:10660596
2888:10417350
2839:12107746
2798:12730242
2716:10722755
2675:11208867
2418:11606564
2325:12173038
2305:Oncogene
2237:10679027
2188:10082579
2136:15733744
2101:18498745
2052:12387212
2044:17928362
2002:30331471
1994:11292874
1947:22869320
1780:–
1759:–
1700:in vitro
1679:promoter
1626:biopsies
1614:integrin
1545:In lung
1514:(InsR),
1504:prostate
1402:interact
1346:Cullin-7
1305:and the
1288:Tyrosine
1241:Function
1229:protein
1163:Wikidata
856:Sources:
506:calvaria
3979:7884744
3888:3761875
3839:1698542
3764:8237080
3756:9311601
3686:9815941
3501:2754284
3461:9466558
3452:1857952
3411:2194604
3321:2821801
3269:3338610
3246:Bibcode
3175:9111084
3052:9756938
3011:8505282
2970:9822703
2929:9415396
2879:1220424
2757:1381348
2666:2193341
2626:7499365
2585:9492017
2541:8776723
2500:7559507
2459:8626379
2374:8536716
2333:2899858
2286:8491186
2092:2633441
1974:Bibcode
1966:Science
1938:4011499
1869:4311960
1861:1648180
1841:Bibcode
1782:Ensembl
1761:Ensembl
1718:in situ
1712:in vivo
1704:in vivo
1650:insulin
1622:Ex vivo
1524:TCF/LEF
1198:protein
1194:(IRS-1)
989:UniProt
944:Ensembl
883:Species
862:QuickGO
711:cytosol
706:nucleus
696:caveola
468:decidua
397:pattern
123:Aliases
4047:
4012:
3977:
3969:
3940:
3895:
3885:
3846:
3836:
3797:
3762:
3754:
3719:
3684:
3656:
3620:
3579:
3551:
3543:
3508:
3498:
3459:
3449:
3418:
3408:
3369:
3328:
3318:
3276:
3266:
3214:
3173:
3132:
3091:
3050:
3009:
2968:
2927:
2886:
2876:
2837:
2796:
2755:
2714:
2673:
2663:
2624:
2583:
2539:
2498:
2457:
2416:
2372:
2331:
2323:
2284:
2277:413414
2274:
2235:
2225:
2186:
2176:
2134:
2099:
2089:
2050:
2042:
2000:
1992:
1945:
1935:
1867:
1859:
1833:Nature
1732:, and
1692:HEK293
1688:mir126
1610:Akt/PK
1477:, and
1469:PTPN11
1457:PIK3R3
1452:PIK3R1
1295:ligand
1149:search
1147:PubMed
1022:P35569
1003:P35568
899:Entrez
568:BioGPS
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