1200:, it is generally advised to match the serostatus of donor and recipient. If the recipient is seronegative, a seropositive donor carries a risk of de novo infection. Conversely, a seropositive recipient is at risk of viral reactivation if they receive a transplant from a seronegative donor, losing their innate defenses in the process. In general, the risk is highest for CMV seropositive recipients, in which viral reactivation is a cause of significant morbidity. For these reasons, CMV serologic testing is routine for both bone marrow donors and recipients.
1106:
treatment in people who are under immunosuppressive therapy and have had renal transplantation surgery, as the antigenemia results are obtained about 5 days before the onset of symptomatic CMV disease. The advantage of this assay is the rapidity in providing results in a few hours and that the pp65 antigen determination represents a useful criterion for the physician to initiate antiviral therapy. The major disadvantage of the pp65 assay is that only a limited number of samples can be processed per test batch.
106:
85:
1328:
840:
1176:
caused by acquired CMV infection. If serologic tests detect a positive or high titer of IgG, this result should not automatically be interpreted to mean that active CMV infection is present. Active CMV infection is considered to be present if antibody tests of paired serum samples show a fourfold rise in IgG antibody and a significant level of IgM antibody (equal to at least 30% of the IgG value), or if virus is cultured from a urine or throat specimen.
6623:
1021:
1082:
1290:(Valcyte) is an antiviral drug that is also effective and is given orally: it is a pro-drug that gets converted into ganciclovir in the body, but is much better absorbed orally than the latter. The therapeutic effectiveness is frequently compromised by the emergence of drug-resistant virus isolates. A variety of amino acid changes in the UL97 protein kinase and the viral DNA polymerase have been reported to cause drug resistance.
771:
1188:(donations not specified for a particular person) in the U.S., the UK and many other countries. CMV-negative donations are then earmarked for transfusion to infants or people who are immunocompromised. Some blood donation centers maintain lists of donors whose blood is CMV negative due to special demands.
1368:
activity. This causes enhanced recognition of incorporated GCV and CDV. As a result, these dNTP analogues are excised more efficiently. Major risk factors for HCMV drug resistance are the residual capacity of the host's immune system to control viral replication and the overall amount and duration of
1359:
acts through a mechanism that involves viral terminase). Two HCMV proteins are implicated in antiviral resistance against these three drugs: pUL97 and pUL54. Specific mutations in pUL97 can cause reduced phosphorylation activity of this viral protein kinase. Thus, fewer monophosphorylated – and thus
1369:
viral replication. HCMV antiviral drug resistance can be detected by phenotypic or by genotypic drug resistance testing. Phenotypic resistance testing involves cultivation of the virus in cell culture and testing its susceptibility using different antiviral drug concentrations in order to determine
1132:
For best diagnostic results, laboratory tests for CMV antibody should be performed by using paired serum samples. One blood sample should be taken upon suspicion of CMV, and another one taken within 2 weeks. A virus culture can be performed any time the person is symptomatic. Laboratory testing for
1105:
The CMV pp65 antigenemia test is an immunofluorescence-based assay which utilizes an indirect immunofluorescence technique for identifying the pp65 protein of cytomegalovirus in peripheral blood leukocytes. The CMV pp65 assay is widely used for monitoring CMV infection and its response to antiviral
1093:
to the virus, which persist in the body for the lifetime of that individual. A number of laboratory tests that detect these antibodies to CMV have been developed to determine if infection has occurred and are widely available from commercial laboratories. In addition, the virus can be cultured from
1175:
before the serum sample is tested. Because CMV-specific IgM may be produced in low levels in reactivated CMV infection, its presence is not always indicative of primary infection. Only virus recovered from a target organ, such as the lung, provides unequivocal evidence that the current illness is
546:
In disseminated cytomegalovirus infections, as may be seen in the context of an immunosuppressed host, the virus is readily transmitted between polymorphonuclear leukocytes (PM-NLs) and endothelial cells. Infected endothelial cells produce cytokines that attract PM-NLs, which then adhere to the
1268:
enriched for CMV (CMV-IGIV) is an immunoglobulin G (IgG) containing a standardized number of antibodies to cytomegalovirus. It may be used for the prophylaxis of cytomegalovirus disease associated with transplantation of kidney, lung, liver, pancreas, and heart. Alone or in combination with an
1145:) is the most commonly available serologic test for measuring antibody to CMV. The result can be used to determine if acute infection, prior infection, or passively acquired maternal antibody in an infant is present. Other tests include various fluorescence assays, indirect
1587:
Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T (10 November 2011). "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship".
1002:
A substantial portion of the immune system is involved in continuously controlling CMV, which drains the resources of the immune system. Death rates from infectious disease accelerate with age, and CMV infection correlates with reduced effectiveness of
475:. Cytomegalovirus is most commonly transmitted through kissing and sexual intercourse. It can also be transferred from an infected mother to her unborn child. Infection requires close, intimate contact with a person secreting the virus in their
753:
The question of whether latent CMV infection has any negative effects on people who are otherwise healthy has been debated; as of 2016 the answer was not clear, but discussions had focused on whether latent CMV might increase the risk of some
999:, which prevents their surface expression. These ligands are normally upregulated in times of cellular stress, such as in viral infection, and by preventing their upregulation, CMV can prevent its host cell from dying due to NK cells
2963:
Brecht, Katharina F.; Goelz, Rangmar; Bevot, Andrea; Krägeloh-Mann, Ingeborg; Wilke, Marko; Lidzba, Karen (1 April 2015). "Postnatal Human
Cytomegalovirus Infection in Preterm Infants Has Long-Term Neuropsychological Sequelae".
1133:
antibodies to CMV can be performed to determine if a woman has already had CMV infection. However, routine testing of all pregnant women is costly and the need for testing should therefore be evaluated on a case-by-case basis.
1717:
Kumar, Amit; Tripathy, Manoj Kumar; Pasquereau, SĂ©bastien; Al
Moussawi, Fatima; Abbas, Wasim; Coquard, Laurie; Khan, Kashif Aziz; Russo, Laetitia; Algros, Marie-Paule; Valmary-Degano, SĂ©verine; Adotevi, Olivier (April 2018).
3276:
Klemola E, Von Essen R, Henle G, Henle W (June 1970). "Infectious-mononucleosis-like disease with negative heterophil agglutination test. Clinical features in relation to
Epstein–Barr virus and cytomegalovirus antibodies".
1223:
of a CMV-vaccine published in 2009 indicated an efficacy of 50%—the protection provided was limited, and a number of subjects contracted CMV infection despite vaccination. In one case also congenital CMV was encountered.
1360:
active – GCV can be synthesized, leading to antiviral resistance against GCV. About 90% of all GCV resistances are caused by such mutations in UL97. Mutations in pUL54 may have different effects leading to antiviral
1364:: A. They can lead to decreased affinity to antiviral compounds. This resistance mechanism concerns GCV, CDV and FOS and may lead to multidrug resistance. B. Some mutations in pUL54 can increase the polymerase's
5391:
5376:
2252:
630:
with nonspecific signs that resemble rubella. Another five percent later develop cerebral calcification (decreasing IQ levels dramatically and causing sensorineural deafness and psychomotor retardation).
3881:"Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly"
1089:
Most infections with CMV go undiagnosed, as the virus usually produces few, if any, symptoms and tends to reactivate intermittently without symptoms. Persons who have been infected with CMV develop
1377:. Genotypic resistance testing is becoming the method of choice because it is faster, but requires previous phenotypic characterisation of each newly found mutation. This can be performed via a
515:, which requires expression of only a trimeric viral receptor complex, rather than the full pentameric complex that is required for infection of endothelial and epithelial cells. Like other
1257:(CDC) recommend regular hand washing, especially after changing diapers. Hand washing is also recommended after feeding a child, wiping a child's nose or mouth, or handling children's toys.
4797:
5005:"A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate"
3184:
Albekairy, Abdulkareem M.; Shawaqfeh, Mohammad S.; Alharbi, Shroug H.; Almuqbil, Faisal; Alghamdi, Mesfer A.; Albekairy, Nataleen A.; Muflih, Suhaib M.; Alkatheri, Abdulmalik (2022).
4911:
Sullivan V, Talarico CL, Stanat SCC, Davis M, Coen DM, Biron KK (1992). "A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells".
569:
Nearly 75% of the genes encoded by HCMV strain AD169 can be deleted and still result in the production of infectious virus. This suggests that the virus focuses on avoiding the host
4688:
Avery, R. K.; Arav-Boger, R.; Marr, K. A.; Kraus, E.; Shoham, S.; Lees, L.; Trollinger, B.; Shah, P.; Ambinder, R.; Neofytos, D.; Ostrander, D.; Forman, M.; Valsamakis, A. (2016).
332:
can lead to significant morbidity and even death. After infection, HCMV remains latent within the body throughout life and can be reactivated at any time. Eventually, it may cause
5306:
4833:
5197:
Chevillotte M, von Einem J, Meier BM, Lin FM, Kestler HA, Mertens T (2010). "A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes".
1538:"Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients"
4490:"A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic, Hematopoietic Cell Transplant (HCT) (HELIOS)"
2613:
Stern-Ginossar, Noam; Weisburd, Ben; Michalski, Annette; Le, Vu Thuy Khanh; Hein, Marco Y.; Huang, Sheng-Xiong; Ma, Ming; Shen, Ben; Qian, Shu-Bing (23 November 2012).
7669:
3185:
535:. Late genes are expressed during the remainder of infection up to viral egress and typically code for structural proteins. While HCMV encodes for its own functional
3830:
Welte, Stefan A.; Sinzger, Christian; Lutz, Stefan Z.; Singh-Jasuja, Harpreet; Sampaio, Kerstin Laib; Eknigk, Ute; Rammensee, Hans-Georg; Steinle, Alexander (2003).
1396:
In the United States, CMV infection rises with age from about 60% of people infected by 6 years of age leveling off at about 85–90% of the population by ages 75–80.
7234:
379:
is age-dependent: 58.9% of individuals aged 6 and older are infected with CMV while 90.8% of individuals aged 80 and older are positive for HCMV. HCMV is also the
4534:"Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant"
1241:
Further cytomegalovirus vaccines candidates are the CMV-MVA Triplex vaccine and the CMVpp65-A*0201 peptide vaccine. Both vaccine candidates are sponsored by the
714:, and regular serological monitoring to detect a rising CMV titre; if treated early establishment of a potentially life-threatening infection can be prevented.
1388:
that links a person's HCMV sequence to a database containing all published UL97 and UL54 mutations and corresponding antiviral drug susceptibility phenotypes.
1319:
A better understanding of how HCMV supports viral latency and reactivation should allow for the development of new therapies that target the latent reservoir.
805:, is followed by a prolonged, inapparent infection during which the virus resides in mononuclear cells without causing detectable damage or clinical illness.
4512:"An Evaluation of a Cytomegalovirus (CMV) Vaccine (ASP0113) in CMV-Seropositive and CMV-Seronegative Healthy Subjects and CMV-Seronegative Dialysis Patients"
5233:
4964:"Foscarnet. A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis"
4345:"Donor cytomegalovirus status influences the outcome of allogeneic stem cell transplant: a study by the European group for blood and marrow transplantation"
4019:
2558:"Temporal patterns of human cytomegalovirus transcription: mapping the viral RNAs synthesized at immediate early, early, and late times after infection"
1007:. Persons with the highest levels of CMV antibodies have a much higher risk of death from all causes compared with persons having few or no antibodies.
2289:
2843:
1298:
are only given to people with CMV resistant to ganciclovir, because foscarnet has notable nephrotoxicity, resulting in increased or decreased Ca or PO
6657:
4556:"Vaccine Therapy in Reducing the Frequency of Cytomegalovirus Events in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant"
4786:
3361:
Pak, Chiny; McArthur, Robertg; Eun, Hyone-Myong; Yoon, Ji-Won (1988). "Association of
Cytomegalovirus Infection with Autoimmune Type 1 Diabetes".
7915:
925:
A study published in 2009 links infection with CMV to high blood pressure in mice, and suggests that the result of CMV infection of blood vessel
1094:
specimens obtained from urine, throat swabs, bronchial lavages and tissue samples to detect active infection. Both qualitative and quantitative
7662:
6617:
7969:
7248:
3924:"Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans"
7997:
5333:
4020:"Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination"
1881:
El Baba, Ranim; Pasquereau, Sébastien; Haidar Ahmad, Sandy; Monnien, Franck; Abad, Marine; Bibeau, Frédéric; Herbein, Georges (June 2023).
1381:
8007:
3488:
1511:
Koichi
Yamanishi; Arvin, Ann M.; Gabriella Campadelli-Fiume; Edward Mocarski; Moore, Patrick; Roizman, Bernard; Whitley, Richard (2007).
4639:
6914:
6745:
5324:
4582:
4577:
3967:
1343:(GCV) acts as nucleoside analogue. Its antiviral activity requires phosphorylation by the HCMV protein kinase, pUL97. The second drug,
1254:
2248:"Cytomegalovirus Primary Infection in an Immunocompetent Female with Mononucleosis Features: A Review of Mononucleosis-Like Syndromes"
1832:
Guyon, Joris; Haidar Ahmad, Sandy; El Baba, Ranim; Le Quang, MĂ©gane; Bikfalvi, Andreas; Daubon, Thomas; Herbein, Georges (July 2024).
371:
and represents a lifelong burden of antigenic T cell surveillance and immune dysfunction. Commonly it is indicated by the presence of
7655:
6785:
3504:"Histopathological detection of owl's eye inclusions is still specific for cytomegalovirus in the era of human herpesviruses 6 and 7"
3105:
1631:
Geder L, Sanford EJ, Rohner TJ, Rapp F (1977). "Cytomegalovirus and cancer of the prostate: in vitro transformation of human cells".
4822:
1042:
495:. Although HCMV is not highly contagious, it has been shown to spread in households and among young children in day care centers.
5445:
2232:
6626:
5311:
976:
854:
with peri-nuclear clearing. Two cells (centre-right) have the characteristic (cytoplasmic) viral inclusion bodies (small pink
634:
However, infants born preterm and infected with HCMV after birth may experience cognitive and motor impairments later in life.
55:
4138:"Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States"
646:—for example people who have received transplants or are significantly burned—causes illness and increases the risk of death.
6650:
3161:
2776:
Dunn, Walter; Chou, Cassie; Li, Hong; Hai, Rong; Patterson, David; Stolc, Viktor; Zhu, Hua; Liu, Fenyong (25 November 2003).
1520:
1490:
1373:
values. In contrast, genotypic resistance testing means the detection of resistance associated mutations in UL97 and UL54 by
1286:(Cytovene) treatment is used for people with depressed immunity who have either sight-related or life-threatening illnesses.
17:
7828:
4690:"Outcomes in Transplant Recipients Treated with Foscarnet for Ganciclovir-Resistant or Refractory Cytomegalovirus Infection"
1231:
started on individuals who received a hematopoietic stem cell transplant a phase 3 trial with its CMV deoxyribonucleic acid
7809:
7700:
6878:
1242:
620:
598:
329:
4671:
4317:
706:
People without CMV infection who are given organ transplants from CMV-infected donors require prophylactic treatment with
459:
The mode of HCMV transmission from person to person is unknown, but is presumed to occur through bodily fluids, including
6935:
3404:
Lohr, J.M; Oldstone, M.B.A (1990). "Detection of cytomegalovirus nucleic acid sequences in pancreas in type 2 diabetes".
355:
HCMV is found in all geographic locations and all socioeconomic groups, and infects between 60% and 70% of adults in the
1775:
El Baba, Ranim; Haidar Ahmad, Sandy; Monnien, Franck; Mansar, Racha; Bibeau, Frédéric; Herbein, Georges (October 2023).
6336:
3062:
2729:"Formation of cytomegalovirus DNA replication compartments defined by localization of viral proteins and DNA synthesis"
1197:
415:
in children. CMV also "seems to have a large impact on immune parameters in later life and may contribute to increased
559:. Microfusions between the cells then take place in a manner dependent on expression of the viral gene locus UL128L.
7893:
7254:
6780:
6737:
6501:
5970:
5865:
3785:
2314:
1184:
Although the risks discussed above are generally low, CMV assays are part of the standard screening for non-directed
1068:
1050:
7678:
7240:
7169:
6643:
6451:
6331:
6080:
4609:
4083:
3832:"Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein"
1238:
In 2015, Astellas Pharma commenced on healthy volunteers a phase 1 trial with its cytomegalovirus vaccine ASP0113.
604:
384:
7974:
5343:
3965:
Pawelec G, Koch S, Franceschi C, Wikby A (2006). "Human immunosenescence: does it have an infectious component?".
1447:
6411:
5274:
4060:
6839:
6825:
6396:
6391:
3634:
1046:
4079:"Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up"
1777:"Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells"
746:
7200:
6594:
6205:
6100:
6025:
5925:
5920:
5905:
5900:
5835:
5810:
1542:
1414:
627:
7277:
2680:"RNA polymerase II localizes at sites of human cytomegalovirus immediate-early RNA synthesis and processing"
105:
7715:
7044:
7038:
6949:
6943:
6833:
6579:
6574:
6356:
6341:
6291:
6180:
6175:
6170:
6120:
5805:
5765:
484:
7695:
7407:
7333:
7327:
7000:
6569:
6564:
6554:
6491:
6456:
6351:
5955:
5895:
5890:
5830:
5790:
5738:
5438:
3928:
3922:
Derhovanessian E, Maier AB, Hähnel K, Beck R, de Craen AJ, Slagboom EP, Westendorp RG, Pawelec G (2011).
3879:
Hadrup SR, Strindhall J, Køllgaard T, Seremet T, Johansson B, Pawelec G, thor
Straten P, Wikby A (2006).
7752:
2442:
Emery, Vincent C.; Cope, Alethea V.; Bowen, E. Frances; Gor, Dehila; Griffiths, Paul D. (19 July 1999).
1327:
8002:
7773:
6544:
6539:
6406:
6371:
6366:
6245:
6210:
6095:
6090:
5965:
5915:
5880:
5855:
5241:
3551:
Bennekov T, Spector D, Langhoff E (March 2004). "Induction of immunity against human cytomegalovirus".
532:
4270:"Diagnosis and Management of Human Cytomegalovirus Infection in the Mother, Fetus, and Newborn Infant"
1660:"Polyploid Giant Cancer Cells Generated from Human Cytomegalovirus-Infected Prostate Epithelial Cells"
1510:
626:
Up to 5 of every 1,000 live births are infected. Five percent develop multiple handicaps, and develop
7464:
7071:
6549:
6496:
6401:
6361:
6285:
6115:
6110:
6030:
5985:
5980:
5975:
5950:
5945:
5910:
5860:
5800:
5795:
5785:
5760:
5648:
3734:
3683:
1309:
1095:
666:
7173:
7085:
6990:
6820:
6793:
6765:
6698:
6589:
6584:
6559:
6486:
6481:
6476:
6416:
6346:
6279:
6235:
6230:
6200:
6105:
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6070:
6020:
6015:
6010:
6005:
6000:
5995:
5990:
5960:
5875:
5870:
5406:
3186:"Prophylaxis of Cytomegalovirus Infection in Solid Organ Transplantation, Retrospective Evaluation"
1110:
1031:
782:
524:
333:
308:
Although they may be found throughout the body, HCMV infections are frequently associated with the
1273:
Reduce the risk of CMV-related disease and death in some of the highest-risk transplant recipients
877:
HCMV infection is important to certain high-risk groups. Major areas of risk of infection include
8012:
7705:
6969:
6431:
6426:
6421:
6250:
6240:
6150:
6145:
6140:
6035:
5658:
5653:
5613:
1214:
1035:
734:
only). However, the mononucleosis syndrome associated with CMV typically lacks signs of enlarged
680:
412:
302:
6635:
5330:
3730:"Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections"
2387:"Efficient Lytic Infection of Human Arterial Endothelial Cells by Human Cytomegalovirus Strains"
1378:
7920:
7855:
7363:
7341:
7220:
7216:
7212:
7208:
7163:
7101:
6995:
6956:
6759:
6255:
5688:
5683:
5678:
5628:
5623:
5618:
5431:
3058:"Cytomegalovirus reactivation in "immunocompetent" patients: a call for scientific prophylaxis"
1351:(FOS) has a different mode of action. It directly inhibits polymerase function by blocking the
1114:
972:
symptom severity is associated with CMV, although the exact mechanism has not been elucidated.
755:
731:
312:. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the
3227:"Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review"
3151:
3149:
1720:"The Human Cytomegalovirus Strain DB Activates Oncogenic Pathways in Mammary Epithelial Cells"
7348:
6929:
6799:
6770:
5716:
4647:
3885:
2283:
1834:"Generation of glioblastoma in mice engrafted with human cytomegalovirus-infected astrocytes"
945:
527:, followed by early genes (expressed 4–48 hours after infection) which are involved in viral
408:
6622:
4587:
808:
Infectious CMV may be shed in the bodily fluids of any infected person, and can be found in
801:
is suppressed either by drugs, infection or old age. Initial HCMV infection, which often is
7902:
7612:
7444:
7079:
6908:
5016:
4920:
4151:
3976:
3696:
2789:
2626:
2247:
2246:
Sarma, Shohinee; Little, Derek; Ali, Tooba; Jones, Emily; Haider, Shariq (27 August 2018).
1347:(CDV), is a nucleotide analogue, which is already phosphorylated and thus active. Finally,
1265:
735:
722:
CMV infections can still be of clinical significance in adult immunocompetent populations.
520:
396:
392:
100:
1658:
Bouezzedine, Fidaa; El Baba, Ranim; Haidar Ahmad, Sandy; Herbein, Georges (January 2023).
777:
Most healthy people who are infected by HCMV after birth have no symptoms. Some develop a
8:
7735:
7030:
6751:
5593:
5588:
5583:
5500:
5395:
3449:"Infectious mononucleosis-like syndromes in febrile travelers returning from the tropics"
2914:"Maternal Immunity and the Natural History of Congenital Human Cytomegalovirus Infection"
2087:
1150:
941:
5020:
4924:
4344:
4155:
3980:
2793:
2630:
1915:
1883:"EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes"
1866:
1809:
1776:
1694:
1659:
964:
are CMV-specific, but these may expand to as much as 30% in the elderly, 50% or more of
7424:
7419:
7133:
6889:
6270:
5729:
5266:
5179:
5087:
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4888:
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4105:
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3729:
3705:
3678:
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3579:
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3503:
3429:
3386:
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3226:
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3132:
3035:
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2913:
2889:
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2857:
2655:
2614:
2530:
2503:
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2443:
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2209:
2182:
2158:
2141:
2117:
2082:
2017:
1990:
1966:
1939:
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1719:
1613:
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225:
190:
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2825:
2807:
2758:
2750:
2709:
2701:
2660:
2642:
2595:
2577:
2535:
2481:
2463:
2424:
2406:
2402:
2367:
2320:
2310:
2214:
2163:
2122:
2104:
2063:
2022:
1971:
1920:
1902:
1882:
1853:
1833:
1814:
1796:
1757:
1739:
1699:
1681:
1640:
1605:
1569:
1516:
1486:
1165:
886:
643:
540:
492:
368:
363:. Of all herpes viruses, HCMV harbors the most genes dedicated to altering (evading)
313:
289:
50:
7647:
5210:
5183:
5091:
4122:
4056:
4004:
3865:
3663:
3390:
2275:
2040:
Staras SA, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ (November 2006).
1617:
874:, the inclusion bodies stain dark pink and are called "owl's eye" inclusion bodies.
7961:
7572:
7282:
6962:
6894:
6775:
6706:
5250:
5206:
5163:
5126:
5118:
5071:
5034:
5024:
4975:
4948:
4928:
4883:
4873:
4864:
4860:"Modulation of host cell signaling during cytomegalovirus latency and reactivation"
4758:
4750:
4709:
4701:
4461:
4453:
4412:
4404:
4356:
4289:
4281:
4226:
4210:
4169:
4159:
4100:
4092:
4036:
3984:
3937:
3894:
3843:
3802:
3794:
3751:
3743:
3700:
3692:
3643:
3632:
Wei W, Ji S (2018). "Cellular senescence: Molecular mechanisms and pathogenicity".
3601:
3591:
3523:
3515:
3460:
3433:
3413:
3370:
3325:
3286:
3248:
3238:
3197:
3136:
3114:
3071:
3039:
3019:
2973:
2935:
2925:
2884:
2815:
2797:
2740:
2691:
2650:
2634:
2585:
2569:
2525:
2515:
2471:
2455:
2414:
2398:
2261:
2204:
2194:
2153:
2112:
2096:
2053:
2012:
2002:
1961:
1951:
1910:
1894:
1861:
1845:
1804:
1788:
1747:
1731:
1689:
1671:
1597:
1559:
1551:
1169:
1146:
957:
890:
867:
866:
CMV infection can be demonstrated microscopically by the detection of intranuclear
586:
504:
321:
7536:
5270:
5122:
4555:
4533:
4511:
4489:
4285:
4254:
4040:
2573:
933:. Researchers also found that when the cells were infected with CMV, they created
797:
in the body for the rest of the person's life. Overt disease rarely occurs unless
7947:
7496:
7401:
7321:
7310:
7181:
7145:
7065:
6851:
6712:
6131:
6061:
5411:
5337:
5301:
4675:
4164:
3596:
3010:
Navarro, D (July 2016). "Expanding role of cytomegalovirus as a human pathogen".
1385:
1361:
1228:
930:
684:
528:
364:
337:
294:
267:
202:
5423:
4705:
3899:
3880:
3314:"The Relationship between Cytomegalovirus Infection and Guillain-Barre Syndrome"
2977:
2083:"Congenital Human Cytomegalovirus Infection and the Enigma of Maternal Immunity"
1735:
1601:
1098:(PCR) testing for CMV are available as well, allowing physicians to monitor the
403:
in industrialized countries. Congenital HCMV is the leading infectious cause of
6732:
6613:
5936:
5486:
5474:
5003:
Biron KK, Fyfe JA, Stanat SC, Leslie LK, Sorrell JB, Lambe CU, Coen DM (1986).
4878:
4668:
4321:
4214:
4018:
Derhovanessian E, Theeten H, Hähnel K, Van Damme P, Cools N, Pawelec G (2013).
3798:
3290:
2696:
2679:
1898:
1849:
1792:
1336:
1287:
1185:
1161:
833:
707:
674:
616:
574:
536:
420:
376:
345:
309:
142:
5254:
4408:
3225:
Rafailidis, PI; Mourtzoukou, EG; Varbobitis, IC; Falagas, ME (27 March 2008).
2304:
7991:
7820:
7757:
7745:
7725:
6727:
6722:
6670:
6161:
5707:
5639:
5574:
5480:
5468:
5456:
5296:
4222:
3339:
3150:
Meinhard
Classen; Guido N. J. Tytgat; M.D. PhD; Charles J. Lightdale (2010).
2985:
2811:
2754:
2705:
2646:
2581:
2467:
2410:
2355:
2266:
2108:
2042:"Seroprevalence of cytomegalovirus infection in the United States, 1988–1994"
1956:
1906:
1857:
1800:
1743:
1685:
1352:
1220:
961:
798:
727:
661:
608:
570:
516:
488:
341:
283:
273:
178:
166:
154:
130:
31:
5385:
5029:
3988:
2802:
2638:
2520:
1676:
922:, causing massive cell enlargement, which is the source of the virus' name.
7833:
7588:
7438:
7116:
6977:
6530:
6442:
6221:
5846:
5669:
5604:
5262:
5218:
5175:
5140:
5083:
4897:
4772:
4723:
4475:
4426:
4370:
4303:
4240:
4183:
4114:
4048:
3996:
3951:
3942:
3923:
3908:
3857:
3848:
3831:
3816:
3765:
3714:
3655:
3615:
3564:
3537:
3474:
3347:
3262:
3243:
3128:
3085:
2993:
2949:
2898:
2829:
2745:
2728:
2664:
2539:
2485:
2428:
2371:
2324:
2218:
2199:
2167:
2126:
2067:
2026:
1975:
1924:
1818:
1761:
1703:
1609:
1573:
949:
919:
871:
859:
851:
802:
739:
563:
508:
400:
349:
5048:
4989:
4940:
4457:
3502:
Mattes FM, McLaughlin JE, Emery VC, Clark DA, Griffiths PD (August 2000).
3425:
3382:
3298:
3031:
2762:
2713:
2599:
2459:
2007:
562:
Synthesis of the viral double-stranded DNA genome occurs at the host cell
7887:
7878:
7804:
7788:
7778:
7710:
7628:
7577:
7565:
7560:
7553:
7541:
7515:
7485:
7387:
7226:
7138:
7121:
7056:
6717:
6512:
5533:
4754:
4361:
4096:
3580:"Cytomegalovirus infection causes an increase of arterial blood pressure"
3519:
3330:
3313:
3202:
2342:
Sexually
Transmitted Diseases Sourcebook. Health Reference Series Detroit
2100:
1555:
1365:
1340:
1283:
1126:
1122:
1118:
1117:, or if they show signs of hepatitis, but have negative test results for
1004:
926:
915:
847:
829:
794:
711:
697:
691:
512:
439:
360:
356:
4617:
1644:
839:
793:. A sore throat is common. After infection, the virus remains latent in
523:(expressed 0–4 hours after infection) are involved in the regulation of
7478:
7262:
7019:
6467:
6304:
5821:
5776:
2873:"Cytomegalovirus Infection in Pregnancy: Should All Women be Screened?"
1991:"Cytomegalovirus-induced immunopathology and its clinical consequences"
1374:
1356:
1305:
1099:
1090:
855:
843:
443:
372:
93:
5154:
Drew WL (2000). "Ganciclovir resistance: a matter of time and titre".
3647:
3224:
3119:
3100:
3023:
2930:
7783:
7523:
7504:
7471:
7459:
7453:
7432:
7378:
7306:
7192:
7154:
6923:
6902:
6808:
6686:
6678:
6666:
6382:
6191:
5751:
5515:
5062:
Chou S (1999). "Antiviral drug resistance in human cytomegalovirus".
4932:
4136:
Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE (2011).
1657:
1348:
1344:
1295:
1291:
882:
878:
790:
552:
416:
388:
84:
7849:
5231:
4017:
3747:
2844:"Human Cytomegalovirus (HCMV) | British Society for Immunology"
2139:
1880:
1020:
836:
can occur intermittently, without any detectable signs or symptoms.
30:"HCMV" redirects here. For the airport with the same ICAO code, see
7941:
7872:
7621:
7268:
7010:
6866:
4142:
3076:
3057:
2058:
2041:
1172:
1081:
969:
894:
778:
404:
5368:
4393:"Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients"
1940:"Human T cell aging and the impact of persistent viral infections"
1716:
1279:
Produce minimal treatment-related side effects and adverse events.
1245:. As of 2016, the development is in clinical phase 2 trial stage.
7907:
7374:
6665:
5885:
3489:"Human Cytomegalovirus - an overview | ScienceDirect Topics"
3183:
2612:
980:
702:
polyradiculopathy, transverse myelitis, and subacute encephalitis
650:
623:
occurs when the mother has a primary infection during pregnancy.
612:
325:
3878:
3101:"Review article: cytomegalovirus and inflammatory bowel disease"
1831:
1774:
6983:
5380:
5315:
4910:
4610:"CMV | Overview | Cytomegalovirus and Congenital CMV Infection"
4391:
Ljungman, Per; Hakki, Morgan; Boeckh, Michael (February 2011).
4197:
Ross, S.A.; Novak, Z.; Pati, S.; Boppana, S.B. (October 2011).
2233:"Human Herpesvirus 5 - an overview | ScienceDirect Topics"
953:
909:
850:. One cell on the image (centre) has the characteristic large
813:
759:
670:
556:
476:
460:
298:
1586:
1335:
All three currently licensed anti-HCMV drugs target the viral
7634:
7393:
7025:
5232:
Pawelec G, McElhaney JE, Aiello AE, Derhovanessian E (2012).
3921:
3679:"Human Cytomegalovirus Latency: Approaching the Gordian Knot"
2962:
1142:
996:
988:
984:
934:
825:
821:
817:
809:
786:
480:
472:
468:
464:
435:
380:
262:
117:
5196:
3829:
3578:
Cheng J, Ke Q, Jin Z, et al. (May 2009). FrĂĽh K (ed.).
3447:
Bottieau E, Clerinx J, Van den Enden E, et al. (2006).
3446:
2504:"Human Cytomegalovirus Cell Tropism and Host Cell Receptors"
2039:
1513:
Human herpesviruses: biology, therapy, and immunoprophylaxis
770:
5320:
2678:
Snaar, S. P.; Vincent, M.; Dirks, R. W. (1 February 1999).
2444:"The Dynamics of Human Cytomegalovirus Replication in Vivo"
1370:
992:
903:
548:
491:, and also occurs through receiving transplanted organs or
4442:"Vaccine prevention of maternal cytomegalovirus infection"
3964:
3501:
3275:
3099:
Sager K, Alam S, Bond A, Chinnappan L, Probert CS (2015).
2502:
Gerna, Giuseppe; Kabanova, Anna; Lilleri, Daniele (2019).
2385:
Kahl, M.; Siegel-Axel, D.; Stenglein, S. (1 August 2000).
1937:
519:, HCMV expresses genes in a temporally controlled manner.
7838:
7720:
6860:
5234:"The impact of CMV infection on survival in older humans"
3778:
1313:
1232:
1157:
965:
898:
656:
Specific disease entities recognized in those people are
317:
271:, which in turn is a member of the viral family known as
4739:"Resistance of Human Cytomegalovirus to Antiviral Drugs"
4687:
4135:
2778:"Functional profiling of a human cytomegalovirus genome"
2384:
937:, a protein known to contribute to high blood pressure.
649:
CMV reactivation is commonly seen in people with severe
3550:
3098:
897:, or those infected with human immunodeficiency virus (
1988:
1938:
T. Fülöp; A. Larbi & G. Pawelec (September 2013).
1630:
7677:
5107:"Human cytomegalovirus resistance to antiviral drugs"
5002:
4857:
4440:
Pass RF, Zhang C, Evans A, et al. (March 2009).
4076:
2870:
1426:
International
Committee on Taxonomy of Viruses (ICTV)
592:
5358:
4196:
2871:
Carlson, A.; Norwitz, E. R.; Stiller, R. J. (2010).
2501:
1113:
but has negative test results for mononucleosis and
1109:
CMV should be suspected if a person has symptoms of
607:
that lead to congenital abnormalities. (Others are:
5104:
4390:
3781:"SARS-CoV-2, COVID-19 and the Ageing Immune System"
2727:Penfold, M. E.; Mocarski, E. S. (8 December 1997).
2309:. University of Texas Medical Branch at Galveston.
2303:Whitley, R. J.; Baron, S. (1996). "Herpesviruses".
2245:
2142:"Cytomegalovirus infection: perinatal implications"
1535:
1506:
1504:
1502:
566:within specialized viral replication compartments.
399:and represents the most significant viral cause of
3360:
2180:
1485:(4th ed.). McGraw Hill. pp. 556, 566–9.
1355:binding site of pUL54 (note: investigational drug
1191:
901:). In HIV infected persons, HCMV is considered an
438:, peaking in the late afternoon or early evening;
5453:
4578:"When & How to Wash Your Hands | Handwashing"
3727:
3143:
2677:
2556:Wathen, M. W.; Stinski, M. F. (1 February 1982).
2441:
2336:
2334:
1316:for treatment and prophylaxis of HCMV infection.
7989:
4602:
4077:Roberts ET, Haan MN, Dowd JB, Aiello AE (2010).
3571:
1499:
507:cells at a slow rate, taking about five days in
3627:
3625:
3051:
3049:
2782:Proceedings of the National Academy of Sciences
2726:
2140:Elizabeth G. Damato; Caitlin W. Winnen (2006).
1276:Provide a measurable long-term survival benefit
673:, characterised by a "pizza pie appearance" on
4961:
4439:
3005:
3003:
2331:
2288:: CS1 maint: DOI inactive as of August 2024 (
952:). Human CMV is also linked to age-associated
642:CMV infection or reactivation in people whose
277:or herpesviruses. It is also commonly called
7663:
6651:
6616:species listed below parent taxon –– Source:
5439:
4255:"CMV Infection Laboratory Testing | CDC"
3779:Bartleson JM, Radenkovic D, Verdin E (2021).
3544:
3440:
2775:
2555:
2253:Canadian Journal of General Internal Medicine
1515:. Cambridge, UK: Cambridge University Press.
979:, which is involved in the immune evasion of
960:. In persons infected with CMV about 10% of
5225:
4851:
4570:
4397:Hematology/Oncology Clinics of North America
4267:
4129:
4070:
4011:
3958:
3915:
3872:
3823:
3772:
3721:
3670:
3622:
3403:
3092:
3046:
2347:
2302:
1448:"Taxonomy browser (Human betaherpesvirus 5)"
1179:
3305:
3000:
2684:Journal of Histochemistry and Cytochemistry
1529:
1049:. Unsourced material may be challenged and
637:
585:CMV infections are most significant in the
543:for the transcription of all of its genes.
434:infection has a classic triad of symptoms:
7670:
7656:
6915:Progressive multifocal leukoencephalopathy
6658:
6644:
5446:
5432:
5325:Centers for Disease Control and Prevention
4190:
3968:Annals of the New York Academy of Sciences
3577:
3311:
3106:Alimentary Pharmacology & Therapeutics
1255:Centers for Disease Control and Prevention
1141:The enzyme-linked immunosorbent assay (or
730:(some sources reserve "mononucleosis" for
547:endothelium by interactions between their
83:
6786:Extranodal NK/T-cell lymphoma, nasal type
5130:
5038:
5028:
4979:
4887:
4877:
4762:
4713:
4465:
4416:
4360:
4293:
4230:
4199:"Diagnosis of Cytomegalovirus Infections"
4173:
4163:
4104:
3941:
3898:
3847:
3806:
3755:
3704:
3676:
3605:
3595:
3527:
3464:
3329:
3252:
3242:
3201:
3118:
3075:
2939:
2929:
2888:
2819:
2801:
2744:
2695:
2654:
2589:
2529:
2519:
2475:
2418:
2353:
2265:
2208:
2198:
2157:
2116:
2057:
2016:
2006:
1965:
1955:
1914:
1865:
1808:
1751:
1693:
1675:
1563:
1476:
1474:
1472:
1470:
1468:
1406:
1164:results unless steps are taken to remove
1069:Learn how and when to remove this message
717:
660:CMV hepatitis, which may cause fulminant
589:and in people who are immunocompromised.
5305:) is being considered for deletion. See
4342:
2497:
2495:
1080:
838:
769:
336:and possibly other malignancies such as
5153:
4858:Smith NA, Chan GC, O'Connor CM (2021).
3190:Transplant Research and Risk Management
3055:
3009:
2074:
1480:
1419:to incorporate a subfamily designation"
1412:
1269:antiviral agent, it has been shown to:
749:, type 1 diabetes, and type 2 diabetes.
14:
7990:
5061:
4787:"Previmys EPAR summary for the public"
3697:10.1146/annurev-virology-110615-042422
2877:Reviews in Obstetrics & Gynecology
1989:S. Varani & M. P. Landini (2011).
1536:Zanella M, Cordey S, Kaiser L (2020).
1465:
580:
7854:
7853:
7651:
6639:
5427:
4736:
3631:
3312:Lunn, M.; Hughes, R. (1 April 2011).
2911:
2858:"Congenital CMV Infection | CDC"
2551:
2549:
2492:
2080:
483:, or other bodily fluids. CMV can be
442:, usually exudative; and symmetrical
426:
7810:Congenital cytomegalovirus infection
7701:Congenital cytomegalovirus infection
2448:The Journal of Experimental Medicine
1590:Experimental and Molecular Pathology
1445:
1243:City of Hope National Medical Center
1156:An ELISA technique for CMV-specific
1136:
1047:adding citations to reliable sources
1014:
599:Congenital cytomegalovirus infection
330:Congenital cytomegalovirus infection
7998:Cytomegalovirus-associated diseases
6936:Subacute sclerosing panencephalitis
5331:HCMV drug resistance mutations tool
5105:C. Gilbert & G. Boivin (2005).
4558:. ClinicalTrials.gov. 12 March 2015
4310:
2344:: Omnigraphics, Inc., 2009. Online.
2081:Britt, William J. (1 August 2017).
1413:Davison, Andrew (27 January 2016).
1331:Antiviral mechanisms of HCMV drugs.
785:or glandular fever, with prolonged
24:
8008:Virus-related cutaneous conditions
4536:. ClinicalTrials.gov. 21 July 2015
4492:. ClinicalTrials.gov. 12 June 2013
4268:Revello, M. G.; Gerna, G. (2002).
3063:The Journal of Infectious Diseases
2546:
2159:10.1111/j.1552-6909.2002.tb00026.x
1326:
1322:
1198:hematopoietic stem cell transplant
745:CMV has also been associated with
593:Pregnancy and congenital infection
539:, the virus makes use of the host
25:
8024:
7679:Vertically transmitted infections
7255:Severe acute respiratory syndrome
6781:Follicular dendritic cell sarcoma
5309:to help reach a consensus. ›
5288:
5076:10.1034/j.1399-3062.1999.010204.x
4839:from the original on 27 June 2018
4823:"Approval Package for Letermovir"
4803:from the original on 27 June 2018
4514:. ClinicalTrials.gov. 8 July 2015
4203:Infectious Disorders Drug Targets
1235:cytomegalovirus vaccine ASP0113.
912:count has dropped to low levels.
605:vertically transmitted infections
385:transmitted to a developing fetus
7241:Middle East respiratory syndrome
6621:
4981:10.2165/00003495-199141010-00009
4343:Ljungman, Per (15 August 2014).
4084:American Journal of Epidemiology
3466:10.1111/j.1708-8305.2006.00049.x
2615:"Decoding Human Cytomegalovirus"
2403:10.1128/jvi.74.16.7628-7635.2000
2183:"Mechanisms of immunosenescence"
1019:
503:HCMV replicates within infected
104:
5211:10.1016/j.antiviral.2009.10.004
5190:
5147:
5098:
5055:
4996:
4955:
4904:
4815:
4779:
4730:
4681:
4662:
4632:
4548:
4526:
4504:
4482:
4433:
4384:
4336:
4261:
4247:
3495:
3481:
3397:
3354:
3269:
3218:
3177:
2956:
2905:
2864:
2850:
2836:
2769:
2720:
2671:
2606:
2435:
2378:
2296:
2239:
2225:
2174:
2133:
2033:
1982:
1931:
1874:
1825:
1768:
1391:
1192:Relevance to bone marrow donors
995:of NK cell activating receptor
983:responses. It binds to ligands
765:
454:
293:subfamily, which also includes
6840:Adult T-cell leukemia/lymphoma
6826:Splenic marginal zone lymphoma
4962:Chrisp P, Clissold SP (1991).
4616:. 17 June 2016. Archived from
4586:. 7 March 2016. Archived from
3836:European Journal of Immunology
3635:Journal of Cellular Physiology
2181:Caruso C, et al. (2009).
2146:J Obstet Gynecol Neonatal Nurs
1710:
1651:
1624:
1580:
1481:Ryan KJ, Ray CG, eds. (2004).
1439:
1415:"Rename species in the family
1208:
1085:Micrograph of CMV placentitis.
929:in humans is a major cause of
644:immune systems are compromised
555:and the endothelial-expressed
498:
395:and in communities with lower
92:CMV infection of a human lung
13:
1:
7716:Congenital varicella syndrome
5294:
5242:Current Opinion in Immunology
5168:10.1016/S0140-6736(00)02597-6
5123:10.1128/AAC.49.3.873-883.2005
4743:Clinical Microbiology Reviews
4286:10.1128/CMR.15.4.680-715.2002
4274:Clinical Microbiology Reviews
4041:10.1016/j.vaccine.2012.11.041
3375:10.1016/S0140-6736(88)92941-8
3153:Gastroenterological Endoscopy
2574:10.1128/JVI.41.2.462-477.1982
1543:Clinical Microbiology Reviews
1399:
1203:
1102:of people infected with CMV.
956:dysfunction, contributing to
628:cytomegalic inclusion disease
7045:Tropical spastic paraparesis
6950:Lymphocytic choriomeningitis
5111:Antimicrob. Agents Chemother
5009:Proc. Natl. Acad. Sci. U.S.A
4318:"United Blood Services FAQs"
4165:10.1371/journal.pone.0016103
3597:10.1371/journal.ppat.1000427
3418:10.1016/0140-6736(90)92145-8
3318:Clinical Infectious Diseases
1483:Sherris Medical Microbiology
1260:
1010:
944:, which could contribute to
7:
7696:Congenital rubella syndrome
7408:Cytomegalovirus esophagitis
7328:Human parainfluenza viruses
7001:Ramsay Hunt syndrome type 2
4706:10.1097/TP.0000000000001418
3929:Journal of General Virology
3900:10.4049/jimmunol.176.4.2645
3012:Journal of Medical Virology
2978:10.1016/j.jpeds.2014.11.002
2354:Taylor GH (February 2003).
2270:(inactive 18 August 2024).
1736:10.1016/j.ebiom.2018.03.015
1602:10.1016/j.yexmp.2011.10.011
1302:, and decreased Mg levels.
1160:is available, but may give
573:for a timely entrance into
449:
375:in the general population.
10:
8029:
4879:10.1186/s12985-021-01674-1
4215:10.2174/187152611797636703
3799:10.1038/s43587-021-00114-7
3728:Nikolich-Zugich J (2008).
3453:Journal of Travel Medicine
2697:10.1177/002215549904700213
1899:10.1038/s41388-023-02709-3
1850:10.1038/s41417-024-00767-7
1793:10.1038/s41388-023-02813-4
1248:
1212:
596:
533:transcriptional regulation
29:
7931:
7862:
7818:
7797:
7766:
7685:
7611:
7587:
7495:
7418:
7373:
7362:
7191:
7153:
7132:
7100:
7072:Cytomegalovirus retinitis
7055:
7009:
6888:
6877:
6850:
6677:
6611:
6528:
6510:
6465:
6440:
6380:
6320:
6302:
6268:
6219:
6189:
6159:
6129:
6059:
6048:
5934:
5844:
5819:
5774:
5749:
5727:
5705:
5667:
5637:
5602:
5572:
5568:
5557:
5531:
5513:
5509:
5498:
5464:
5362:
5255:10.1016/j.coi.2012.04.002
4794:European Medicines Agency
4409:10.1016/j.hoc.2010.11.011
3735:Nature Reviews Immunology
3684:Annual Review of Virology
3156:. Thieme. pp. 490–.
2966:The Journal of Pediatrics
1310:European Medicines Agency
1308:has been approved by the
1180:Relevance to blood donors
1096:polymerase chain reaction
893:recipients, persons with
667:cytomegalovirus retinitis
621:Congenital HCMV infection
551:-containing cell surface
303:double-stranded DNA virus
231:
224:
99:
91:
82:
75:
61:
49:
44:
7174:Infectious mononucleosis
6991:Chandipura vesiculovirus
6821:Hepatocellular carcinoma
6766:Nasopharyngeal carcinoma
6699:Hepatocellular carcinoma
5307:templates for discussion
4669:Cytogam Prescribing Info
3291:10.1093/infdis/121.6.608
2267:10.22374/cjgim.v13i3.258
1957:10.3389/fimmu.2013.00271
1111:infectious mononucleosis
783:infectious mononucleosis
638:Immunocompromised adults
334:mucoepidermoid carcinoma
7933:Human betaherpesvirus 5
7894:Human betaherpesvirus 5
7706:Neonatal herpes simplex
6970:Encephalitis lethargica
6671:viral systemic diseases
5312:Human betaherpesvirus 5
5030:10.1073/pnas.83.22.8769
4644:National CMV Foundation
3989:10.1196/annals.1354.009
2803:10.1073/pnas.2334032100
2639:10.1126/science.1227919
2521:10.3390/vaccines7030070
1944:Frontiers in Immunology
1677:10.3390/cancers15204994
1215:Cytomegalovirus vaccine
975:CMV encodes a protein,
756:cardiovascular diseases
747:Guillain–Barré syndrome
681:cytomegalovirus colitis
432:Human betaherpesvirus 5
413:intellectual disability
359:and almost 100% in the
246:Human betaherpesvirus 5
217:Human betaherpesvirus 5
77:Human betaherpesvirus 5
66:Human betaherpesvirus 5
7342:Human orthopneumovirus
6996:Herpesviral meningitis
6957:Arbovirus encephalitis
5336:9 January 2016 at the
3943:10.1099/vir.0.036004-0
3849:10.1002/immu.200390022
3244:10.1186/1743-422X-5-47
2746:10.1006/viro.1997.8848
2200:10.1186/1742-4933-6-10
1384:9 January 2016 at the
1332:
1086:
908:, indicating that the
863:
774:
718:Immunocompetent adults
391:is more widespread in
369:adaptive host immunity
287:, HCMV belongs to the
6800:Merkel-cell carcinoma
5352:NCBI Taxonomy Browser
5321:Cytomegalovirus (CMV)
4674:26 April 2012 at the
4458:10.1056/NEJMoa0804749
3886:Journal of Immunology
2912:Britt, W. J. (2018).
2460:10.1084/jem.190.2.177
2008:10.1186/2042-4280-2-6
1379:web-based search tool
1330:
1084:
916:Lytically replicating
889:individuals, such as
842:
773:
683:(inflammation of the
669:(inflammation of the
521:Immediate early genes
409:learning disabilities
251:human cytomegalovirus
45:Human cytomegalovirus
18:Human cytomegalovirus
7445:Adenovirus infection
6909:Human polyomavirus 2
6738:Oropharyngeal cancer
5064:Transpl. Infect. Dis
4755:10.1128/CMR.12.2.286
4590:on 13 September 2017
3936:(Pt 12): 2746–2756.
3520:10.1136/jcp.53.8.612
3203:10.2147/TRRM.S366213
2306:Medical Microbiology
2101:10.1128/JVI.02392-16
1556:10.1128/CMR.00027-20
1452:www.ncbi.nlm.nih.gov
1266:Hyperimmune globulin
1043:improve this section
946:chronic inflammation
918:viruses disrupt the
736:cervical lymph nodes
485:transmitted sexually
397:socioeconomic status
393:developing countries
101:Virus classification
7864:Human herpesvirus 5
7736:Congenital syphilis
7031:Post-polio syndrome
6667:Infectious diseases
5501:Malacoherpesviridae
5346:Human herpesvirus 5
5021:1986PNAS...83.8769B
4925:1992Natur.358..162S
4156:2011PLoSO...616103S
3981:2006NYASA1067...56P
2794:2003PNAS..10014223D
2788:(24): 14223–14228.
2631:2012Sci...338.1088S
2625:(6110): 1088–1093.
2562:Journal of Virology
2391:Journal of Virology
2088:Journal of Virology
1838:Cancer Gene Therapy
1151:latex agglutination
942:cellular senescence
906:-defining infection
603:HCMV is one of the
581:At-risk populations
320:-infected persons,
261:), is a species of
235:Human herpesvirus 5
7164:Epstein–Barr virus
7134:Respiratory system
6771:Burkitt's lymphoma
5327:(CDC). 22 May 2009
5199:Antiviral Research
4737:Erice, A. (1999).
4650:on 16 October 2017
4640:"CMV Transmission"
4620:on 16 October 2017
4362:10.1093/cid/ciu364
4257:. 3 December 2021.
4097:10.1093/aje/kwq177
3677:Goodrum F (2016).
3331:10.1093/cid/cir082
2860:. 3 December 2021.
1333:
1196:During allogeneic
1115:Epstein–Barr virus
1087:
864:
775:
732:Epstein–Barr virus
511:. It also infects
493:blood transfusions
427:Signs and symptoms
192:Orthoherpesviridae
56:Infectious disease
8003:Betaherpesvirinae
7985:
7984:
7856:Taxon identifiers
7847:
7846:
7645:
7644:
7607:
7606:
7358:
7357:
7289:Influenza virus A
7206:Human coronavirus
7096:
7095:
7086:Herpes of the eye
6633:
6632:
6607:
6606:
6603:
6602:
6323:Lymphocryptovirus
6296:
6295:
6264:
6263:
6044:
6043:
5743:
5742:
5721:
5720:
5701:
5700:
5697:
5696:
5560:Alloherpesviridae
5553:
5552:
5549:
5548:
5466:Higher taxonomy:
5421:
5420:
5280:on 19 April 2018.
5162:(9230): 609–610.
5015:(22): 8769–8773.
4919:(6382): 162–164.
4066:on 19 April 2018.
3648:10.1002/jcp.26956
3642:(12): 9121–9135.
3412:(8716): 644–648.
3163:978-3-13-125852-6
3120:10.1111/apt.13124
3024:10.1002/jmv.24450
2972:(4): 834–839.e1.
2931:10.3390/v10080405
2397:(16): 7628–7635.
2356:"Cytomegalovirus"
2095:(15): e02392–16.
2046:Clin. Infect. Dis
1893:(24): 2031–2045.
1787:(41): 3047–3061.
1522:978-0-521-82714-0
1492:978-0-8385-8529-0
1166:rheumatoid factor
1137:Serologic testing
1079:
1078:
1071:
968:memory T-cells.
940:Human CMV causes
887:immunocompromised
834:shedding of virus
314:immunocompromised
295:cytomegaloviruses
290:Betaherpesvirinae
242:
241:
71:
70:
39:Medical condition
16:(Redirected from
8020:
7978:
7977:
7965:
7964:
7952:
7951:
7950:
7924:
7923:
7911:
7910:
7898:
7897:
7896:
7883:
7882:
7881:
7851:
7850:
7672:
7665:
7658:
7649:
7648:
7371:
7370:
7366:digestive system
7283:Orthomyxoviridae
7249:SARS coronavirus
7235:MERS coronavirus
7151:
7150:
6963:Orthomyxoviridae
6886:
6885:
6852:Immune disorders
6776:Hodgkin lymphoma
6752:Kaposi's sarcoma
6660:
6653:
6646:
6637:
6636:
6625:
6300:
6299:
6294:
6288:
6282:
6277:
6276:
6057:
6056:
5747:
5746:
5741:
5736:
5735:
5725:
5724:
5719:
5714:
5713:
5570:
5569:
5566:
5565:
5511:
5510:
5507:
5506:
5454:Taxonomy of the
5448:
5441:
5434:
5425:
5424:
5360:
5359:
5355:
5282:
5281:
5279:
5273:. Archived from
5238:
5229:
5223:
5222:
5194:
5188:
5187:
5151:
5145:
5144:
5134:
5102:
5096:
5095:
5059:
5053:
5052:
5042:
5032:
5000:
4994:
4993:
4983:
4959:
4953:
4952:
4933:10.1038/358162a0
4908:
4902:
4901:
4891:
4881:
4865:Virology Journal
4855:
4849:
4848:
4846:
4844:
4838:
4827:
4819:
4813:
4812:
4810:
4808:
4802:
4791:
4783:
4777:
4776:
4766:
4734:
4728:
4727:
4717:
4685:
4679:
4666:
4660:
4659:
4657:
4655:
4646:. Archived from
4636:
4630:
4629:
4627:
4625:
4606:
4600:
4599:
4597:
4595:
4574:
4568:
4567:
4565:
4563:
4552:
4546:
4545:
4543:
4541:
4530:
4524:
4523:
4521:
4519:
4508:
4502:
4501:
4499:
4497:
4486:
4480:
4479:
4469:
4437:
4431:
4430:
4420:
4388:
4382:
4381:
4379:
4377:
4364:
4340:
4334:
4333:
4331:
4329:
4320:. Archived from
4314:
4308:
4307:
4297:
4265:
4259:
4258:
4251:
4245:
4244:
4234:
4194:
4188:
4187:
4177:
4167:
4133:
4127:
4126:
4108:
4074:
4068:
4067:
4065:
4059:. Archived from
4024:
4015:
4009:
4008:
3962:
3956:
3955:
3945:
3919:
3913:
3912:
3902:
3893:(4): 2645–2653.
3876:
3870:
3869:
3851:
3827:
3821:
3820:
3810:
3776:
3770:
3769:
3759:
3725:
3719:
3718:
3708:
3674:
3668:
3667:
3629:
3620:
3619:
3609:
3599:
3575:
3569:
3568:
3553:Mt. Sinai J. Med
3548:
3542:
3541:
3531:
3499:
3493:
3492:
3485:
3479:
3478:
3468:
3444:
3438:
3437:
3401:
3395:
3394:
3358:
3352:
3351:
3333:
3309:
3303:
3302:
3273:
3267:
3266:
3256:
3246:
3231:Virology Journal
3222:
3216:
3215:
3205:
3181:
3175:
3174:
3172:
3170:
3147:
3141:
3140:
3122:
3096:
3090:
3089:
3079:
3070:(9): 1273–1275.
3056:Cook CH (2007).
3053:
3044:
3043:
3007:
2998:
2997:
2960:
2954:
2953:
2943:
2933:
2909:
2903:
2902:
2892:
2868:
2862:
2861:
2854:
2848:
2847:
2840:
2834:
2833:
2823:
2805:
2773:
2767:
2766:
2748:
2724:
2718:
2717:
2699:
2675:
2669:
2668:
2658:
2610:
2604:
2603:
2593:
2553:
2544:
2543:
2533:
2523:
2499:
2490:
2489:
2479:
2439:
2433:
2432:
2422:
2382:
2376:
2375:
2360:Am Fam Physician
2351:
2345:
2338:
2329:
2328:
2300:
2294:
2293:
2287:
2279:
2269:
2243:
2237:
2236:
2229:
2223:
2222:
2212:
2202:
2178:
2172:
2171:
2161:
2137:
2131:
2130:
2120:
2078:
2072:
2071:
2061:
2037:
2031:
2030:
2020:
2010:
1986:
1980:
1979:
1969:
1959:
1935:
1929:
1928:
1918:
1878:
1872:
1871:
1869:
1844:(7): 1070–1080.
1829:
1823:
1822:
1812:
1772:
1766:
1765:
1755:
1714:
1708:
1707:
1697:
1679:
1655:
1649:
1648:
1633:Cancer Treat Rep
1628:
1622:
1621:
1584:
1578:
1577:
1567:
1550:(4): e00027-20.
1533:
1527:
1526:
1508:
1497:
1496:
1478:
1463:
1462:
1460:
1458:
1443:
1437:
1436:
1434:
1432:
1423:
1410:
1147:hemagglutination
1074:
1067:
1063:
1060:
1054:
1023:
1015:
958:immunosenescence
891:organ transplant
872:H&E staining
868:inclusion bodies
587:perinatal period
383:most frequently
322:organ transplant
109:
108:
87:
73:
72:
42:
41:
27:Species of virus
21:
8028:
8027:
8023:
8022:
8021:
8019:
8018:
8017:
7988:
7987:
7986:
7981:
7973:
7968:
7960:
7955:
7946:
7945:
7940:
7927:
7919:
7914:
7906:
7901:
7892:
7891:
7886:
7877:
7876:
7871:
7858:
7848:
7843:
7814:
7793:
7762:
7681:
7676:
7646:
7641:
7603:
7583:
7491:
7465:Gastroenteritis
7423:
7420:Gastroenteritis
7414:
7402:Cytomegalovirus
7365:
7354:
7322:Paramyxoviridae
7311:Avian influenza
7187:
7182:Cytomegalovirus
7146:viral pneumonia
7144:
7141:nasopharyngitis
7140:
7137:
7128:
7092:
7066:Cytomegalovirus
7051:
7005:
6893:
6880:
6873:
6846:
6713:Cervical cancer
6673:
6664:
6634:
6629:
6599:
6524:
6506:
6461:
6436:
6376:
6316:
6290:
6289:
6284:
6283:
6278:
6275:
6274:
6260:
6215:
6185:
6155:
6132:Muromegalovirus
6125:
6062:Cytomegalovirus
6040:
5930:
5840:
5815:
5770:
5737:
5734:
5733:
5715:
5712:
5711:
5693:
5663:
5633:
5598:
5545:
5527:
5494:
5460:
5452:
5422:
5417:
5416:
5371:
5342:
5338:Wayback Machine
5310:
5291:
5286:
5285:
5277:
5236:
5230:
5226:
5195:
5191:
5152:
5148:
5103:
5099:
5060:
5056:
5001:
4997:
4960:
4956:
4909:
4905:
4856:
4852:
4842:
4840:
4836:
4825:
4821:
4820:
4816:
4806:
4804:
4800:
4789:
4785:
4784:
4780:
4735:
4731:
4700:(10): e74–e80.
4694:Transplantation
4686:
4682:
4676:Wayback Machine
4667:
4663:
4653:
4651:
4638:
4637:
4633:
4623:
4621:
4608:
4607:
4603:
4593:
4591:
4576:
4575:
4571:
4561:
4559:
4554:
4553:
4549:
4539:
4537:
4532:
4531:
4527:
4517:
4515:
4510:
4509:
4505:
4495:
4493:
4488:
4487:
4483:
4446:N. Engl. J. Med
4438:
4434:
4389:
4385:
4375:
4373:
4349:Clin Infect Dis
4341:
4337:
4327:
4325:
4316:
4315:
4311:
4266:
4262:
4253:
4252:
4248:
4195:
4191:
4134:
4130:
4075:
4071:
4063:
4022:
4016:
4012:
3963:
3959:
3920:
3916:
3877:
3873:
3828:
3824:
3777:
3773:
3748:10.1038/nri2318
3726:
3722:
3675:
3671:
3630:
3623:
3590:(5): e1000427.
3576:
3572:
3549:
3545:
3508:J. Clin. Pathol
3500:
3496:
3487:
3486:
3482:
3445:
3441:
3402:
3398:
3359:
3355:
3310:
3306:
3274:
3270:
3223:
3219:
3182:
3178:
3168:
3166:
3164:
3148:
3144:
3097:
3093:
3054:
3047:
3008:
3001:
2961:
2957:
2910:
2906:
2869:
2865:
2856:
2855:
2851:
2842:
2841:
2837:
2774:
2770:
2725:
2721:
2676:
2672:
2611:
2607:
2554:
2547:
2500:
2493:
2440:
2436:
2383:
2379:
2352:
2348:
2340:Larsen, Laura.
2339:
2332:
2317:
2301:
2297:
2281:
2280:
2244:
2240:
2231:
2230:
2226:
2179:
2175:
2138:
2134:
2079:
2075:
2038:
2034:
1987:
1983:
1978:. article: 271.
1936:
1932:
1879:
1875:
1830:
1826:
1773:
1769:
1715:
1711:
1656:
1652:
1629:
1625:
1585:
1581:
1534:
1530:
1523:
1509:
1500:
1493:
1479:
1466:
1456:
1454:
1444:
1440:
1430:
1428:
1421:
1411:
1407:
1402:
1394:
1386:Wayback Machine
1362:drug resistance
1325:
1323:Drug resistance
1301:
1263:
1251:
1229:Astellas Pharma
1217:
1211:
1206:
1194:
1182:
1168:or most of the
1139:
1075:
1064:
1058:
1055:
1040:
1024:
1013:
931:atherosclerosis
768:
720:
640:
601:
595:
583:
529:DNA replication
501:
457:
452:
429:
338:prostate cancer
326:newborn infants
324:recipients, or
310:salivary glands
268:Cytomegalovirus
220:
204:Cytomegalovirus
103:
40:
35:
28:
23:
22:
15:
12:
11:
5:
8026:
8016:
8015:
8013:Viral diseases
8010:
8005:
8000:
7983:
7982:
7980:
7979:
7966:
7953:
7937:
7935:
7929:
7928:
7926:
7925:
7912:
7899:
7884:
7868:
7866:
7860:
7859:
7845:
7844:
7842:
7841:
7836:
7831:
7825:
7823:
7816:
7815:
7813:
7812:
7807:
7801:
7799:
7798:Late pregnancy
7795:
7794:
7792:
7791:
7786:
7781:
7776:
7770:
7768:
7764:
7763:
7761:
7760:
7755:
7753:transplacental
7750:
7749:
7748:
7740:
7739:
7738:
7730:
7729:
7728:
7723:
7718:
7713:
7708:
7703:
7698:
7689:
7687:
7683:
7682:
7675:
7674:
7667:
7660:
7652:
7643:
7642:
7640:
7639:
7638:
7637:
7625:
7617:
7615:
7609:
7608:
7605:
7604:
7602:
7601:
7593:
7591:
7585:
7584:
7582:
7581:
7569:
7557:
7545:
7533:
7526:
7520:
7519:
7507:
7501:
7499:
7493:
7492:
7490:
7489:
7482:
7475:
7468:
7456:
7450:
7449:
7448:
7447:
7435:
7429:
7427:
7416:
7415:
7413:
7412:
7411:
7410:
7398:
7397:
7396:
7383:
7381:
7368:
7360:
7359:
7356:
7355:
7353:
7352:
7345:
7338:
7337:
7336:
7316:
7315:
7314:
7313:
7274:
7273:
7272:
7271:
7259:
7258:
7257:
7245:
7244:
7243:
7231:
7230:
7229:
7197:
7195:
7189:
7188:
7186:
7185:
7178:
7177:
7176:
7159:
7157:
7148:
7130:
7129:
7127:
7126:
7125:
7124:
7119:
7106:
7104:
7102:Cardiovascular
7098:
7097:
7094:
7093:
7091:
7090:
7089:
7088:
7076:
7075:
7074:
7061:
7059:
7053:
7052:
7050:
7049:
7048:
7047:
7035:
7034:
7033:
7028:
7015:
7013:
7007:
7006:
7004:
7003:
6998:
6993:
6988:
6987:
6986:
6974:
6973:
6972:
6959:
6954:
6953:
6952:
6940:
6939:
6938:
6926:
6920:
6919:
6918:
6917:
6905:
6899:
6897:
6883:
6881:nervous system
6875:
6874:
6872:
6871:
6870:
6869:
6856:
6854:
6848:
6847:
6845:
6844:
6843:
6842:
6830:
6829:
6828:
6823:
6811:
6805:
6804:
6803:
6802:
6790:
6789:
6788:
6783:
6778:
6773:
6768:
6756:
6755:
6754:
6742:
6741:
6740:
6735:
6733:Vaginal cancer
6730:
6725:
6720:
6715:
6703:
6702:
6701:
6689:
6683:
6681:
6675:
6674:
6663:
6662:
6655:
6648:
6640:
6631:
6630:
6612:
6609:
6608:
6605:
6604:
6601:
6600:
6598:
6597:
6592:
6587:
6582:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6542:
6536:
6534:
6526:
6525:
6523:
6522:
6518:
6516:
6508:
6507:
6505:
6504:
6499:
6494:
6489:
6484:
6479:
6473:
6471:
6463:
6462:
6460:
6459:
6454:
6448:
6446:
6438:
6437:
6435:
6434:
6429:
6424:
6419:
6414:
6409:
6404:
6399:
6394:
6388:
6386:
6378:
6377:
6375:
6374:
6369:
6364:
6359:
6354:
6349:
6344:
6339:
6334:
6328:
6326:
6318:
6317:
6315:
6314:
6310:
6308:
6297:
6266:
6265:
6262:
6261:
6259:
6258:
6253:
6248:
6243:
6238:
6233:
6227:
6225:
6217:
6216:
6214:
6213:
6208:
6203:
6197:
6195:
6187:
6186:
6184:
6183:
6178:
6173:
6167:
6165:
6157:
6156:
6154:
6153:
6148:
6143:
6137:
6135:
6127:
6126:
6124:
6123:
6118:
6113:
6108:
6103:
6098:
6093:
6088:
6083:
6078:
6073:
6067:
6065:
6054:
6046:
6045:
6042:
6041:
6039:
6038:
6033:
6028:
6023:
6018:
6013:
6008:
6003:
5998:
5993:
5988:
5983:
5978:
5973:
5968:
5963:
5958:
5953:
5948:
5942:
5940:
5937:Varicellovirus
5932:
5931:
5929:
5928:
5923:
5918:
5913:
5908:
5903:
5898:
5893:
5888:
5883:
5878:
5873:
5868:
5863:
5858:
5852:
5850:
5842:
5841:
5839:
5838:
5833:
5827:
5825:
5817:
5816:
5814:
5813:
5808:
5803:
5798:
5793:
5788:
5782:
5780:
5772:
5771:
5769:
5768:
5763:
5757:
5755:
5744:
5722:
5703:
5702:
5699:
5698:
5695:
5694:
5692:
5691:
5686:
5681:
5675:
5673:
5665:
5664:
5662:
5661:
5656:
5651:
5645:
5643:
5635:
5634:
5632:
5631:
5626:
5621:
5616:
5610:
5608:
5600:
5599:
5597:
5596:
5591:
5586:
5580:
5578:
5563:
5555:
5554:
5551:
5550:
5547:
5546:
5544:
5543:
5539:
5537:
5529:
5528:
5526:
5525:
5521:
5519:
5504:
5496:
5495:
5487:Herviviricetes
5475:Heunggongvirae
5465:
5462:
5461:
5451:
5450:
5443:
5436:
5428:
5419:
5418:
5415:
5414:
5403:
5388:
5372:
5367:
5366:
5364:
5363:Classification
5357:
5356:
5340:
5328:
5318:
5290:
5289:External links
5287:
5284:
5283:
5249:(4): 507–511.
5224:
5189:
5146:
5117:(3): 873–883.
5097:
5070:(2): 105–114.
5054:
4995:
4974:(1): 104–129.
4954:
4903:
4850:
4814:
4778:
4749:(2): 286–297.
4729:
4680:
4678:CSL Behring AG
4661:
4631:
4601:
4569:
4547:
4525:
4503:
4481:
4452:(12): 1191–9.
4432:
4403:(1): 151–169.
4383:
4335:
4324:on 19 May 2007
4309:
4280:(4): 680–715.
4260:
4246:
4209:(5): 466–474.
4189:
4128:
4091:(4): 363–371.
4069:
4035:(4): 685–690.
4010:
3957:
3914:
3871:
3842:(1): 194–203.
3822:
3793:(9): 769–782.
3771:
3742:(7): 512–522.
3720:
3691:(1): 333–357.
3669:
3621:
3570:
3543:
3494:
3480:
3439:
3396:
3353:
3324:(7): 845–847.
3304:
3279:J. Infect. Dis
3268:
3217:
3176:
3162:
3142:
3113:(8): 725–733.
3091:
3077:10.1086/522433
3045:
3018:(7): 1103–12.
2999:
2955:
2904:
2883:(4): 172–179.
2863:
2849:
2835:
2768:
2719:
2690:(2): 245–254.
2670:
2605:
2568:(2): 462–477.
2545:
2491:
2454:(2): 177–182.
2434:
2377:
2346:
2330:
2315:
2295:
2238:
2224:
2173:
2132:
2073:
2059:10.1086/508173
2052:(9): 1143–51.
2032:
1981:
1930:
1873:
1824:
1767:
1709:
1650:
1623:
1579:
1528:
1521:
1498:
1491:
1464:
1438:
1404:
1403:
1401:
1398:
1393:
1390:
1337:DNA polymerase
1324:
1321:
1299:
1288:Valganciclovir
1281:
1280:
1277:
1274:
1262:
1259:
1250:
1247:
1213:Main article:
1210:
1207:
1205:
1202:
1193:
1190:
1186:blood donation
1181:
1178:
1162:false-positive
1138:
1135:
1077:
1076:
1027:
1025:
1018:
1012:
1009:
962:memory T cells
767:
764:
751:
750:
743:
719:
716:
708:valganciclovir
704:
703:
700:
694:
688:
678:
675:ophthalmoscopy
664:
639:
636:
617:herpes simplex
597:Main article:
594:
591:
582:
579:
541:RNA polymerase
537:DNA polymerase
500:
497:
456:
453:
451:
448:
428:
425:
377:Seroprevalence
346:ovarian cancer
249:, also called
240:
239:
238:
237:
229:
228:
222:
221:
214:
212:
208:
207:
200:
196:
195:
188:
184:
183:
176:
172:
171:
168:Herviviricetes
164:
160:
159:
152:
148:
147:
144:Heunggongvirae
140:
136:
135:
128:
121:
120:
115:
111:
110:
97:
96:
89:
88:
80:
79:
69:
68:
63:
59:
58:
53:
47:
46:
38:
26:
9:
6:
4:
3:
2:
8025:
8014:
8011:
8009:
8006:
8004:
8001:
7999:
7996:
7995:
7993:
7976:
7971:
7967:
7963:
7958:
7954:
7949:
7943:
7939:
7938:
7936:
7934:
7930:
7922:
7917:
7913:
7909:
7904:
7900:
7895:
7889:
7885:
7880:
7874:
7870:
7869:
7867:
7865:
7861:
7857:
7852:
7840:
7837:
7835:
7832:
7830:
7829:Breastfeeding
7827:
7826:
7824:
7822:
7821:breastfeeding
7817:
7811:
7808:
7806:
7803:
7802:
7800:
7796:
7790:
7787:
7785:
7782:
7780:
7777:
7775:
7774:transcervical
7772:
7771:
7769:
7765:
7759:
7758:TORCH complex
7756:
7754:
7751:
7747:
7746:Toxoplasmosis
7744:
7743:
7741:
7737:
7734:
7733:
7731:
7727:
7726:Fifth disease
7724:
7722:
7719:
7717:
7714:
7712:
7709:
7707:
7704:
7702:
7699:
7697:
7694:
7693:
7691:
7690:
7688:
7684:
7680:
7673:
7668:
7666:
7661:
7659:
7654:
7653:
7650:
7636:
7633:
7632:
7631:
7630:
7626:
7624:
7623:
7619:
7618:
7616:
7614:
7610:
7600:
7599:
7595:
7594:
7592:
7590:
7586:
7579:
7575:
7574:
7570:
7567:
7563:
7562:
7558:
7555:
7551:
7550:
7546:
7543:
7539:
7538:
7534:
7532:
7531:
7527:
7525:
7522:
7521:
7517:
7513:
7512:
7508:
7506:
7503:
7502:
7500:
7498:
7494:
7488:
7487:
7483:
7481:
7480:
7476:
7474:
7473:
7469:
7466:
7462:
7461:
7457:
7455:
7452:
7451:
7446:
7443:
7442:
7441:
7440:
7436:
7434:
7431:
7430:
7428:
7426:
7421:
7417:
7409:
7406:
7405:
7404:
7403:
7399:
7395:
7392:
7391:
7390:
7389:
7385:
7384:
7382:
7380:
7376:
7372:
7369:
7367:
7361:
7351:
7350:
7346:
7344:
7343:
7339:
7335:
7334:Parainfluenza
7332:
7331:
7330:
7329:
7324:
7323:
7318:
7317:
7312:
7308:
7305:
7304:
7303:
7302:
7298:
7294:
7290:
7285:
7284:
7279:
7276:
7275:
7270:
7267:
7266:
7265:
7264:
7260:
7256:
7253:
7252:
7251:
7250:
7246:
7242:
7239:
7238:
7237:
7236:
7232:
7228:
7225:
7224:
7223:
7222:
7218:
7214:
7210:
7207:
7202:
7199:
7198:
7196:
7194:
7190:
7184:
7183:
7179:
7175:
7171:
7170:EBV infection
7168:
7167:
7166:
7165:
7161:
7160:
7158:
7156:
7152:
7149:
7147:
7142:
7135:
7131:
7123:
7120:
7118:
7115:
7114:
7113:
7112:
7108:
7107:
7105:
7103:
7099:
7087:
7084:
7083:
7082:
7081:
7077:
7073:
7070:
7069:
7068:
7067:
7063:
7062:
7060:
7058:
7054:
7046:
7043:
7042:
7041:
7040:
7036:
7032:
7029:
7027:
7026:Poliomyelitis
7024:
7023:
7022:
7021:
7017:
7016:
7014:
7012:
7008:
7002:
6999:
6997:
6994:
6992:
6989:
6985:
6982:
6981:
6980:
6979:
6975:
6971:
6968:
6967:
6965:
6964:
6960:
6958:
6955:
6951:
6948:
6947:
6946:
6945:
6941:
6937:
6934:
6933:
6932:
6931:
6927:
6925:
6922:
6921:
6916:
6913:
6912:
6911:
6910:
6906:
6904:
6901:
6900:
6898:
6896:
6891:
6887:
6884:
6882:
6876:
6868:
6865:
6864:
6863:
6862:
6858:
6857:
6855:
6853:
6849:
6841:
6838:
6837:
6836:
6835:
6831:
6827:
6824:
6822:
6819:
6818:
6817:
6816:
6812:
6810:
6807:
6806:
6801:
6798:
6797:
6796:
6795:
6791:
6787:
6784:
6782:
6779:
6777:
6774:
6772:
6769:
6767:
6764:
6763:
6762:
6761:
6757:
6753:
6750:
6749:
6748:
6747:
6743:
6739:
6736:
6734:
6731:
6729:
6728:Vulvar cancer
6726:
6724:
6723:Penile cancer
6721:
6719:
6716:
6714:
6711:
6710:
6709:
6708:
6704:
6700:
6697:
6696:
6695:
6694:
6690:
6688:
6685:
6684:
6682:
6680:
6676:
6672:
6668:
6661:
6656:
6654:
6649:
6647:
6642:
6641:
6638:
6628:
6624:
6619:
6615:
6610:
6596:
6593:
6591:
6588:
6586:
6583:
6581:
6578:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6537:
6535:
6533:
6532:
6527:
6520:
6519:
6517:
6515:
6514:
6509:
6503:
6500:
6498:
6495:
6493:
6490:
6488:
6485:
6483:
6480:
6478:
6475:
6474:
6472:
6470:
6469:
6464:
6458:
6455:
6453:
6450:
6449:
6447:
6445:
6444:
6439:
6433:
6430:
6428:
6425:
6423:
6420:
6418:
6415:
6413:
6410:
6408:
6405:
6403:
6400:
6398:
6395:
6393:
6390:
6389:
6387:
6385:
6384:
6379:
6373:
6370:
6368:
6365:
6363:
6360:
6358:
6355:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6333:
6330:
6329:
6327:
6325:
6324:
6319:
6312:
6311:
6309:
6307:
6306:
6301:
6298:
6293:
6287:
6281:
6273:
6272:
6267:
6257:
6254:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6228:
6226:
6224:
6223:
6218:
6212:
6209:
6207:
6204:
6202:
6199:
6198:
6196:
6194:
6193:
6188:
6182:
6179:
6177:
6174:
6172:
6169:
6168:
6166:
6164:
6163:
6162:Proboscivirus
6158:
6152:
6149:
6147:
6144:
6142:
6139:
6138:
6136:
6134:
6133:
6128:
6122:
6119:
6117:
6114:
6112:
6109:
6107:
6104:
6102:
6099:
6097:
6094:
6092:
6089:
6087:
6084:
6082:
6079:
6077:
6074:
6072:
6069:
6068:
6066:
6064:
6063:
6058:
6055:
6053:
6052:
6047:
6037:
6034:
6032:
6029:
6027:
6024:
6022:
6019:
6017:
6014:
6012:
6009:
6007:
6004:
6002:
5999:
5997:
5994:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5972:
5969:
5967:
5964:
5962:
5959:
5957:
5954:
5952:
5949:
5947:
5944:
5943:
5941:
5939:
5938:
5933:
5927:
5924:
5922:
5919:
5917:
5914:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5879:
5877:
5874:
5872:
5869:
5867:
5864:
5862:
5859:
5857:
5854:
5853:
5851:
5849:
5848:
5843:
5837:
5834:
5832:
5829:
5828:
5826:
5824:
5823:
5818:
5812:
5809:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5783:
5781:
5779:
5778:
5773:
5767:
5764:
5762:
5759:
5758:
5756:
5754:
5753:
5748:
5745:
5740:
5732:
5731:
5726:
5723:
5718:
5710:
5709:
5708:Herpesviridae
5704:
5690:
5687:
5685:
5682:
5680:
5677:
5676:
5674:
5672:
5671:
5666:
5660:
5657:
5655:
5652:
5650:
5647:
5646:
5644:
5642:
5641:
5640:Ictalurivirus
5636:
5630:
5627:
5625:
5622:
5620:
5617:
5615:
5612:
5611:
5609:
5607:
5606:
5601:
5595:
5592:
5590:
5587:
5585:
5582:
5581:
5579:
5577:
5576:
5575:Batrachovirus
5571:
5567:
5564:
5562:
5561:
5556:
5541:
5540:
5538:
5536:
5535:
5530:
5523:
5522:
5520:
5518:
5517:
5512:
5508:
5505:
5503:
5502:
5497:
5493:
5492:Herpesvirales
5489:
5488:
5483:
5482:
5481:Peploviricota
5477:
5476:
5471:
5470:
5469:Duplodnaviria
5463:
5459:
5458:
5457:Herpesvirales
5449:
5444:
5442:
5437:
5435:
5430:
5429:
5426:
5413:
5409:
5408:
5404:
5402:
5398:
5397:
5393:
5389:
5387:
5383:
5382:
5378:
5374:
5373:
5370:
5365:
5361:
5353:
5349:
5347:
5341:
5339:
5335:
5332:
5329:
5326:
5322:
5319:
5317:
5313:
5308:
5304:
5303:
5298:
5293:
5292:
5276:
5272:
5268:
5264:
5260:
5256:
5252:
5248:
5244:
5243:
5235:
5228:
5220:
5216:
5212:
5208:
5205:(2): 318–27.
5204:
5200:
5193:
5185:
5181:
5177:
5173:
5169:
5165:
5161:
5157:
5150:
5142:
5138:
5133:
5128:
5124:
5120:
5116:
5112:
5108:
5101:
5093:
5089:
5085:
5081:
5077:
5073:
5069:
5065:
5058:
5050:
5046:
5041:
5036:
5031:
5026:
5022:
5018:
5014:
5010:
5006:
4999:
4991:
4987:
4982:
4977:
4973:
4969:
4965:
4958:
4950:
4946:
4942:
4938:
4934:
4930:
4926:
4922:
4918:
4914:
4907:
4899:
4895:
4890:
4885:
4880:
4875:
4871:
4867:
4866:
4861:
4854:
4835:
4831:
4824:
4818:
4799:
4795:
4788:
4782:
4774:
4770:
4765:
4760:
4756:
4752:
4748:
4744:
4740:
4733:
4725:
4721:
4716:
4711:
4707:
4703:
4699:
4695:
4691:
4684:
4677:
4673:
4670:
4665:
4649:
4645:
4641:
4635:
4619:
4615:
4611:
4605:
4589:
4585:
4584:
4579:
4573:
4557:
4551:
4535:
4529:
4513:
4507:
4491:
4485:
4477:
4473:
4468:
4463:
4459:
4455:
4451:
4447:
4443:
4436:
4428:
4424:
4419:
4414:
4410:
4406:
4402:
4398:
4394:
4387:
4372:
4368:
4363:
4358:
4355:(4): 473–81.
4354:
4350:
4346:
4339:
4323:
4319:
4313:
4305:
4301:
4296:
4291:
4287:
4283:
4279:
4275:
4271:
4264:
4256:
4250:
4242:
4238:
4233:
4228:
4224:
4220:
4216:
4212:
4208:
4204:
4200:
4193:
4185:
4181:
4176:
4171:
4166:
4161:
4157:
4153:
4150:(2): e16103.
4149:
4145:
4144:
4139:
4132:
4124:
4120:
4116:
4112:
4107:
4102:
4098:
4094:
4090:
4086:
4085:
4080:
4073:
4062:
4058:
4054:
4050:
4046:
4042:
4038:
4034:
4030:
4029:
4021:
4014:
4006:
4002:
3998:
3994:
3990:
3986:
3982:
3978:
3974:
3970:
3969:
3961:
3953:
3949:
3944:
3939:
3935:
3931:
3930:
3925:
3918:
3910:
3906:
3901:
3896:
3892:
3888:
3887:
3882:
3875:
3867:
3863:
3859:
3855:
3850:
3845:
3841:
3837:
3833:
3826:
3818:
3814:
3809:
3804:
3800:
3796:
3792:
3788:
3787:
3782:
3775:
3767:
3763:
3758:
3753:
3749:
3745:
3741:
3737:
3736:
3731:
3724:
3716:
3712:
3707:
3702:
3698:
3694:
3690:
3686:
3685:
3680:
3673:
3665:
3661:
3657:
3653:
3649:
3645:
3641:
3637:
3636:
3628:
3626:
3617:
3613:
3608:
3603:
3598:
3593:
3589:
3585:
3581:
3574:
3566:
3562:
3558:
3554:
3547:
3539:
3535:
3530:
3525:
3521:
3517:
3513:
3509:
3505:
3498:
3490:
3484:
3476:
3472:
3467:
3462:
3458:
3454:
3450:
3443:
3435:
3431:
3427:
3423:
3419:
3415:
3411:
3407:
3400:
3392:
3388:
3384:
3380:
3376:
3372:
3369:(8601): 1–4.
3368:
3364:
3357:
3349:
3345:
3341:
3337:
3332:
3327:
3323:
3319:
3315:
3308:
3300:
3296:
3292:
3288:
3285:(6): 608–14.
3284:
3280:
3272:
3264:
3260:
3255:
3250:
3245:
3240:
3236:
3232:
3228:
3221:
3213:
3209:
3204:
3199:
3195:
3191:
3187:
3180:
3165:
3159:
3155:
3154:
3146:
3138:
3134:
3130:
3126:
3121:
3116:
3112:
3108:
3107:
3102:
3095:
3087:
3083:
3078:
3073:
3069:
3065:
3064:
3059:
3052:
3050:
3041:
3037:
3033:
3029:
3025:
3021:
3017:
3013:
3006:
3004:
2995:
2991:
2987:
2983:
2979:
2975:
2971:
2967:
2959:
2951:
2947:
2942:
2937:
2932:
2927:
2923:
2919:
2915:
2908:
2900:
2896:
2891:
2886:
2882:
2878:
2874:
2867:
2859:
2853:
2845:
2839:
2831:
2827:
2822:
2817:
2813:
2809:
2804:
2799:
2795:
2791:
2787:
2783:
2779:
2772:
2764:
2760:
2756:
2752:
2747:
2742:
2738:
2734:
2730:
2723:
2715:
2711:
2707:
2703:
2698:
2693:
2689:
2685:
2681:
2674:
2666:
2662:
2657:
2652:
2648:
2644:
2640:
2636:
2632:
2628:
2624:
2620:
2616:
2609:
2601:
2597:
2592:
2587:
2583:
2579:
2575:
2571:
2567:
2563:
2559:
2552:
2550:
2541:
2537:
2532:
2527:
2522:
2517:
2513:
2509:
2505:
2498:
2496:
2487:
2483:
2478:
2473:
2469:
2465:
2461:
2457:
2453:
2449:
2445:
2438:
2430:
2426:
2421:
2416:
2412:
2408:
2404:
2400:
2396:
2392:
2388:
2381:
2373:
2369:
2366:(3): 519–24.
2365:
2361:
2357:
2350:
2343:
2337:
2335:
2326:
2322:
2318:
2316:9780963117212
2312:
2308:
2307:
2299:
2291:
2285:
2277:
2273:
2268:
2263:
2259:
2255:
2254:
2249:
2242:
2234:
2228:
2220:
2216:
2211:
2206:
2201:
2196:
2192:
2188:
2184:
2177:
2169:
2165:
2160:
2155:
2151:
2147:
2143:
2136:
2128:
2124:
2119:
2114:
2110:
2106:
2102:
2098:
2094:
2090:
2089:
2084:
2077:
2069:
2065:
2060:
2055:
2051:
2047:
2043:
2036:
2028:
2024:
2019:
2014:
2009:
2004:
2000:
1996:
1995:Herpesviridae
1992:
1985:
1977:
1973:
1968:
1963:
1958:
1953:
1949:
1945:
1941:
1934:
1926:
1922:
1917:
1912:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1877:
1868:
1863:
1859:
1855:
1851:
1847:
1843:
1839:
1835:
1828:
1820:
1816:
1811:
1806:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1771:
1763:
1759:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1713:
1705:
1701:
1696:
1691:
1687:
1683:
1678:
1673:
1669:
1665:
1661:
1654:
1646:
1642:
1639:(2): 139–46.
1638:
1634:
1627:
1619:
1615:
1611:
1607:
1603:
1599:
1596:(1): 118–25.
1595:
1591:
1583:
1575:
1571:
1566:
1561:
1557:
1553:
1549:
1545:
1544:
1539:
1532:
1524:
1518:
1514:
1507:
1505:
1503:
1494:
1488:
1484:
1477:
1475:
1473:
1471:
1469:
1453:
1449:
1442:
1427:
1420:
1418:
1417:Herpesviridae
1409:
1405:
1397:
1389:
1387:
1383:
1380:
1376:
1372:
1367:
1363:
1358:
1354:
1353:pyrophosphate
1350:
1346:
1342:
1338:
1329:
1320:
1317:
1315:
1311:
1307:
1303:
1297:
1293:
1289:
1285:
1278:
1275:
1272:
1271:
1270:
1267:
1258:
1256:
1246:
1244:
1239:
1236:
1234:
1230:
1225:
1222:
1221:phase 2 study
1216:
1201:
1199:
1189:
1187:
1177:
1174:
1171:
1167:
1163:
1159:
1154:
1152:
1148:
1144:
1134:
1130:
1128:
1124:
1120:
1116:
1112:
1107:
1103:
1101:
1097:
1092:
1083:
1073:
1070:
1062:
1059:December 2009
1052:
1048:
1044:
1038:
1037:
1033:
1028:This section
1026:
1022:
1017:
1016:
1008:
1006:
1000:
998:
994:
990:
986:
982:
978:
973:
971:
967:
963:
959:
955:
951:
947:
943:
938:
936:
932:
928:
923:
921:
917:
913:
911:
907:
905:
900:
896:
892:
888:
884:
880:
875:
873:
869:
861:
860:H&E stain
857:
853:
849:
845:
841:
837:
835:
831:
827:
823:
819:
815:
811:
806:
804:
800:
796:
792:
789:, and a mild
788:
784:
780:
772:
763:
761:
757:
748:
744:
741:
737:
733:
729:
728:mononucleosis
725:
724:
723:
715:
713:
710:(ideally) or
709:
701:
699:
695:
693:
689:
686:
682:
679:
676:
672:
668:
665:
663:
662:liver failure
659:
658:
657:
654:
652:
647:
645:
635:
632:
629:
624:
622:
618:
614:
610:
609:toxoplasmosis
606:
600:
590:
588:
578:
576:
572:
571:immune system
567:
565:
560:
558:
554:
550:
544:
542:
538:
534:
530:
526:
525:transcription
522:
518:
517:herpesviruses
514:
510:
506:
496:
494:
490:
486:
482:
478:
474:
470:
466:
462:
447:
445:
441:
437:
433:
424:
422:
419:and eventual
418:
414:
410:
406:
402:
401:birth defects
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
353:
351:
347:
343:
342:breast cancer
339:
335:
331:
327:
323:
319:
315:
311:
306:
304:
300:
296:
292:
291:
286:
285:
284:Herpesviridae
280:
276:
275:
274:Herpesviridae
270:
269:
265:in the genus
264:
260:
256:
252:
248:
247:
236:
233:
232:
230:
227:
223:
219:
218:
213:
210:
209:
206:
205:
201:
198:
197:
194:
193:
189:
186:
185:
182:
181:
180:Herpesvirales
177:
174:
173:
170:
169:
165:
162:
161:
158:
157:
156:Peploviricota
153:
150:
149:
146:
145:
141:
138:
137:
134:
133:
132:Duplodnaviria
129:
126:
123:
122:
119:
116:
113:
112:
107:
102:
98:
95:
90:
86:
81:
78:
74:
67:
64:
60:
57:
54:
52:
48:
43:
37:
33:
32:Burao Airport
19:
7932:
7863:
7834:Tuberculosis
7767:During birth
7627:
7620:
7596:
7589:Pancreatitis
7571:
7559:
7547:
7535:
7528:
7509:
7484:
7477:
7470:
7458:
7437:
7400:
7386:
7347:
7340:
7326:
7320:
7287:
7281:
7261:
7247:
7233:
7204:
7180:
7162:
7117:Pericarditis
7109:
7078:
7064:
7037:
7018:
6976:
6961:
6942:
6928:
6907:
6890:Encephalitis
6859:
6832:
6813:
6792:
6758:
6744:
6705:
6691:
6531:Rhadinovirus
6529:
6511:
6466:
6443:Manticavirus
6441:
6381:
6321:
6303:
6269:
6222:Roseolovirus
6220:
6190:
6160:
6130:
6085:
6060:
6049:
5935:
5847:Simplexvirus
5845:
5820:
5775:
5750:
5728:
5706:
5670:Salmonivirus
5668:
5638:
5605:Cyprinivirus
5603:
5573:
5558:
5532:
5514:
5499:
5491:
5485:
5479:
5473:
5467:
5455:
5405:
5390:
5375:
5351:
5345:
5300:
5275:the original
5246:
5240:
5227:
5202:
5198:
5192:
5159:
5155:
5149:
5114:
5110:
5100:
5067:
5063:
5057:
5012:
5008:
4998:
4971:
4967:
4957:
4916:
4912:
4906:
4869:
4863:
4853:
4841:. Retrieved
4829:
4817:
4805:. Retrieved
4793:
4781:
4746:
4742:
4732:
4697:
4693:
4683:
4664:
4652:. Retrieved
4648:the original
4643:
4634:
4622:. Retrieved
4618:the original
4613:
4604:
4592:. Retrieved
4588:the original
4581:
4572:
4560:. Retrieved
4550:
4538:. Retrieved
4528:
4516:. Retrieved
4506:
4494:. Retrieved
4484:
4449:
4445:
4435:
4400:
4396:
4386:
4374:. Retrieved
4352:
4348:
4338:
4326:. Retrieved
4322:the original
4312:
4277:
4273:
4263:
4249:
4206:
4202:
4192:
4147:
4141:
4131:
4088:
4082:
4072:
4061:the original
4032:
4026:
4013:
3975:(1): 56–65.
3972:
3966:
3960:
3933:
3927:
3917:
3890:
3884:
3874:
3839:
3835:
3825:
3790:
3786:Nature Aging
3784:
3774:
3739:
3733:
3723:
3688:
3682:
3672:
3639:
3633:
3587:
3583:
3573:
3559:(2): 86–93.
3556:
3552:
3546:
3514:(8): 612–4.
3511:
3507:
3497:
3483:
3459:(4): 191–7.
3456:
3452:
3442:
3409:
3405:
3399:
3366:
3362:
3356:
3321:
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2257:
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2186:
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1451:
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1392:Epidemiology
1334:
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1140:
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1041:Please help
1029:
1001:
974:
950:inflammaging
939:
924:
920:cytoskeleton
914:
902:
885:infants and
876:
865:
807:
803:asymptomatic
776:
766:Pathogenesis
752:
740:splenomegaly
721:
705:
655:
648:
641:
633:
625:
602:
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568:
561:
545:
531:and further
509:cell culture
502:
458:
455:Transmission
431:
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350:glioblastoma
307:
288:
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278:
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203:
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179:
167:
155:
143:
131:
124:
114:(unranked):
76:
65:
36:
7888:Wikispecies
7805:Listeriosis
7789:Listeriosis
7779:Candidiasis
7711:Hepatitis B
7686:Gestational
7486:Coronavirus
7227:Common cold
7139:acute viral
7122:Myocarditis
6966:(probable)
6718:Anal cancer
6627:Wikispecies
6513:Patagivirus
5534:Ostreavirus
5295:‹ The
4376:3 September
3584:PLOS Pathog
1730:: 167–183.
1366:exonuclease
1341:Ganciclovir
1284:Ganciclovir
1209:Vaccination
1119:hepatitis A
1005:vaccination
927:endothelium
848:placentitis
830:breast milk
795:lymphocytes
781:similar to
712:ganciclovir
698:esophagitis
692:pneumonitis
685:large bowel
513:fibroblasts
505:endothelial
499:Replication
489:breast milk
440:pharyngitis
361:third world
357:first world
301:. CMV is a
297:from other
7992:Categories
7613:Urogenital
7479:Astrovirus
7439:Adenovirus
7263:SARS-CoV-2
7020:Poliovirus
6895:meningitis
6614:Unassigned
6468:Percavirus
6305:Bossavirus
5822:Scutavirus
5777:Mardivirus
4872:(1): 207.
4654:16 October
4624:16 October
4594:16 October
4562:23 January
4540:23 January
4518:22 October
4496:26 October
3406:The Lancet
3363:The Lancet
2924:(8): 405.
1446:taxonomy.
1400:References
1375:sequencing
1357:letermovir
1306:Letermovir
1204:Prevention
1100:viral load
1091:antibodies
844:Micrograph
444:adenopathy
373:antibodies
316:, such as
94:pneumocyte
7948:Q24808725
7784:Gonorrhea
7732:Bacteria
7524:RNA virus
7505:DNA virus
7497:Hepatitis
7472:Norovirus
7460:Rotavirus
7454:RNA virus
7433:DNA virus
7379:Esophagus
7307:Influenza
7193:RNA virus
7155:DNA virus
6924:RNA virus
6903:DNA virus
6809:RNA virus
6687:DNA virus
6679:Oncovirus
6383:Macavirus
6192:Quwivirus
5752:Iltovirus
5516:Aurivirus
4223:1871-5265
3340:1058-4838
3212:249441439
3196:: 35–45.
2986:0022-3476
2812:0027-8424
2755:0042-6822
2706:0022-1554
2647:0036-8075
2582:0022-538X
2514:(3): 70.
2468:0022-1007
2411:0022-538X
2109:0022-538X
1907:1476-5594
1858:1476-5500
1801:1476-5594
1744:2352-3964
1686:2072-6694
1349:Foscarnet
1345:Cidofovir
1339:, pUL54.
1296:cidofovir
1292:Foscarnet
1261:Treatment
1227:In 2013,
1030:does not
1011:Diagnosis
883:postnatal
879:pre-natal
791:hepatitis
553:integrins
421:mortality
417:morbidity
389:infection
281:. Within
211:Species:
139:Kingdom:
51:Specialty
7942:Wikidata
7921:11460003
7908:46699982
7873:Wikidata
7692:Viruses
7622:BK virus
7425:diarrhea
7269:COVID-19
7011:Myelitis
6206:MschBHV1
5354:. 10359.
5334:Archived
5297:template
5263:22541724
5219:19853628
5184:46533224
5176:10968428
5141:15728878
5092:23668301
5084:11428978
4898:34663377
4834:Archived
4798:Archived
4773:10194460
4724:27495775
4672:Archived
4476:19297572
4427:21236396
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4304:12364375
4241:21827433
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4143:PLOS One
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3263:18371229
3129:25684400
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2994:25466679
2950:30081449
2899:21364849
2830:14623981
2733:Virology
2665:23180859
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2508:Vaccines
2486:10432281
2429:10906217
2372:12588074
2325:21413307
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2068:17029132
2027:21473750
2001:(6): 6.
1976:24062739
1925:37147437
1916:10256614
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1867:11257955
1819:37634008
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1781:Oncogene
1762:29628341
1704:37894361
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1618:41446671
1610:22101257
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1431:13 March
1382:Archived
1312:and the
1173:antibody
970:COVID-19
895:leukemia
856:globules
799:immunity
779:syndrome
487:and via
450:Virology
405:deafness
226:Synonyms
187:Family:
151:Phylum:
7375:Pharynx
6879:Central
6492:MusHV-1
6452:PhaHV-1
6337:CeHV-14
6332:CalHV-3
5811:SpAHV-1
5679:SalHV-1
5649:AciHV-2
5614:AngHV-1
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5299:below (
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5017:Bibcode
4990:1706982
4949:4309307
4941:1319560
4921:Bibcode
4889:8524946
4843:27 June
4807:27 June
4715:5030152
4467:2753425
4418:3340426
4232:3730495
4175:3040745
4152:Bibcode
4106:2950794
4028:Vaccine
3977:Bibcode
3808:8570568
3757:5573867
3706:5514425
3607:2673691
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3169:26 June
3137:5969716
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3032:6681168
2941:6116058
2918:Viruses
2890:3046747
2790:Bibcode
2763:9426445
2714:9889260
2656:3817102
2627:Bibcode
2619:Science
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1967:3772506
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1753:5952350
1664:Cancers
1565:7462738
1457:25 July
1249:Hygiene
1051:removed
1036:sources
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852:nucleus
846:of CMV
760:cancers
651:colitis
613:rubella
575:latency
564:nucleus
387:. HCMV
299:mammals
199:Genus:
175:Order:
163:Class:
7742:Other
7039:HTLV-I
6984:Rabies
6834:HTLV-I
6595:SaHV-2
6585:MuHV-4
6565:McHV-5
6555:CrHV-2
6550:BoHV-4
6540:AtHV-2
6521:VeHV-3
6502:VeHV-1
6497:PhHV-3
6487:FeHV-1
6457:VoHV-1
6422:SuHV-3
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6342:GoHV-1
6313:DeHV-1
6292:SgHV-1
6286:PhHV-2
6256:SuHV-2
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6246:McHV-9
6231:HHV-6A
6211:TuHV-1
6201:CaHV-2
6171:ElHV-1
6141:MuHV-1
6121:SaHV-4
6111:PaHV-3
6106:PnHV-2
6101:MnHV-1
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6076:CbHV-1
6071:AoHV-1
6036:SuHV-1
6031:PhHV-1
6026:MoHV-1
6016:FeHV-1
5976:CvHV-1
5971:CeHV-9
5966:CpHV-1
5961:CaHV-1
5956:BuHV-1
5946:BoHV-1
5926:SaHV-1
5921:PtHV-1
5916:PaHV-2
5911:PnHV-3
5901:MaHV-1
5886:McHV-1
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5866:CeHV-2
5861:BoHV-2
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5836:TeHV-3
5831:ChHV-5
5806:MeHV-1
5796:GaHV-2
5791:CoHV-1
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5766:PsHV-1
5761:GaHV-1
5739:ChHV-6
5717:IgHV-2
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411:, and
365:innate
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7635:Mumps
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1143:ELISA
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870:. On
826:semen
822:tears
818:blood
810:urine
787:fever
481:urine
473:tears
469:blood
465:urine
436:fever
381:virus
263:virus
259:HHV-5
125:Realm
118:Virus
7970:NCBI
7349:hMPV
7221:OC43
7217:HKU1
7213:NL63
7209:229E
6867:AIDS
6746:KSHV
6618:ICTV
5407:MeSH
5396:9-CM
5259:PMID
5215:PMID
5172:PMID
5137:PMID
5080:PMID
5045:PMID
4986:PMID
4937:PMID
4894:PMID
4845:2018
4809:2018
4769:PMID
4720:PMID
4656:2017
4626:2017
4596:2017
4564:2016
4542:2016
4520:2015
4498:2015
4472:PMID
4423:PMID
4378:2020
4367:PMID
4330:2007
4300:PMID
4237:PMID
4219:ISSN
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1459:2020
1433:2019
1371:EC50
1253:The
1034:any
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993:MICB
991:and
977:UL16
904:AIDS
758:and
738:and
726:CMV
696:CMV
690:CMV
615:and
549:CD18
367:and
348:and
255:HCMV
7957:CoL
7903:EoL
7839:HIV
7819:By
7721:HIV
7629:MuV
7598:CBV
7573:HEV
7561:HDV
7549:HCV
7537:HAV
7530:CBV
7511:HBV
7388:MuV
7319:V,
7111:CBV
7080:HSV
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6944:LCV
6930:MeV
6861:HIV
6815:HCV
6760:EBV
6707:HPV
6693:HBV
6620:––
5392:ICD
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5377:ICD
5323:US
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