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HDAC4

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Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR".
364: 263: 3445:"Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor" 3763: 1470:/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly but through 3584:"Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5" 3722: 1481:. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation. 3756: 2085:"Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation" 1130: 186: 1111: 3531:"Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras" 2334:"Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras" 1602: 3749: 2902:
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction".
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Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F (July 2007).
1695: 3707: 1677: 3019:"Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins" 49: 3655: 2035:"HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression" 1362: 1369: 2642:
Franco PJ, Li G, Wei LN (August 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase".
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Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (November 2004).
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researchers also concluded that it promotes healthy vision: Reduced levels of the protein led to the death of the rod
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structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the
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Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997).
350: 2595:"Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway" 3263:"Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization" 2231:"Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization" 1664: 1643: 1578: 1572: 327: 3967: 1175: 4230: 2539: 1156: 249: 224: 166: 1510: 3183:
Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (November 1999).
2777:"HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF" 2687:"The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases" 2391:
Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (November 1999).
363: 262: 4345: 3929: 1986:"Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3" 1451: 3400:
Wang AH, Kruhlak MJ, Wu J, Bertos NR, Vezmar M, Posner BI, Bazett-Jones DP, Yang XJ (September 2000).
356: 255: 4331: 4318: 4305: 4292: 4279: 4266: 4253: 4215: 3680: 153: 3228:"Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4" 4225: 4179: 4122: 3776: 3741: 3646: 2863:
Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators".
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Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, Naoe T, Saito H (December 2003).
4148: 4067: 2540:"mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity" 1584: 3359:"Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3" 3185:"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor" 2393:"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor" 4220: 3977: 3673: 3595: 3542: 3491: 3480:"Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation" 3274: 3100: 2345: 2242: 1729: 1471: 238: 194: 2201: 8: 4184: 3957: 3856: 3052:
Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999).
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Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999).
1616: 1467: 3599: 3546: 3495: 3278: 3104: 2349: 2246: 1945:"Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor" 1943:
Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002).
1832:"Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation" 1733: 4117: 3982: 3512: 3479: 3166: 3141: 3005: 2851: 2667: 2572: 2515: 2490: 2065: 2015: 1917: 1892: 1494: 1490: 198: 3383: 3358: 3340: 3315: 3054:"A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p" 3017:
Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N (February 1997).
2957: 2932: 2876: 2838: 2821: 2655: 2619: 2594: 2192: 2109: 2084: 1777:"A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p" 1045: 1040: 1035: 1030: 1025: 1020: 1015: 1010: 1005: 1000: 995: 990: 985: 980: 975: 970: 965: 960: 955: 950: 945: 940: 935: 930: 925: 920: 915: 910: 905: 900: 895: 890: 885: 880: 875: 870: 865: 860: 855: 850: 845: 840: 835: 830: 825: 820: 804: 799: 794: 789: 784: 779: 774: 769: 764: 759: 754: 749: 733: 728: 723: 718: 713: 708: 703: 698: 693: 688: 683: 678: 673: 668: 663: 658: 653: 648: 643: 4380: 3952: 3623: 3618: 3583: 3570: 3565: 3530: 3517: 3466: 3431: 3426: 3417: 3401: 3388: 3345: 3302: 3297: 3262: 3249: 3214: 3209: 3184: 3171: 3140:
Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (September 1999).
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Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (September 1999).
2471: 2466: 2457: 2441: 2422: 2417: 2392: 2373: 2368: 2333: 2311: 2270: 2265: 2230: 2206: 2155: 2114: 2100: 2057: 2007: 1966: 1922: 1853: 1798: 1757: 1752: 1717: 146: 42: 3089:"Three proteins define a class of human histone deacetylases related to yeast Hda1p" 3009: 2855: 2671: 2576: 2288:
Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001).
1718:"Three proteins define a class of human histone deacetylases related to yeast Hda1p" 178: 4163: 4158: 4132: 4060: 3613: 3603: 3560: 3550: 3507: 3499: 3456: 3421: 3413: 3378: 3370: 3335: 3327: 3292: 3282: 3239: 3204: 3196: 3161: 3153: 3118: 3108: 3065: 3030: 2987: 2952: 2944: 2911: 2880: 2872: 2833: 2788: 2747: 2739: 2698: 2651: 2614: 2606: 2554: 2510: 2502: 2461: 2453: 2412: 2404: 2363: 2353: 2301: 2260: 2250: 2196: 2188: 2145: 2104: 2096: 2069: 2049: 2019: 1997: 1956: 1912: 1904: 1843: 1788: 1747: 1737: 443: 374: 318: 273: 3731:: The 97H/F mutant Structure of a glutamine-rich domain from histone deacetylase 4 4210: 4194: 4107: 2593:
Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000).
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
157:, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID 4359: 4248: 4189: 4009: 3972: 3944: 3896: 3891: 3878: 3828: 3790: 3588:
Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
3157: 3142:"HDAC4 deacetylase associates with and represses the MEF2 transcription factor" 3093:
Proceedings of the National Academy of Sciences of the United States of America
2506: 2491:"HDAC4 deacetylase associates with and represses the MEF2 transcription factor" 2338:
Proceedings of the National Academy of Sciences of the United States of America
2235:
Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T (August 2001).
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Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000).
4369: 4153: 4112: 4036: 3962: 3911: 3659: 3070: 3053: 2743: 2442:"Histone deacetylase 4 possesses intrinsic nuclear import and export signals" 1793: 1776: 630: 3035: 3018: 1908: 601: 579: 457: 4102: 3818: 3798: 3627: 3608: 3574: 3555: 3529:
Zhou X, Richon VM, Wang AH, Yang XJ, Rifkind RA, Marks PA (December 2000).
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Zhou X, Richon VM, Wang AH, Yang XJ, Rifkind RA, Marks PA (December 2000).
2315: 2306: 2290:"Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo" 2289: 2274: 2255: 2210: 2159: 2150: 2133: 2118: 2061: 2011: 1970: 1961: 1944: 1926: 1857: 1802: 1761: 1742: 436: 215: 3044: 3001: 2966: 2923: 2847: 2134:"Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation" 2002: 1985: 1409: 1404: 4326: 4261: 4097: 3886: 3813: 3803: 1530: 1459: 1220: 1201: 2728:"Differential localization of HDAC4 orchestrates muscle differentiation" 2610: 4041: 3924: 3841: 2948: 2774: 1463: 1455: 335: 232: 182: 2885: 2053: 1489:
Studies have shown that HDAC4 regulates bone and muscle development.
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RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000).
2975: 4354: 3919: 3402:"Regulation of histone deacetylase 4 by binding of 14-3-3 proteins" 1942: 1393: 1031:
negative regulation of pri-miRNA transcription by RNA polymerase II
961:
response to denervation involved in regulation of muscle adaptation
821:
positive regulation of reactive oxygen species biosynthetic process
2822:"What's up and down with histone deacetylation and transcription?" 1893:"HDAC4 regulates neuronal survival in normal and diseased retinas" 3861: 3716:: Structure of a glutamine-rich domain from histone deacetylase 4 2032: 1447: 1429: 1187: 1142: 1060: 1056: 846:
regulation of cardiac muscle contraction by calcium ion signaling
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negative regulation of DNA-binding transcription factor activity
876:
positive regulation of DNA-binding transcription factor activity
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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NAD-dependent histone deacetylase activity (H3-K14 specific)
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Micheli L, D'Andrea G, Leonardi L, Tirone F (July 2017).
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positive regulation of transcription by RNA polymerase II
881:
negative regulation of transcription by RNA polymerase II
3316:"BCoR, a novel corepressor involved in BCL-6 repression" 3314:
Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000).
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McKinsey TA, Zhang CL, Lu J, Olson EN (November 2000).
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Zhang CL, McKinsey TA, Lu JR, Olson EN (January 2001).
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Glenisson W, Castronovo V, Waltregny D (October 2007).
1021:
positive regulation of smooth muscle cell proliferation
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Franco PJ, Farooqui M, Seto E, Wei LN (August 2001).
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Grozinger CM, Hassig CA, Schreiber SL (April 1999).
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Grozinger CM, Hassig CA, Schreiber SL (April 1999).
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negative regulation of cell population proliferation
951:
positive regulation of cell population proliferation
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negative regulation of transcription, DNA-templated
921:
positive regulation of smooth muscle cell migration
916:
positive regulation of transcription, DNA-templated
546:
dentate gyrus of hippocampal formation granule cell
3581: 3528: 3260: 2331: 2228: 2082: 1656: 1654: 1652: 1635: 1633: 1631: 911:regulation of striated muscle cell differentiation 3582:McKinsey TA, Zhang CL, Olson EN (December 2000). 981:cellular response to parathyroid hormone stimulus 896:negative regulation of osteoblast differentiation 373: 272: 4367: 3225: 2083:Zhang CL, McKinsey TA, Olson EN (October 2002). 1603:Zinc finger and BTB domain-containing protein 16 946:cardiac muscle hypertrophy in response to stress 3356: 2588: 2586: 2327: 2325: 2224: 2222: 2220: 2173: 2171: 2169: 1938: 1936: 1649: 1628: 1458:progression, and developmental events. Histone 966:regulation of skeletal muscle fiber development 941:positive regulation of neuron apoptotic process 1711: 1709: 1661:GRCm38: Ensembl release 89: ENSMUSG00000026313 956:negative regulation of myotube differentiation 4068: 3757: 3681: 2819: 991:positive regulation of lamellipodium assembly 2976:"Transcriptional control. Sinful repression" 2768: 2719: 2678: 2635: 2583: 2531: 2482: 2433: 2384: 2322: 2281: 2217: 2166: 2125: 2076: 1977: 1933: 1884: 3226:Youn HD, Grozinger CM, Liu JO (July 2000). 2933:"Large-scale concatenation cDNA sequencing" 2641: 1768: 1706: 1640:GRCh38: Ensembl release 89: ENSG00000068024 1046:positive regulation of male mating behavior 4075: 4061: 3764: 3750: 3688: 3674: 3656:United States National Library of Medicine 1817:"Entrez Gene: HDAC4 histone deacetylase 4" 886:positive regulation of protein sumoylation 871:cellular response to tumor necrosis factor 861:regulation of transcription, DNA-templated 3645:at the U.S. National Library of Medicine 3617: 3607: 3564: 3554: 3511: 3460: 3425: 3382: 3339: 3296: 3286: 3243: 3208: 3165: 3122: 3112: 3069: 3034: 2991: 2956: 2884: 2837: 2792: 2751: 2702: 2618: 2558: 2514: 2465: 2416: 2367: 2357: 2305: 2264: 2254: 2200: 2149: 2108: 2001: 1960: 1916: 1890: 1847: 1792: 1751: 1741: 866:regulation of gene expression, epigenetic 851:negative regulation of glycolytic process 3654:This article incorporates text from the 3261:Grozinger CM, Schreiber SL (July 2000). 2439: 2229:Grozinger CM, Schreiber SL (July 2000). 1484: 936:cellular response to mechanical stimulus 500:Skeletal muscle tissue of biceps brachii 4368: 2973: 4056: 3993:Activation-induced cytidine deaminase 3745: 3669: 1809: 378: 339: 334: 277: 236: 231: 2644:Molecular and Cellular Endocrinology 3449:The Journal of Biological Chemistry 3232:The Journal of Biological Chemistry 3058:The Journal of Biological Chemistry 2547:The Journal of Biological Chemistry 2440:Wang AH, Yang XJ (September 2001). 2294:The Journal of Biological Chemistry 1949:The Journal of Biological Chemistry 1781:The Journal of Biological Chemistry 1567:Myocyte-specific enhancer factor 2A 724:promoter-specific chromatin binding 13: 2820:Pazin MJ, Kadonaga JT (May 1997). 2812: 659:transcription corepressor activity 14: 4392: 3636: 1891:Chen B, Cepko CL (January 2009). 1432:that in humans is encoded by the 4353: 3721: 3706: 3418:10.1128/MCB.20.18.6904-6912.2000 2458:10.1128/mcb.21.17.5992-6005.2001 2101:10.1128/mcb.22.20.7302-7312.2002 600: 362: 355: 349: 326: 261: 254: 248: 223: 24: 3775:: carbon-nitrogen non-peptide ( 3695: 2026: 1579:Nuclear receptor co-repressor 2 1573:Nuclear receptor co-repressor 1 1504: 765:transcription repressor complex 3968:Inosine monophosphate synthase 3406:Molecular and Cellular Biology 3189:Molecular and Cellular Biology 2446:Molecular and Cellular Biology 2397:Molecular and Cellular Biology 2202:11858/00-001M-0000-002C-9FF9-9 2089:Molecular and Cellular Biology 2042:Journal of Cellular Physiology 1864: 1823: 1688: 1670: 611:More reference expression data 580:More reference expression data 1: 2877:10.1016/S0168-9525(03)00073-8 2839:10.1016/S0092-8674(00)80211-1 2656:10.1016/s0303-7207(03)00254-5 2193:10.1016/s1097-2765(01)00429-4 1622: 996:regulation of protein binding 841:peptidyl-lysine deacetylation 649:sequence-specific DNA binding 488:muscle layer of sigmoid colon 347: 246: 1849:10.1016/j.bbamcr.2007.05.016 901:transcription, DNA-templated 714:protein deacetylase activity 674:transcription factor binding 664:histone deacetylase activity 7: 4376:Genes on human chromosome 2 4082: 1610: 1442: 831:skeletal system development 755:histone deacetylase complex 679:histone deacetylase binding 10: 4397: 3930:Protein-arginine deiminase 3852:Fatty acid amide hydrolase 1452:transcriptional regulation 906:nervous system development 805:protein-containing complex 4239: 4231:Michaelis–Menten kinetics 4203: 4172: 4141: 4090: 4026: 4003: 3938: 3905: 3872: 3784: 3701: 1696:"Mouse PubMed Reference:" 1678:"Human PubMed Reference:" 1497:and bipolar cells in the 1408: 1403: 1399: 1392: 1376: 1357: 1342: 1338: 1305: 1301: 1294: 1279: 1275: 1242: 1238: 1231: 1218: 1214: 1199: 1195: 1186: 1173: 1169: 1154: 1150: 1141: 1128: 1124: 1109: 1105: 1096: 1081: 1074: 1070: 1054: 856:response to interleukin-1 734:SUMO transferase activity 719:identical protein binding 629: 625: 608: 599: 590: 577: 526: 517: 464: 455: 425: 417: 413: 396: 383: 346: 325: 316: 312: 295: 282: 245: 222: 213: 209: 164: 161: 151: 144: 139: 68: 63: 46: 41: 36: 32: 23: 18: 4123:Diffusion-limited enzyme 3647:Medical Subject Headings 3375:10.1093/emboj/19.16.4342 3158:10.1093/emboj/18.18.5099 3071:10.1074/jbc.274.17.11713 2507:10.1093/emboj/18.18.5099 1794:10.1074/jbc.274.17.11713 1509:HDAC4 has been shown to 1450:play a critical role in 1363:Chr 2: 239.05 – 239.4 Mb 931:histone H4 deacetylation 826:histone H3 deacetylation 542:Rostral migratory stream 480:tibialis anterior muscle 3847:Aspartylglucosaminidase 3320:Genes & Development 2904:Analytical Biochemistry 2691:Molecular Endocrinology 2599:Genes & Development 1909:10.1126/science.1166226 1881:, 3 (March 2009), p. 23 1370:Chr 1: 91.86 – 92.12 Mb 558:interventricular septum 3609:10.1073/pnas.260501497 3556:10.1073/pnas.250494697 3462:10.1074/jbc.M007364200 3332:10.1101/gad.14.14.1810 3288:10.1073/pnas.140199597 3245:10.1074/jbc.C000304200 3201:10.1128/mcb.19.11.7816 3114:10.1073/pnas.96.9.4868 2974:Wolffe AP (May 1997). 2916:10.1006/abio.1996.0138 2794:10.1038/sj.onc.1208128 2744:10.1093/nar/29.16.3439 2732:Nucleic Acids Research 2704:10.1210/mend.15.8.0682 2560:10.1074/jbc.M908437199 2409:10.1128/mcb.19.11.7816 2359:10.1073/pnas.250494697 2307:10.1074/jbc.M104935200 2256:10.1073/pnas.140199597 2151:10.1038/sj.onc.1206902 1962:10.1074/jbc.M201736200 1743:10.1073/pnas.96.9.4868 1462:/deacetylation alters 1026:chromatin organization 976:B cell differentiation 971:osteoblast development 760:neuromuscular junction 704:protein kinase binding 566:skeletal muscle tissue 4216:Eadie–Hofstee diagram 4149:Allosteric regulation 3036:10.1093/dnares/4.1.53 2003:10.1096/fj.06-7548com 1585:Testicular receptor 2 1485:Clinical significance 1472:transcription factors 1422:Histone deacetylase 4 1036:protein deacetylation 1006:histone deacetylation 986:inflammatory response 684:potassium ion binding 4226:Lineweaver–Burk plot 3978:GTP cyclohydrolase I 3643:HDAC4+protein,+human 836:chromatin remodeling 476:gastrocnemius muscle 341:Chromosome 1 (mouse) 239:Chromosome 2 (human) 64:List of PDB id codes 37:Available structures 3958:Adenosine deaminase 3857:Histone deacetylase 3600:2000PNAS...9714400M 3547:2000PNAS...9714329Z 3496:2000Natur.408..106M 3279:2000PNAS...97.7835G 3105:1999PNAS...96.4868G 2611:10.1101/gad.14.1.45 2350:2000PNAS...9714329Z 2247:2000PNAS...97.7835G 1875:Scientific American 1734:1999PNAS...96.4868G 1617:Histone deacetylase 1468:histone deacetylase 1041:protein sumoylation 4185:Enzyme superfamily 4118:Enzyme promiscuity 3983:Cytidine deaminase 3942:: Cyclic amidines/ 3909:: Linear amidines/ 3658:, which is in the 2949:10.1101/gr.7.4.353 2865:Trends in Genetics 1491:Harvard University 1176:ENSMUSG00000026313 814:Biological process 743:Cellular component 709:hydrolase activity 637:Molecular function 4341: 4340: 4050: 4049: 3953:Guanine deaminase 3788:: Linear amides / 3739: 3738: 2452:(17): 5992–6005. 2054:10.1002/jcp.25467 1871:Protein for Sight 1419: 1418: 1415: 1414: 1388: 1387: 1353: 1352: 1332: 1331: 1290: 1289: 1269: 1268: 1227: 1226: 1208: 1207: 1182: 1181: 1163: 1162: 1137: 1136: 1118: 1117: 1066: 1065: 926:B cell activation 694:metal ion binding 689:chromatin binding 621: 620: 617: 616: 586: 585: 573: 572: 511: 510: 409: 408: 308: 307: 203:HDAC4 - orthologs 135: 134: 131: 130: 47:Ortholog search: 4388: 4358: 4357: 4349: 4221:Hanes–Woolf plot 4164:Enzyme activator 4159:Enzyme inhibitor 4133:Enzyme catalysis 4077: 4070: 4063: 4054: 4053: 3876:: Cyclic amides/ 3766: 3759: 3752: 3743: 3742: 3725: 3710: 3690: 3683: 3676: 3667: 3666: 3631: 3621: 3611: 3578: 3568: 3558: 3541:(26): 14329–33. 3525: 3515: 3504:10.1038/35040593 3490:(6808): 106–11. 3474: 3464: 3439: 3429: 3396: 3386: 3363:The EMBO Journal 3353: 3343: 3310: 3300: 3290: 3257: 3247: 3222: 3212: 3179: 3169: 3152:(18): 5099–107. 3146:The EMBO Journal 3136: 3126: 3116: 3083: 3073: 3064:(17): 11713–20. 3048: 3038: 3013: 2995: 2993:10.1038/387016a0 2970: 2960: 2927: 2898: 2888: 2859: 2841: 2807: 2806: 2796: 2772: 2766: 2765: 2755: 2723: 2717: 2716: 2706: 2682: 2676: 2675: 2639: 2633: 2632: 2622: 2590: 2581: 2580: 2562: 2544: 2535: 2529: 2528: 2518: 2501:(18): 5099–107. 2495:The EMBO Journal 2486: 2480: 2479: 2469: 2437: 2431: 2430: 2420: 2388: 2382: 2381: 2371: 2361: 2344:(26): 14329–33. 2329: 2320: 2319: 2309: 2300:(38): 35826–35. 2285: 2279: 2278: 2268: 2258: 2226: 2215: 2214: 2204: 2175: 2164: 2163: 2153: 2129: 2123: 2122: 2112: 2080: 2074: 2073: 2048:(7): 1696–1707. 2039: 2030: 2024: 2023: 2005: 1981: 1975: 1974: 1964: 1955:(24): 22045–52. 1940: 1931: 1930: 1920: 1888: 1882: 1868: 1862: 1861: 1851: 1827: 1821: 1820: 1813: 1807: 1806: 1796: 1787:(17): 11713–20. 1772: 1766: 1765: 1755: 1745: 1713: 1704: 1703: 1692: 1686: 1685: 1674: 1668: 1658: 1647: 1637: 1424:, also known as 1401: 1400: 1372: 1365: 1348: 1336: 1335: 1327: 1299: 1298: 1295:RefSeq (protein) 1285: 1273: 1272: 1264: 1236: 1235: 1212: 1211: 1193: 1192: 1167: 1166: 1148: 1147: 1122: 1121: 1103: 1102: 1072: 1071: 669:zinc ion binding 627: 626: 613: 604: 597: 596: 582: 522: 520:Top expressed in 515: 514: 492:endothelial cell 460: 458:Top expressed in 453: 452: 432: 431: 415: 414: 405: 392: 381: 366: 359: 353: 342: 330: 314: 313: 304: 291: 280: 265: 258: 252: 241: 227: 211: 210: 205: 156: 149: 126: 61: 60: 55: 34: 33: 28: 16: 15: 4396: 4395: 4391: 4390: 4389: 4387: 4386: 4385: 4366: 4365: 4364: 4352: 4344: 4342: 4337: 4249:Oxidoreductases 4235: 4211:Enzyme kinetics 4199: 4195:List of enzymes 4168: 4137: 4108:Catalytic triad 4086: 4081: 4051: 4046: 4022: 4010:Aminohydrolases 4008: 3999: 3945:Aminohydrolases 3943: 3934: 3910: 3901: 3879:Amidohydrolases 3877: 3868: 3791:Amidohydrolases 3789: 3780: 3770: 3740: 3735: 3732: 3726: 3717: 3711: 3697: 3694: 3639: 3634: 3594:(26): 14400–5. 3412:(18): 6904–12. 3369:(16): 4342–50. 3326:(14): 1810–23. 3273:(14): 7835–40. 3238:(29): 22563–7. 3195:(11): 7816–27. 2937:Genome Research 2815: 2813:Further reading 2810: 2787:(54): 8777–84. 2773: 2769: 2738:(16): 3439–47. 2724: 2720: 2683: 2679: 2640: 2636: 2591: 2584: 2553:(20): 15594–9. 2542: 2536: 2532: 2487: 2483: 2438: 2434: 2403:(11): 7816–27. 2389: 2385: 2330: 2323: 2286: 2282: 2241:(14): 7835–40. 2227: 2218: 2176: 2167: 2144:(57): 9176–84. 2130: 2126: 2095:(20): 7302–12. 2081: 2077: 2037: 2031: 2027: 1982: 1978: 1941: 1934: 1903:(5911): 256–9. 1889: 1885: 1869: 1865: 1842:(10): 1572–82. 1828: 1824: 1815: 1814: 1810: 1773: 1769: 1714: 1707: 1694: 1693: 1689: 1676: 1675: 1671: 1659: 1650: 1638: 1629: 1625: 1613: 1608: 1507: 1487: 1445: 1410:View/Edit Mouse 1405:View/Edit Human 1368: 1361: 1358:Location (UCSC) 1344: 1323: 1319: 1315: 1311: 1307: 1281: 1260: 1256: 1252: 1248: 1244: 1157:ENSG00000068024 1050: 809: 738: 699:protein binding 609: 578: 569: 564: 560: 556: 552: 550:muscle of thigh 548: 544: 540: 536: 532: 518: 507: 502: 498: 494: 490: 486: 484:muscle of thigh 482: 478: 474: 470: 456: 400: 387: 379: 369: 368: 367: 360: 340: 317:Gene location ( 299: 286: 278: 268: 267: 266: 259: 237: 214:Gene location ( 165: 152: 145: 70: 48: 12: 11: 5: 4394: 4384: 4383: 4378: 4363: 4362: 4339: 4338: 4336: 4335: 4322: 4309: 4296: 4283: 4270: 4257: 4243: 4241: 4237: 4236: 4234: 4233: 4228: 4223: 4218: 4213: 4207: 4205: 4201: 4200: 4198: 4197: 4192: 4187: 4182: 4176: 4174: 4173:Classification 4170: 4169: 4167: 4166: 4161: 4156: 4151: 4145: 4143: 4139: 4138: 4136: 4135: 4130: 4125: 4120: 4115: 4110: 4105: 4100: 4094: 4092: 4088: 4087: 4080: 4079: 4072: 4065: 4057: 4048: 4047: 4045: 4044: 4039: 4033: 4031: 4024: 4023: 4021: 4020: 4014: 4012: 4001: 4000: 3998: 3997: 3996: 3995: 3990: 3980: 3975: 3973:DCMP deaminase 3970: 3965: 3960: 3955: 3949: 3947: 3936: 3935: 3933: 3932: 3927: 3922: 3916: 3914: 3912:Ureohydrolases 3903: 3902: 3900: 3899: 3897:Dihydroorotase 3894: 3892:Beta-lactamase 3889: 3883: 3881: 3870: 3869: 3867: 3866: 3865: 3864: 3854: 3849: 3844: 3839: 3838: 3837: 3832: 3829:Aspartoacylase 3826: 3816: 3811: 3806: 3801: 3795: 3793: 3782: 3781: 3769: 3768: 3761: 3754: 3746: 3737: 3736: 3734: 3733: 3727: 3720: 3718: 3712: 3705: 3702: 3699: 3698: 3693: 3692: 3685: 3678: 3670: 3651: 3650: 3638: 3637:External links 3635: 3633: 3632: 3579: 3526: 3475: 3440: 3397: 3354: 3311: 3258: 3223: 3180: 3137: 3099:(9): 4868–73. 3084: 3049: 3014: 2986:(6628): 16–7. 2971: 2928: 2899: 2860: 2816: 2814: 2811: 2809: 2808: 2767: 2718: 2697:(8): 1318–28. 2677: 2634: 2582: 2530: 2481: 2432: 2383: 2321: 2280: 2216: 2181:Molecular Cell 2165: 2124: 2075: 2025: 1996:(9): 2215–25. 1976: 1932: 1883: 1863: 1822: 1808: 1767: 1728:(9): 4868–73. 1705: 1687: 1669: 1648: 1626: 1624: 1621: 1620: 1619: 1612: 1609: 1607: 1606: 1600: 1594: 1588: 1582: 1576: 1570: 1564: 1558: 1552: 1546: 1540: 1534: 1528: 1522: 1515: 1506: 1503: 1495:photoreceptors 1486: 1483: 1444: 1441: 1417: 1416: 1413: 1412: 1407: 1397: 1396: 1390: 1389: 1386: 1385: 1383: 1381: 1374: 1373: 1366: 1359: 1355: 1354: 1351: 1350: 1340: 1339: 1333: 1330: 1329: 1303: 1302: 1296: 1292: 1291: 1288: 1287: 1277: 1276: 1270: 1267: 1266: 1240: 1239: 1233: 1229: 1228: 1225: 1224: 1216: 1215: 1209: 1206: 1205: 1197: 1196: 1190: 1184: 1183: 1180: 1179: 1171: 1170: 1164: 1161: 1160: 1152: 1151: 1145: 1139: 1138: 1135: 1134: 1126: 1125: 1119: 1116: 1115: 1107: 1106: 1100: 1094: 1093: 1088: 1083: 1079: 1078: 1068: 1067: 1064: 1063: 1052: 1051: 1049: 1048: 1043: 1038: 1033: 1028: 1023: 1018: 1013: 1008: 1003: 998: 993: 988: 983: 978: 973: 968: 963: 958: 953: 948: 943: 938: 933: 928: 923: 918: 913: 908: 903: 898: 893: 888: 883: 878: 873: 868: 863: 858: 853: 848: 843: 838: 833: 828: 823: 817: 815: 811: 810: 808: 807: 802: 797: 792: 787: 782: 777: 772: 767: 762: 757: 752: 746: 744: 740: 739: 737: 736: 731: 726: 721: 716: 711: 706: 701: 696: 691: 686: 681: 676: 671: 666: 661: 656: 651: 646: 640: 638: 634: 633: 623: 622: 619: 618: 615: 614: 606: 605: 594: 588: 587: 584: 583: 575: 574: 571: 570: 568: 567: 563: 559: 555: 551: 547: 543: 539: 535: 531: 527: 524: 523: 512: 509: 508: 506: 505: 501: 497: 496:deltoid muscle 493: 489: 485: 481: 477: 473: 469: 465: 462: 461: 449: 448: 440: 429: 423: 422: 419:RNA expression 411: 410: 407: 406: 398: 394: 393: 385: 382: 377: 371: 370: 361: 354: 348: 344: 343: 338: 332: 331: 323: 322: 310: 309: 306: 305: 297: 293: 292: 284: 281: 276: 270: 269: 260: 253: 247: 243: 242: 235: 229: 228: 220: 219: 207: 206: 163: 159: 158: 150: 142: 141: 137: 136: 133: 132: 129: 128: 66: 65: 57: 56: 45: 39: 38: 30: 29: 21: 20: 9: 6: 4: 3: 2: 4393: 4382: 4379: 4377: 4374: 4373: 4371: 4361: 4356: 4351: 4350: 4347: 4333: 4329: 4328: 4323: 4320: 4316: 4315: 4310: 4307: 4303: 4302: 4297: 4294: 4290: 4289: 4284: 4281: 4277: 4276: 4271: 4268: 4264: 4263: 4258: 4255: 4251: 4250: 4245: 4244: 4242: 4238: 4232: 4229: 4227: 4224: 4222: 4219: 4217: 4214: 4212: 4209: 4208: 4206: 4202: 4196: 4193: 4191: 4190:Enzyme family 4188: 4186: 4183: 4181: 4178: 4177: 4175: 4171: 4165: 4162: 4160: 4157: 4155: 4154:Cooperativity 4152: 4150: 4147: 4146: 4144: 4140: 4134: 4131: 4129: 4126: 4124: 4121: 4119: 4116: 4114: 4113:Oxyanion hole 4111: 4109: 4106: 4104: 4101: 4099: 4096: 4095: 4093: 4089: 4085: 4078: 4073: 4071: 4066: 4064: 4059: 4058: 4055: 4043: 4042:Thiaminase II 4040: 4038: 4037:Riboflavinase 4035: 4034: 4032: 4029: 4025: 4019: 4016: 4015: 4013: 4011: 4006: 4002: 3994: 3991: 3989: 3986: 3985: 3984: 3981: 3979: 3976: 3974: 3971: 3969: 3966: 3964: 3963:AMP deaminase 3961: 3959: 3956: 3954: 3951: 3950: 3948: 3946: 3941: 3937: 3931: 3928: 3926: 3923: 3921: 3918: 3917: 3915: 3913: 3908: 3904: 3898: 3895: 3893: 3890: 3888: 3885: 3884: 3882: 3880: 3875: 3871: 3863: 3860: 3859: 3858: 3855: 3853: 3850: 3848: 3845: 3843: 3840: 3836: 3833: 3830: 3827: 3825: 3822: 3821: 3820: 3817: 3815: 3812: 3810: 3807: 3805: 3802: 3800: 3797: 3796: 3794: 3792: 3787: 3783: 3778: 3774: 3767: 3762: 3760: 3755: 3753: 3748: 3747: 3744: 3730: 3724: 3719: 3715: 3709: 3704: 3703: 3700: 3691: 3686: 3684: 3679: 3677: 3672: 3671: 3668: 3664: 3663: 3661: 3660:public domain 3657: 3648: 3644: 3641: 3640: 3629: 3625: 3620: 3615: 3610: 3605: 3601: 3597: 3593: 3589: 3585: 3580: 3576: 3572: 3567: 3562: 3557: 3552: 3548: 3544: 3540: 3536: 3532: 3527: 3523: 3519: 3514: 3509: 3505: 3501: 3497: 3493: 3489: 3485: 3481: 3476: 3472: 3468: 3463: 3458: 3454: 3450: 3446: 3441: 3437: 3433: 3428: 3423: 3419: 3415: 3411: 3407: 3403: 3398: 3394: 3390: 3385: 3380: 3376: 3372: 3368: 3364: 3360: 3355: 3351: 3347: 3342: 3337: 3333: 3329: 3325: 3321: 3317: 3312: 3308: 3304: 3299: 3294: 3289: 3284: 3280: 3276: 3272: 3268: 3264: 3259: 3255: 3251: 3246: 3241: 3237: 3233: 3229: 3224: 3220: 3216: 3211: 3206: 3202: 3198: 3194: 3190: 3186: 3181: 3177: 3173: 3168: 3163: 3159: 3155: 3151: 3147: 3143: 3138: 3134: 3130: 3125: 3120: 3115: 3110: 3106: 3102: 3098: 3094: 3090: 3085: 3081: 3077: 3072: 3067: 3063: 3059: 3055: 3050: 3046: 3042: 3037: 3032: 3028: 3024: 3020: 3015: 3011: 3007: 3003: 2999: 2994: 2989: 2985: 2981: 2977: 2972: 2968: 2964: 2959: 2954: 2950: 2946: 2942: 2938: 2934: 2929: 2925: 2921: 2917: 2913: 2910:(1): 107–13. 2909: 2905: 2900: 2896: 2892: 2887: 2882: 2878: 2874: 2871:(5): 286–93. 2870: 2866: 2861: 2857: 2853: 2849: 2845: 2840: 2835: 2831: 2827: 2823: 2818: 2817: 2804: 2800: 2795: 2790: 2786: 2782: 2778: 2771: 2763: 2759: 2754: 2749: 2745: 2741: 2737: 2733: 2729: 2722: 2714: 2710: 2705: 2700: 2696: 2692: 2688: 2681: 2673: 2669: 2665: 2661: 2657: 2653: 2650:(1–2): 1–12. 2649: 2645: 2638: 2630: 2626: 2621: 2616: 2612: 2608: 2604: 2600: 2596: 2589: 2587: 2578: 2574: 2570: 2566: 2561: 2556: 2552: 2548: 2541: 2534: 2526: 2522: 2517: 2512: 2508: 2504: 2500: 2496: 2492: 2485: 2477: 2473: 2468: 2463: 2459: 2455: 2451: 2447: 2443: 2436: 2428: 2424: 2419: 2414: 2410: 2406: 2402: 2398: 2394: 2387: 2379: 2375: 2370: 2365: 2360: 2355: 2351: 2347: 2343: 2339: 2335: 2328: 2326: 2317: 2313: 2308: 2303: 2299: 2295: 2291: 2284: 2276: 2272: 2267: 2262: 2257: 2252: 2248: 2244: 2240: 2236: 2232: 2225: 2223: 2221: 2212: 2208: 2203: 2198: 2194: 2190: 2186: 2182: 2174: 2172: 2170: 2161: 2157: 2152: 2147: 2143: 2139: 2135: 2128: 2120: 2116: 2111: 2106: 2102: 2098: 2094: 2090: 2086: 2079: 2071: 2067: 2063: 2059: 2055: 2051: 2047: 2043: 2036: 2029: 2021: 2017: 2013: 2009: 2004: 1999: 1995: 1991: 1990:FASEB Journal 1987: 1980: 1972: 1968: 1963: 1958: 1954: 1950: 1946: 1939: 1937: 1928: 1924: 1919: 1914: 1910: 1906: 1902: 1898: 1894: 1887: 1880: 1876: 1872: 1867: 1859: 1855: 1850: 1845: 1841: 1837: 1833: 1826: 1818: 1812: 1804: 1800: 1795: 1790: 1786: 1782: 1778: 1771: 1763: 1759: 1754: 1749: 1744: 1739: 1735: 1731: 1727: 1723: 1719: 1712: 1710: 1701: 1697: 1691: 1683: 1679: 1673: 1666: 1662: 1657: 1655: 1653: 1645: 1641: 1636: 1634: 1632: 1627: 1618: 1615: 1614: 1604: 1601: 1598: 1595: 1592: 1589: 1586: 1583: 1580: 1577: 1574: 1571: 1568: 1565: 1562: 1559: 1556: 1553: 1550: 1547: 1544: 1541: 1538: 1535: 1532: 1529: 1526: 1523: 1520: 1517: 1516: 1514: 1512: 1502: 1500: 1496: 1492: 1482: 1480: 1476: 1473: 1469: 1465: 1461: 1457: 1453: 1449: 1440: 1438: 1435: 1431: 1427: 1423: 1411: 1406: 1402: 1398: 1395: 1391: 1384: 1382: 1379: 1375: 1371: 1367: 1364: 1360: 1356: 1349: 1347: 1341: 1337: 1334: 1328: 1326: 1322: 1318: 1314: 1310: 1304: 1300: 1297: 1293: 1286: 1284: 1278: 1274: 1271: 1265: 1263: 1259: 1255: 1251: 1247: 1241: 1237: 1234: 1232:RefSeq (mRNA) 1230: 1223: 1222: 1217: 1213: 1210: 1204: 1203: 1198: 1194: 1191: 1189: 1185: 1178: 1177: 1172: 1168: 1165: 1159: 1158: 1153: 1149: 1146: 1144: 1140: 1133: 1132: 1127: 1123: 1120: 1114: 1113: 1108: 1104: 1101: 1099: 1095: 1092: 1089: 1087: 1084: 1080: 1077: 1073: 1069: 1062: 1058: 1053: 1047: 1044: 1042: 1039: 1037: 1034: 1032: 1029: 1027: 1024: 1022: 1019: 1017: 1014: 1012: 1009: 1007: 1004: 1002: 999: 997: 994: 992: 989: 987: 984: 982: 979: 977: 974: 972: 969: 967: 964: 962: 959: 957: 954: 952: 949: 947: 944: 942: 939: 937: 934: 932: 929: 927: 924: 922: 919: 917: 914: 912: 909: 907: 904: 902: 899: 897: 894: 892: 889: 887: 884: 882: 879: 877: 874: 872: 869: 867: 864: 862: 859: 857: 854: 852: 849: 847: 844: 842: 839: 837: 834: 832: 829: 827: 824: 822: 819: 818: 816: 813: 812: 806: 803: 801: 798: 796: 793: 791: 788: 786: 783: 781: 778: 776: 773: 771: 768: 766: 763: 761: 758: 756: 753: 751: 748: 747: 745: 742: 741: 735: 732: 730: 727: 725: 722: 720: 717: 715: 712: 710: 707: 705: 702: 700: 697: 695: 692: 690: 687: 685: 682: 680: 677: 675: 672: 670: 667: 665: 662: 660: 657: 655: 652: 650: 647: 645: 642: 641: 639: 636: 635: 632: 631:Gene ontology 628: 624: 612: 607: 603: 598: 595: 593: 589: 581: 576: 565: 562:muscle tissue 561: 557: 553: 549: 545: 541: 537: 533: 529: 528: 525: 521: 516: 513: 503: 499: 495: 491: 487: 483: 479: 475: 471: 467: 466: 463: 459: 454: 451: 450: 447: 445: 441: 439: 438: 434: 433: 430: 428: 424: 420: 416: 412: 404: 399: 395: 391: 386: 376: 372: 365: 358: 352: 345: 337: 333: 329: 324: 320: 315: 311: 303: 298: 294: 290: 285: 275: 271: 264: 257: 251: 244: 240: 234: 230: 226: 221: 217: 212: 208: 204: 200: 196: 192: 188: 184: 180: 176: 172: 168: 160: 155: 148: 143: 138: 127: 125: 121: 117: 113: 109: 105: 101: 97: 93: 89: 85: 81: 77: 73: 67: 62: 59: 58: 54: 51: 44: 40: 35: 31: 27: 22: 17: 4327:Translocases 4324: 4311: 4298: 4285: 4272: 4262:Transferases 4259: 4246: 4103:Binding site 3819:Aminoacylase 3799:Asparaginase 3728: 3713: 3653: 3652: 3591: 3587: 3538: 3534: 3487: 3483: 3452: 3448: 3409: 3405: 3366: 3362: 3323: 3319: 3270: 3266: 3235: 3231: 3192: 3188: 3149: 3145: 3096: 3092: 3061: 3057: 3026: 3023:DNA Research 3022: 2983: 2979: 2943:(4): 353–8. 2940: 2936: 2907: 2903: 2868: 2864: 2832:(3): 325–8. 2829: 2825: 2784: 2780: 2770: 2735: 2731: 2721: 2694: 2690: 2680: 2647: 2643: 2637: 2605:(1): 45–54. 2602: 2598: 2550: 2546: 2533: 2498: 2494: 2484: 2449: 2445: 2435: 2400: 2396: 2386: 2341: 2337: 2297: 2293: 2283: 2238: 2234: 2187:(1): 45–57. 2184: 2180: 2141: 2137: 2127: 2092: 2088: 2078: 2045: 2041: 2028: 1993: 1989: 1979: 1952: 1948: 1900: 1896: 1886: 1878: 1870: 1866: 1839: 1835: 1825: 1811: 1784: 1780: 1770: 1725: 1721: 1699: 1690: 1681: 1672: 1508: 1505:Interactions 1488: 1446: 1433: 1425: 1421: 1420: 1343: 1325:NP_001365346 1321:NP_001365345 1317:NP_001365344 1313:NP_001365343 1306: 1280: 1262:NM_001378417 1258:NM_001378416 1254:NM_001378415 1250:NM_001378414 1243: 1219: 1200: 1174: 1155: 1129: 1110: 1090: 1085: 530:otic vesicle 442: 435: 300:239,401,654 287:239,048,168 162:External IDs 69: 4098:Active site 4007:: Nitriles/ 3887:Barbiturase 3814:Biotinidase 3804:Glutaminase 3696:PDB gallery 3455:(1): 35–9. 3029:(1): 53–9. 1460:acetylation 800:nucleoplasm 654:DNA binding 534:granulocyte 468:sural nerve 401:92,123,421 388:91,856,501 140:Identifiers 4370:Categories 4301:Isomerases 4275:Hydrolases 4142:Regulation 3925:Agmatinase 3842:Ceramidase 3773:Hydrolases 2886:2268/80861 1667:, May 2017 1646:, May 2017 1623:References 1464:chromosome 1456:cell cycle 785:actomyosin 775:Z discdkac 446:(ortholog) 380:1|1 D 183:HomoloGene 4180:EC number 4018:Nitrilase 1501:of mice. 1346:NP_997108 1309:NP_006028 1283:NM_207225 1246:NM_006037 1076:Orthologs 770:sarcomere 750:cytoplasm 191:GeneCards 4381:EC 3.5.1 4204:Kinetics 4128:Cofactor 4091:Activity 3920:Arginase 3628:11114197 3575:11114188 3522:11081517 3471:11022042 3436:10958686 3393:10944117 3350:10898795 3307:10869435 3254:10825153 3219:10523670 3176:10487761 3133:10220385 3080:10206986 3010:29803420 2895:12711221 2856:11488594 2803:15467736 2781:Oncogene 2762:11504882 2713:11463856 2672:19487189 2664:12943985 2629:10640275 2577:39220205 2569:10748098 2525:10487761 2476:11486037 2427:10523670 2378:11114188 2316:11466315 2275:10869435 2211:11804585 2160:14668799 2138:Oncogene 2119:12242305 2062:27333946 2012:17371797 1971:11929873 1927:19131628 1858:17610967 1803:10206986 1762:10220385 1663:– 1642:– 1611:See also 1511:interact 1448:Histones 1443:Function 1394:Wikidata 1055:Sources: 538:gastrula 4360:Biology 4314:Ligases 4084:Enzymes 4030:: Other 3862:Sirtuin 3596:Bibcode 3543:Bibcode 3513:4459600 3492:Bibcode 3275:Bibcode 3167:1171580 3101:Bibcode 3045:9179496 3002:9139815 2967:9110174 2924:8619474 2848:9150131 2516:1171580 2346:Bibcode 2243:Bibcode 2070:4070837 2020:4974360 1918:3339762 1897:Science 1730:Bibcode 1665:Ensembl 1644:Ensembl 1499:retinas 1430:protein 1428:, is a 1188:UniProt 1143:Ensembl 1082:Species 1061:QuickGO 795:cytosol 790:nucleus 421:pattern 179:3036234 147:Aliases 4346:Portal 4288:Lyases 4028:3.5.99 3831:(ACY2) 3809:Urease 3649:(MeSH) 3626:  3616:  3573:  3563:  3520:  3510:  3484:Nature 3469:  3434:  3424:  3391:  3384:302030 3381:  3348:  3341:316791 3338:  3305:  3295:  3252:  3217:  3207:  3174:  3164:  3131:  3121:  3078:  3043:  3008:  3000:  2980:Nature 2965:  2958:139146 2955:  2922:  2893:  2854:  2846:  2801:  2760:  2750:  2711:  2670:  2662:  2627:  2620:316335 2617:  2575:  2567:  2523:  2513:  2474:  2464:  2425:  2415:  2376:  2366:  2314:  2273:  2263:  2209:  2158:  2117:  2110:139799 2107:  2068:  2060:  2018:  2010:  1969:  1925:  1915:  1856:  1801:  1760:  1750:  1513:with: 1380:search 1378:PubMed 1221:Q6NZM9 1202:P56524 1131:208727 1098:Entrez 780:A band 592:BioGPS 472:glutes 279:2q37.3 171:605314 4240:Types 4005:3.5.5 3988:AICDA 3940:3.5.4 3907:3.5.3 3874:3.5.2 3786:3.5.1 3619:18930 3566:18918 3427:88766 3298:16631 3210:84849 3124:21783 3006:S2CID 2852:S2CID 2753:55849 2668:S2CID 2573:S2CID 2543:(PDF) 2467:87317 2418:84849 2369:18918 2266:16631 2066:S2CID 2038:(PDF) 2016:S2CID 1753:21783 1599:, and 1597:YWHAE 1591:YWHAB 1561:MEF2C 1555:MAPK3 1549:MAPK1 1543:HDAC3 1537:GATA1 1479:MEF2D 1475:MEF2C 1434:HDAC4 1426:HDAC4 1091:Mouse 1086:Human 1057:Amigo 504:blood 444:Mouse 437:Human 384:Start 319:Mouse 283:Start 216:Human 195:HDAC4 187:55946 154:HDAC4 19:HDAC4 4332:list 4325:EC7 4319:list 4312:EC6 4306:list 4299:EC5 4293:list 4286:EC4 4280:list 4273:EC3 4267:list 4260:EC2 4254:list 4247:EC1 3835:ACY3 3824:ACY1 3779:3.5) 3729:2o94 3714:2h8n 3624:PMID 3571:PMID 3518:PMID 3467:PMID 3432:PMID 3389:PMID 3346:PMID 3303:PMID 3250:PMID 3215:PMID 3172:PMID 3129:PMID 3076:PMID 3041:PMID 2998:PMID 2963:PMID 2920:PMID 2891:PMID 2844:PMID 2826:Cell 2799:PMID 2758:PMID 2709:PMID 2660:PMID 2625:PMID 2565:PMID 2521:PMID 2472:PMID 2423:PMID 2374:PMID 2312:PMID 2271:PMID 2207:PMID 2156:PMID 2115:PMID 2058:PMID 2008:PMID 1967:PMID 1923:PMID 1854:PMID 1840:1773 1799:PMID 1758:PMID 1531:CBX5 1525:BTG2 1519:BCL6 1477:and 1437:gene 1112:9759 427:Bgee 375:Band 336:Chr. 274:Band 233:Chr. 167:OMIM 124:5A2S 120:4CBY 116:4CBT 112:3V31 108:3UZD 104:3UXG 100:2VQW 96:2VQV 92:2VQQ 88:2VQO 84:2VQM 80:2VQJ 76:2O94 72:2H8N 53:RCSB 50:PDBe 3614:PMC 3604:doi 3561:PMC 3551:doi 3508:PMC 3500:doi 3488:408 3457:doi 3453:276 3422:PMC 3414:doi 3379:PMC 3371:doi 3336:PMC 3328:doi 3293:PMC 3283:doi 3240:doi 3236:275 3205:PMC 3197:doi 3162:PMC 3154:doi 3119:PMC 3109:doi 3066:doi 3062:274 3031:doi 2988:doi 2984:387 2953:PMC 2945:doi 2912:doi 2908:236 2881:hdl 2873:doi 2834:doi 2789:doi 2748:PMC 2740:doi 2699:doi 2652:doi 2648:206 2615:PMC 2607:doi 2555:doi 2551:275 2511:PMC 2503:doi 2462:PMC 2454:doi 2413:PMC 2405:doi 2364:PMC 2354:doi 2302:doi 2298:276 2261:PMC 2251:doi 2197:hdl 2189:doi 2146:doi 2105:PMC 2097:doi 2050:doi 2046:232 1998:doi 1957:doi 1953:277 1913:PMC 1905:doi 1901:323 1879:300 1844:doi 1789:doi 1785:274 1748:PMC 1738:doi 554:lip 397:End 296:End 199:OMA 175:MGI 43:PDB 4372:: 3777:EC 3622:. 3612:. 3602:. 3592:97 3590:. 3586:. 3569:. 3559:. 3549:. 3539:97 3537:. 3533:. 3516:. 3506:. 3498:. 3486:. 3482:. 3465:. 3451:. 3447:. 3430:. 3420:. 3410:20 3408:. 3404:. 3387:. 3377:. 3367:19 3365:. 3361:. 3344:. 3334:. 3324:14 3322:. 3318:. 3301:. 3291:. 3281:. 3271:97 3269:. 3265:. 3248:. 3234:. 3230:. 3213:. 3203:. 3193:19 3191:. 3187:. 3170:. 3160:. 3150:18 3148:. 3144:. 3127:. 3117:. 3107:. 3097:96 3095:. 3091:. 3074:. 3060:. 3056:. 3039:. 3025:. 3021:. 3004:. 2996:. 2982:. 2978:. 2961:. 2951:. 2939:. 2935:. 2918:. 2906:. 2889:. 2879:. 2869:19 2867:. 2850:. 2842:. 2830:89 2828:. 2824:. 2797:. 2785:23 2783:. 2779:. 2756:. 2746:. 2736:29 2734:. 2730:. 2707:. 2695:15 2693:. 2689:. 2666:. 2658:. 2646:. 2623:. 2613:. 2603:14 2601:. 2597:. 2585:^ 2571:. 2563:. 2549:. 2545:. 2519:. 2509:. 2499:18 2497:. 2493:. 2470:. 2460:. 2450:21 2448:. 2444:. 2421:. 2411:. 2401:19 2399:. 2395:. 2372:. 2362:. 2352:. 2342:97 2340:. 2336:. 2324:^ 2310:. 2296:. 2292:. 2269:. 2259:. 2249:. 2239:97 2237:. 2233:. 2219:^ 2205:. 2195:. 2183:. 2168:^ 2154:. 2142:22 2140:. 2136:. 2113:. 2103:. 2093:22 2091:. 2087:. 2064:. 2056:. 2044:. 2040:. 2014:. 2006:. 1994:21 1992:. 1988:. 1965:. 1951:. 1947:. 1935:^ 1921:. 1911:. 1899:. 1895:. 1877:, 1873:, 1852:. 1838:. 1834:. 1797:. 1783:. 1779:. 1756:. 1746:. 1736:. 1726:96 1724:. 1720:. 1708:^ 1698:. 1680:. 1651:^ 1630:^ 1454:, 1439:. 1059:/ 403:bp 390:bp 302:bp 289:bp 197:; 193:: 189:; 185:: 181:; 177:: 173:; 169:: 122:, 118:, 114:, 110:, 106:, 102:, 98:, 94:, 90:, 86:, 82:, 78:, 74:, 4348:: 4334:) 4330:( 4321:) 4317:( 4308:) 4304:( 4295:) 4291:( 4282:) 4278:( 4269:) 4265:( 4256:) 4252:( 4076:e 4069:t 4062:v 3765:e 3758:t 3751:v 3689:e 3682:t 3675:v 3662:. 3630:. 3606:: 3598:: 3577:. 3553:: 3545:: 3524:. 3502:: 3494:: 3473:. 3459:: 3438:. 3416:: 3395:. 3373:: 3352:. 3330:: 3309:. 3285:: 3277:: 3256:. 3242:: 3221:. 3199:: 3178:. 3156:: 3135:. 3111:: 3103:: 3082:. 3068:: 3047:. 3033:: 3027:4 3012:. 2990:: 2969:. 2947:: 2941:7 2926:. 2914:: 2897:. 2883:: 2875:: 2858:. 2836:: 2805:. 2791:: 2764:. 2742:: 2715:. 2701:: 2674:. 2654:: 2631:. 2609:: 2579:. 2557:: 2527:. 2505:: 2478:. 2456:: 2429:. 2407:: 2380:. 2356:: 2348:: 2318:. 2304:: 2277:. 2253:: 2245:: 2213:. 2199:: 2191:: 2185:9 2162:. 2148:: 2121:. 2099:: 2072:. 2052:: 2022:. 2000:: 1973:. 1959:: 1929:. 1907:: 1860:. 1846:: 1819:. 1805:. 1791:: 1764:. 1740:: 1732:: 1702:. 1684:. 1605:. 1593:, 1587:, 1581:, 1575:, 1569:, 1563:, 1557:, 1551:, 1545:, 1539:, 1533:, 1527:, 1521:, 321:) 218:) 201::

Index


PDB
PDBe
RCSB
2H8N
2O94
2VQJ
2VQM
2VQO
2VQQ
2VQV
2VQW
3UXG
3UZD
3V31
4CBT
4CBY
5A2S
Aliases
HDAC4
OMIM
605314
MGI
3036234
HomoloGene
55946
GeneCards
HDAC4
OMA
HDAC4 - orthologs

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